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H Haupt

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https://www.readbyqxmd.com/read/29700477/lower-extremity-outcome-measures-considerations-for-clinical-trials-in-spinal-cord-injury
#1
REVIEW
Marc Bolliger, Andrew R Blight, Edelle C Field-Fote, Kristin Musselman, Serge Rossignol, Dorothy Barthélemy, Laurent Bouyer, Milos R Popovic, Jan M Schwab, Michael L Boninger, Keith E Tansey, Giorgio Scivoletto, Naomi Kleitman, Linda A T Jones, Dany H Gagnon, Sylvie Nadeau, Dirk Haupt, Lea Awai, Chris S Easthope, Björn Zörner, Ruediger Rupp, Dan Lammertse, Armin Curt, John Steeves
STUDY DESIGN: This is a focused review article. OBJECTIVES: To identify important concepts in lower extremity (LE) assessment with a focus on locomotor outcomes and provide guidance on how existing outcome measurement tools may be best used to assess experimental therapies in spinal cord injury (SCI). The emphasis lies on LE outcomes in individuals with complete and incomplete SCI in Phase II-III trials. METHODS: This review includes a summary of topics discussed during a workshop focusing on LE function in SCI, conceptual discussion of corresponding outcome measures and additional focused literature review...
April 27, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29671086/the-nrp1-migraine-risk-variant-shows-evidence-of-association-with-menstrual-migraine
#2
Charmaine E Pollock, Heidi G Sutherland, Bridget H Maher, Rodney A Lea, Larisa M Haupt, Alison Frith, E Anne MacGregor, Lyn R Griffiths
BACKGROUND: In 2016, a large meta-analysis brought the number of susceptibility loci for migraine to 38. While sub-type analysis for migraine without aura (MO) and migraine with aura (MA) found some loci showed specificity to MO, the study did not test the loci with respect to other subtypes of migraine. This study aimed to test the hypothesis that single nucleotide polymorphisms (SNPs) robustly associated with migraine are individually or collectively associated with menstrual migraine (MM)...
April 18, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29663021/-willingness-to-participate-in-group-beneficial-dementia-research
#3
M Haupt, M Jänner
BACKGROUND: With the fourth Act on the amendment of pharmaceutical legal and other regulations it became law in Germany from the beginning of 2017 that under certain conditions, pharmaceutical research will be allowed with persons incapable of giving consent, even if this research may only be beneficial to other sufferers of the same disease, i. e. group beneficial research. OBJECTIVE: We conducted a semistructured, non-representative survey among psychiatric patients and their relatives...
April 16, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29391054/supar-is-associated-with-risk-of-future-acute-surgery-and-post-operative-mortality-in-acutely-admitted-medical-patients
#4
Jeppe Meyer, Morten Alstrup, Line J H Rasmussen, Martin Schultz, Steen Ladelund, Thomas H Haupt, Jens Tingleff, Kasper Iversen, Jesper Eugen-Olsen
BACKGROUND: Acutely admitted medical patients are often fragile and in risk of future surgery. The biomarker soluble urokinase plasminogen activator receptor (suPAR) is a predictor of readmission and mortality in the acute care setting. We aimed to investigate if suPAR also predicts acute surgery, which is associated with higher mortality than elective surgery, and if it predicts post-operative mortality. METHODS: A retrospective registry-based cohort study of 17,312 patients admitted to an acute medical unit in Denmark, from 18 November 2013 until 30 September 2015...
February 1, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28966548/genome-wide-linkage-and-association-analysis-of-primary-open-angle-glaucoma-endophenotypes-in-the-norfolk-island-isolate
#5
Elizabeth Matovinovic, Pik Fang Kho, Rodney A Lea, Miles C Benton, David A Eccles, Larisa M Haupt, Alex W Hewitt, Justin C Sherwin, David A Mackey, Lyn R Griffiths
PURPOSE: Primary open-angle glaucoma (POAG) refers to a group of heterogeneous diseases involving optic nerve damage. Two well-established risk factors for POAG are elevated intraocular pressure (IOP) and a thinner central corneal thickness (CCT). These endophenotypes exhibit a high degree of heritability across populations. Large-scale genome-wide association studies (GWASs) of outbred populations have robustly implicated several susceptibility gene variants for both IOP and CCT. Despite this progress, a substantial amount of genetic variance remains unexplained...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28886907/final-efficacy-immunogenicity-and-safety-analyses-of-a-nine-valent-human-papillomavirus-vaccine-in-women-aged-16-26-years-a-randomised-double-blind-trial
#6
Warner K Huh, Elmar A Joura, Anna R Giuliano, Ole-Erik Iversen, Rosires Pereira de Andrade, Kevin A Ault, Deborah Bartholomew, Ramon M Cestero, Edison N Fedrizzi, Angelica L Hirschberg, Marie-Hélène Mayrand, Angela Maria Ruiz-Sternberg, Jack T Stapleton, Dorothy J Wiley, Alex Ferenczy, Robert Kurman, Brigitte M Ronnett, Mark H Stoler, Jack Cuzick, Suzanne M Garland, Susanne K Kjaer, Oliver M Bautista, Richard Haupt, Erin Moeller, Michael Ritter, Christine C Roberts, Christine Shields, Alain Luxembourg
BACKGROUND: Primary analyses of a study in young women aged 16-26 years showed efficacy of the nine-valent human papillomavirus (9vHPV; HPV 6, 11, 16, 18, 31, 33, 45, 52, and 58) vaccine against infections and disease related to HPV 31, 33, 45, 52, and 58, and non-inferior HPV 6, 11, 16, and 18 antibody responses when compared with quadrivalent HPV (qHPV; HPV 6, 11, 16, and 18) vaccine. We aimed to report efficacy of the 9vHPV vaccine for up to 6 years following first administration and antibody responses over 5 years...
November 11, 2017: Lancet
https://www.readbyqxmd.com/read/28857192/moisture-content-of-root-canal-dentine-affects-detection-of-microcracks-using-micro-computed-tomography
#7
T Rödig, C Müller, M Hoch, F Haupt, X Schulz, A Wiegand, M Rizk
AIM: To evaluate the effect of moisture content in root canal dentine on detection of microcracks using micro-computed tomography. METHODOLOGY: Ten roots with and without craze lines or cracks (each n = 5) were selected and scanned six times with different moisture conditions of root dentine using a micro-CT scanner at a high resolution of 10.5 μm. Scanning conditions were as follows: (i) after 30-day wet storage, (ii) after 2-h dry time, (iii) after 48-h wet storage, (iv) after 24-h dry time, (v) after 48-h wet storage, (vi) after 2-h dry time...
March 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/28831512/-advance-directive-of-probands-in-pharmaceutical-research-a-medical-ethics-discussion
#8
REVIEW
M Haupt, F Jessen, H Fangerau
In the fourth Act on the amendment of pharmaceutical legal and other regulations in November 2016, the legislature has designated the proband advance directive based on the instrument of patient advance directive to enable group beneficial research with persons not capable of giving consent. This article describes the existing conditional need for group beneficial research and presents the problem of the decisive instrument for advance directives at the center of the considerations. The features of the proband advance directive concluded by the legislature stand in opposition to a successful implementation, particularly due to the necessary concrete clarification content far in advance for informed research participants...
March 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/28560240/mesoscale-brain-explorer-a-flexible-python-based-image-analysis-and-visualization-tool
#9
Dirk Haupt, Matthieu P Vanni, Federico Bolanos, Catalin Mitelut, Jeffrey M LeDue, Tim H Murphy
Imaging of mesoscale brain activity is used to map interactions between brain regions. This work has benefited from the pioneering studies of Grinvald et al., who employed optical methods to image brain function by exploiting the properties of intrinsic optical signals and small molecule voltage-sensitive dyes. Mesoscale interareal brain imaging techniques have been advanced by cell targeted and selective recombinant indicators of neuronal activity. Spontaneous resting state activity is often collected during mesoscale imaging to provide the basis for mapping of connectivity relationships using correlation...
July 2017: Neurophotonics
https://www.readbyqxmd.com/read/28559802/a-creb1-gene-polymorphism-rs2253206-is-associated-with-prospective-memory-in-a-healthy-cohort
#10
Nesli Avgan, Heidi G Sutherland, Rodney A Lea, Lauren K Spriggens, Larisa M Haupt, David H K Shum, Lyn R Griffiths
Prospective memory (PM) is generally defined as remembering to perform intended actions in the future and is important for functioning in daily life. Cyclic adenosine monophosphate (cAMP) responsive element binding protein 1 (CREB1) plays an important role in cognitive functions. In this study, we hypothesized that genetic variation in the CREB1 gene is associated with PM. We genotyped a CREB1 promoter polymorphism rs2253206 and tested it for association with PM in 619 healthy subjects. PM performance was measured using the Prospective and Retrospective Memory Questionnaire (PRMQ), the Comprehensive Assessment of Prospective Memory (CAPM), and the Memory for Intentions Screening Test (MIST)...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28386569/corrigendum-to-large-gliadin-peptides-detected-in-the-pancreas-of-nod-and-healthy-mice-following-oral-administration
#11
Susanne W Bruun, Knud Josefsen, Julia T Tanassi, Aleš Marek, Martin H F Pedersen, Ulrik Sidenius, Martin Haupt-Jorgensen, Julie C Antvorskov, Jesper Larsen, Niels H Heegaard, Karsten Buschard
[This corrects the article DOI: 10.1155/2016/2424306.].
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28304362/bdnf-variants-may-modulate-long-term-visual-memory-performance-in-a-healthy-cohort
#12
Nesli Avgan, Heidi G Sutherland, Lauren K Spriggens, Chieh Yu, Omar Ibrahim, Claire Bellis, Larisa M Haupt, David H K Shum, Lyn R Griffiths
Brain-derived neurotrophic factor (BDNF) is involved in numerous cognitive functions including learning and memory. BDNF plays an important role in synaptic plasticity in humans and rats with BDNF shown to be essential for the formation of long-term memories. We previously identified a significant association between the BDNF Val66Met polymorphism (rs6265) and long-term visual memory (p-value = 0.003) in a small cohort (n = 181) comprised of healthy individuals who had been phenotyped for various aspects of memory function...
March 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27857289/use-of-photoacoustic-excitation-and-laser-vibrometry-to-remotely-detect-trace-explosives
#13
C M Wynn, R W Haupt, J H Doherty, R R Kunz, W Bai, G Diebold
In this paper, we examine a laser-based approach to remotely initiate, measure, and differentiate acoustic and vibrational emissions from trace quantities of explosive materials against their environment. Using a pulsed ultraviolet laser (266 nm), we induce a significant (>100  Pa) photoacoustic response from small quantities of military-grade explosives. The photoacoustic signal, with frequencies predominantly between 100 and 500 kHz, is detected remotely via a wideband laser Doppler vibrometer. This two-laser system can be used to rapidly detect and discriminate explosives from ordinary background materials, which have significantly weaker photoacoustic response...
November 10, 2016: Applied Optics
https://www.readbyqxmd.com/read/27795959/large-gliadin-peptides-detected-in-the-pancreas-of-nod-and-healthy-mice-following-oral-administration
#14
Susanne W Bruun, Knud Josefsen, Julia T Tanassi, Aleš Marek, Martin H F Pedersen, Ulrik Sidenius, Martin Haupt-Jorgensen, Julie C Antvorskov, Jesper Larsen, Niels H Heegaard, Karsten Buschard
Gluten promotes type 1 diabetes in nonobese diabetic (NOD) mice and likely also in humans. In NOD mice and in non-diabetes-prone mice, it induces inflammation in the pancreatic lymph nodes, suggesting that gluten can initiate inflammation locally. Further, gliadin fragments stimulate insulin secretion from beta cells directly. We hypothesized that gluten fragments may cross the intestinal barrier to be distributed to organs other than the gut. If present in pancreas, gliadin could interact directly with the immune system and the beta cells to initiate diabetes development...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27723228/basal-insulin-peglispro-overview-of-a-novel-long-acting-insulin-with-reduced-peripheral-effect-resulting-in-a-hepato-preferential-action
#15
REVIEW
S J Jacober, M J Prince, J M Beals, M L Hartman, Y Qu, H Linnebjerg, P Garhyan, A Haupt
Basal insulin peglispro (BIL) is a novel basal insulin with a flat, prolonged activity profile. BIL has been demonstrated in a dog model, in healthy men and in patients with type 1 diabetes (T1D) to have significant hepato-preferential action resulting from reduced peripheral activity. In the IMAGINE-Phase 3 clinical trial program, more than 6000 patients were included, of whom ~3900 received BIL. Of the 7 pivotal IMAGINE trials, 3 studies were double-blinded and 3 were in T1D patients. BIL consistently demonstrated a greater HbA1c reduction, less glycaemic variability and a clinically relevant reduction in the rates of nocturnal hypoglycaemia across comparator [glargine and isophane insulin (NPH)] studies...
October 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27643694/late-cardiac-events-after-childhood-cancer-methodological-aspects-of-the-pan-european-study-pancaresurfup
#16
Elizabeth A M Feijen, Anna Font-Gonzalez, Elvira C van Dalen, Helena J H van der Pal, Raoul C Reulen, David L Winter, Claudia E Kuehni, Riccardo Haupt, Daniela Alessi, Julianne Byrne, Edit Bardi, Zsuzsanna Jakab, Desiree Grabow, Stanislaw Garwicz, Momcilo Jankovic, Gill A Levitt, Roderick Skinner, Lorna Zadravec Zaletel, Lars Hjorth, Wim J E Tissing, Florent de Vathaire, Mike M Hawkins, Leontien C M Kremer
BACKGROUND AND AIM: Childhood cancer survivors are at high risk of long-term adverse effects of cancer and its treatment, including cardiac events. The pan-European PanCareSurFup study determined the incidence and risk factors for cardiac events among childhood cancer survivors. The aim of this article is to describe the methodology of the cardiac cohort and nested case-control study within PanCareSurFup. METHODS: Eight data providers in Europe participating in PanCareSurFup identified and validated symptomatic cardiac events in their cohorts of childhood cancer survivors...
2016: PloS One
https://www.readbyqxmd.com/read/27633439/outcome-comorbidity-hospitalization-and-30-day-mortality-after-closure-of-acute-perforations-and-postoperative-anastomotic-leaks-by-the-over-the-scope-clip-otsc-in-an-unselected-cohort-of-patients
#17
MULTICENTER STUDY
M Raithel, H Albrecht, W Scheppach, M Farnbacher, W Haupt, A F Hagel, V Schellerer, F Vitali, M F Neurath, H T Schneider
BACKGROUND: Acute gastrointestinal (GI) wall defects contain a high risk of morbidity and mortality and may be closed endoscopically by a full-thickness over-the-scope clip (OTSC). METHODS: Unselected consecutive patients presenting with acute non-surgical perforations or postoperative anastomotic leaks or perforations underwent attempted OTSC placement as primary closure method after interdisciplinary consensus in three tertiary referral centres. Their clinical data and intervention characteristics were evaluated in an intention to treat analysis during a 24-month period to assess closure rates, 30-day mortality, hospitalization and comorbidity...
June 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/27621269/tdp-43-loss-of-function-inhibits-endosomal-trafficking-and-alters-trophic-signaling-in-neurons
#18
Benjamin M Schwenk, Hannelore Hartmann, Alperen Serdaroglu, Martin H Schludi, Daniel Hornburg, Felix Meissner, Denise Orozco, Alessio Colombo, Sabina Tahirovic, Meike Michaelsen, Franziska Schreiber, Simone Haupt, Michael Peitz, Oliver Brüstle, Clemens Küpper, Thomas Klopstock, Markus Otto, Albert C Ludolph, Thomas Arzberger, Peer-Hendrik Kuhn, Dieter Edbauer
Nuclear clearance of TDP-43 into cytoplasmic aggregates is a key driver of neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), but the mechanisms are unclear. Here, we show that TDP-43 knockdown specifically reduces the number and motility of RAB11-positive recycling endosomes in dendrites, while TDP-43 overexpression has the opposite effect. This is associated with delayed transferrin recycling in TDP-43-knockdown neurons and decreased β2-transferrin levels in patient CSF Whole proteome quantification identified the upregulation of the ESCRT component VPS4B upon TDP-43 knockdown in neurons...
November 2, 2016: EMBO Journal
https://www.readbyqxmd.com/read/27515131/the-chemical-class-of-quinazoline-compounds-provides-a-core-structure-for-the-design-of-anticytomegaloviral-kinase-inhibitors
#19
C Hutterer, S Hamilton, M Steingruber, I Zeitträger, H Bahsi, N Thuma, Z Naing, Z Örfi, L Örfi, E Socher, H Sticht, W Rawlinson, S Chou, V J Haupt, M Marschall
HCMV is a member of the family Herpesviridae and represents a worldwide distributed pathogen with seropositivity rates in the adult population ranging between 40% and 90%. Notably, HCMV infection is a serious, sometimes life-threatening medical problem for newborns and immunosuppressed individuals, including transplant recipients and patients under antitumoral chemotherapy. Current standard therapy with valganciclovir has the disadvantage of inducing drug-resistant virus mutants and toxicity-related side effects...
October 2016: Antiviral Research
https://www.readbyqxmd.com/read/27458300/recommendations-for-premature-ovarian-insufficiency-surveillance-for-female-survivors-of-childhood-adolescent-and-young-adult-cancer-a-report-from-the-international-late-effects-of-childhood-cancer-guideline-harmonization-group-in-collaboration-with-the-pancaresurfup
#20
REVIEW
Wendy van Dorp, Renée L Mulder, Leontien C M Kremer, Melissa M Hudson, Marry M van den Heuvel-Eibrink, Marleen H van den Berg, Jennifer M Levine, Eline van Dulmen-den Broeder, Natascia di Iorgi, Assunta Albanese, Saro H Armenian, Smita Bhatia, Louis S Constine, Andreas Corrias, Rebecca Deans, Uta Dirksen, Clarisa R Gracia, Lars Hjorth, Leah Kroon, Cornelis B Lambalk, Wendy Landier, Gill Levitt, Alison Leiper, Lillian Meacham, Alesandro Mussa, Sebastian J Neggers, Kevin C Oeffinger, Alberto Revelli, Hanneke M van Santen, Roderick Skinner, Andrew Toogood, William H Wallace, Riccardo Haupt
PURPOSE: Female survivors of childhood, adolescent, and young adult (CAYA) cancer who were treated with alkylating agents and/or radiation, with potential exposure of the ovaries, have an increased risk of premature ovarian insufficiency (POI). Clinical practice guidelines can facilitate these survivors' access to optimal treatment of late effects that may improve health and quality of survival; however, surveillance recommendations vary among the existing long-term follow-up guidelines, which impedes the implementation of screening...
October 1, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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