Read by QxMD icon Read

R Milewski

Andrew R Milewski, Dáibhid Ó Maoiléidigh, Joshua D Salvi, A J Hudspeth
Our sense of hearing boasts exquisite sensitivity, precise frequency discrimination, and a broad dynamic range. Experiments and modeling imply, however, that the auditory system achieves this performance for only a narrow range of parameter values. Small changes in these values could compromise hair cells' ability to detect stimuli. We propose that, rather than exerting tight control over parameters, the auditory system uses a homeostatic mechanism that increases the robustness of its operation to variation in parameter values...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
J M Diamond, E Cantu, M K Porteous, Y Suzuki, K C Meyer, D J Lederer, R K Milewski, S Arcasoy, F D'Ovidio, M Bacchetta, J R Sonett, G Singh, J Costa, J W Tobias, H Rodriguez, V M Van Deerlin, K M Olthoff, A Shaked, B-L Chang, J D Christie
Recipient responses to primary graft dysfunction (PGD) after lung transplantation may have important implications to the fate of the allograft. We therefore evaluated longitudinal differences in peripheral blood gene expression in subjects with PGD. RNA expression was measured throughout the first transplant year in 106 subjects enrolled in the Clinical Trials in Organ Transplantation-03 study using a panel of 100 hypothesis-driven genes. PGD was defined as grade 3 in the first 72 posttransplant hours. Eighteen genes were differentially expressed over the first year based on PGD development, with significant representation from innate and adaptive immunity genes, with most differences identified very early after transplant...
July 2017: American Journal of Transplantation
Yinian Zhang, Daniel P Seeburg, Benjamin Pulli, Gregory R Wojtkiewicz, Lionel Bure, Wendy Atkinson, Stefan Schob, Yoshiko Iwamoto, Muhammad Ali, Wei Zhang, Elisenda Rodriguez, Andrew Milewski, Edmund J Keliher, Cuihua Wang, Yawen Pan, Filip K Swirski, John W Chen
No abstract text is available yet for this article.
February 2017: Radiology
A J Ziecik, J Klos, E Przygrodzka, R Milewski, B Jana
Research was conducted to determine the effect of altrenogest and exposure to exogenous gonadotropins on ovarian function in prepubertal and mature gilts. Crossbred, presumably sexually mature gilts (n = 51), were fed with altrenogest for 18 consecutive days and the day after the last feeding with altrenogest, gilts were treated with eCG and 72 hours later challenged with hCG. Animals were slaughtered on Days 10 to 13 of their gonadotropins synchronized estrous cycle. Ovaries were examined for the number of CL, number of follicular cysts, and presence of corpora albicantia...
February 2017: Theriogenology
Adam Janas, Piotr Buszman, Krzysztof Milewski, Marek Król, Wojciech Fil, Wojtek Wojakowski, Przemek Nowakowski, Aleksandra Blachut, Maciej Pruski, Pawel Buszman, R Stefan Kiesz
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
Neeraj Sharma, Jessica LaRusch, Patrick R Sosnay, Laura B Gottschalk, Andrea P Lopez, Matthew J Pellicore, Taylor Evans, Emily Davis, Melis Atalar, Chan-Hyun Na, Gedge D Rosson, Deborah Belchis, Michal Milewski, Akhilesh Pandey, Garry R Cutting
The development of cystic fibrosis transmembrane conductance regulator (CFTR) targeted therapy for cystic fibrosis has generated interest in maximizing membrane residence of mutant forms of CFTR by manipulating interactions with scaffold proteins, such as sodium/hydrogen exchange regulatory factor-1 (NHERF1). In this study, we explored whether COOH-terminal sequences in CFTR beyond the PDZ-binding motif influence its interaction with NHERF1. NHERF1 displayed minimal self-association in blot overlays (NHERF1, Kd = 1,382 ± 61...
December 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
A A Abbas, J M Diamond, C Chehoud, B Chang, J J Kotzin, J C Young, I Imai, A R Haas, E Cantu, D J Lederer, K C Meyer, R K Milewski, K M Olthoff, A Shaked, J D Christie, F D Bushman, R G Collman
Primary graft dysfunction (PGD) is a principal cause of early morbidity and mortality after lung transplantation, but its pathogenic mechanisms are not fully clarified. To date, studies using standard clinical assays have not linked microbial factors to PGD. We previously used comprehensive metagenomic methods to characterize viruses in lung allografts >1 mo after transplant and found that levels of Anellovirus, mainly torque teno viruses (TTVs), were significantly higher than in nontransplanted healthy controls...
May 2017: American Journal of Transplantation
Elizabeth H Marchlewicz, Dana C Dolinoy, Lu Tang, Samantha Milewski, Tamara R Jones, Jaclyn M Goodrich, Tanu Soni, Steven E Domino, Peter X K Song, Charles F Burant, Vasantha Padmanabhan
Maternal diet and metabolism impact fetal development. Epigenetic reprogramming facilitates fetal adaptation to these in utero cues. To determine if maternal metabolite levels impact infant DNA methylation globally and at growth and development genes, we followed a clinical birth cohort of 40 mother-infant dyads. Targeted metabolomics and quantitative DNA methylation were analyzed in 1st trimester maternal plasma (M1) and delivery maternal plasma (M2) as well as infant umbilical cord blood plasma (CB). We found very long chain fatty acids, medium chain acylcarnitines, and histidine were: (1) stable in maternal plasma from pregnancy to delivery, (2) significantly correlated between M1, M2, and CB, and (3) in the top 10% of maternal metabolites correlating with infant DNA methylation, suggesting maternal metabolites associated with infant DNA methylation are tightly controlled...
October 7, 2016: Scientific Reports
Agnieszka Adamska, Monika Karczewska-Kupczewska, Agnieszka Lebkowska, Robert Milewski, Maria Górska, Elzbieta Otziomek, Agnieszka Nikolajuk, Slawomir Wolczynski, Irina Kowalska
Irisin is an adipokine/myokine which could be connected with insulin sensitivity. Polycystic ovary syndrome (PCOS) is characterized by oligo- or anovulation, polycystic ovary, hyperandrogenism and insulin resistance. The aim of the present study was to determine the relationship between serum irisin concentration and insulin sensitivity (Mffm) as well as the effect of insulin infusion on circulating irisin levels in PCOS women as compared with healthy controls. Seventy seven women were enrolled in the study - 57 with PCOS and 20 healthy controls matched for BMI and age...
December 30, 2016: Endocrine Journal
Jonathan W Weinsaft, Richard B Devereux, Liliana R Preiss, Attila Feher, Mary J Roman, Craig T Basson, Alexi Geevarghese, William Ravekes, Harry C Dietz, Kathryn Holmes, Jennifer Habashi, Reed E Pyeritz, Joseph Bavaria, Karianna Milewski, Scott A LeMaire, Shaine Morris, Dianna M Milewicz, Siddharth Prakash, Cheryl Maslen, Howard K Song, G Michael Silberbach, Ralph V Shohet, Nazli McDonnell, Tabitha Hendershot, Kim A Eagle, Federico M Asch
BACKGROUND: Aortic dissection (AoD) is a serious complication of thoracic aortic aneurysm (TAA). Relative risk for AoD in relation to TAA etiology, incidence, and pattern after prophylactic TAA surgery are poorly understood. OBJECTIVES: This study sought to determine the incidence, pattern, and relative risk for AoD among patients with genetically associated TAA. METHODS: The population included adult GenTAC participants without AoD at baseline...
June 14, 2016: Journal of the American College of Cardiology
Krzysztof Milewski, Wojciech Fil, Piotr Buszman, Małgorzata Janik, Wojciech Wanha, Todd Martin, Marek Król, Bogdan Gorycki, Szymon Wiernek, Lukasz Krzych, R Stefan Kiesz, Wojciech Wojakowski, Paweł Buszman
BACKGROUND/AIMS: Clinical benefits of percutaneous treatment of renal artery stenosis (RAS) remain controversial. The aim of this study was to evaluate the effects of renal artery stenting on kidney function and blood pressure (BP) control in the log-term follow-up. Additionally angiographic follow up was performed in selected subgroup of patients. METHODS: The study was designed as international registry of 265 consecutive patients with RAS treated with renal artery stenting...
2016: Kidney & Blood Pressure Research
Agnieszka Łebkowska, Agnieszka Adamska, Monika Karczewska-Kupczewska, Agnieszka Nikołajuk, Elżbieta Otziomek, Robert Milewski, Maria Górska, Sławomir Wołczyński, Irina Kowalska
PURPOSE: A single prior study conducted in Chilean women has shown that women with type 1 diabetes mellitus (T1DM) and polycystic ovary syndrome (PCOS) have a normal serum anti-Müllerian hormone (AMH) concentrations despite polycystic ovarian morphology. As it is not clear why women with PCOS+T1DM would not have an elevated concentrations of AMH, we hypothesize that women with T1DM and PCOS have a similar hormonal profile and serum AMH levels as is observed in classic PCOS. METHODS: We studied 89 women: 37 with T1DM (16 with PCOS+T1DM, 21 with T1DM/no-PCOS), 36 with PCOS (PCOS) and 16 healthy women (control group) matched for age and body mass index (BMI)...
May 2016: Metabolism: Clinical and Experimental
Pawel E Buszman, Piotr P Buszman, Iwona Banasiewicz-Szkróbka, Krzysztof P Milewski, Aleksander Żurakowski, Bartłomiej Orlik, Magda Konkolewska, Błażej Trela, Adam Janas, Jack L Martin, R Stefan Kiesz, Andrzej Bochenek
OBJECTIVES: This study has reported 10-year clinical follow-up of patients enrolled in the prospective, randomized LE MANS (Left Main Stenting) trial. BACKGROUND: The very long-term outcome after left main stenting in comparison with surgical revascularization remains unknown. METHODS: In this prospective, multicenter trial, we randomly assigned 105 patients with unprotected left main coronary artery stenosis with low and medium complexity of coexisting coronary artery disease according to SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score to percutaneous coronary intervention (PCI) with stenting (n = 52) or coronary artery bypass grafting (CABG) (n = 53)...
February 22, 2016: JACC. Cardiovascular Interventions
Jaroslaw Zalewski, Piet Claus, Jan Bogaert, Nina Vanden Driessche, Ronald B Driesen, Diogo T Galan, Karin R Sipido, Piotr Buszman, Krzysztof Milewski, Frans Van de Werf
Postconditioning and cyclosporine A prevent mitochondrial permeability transition pore opening providing cardioprotection during ischemia/reperfusion. Whether microvascular obstruction is affected by these interventions is largely unknown. Pigs subjected to coronary occlusion for 1 h followed by 3 h of reperfusion were assigned to control (n = 8), postconditioning (n = 9) or cyclosporine A intravenous infusion 10-15 min before the end of ischemia (n = 8). Postconditioning was induced by 8 cycles of repeated 30-s balloon inflation and deflation...
March 2015: Basic Research in Cardiology
R M Mroz, P Lisowski, A Tycinska, J Bierla, P Z Trzeciak, L Minarowski, R Milewski, A Lisowska, P Boros, B Sobkowicz, A M Duszewska, E Chyczewska, W J Musial, W MacNee
UNLABELLED: Observational studies have suggested that statins may have beneficial effects on outcomes in chronic obstructive pulmonary disease (COPD) patients. These effects may be mediated through an anti-inflammatory effect of statins. The purpose of this pilot-study was to determine whether statins have an anti-inflammatory effect on the lungs of COPD patients. We conducted randomized, controlled, parallel group pilot-study to compare the effects of atorvastatin (n=12) or placebo (n=6) on lung inflammation in patients with mild to moderate COPD...
February 2015: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Binfeng Xia, Zhen Yang, Haiying Zhou, Viera Lukacova, Wei Zhu, Mikolaj Milewski, Filippos Kesisoglou
Intraoral (IO) delivery is an alternative administration route to deliver a drug substance via the mouth that provides several advantages over conventional oral dosage forms. The purpose of this work was to develop and evaluate a novel, physiologically based oral cavity model for projection and mechanistic analysis of the clinical pharmacokinetics of intraoral formulations. The GastroPlus™ Oral Cavity Compartmental Absorption and Transit (OCCAT™) model was used to simulate the plasma concentration versus time profiles and the fraction and rate of intraoral drug transit/absorption for Intermezzo® sublingual tablets (zolpidem tartrate)...
May 2015: AAPS Journal
Joji B Kuramatsu, Stefan T Gerner, Peter D Schellinger, Jörg Glahn, Matthias Endres, Jan Sobesky, Julia Flechsenhar, Hermann Neugebauer, Eric Jüttler, Armin Grau, Frederick Palm, Joachim Röther, Peter Michels, Gerhard F Hamann, Joachim Hüwel, Georg Hagemann, Beatrice Barber, Christoph Terborg, Frank Trostdorf, Hansjörg Bäzner, Aletta Roth, Johannes Wöhrle, Moritz Keller, Michael Schwarz, Gernot Reimann, Jens Volkmann, Wolfgang Müllges, Peter Kraft, Joseph Classen, Carsten Hobohm, Markus Horn, Angelika Milewski, Heinz Reichmann, Hauke Schneider, Eik Schimmel, Gereon R Fink, Christian Dohmen, Henning Stetefeld, Otto Witte, Albrecht Günther, Tobias Neumann-Haefelin, Andras E Racs, Martin Nueckel, Frank Erbguth, Stephan P Kloska, Arnd Dörfler, Martin Köhrmann, Stefan Schwab, Hagen B Huttner
IMPORTANCE: Although use of oral anticoagulants (OACs) is increasing, there is a substantial lack of data on how to treat OAC-associated intracerebral hemorrhage (ICH). OBJECTIVE: To assess the association of anticoagulation reversal and blood pressure (BP) with hematoma enlargement and the effects of OAC resumption. DESIGN, SETTING, AND PARTICIPANTS: Retrospective cohort study at 19 German tertiary care centers (2006-2012) including 1176 individuals for analysis of long-term functional outcome, 853 for analysis of hematoma enlargement, and 719 for analysis of OAC resumption...
February 24, 2015: JAMA: the Journal of the American Medical Association
Daniel P Flaherty, Justin R Miller, Danielle M Garshott, Michael Hedrick, Palak Gosalia, Yujie Li, Monika Milewski, Eliot Sugarman, Stefan Vasile, Sumeet Salaniwal, Ying Su, Layton H Smith, Thomas D Y Chung, Anthony B Pinkerton, Jeffrey Aubé, Michael U Callaghan, Jennifer E Golden, Andrew M Fribley, Randal J Kaufman
Cellular proteins that fail to fold properly result in inactive or disfunctional proteins that can have toxic functions. The unfolded protein response (UPR) is a two-tiered cellular mechanism initiated by eukaryotic cells that have accumulated misfolded proteins within the endoplasmic reticulum (ER). An adaptive pathway facilitates the clearance of the undesired proteins; however, if overwhelmed, cells trigger apoptosis by upregulating transcription factors such as C/EBP-homologous protein (CHOP). A high throughput screen was performed directed at identifying compounds that selectively upregulate the apoptotic CHOP pathway while avoiding adaptive signaling cascades, resulting in a sulfonamidebenzamide chemotype that was optimized...
December 11, 2014: ACS Medicinal Chemistry Letters
Howard K Song, Liliana R Preiss, Cheryl L Maslen, Barbara Kroner, Richard B Devereux, Mary J Roman, Kathryn W Holmes, H Eser Tolunay, Patrice Desvigne-Nickens, Federico M Asch, Rita K Milewski, Joseph Bavaria, Scott A LeMaire
BACKGROUND AND AIM OF THE STUDY: The long-term outcomes of aortic valve-sparing (AVS) root replacement in Marfan syndrome (MFS) patients remain uncertain. The study aim was to determine the utilization and outcomes of AVS root replacement in MFS patients enrolled in the Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC). METHODS: At the time of this analysis, 788 patients with MFS were enrolled in the GenTAC Registry, of whom 288 had undergone aortic root replacement...
May 2014: Journal of Heart Valve Disease
Pawel E Buszman, Piotr P Buszman, Andrzej Bochenek, Marek Gierlotka, Mariusz Gąsior, Krzysztof Milewski, Bartłomiej Orlik, Adam Janas, Wojciech Wojakowski, R Stefan Kiesz, Marian Zembala, Lech Poloński
The optimal revascularization strategy in patients with complex coronary artery disease and non-ST-segment elevation acute coronary syndromes is undetermined. In this multicenter, prospective registry, 4,566 patients with non-ST-segment elevation myocardial infarctions, unstable angina, and multivessel coronary disease, including left main disease, were enrolled. After angiography, 3,033 patients were selected for stenting (10.3% received drug-eluting stents) and 1,533 for coronary artery bypass grafting. Propensity scores were used for baseline characteristic matching and result adjustment...
October 1, 2014: American Journal of Cardiology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"