Claudia H T Tam, Cadmon K P Lim, Andrea O Y Luk, Mai Shi, Hoi Man Cheung, Alex C W Ng, Heung-Man Lee, Eric S H Lau, Baoqi Fan, Guozhi Jiang, Alice P S Kong, Risa Ozaki, Elaine Y K Chow, Ka Fai Lee, Shing Chung Siu, Grace Hui, Chiu Chi Tsang, Kam Piu Lau, Jenny Y Y Leung, Elaine Y N Cheung, Man Wo Tsang, Grace Kam, Ip Tim Lau, June K Y Li, Vincent T F Yeung, Emmy Lau, Stanley Lo, Samuel Fung, Yuk Lun Cheng, Chun Chung Chow, Xiaodan Fan, Ting Fung Chan, Kevin Y L Yip, Si Lok, Weichuan Yu, Stephen K W Tsui, Hui-Yao Lan, Cheuk Chun Szeto, Nelson L S Tang, Brian Tomlinson, Yu Huang, Alicia J Jenkins, Anthony Keech, Wing-Yee So, Juliana C N Chan, Ronald C W Ma
OBJECTIVE: In this study we aim to unravel genetic determinants of coronary heart disease (CHD) in type 2 diabetes (T2D) and explore their applications. RESEARCH DESIGN AND METHODS: We performed a two-stage genome-wide association study for CHD in Chinese patients with T2D (3,596 case and 8,898 control subjects), followed by replications in European patients with T2D (764 case and 4,276 control subjects) and general populations (n = 51,442-547,261). Each identified variant was examined for its association with a wide range of phenotypes and its interactions with glycemic, blood pressure (BP), and lipid controls in incident cardiovascular diseases...
June 1, 2023: Diabetes Care