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Steven Weiss cardiac

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June 2016: Annals of Intensive Care
Nathaniel R Smilowitz, Matthew C Weiss, Rina Mauricio, Asha M Mahajan, Kaitlyn E Dugan, Arvind Devanabanda, Claudia Pulgarin, Eugenia Gianos, Binita Shah, Steven P Sedlis, Martha Radford, Harmony R Reynolds
BACKGROUND: Type 2 myocardial infarction (MI) is defined as myocardial necrosis (myonecrosis) due to an imbalance in supply and demand with clinical evidence of ischemia. Some clinical scenarios of supply-demand mismatch predispose to myonecrosis but limit the identification of symptoms and ECG changes referable to ischemia; therefore, the MI definition may not be met. Factors that predispose to type 2 MI and myonecrosis without definite MI, approaches to treatment, and outcomes remain poorly characterized...
September 1, 2016: International Journal of Cardiology
Peter J Leary, Ryan J Tedford, David A Bluemke, Michael R Bristow, Susan R Heckbert, Steven M Kawut, Eric V Krieger, Joao A Lima, Carolina S Masri, David D Ralph, Steven Shea, Noel S Weiss, Richard A Kronmal
BACKGROUND: Myocardial H2 receptor activation may promote cardiac fibrosis and apoptosis in pre-clinical models and histamine H2 receptor antagonist (H2RA) use may improve symptoms in participants with heart failure (HF); however, relationships between H2RA use, incident HF, and longitudinal change in left ventricular (LV) morphology are not known. OBJECTIVES: This study sought to determine whether H2RA use is associated with incident HF and change in LV morphology over time...
April 5, 2016: Journal of the American College of Cardiology
Bryan Harvell, Nathan Henrie, Amy A Ernst, Steven J Weiss, Scott Oglesbee, Dusadee Sarangarm, Lorenzo Hernandez
BACKGROUND: Troponin elevation can be caused by etiologies other than acute coronary syndromes (ACS). Our hypothesis was that elevated troponins occur more frequently in non-ACS cases but that ACS cases (type 1 ST-elevation myocardial infarction [STEMI] and type 1 non-STEMI [NSTEMI]) have significantly higher troponin elevations. METHODS: This was a cross-sectional cohort analysis of a random subset of all patients with elevated troponins (defined as ≥0.06 ng/mL) over a 1-year period from July 2013 to June 2014...
February 2016: American Journal of Emergency Medicine
Amy C Sturm, Crystal F Kline, Patric Glynn, Benjamin L Johnson, Jerry Curran, Ahmet Kilic, Robert S D Higgins, Philip F Binkley, Paul M L Janssen, Raul Weiss, Subha V Raman, Steven J Fowler, Silvia G Priori, Thomas J Hund, Cynthia A Carnes, Peter J Mohler
BACKGROUND: Identified genetic variants are insufficient to explain all cases of inherited arrhythmia. We tested whether the integration of whole exome sequencing with well-established clinical, translational, and basic science platforms could provide rapid and novel insight into human arrhythmia pathophysiology and disease treatment. METHODS AND RESULTS: We report a proband with recurrent ventricular fibrillation, resistant to standard therapeutic interventions...
May 2015: Journal of the American Heart Association
Steven M Weiss, Jane E Dahlstrom, David A Saint
The cardiac persistent sodium current (IN aP ) presents a novel target for cardiac ischaemic protection. Herein we investigated the effects of the IN aP blocker riluzole in a pig model of regional myocardial ischaemia. Landrace or Large White pigs were subjected to 3 h ligation of the left anterior descending coronary artery (LAD). Pigs received either saline (500 mL/h, i.v.) throughout the experiment (control; n = 7) or riluzole (2 mg/kg in 2 mL propylene glycol in 100 mL saline, i.v.; RIL; n = 7) between 15 and 5 min prior to ligation...
December 2013: Clinical and Experimental Pharmacology & Physiology
Deeptankar DeMazumder, Douglas E Lake, Alan Cheng, Travis J Moss, Eliseo Guallar, Robert G Weiss, Steven R Jones, Gordon F Tomaselli, J Randall Moorman
BACKGROUND: Implantable cardioverter-defibrillators (ICDs), the first line of therapy for preventing sudden cardiac death in high-risk patients, deliver appropriate shocks for termination of ventricular tachycardia (VT)/ventricular fibrillation. A common shortcoming of ICDs is imperfect rhythm discrimination, resulting in the delivery of inappropriate shocks for atrial fibrillation (AF). An underexplored area for rhythm discrimination is the difference in dynamic properties between AF and VT/ventricular fibrillation...
June 2013: Circulation. Arrhythmia and Electrophysiology
Sarah G Nowakowski, Stephen C Kolwicz, Frederick Steven Korte, Zhaoxiong Luo, Jacqueline N Robinson-Hamm, Jennifer L Page, Frank Brozovich, Robert S Weiss, Rong Tian, Charles E Murry, Michael Regnier
We previously demonstrated that cardiac myosin can use 2-deoxy-ATP (dATP) as an energy substrate, that it enhances contraction and relaxation with minimal effect on calcium-handling properties in vitro, and that contractile enhancement occurs with only minor elevation of cellular [dATP]. Here, we report the effect of chronically enhanced dATP concentration on cardiac function using a transgenic mouse that overexpresses the enzyme ribonucleotide reductase (TgRR), which catalyzes the rate-limiting step in de novo deoxyribonucleotide biosynthesis...
April 9, 2013: Proceedings of the National Academy of Sciences of the United States of America
Steven J Kalbfleisch, Jaret Tyler, Raul Weiss
No abstract text is available yet for this article.
July 2012: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Steven M Weiss, David A Saint
BACKGROUND: The potential of the cardiac persistent sodium current as a target for protection of the myocardium from ischaemia and reperfusion injury is gaining increasing interest. We have investigated the anti-ischaemic and antiarrhythmic effects of riluzole, a selective INaP blocker, in an open chest pig model of infarction. METHODS AND PRINCIPAL FINDINGS: The left anterior descending coronary artery (LAD) was ligated in 27 anesthetised pigs (landrace or large white, either sex, 20-35 kg) which had received riluzole (8 mg/kg IP; n = 6), lidocaine (2...
2010: PloS One
Nasir Shariff, Steven Zelenkofske, Sherrine Eid, Michael J Weiss, Muneeruddin Q Mohammed
BACKGROUND: Atrial fibrillation (AF) occurs in about 27% to 40% of post cardiac surgery patients. AF following coronary artery bypass graft surgery (CABG) is associated with a two-fold increase in morbidity and mortality. Various demographic risk factors and medications have been studied to predict the occurrence of this arrhythmia. The role of angiotensin related medications on the occurrence of AF in CABG patients is not determined. METHODS: Retrospective clinical and statistical analysis was made of all the patients who had undergone CABG surgery at Lehigh Valley Hospital during the years 2005 and 2006...
2010: BMC Cardiovascular Disorders
Ameya Nayate, Steven A Moore, Robert Weiss, Otar M Taktakishvili, Li-Hsien Lin, William T Talman
Humans with central lesions that augment sympathetic nerve activity are predisposed to cardiac arrhythmias, myocardial lesions, and sudden death. Previously, we showed that selectively killing neurons with neurokinin-1 receptors in the nucleus tractus solitarii (NTS) of rats attenuated the baroreflex and, in some animals, led to sudden unexplained death within approximately 2 wk. Interruption of arterial baroreflexes is known to increase sympathetic activity. Here we tested the hypothesis that lesions in the NTS lead to fatal cardiac arrhythmias and myocardial lesions...
February 2009: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Yoram Rudy, Michael J Ackerman, Donald M Bers, Colleen E Clancy, Steven R Houser, Barry London, Andrew D McCulloch, Dennis A Przywara, Randall L Rasmusson, R John Solaro, Natalia A Trayanova, David R Van Wagoner, András Varró, James N Weiss, David A Lathrop
The National Heart, Lung, and Blood Institute (NHLBI) convened a workshop of cardiologists, cardiac electrophysiologists, cell biophysicists, and computational modelers on August 20 and 21, 2007, in Washington, DC, to advise the NHLBI on new research directions needed to develop integrative approaches to elucidate human cardiac function. The workshop strove to identify limitations in the use of data from nonhuman animal species for elucidation of human electromechanical function/activity and to identify what specific information on ion channel kinetics, calcium handling, and dynamic changes in the intracellular/extracellular milieu is needed from human cardiac tissues to develop more robust computational models of human cardiac electromechanical activity...
September 9, 2008: Circulation
Miriam M Treggiari, Veena Karir, N David Yanez, Noel S Weiss, Stephen Daniel, Steven A Deem
INTRODUCTION: Intensive insulin therapy (IIT) with tight glycemic control may reduce mortality and morbidity in critically ill patients and has been widely adopted in practice throughout the world. However, there is only one randomized controlled trial showing unequivocal benefit to this approach and that study population was dominated by post-cardiac surgery patients. We aimed to determine the association between IIT and mortality in a mixed population of critically ill patients. METHODS: We conducted a cohort study comparing three consecutive time periods before and after IIT protocol implementation in a Level 1 trauma center: period I (no protocol); period II, target glucose 80 to 130 mg/dL; and period III, target glucose 80 to 110 mg/dL...
2008: Critical Care: the Official Journal of the Critical Care Forum
Sarah Kaplan, Wilbert S Aronow, Chul Ahn, Hoang Lai, Albert J DeLuca, Melvin B Weiss, Hajir Dilmanian, David Spielvogel, Steven L Lansman, Robert N Belkin
The prevalence of an enlarged ascending thoracic aortic diameter (AAD) diagnosed by 2-dimensional echocardiography compared with 64-slice cardiac computed tomography (MSCT) was investigated in 97 women and 117 men (mean age 65 +/- 12 years). Enlarged AADs were diagnosed in 42 of 214 patients (20%) by echocardiography and in 45 of 214 patients (21%) by MSCT (p = NS). The sensitivity, specificity, positive predictive value, and negative predictive value of echocardiography in diagnosing an enlarged AAD using MSCT were 69%, 93%, 74%, and 92%, respectively...
January 1, 2008: American Journal of Cardiology
Sarah Kaplan, Wilbert S Aronow, Hoang Lai, Albert J DeLuca, Melvin B Weiss, Hajir Dilmanian, David Spielvogel, Steven L Lansman, Robert N Belkin
The prevalence of increased ascending thoracic aortic diameter (AAD) and increased descending thoracic aortic diameter (DAD) diagnosed using multislice cardiac computed tomography was investigated in 624 consecutive patients at an academic cardiology practice in 2006. Increased AAD (>3.7 cm) was present in 71 of 361 men (20%) and in 23 of 263 women (9%) (p <0.001). Increased DAD (>3.0 cm) was present in 26 of 339 men (8%) and in 8 of 258 women (3%) (p <0.02). Increased AAD was present in (1) 7 of 96 patients (7%) aged 23 to 50 years, (2) 22 of 234 patients (9%) aged 51 to 65 years, (3) 53 of 263 patients (20%) aged 66 to 80 years, and (4) 12 of 31 patients (39%) aged 81 to 88 years (p <0...
November 15, 2007: American Journal of Cardiology
Rodolfo Ventura, Hanno U Klemm, Thomas Rostock, Boris Lutomsky, Tim Risius, Daniel Steven, Christian Weiss, Thomas Meinertz, Stephan Willems
OBJECTIVE: Catheter ablation of ventricular tachycardia (VT) after myocardial infarction (MI) can be complex and time-consuming. We only targeted the previously documented VTs and those with similar or longer cycle lengths. METHODS: 30 patients with VTs after MI were included in the study. Voltage mapping was performed using an electro-anatomic mapping system (CARTOT). Stable VTs were mapped during tachycardia and unstable VTs during sinus rhythm. RESULTS: Clinical VTs were stable in 16 (53%) and unstable in 14 (47%) patients, and ablation was successful in 11 (69%) and 9 patients (64%), respectively (p = 0...
2008: Cardiology
Stephan Baldus, Kai Müllerleile, Phil Chumley, Daniel Steven, Volker Rudolph, Gunnar K Lund, Hans-Jürgen Staude, Alexander Stork, Ralf Köster, Jan Kähler, Christian Weiss, Thomas Münzel, Thomas Meinertz, Bruce A Freeman, Thomas Heitzer
Reactive oxygen species, in particular superoxide, have been closely linked to the underlying pathophysiology of ischemic cardiomyopathy: superoxide not only mediates mechanoenergetic uncoupling of the myocyte but also adversely impacts on myocardial perfusion by depleting endothelial-derived nitric oxide bioavailability. Xanthine oxidase generates superoxide upon oxidation of hypoxanthine and xanthine and has been detected in cardiac myocytes and coronary endothelial cells of patients with ischemic heart disease...
October 15, 2006: Free Radical Biology & Medicine
Craig S Smith, Paul A Bottomley, Steven P Schulman, Gary Gerstenblith, Robert G Weiss
BACKGROUND: The progression of pressure-overload left ventricular hypertrophy (LVH) to chronic heart failure (CHF) may involve a relative deficit in energy supply and/or delivery. METHODS AND RESULTS: We measured myocardial creatine kinase (CK) metabolite concentrations and adenosine triphosphate (ATP) synthesis through CK, the primary energy reserve of the heart, to test the hypothesis that ATP flux through CK is impaired in patients with LVH and CHF. Myocardial ATP levels were normal, but creatine phosphate levels were 35% lower in LVH patients (n = 10) than in normal subjects (n = 14, P < 0...
September 12, 2006: Circulation
Emile G Daoud, Raul Weiss, Ralph Augostini, John D Hummel, Steven J Kalbfleisch, John M Van Deren, Georgia Dawson, Kathy Bowman
BACKGROUND: After circumferential ablation for atrial fibrillation, new onset left atrial flutter (LA Flr) may occur. This study assessed the relationship between induced and clinical episodes of LA Flr, the rate of spontaneous resolution of LA Flr, and the proarrhythmic effect of circumferential ablation. METHODS AND RESULTS: A total 112 patients underwent circumferential LA ablation for atrial fibrillation. Immediately after completion of the ablation, LA Flr was induced in 43 of 112 (38%) patients, but was not targeted for ablation...
February 2006: Journal of Cardiovascular Electrophysiology
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