Joshua C Doloff, Omid Veiseh, Roberto de Mezerville, Marcos Sforza, Tracy Ann Perry, Jennifer Haupt, Morgan Jamiel, Courtney Chambers, Amanda Nash, Samira Aghlara-Fotovat, Jessica L Stelzel, Stuart J Bauer, Sarah Y Neshat, John Hancock, Natalia Araujo Romero, Yessica Elizondo Hidalgo, Isaac Mora Leiva, Alexandre Mendonça Munhoz, Ardeshir Bayat, Brian M Kinney, H Courtney Hodges, Roberto N Miranda, Mark W Clemens, Robert Langer
Silicone is widely used in chronic implants and is generally perceived to be safe. However, textured breast implants have been associated with immune-related complications, including malignancies. Here, by examining for up to one year the foreign body response and capsular fibrosis triggered by miniaturized or full-scale clinically approved breast implants with different surface topography (average roughness, 0-90 μm) placed in the mammary fat pads of mice or rabbits, respectively, we show that surface topography mediates immune responses to the implants...
October 2021: Nature Biomedical Engineering