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Haupt cardiac

Desiree Grabow, Melanie Kaiser, Lars Hjorth, Julianne Byrne, Daniela Alessi, Rodrigue S Allodji, Francesca Bagnasco, Edit Bárdi, Andrea Bautz, Chloe J Bright, Florent de Vathaire, Elizabeth A M Feijen, Stanislaw Garwicz, Oskar Hagberg, Riccardo Haupt, Mike M Hawkins, Zsuzsanna Jakab, Leontien C M Kremer, Claudia E Kuehni, Rahel Kuonen, Päivi Maria Lähteenmäki, Raoul C Reulen, Cécile M Ronckers, Carlotta Sacerdote, Giao Vu-Bezin, Finn Wesenberg, Thomas Wiebe, David L Winter, Jeanette Falck Winther, Lorna Zadravec Zaletel, Peter Kaatsch
Childhood cancer survivors face risks from a variety of late effects, including cardiac events, second cancers, and late mortality. The aim of the pan-European PanCare Childhood and Adolescent Cancer Survivor Care and Follow-Up Studies (PanCareSurFup) Consortium was to collect data on incidence and risk factors for these late effects among childhood cancer survivors in Europe. This paper describes the methodology of the data collection for the overall PanCareSurFup cohort and the outcome-related cohorts. In PanCareSurFup 13 data providers from 12 countries delivered data to the data centre in Mainz...
March 2018: European Journal of Epidemiology
Claudia Noack, Luis Peter Haupt, Wolfram-Hubertus Zimmermann, Katrin Streckfuss-Bömeke, Laura Cecilia Zelarayán
Krueppel-like factor 15 (KLF15) is abundantly expressed in liver, kidney, and muscle, including myocardium. In the adult heart KLF15 is important to maintain homeostasis and to repress hypertrophic remodeling. We generated a homozygous hESC KLF15 knockout (KO) line using paired CRISPR/Cas9n. KLF15-KO cells maintained full pluripotency and differentiation potential as well as genomic integrity. We demonstrated that KLF15-KO cells can be differentiated into morphologically normal cardiomyocytes turning them into a valuable tool for studying human KLF15-mediated mechanisms resulting in human cardiac dysfunction...
August 2017: Stem Cell Research
Aschraf El-Essawi, Ingo Breitenbach, Benjamin Haupt, Rene Brouwer, Hassina Baraki, Wolfgang Harringer
OBJECTIVES: Minimally invasive extracorporeal circuits (MiECCs) aim at the preservation of physiologic reserves, the impact of which is expected to be most evident in patients in whom these are depleted. In this context, octogenarians present a subpopulation of specific interest. METHODS: Based on the type of the utilized ECC, we performed a retrospective comparison between all octogenarians (n = 324) who received a primary coronary artery bypass in our institution from 2003 until 2010...
December 1, 2017: European Journal of Cardio-thoracic Surgery
Elizabeth A M Feijen, Anna Font-Gonzalez, Elvira C van Dalen, Helena J H van der Pal, Raoul C Reulen, David L Winter, Claudia E Kuehni, Riccardo Haupt, Daniela Alessi, Julianne Byrne, Edit Bardi, Zsuzsanna Jakab, Desiree Grabow, Stanislaw Garwicz, Momcilo Jankovic, Gill A Levitt, Roderick Skinner, Lorna Zadravec Zaletel, Lars Hjorth, Wim J E Tissing, Florent de Vathaire, Mike M Hawkins, Leontien C M Kremer
BACKGROUND AND AIM: Childhood cancer survivors are at high risk of long-term adverse effects of cancer and its treatment, including cardiac events. The pan-European PanCareSurFup study determined the incidence and risk factors for cardiac events among childhood cancer survivors. The aim of this article is to describe the methodology of the cardiac cohort and nested case-control study within PanCareSurFup. METHODS: Eight data providers in Europe participating in PanCareSurFup identified and validated symptomatic cardiac events in their cohorts of childhood cancer survivors...
2016: PloS One
Michael Huntgeburth, Christoph Adler, Stephan Rosenkranz, Carsten Zobel, Walter F Haupt, Christian Dohmen, Hannes Reuter
BACKGROUND: To determine neurologic outcome in patients with out-of-hospital cardiac arrest (OHCA) and treatment with mild therapeutic hypothermia (MTH). METHODS: Seventy-three consecutive OHCA patients treated with MTH were retrospectively analyzed. Serum neuron-specific enolase (NSE) was measured 24, 48, and 72 h after admission. In patients with no motor response 48 h after termination of analgosedation (n = 40), clinical neurological examination and evoked potentials (EPs) were determined...
June 2014: Neurocritical Care
Vidushi Sharma, Christine Rohr, Susan Sallach, Butchi Babu Paidipaty, Marilyn Haupt
SESSION TYPE: Cancer Student/Resident Case Report PostersPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: The comman Anterior mediastinal masses found in the anterior mediastinum are thymomas, lymphomas, germ cell tumors, congenital cysts, intrathoracic thyroid tissue, and parathyroid lesions1. Common clinical presentations of the mediastinal masses include dyspnea on exertion, arrhythmias, right-sided heart failure, pericarditis, pericardial effusion, and syncope.1 Thymomas represent 20 percent of all mediastinal neoplasms in adults and is found in 15 percent of patients with myasthenia gravis...
October 1, 2012: Chest
F Merkle, B Haupt, A El-Essawi, R Hetzer
The development and improvement of cardiopulmonary bypass technology is an ongoing process. During the past decade, a number of publications on improvements and best practices have appeared, especially in the areas of biocompatibility, materials sciences, instrumentation, monitoring of physiological parameters and knowledge base (education and evidence-based medicine). Biocompatibility may be defined not only as an inherent property of a particular composition of matter, but also as a set of properties concerning shape, finish, fabrication techniques and choice of application...
2012: HSR Proceedings in Intensive Care & Cardiovascular Anesthesia
Mark E Haupt, Denise M Goodman, Stephen H Sheldon
STUDY OBJECTIVES: We describe the respiratory, cardiac, and sleep-related characteristics of two types of sleep-related respiratory pauses in children that can fulfill current criteria of pathological apnea, but often seem to be benign: prolonged expiratory apnea (PEA) and post-sigh central apnea (PSCA). METHODS: All outpatient comprehensive overnight polysomnography completed on children without significant underlying medical conditions completed during an 18-month period were retrospectively reviewed for the presence of augmented breaths followed by a respiratory pause...
December 15, 2012: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Christian Krebs, Christoph Fraune, Robin Schmidt-Haupt, Jan-Eric Turner, Ulf Panzer, Michael N Quang, Andrea Tannapfel, Joachim Velden, Rolf A Stahl, Ulrich O Wenzel
BACKGROUND: CCR5 is expressed on infiltrating T cells in hypertensive mice and CCR5 antagonists reduce hypertension making CCR5 an interesting target in treatment of hypertension. METHODS: To evaluate the role of CCR5 in hypertensive renal and cardiac end-organ damage, we induced hypertension with desoxycorticosterone acetate (DOCA) and angiotensin II (Ang II) in wild-type (WT) and CCR5-deficient mice. RESULTS: CCR5 expression was increased in renal cortex and cardiac tissue as measured by quantitative PCR...
April 2012: American Journal of Hypertension
K Krause, K Jaquet, C Schneider, S Haupt, M V Lioznov, K-M Otte, K-H Kuck
BACKGROUND: Clinical studies on intracoronary stem cell infusion in patients with acute myocardial infarction (AMI) have shown promising results for left ventricular ejection fraction (LVEF). However, preclinical studies have shown that intramyocardial cell injection is better than the intracoronary approach. OBJECTIVE: To test safety and feasibility of intramyocardial cell injection and left ventricular electromechanical mapping (EMM) early after AMI. DESIGN: On day 10...
July 2009: Heart: Official Journal of the British Cardiac Society
Martin Haupt, Alfonso Cruz-Jentoft, Dilip Jeste
Agitation, aggression, and psychosis are among the most troublesome behavioral and psychological symptoms of dementia (BPSD) and impair the lives of dementia patients and their caregivers. Atypical antipsychotics have been widely prescribed to improve these BPSD. However, in a number of trials with atypical antipsychotics, a consistent increase in overall mortality has been observed. The US Food and Drug Administration issued a warning for all atypical antipsychotics as a result of a meta-analysis of 17 placebo-controlled clinical trials using various atypical antipsychotics for the treatment of BSPD...
December 2006: Journal of Clinical Psychopharmacology
No abstract text is available yet for this article.
October 1963: Surgery, Gynecology & Obstetrics
No abstract text is available yet for this article.
October 19, 1963: JAMA: the Journal of the American Medical Association
No abstract text is available yet for this article.
July 13, 1963: JAMA: the Journal of the American Medical Association
Bettina Frey, Wolfram Johnen, Renate Haupt, Hartmut Kern, Bernd Rüstow, Wolfgang J Kox, Michael Schlame
Critical illness is associated with increased oxidative stress that may give rise to the formation of lipid hydroperoxides (LOOH) and various secondary degradation products such as fragmented phosphatidylcholine (FPC) and lipids related to the platelet-activating factor (PAF). Because some oxidized phospholipids are potent proinflammatory agents, we measured the concentration of LOOH, FPC, and PAF-like activity in blood plasma of 36 patients who had undergone cardiac surgery and developed postoperative complications associated with systemic inflammatory response syndrome (SIRS) or multiple organ failure (MOF)...
July 2002: Shock
H Haupt
No abstract text is available yet for this article.
June 2000: Kinderkrankenschwester: Organ der Sektion Kinderkrankenpflege
D L Connolly, N A Haupt
No abstract text is available yet for this article.
May 17, 1999: Nursing Spectrum
J Rudolf, M Würker, M Neveling, M Grond, W F Haupt, W D Heiss
BACKGROUND: Clinical signs of hypokalemia are not directly related to the extent of the electrolyte imbalance, and therefore monosymptomatic cases may be observed. CASE REPORT: Following an acute gastroenteritis with considerable diarrhea, a 47-year-old male patient was admitted to hospital for progressive painful paraparesis. Upon admission, the patient complained of painful paresthesias in both legs, and a moderate flaccid paraparesis with widespread fasciculations and loss of leg tendon reflexes was found...
July 15, 1999: Medizinische Klinik
F Schellhammer, W Heindel, W F Haupt, P Landwehr, K Lackner
The aim of this study was to evaluate somatosensory evoked potentials (SEP) as a simple neurophysiological monitoring method in supra-aortal balloon test occlusions (BTO). The 13 patients examined had carcinoma of the larynx (n = 6), nasopharyngeal malignancy (n = 3), sphenoid meningioma (n = 2), mycotic aneurysm (n = 1), and a tumor of the carotid body (n = 1). Transfemoral balloon occlusion of the internal carotid artery was maintained for 30 min and monitored both clinically and by SEP. None of the 13 patients showed neurological deficits or pathological changes in the SEP...
1998: European Radiology
M Schlame, A B Schmid, R Haupt, B Rüstow, W J Kox
After operations with cardiopulmonary bypass, patients often show early symptoms of the systemic inflammatory response syndrome (SIRS). Potential mediators of SIRS include the platelet-activating factor (PAF), which has been linked to septic shock and multiple organ dysfunction. We studied the effect of cardiac surgery on PAF acetylhydrolase, the PAF-degrading plasma enzyme, as well as the relationship between the enzyme and the postoperative state of the patients. PAF acetylhydrolase activity decreased by 38+/-8% after instituting cardiopulmonary bypass because of plasma dilution and returned to near-preoperative levels within 6 h postsurgery...
May 1998: Shock
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