SJ Weiss

Systemic therapy of adrenocortical carcinoma (ACC) is limited by heterogeneous tumor response and adverse effects. Recently, we demonstrated anti-tumor activity of LEDP-M (etoposide, liposomal doxorubicin, liposomal cisplatin, mitotane), a liposomal variant of EDP-M (etoposide, doxorubicin, cisplatin, mitotane). To improve the therapeutic efficacy and off-target profiles of the clinical gold standard EDP-M, we investigated liposomal EDP-M regimens in different preclinical settings and in a small number of ACC patients with very advanced disease...

This investigation was designed to determine if relatively small manipulations of squat load and the inclusion of selected morphologic variables might augment the explained variance in vertical jump (VJ) displacement. Fifty-two university students (27 women and 25 men) with weight training experience served as subjects. All were assessed for body fat percentage (BF%), height, body weight (BW), leg length (LL), ankle range of motion, and quadriceps angle (Q-angle). Additionally, subjects performed drop vertical jumps (DVJs) and both countermovement jump (CMJ) squats and static jump (SJ) squats at 20, 30, and 40% of their back squat 1 repetition maximum (1RM)...

Although it is accepted that extracellular fields generated by neuronal activity can influence the excitability of neighboring cells, whether this form of neurotransmission has a functional role remains open. In vivo field effects occur in the teleost Mauthner (M)-cell system, where a combination of structural features support the concept of inhibitory electrical synapses. A single spike in one M-cell evoked within as little as 2.2 ms of the onset of an abrupt sound, simulating a predatory strike, initiates a startle-escape behavior [Zottoli SJ (1977) J Exp Biol 66:243-254]...

The crystal structures of [MnTPP]{Ni[S2C2H(CN)]2} [MnTPP = (meso-tetraphenylporphinato)manganese(III)] and [MnTPP]{Ni[S2C2(CN)2]2} have been determined. These salts possess trans-mu-coordination of S = 1/2 {Ni[S2C2H(CN)]2}*- and {Ni[S(2)C(2)(CN)(2)](2)}*- to Mn(III) and form parallel 1-D coordination polymer chains exhibiting nu(CN) at 2210 and 2200 and 2220 and 2212 cm(-1), respectively. The bis(dithiolato) monoanions are planar and bridge two cations with MnN distances of 2.339(16), and 2.394(3) A, respectively, which are comparable to related MnN distances observed for [MnTPP][TCNE]...

Activated phagocytes (especially polymorphonuclear granulocytes (PMNs)) by respiratory oxidative/photonic burst (activation of NADPH-oxidase and myeloper-oxidase) generate large amounts of oxidants of the hypochlorite-/chloramine-type, which are physiologic sources for singlet oxygen (1O2), a nonradical-excited (photon (h nu) emitting) oxygen species [Weiss SJ, NEJM 1989;320:365-376]. In vitro experiments show that 1O2 (1) inhibits coagulation by inactivation of thrombocytes, fibrinogen, factor V, factor VIII, and factor X and (2) activates fibrinolysis by inactivation of the main fibrinolysis inhibitors plasminogen activator inhibitor (PAI)-1 and alpha-2-antiplasmin, and by activation of single-chain urokinase by plasmin and oxidized fibrin...