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JOURNAL ARTICLE
Nathaniel R Smilowitz, Matthew C Weiss, Rina Mauricio, Asha M Mahajan, Kaitlyn E Dugan, Arvind Devanabanda, Claudia Pulgarin, Eugenia Gianos, Binita Shah, Steven P Sedlis, Martha Radford, Harmony R Reynolds
BACKGROUND: Type 2 myocardial infarction (MI) is defined as myocardial necrosis (myonecrosis) due to an imbalance in supply and demand with clinical evidence of ischemia. Some clinical scenarios of supply-demand mismatch predispose to myonecrosis but limit the identification of symptoms and ECG changes referable to ischemia; therefore, the MI definition may not be met. Factors that predispose to type 2 MI and myonecrosis without definite MI, approaches to treatment, and outcomes remain poorly characterized...
September 1, 2016: International Journal of Cardiology
#22
JOURNAL ARTICLE
Faiz Gani, Yuhree Kim, Matthew J Weiss, Martin A Makary, Christopher L Wolfgang, Kenzo Hirose, John L Cameron, Jack O Wasey, Steven M Frank, Timothy M Pawlik
BACKGROUND: Little is known regarding the effects of caseload volume of other relevant members of the "surgical team." The present study sought to report variations in health care utilization and outcomes relative to surgeon and anesthesiologist volume among patients undergoing pancreatic surgery. METHODS: A total of 969 patients undergoing pancreatic surgery from 2011-2013 were identified at a large, tertiary care center. Multivariable regression analyses explored the effects of provider volume on crystalloid administration, blood transfusions, mortality, length of stay, and hospital charges...
February 2016: Journal of Surgical Research
#23
JOURNAL ARTICLE
Hongjuan Liu, Steven G Wise, Jelena Rnjak-Kovacina, David L Kaplan, Marcela M M Bilek, Anthony S Weiss, Jian Fei, Shisan Bao
Blended polymers are used extensively in many critical medical conditions as components of permanently implanted devices. Hybrid protein polymers containing recombinant human tropoelastin and silk fibroin have favorable characteristics as implantable scaffolds in terms of mechanical and biological properties. A firefly luciferase transgenic mouse model was used to monitor real-time IL-1β production localized to the site of biomaterial implantation, to observe the acute immune response (up to 5 days) to these materials...
June 2014: Biomaterials
#24
JOURNAL ARTICLE
Donald J Lucas, Katherine I Schexneider, Matthew Weiss, Christopher L Wolfgang, Steven M Frank, Kenzo Hirose, Nita Ahuja, Martin Makary, John L Cameron, Timothy M Pawlik
INTRODUCTION: Patient-specific factors impacting the need for possible perioperative blood transfusions have not been examined in patients undergoing hepatopancreatobiliary (HPB) procedures. We sought to define the overall utilization of blood transfusions for HPB surgery stratified by procedure type, as well as identify patient-level risk factors for transfusion. METHODS: Hepatic and pancreatic resections were selected from the 2005-2011 American College of Surgeons National Surgical Quality Improvement Program's public use files...
April 2014: Journal of Gastrointestinal Surgery
#25
JOURNAL ARTICLE
Noam Shussman, Maria R Brown, Michael C Johnson, Giovanna Da Silva, Steven D Wexner, Eric G Weiss
INTRODUCTION: Laparoscopic surgery is associated with well-known benefits, one of which is earlier return of bowel function. Since the laparoscopic approach to colon resections was introduced in the early 1990s, it has become the standard of care. Hand-assisted laparoscopic surgery (HALS) is a surgical approach in which dissection is facilitated by the surgeon's hand within the abdominal cavity during laparoscopy. The purpose of this study was to compare the incidence of postoperative ileus and the need for nasogastric tube (NGT) decompression in patients undergoing elective colon resections...
December 2013: Surgical Endoscopy
#26
JOURNAL ARTICLE
Sandra L de Montbrun, Patricia L Roberts, Ann C Lowry, Glenn T Ault, Marcus J Burnstein, Peter A Cataldo, Eric J Dozois, Gary D Dunn, James Fleshman, Gerald A Isenberg, Najjia N Mahmoud, Richard K Reznick, Lisa Satterthwaite, David Schoetz, Judith L Trudel, Eric G Weiss, Steven D Wexner, Helen MacRae
OBJECTIVE: To develop and evaluate an objective method of technical skills assessment for graduating subspecialists in colorectal (CR) surgery-the Colorectal Objective Structured Assessment of Technical Skill (COSATS). BACKGROUND: It may be reasonable for the public to assume that surgeons certified as competent have had their technical skills assessed. However, technical skill, despite being the hallmark of a surgeon, is not directly assessed at the time of certification by surgical boards...
December 2013: Annals of Surgery
#27
JOURNAL ARTICLE
Amy L Ladd, Arnold-Peter C Weiss, Joseph J Crisco, Elisabet Hagert, Jennifer Moriatis Wolf, Steven Z Glickel, Jeffrey Yao
Although there are many surgical options to treat thumb carpometacarpal (CMC) arthritis, a precise etiology for this common disorder remains obscure. To better understand the physiology of the thumb CMC joint and treat pathology, it is helpful to examine the biomechanics, hormonal influences, and available surgical treatment options, along with the evolutionary roots of the thumb; its form and function, its functional demands; and the role of supporting ligaments based on their location, stability, and ultrastructure...
2013: Instructional Course Lectures
#28
JOURNAL ARTICLE
Paul A Northcott, David J H Shih, John Peacock, Livia Garzia, A Sorana Morrissy, Thomas Zichner, Adrian M Stütz, Andrey Korshunov, Jüri Reimand, Steven E Schumacher, Rameen Beroukhim, David W Ellison, Christian R Marshall, Anath C Lionel, Stephen Mack, Adrian Dubuc, Yuan Yao, Vijay Ramaswamy, Betty Luu, Adi Rolider, Florence M G Cavalli, Xin Wang, Marc Remke, Xiaochong Wu, Readman Y B Chiu, Andy Chu, Eric Chuah, Richard D Corbett, Gemma R Hoad, Shaun D Jackman, Yisu Li, Allan Lo, Karen L Mungall, Ka Ming Nip, Jenny Q Qian, Anthony G J Raymond, Nina T Thiessen, Richard J Varhol, Inanc Birol, Richard A Moore, Andrew J Mungall, Robert Holt, Daisuke Kawauchi, Martine F Roussel, Marcel Kool, David T W Jones, Hendrick Witt, Africa Fernandez-L, Anna M Kenney, Robert J Wechsler-Reya, Peter Dirks, Tzvi Aviv, Wieslawa A Grajkowska, Marta Perek-Polnik, Christine C Haberler, Olivier Delattre, Stéphanie S Reynaud, François F Doz, Sarah S Pernet-Fattet, Byung-Kyu Cho, Seung-Ki Kim, Kyu-Chang Wang, Wolfram Scheurlen, Charles G Eberhart, Michelle Fèvre-Montange, Anne Jouvet, Ian F Pollack, Xing Fan, Karin M Muraszko, G Yancey Gillespie, Concezio Di Rocco, Luca Massimi, Erna M C Michiels, Nanne K Kloosterhof, Pim J French, Johan M Kros, James M Olson, Richard G Ellenbogen, Karel Zitterbart, Leos Kren, Reid C Thompson, Michael K Cooper, Boleslaw Lach, Roger E McLendon, Darell D Bigner, Adam Fontebasso, Steffen Albrecht, Nada Jabado, Janet C Lindsey, Simon Bailey, Nalin Gupta, William A Weiss, László Bognár, Almos Klekner, Timothy E Van Meter, Toshihiro Kumabe, Teiji Tominaga, Samer K Elbabaa, Jeffrey R Leonard, Joshua B Rubin, Linda M Liau, Erwin G Van Meir, Maryam Fouladi, Hideo Nakamura, Giuseppe Cinalli, Miklós Garami, Peter Hauser, Ali G Saad, Achille Iolascon, Shin Jung, Carlos G Carlotti, Rajeev Vibhakar, Young Shin Ra, Shenandoah Robinson, Massimo Zollo, Claudia C Faria, Jennifer A Chan, Michael L Levy, Poul H B Sorensen, Matthew Meyerson, Scott L Pomeroy, Yoon-Jae Cho, Gary D Bader, Uri Tabori, Cynthia E Hawkins, Eric Bouffet, Stephen W Scherer, James T Rutka, David Malkin, Steven C Clifford, Steven J M Jones, Jan O Korbel, Stefan M Pfister, Marco A Marra, Michael D Taylor
Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. As medulloblastoma exhibits marked intertumoural heterogeneity, with at least four distinct molecular variants, previous attempts to identify targets for therapy have been underpowered because of small samples sizes. Here we report somatic copy number aberrations (SCNAs) in 1,087 unique medulloblastomas. SCNAs are common in medulloblastoma, and are predominantly subgroup-enriched...
August 2, 2012: Nature
#29
COMPARATIVE STUDY
Art Hiranyakas, Assar Rather, Giovanna da Silva, Eric G Weiss, Steven D Wexner
BACKGROUND: Temporary loop ileostomy is commonly performed to protect the distal anastomosis during both open and laparoscopic colectomies. This study aimed to evaluate the impact of initial open and laparoscopic colorectal resection on the outcomes of ileostomy closure. METHODS: After institutional review board approval, all patients who underwent loop ileostomy closure from January 2008 to July 2012 were identified. The patients' demographics, diagnosis, American Society of Anesthesiology (ASA) classification, type of resection, approach (laparoscopic [LS] or open [OS] surgery), use of anti-adhesion barrier, and ileostomy closure outcomes were obtained from a chart review...
January 2013: Surgical Endoscopy
#30
JOURNAL ARTICLE
Sylvia Hsu, Kim Alexander Papp, Mark G Lebwohl, Jerry Bagel, Andrew Blauvelt, Kristina Callis Duffin, Jeffrey Crowley, Lawrence F Eichenfield, Steven R Feldman, David F Fiorentino, Joel M Gelfand, Alice B Gottlieb, Carmen Jacobsen, Robert E Kalb, Arthur Kavanaugh, Neil J Korman, Gerald G Krueger, Melissa A Michelon, Warwick Morison, Christopher T Ritchlin, Linda Stein Gold, Stephen P Stone, Bruce E Strober, Abby S Van Voorhees, Stefan C Weiss, Karolyn Wanat, Bruce F Bebo
The Canadian Guidelines for the Management of Plaque Psoriasis were reviewed by the entire National Psoriasis Foundation Medical Board and updated to include newly approved agents such as ustekinumab and to reflect practice patterns in the United States, where the excimer laser is approved for psoriasis treatment. Management of psoriasis in special populations is discussed. In the updated guidelines, we include sections on children, pregnant patients or pregnant partners of patients, nursing mothers, the elderly, patients with hepatitis B or C virus infections, human immunodeficiency virus-infected patients, and patients with malignant neoplasms, as well as sections on tumor necrosis factor blockers, elective surgery, and vaccinations...
January 2012: Archives of Dermatology
#31
COMPARATIVE STUDY
Rodrigo A Pinto, Dan Ruiz, Yair Edden, Eric G Weiss, Juan J Nogueras, Steven D Wexner
BACKGROUND: Due to the current increased longevity in the elderly population and the increased size of that population, major abdominal intervention is more frequently performed among octogenarians. This study aimed to compare the surgical and postoperative outcomes of laparoscopic colorectal resections with those of open surgery in the octogenarian population. METHODS: Retrospective analysis based on a prospectively maintained database of octogenarians who underwent laparoscopic or open elective colorectal resections from 2001 to 2008 was performed...
August 2011: Surgical Endoscopy
#32
REVIEW
C William Hanke, Rod J Rohrich, Mariano Busso, Alastair Carruthers, Jean Carruthers, Steven Fagien, Rebecca Fitzgerald, Richard Glogau, Phyllis E Greenberger, Z Paul Lorenc, Ellen S Marmur, Gary D Monheit, Andrea Pusic, Mark G Rubin, Berthold Rzany, Anthony Sclafani, Susan Taylor, Susan Weinkle, Michael F McGuire, David M Pariser, Laurie A Casas, Karen J Collishaw, Roger A Dailey, Stephen C Duffy, Elizabeth Jan Edgar, Barbara L Greenan, Kelly Haenlein, Ronald A Henrichs, Keith M Hume, Flora Lum, David R Nielsen, Lisle Poulsen, Lori Shoaf, William Seward, Wendy Smith Begolka, Robert G Stanton, Katherine J Svedman, J Regan Thomas, Jonathan M Sykes, Carol Wargo, Robert A Weiss
The American Academy of Dermatology and the American Society of Plastic Surgeons, with the support of other sister societies, conducted the Facial Soft-Tissue Fillers: Assessing the State of the Science conference in December of 2009. The American Academy of Dermatology and the American Society of Plastic Surgeons established a panel of leading experts in the field of soft-tissue fillers-from researchers to clinicians-and other stakeholders for the conference to examine and discuss issues of patient safety, efficacy, and effectiveness in relation to the approved and off-label use of soft-tissue fillers, and other factors, including the training and level of experience of individuals administering fillers...
April 2011: Journal of the American Academy of Dermatology
#33
JOURNAL ARTICLE
C William Hanke, Rod J Rohrich, Mariano Busso, Alastair Carruthers, Jean Carruthers, Steven Fagien, Rebecca Fitzgerald, Richard Glogau, Phyllis E Greenberger, Z Paul Lorenc, Ellen S Marmur, Gary D Monheit, Andrea Pusic, Mark G Rubin, Berthold Rzany, Anthony Sclafani, Susan Taylor, Susan Weinkle, Michael F McGuire, David M Pariser, Laurie A Casas, Karen J Collishaw, Roger A Dailey, Stephen C Duffy, Elizabeth Jan Edgar, Barbara L Greenan, Kelly Haenlein, Ronald A Henrichs, Keith M Hume, Flora Lum, David R Nielsen, Lisle Poulsen, Lori Shoaf, William Seward, Wendy Smith Begolka, Robert G Stanton, Katherine J Svedman, J Regan Thomas, Jonathan M Sykes, Carol Wargo, Robert A Weiss
The American Academy of Dermatology and the American Society of Plastic Surgeons, with the support of other sister societies, conducted the Facial Soft-Tissue Fillers: Assessing the State of the Science conference in December of 2009. The American Academy of Dermatology and the American Society of Plastic Surgeons established a panel of leading experts in the field of soft-tissue fillers-from researchers to clinicians-and other stakeholders for the conference to examine and discuss issues of patient safety, efficacy, and effectiveness in relation to the approved and off-label use of soft-tissue fillers, and other factors, including the training and level of experience of individuals administering fillers...
April 2011: Journal of the American Academy of Dermatology
#34
JOURNAL ARTICLE
Danielle E Weiss, Hannes Vogel, M Beatriz S Lopes, Steven D Chang, Laurence Katznelson
OBJECTIVE: To present a case of acromegaly due to ectopic growth hormone-releasing hormone (GHRH) secretion from a pancreatic neuroendocrine tumor in the context of multiple endocrine neoplasia type 1 (MEN 1). METHODS: We describe the clinical, imaging, and pathologic findings of the study patient. RESULTS: A 46-year-old woman presented with clinical and biochemical findings diagnostic of acromegaly. Magnetic resonance imaging showed a 1.2-cm sellar mass...
January 2011: Endocrine Practice
#35
JOURNAL ARTICLE
Steven G Wise, Michael J Byrom, Anna Waterhouse, Paul G Bannon, Anthony S Weiss, Martin K C Ng
Small-diameter synthetic vascular graft materials fail to match the patency of human tissue conduits used in vascular bypass surgery. The foreign surface retards endothelialization and is highly thrombogenic, while the mismatch in mechanical properties induces intimal hyperplasia. Using recombinant human tropoelastin, we have developed a synthetic vascular conduit for small-diameter applications. We show that tropoelastin enhances endothelial cell attachment (threefold vs. control) and proliferation by 54.7 ± 1...
January 2011: Acta Biomaterialia
#36
COMPARATIVE STUDY
Nasir Shariff, Steven Zelenkofske, Sherrine Eid, Michael J Weiss, Muneeruddin Q Mohammed
BACKGROUND: Atrial fibrillation (AF) occurs in about 27% to 40% of post cardiac surgery patients. AF following coronary artery bypass graft surgery (CABG) is associated with a two-fold increase in morbidity and mortality. Various demographic risk factors and medications have been studied to predict the occurrence of this arrhythmia. The role of angiotensin related medications on the occurrence of AF in CABG patients is not determined. METHODS: Retrospective clinical and statistical analysis was made of all the patients who had undergone CABG surgery at Lehigh Valley Hospital during the years 2005 and 2006...
2010: BMC Cardiovascular Disorders
#37
JOURNAL ARTICLE
P Denoya, H Wang, D Sands, J Nogueras, E Weiss, Steven D Wexner
OBJECTIVE: To investigate the feasibility of laparoscopic total mesorectal excision (TME) in mid and lower rectal cancers following neoadjuvant chemoradiation (nCRT). BACKGROUND: The laparoscopic approach for colon cancer has been widely accepted. A few studies have shown that there are advantages of laparoscopic over open TME surgery for rectal cancer. However, the role of laparoscopy has not been clearly defined specifically in cases following nCRT. METHODS: All patients with rectal cancer who underwent nCRT were identified; no operations for rectal carcinoma were performed laparoscopically between 1997 and 2005...
April 2010: Surgical Endoscopy
#38
JOURNAL ARTICLE
Sherief Shawki, Avraham Belizon, Benjamin Person, Eric G Weiss, Dana R Sands, Steven D Wexner
PURPOSE: Restorative proctocolectomy and ileal pouch-anal anastomosis is the current surgical treatment of choice for most patients with ulcerative colitis. Complications of the ileal pouch may necessitate additional operations to salvage the pouch. The aims of this study were to review the outcomes of reoperative restorative proctocolectomy and ileal pouch-anal anastomosis surgery and to define any predictors of successful pouch salvage surgery. METHODS: The medical records of all patients who underwent reoperative ileoanal pouch surgery for either pouch salvage or pouch excision between 1988 and 2007 were reviewed...
May 2009: Diseases of the Colon and Rectum
#39
COMPARATIVE STUDY
Marat Khaikin, Badma Bashankaev, Benjamin Person, Susan Cera, Dana Sands, Eric Weiss, Juan Nogueras, Anthony Vernava, Steven D Wexner
BACKGROUND: The aim of this study was to compare laparoscopic management of rectal cancer to open surgery. METHODS: The medical records of patients who underwent elective laparoscopic or open proctectomy for rectal cancer between November 2004 and July 2006 were retrospectively reviewed. RESULTS: Thirty-two patients in the laparoscopic group (LG) were matched for tumor location, stage, comorbidity, and type of surgical procedure to 50 patients in the open group (OG)...
April 2009: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
#40
COMPARATIVE STUDY
Chunkang Yang, Steven D Wexner, Bashar Safar, Sanjay Jobanputra, Heiying Jin, Vicky KaMing Li, Juan J Nogueras, Eric G Weiss, Dana R Sands
BACKGROUND: Conversion from laparoscopy to laparotomy can be expected in a variable percentage of surgeries. Patients who experience conversion to a laparotomy may have a worse outcome than those who have a successfully completed laparoscopic procedure. This study aimed to compare the outcomes of converted cases based on whether the case was a reactive conversion (RC, due to an intraoperative complication such as bleeding or bowel injury) or a preemptive conversion (PC, due to a lack of progression or unclear anatomy)...
November 2009: Surgical Endoscopy
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