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https://www.readbyqxmd.com/read/27904163/the-impact-of-direct-cardiac-output-determination-on-using-a-widely-available-direct-continuous-oxygen-consumption-measuring-device-on-the-hemodynamic-assessment-of-aortic-valve
#1
Zaher Fanari, Matthew Grove, Anitha Rajamanickam, Sumaya Hammami, Cassie Walls, Paul Kolm, Mitchell Saltzberg, William S Weintraub, Andrew J Doorey
BACKGROUND: Accurate assessment of cardiac output (CO) is essential for the hemodynamic assessment of aortic valve area (AVA). Estimation of oxygen consumption (VO2) and Thermodilution (TD) is employed in many cardiac catheterization laboratories (CCL) given the historically cumbersome nature of direct continuous VO2 measurement, the "gold standard" for this technique. A portable facemask device simplifies the direct continuous measurement of VO2, allowing for relatively rapid and continuous assessment of CO and AVA...
September 2016: Delaware Medical Journal
https://www.readbyqxmd.com/read/27888672/incidence-of-coronary-intervention-in-cardiac-arrest-survivors-with-non-shockable-initial-rhythms-and-no-evidence-of-st-elevation-mi-stemi
#2
Matthew Wilson, Anne V Grossestreuer, David F Gaieski, Benjamin S Abella, William Frohna, Munish Goyal
OBJECTIVE: With the demonstrated benefit of an early-invasive strategy for STEMI and VF/VT arrest patients, there is interest in assessing the potential benefit of early angiography for non-shockable (PEA/Asystole) arrest patients. We hypothesized that in cardiac arrest patients who obtain return of spontaneous circulation (ROSC) after a non-shockable initial rhythm and do not have STEMI the incidence of coronary intervention would be clinically insignificant (<5%). METHODS: Retrospective multicenter US clinical registry study of post-cardiac arrest patients at 18 hospitals between 1/00 and 5/14...
November 23, 2016: Resuscitation
https://www.readbyqxmd.com/read/27836871/patient-safety-events-in-out-of-hospital-paediatric-airway-management-a-medical-record-review-by-the-csi-ems
#3
Matthew Hansen, Garth Meckler, William Lambert, Caitlin Dickinson, Kathryn Dickinson, Joshua Van Otterloo, Jeanne-Marie Guise
OBJECTIVE: To describe the frequency and characterise the nature of patient safety events in paediatric out-of-hospital airway management. METHODS: We conducted a retrospective cross-sectional medical record review of all 'lights and sirens' emergency medicine services transports from 2008 to 2011 in patients <18 years of age in the Portland Oregon metropolitan area. A chart review tool (see online supplementary appendix) was adapted from landmark patient safety studies and revised after pilot testing...
November 11, 2016: BMJ Open
https://www.readbyqxmd.com/read/27659885/the-effect-of-high-risk-st-elevation-myocardial-infarction-transfer-patients-on-risk-adjusted-in-hospital-mortality-a-report-from-the-american-heart-association-mission-lifeline-program
#4
Michael C Kontos, Tracy Y Wang, Anita Y Chen, Eric R Bates, Harold L Dauerman, Timothy D Henry, Steven V Manoukian, Matthew T Roe, Robert Suter, Laine Thomas, William J French
BACKGROUND: Hospital mortality is an important quality measure for acute myocardial infarction care. There is a concern that despite risk adjustment, percutaneous coronary intervention hospitals accepting a greater volume of high-risk ST elevation myocardial infarction (STEMI) transfer patients may have their reported mortality rates adversely affected. METHODS: The STEMI patients in the National Cardiovascular Data RegistryAcute Coronary Treatment Intervention Outcomes Network Registry-Get With the Guidelines from April 2011 to December 2013 were included...
October 2016: American Heart Journal
https://www.readbyqxmd.com/read/27645989/a-novel-method-for-epicardial-defibrillator-lead-placement-in-young-children-coil-between-the-great-arteries
#5
Raghav Murthy, Matthew R Williams, James C Perry, Suzanne Shepard, Daniel DiBardino
The primary and secondary prevention of sudden cardiac death resulting from malignant arrhythmia, channelopathy, and hypertrophic cardiomyopathy often requires the implantation of automatic internal cardiac defibrillators (AICDs) in the pediatric population. In young patients, the small size of the systemic veins, complex anatomy of congenital heart disease, and body habitus often preclude safe and durable transvenous placement of the AICD coil, requiring innovative methods to circumvent this problem. This report describes the technique used at Rady Children's Hospital San Diego/UCSD for the epicardial placement of an ICD system with a transvenous ICD coil placed between the aorta and pulmonary artery, thereby producing a stable location and excellent coil-to-can vector for successful defibrillation...
October 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27644061/pausing-with-the-gauze-inhibition-of-temporary-pacemakers-by-radiofrequency-scan-during-cardiac-surgery
#6
Matthew R Williams, Douglas B Atkinson, Vassilios J Bezzerides, Yuki Koichi, Kathryn Franklin, Alfonso Casta, Mark E Alexander
BACKGROUND: Radiofrequency identification (RFID) detection systems are used to detect retained surgical sponges and may cause electromagnetic interference (EMI), altering intended function of cardiac pacing systems. Three pediatric patients requiring temporary pacing for postoperative atrioventricular block experienced transient inhibition of ventricular pacing during the use of RFID detection system. Bench testing was performed to evaluate the mechanism of pacemaker inhibition. METHODS: Impedance of temporary pacing wires was obtained using a pacing system analyzer...
September 16, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27579776/bi-layered-polyurethane-extracellular-matrix-cardiac-patch-improves-ischemic-ventricular-wall-remodeling-in-a-rat-model
#7
Antonio D'Amore, Tomo Yoshizumi, Samuel K Luketich, Matthew T Wolf, Xinzhu Gu, Marcello Cammarata, Richard Hoff, Stephen F Badylak, William R Wagner
As an intervention to abrogate ischemic cardiomyopathy, the concept of applying a temporary, local patch to the surface of the recently infarcted ventricle has been explored from a number of design perspectives. Two important features considered for such a cardiac patch include the provision of appropriate mechanical support and the capacity to influence the remodeling pathway by providing cellular or biomolecule delivery. The objective of this report was to focus on these two features by first evaluating the incorporation of a cardiac extracellular matrix (ECM) component, and second by evaluating the impact of patch anisotropy on the pathological remodeling process initiated by myocardial infarction...
November 2016: Biomaterials
https://www.readbyqxmd.com/read/27516706/robust-spatio-temporal-registration-of-4d-cardiac-ultrasound-sequences
#8
Jørn Bersvendsen, Matthew Toews, Adriyana Danudibroto, William M Wells, Stig Urheim, Raúl San José Estépar, Eigil Samset
Registration of multiple 3D ultrasound sectors in order to provide an extended field of view is important for the appreciation of larger anatomical structures at high spatial and temporal resolution. In this paper, we present a method for fully automatic spatio-temporal registration between two partially overlapping 3D ultrasound sequences. The temporal alignment is solved by aligning the normalized cross correlation-over-time curves of the sequences. For the spatial alignment, corresponding 3D Scale Invariant Feature Transform (SIFT) features are extracted from all frames of both sequences independently of the temporal alignment...
February 27, 2016: Proceedings of SPIE
https://www.readbyqxmd.com/read/27515327/coronary-physiology-during-exercise-and-vasodilation-in-the-healthy-heart-and-in-severe-aortic-stenosis
#9
Matthew Lumley, Rupert Williams, Kaleab N Asrress, Satpal Arri, Natalia Briceno, Howard Ellis, Ronak Rajani, Maria Siebes, Jan J Piek, Brian Clapp, Simon R Redwood, Michael S Marber, John B Chambers, Divaka Perera
BACKGROUND: Severe aortic stenosis (AS) can manifest as exertional angina even in the presence of unobstructed coronary arteries. OBJECTIVES: The authors describe coronary physiological changes during exercise and hyperemia in the healthy heart and in patients with severe AS. METHODS: Simultaneous intracoronary pressure and flow velocity recordings were made in unobstructed coronary arteries of 22 patients with severe AS (mean effective orifice area 0...
August 16, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27479907/distinct-genetic-architectures-for-syndromic-and-nonsyndromic-congenital-heart-defects-identified-by-exome-sequencing
#10
Alejandro Sifrim, Marc-Phillip Hitz, Anna Wilsdon, Jeroen Breckpot, Saeed H Al Turki, Bernard Thienpont, Jeremy McRae, Tomas W Fitzgerald, Tarjinder Singh, Ganesh Jawahar Swaminathan, Elena Prigmore, Diana Rajan, Hashim Abdul-Khaliq, Siddharth Banka, Ulrike M M Bauer, Jamie Bentham, Felix Berger, Shoumo Bhattacharya, Frances Bu'Lock, Natalie Canham, Irina-Gabriela Colgiu, Catherine Cosgrove, Helen Cox, Ingo Daehnert, Allan Daly, John Danesh, Alan Fryer, Marc Gewillig, Emma Hobson, Kirstin Hoff, Tessa Homfray, Anne-Karin Kahlert, Ami Ketley, Hans-Heiner Kramer, Katherine Lachlan, Anne Katrin Lampe, Jacoba J Louw, Ashok Kumar Manickara, Dorin Manase, Karen P McCarthy, Kay Metcalfe, Carmel Moore, Ruth Newbury-Ecob, Seham Osman Omer, Willem H Ouwehand, Soo-Mi Park, Michael J Parker, Thomas Pickardt, Martin O Pollard, Leema Robert, David J Roberts, Jennifer Sambrook, Kerry Setchfield, Brigitte Stiller, Chris Thornborough, Okan Toka, Hugh Watkins, Denise Williams, Michael Wright, Seema Mital, Piers E F Daubeney, Bernard Keavney, Judith Goodship, Riyadh Mahdi Abu-Sulaiman, Sabine Klaassen, Caroline F Wright, Helen V Firth, Jeffrey C Barrett, Koenraad Devriendt, David R FitzPatrick, J David Brook, Matthew E Hurles
Congenital heart defects (CHDs) have a neonatal incidence of 0.8-1% (refs. 1,2). Despite abundant examples of monogenic CHD in humans and mice, CHD has a low absolute sibling recurrence risk (∼2.7%), suggesting a considerable role for de novo mutations (DNMs) and/or incomplete penetrance. De novo protein-truncating variants (PTVs) have been shown to be enriched among the 10% of 'syndromic' patients with extra-cardiac manifestations. We exome sequenced 1,891 probands, including both syndromic CHD (S-CHD, n = 610) and nonsyndromic CHD (NS-CHD, n = 1,281)...
September 2016: Nature Genetics
https://www.readbyqxmd.com/read/27471206/high-attenuation-areas-on-chest-computed-tomography-in-community-dwelling-adults-the-mesa-study
#11
Anna J Podolanczuk, Elizabeth C Oelsner, R Graham Barr, Eric A Hoffman, Hilary F Armstrong, John H M Austin, Robert C Basner, Matthew N Bartels, Jason D Christie, Paul L Enright, Bernadette R Gochuico, Karen Hinckley Stukovsky, Joel D Kaufman, P Hrudaya Nath, John D Newell, Scott M Palmer, Dan Rabinowitz, Ganesh Raghu, Jessica L Sell, Jered Sieren, Sushil K Sonavane, Russell P Tracy, Jubal R Watts, Kayleen Williams, Steven M Kawut, David J Lederer
Evidence suggests that lung injury, inflammation and extracellular matrix remodelling precede lung fibrosis in interstitial lung disease (ILD). We examined whether a quantitative measure of increased lung attenuation on computed tomography (CT) detects lung injury, inflammation and extracellular matrix remodelling in community-dwelling adults sampled without regard to respiratory symptoms or smoking.We measured high attenuation areas (HAA; percentage of lung voxels between -600 and -250 Hounsfield Units) on cardiac CT scans of adults enrolled in the Multi-Ethnic Study of Atherosclerosis...
November 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27437887/intracoronary-gene-transfer-of-adenylyl-cyclase-6-in-patients-with-heart-failure-a-randomized-clinical-trial
#12
H Kirk Hammond, William F Penny, Jay H Traverse, Timothy D Henry, Matthew W Watkins, Clyde W Yancy, Ranya N Sweis, Eric D Adler, Amit N Patel, David R Murray, Robert S Ross, Valmik Bhargava, Alan Maisel, Denise D Barnard, N Chin Lai, Nancy D Dalton, Martin L Lee, Sanjiv M Narayan, Daniel G Blanchard, Mei Hua Gao
IMPORTANCE: Gene transfer has rarely been tested in randomized clinical trials. OBJECTIVE: To evaluate the safety and efficacy of intracoronary delivery of adenovirus 5 encoding adenylyl cyclase 6 (Ad5.hAC6) in heart failure. DESIGN, SETTING, AND PARTICIPANTS: A randomized, double-blind, placebo-controlled, phase 2 clinical trial was conducted in US medical centers (randomization occurred from July 19, 2010, to October 30, 2014). Participants 18 to 80 years with symptomatic heart failure (ischemic and nonischemic) and an ejection fraction (EF) of 40% or less were screened; 86 individuals were enrolled, and 56 were randomized...
May 1, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27387839/the-validity-of-discharge-billing-codes-reflecting-severe-maternal-morbidity
#13
Matthew J G Sigakis, Lisa R Leffert, Hooman Mirzakhani, Nadir Sharawi, Baskar Rajala, William M Callaghan, Elena V Kuklina, Andreea A Creanga, Jill M Mhyre, Brian T Bateman
BACKGROUND: Discharge diagnoses are used to track national trends and patterns of maternal morbidity. There are few data regarding the validity of the International Classification of Diseases (ICD) codes used for this purpose. The goal of our study was to try to better understand the validity of administrative data being used to monitor and assess trends in morbidity. METHODS: Hospital stay billing records were queried to identify all delivery admissions at the Massachusetts General Hospital for the time period 2001 to 2011 and the University of Michigan Health System for the time period 2005 to 2011...
September 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27364051/ectopic-and-visceral-fat-deposition-in%C3%A2-lean-and-obese-patients-with-type%C3%A2-2%C3%A2-diabetes
#14
Eylem Levelt, Michael Pavlides, Rajarshi Banerjee, Masliza Mahmod, Catherine Kelly, Joanna Sellwood, Rina Ariga, Sheena Thomas, Jane Francis, Christopher Rodgers, William Clarke, Nikant Sabharwal, Charalambos Antoniades, Jurgen Schneider, Matthew Robson, Kieran Clarke, Theodoros Karamitsos, Oliver Rider, Stefan Neubauer
BACKGROUND: Type 2 diabetes (T2D) and obesity are associated with nonalcoholic fatty liver disease, cardiomyopathy, and cardiovascular mortality. Both show stronger links between ectopic and visceral fat deposition, and an increased cardiometabolic risk compared with subcutaneous fat. OBJECTIVES: This study investigated whether lean patients (Ln) with T2D exhibit increased ectopic and visceral fat deposition and whether these are linked to cardiac and hepatic changes...
July 5, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27326664/dilated-cardiomyopathy-phosphorus-31-mr-spectroscopy-at-7-t
#15
Victoria M Stoll, William T Clarke, Eylem Levelt, Alexander Liu, Saul G Myerson, Matthew D Robson, Stefan Neubauer, Christopher T Rodgers
Purpose To test whether the increased signal-to-noise ratio of phosphorus 31 ((31)P) magnetic resonance (MR) spectroscopy at 7 T improves precision in cardiac metabolite quantification in patients with dilated cardiomyopathy (DCM) compared with that at 3 T. Materials and Methods Ethical approval was obtained, and participants provided written informe consent. In a prospective study, (31)P MR spectroscopy was performed at 3 T and 7 T in 25 patients with DCM. Ten healthy matched control subjects underwent (31)P MR spectroscopy at 7 T...
June 20, 2016: Radiology
https://www.readbyqxmd.com/read/27207130/lower-extremity-complications-with-femoral-extracorporeal-life-support
#16
Prashanth Vallabhajosyula, Matthew Kramer, Sofiane Lazar, Fenton McCarthy, Eduardo Rame, Joyce Wald, Wilson Szeto, Matthew Williams, Pavan Atluri, Nimesh Desai, Michael Acker
OBJECTIVE: Patients undergoing emergency peripheral arteriovenous extracorporeal life support were evaluated for lower-extremity complications on the basis of the ipsilateral limb perfusion strategy. METHODS: In a retrospective review of patients receiving extracorporeal life support (2008-2013), 105 of 250 underwent femoral extracorporeal life support. For ipsilateral lower-extremity perfusion, patients underwent no superficial femoral artery cannulation (n = 35), percutaneous superficial femoral artery cannulation (n = 23), or open superficial femoral artery cannulation (n = 47)...
June 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27184505/functional-assessment-of-bioprosthetic-aortic%C3%A2-valves-by-cmr
#17
Dimitrios Maragiannis, Matthew S Jackson, Jose H Flores-Arredondo, Kyle Autry, Robert C Schutt, Paulino A Alvarez, William A Zoghbi, Dipan J Shah, Stephen H Little
OBJECTIVES: The aim of this study was to evaluate cardiac magnetic resonance (CMR) phase-contrast (PC) measures of a bioprosthetic aortic valve velocity time integral (PC-VTI) to derive the effective orifice area (PC-EOA) and to compare these findings with the clinical standard of Doppler echocardiography. BACKGROUND: Bioprosthetic aortic valve function can be assessed with CMR planimetry of the anatomic orifice area and PC measurement of peak transvalvular systolic velocity...
July 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27076226/right-atrial-emptying-fraction-non-invasively-predicts-mortality-in-pulmonary-hypertension
#18
Konstadina Darsaklis, Matthew E Dickson, William Cornwell, Colby R Ayers, Fernando Torres, Kelly M Chin, Susan Matulevicius
Right-sided heart failure is the most common cause of death in pulmonary hypertension (PH). Echocardiographic measurements of right atrial (RA) size are associated with worse outcome in PH, however the association between RA function and death in PH has not been well-described. 160 PH patients (World Health Organization groups 1-5) underwent cardiac magnetic resonance imaging (cMRI) and right heart catheterization (RHC) within 6 weeks of each other at a tertiary care academic medical center in the United States...
July 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27053648/peripheral-venous-distension-elicits-a-blood-pressure-raising-reflex-in-young-and-middle-aged-adults
#19
Evan L Matthews, Michael S Brian, Dana E Coyle, David G Edwards, Sean D Stocker, Megan M Wenner, William B Farquhar
Distension of peripheral veins in humans elicits a pressor and sympathoexcitatory response that is mediated through group III/IV skeletal muscle afferents. There is some evidence that autonomic reflexes mediated by these sensory fibers are blunted with increasing age, yet to date the venous distension reflex has only been studied in young adults. Therefore, we tested the hypothesis that the venous distension reflex would be attenuated in middle-aged compared with young adults. Nineteen young (14 men/5 women, 25 ± 1 yr) and 13 middle-aged (9 men/4 women, 50 ± 2 yr) healthy normotensive participants underwent venous distension via saline infusion through a retrograde intravenous catheter in an antecubital vein during limb occlusion...
June 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27048764/burden-of-systolic-and-diastolic-left-ventricular-dysfunction-among-hispanics-in-the-united-states-insights-from-the-echocardiographic-study-of-latinos
#20
MULTICENTER STUDY
Hardik Mehta, Anderson Armstrong, Katrina Swett, Sanjiv J Shah, Matthew A Allison, Barry Hurwitz, Shrikant Bangdiwala, Rupal Dadhania, Dalane W Kitzman, William Arguelles, Joao Lima, Marston Youngblood, Neil Schneiderman, Martha L Daviglus, Daniel Spevack, Greg A Talavera, Ajit Raisinghani, Robert Kaplan, Carlos J Rodriguez
BACKGROUND: Population-based estimates of cardiac dysfunction and clinical heart failure (HF) remain undefined among Hispanics/Latino adults. METHODS AND RESULTS: Participants of Hispanic/Latino origin across the United States aged 45 to 74 years were enrolled into the Echocardiographic Study of Latinos (ECHO-SOL) and underwent a comprehensive echocardiography examination to define left ventricular systolic dysfunction (LVSD) and left ventricular diastolic dysfunction (LVDD)...
April 2016: Circulation. Heart Failure
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