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https://www.readbyqxmd.com/read/28803259/opportunities-and-challenges-in-the-immunological-therapy-of-pediatric-malignancy-a-concise-snapshot
#1
REVIEW
Francesco Ceppi, Maja Beck-Popovic, Jean-Pierre Bourquin, Raffaele Renella
Over the last 50 years, collaborative clinical trials have reduced the number of children dying from pediatric cancer significantly. Unfortunately, certain tumor types have remained resistant to conventional surgical, radiotherapy and chemotherapy combinations, and relapsing and/or refractory disease remains associated with dismal outcomes. Recently, renewed attention has been given to the role for immunotherapies in pediatric oncology. In fact, these combine several attractive features, including (but possibly not limited to) the specificity for cancer cells, potentially in vivo persistence and longevity, and potency against refractory disease...
August 12, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28789595/personal-narrative-approaches-in-rehabilitation-following-traumatic-brain-injury-a-synthesis-of-qualitative-research
#2
Kate D'Cruz, Jacinta Douglas, Tanya Serry
Although narrative storytelling has been found to assist identity construction, there is little direct research regarding its application in rehabilitation following traumatic brain injury (TBI). The aim of this review was to identify published evidence on the use of personal narrative approaches in rehabilitation following TBI and to synthesise the findings across this literature. A systematic search of four databases was conducted in December 2016. No limit was set on the start date of the search. Personal narrative approaches were defined as direct client participation in sharing personal stories using written, spoken or visual methods...
August 9, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28777998/is-faculty-practice-valuable-the-experience-of-western-australian-nursing-and-midwifery-academics-undertaking-faculty-clinical-practice-a-discussion-paper
#3
Amanda C Fowler, Melanie Baker, Sadie Geraghty
The faculty clinical practice model provides dedicated time for nursing lecturers and educators in a university school of nursing to work with supervision in the clinical environments for an agreed amount of time each year. Allowing academics to partake in faculty clinical practice this way has been shown to update skills and retain clinical competency. Some nursing and midwifery academics believe it is essential to remain clinically current and up-to-date with professional issues in the clinical environments, whereas other academics believe reading current research maintains clinical competency...
July 27, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28775188/telehealth-and-patient-satisfaction-a-systematic-review-and-narrative-analysis
#4
Clemens Scott Kruse, Nicole Krowski, Blanca Rodriguez, Lan Tran, Jackeline Vela, Matthew Brooks
BACKGROUND: The use of telehealth steadily increases as it has become a viable modality to patient care. Early adopters attempt to use telehealth to deliver high-quality care. Patient satisfaction is a key indicator of how well the telemedicine modality met patient expectations. OBJECTIVE: The objective of this systematic review and narrative analysis is to explore the association of telehealth and patient satisfaction in regards to effectiveness and efficiency...
August 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28769992/salivary-proline-rich-protein-may-reduce-tannin-iron-chelation-a-systematic-narrative-review
#5
REVIEW
Nicole M Delimont, Sara K Rosenkranz, Mark D Haub, Brian L Lindshield
BACKGROUND: Tannins are often cited for antinutritional effects, including chelation of non-heme iron. Despite this, studies exploring non-heme iron bioavailability inhibition with long-term consumption have reported mixed results. Salivary proline-rich proteins (PRPs) may mediate tannin-antinutritional effects on non-heme iron bioavailability. AIM: To review evidence regarding biochemical binding mechanisms and affinity states between PRPs and tannins, as well as effects of PRPs on non-heme iron bioavailability with tannin consumption in vivo...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28767007/-i-am-not-a-friend-to-men-embodiment-and-desire-in-magnus-hirschfeld-s-transvestites-case-studies
#6
Emma Heaney
This article reads sexological case studies of the fin-de siècle that contain accounts of trans women's lives in the period. It argues that these sources contradict the diagnostic criteria that doctors determine as the factors that define trans feminine identity in the period: desire for men, social isolation, and tortured bodily dissatisfaction. Chief among these contradictions is the prevalence of the expression of trans women's desire for women and easy participation in women's social and kinship networks...
August 2, 2017: Journal of Lesbian Studies
https://www.readbyqxmd.com/read/28761061/tepapa-a-novel-in-silico-feature-learning-pipeline-for-mining-prognostic-and-associative-factors-from-text-based-electronic-medical-records
#7
Frank Po-Yen Lin, Adrian Pokorny, Christina Teng, Richard J Epstein
Vast amounts of clinically relevant text-based variables lie undiscovered and unexploited in electronic medical records (EMR). To exploit this untapped resource, and thus facilitate the discovery of informative covariates from unstructured clinical narratives, we have built a novel computational pipeline termed Text-based Exploratory Pattern Analyser for Prognosticator and Associator discovery (TEPAPA). This pipeline combines semantic-free natural language processing (NLP), regular expression induction, and statistical association testing to identify conserved text patterns associated with outcome variables of clinical interest...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28742163/debunking-in-a-world-of-tribes
#8
Fabiana Zollo, Alessandro Bessi, Michela Del Vicario, Antonio Scala, Guido Caldarelli, Louis Shekhtman, Shlomo Havlin, Walter Quattrociocchi
Social media aggregate people around common interests eliciting collective framing of narratives and worldviews. However, in such a disintermediated environment misinformation is pervasive and attempts to debunk are often undertaken to contrast this trend. In this work, we examine the effectiveness of debunking on Facebook through a quantitative analysis of 54 million users over a time span of five years (Jan 2010, Dec 2014). In particular, we compare how users usually consuming proven (scientific) and unsubstantiated (conspiracy-like) information on Facebook US interact with specific debunking posts...
2017: PloS One
https://www.readbyqxmd.com/read/28726028/should-we-all-be-scientists-re-thinking-laboratory-research-as-a-calling
#9
Louise Bezuidenhout, Nathaniel A Warne
In recent years there have been major shifts in how the role of science-and scientists-are understood. The critical examination of scientific expertise within the field of Science and Technology Studies (STS) are increasingly eroding notions of the "otherness" of scientists. It would seem to suggest that anyone can be a scientist-when provided with the appropriate training and access to data. In contrast, however, ethnographic evidence from the scientific community tells a different story. Scientists are quick to recognize that not everyone can-or should-be a scientist...
July 19, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28725290/the-discovery-of-the-flammer-syndrome-a-historical-and-personal-perspective
#10
REVIEW
Josef Flammer, Katarzyna Konieczka
This review describes the clinical and basic research that led to the description of Flammer syndrome. It is narrated from a personal perspective. This research was initiated by the observation of an increased long-term fluctuation of visual fields in a subgroup of glaucoma patients. As these patients had strikingly cold hands, peripheral blood flow was tested with a capillary microscopy, and vasospastic syndrome (VS) was diagnosed. Further studies on these patients revealed frequently weakened autoregulation of ocular blood flow and increased flow resistivity in retroocular vessels...
June 2017: EPMA Journal
https://www.readbyqxmd.com/read/28724145/tense-marking-in-the-english-narrative-retells-of-dual-language-preschoolers
#11
Svenja Gusewski, Raúl Rojas
Purpose: This longitudinal study investigated the emergence of English tense marking in young (Spanish-English) dual language learners (DLLs) over 4 consecutive academic semesters, addressing the need for longitudinal data on typical acquisition trajectories of English in DLL preschoolers. Method: Language sample analysis was conducted on 139 English narrative retells elicited from 39 preschool-age (Spanish-English) DLLs (range = 39-65 months). Growth curve models captured within- and between-individual change in tense-marking accuracy over time...
July 26, 2017: Language, Speech, and Hearing Services in Schools
https://www.readbyqxmd.com/read/28723588/shared-decision-making-with-parents-of-acutely-ill-children-a-narrative-review
#12
REVIEW
Paul L Aronson, Eugene D Shapiro, Linda M Niccolai, Liana Fraenkel
BACKGROUND: Shared decision-making (SDM) has mostly been used with adults and parents in the primary care setting, and there is limited knowledge on the use of SDM with parents of acutely ill children. OBJECTIVE: To review the literature on SDM with parents in the management of acutely ill children. DATA SOURCES: We searched MEDLINE, SCOPUS, PsycINFO, the Cochrane Library, and ClinicalTrials.gov for English language studies published from the time of database inception to February, 2017...
July 16, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28693527/social-workers-involvement-in-advance-care-planning-a-systematic-narrative-review
#13
Chong-Wen Wang, Cecilia L W Chan, Amy Y M Chow
BACKGROUND: Advance care planning is a process of discussion that enables competent adults to express their wishes about end-of-life care through periods of decisional incapacity. Although a number of studies have documented social workers' attitudes toward, knowledge about, and involvement in advance care planning, the information is fragmented. The purpose of this review was to provide a narrative synthesis of evidence on social workers' perspectives and experiences regarding implementation of advance care planning...
July 10, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/28688334/-behind-closed-doors-with-open-minds-a-qualitative-study-exploring-nursing-home-staff-s-narratives-towards-their-roles-and-duties-within-the-context-of-sexuality-in-dementia
#14
T Vandrevala, T Chrysanthaki, E Ogundipe
BACKGROUND: Despite sexual expression being recognised as a fundamental human need, sexuality in old age is often ignored and frequently misunderstood, with residents with dementia in a nursing home often viewed as asexual or incapable of being sexually active. OBJECTIVES: The current study aims to understand the views held by nursing care home staff towards dementia and sexuality and explore the roles they may adopt whilst responding and managing sexual needs and expression for residents with dementia...
June 13, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28681485/unlocking-stories-older-women-s-experiences-of-intimate-partner-violence-told-through-creative-expression
#15
Julie McGarry, Dawn Bowden
INTRODUCTION: Intimate partner violence (IPV) exerts a detrimental impact on the lives and health of all who experience abuse. This includes both physical and mental health and wellbeing. The experiences of older women however may be different and these differences may not be recognised or accounted for within existing care provision. AIM: To explore the impact of IPV on the lives and health of older women told from the particular perspective of older women themselves as these accounts are largely absence from existing IPV discourse...
July 6, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/28679000/english-verb-accuracy-of-bilingual-cantonese-english-preschoolers
#16
Stefano Rezzonico, Ahuva Goldberg, Trelani Milburn, Adriana Belletti, Luigi Girolametto
Purpose: Knowledge of verb development in typically developing bilingual preschoolers may inform clinicians about verb accuracy rates during the 1st 2 years of English instruction. This study aimed to investigate tensed verb accuracy in 2 assessment contexts in 4- and 5-year-old Cantonese-English bilingual preschoolers. Method: The sample included 47 Cantonese-English bilinguals enrolled in English preschools. Half of the children were in their 1st 4 months of English language exposure, and half had completed 1 year and 4 months of exposure to English...
July 26, 2017: Language, Speech, and Hearing Services in Schools
https://www.readbyqxmd.com/read/28669013/narrative-medicine-perspectives-on-patient-identity-and-integrative-care-in-neuro-oncology
#17
Robert B Slocum, Tracy A Howard, John L Villano
Narrative Medicine sessions can encourage patients to rediscover personal identity and meaning by telling or writing their stories. We explored this process to improve care and quality of life for brain cancer patients in an academic neuro-oncology program. Brain cancer and its treatments may threaten a patient's quality of life and sense of self in many ways, including impaired cognitive skills, loss of memory, reduced coordination, and limited capacity for self-expression. The impact of symptoms and side effects on quality of life must be evaluated in terms of each patient's identity and may be understood in terms of each patient's story...
July 1, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28668642/thank-you-letters-from-patients-in-an-intensive-care-unit-from-the-expression-of-gratitude-to-an-applied-ethic-of-care
#18
Alexandre Herbland, Michel Goldberg, Nathalie Garric, Olivier Lesieur
INTRODUCTION: Patients' perception of an intensive care unit stay can lead to a better understanding of the expectations and needs of patients hospitalised in intensive care so that care for critically ill patients can be adapted and improved. Thank you letters are sources of original information which come directly and spontaneously from patients. OBJECTIVE: The objective of this study was to analyse the thank you letters from patients who required intensive care treatment and to identify messages that could be intended for the intensive care unit team...
June 28, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28659779/temporality-of-features-in-near-death-experience-narratives
#19
Charlotte Martial, Héléna Cassol, Georgios Antonopoulos, Thomas Charlier, Julien Heros, Anne-Françoise Donneau, Vanessa Charland-Verville, Steven Laureys
Background: After an occurrence of a Near-Death Experience (NDE), Near-Death Experiencers (NDErs) usually report extremely rich and detailed narratives. Phenomenologically, a NDE can be described as a set of distinguishable features. Some authors have proposed regular patterns of NDEs, however, the actual temporality sequence of NDE core features remains a little explored area. Objectives: The aim of the present study was to investigate the frequency distribution of these features (globally and according to the position of features in narratives) as well as the most frequently reported temporality sequences of features...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28653106/from-will-to-live-to-will-to-die-oncologists-nurses-and-social-workers-identification-of-suicidality-in-cancer-patients
#20
Leeat Granek, Ora Nakash, Samuel Ariad, Wendy Chen, Shira Birenstock-Cohen, Shahar Shapira, Merav Ben-David
PURPOSE: The purpose of this research was to examine how oncologists, nurses, and social workers identify suicidality in cancer patients. METHODS: Sixty-one healthcare professionals (23 oncologists, 18 social workers, and 20 nurses) at two academic cancer centers were interviewed using an in-depth interview guide. This was a qualitative study based on grounded theory methodology. Analysis involved line-by-line coding, with categories and themes emerging from participants' narratives...
June 26, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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