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https://www.readbyqxmd.com/read/28560240/mesoscale-brain-explorer-a-flexible-python-based-image-analysis-and-visualization-tool
#1
Dirk Haupt, Matthieu P Vanni, Federico Bolanos, Catalin Mitelut, Jeffrey M LeDue, Tim H Murphy
Imaging of mesoscale brain activity is used to map interactions between brain regions. This work has benefited from the pioneering studies of Grinvald et al., who employed optical methods to image brain function by exploiting the properties of intrinsic optical signals and small molecule voltage-sensitive dyes. Mesoscale interareal brain imaging techniques have been advanced by cell targeted and selective recombinant indicators of neuronal activity. Spontaneous resting state activity is often collected during mesoscale imaging to provide the basis for mapping of connectivity relationships using correlation...
July 2017: Neurophotonics
https://www.readbyqxmd.com/read/28559802/a-creb1-gene-polymorphism-rs2253206-is-associated-with-prospective-memory-in-a-healthy-cohort
#2
Nesli Avgan, Heidi G Sutherland, Rodney A Lea, Lauren K Spriggens, Larisa M Haupt, David H K Shum, Lyn R Griffiths
Prospective memory (PM) is generally defined as remembering to perform intended actions in the future and is important for functioning in daily life. Cyclic adenosine monophosphate (cAMP) responsive element binding protein 1 (CREB1) plays an important role in cognitive functions. In this study, we hypothesized that genetic variation in the CREB1 gene is associated with PM. We genotyped a CREB1 promoter polymorphism rs2253206 and tested it for association with PM in 619 healthy subjects. PM performance was measured using the Prospective and Retrospective Memory Questionnaire (PRMQ), the Comprehensive Assessment of Prospective Memory (CAPM), and the Memory for Intentions Screening Test (MIST)...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28386569/corrigendum-to-large-gliadin-peptides-detected-in-the-pancreas-of-nod-and-healthy-mice-following-oral-administration
#3
Susanne W Bruun, Knud Josefsen, Julia T Tanassi, Aleš Marek, Martin H F Pedersen, Ulrik Sidenius, Martin Haupt-Jorgensen, Julie C Antvorskov, Jesper Larsen, Niels H Heegaard, Karsten Buschard
[This corrects the article DOI: 10.1155/2016/2424306.].
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28304362/bdnf-variants-may-modulate-long-term-visual-memory-performance-in-a-healthy-cohort
#4
Nesli Avgan, Heidi G Sutherland, Lauren K Spriggens, Chieh Yu, Omar Ibrahim, Claire Bellis, Larisa M Haupt, David H K Shum, Lyn R Griffiths
Brain-derived neurotrophic factor (BDNF) is involved in numerous cognitive functions including learning and memory. BDNF plays an important role in synaptic plasticity in humans and rats with BDNF shown to be essential for the formation of long-term memories. We previously identified a significant association between the BDNF Val66Met polymorphism (rs6265) and long-term visual memory (p-value = 0.003) in a small cohort (n = 181) comprised of healthy individuals who had been phenotyped for various aspects of memory function...
March 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27857289/use-of-photoacoustic-excitation-and-laser-vibrometry-to-remotely-detect-trace-explosives
#5
C M Wynn, R W Haupt, J H Doherty, R R Kunz, W Bai, G Diebold
In this paper, we examine a laser-based approach to remotely initiate, measure, and differentiate acoustic and vibrational emissions from trace quantities of explosive materials against their environment. Using a pulsed ultraviolet laser (266 nm), we induce a significant (>100  Pa) photoacoustic response from small quantities of military-grade explosives. The photoacoustic signal, with frequencies predominantly between 100 and 500 kHz, is detected remotely via a wideband laser Doppler vibrometer. This two-laser system can be used to rapidly detect and discriminate explosives from ordinary background materials, which have significantly weaker photoacoustic response...
November 10, 2016: Applied Optics
https://www.readbyqxmd.com/read/27795959/large-gliadin-peptides-detected-in-the-pancreas-of-nod-and-healthy-mice-following-oral-administration
#6
Susanne W Bruun, Knud Josefsen, Julia T Tanassi, Aleš Marek, Martin H F Pedersen, Ulrik Sidenius, Martin Haupt-Jorgensen, Julie C Antvorskov, Jesper Larsen, Niels H Heegaard, Karsten Buschard
Gluten promotes type 1 diabetes in nonobese diabetic (NOD) mice and likely also in humans. In NOD mice and in non-diabetes-prone mice, it induces inflammation in the pancreatic lymph nodes, suggesting that gluten can initiate inflammation locally. Further, gliadin fragments stimulate insulin secretion from beta cells directly. We hypothesized that gluten fragments may cross the intestinal barrier to be distributed to organs other than the gut. If present in pancreas, gliadin could interact directly with the immune system and the beta cells to initiate diabetes development...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27723228/basal-insulin-peglispro-overview-of-a-novel-long-acting-insulin-with-reduced-peripheral-effect-resulting-in-a-hepato-preferential-action
#7
S J Jacober, M J Prince, J M Beals, M L Hartman, Y Qu, H Linnebjerg, P Garhyan, A Haupt
Basal insulin peglispro (BIL) is a novel basal insulin with a flat, prolonged activity profile. BIL has been demonstrated in a dog model, in healthy men and in patients with type 1 diabetes (T1D) to have significant hepato-preferential action resulting from reduced peripheral activity. In the IMAGINE-Phase 3 clinical trial program, more than 6000 patients were included, of whom ~3900 received BIL. Of the 7 pivotal IMAGINE trials, 3 studies were double-blinded and 3 were in T1D patients. BIL consistently demonstrated a greater HbA1c reduction, less glycaemic variability and a clinically relevant reduction in the rates of nocturnal hypoglycaemia across comparator [glargine and isophane insulin (NPH)] studies...
October 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27643694/late-cardiac-events-after-childhood-cancer-methodological-aspects-of-the-pan-european-study-pancaresurfup
#8
Elizabeth A M Feijen, Anna Font-Gonzalez, Elvira C van Dalen, Helena J H van der Pal, Raoul C Reulen, David L Winter, Claudia E Kuehni, Riccardo Haupt, Daniela Alessi, Julianne Byrne, Edit Bardi, Zsuzsanna Jakab, Desiree Grabow, Stanislaw Garwicz, Momcilo Jankovic, Gill A Levitt, Roderick Skinner, Lorna Zadravec Zaletel, Lars Hjorth, Wim J E Tissing, Florent de Vathaire, Mike M Hawkins, Leontien C M Kremer
BACKGROUND AND AIM: Childhood cancer survivors are at high risk of long-term adverse effects of cancer and its treatment, including cardiac events. The pan-European PanCareSurFup study determined the incidence and risk factors for cardiac events among childhood cancer survivors. The aim of this article is to describe the methodology of the cardiac cohort and nested case-control study within PanCareSurFup. METHODS: Eight data providers in Europe participating in PanCareSurFup identified and validated symptomatic cardiac events in their cohorts of childhood cancer survivors...
2016: PloS One
https://www.readbyqxmd.com/read/27633439/outcome-comorbidity-hospitalization-and-30-day-mortality-after-closure-of-acute-perforations-and-postoperative-anastomotic-leaks-by-the-over-the-scope-clip-otsc-in-an-unselected-cohort-of-patients
#9
M Raithel, H Albrecht, W Scheppach, M Farnbacher, W Haupt, A F Hagel, V Schellerer, F Vitali, M F Neurath, H T Schneider
BACKGROUND: Acute gastrointestinal (GI) wall defects contain a high risk of morbidity and mortality and may be closed endoscopically by a full-thickness over-the-scope clip (OTSC). METHODS: Unselected consecutive patients presenting with acute non-surgical perforations or postoperative anastomotic leaks or perforations underwent attempted OTSC placement as primary closure method after interdisciplinary consensus in three tertiary referral centres. Their clinical data and intervention characteristics were evaluated in an intention to treat analysis during a 24-month period to assess closure rates, 30-day mortality, hospitalization and comorbidity...
June 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/27621269/tdp-43-loss-of-function-inhibits-endosomal-trafficking-and-alters-trophic-signaling-in-neurons
#10
Benjamin M Schwenk, Hannelore Hartmann, Alperen Serdaroglu, Martin H Schludi, Daniel Hornburg, Felix Meissner, Denise Orozco, Alessio Colombo, Sabina Tahirovic, Meike Michaelsen, Franziska Schreiber, Simone Haupt, Michael Peitz, Oliver Brüstle, Clemens Küpper, Thomas Klopstock, Markus Otto, Albert C Ludolph, Thomas Arzberger, Peer-Hendrik Kuhn, Dieter Edbauer
Nuclear clearance of TDP-43 into cytoplasmic aggregates is a key driver of neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), but the mechanisms are unclear. Here, we show that TDP-43 knockdown specifically reduces the number and motility of RAB11-positive recycling endosomes in dendrites, while TDP-43 overexpression has the opposite effect. This is associated with delayed transferrin recycling in TDP-43-knockdown neurons and decreased β2-transferrin levels in patient CSF Whole proteome quantification identified the upregulation of the ESCRT component VPS4B upon TDP-43 knockdown in neurons...
November 2, 2016: EMBO Journal
https://www.readbyqxmd.com/read/27515131/the-chemical-class-of-quinazoline-compounds-provides-a-core-structure-for-the-design-of-anticytomegaloviral-kinase-inhibitors
#11
C Hutterer, S Hamilton, M Steingruber, I Zeitträger, H Bahsi, N Thuma, Z Naing, Z Örfi, L Örfi, E Socher, H Sticht, W Rawlinson, S Chou, V J Haupt, M Marschall
HCMV is a member of the family Herpesviridae and represents a worldwide distributed pathogen with seropositivity rates in the adult population ranging between 40% and 90%. Notably, HCMV infection is a serious, sometimes life-threatening medical problem for newborns and immunosuppressed individuals, including transplant recipients and patients under antitumoral chemotherapy. Current standard therapy with valganciclovir has the disadvantage of inducing drug-resistant virus mutants and toxicity-related side effects...
October 2016: Antiviral Research
https://www.readbyqxmd.com/read/27458300/recommendations-for-premature-ovarian-insufficiency-surveillance-for-female-survivors-of-childhood-adolescent-and-young-adult-cancer-a-report-from-the-international-late-effects-of-childhood-cancer-guideline-harmonization-group-in-collaboration-with-the-pancaresurfup
#12
REVIEW
Wendy van Dorp, Renée L Mulder, Leontien C M Kremer, Melissa M Hudson, Marry M van den Heuvel-Eibrink, Marleen H van den Berg, Jennifer M Levine, Eline van Dulmen-den Broeder, Natascia di Iorgi, Assunta Albanese, Saro H Armenian, Smita Bhatia, Louis S Constine, Andreas Corrias, Rebecca Deans, Uta Dirksen, Clarisa R Gracia, Lars Hjorth, Leah Kroon, Cornelis B Lambalk, Wendy Landier, Gill Levitt, Alison Leiper, Lillian Meacham, Alesandro Mussa, Sebastian J Neggers, Kevin C Oeffinger, Alberto Revelli, Hanneke M van Santen, Roderick Skinner, Andrew Toogood, William H Wallace, Riccardo Haupt
PURPOSE: Female survivors of childhood, adolescent, and young adult (CAYA) cancer who were treated with alkylating agents and/or radiation, with potential exposure of the ovaries, have an increased risk of premature ovarian insufficiency (POI). Clinical practice guidelines can facilitate these survivors' access to optimal treatment of late effects that may improve health and quality of survival; however, surveillance recommendations vary among the existing long-term follow-up guidelines, which impedes the implementation of screening...
October 1, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27417288/low-dose-growth-hormone-therapy-reduces-inflammation-in-hiv-infected-patients-a-randomized-placebo-controlled-study
#13
RANDOMIZED CONTROLLED TRIAL
Johanne Bjerre Lindboe, Anne Langkilde, Jesper Eugen-Olsen, Birgitte R Hansen, Thomas H Haupt, Janne Petersen, Ove Andersen
BACKGROUND: Combination antiretroviral therapy (cART) has drastically increased the life expectancy of HIV-infected patients. However, HIV-infected patients exhibit increased inflammation and 33-58% exhibit a characteristic fat re-distribution termed HIV-associated lipodystrophy syndrome (HALS). Recombinant human growth hormone (rhGH) has been tested as treatment of HALS. Low-dose rhGH therapy improves thymopoiesis and fat distribution in HIV-infected patients and appears to be well tolerated...
November 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27291514/high-throughput-automated-home-cage-mesoscopic-functional-imaging-of-mouse-cortex
#14
Timothy H Murphy, Jamie D Boyd, Federico Bolaños, Matthieu P Vanni, Gergely Silasi, Dirk Haupt, Jeff M LeDue
Mouse head-fixed behaviour coupled with functional imaging has become a powerful technique in rodent systems neuroscience. However, training mice can be time consuming and is potentially stressful for animals. Here we report a fully automated, open source, self-initiated head-fixation system for mesoscopic functional imaging in mice. The system supports five mice at a time and requires minimal investigator intervention. Using genetically encoded calcium indicator transgenic mice, we longitudinally monitor cortical functional connectivity up to 24 h per day in >7,000 self-initiated and unsupervised imaging sessions up to 90 days...
2016: Nature Communications
https://www.readbyqxmd.com/read/26476291/association-of-the-microrna-single-nucleotide-polymorphism-rs2910164-in-mir146a-with-sporadic-breast-cancer-susceptibility-a-case-control-study
#15
Akanksha Upadhyaya, Robert A Smith, Diego Chacon-Cortes, Gwladys Revêchon, Claire Bellis, Rod A Lea, Larisa M Haupt, Suzanne K Chambers, Philippa H Youl, Lyn R Griffiths
BACKGROUND: Breast cancer (BC) is primarily considered a genetic disorder with a complex interplay of factors including age, gender, ethnicity, family history, personal history and lifestyle with associated hormonal and non-hormonal risk factors. The SNP rs2910164 in miR146a (a G to C polymorphism) was previously associated with increased risk of BC in cases with at least a single copy of the C allele in breast cancer, though results in other cancers and populations have shown significant variation...
January 15, 2016: Gene
https://www.readbyqxmd.com/read/26471359/wdr5-supports-an-n-myc-transcriptional-complex-that-drives-a-protumorigenic-gene-expression-signature-in-neuroblastoma
#16
Yuting Sun, Jessica L Bell, Daniel Carter, Samuele Gherardi, Rebecca C Poulos, Giorgio Milazzo, Jason W H Wong, Rima Al-Awar, Andrew E Tee, Pei Y Liu, Bing Liu, Bernard Atmadibrata, Matthew Wong, Toby Trahair, Quan Zhao, Jason M Shohet, Ygal Haupt, Johannes H Schulte, Peter J Brown, Cheryl H Arrowsmith, Masoud Vedadi, Karen L MacKenzie, Stefan Hüttelmaier, Giovanni Perini, Glenn M Marshall, Antony Braithwaite, Tao Liu
MYCN gene amplification in neuroblastoma drives a gene expression program that correlates strongly with aggressive disease. Mechanistically, trimethylation of histone H3 lysine 4 (H3K4) at target gene promoters is a strict prerequisite for this transcriptional program to be enacted. WDR5 is a histone H3K4 presenter that has been found to have an essential role in H3K4 trimethylation. For this reason, in this study, we investigated the relationship between WDR5-mediated H3K4 trimethylation and N-Myc transcriptional programs in neuroblastoma cells...
December 1, 2015: Cancer Research
https://www.readbyqxmd.com/read/26293552/antimicrobial-effect-and-biocompatibility-of-novel-metallic-nanocrystalline-implant-coatings
#17
Martin Gosau, Michael Haupt, Sibylle Thude, Martin Strowitzki, Boris Schminke, Ralf Buergers
AIM: The present in vitro study was designed to evaluate the surface characteristics, biocompatibilities and antimicrobial effects of experimental titanium implant surfaces, coated by nanocrystalline silver, copper, and bismuth. Biocompatible and antimicrobial implant modifications could result in reduced biofilm formation on implant surfaces and therefore in less periimplant inflammation. FINDINGS: Titanium discs (thickness 1 and 12 mm in diameter) were coated by pulsed magnetron-sputtering of nanocrystalline metals (bismuth, copper, and silver)...
August 21, 2015: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/26284258/strong-impact-of-smoking-on-multimorbidity-and-cardiovascular-risk-among-human-immunodeficiency-virus-infected-individuals-in-comparison-with-the-general-population
#18
Barbara Hasse, Philip E Tarr, Pedro Marques-Vidal, Gerard Waeber, Martin Preisig, Vincent Mooser, Fabio Valeri, Sima Djalali, Rauch Andri, Enos Bernasconi, Alexandra Calmy, Matthias Cavassini, Pietro Vernazza, Manuel Battegay, Rainer Weber, Oliver Senn, Peter Vollenweider, Bruno Ledergerber, V Aubert, J Barth, M Battegay, E Bernasconi, J Böni, H C Bucher, C Burton-Jeangros, A Calmy, M Cavassini, M Egger, L Elzi, J Fehr, J Fellay, H Furrer, C A Fux, M Gorgievski, H Günthard, D Haerry, B Hasse, H H Hirsch, I Hösli, C Kahlert, L Kaiser, O Keiser, T Klimkait, R Kouyos, H Kovari, B Ledergerber, G Martinetti, B Martinez de Tejada, K Metzner, N Müller, D Nadal, G Pantaleo, A Rauch, S Regenass, M Rickenbach, C Rudin, F Schöni-Affolter, P Schmid, D Schultze, J Schüpbach, R Speck, C Staehelin, P Tarr, A Telenti, A Trkola, P Vernazza, R Weber, S Yerly, Aubry Jean-Michel, Bochud Murielle, Gaspoz Jean Michel, Hock Christoph, Lüscher Thomas, Marques Vidal Pedro, Mooser Vincent, Paccaud Fred, Preisig Martin, Vollenweider Peter, Von Känel Roland, Vladeta Aidacic, Waeber Gerard, Beriger Jürg, Bertschi Markus, Bhend Heinz, Büchi Martin, Bürke Hans-Ulrich, Bugmann Ivo, Cadisch Reto, Charles Isabelle, Chmiel Corinne, Djalali Sima, Duner Peter, Erni Simone, Forster Andrea, Frei Markus, Frey Claudius, Frey Jakob, Gibreil Musa Ali, Günthard Matthias, Haller Denis, Hanselmann Marcel, Häuptli Walter, Heininger Simon, Huber Felix, Hufschmid Paul, Kaiser Eva, Kaplan Vladimir, Klaus Daniel, Koch Stephan, Köstner Beat, Kuster Benedict, Kuster Heidi, Ladan Vesna, Lauffer Giovanni, Leibundgut Hans Werner, Luchsinger Phillippe, Lüscher Severin, Maier Christoph, Martin Jürgen, Meli Damian, Messerli Werner, Morger Titus, Navarro Valentina, Rizzi Jakob, Rosemann Thomas, Sajdl Hana, Schindelek Frank, Schlatter Georg, Senn Oliver, Somaini Pietro, Staeger Jacques, Staehelin Alfred, Steinegger Alois, Steurer Claudia, Suter Othmar, Truong The Phuoc, Vecellio Marco, Violi Alessandro, Von Allmen René, Waeckerlin Hans, Weber Fritz, Weber-Schär Johanna, Widler Joseph, Zoller Marco
Background.  Although acquired immune deficiency syndrome-associated morbidity has diminished due to excellent viral control, multimorbidity may be increasing among human immunodeficiency virus (HIV)-infected persons compared with the general population. Methods.  We assessed the prevalence of comorbidities and multimorbidity in participants of the Swiss HIV Cohort Study (SHCS) compared with the population-based CoLaus study and the primary care-based FIRE (Family Medicine ICPC-Research using Electronic Medical Records) records...
September 2015: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/26187504/apr-246-potently-inhibits-tumour-growth-and-overcomes-chemoresistance-in-preclinical-models-of-oesophageal-adenocarcinoma
#19
David S H Liu, Matthew Read, Carleen Cullinane, Walid J Azar, Christina M Fennell, Karen G Montgomery, Sue Haupt, Ygal Haupt, Klas G Wiman, Cuong P Duong, Nicholas J Clemons, Wayne A Phillips
OBJECTIVES: p53 is a critical tumour suppressor and is mutated in 70% of oesophageal adenocarcinomas (OACs), resulting in chemoresistance and poor survival. APR-246 is a first-in-class reactivator of mutant p53 and is currently in clinical trials. In this study, we characterised the activity of APR-246 and its effect on p53 signalling in a large panel of cell line xenograft (CLX) and patient-derived xenograft (PDX) models of OAC. DESIGN: In vitro response to APR-246 was assessed using clonogenic survival, cell cycle and apoptosis assays...
October 2015: Gut
https://www.readbyqxmd.com/read/25984436/coma-and-cerebral-imaging
#20
Walter F Haupt, Hans Christian Hansen, Rudolf W C Janzen, Raimund Firsching, Norbert Galldiks
The clinical sign of coma is a common feature in critical care medicine. However, little information has been put forth on the correlations between coma and cerebral imaging methods. The purpose of the article is to compile the available information derived from various imaging methods and placing it in a context of clinical knowledge of coma and related states. The definition of coma and the cerebral structures responsible for consciousness are described; the mechanisms of cerebral lesions leading to impaired consciousness and coma are explained...
2015: SpringerPlus
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