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https://www.readbyqxmd.com/read/27625684/evaluation-of-safety-and-efficacy-of-nexgen-an-ultrathin-strut-and-hybrid-cell-design-cobalt-chromium-bare-metal-stent-implanted-in-a-real-life-patient-population-the-polish-nexgen-registry
#1
Krzysztof Milewski, Paweł Gąsior, Stefan Samborski, Piotr P Buszman, Aleksandra Błachut, Adam Wojtaszczyk, Adam Młodziankowski, Artur Mendyk, Marek Król, Wojciech Wojakowski, Paweł E Buszman
INTRODUCTION: Despite the dominance of drug-eluting stents in modern interventional cardiology, there is still a niche for bare metal stents. AIM: The aim of the Polish NexGen registry was to evaluate the safety and efficacy of a new generation cobalt-chromium NexGen stent in a real life patient population. MATERIAL AND METHODS: A prospective multi-center registry was conducted in five clinical sites of American Heart of Poland. Three hundred and eighty-three patients who underwent percutaneous coronary intervention (PCI) with NexGen stent implantation were included...
2016: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/26892080/left-main-stenting-in-comparison-with-surgical-revascularization-10-year-outcomes-of-the-left-main-coronary-artery-stenting-le-mans-trial
#2
Pawel E Buszman, Piotr P Buszman, Iwona Banasiewicz-Szkróbka, Krzysztof P Milewski, Aleksander Żurakowski, Bartłomiej Orlik, Magda Konkolewska, Błażej Trela, Adam Janas, Jack L Martin, R Stefan Kiesz, Andrzej Bochenek
OBJECTIVES: This study has reported 10-year clinical follow-up of patients enrolled in the prospective, randomized LE MANS (Left Main Stenting) trial. BACKGROUND: The very long-term outcome after left main stenting in comparison with surgical revascularization remains unknown. METHODS: In this prospective, multicenter trial, we randomly assigned 105 patients with unprotected left main coronary artery stenosis with low and medium complexity of coexisting coronary artery disease according to SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score to percutaneous coronary intervention (PCI) with stenting (n = 52) or coronary artery bypass grafting (CABG) (n = 53)...
February 22, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/25442993/outcomes-of-surgery-for-chronic-type-a-aortic-dissection
#3
Bartosz Rylski, Rita K Milewski, Joseph E Bavaria, Emanuela Branchetti, Prashanth Vallabhajosyula, Wilson Y Szeto, Nimesh D Desai
BACKGROUND: Data on outcomes of surgery for chronic Stanford type A aortic dissection are limited. We investigated the primary surgery and long-term results in patients with chronic dissection of the native ascending aorta. METHODS: Between 1993 and 2013, among 696 patients (median age, 61 years [first quartile, 50; third quartile 73 years]; 64% males) who underwent surgery for type A dissection, 67 (10%) had chronic dissection by traditional criteria (>14 days)...
January 2015: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/25394877/eptifibatide-infusion-versus-placebo-in-high-risk-patients-with-non-st-segment-elevation-acute-coronary-syndromes-managed-with-urgent-coronary-artery-bypass-graft-surgery-a-prospective-multicenter-randomized-placebo-controlled-clinical-trial
#4
M Wilczynski, M T Wybraniec, K Milewski, M Sanak, K Wita, L Buldak, M Kondys, P Buszman, A Bochenek
AIM: This randomized prospective clinical trial aimed to evaluate safety and efficacy of preoperative use of eptifibatide in high risk patients with non--ST--segment elevation acute coronary syndrome (NSTE--ACS), requiring urgent coronary artery bypass graft surgery (CABG). METHODS: A total of 140 patients with NSTE--ACS eligible for urgent surgical revascularization received either eptifibatide (bolus plus infusion) 12--48 hours prior to surgery (n=72 patients) or placebo (normal saline; n=68 patients) followed by routinely administered enoxaparin and aspirin...
November 14, 2014: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/25124186/comparison-of-stenting-and-surgical-revascularization-strategy-in-non-st-elevation-acute-coronary-syndromes-and-complex-coronary-artery-disease-from-the-milestone-registry
#5
RANDOMIZED CONTROLLED TRIAL
Pawel E Buszman, Piotr P Buszman, Andrzej Bochenek, Marek Gierlotka, Mariusz Gąsior, Krzysztof Milewski, Bartłomiej Orlik, Adam Janas, Wojciech Wojakowski, R Stefan Kiesz, Marian Zembala, Lech Poloński
The optimal revascularization strategy in patients with complex coronary artery disease and non-ST-segment elevation acute coronary syndromes is undetermined. In this multicenter, prospective registry, 4,566 patients with non-ST-segment elevation myocardial infarctions, unstable angina, and multivessel coronary disease, including left main disease, were enrolled. After angiography, 3,033 patients were selected for stenting (10.3% received drug-eluting stents) and 1,533 for coronary artery bypass grafting. Propensity scores were used for baseline characteristic matching and result adjustment...
October 1, 2014: American Journal of Cardiology
https://www.readbyqxmd.com/read/24762037/development-of-a-single-endovascular-device-for-aortic-valve-replacement-and-ascending-aortic-repair
#6
Bartosz Rylski, Wilson Y Szeto, Joseph E Bavaria, Emanuela Branchetti, William Moser, Rita K Milewski
BACKGROUND AND AIM OF THE STUDY: Transcatheter aortic valve implantation (TAVI) is contraindicated in the presence of an ascending aortic aneurysm. Our aim was to design a composite endovascular device enabling ascending aortic repair and TAVI. METHODS: From 2007 to 2013, among 1196 patients with severe aortic stenosis screened for TAVI, 79 nonbicuspid patients had ascending aortic diameter >45 mm. Proximal aortic geometry was assessed in those with computed tomography angiography...
May 2014: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/24629304/type-a-aortic-dissection-after-previous-cardiac-surgery-results-of-an-integrated-surgical-approach
#7
COMPARATIVE STUDY
Bartosz Rylski, Nimesh D Desai, Joseph E Bavaria, William Moser, Prashanth Vallabhajosyula, Alberto Pochettino, Wilson Y Szeto, Rita K Milewski
BACKGROUND: Stanford type A aortic dissection in patients with previous cardiac surgery (PCS) is a catastrophic disease. This investigation evaluates the results of a standardized integrated approach to type A dissection after PCS. METHODS: Between 1993 and 2013, 629 patients with acute type A dissection (median age 61 [50 to 73] years, 64% males) underwent aortic repair utilizing a standardized integrated approach. Of these, 56 (9%) patients had PCS. Median follow-up was 4...
May 2014: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/24534676/surgical-treatment-of-bicuspid-aortic-valve-disease-knowledge-gaps-and-research-perspectives
#8
REVIEW
Alessandro Della Corte, Simon C Body, Anna M Booher, Hans-Joachim Schaefers, Rita K Milewski, Hector I Michelena, Arturo Evangelista, Philippe Pibarot, Patrick Mathieu, Giuseppe Limongelli, Prem S Shekar, Sary F Aranki, Andrea Ballotta, Giuseppe Di Benedetto, Natzi Sakalihasan, Gianantonio Nappi, Kim A Eagle, Joseph E Bavaria, Alessandro Frigiola, Thoralf M Sundt
No abstract text is available yet for this article.
June 2014: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/24332105/quantitative-analysis-of-3-dimensional-aortic-annular-geometry-implication-for-aortic-root-reimplantation
#9
Liam P Ryan, Melissa M Levack, Joseph H Gorman, Robert C Gorman, Rita C Milewski, Joseph E Bavaria
No abstract text is available yet for this article.
March 2014: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/24069144/polymorphism-of-9p21-3-locus-is-associated-with-5-year-survival-in-high-risk-patients-with-myocardial-infarction
#10
Anna Szpakowicz, Witold Pepinski, Ewa Waszkiewicz, Dominika Maciorkowska, Małgorzata Skawronska, Anna Niemcunowicz-Janica, Robert Milewski, Sławomir Dobrzycki, Włodzimierz Jerzy Musial, Karol Adam Kaminski
OBJECTIVE: The rs1333049, rs10757278 and rs4977574 are single nucleotide polymorphisms (SNPs) of chromosome 9p21 locus that are associated with prevalence of acute coronary syndromes (ACS). The rs1333049 SNP was also associated with cardiac outcome 6 months post ACS. No data concerning their association with long term prognosis after myocardial infarction is available. The aim of our study was to investigate the association of the 9p21.3 locus with 5-year overall mortality in patients with ST-elevation myocardial infarction (STEMI) treated invasively...
2013: PloS One
https://www.readbyqxmd.com/read/23849412/benefits-of-standardizing-the-treatment-of-arrhythmias-in-the-sheep-ovis-aries-model-of-chronic-heart-failure-after-myocardial-infarction
#11
Adrienne Dardenne, Carlos Fernandez, Alyssa Wagner, Krzysztof Milewski, Diane R Ordanes, Patricia A Mount, Yanping Cheng, Geng-Hua Yi, Gerard B Conditt, Armando Tellez, Greg L Kaluza, Juan F Granada, William P Feeney
Large animal models of heart failure are essential in preclinical device testing. In sheep, catheter-based coil embolization of the left anterior descending and diagonal artery provides a minimally invasive and reproducible model of myocardial infarction (MI). Although widely used, this model has historically been plagued with a 30% mortality rate, both in the literature and in our own experience. Our study endeavored to decrease the mortality rate by targeting the most common cause of death, intractable arrhythmias, during creation of the ovine MI model...
2013: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/22669133/plaque-sealing-and-passivation-with-a-mechanical-self-expanding-low-outward-force-nitinol-vshield-device-for-the-treatment-of-ivus-and-oct-derived-thin-cap-fibroatheromas-tcfas-in-native-coronary-arteries-report-of-the-pilot-study-vshield-evaluated-at-cardiac
#12
RANDOMIZED CONTROLLED TRIAL
Joanna J Wykrzykowska, Roberto Diletti, Juan Luis Gutierrez-Chico, Robert Jan van Geuns, Wim J van der Giessen, Steven Ramcharitar, H Eric Duckers, Carl Schultz, Pim de Feyter, Martin van der Ent, Evelyn Regar, Peter de Jaegere, Hector M Garcia-Garcia, Rawindra Pawar, Nieves Gonzalo, Jurgen Ligthart, Jean de Schepper, Nico van den Berg, Krzysztof Milewski, Juan F Granada, Patrick W Serruys
AIMS: The aim of the pilot SECRITT trial was to evaluate the safety and feasibility of sealing the high risk IVUS and optical coherence tomography-derived thin cap fibroatheroma (TCFA), with a dedicated nitinol self-expanding vShield device. METHODS AND RESULTS: After screening with angiography, fractional flow reserve (FFR), intravascular ultrasound virtual histology (IVUS-VH) and optical coherence tomography (OCT), 23 patients met enrolment criteria (presence of non-obstructive VH-derived TCFA lesion with thin cap on OCT) and were randomised to vShield (n=13) versus medical therapy (n=10)...
December 20, 2012: EuroIntervention
https://www.readbyqxmd.com/read/22511557/long-term-effects-on-vascular-healing-of-bare-metal-stents-delivered-via-paclitaxel-coated-balloons-in-the-porcine-model-of-restenosis
#13
COMPARATIVE STUDY
Bodo Cremers, Krzysztof Milewski, Yvonne P Clever, Michael S Aboodi, Melanie Biedermann, Troels Thim, Bettina Kelsch, Greg L Kaluza, Bruno Scheller, Juan F Granada
BACKGROUND: Clinical trials have consistently demonstrated benefits of paclitaxel-coated balloons (PCB) in particular clinical situations such as in-stent restenosis and peripheral vascular interventions. However, the long-term vascular effects of bare metal stents (BMS) delivered via PCB (PCB+BMS) are still unknown. The aim of this study was to assess the long-term effects of PCB+BMS on vascular healing and neointimal formation (NF). METHODS: A total of 208 stents: 56 BMS crimped on PCB, 50 BMS crimped on uncoated balloons (UCB+BMS), 52 Taxus and 50 Cypher stents were implanted in normal coronary arteries of 104 pigs using 1...
October 1, 2012: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/22082574/first-clinical-evaluation-of-a-luminal-self-expanding-shield-in-patients-with-intermediate-coronary-lesions
#14
Juan F Granada, Krzysztof Milewski, Maria P Uribe, Miguel Moncada, Andres Fernandez, Guillermo Blanco, Greg L Kaluza, Joanna J Wykrzykowska, Patrick W Serruys, Gregg W Stone, Juan A Delgado
AIMS: Earlier generation self-expanding stents (SExS) showed high restenosis rates and long-term stent over-expansion. A novel SExS with reduced outward expansive force has been developed to overcome these limitations. This first-in-human study aimed to evaluate the safety and feasibility of the low pressure self-expanding nitinol-based vProtect™ luminal shield (LS) in the treatment of intermediate coronary lesions. METHODS AND RESULTS: A total of 29 patients with clinical evidence of myocardial ischaemia and intermediate de novo coronary lesions were included...
November 2011: EuroIntervention
https://www.readbyqxmd.com/read/21421185/effects-of-local-intracoronary-paclitaxel-delivery-using-the-remedy-transport-catheter-on-neointimal-hyperplasia-after-stent-implantation-in-a-porcine-model
#15
COMPARATIVE STUDY
Krzysztof Milewski, Aleksander Zurakowski, Jacek Pajak, Lukasz Liszka, Marcin Debinski, Piotr P Buszman, Motaz Abu Samra, Piotr Dominek, Michael S Aboodi, Grzegorz L Kaluza, Pawel Buszman
PURPOSE: To assess the effects of local paclitaxel delivery using the Remedy catheter on neointimal hyperplasia in a porcine model and compare these results to commercially available BMS and biodegradable polymer-coated paclitaxel-eluting stents (BP-PES). METHODS AND MATERIALS: A total of 31 stents were implanted into coronary arteries of 15 domestic swine including eight BMS, six BP-PES, and 17 BMS after intravasal paclitaxel delivery at doses of 250 μg (LPD250; n=9) and 500 μg (LPD500, n=6)...
March 2011: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/21292932/lyme-disease-and-the-orthopaedic-implications-of-lyme-arthritis
#16
REVIEW
Brian G Smith, Aristides I Cruz, Matthew D Milewski, Eugene D Shapiro
Lyme disease is the most common tick-borne disease in the United States and Europe. Increased awareness of the clinical manifestations of the disease is needed to improve detection and treatment. In the acute and late stages, Lyme disease may be difficult to distinguish from other disease processes. The epidemiology and pathophysiology of Lyme disease are directly related to the Borrelia burgdorferi spirochete and its effects on the integumentary, neurologic, cardiac, and musculoskeletal systems. Lyme arthritis is a common clinical manifestation of Lyme disease and should be considered in the evaluation of patients with monoarticular or pauciarticular joint complaints in a geographic area in which Lyme disease is endemic...
February 2011: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/21146678/comparison-of-adverse-cardiovascular-events-and-bleeding-complications-of-loading-dose-of-clopidogrel-300-mg-versus-600-mg-in-stable-patients-undergoing-elective-percutaneous-intervention-from-the-cadice-study
#17
RANDOMIZED CONTROLLED TRIAL
Andres Fernandez, Michael S Aboodi, Krzysztof Milewski, Juan A Delgado, Arturo Rodríguez, Juan F Granada
In large clinical trials enrolling patients with acute coronary syndromes, a high loading dose of clopidogrel (600 mg) has been found to be more effective compared to a low loading dose (300 mg). However, the applicability of these data to stable patients who undergo elective percutaneous coronary intervention is still unclear. A total of 400 patients who underwent elective PCI were prospectively randomized to receive either 600 mg (n = 200) or 300 mg (n = 200) of clopidogrel, followed by a daily maintenance dose of 75 mg...
January 2011: American Journal of Cardiology
https://www.readbyqxmd.com/read/20596650/cardiomyocyte-differentiation-of-bone-marrow-derived-oct-4-cxcr4-ssea-1-very-small-embryonic-like-stem-cells
#18
Wojciech Wojakowski, Michal Tendera, Magda Kucia, Ewa Zuba-Surma, Krzysztof Milewski, David Wallace-Bradley, Maciej Kazmierski, Pawel Buszman, Eugeniusz Hrycek, Wieslaw Cybulski, Grzegorz Kaluza, Piotr Wieczorek, Janina Ratajczak, Mariusz Z Ratajczak
VSELs are a population of rare Oct-4+CXCR4+ CD133+lin-CD45- cells that are deposited during early embryogenesis in developing organs/tissues as a reserve population of pluripotent stem cells for regeneration. We reported recently that they are mobilized into peripheral blood during acute myocardial infarction (AMI) in mice and humans. However, although freshly isolated VSELs in experimental AMI mouse models improve cardiac function, the number of these cells is limited and an ex vivo expansion strategy is needed to employ these cells more efficiently for cardiac regeneration...
August 2010: International Journal of Oncology
https://www.readbyqxmd.com/read/18690568/-congestive-cardiomyopathy-and-left-intraventricular-thrombus-as-a-manifestation-of-churg-strauss-syndrome
#19
Jerzy Dropiński, Wojceich Szczeklik, Barbara Sokołowska, Magdalena Celińska-Lowenhoff, Mamert Milewski, Andrzej Szczeklik
A case of a 38-year-old female with symptomatic Churg-Strauss syndrome and congestive cardiomyopathy, complicated by cardiac arrest and left ventricular thrombus formation, is presented. Prompt institution of low molecular weight heparin and steroids resulted in rapid thrombus lysis and improvement of systolic left ventricular function.
July 2008: Kardiologia Polska
https://www.readbyqxmd.com/read/18237682/acute-and-late-outcomes-of-unprotected-left-main-stenting-in-comparison-with-surgical-revascularization
#20
RANDOMIZED CONTROLLED TRIAL
Pawel E Buszman, Stefan R Kiesz, Andrzej Bochenek, Ewa Peszek-Przybyla, Iwona Szkrobka, Marcin Debinski, Bozena Bialkowska, Dariusz Dudek, Agata Gruszka, Aleksander Zurakowski, Krzysztof Milewski, Miroslaw Wilczynski, Lukasz Rzeszutko, Piotr Buszman, Jan Szymszal, Jack L Martin, Michal Tendera
OBJECTIVES: The purpose of this study was to compare the early and late results of percutaneous and surgical revascularization of left main coronary artery stenosis. BACKGROUND: Unprotected left main coronary artery (ULMCA) stenting is being investigated as an alternative to bypass surgery. METHODS: We randomly assigned 105 patients with ULMCA stenosis to percutaneous coronary intervention (PCI; 52 patients) or coronary artery bypass grafting (CABG; 53 patients)...
February 5, 2008: Journal of the American College of Cardiology
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