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https://www.readbyqxmd.com/read/29154022/the-anti-tumor-effect-of-rankl-inhibition-in-malignant-solid-tumors-a-systematic-review
#1
REVIEW
A F de Groot, N M Appelman-Dijkstra, S H van der Burg, J R Kroep
At present, accumulating evidence suggests that inhibition of receptor activator of nuclear factor kappa-B ligand (RANKL) does not only induce an increase in bone mass and strength, but also has anti-tumor effects. Denosumab, an antibody targeting RANKL, is used to treat osteoporosis and to prevent skeletal related events (SREs) in patients with bone metastases originating from solid tumors. However, expression of RANKL and its receptor activator of nuclear factor kappa-B (RANK) is not solely restricted to cells involved in homeostasis of the bone and RANKL-RANK signalling appears to play a substantial role in many other processes in the body like mammary physiology, mammary tumorigenesis and the immune system...
November 2, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29148830/age-differences-in-the-use-of-emotion-regulation-strategies-derived-from-the-process-model-of-emotion-regulation-a-systematic-review
#2
V C Allen, T D Windsor
OBJECTIVES: This review examines differences in the use of emotion regulation (ER) strategies among younger and older adults. METHOD: A systematic review using search terms related to ageing and ER identified 23 relevant studies. Narrative synthesis was adopted to analyse the findings. RESULTS: Generally, greater use of situation selection and attentional deployment was identified among older adults, although these relationships were dependent on contextual/moderator variables...
November 17, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29135378/same-sex-parenting-identification-of-social-representations-in-a-sample-of-portuguese-professionals
#3
Paula Xavier, Isabel Alberto, Francisco Mendes
Although international scientific research and the position of professional associations reiterate that the parents' sexual orientation is not a criterion of parenting quality, the social recognition of same-sex parenting remains difficult in Portugal. Given the importance of forensic issues in this field, this study aims to identify the representations of psychologists, social workers, lawyers/attorneys, and judges regarding same-sex parenting. The study involves five homogeneous focus groups with a total of 19 professionals...
November 14, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/29135364/mothers-neural-and-behavioral-responses-to-their-infants-distress-cues-the-role-of-secure-base-script-knowledge
#4
Ashley M Groh, Katherine C Haydon
This research examined mothers' secure base script knowledge-reflected in the ability to generate narratives in which attachment-relevant problems are recognized, competent help is offered, and problems are resolved-and its significance for early-stage processing of infants' distress cues, using event-related potentials in an emotion oddball task. Mothers with lower secure base script knowledge exhibited (a) a heightened P3b response-reflective of greater allocation of cognitive resources-to their infants' distressed (but not happy) target facial expressions; (b) a larger P3b response to their infants' distressed (compared with happy) target facial expressions, which is indicative of allocating disproportional attentional resources to processing their infants' distress; and (c) poorer accuracy in identifying their infants' distressed target facial expressions...
November 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/29134851/perceptions-and-uses-of-public-and-private-health-care-in-a-brazilian-favela
#5
Débora Castiglione, Gina S Lovasi, Marilia S Carvalho
Since 1988, Brazil has reorganized and expanded its public health care system, defining access to health care as a right of every citizen. In parallel, the private health care sector grew rapidly to become one of the largest in the world. We explore the use of public and private health care by a low-income population living in a favela, Rio das Pedras, in Rio de Janeiro. At the time of data collection, only part of the community was covered by the primary health care program. We conducted semistructured interviews with 14 adults, both with and without access to the public primary care program...
November 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/29132284/love-matters-exploring-conceptions-of-love-in-rwanda-and-swaziland-and-relationship-to-hiv-and-intimate-partner-violence
#6
Allison Ruark, Erin Stern, Thandeka Dlamini-Simelane, Marie Fidele Kakuze
Health risks such as intimate partner violence (IPV) and HIV infection often occur within intimate sexual relationships, yet the study of love and intimacy is largely absent from health research on African populations. This study explores how women and men in Rwanda and Swaziland understand and represent love in their intimate sexual partnerships. In Rwanda, 58 in-depth interviews with 15 couples, 12 interviews with activists, and 24 focus group discussions were carried out during formative and evaluative research of the Indashyikirwa programme, which aims to reduce IPV and support healthy couple relationships...
December 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/29132079/absence-of-delay-in-spontaneous-use-of-gestures-in-spoken-narratives-among-children-with-autism-spectrum-disorders
#7
Miranda Kit-Yi Wong, Wing-Chee So
BACKGROUND: Gestures are spontaneous hand movements produced when speaking. Despite gestures being of communicative significance, little is known about the gestural production in spoken narratives in six- to 12-year-old children with Autism Spectrum Disorders (ASD). AIMS: The present study examined whether six- to 12-year-old children with ASD have a delay in gestural production in a spoken narrative task, in comparison to their typically-developing (TD) peers. METHODS AND PROCEDURES: Six- to-12-year-old children with ASD (N=14) and their age- and IQ-matched TD peers (N=12) narrated a story, which could elicit spontaneous speech and gestures...
November 10, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29130425/communication-about-palliative-care-a-phenomenological-study-exploring-patient-views-and-responses-to-its-discussion
#8
Anna Collins, Sue-Anne McLachlan, Jennifer Philip
BACKGROUND: Communication about palliative care is a complex task frequently delayed until otherwise unavoidable. There is a need for discussion of palliative care to be viewed as a distinct communication task that is guided by empirical data. However, little is known of patient views and responses to these encounters. AIM: To explore patient views surrounding communication about palliative care and their responses to its discussion. DESIGN: Cross-sectional, prospective, exploratory qualitative design, involving narrative-style interviews and underpinned by an interpretative phenomenological framework...
October 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29125091/how-children-learn-to-produce-appropriate-referring-expressions-in-narratives-the-role-of-clarification-requests-and-modeling
#9
Ana M Carmiol, Danielle Matthews, Odir A Rodríguez-Villagra
Asking children to clarify themselves promotes their ability to uniquely identify objects in referential communication tasks. However, little is known about whether parents ask preschoolers for clarification during interactions and, if so, how. Study 1 explored how mothers clarify their preschoolers' ambiguous descriptions of the characters in their narratives, and whether clarification requests affect children's repairs of their ambiguous descriptions. Mothers were found to use different strategies, including signaling misunderstanding and modeling appropriate descriptions...
November 10, 2017: Journal of Child Language
https://www.readbyqxmd.com/read/29121859/alterations-in-pgc1%C3%AE-expression-levels-are-involved-in-colorectal-cancer-risk-a-qualitative-systematic-review
#10
Jéssica Alonso-Molero, Carmen González-Donquiles, Tania Fernández-Villa, Fernanda de Souza-Teixeira, Laura Vilorio-Marqués, Antonio J Molina, Vicente Martín
BACKGROUND: Colorectal cancer (CRC) is a major global public health problem and the second leading cause of cancer-related death. Mitochondrial dysfunction has long been suspected to be involved in this type of tumorigenesis, as supported by an accumulating body of research evidence. However, little is known about how mitochondrial alterations contribute to tumorigenesis. Mitochondrial biogenesis is a fundamental cellular process required to maintain functional mitochondria and as an adaptive mechanism in response to changing energy requirements...
November 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29105153/making-sense-of-antisense-oligonucleotides-a-narrative-review
#11
REVIEW
Neelam Goyal, Pushpa Narayanaswami
Synthetic nucleic acid sequences that bind to ribonucleic acid (RNA) through Watson-Crick base pairing are known as antisense oligonucleotides (ASOs) because they are complementary to "sense strand" nucleic acids. ASOs bind to selected sequences of RNA and regulate the expression of genes by several mechanisms depending on their chemical properties and targets. They can be used to restore deficient protein expression, reduce the expression of a toxic protein, modify functional effects of proteins or reduce toxicity of mutant proteins...
November 3, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29102557/textual-analysis-of-general-surgery-residency-personal-statements-topics-and-gender-differences
#12
Laura Ostapenko, Cheryl Schonhardt-Bailey, Jessica Walling Sublette, Douglas S Smink, Nora Y Osman
PURPOSE: Applicants to US general surgery residency training programs submit standardized applications. Applicants use the personal statement to express their individual rationale for a career in surgery. Our research explores common topics and gender differences within the personal statements of general surgery applicants. METHODS: We analyzed the electronic residency application service personal statements of 578 applicants (containing 3,82,405 words) from Liaison Committee on Medical Education-accredited medical schools to a single ACGME-accredited general surgery program using an automated textual analysis program to identify common topics and gender differences...
October 25, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29095126/experiencing-menopause-in-the-uk-the-interrelated-narratives-of-normality-distress-and-transformation
#13
Isabel de Salis, Amanda Owen-Smith, Jenny L Donovan, Debbie A Lawlor
We investigated the experience and perspectives of menopause among 48 UK mothers through qualitative in-depth interviews. Interviews were analyzed thematically then explored using social science theories. Three interdependent narratives emerged: menopause as a normal, biological process, distinct from self and social transitions; menopause as struggle, an "idiom of distress" expressing upset, identity loss, shame, and social upheaval; and menopause as transformative and liberating, arising from biopsychic and relational changes...
November 2, 2017: Journal of Women & Aging
https://www.readbyqxmd.com/read/29073185/exploring-the-perceptions-of-physicians-caregivers-and-families-towards-artificial-nutrition-and-hydration-for-people-in-permanent-vegetative-state-how-can-a-photo-elicitation-method-help
#14
Elodie Cretin, Lionel Pazart, Marie-Christine Rousseau, Alain Noé, Pierre Decavel, Aline Chassagne, Aurélie Godard-Marceau, Hélène Trimaille, Florence Mathieu-Nicot, Yvan Beaussant, Damien Gabriel, Serge Daneault, Régis Aubry
The question of withdrawing artificial nutrition and hydration from people in a permanent vegetative state sparks considerable ethical and legal debate. Therefore, understanding the elements that influence such a decision is crucial. However, exploring perceptions of artificial nutrition and hydration is methodologically challenging for several reasons. First, because of the emotional state of the professionals and family members, who are facing an extremely distressing situation; second, because this question mirrors representations linked to a deep-rooted fear of dying of hunger and thirst; and third, because of taboos surrounding death...
2017: PloS One
https://www.readbyqxmd.com/read/29072557/-gay-guys-are-shit-lovers-and-lesbians-are-obsessed-with-fingers-the-mis-representation-of-lgbtiq-people-in-thai-news-media
#15
Kangwan Fongkaew, Anoporn Khruataeng, Sumon Unsathit, Matawii Khamphiirathasana, Nisarat Jongwisan, Oranong Arlunaek, Jensen Byrne
This paper presents an analysis of news reports presenting information or opinions about Lesbian, Gay, Bisexual, Transgender Intersex and Queer (LGBTIQ) people taken from six Thai media outlets over a period of one year. The aim was to explore how LGBTIQ people are portrayed in news media narratives. LGBTIQ identities were found to be vastly underrepresented, and when represented were often represented inaccurately, stereotypically, harmfully or without a clear understanding of the diversity of sexual orientations, gender identities and gender expressions...
October 26, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/29065812/grant-writing-moving-from-generating-ideas-to-applying-to-grants-that-matter
#16
David Nelson, Leslie Ruffalo
There is an extraordinary burden placed upon the healthcare system and people as a result of health disparities that exist within the United States. If there is going to be a concerted effort to develop innovative strategies to reduce health disparities, input from the community and behavioral scientists can and should be included in this approach and narrative. Grant writing provides one vehicle to express the narrative and to provide a means to fund research and programs within clinic-based and community settings...
May 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29059210/measures-of-cardiovascular-autonomic-activity-in-insomnia-disorder-a-systematic-review
#17
REVIEW
Marina-Marinela Nano, Pedro Fonseca, Rik Vullings, Ronald M Aarts
BACKGROUND: Insomnia disorder is a widespread sleep disorder with a prevalence of approximately 10%. Even though the link between insomnia and cardiovascular activity is not exactly clear, it is generally assumed that cardiovascular autonomic modifications could occur as a result of sleeplessness, or, alternatively, that autonomic alterations could be an expression of a hyper-arousal state. This review investigates whether cardiovascular measures are different between insomniacs and controls...
2017: PloS One
https://www.readbyqxmd.com/read/29056645/fertility-lost-fertility-found-narratives-from-the-leading-edge-of-oncofertility
#18
Teresa K Woodruff
A cancer diagnosis at a young age creates one of the most existential crises one can imagine. The good news is that for many of these young patients, they will survive their diagnosis. They will be told of the side effects of treatment including loss of hair but will not be told of the other losses associated with their reproductive function-loss of menstrual cycles, early menopause and the potential for pregnancy for women, loss of viable sperm for men, and loss of sexual libido in both cases. Not all cancer treatments result in the same series of fertility effects so one of the issues that physicians face is determining what the best course of fertility sparing options should be...
2017: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/29056609/adjunctive-avatar-therapy-for-mentalization-based-treatment-of-borderline-personality-disorder-a-mixed-methods-feasibility-study
#19
Caroline J Falconer, Penny Cutting, E Bethan Davies, Chris Hollis, Paul Stallard, Paul Moran
BACKGROUND: Borderline personality disorder (BPD) is characterised by severe instability in emotions, identity, relationships and impulsive behaviour. One contributing factor to BPD is deficient mentalizing-our ability to understand the mental states of others and ourselves. Psychotherapies can be effective at reducing symptoms of BPD but effects are small. Innovative ways of enhancing existing therapies are therefore essential. OBJECTIVE: In a mixed-methods, feasibility and acceptability study, we adjuncted conventional mentalization-based treatment (MBT) for BPD with avatar software (avatar-MBT)...
October 22, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/29056275/current-and-future-applications-of-novel-immunotherapies-in-urological-oncology-a-critical-review-of-the-literature
#20
REVIEW
Berna C Özdemir, Arlene O Siefker-Radtke, Matthew T Campbell, Sumit K Subudhi
CONTEXT: Immunotherapies promote anticancer responses with varying levels of success based on the tumor type. OBJECTIVE: In this narrative review article, we searched the literature regarding immunotherapies in genitourinary malignancies to define the state of the field, explore future applications of immune checkpoint inhibitors, cytokines, vaccines, and cellular therapies in urological oncology and evaluate possible strategies to improve the selection of patients who might benefit from such approaches...
October 19, 2017: European Urology Focus
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