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W Szeto

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https://www.readbyqxmd.com/read/28415980/the-effects-of-bending-speed-on-the-lumbo-pelvic-kinematics-and-movement-pattern-during-forward-bending-in-people-with-and-without-low-back-pain
#1
Sharon M H Tsang, Grace P Y Szeto, Linda M K Li, Dim C M Wong, Millie M P Yip, Raymond Y W Lee
BACKGROUND: Impaired lumbo-pelvic movement in people with low back pain during bending task has been reported previously. However, the regional mobility and the pattern of the lumbo-pelvic movement were found to vary across studies. The inconsistency of the findings may partly be related to variations in the speed at which the task was executed. This study examined the effects of bending speeds on the kinematics and the coordination lumbo-pelvic movement during forward bending, and to compare the performance of individuals with and without low back pain...
April 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28407211/long-term-alterations-in-monocyte-function-after-elective-cardiac-surgery
#2
M Zawadka, J Wahome, H Oszkiel, W Y Szeto, B Cobb, K Laudanski
Optimal immunological homoeostasis determines the long-term recovery of patients in the postoperative period. The functional adaptability of monocytes plays a pivotal role in adjusting the host's response to an insult, immunostasis and long-term health, and may help to determine successful recovery. We undertook a longitudinal analysis of the functional adaptability of monocytes in 20 patients undergoing heart surgery with cardiopulmonary bypass, as a model of severe stress. Using each patient's pre-cardiopulmonary bypass data as a baseline, we investigated the characteristics of peripheral blood monocytes' functional plasticity in-vitro before elective bypass, and three months afterwards...
April 13, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28360365/ispd-catheter-related-infection-recommendations-2017-update
#3
Cheuk-Chun Szeto, Philip Kam-Tao Li, David W Johnson, Judith Bernardini, Jie Dong, Ana E Figueiredo, Yasuhiko Ito, Rumeyza Kazancioglu, Thyago Moraes, Sadie Van Esch, Edwina A Brown
No abstract text is available yet for this article.
March 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28261724/a-new-approach-for-the-preparation-of-well-defined-rh-and-pt-nanoparticles-stabilized-by-phosphine-functionalized-silica-for-selective-hydrogenation-reactions
#4
J Llop Castelbou, K C Szeto, W Barakat, N Merle, C Godard, M Taoufik, C Claver
In this work, a new methodology for the synthesis of well-defined metallic nanoparticles supported on silica is described. This methodology is based on the surface control provided by SOMC. The nanoparticles are formed via the organometallic approach and are catalytically active in the hydrogenation of p-xylene, 3-hexyne, 4-phenyl-2 butanone, benzaldehyde, and furfural.
March 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28238813/genomewide-bisulfite-sequencing-reveals-the-origin-and-time-dependent-fragmentation-of-urinary-cfdna
#5
Timothy H T Cheng, Peiyong Jiang, Jacqueline C W Tam, Xiao Sun, Wing-Shan Lee, Stephanie C Y Yu, Jeremy Y C Teoh, Peter K F Chiu, Chi-Fai Ng, Kai-Ming Chow, Cheuk-Chun Szeto, K C Allen Chan, Rossa W K Chiu, Y M Dennis Lo
Urinary cell-free (cf) DNA holds great potential as a completely noninvasive form of liquid biopsy. Knowledge of the composition of cfDNA by tissue of origin is useful for guiding its clinical uses. We conducted a global survey of urinary cfDNA composition using genomewide bisulfite sequencing. While previous studies focused on detecting cfDNA from a single source at a time, genomewide tissue specific methylation signatures allow us to simultaneously deduce the proportional contribution from each contributing tissue...
February 23, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28153193/low-gdp-solution-and-glucose-sparing-strategies-for-peritoneal-dialysis
#6
REVIEW
Cheuk Chun Szeto, David W Johnson
Long-term exposure to a high glucose concentration in conventional peritoneal dialysis (PD) solution has a number of direct and indirect (via glucose degradation products [GDP]) detrimental effects on the peritoneal membrane, as well as systemic metabolism. Glucose- or GDP-sparing strategies often are hypothesized to confer clinical benefits to PD patients. Icodextrin (glucose polymer) solution improves peritoneal ultrafiltration and reduces the risk of fluid overload, but these beneficial effects are probably the result of better fluid removal rather than being glucose sparing...
January 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28102082/characterization-of-the-molecular-mechanisms-underlying-the-chronic-phase-of-stroke-in-a-cynomolgus-monkey-model-of-induced-cerebral-ischemia
#7
Henry C H Law, Samuel S W Szeto, Quan Quan, Yun Zhao, Zaijun Zhang, Olga Krakovska, Leong Ting Lui, Chengyou Zheng, Simon M-Y Lee, K W Michael Siu, Yuqiang Wang, Ivan K Chu
Stroke is one of the main causes of mortality and long-term disability worldwide. The pathophysiological mechanisms underlying this disease are not well understood, particularly in the chronic phase after the initial ischemic episode. In this study, a Macaca fascicularis stroke model consisting of two sample groups, as determined by MRI-quantified infarct volumes as a measure of the stroke severity 28 days after the ischemic episode, was evaluated using qualitative and quantitative proteomics analyses. By using multiple online multidimensional liquid chromatography platforms, 8790 nonredundant proteins were identified that condensed to 5223 protein groups at 1% global false discovery rate (FDR)...
February 2, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28063595/the-mitochondrial-targeted-peptide-ss-31-improves-glomerular-architecture-in-mice-of-advanced-age
#8
Mariya T Sweetwyne, Jeffrey W Pippin, Diana G Eng, Kelly L Hudkins, Ying Ann Chiao, Matthew D Campbell, David J Marcinek, Charles E Alpers, Hazel H Szeto, Peter S Rabinovitch, Stuart J Shankland
Although age-associated changes in kidney glomerular architecture have been described in mice and man, the mechanisms are unknown. It is unclear if these changes can be prevented or even reversed by systemic therapies administered at advanced age. Using light microscopy and transmission electron microscopy, our results showed glomerulosclerosis with injury to mitochondria in glomerular epithelial cells in mice aged 26 months (equivalent to a 79-year-old human). To test the hypothesis that reducing mitochondrial damage in late age would result in lowered glomerulosclerosis, we administered the mitochondrial targeted peptide, SS-31, to aged mice...
May 2017: Kidney International
https://www.readbyqxmd.com/read/27926855/temporally-programmed-cd8%C3%AE-dc-activation-enhances-combination-cancer-immunotherapy
#9
Alice Tzeng, Monique J Kauke, Eric F Zhu, Kelly D Moynihan, Cary F Opel, Nicole J Yang, Naveen Mehta, Ryan L Kelly, Gregory L Szeto, Willem W Overwijk, Darrell J Irvine, K Dane Wittrup
Numerous synergistic cancer immunotherapy combinations have been identified, but the effects of relative dose timing are rarely considered. In established syngeneic mouse tumor models, we found that staggering interferon-α (IFNα) administration after, rather than before or simultaneously with, serum-persistent interleukin-2 (IL-2) and tumor-specific antibody significantly increased long-term survival. Successful combination therapy required IFNα-induced activation of cross-presenting CD8α(+) dendritic cells (DCs) following the release of antigenic tumor debris by the IL-2- and antibody-mediated immune response...
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27675469/effect-of-titanium-hardware-on-radiation-dosimetry-in-postoperative-proton-versus-photon-spinal-stereotactic-body-radiation-therapy-after-surgical-decompression-for-spinal-cord-compression
#10
V H Lee, T W Lam, S C Ng, M H Szeto, K O Lam, T W Leung
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27667448/extraction-and-analysis-of-signatures-from-the-gene-expression-omnibus-by-the-crowd
#11
Zichen Wang, Caroline D Monteiro, Kathleen M Jagodnik, Nicolas F Fernandez, Gregory W Gundersen, Andrew D Rouillard, Sherry L Jenkins, Axel S Feldmann, Kevin S Hu, Michael G McDermott, Qiaonan Duan, Neil R Clark, Matthew R Jones, Yan Kou, Troy Goff, Holly Woodland, Fabio M R Amaral, Gregory L Szeto, Oliver Fuchs, Sophia M Schüssler-Fiorenza Rose, Shvetank Sharma, Uwe Schwartz, Xabier Bengoetxea Bausela, Maciej Szymkiewicz, Vasileios Maroulis, Anton Salykin, Carolina M Barra, Candice D Kruth, Nicholas J Bongio, Vaibhav Mathur, Radmila D Todoric, Udi E Rubin, Apostolos Malatras, Carl T Fulp, John A Galindo, Ruta Motiejunaite, Christoph Jüschke, Philip C Dishuck, Katharina Lahl, Mohieddin Jafari, Sara Aibar, Apostolos Zaravinos, Linda H Steenhuizen, Lindsey R Allison, Pablo Gamallo, Fernando de Andres Segura, Tyler Dae Devlin, Vicente Pérez-García, Avi Ma'ayan
Gene expression data are accumulating exponentially in public repositories. Reanalysis and integration of themed collections from these studies may provide new insights, but requires further human curation. Here we report a crowdsourcing project to annotate and reanalyse a large number of gene expression profiles from Gene Expression Omnibus (GEO). Through a massive open online course on Coursera, over 70 participants from over 25 countries identify and annotate 2,460 single-gene perturbation signatures, 839 disease versus normal signatures, and 906 drug perturbation signatures...
September 26, 2016: Nature Communications
https://www.readbyqxmd.com/read/27616218/solvent-free-ring-opening-metathesis-polymerization-of-norbornene-over-silica-supported-tungsten-oxo-perhydrocarbyl-catalysts
#12
Cherif Larabi, Kai C Szeto, Yassine Bouhoute, Marc O Charlin, Nicolas Merle, Aimery De Mallmann, Regis M Gauvin, Laurent Delevoye, Mostafa Taoufik
Ring opening metathesis polymerization (ROMP) of bicyclo[2.2.1]hept-2-ene (norbornene) is carried out over silica-supported catalysts based on tungsten complexes bearing an oxo ligand (1: [(SiO)W(O)(CH2 SiMe3 )3 , 2: [(SiO)W(O)(CHCMe2 Ph)(dAdPO)], dAdPO  2,6 diadamantyl-4-methylphenoxide, 3: [(SiO)2 W(O)(CH2 SiMe3 )2 ]). The evaluation of the catalytic activities of the aforementioned materials in ROMP indicates that at low reaction time (0.5 min), the highest polymer yield is obtained with catalyst 2...
September 12, 2016: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/27544289/valve-selection-in-end-stage-renal-disease-should-it-always-be-biological
#13
COMPARATIVE STUDY
Matthew L Williams, Joseph E Bavaria, Michael A Acker, Nimesh D Desai, Prashanth Vallabhajosyula, W Clark Hargrove, Pavan Atluri, Wilson Y Szeto
BACKGROUND: When valve replacement is required in patients with end-stage renal disease (ESRD), it is not clear if mechanical or bioprosthetic valve selection is better. We compared outcomes between ESRD patients who underwent either mechanical or biologic valve replacements at our institution. METHODS: All patients with ESRD who underwent either mitral or aortic valve replacement from 2002 to 2014 at our institution were reviewed (n = 215; mechanical = 64, biological = 151)...
November 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27542900/surgical-aortic-valve-replacement-clinical-update-on-recent-advances-in-the-contemporary-era
#14
REVIEW
Harish Ramakrishna, Prakash A Patel, Jacob T Gutsche, Prashanth Vallabhajosyula, Wilson Y Szeto, Emily MacKay, Jared W Feinman, Ronak Shah, Elizabeth Zhou, Stuart J Weiss, John G Augoustides
No abstract text is available yet for this article.
December 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27340778/desmoglein-2-promotes-vasculogenic-mimicry-in-melanoma-and-is-associated-with-poor-clinical-outcome
#15
Lih Yin Tan, Chris Mintoff, M Zahied Johan, Brenton W Ebert, Clare Fedele, You Fang Zhang, Pacman Szeto, Karen E Sheppard, Grant A McArthur, Erwin Foster-Smith, Andrew Ruszkiewicz, Michael P Brown, Claudine S Bonder, Mark Shackleton, Lisa M Ebert
Tumors can develop a blood supply not only by promoting angiogenesis but also by forming vessel-like structures directly from tumor cells, known as vasculogenic mimicry (VM). Understanding mechanisms that regulate VM is important, as these might be exploitable to inhibit tumor progression. Here, we reveal the adhesion molecule desmoglein 2 (DSG2) as a novel mediator of VM in melanoma. Analysis of patient-derived melanoma cell lines and tumor tissues, and interrogation of The Cancer Genome Atlas (TCGA) data, revealed that DSG2 is frequently overexpressed in primary and metastatic melanomas compared to normal melanocytes...
July 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27338829/a-non-canonical-role-for-desmoglein-2-in-endothelial-cells-implications-for-neoangiogenesis
#16
Lisa M Ebert, Lih Y Tan, M Zahied Johan, Kay Khine Myo Min, Michaelia P Cockshell, Kate A Parham, Kelly L Betterman, Paceman Szeto, Samantha Boyle, Lokugan Silva, Angela Peng, YouFang Zhang, Andrew Ruszkiewicz, Andrew C W Zannettino, Stan Gronthos, Simon Koblar, Natasha L Harvey, Angel F Lopez, Mark Shackleton, Claudine S Bonder
Desmogleins (DSG) are a family of cadherin adhesion proteins that were first identified in desmosomes and provide cardiomyocytes and epithelial cells with the junctional stability to tolerate mechanical stress. However, one member of this family, DSG2, is emerging as a protein with additional biological functions on a broader range of cells. Here we reveal that DSG2 is expressed by non-desmosome-forming human endothelial progenitor cells as well as their mature counterparts [endothelial cells (ECs)] in human tissue from healthy individuals and cancer patients...
October 2016: Angiogenesis
https://www.readbyqxmd.com/read/27325642/cd271-expression-on-patient-melanoma-cells-is-unstable-and-unlinked-to-tumorigenicity
#17
Samantha E Boyle, Clare G Fedele, Vincent Corbin, Elisha Wybacz, Pacman Szeto, Jeremy Lewin, Richard J Young, Annie Wong, Robert Fuller, John Spillane, David Speakman, Simon Donahoe, Miklos Pohl, David Gyorki, Michael A Henderson, Ricky W Johnstone, Anthony T Papenfuss, Mark Shackleton
The stability of markers that identify cancer cells that propagate disease is important to the outcomes of targeted therapy strategies. In human melanoma, conflicting data exist as to whether hierarchical expression of CD271/p75/NGFR (nerve growth factor receptor) marks cells with enriched tumorigenicity, which would compel their specific targeting in therapy. To test whether these discrepancies relate to differences among groups in assay approaches, we undertook side-by-side testing of published methods of patient-derived melanoma xenografting (PDX), including comparisons of tissue digestion procedures or coinjected Matrigel formulations...
July 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/27318775/the-impact-of-deep-versus-moderate-hypothermia-on-postoperative-kidney-function-after-elective-aortic-hemiarch-repair
#18
COMPARATIVE STUDY
George J Arnaoutakis, Prashanth Vallabhajosyula, Joseph E Bavaria, Ibrahim Sultan, Mary Siki, Suveeksha Naidu, Rita K Milewski, Matthew L Williams, W Clark Hargrove, Nimesh D Desai, Wilson Y Szeto
BACKGROUND: There remains concern that moderate hypothermic circulatory arrest (MHCA) with antegrade cerebral perfusion (ACP) may provide suboptimal distal organ protection compared with deep hypothermic circulatory arrest (DHCA) with retrograde cerebral perfusion (RCP). We compared postoperative acute kidney injury (AKI) in in patients who underwent elective hemiarch repair with either DHCA/RCP or MHCA/ACP. METHODS: This was a retrospective review of all patients undergoing elective aortic hemiarch reconstruction for aneurysmal disease between 2009 and 2014...
October 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27297459/recombinant-biologic-products-versus-nutraceuticals-from-plants-a-regulatory-choice
#19
REVIEW
Pascal M W Drake, Tim H Szeto, Mathew J Paul, Audrey Y-H Teh, Julian K-C Ma
Biotechnology has transformed the potential for plants to be a manufacturing source of pharmaceutical compounds. Now, with transgenic and transient expression techniques, virtually any biologic, including vaccines and therapeutics, could be manufactured in plants. However, uncertainty over the regulatory path for such new pharmaceuticals has been a deterrent. Consideration has been given to using alternative regulatory paths, including those for nutraceuticals or cosmetic agents. This review will consider these possibilities, and discuss the difficulties in establishing regulatory guidelines for new pharmaceutical manufacturing technologies...
January 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27282851/ispd-peritonitis-recommendations-2016-update-on-prevention-and-treatment
#20
Philip Kam-Tao Li, Cheuk Chun Szeto, Beth Piraino, Javier de Arteaga, Stanley Fan, Ana E Figueiredo, Douglas N Fish, Eric Goffin, Yong-Lim Kim, William Salzer, Dirk G Struijk, Isaac Teitelbaum, David W Johnson
No abstract text is available yet for this article.
September 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
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