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https://www.readbyqxmd.com/read/29333023/nivolumab-pearls-of-evidence
#1
REVIEW
Pratishtha B Chaudhari
Purpose: Nivolumab is one of the most extensively studied immune checkpoint inhibitors across various tumor types. In this narrative review, the current clinical efficacy and safety data of anti-programmed death-1 (PD-1) nivolumab for nonsmall cell lung cancer (NSCLC) and renal cell cancer (RCC) are elucidated. Methods: Systematic search was done on Pubmed, Medline, Embase, Web of Knowledge, and Cochrane Central through September 2016 for controlled prospective interventional studies of nivolumab across two indications - NSCLC and RCC...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29327206/brain-photobiomodulation-therapy-a-narrative-review
#2
REVIEW
Farzad Salehpour, Javad Mahmoudi, Farzin Kamari, Saeed Sadigh-Eteghad, Seyed Hossein Rasta, Michael R Hamblin
Brain photobiomodulation (PBM) therapy using red to near-infrared (NIR) light is an innovative treatment for a wide range of neurological and psychological conditions. Red/NIR light is able to stimulate complex IV of the mitochondrial respiratory chain (cytochrome c oxidase) and increase ATP synthesis. Moreover, light absorption by ion channels results in release of Ca2+ and leads to activation of transcription factors and gene expression. Brain PBM therapy enhances the metabolic capacity of neurons and stimulates anti-inflammatory, anti-apoptotic, and antioxidant responses, as well as neurogenesis and synaptogenesis...
January 11, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29324946/realities-and-perspectives-of-adolescent-mothers-in-their-first-pregnancy
#3
Rita de Cássia Andrade Neiva Santos, Raimunda Magalhães da Silva, Maria Veraci Oliveira Queiroz, Herla Maria Furtado Jorge, Aline Veras Morais Brilhante
OBJECTIVE: to understand the trajectory of adolescents regarding the first pregnancy, contemplating realities and perspectives. METHOD: qualitative study, based on the Schütz theoretical framework, with 30 adolescents assisted in an outpatient clinic for adolescents in Fortaleza, Ceará, Brazil. From the narrative interviews carried out in the first semester of 2013, in the return for the first consultation of the puerperium, the communicative processes were identified, the central ideas and units of meanings expressed in the themes were abstracted: I was dating and became pregnant; realities and perspectives...
January 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29317765/-we-want-to-do-everything-how-parents-represent-their-experiences-with-maternal-fetal-surgery-online
#4
Jessica T Fry, Joel E Frader
OBJECTIVE: There is little available evidence on how patients make decisions regarding maternal-fetal surgery. We studied online patient narratives for insight on how pregnant women and their partners consider such decisions. STUDY DESIGN: We used Google search strings and a purposive snowball method to locate patient blogs. We analyzed blog entries using qualitative methods to identify author details, medical information, and common themes. RESULTS: We located 32 blogs of patients who describe maternal-fetal surgery consultation...
January 9, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29316007/ambivalence-resolution-in-brief-psychotherapy-for-depression
#5
Cátia Braga, António P Ribeiro, Miguel M Gonçalves, João Tiago Oliveira, Alexandra Botelho, Helena Ferreira, Inês Sousa
Ambivalence in the process of psychotherapeutic change should be addressed and resolved if we are to avoid psychotherapeutic failure and promote sustained change. In this context, ambivalence can be defined as the cyclical conflictual relation between two opposed positions of the self: one expressed as an innovation, and a subsequent one expressed in a trivialization or rejection of the innovation (problematic position). This conflict may be resolved in two different ways: (a) the dominance of the innovative position and the consequent inhibition of the problematic one and (b) the negotiation between the innovative and the problematic positions...
January 7, 2018: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/29315558/lessons-from-literature-for-psychotherapy-practice-and-research1
#6
David E Orlinsky
Insights from the study of literature can inform and clarify concepts to guide psychotherapy practice and research. The author offers instances from narrative fiction (Durrell's Alexandria Quartet) and poetry (Hopkins, Baudelaire) to illustrate how the formulation of experience in words that are evocative (vs. ordinary), original (vs. trite), and precise (vs. approximate) are able to capture attention, move the emotions, and challenge beliefs; and how linkages among experiences, vividly and precisely expressed, create and enhance narrative meaning-revealing the inherent relativity of individual meanings and the need to consider the aggregate of relevant perspectives in every interpersonal situation...
January 5, 2018: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29298326/understanding-the-experience-and-manifestation-of-depression-in-adolescents-living-with-hiv-in-harare-zimbabwe
#7
Nicola Willis, Webster Mavhu, Carol Wogrin, Abigail Mutsinze, Ashraf Kagee
BACKGROUND: Studies have found that adolescents living with HIV are at risk of depression, which in turn affects adherence to medication. This study explored the experience and manifestation of depression in adolescents living with HIV in Zimbabwe in order to inform intervention development. METHODS: We conducted a body mapping exercise with 21 HIV positive 15-19 years olds who had been diagnosed with major depressive disorder. Participants created a painted map of their body to assist them in expressing their somatic and emotional experiences in qualitative interviews...
2018: PloS One
https://www.readbyqxmd.com/read/29294799/a-qualitative-analysis-of-physically-aggressive-conflict-episodes-among-a-community-sample
#8
Maria Testa, Laura T Petrocelli, Cory A Crane, Audrey Kubiak, Kenneth E Leonard
Intimate partner aggression among community couples has been conceptualized as representing an occasional, situationally provoked response to a conflict. Yet, relatively few studies have considered the situational factors that contribute to the occurrence of an aggressive episode. The present study used thematic analysis to understand how episodes of physical aggression come about from the participant's perspective. We examined narrative descriptions of relationship conflicts that included physical aggression to gain insight into the types of aggressive incidents experienced, the reasons and motives behind the aggression, and the meaning of these events...
June 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29282241/balancing-sexual-expression-and-risk-of-harm-in-elderly-persons-with-dementia
#9
Jessica Abellard, Carla Rodgers, Alicia L Bales
Assessing decision-making capacity in older individuals with dementia, now known as major neurocognitive disorder (MND), is a complex and challenging endeavor. There is a dearth of literature that touches on the sensitive and controversial topic of sexuality in institutionalized settings, despite the rapid increase in the global population of older individuals. In this article, we assert that evaluations of sexual expression in institutionalized older individuals with MND is essential, as there are concerns specific to risks and benefits of sexual expression in elderly persons with MND that should be considered...
December 2017: Journal of the American Academy of Psychiatry and the Law
https://www.readbyqxmd.com/read/29278262/framing-narrative-journalism-as-a-new-genre-a-case-study-of-the-netherlands
#10
Kobie van Krieken, José Sanders
Although narrative journalism has a long history in the Netherlands, it is in recent years being promoted as a 'new' genre. This study examines the motives underlying this promotional tactic. To that end, we analyze how narrative journalism is framed in (1) public expressions of the initiatives aimed at professionalization of the genre and (2) interviews with journalists and lecturers in journalism programs. Results indicate that in public discourse on narrative journalism, the genre is framed as moving, essential, and as high quality journalism...
November 2017: Journalism (Lond)
https://www.readbyqxmd.com/read/29276986/imagined-futures-in-living-with-multiple-conditions-positivity-relationality-and-hopelessness
#11
Lindsay-Ann Coyle, Sarah Atkinson
Hope serves as an overarching concept for a range of engagements that demonstrate the benefits of a positive outlook for coping with chronic conditions of ill-health and disability. A dominant engagement through medicine has positioned hope as a desirable attribute and its opposite, hopelessness, as pathological. In this engagement hope is individual, internally located and largely cognitive and able to be learned. Attaining hope reflects a process of coming to terms with the losses associated with long-term conditions and of imagining new meanings and purposes for the future ahead...
December 18, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29276804/how-first-year-students-expressed-their-transition-to-college-experiences-differently-depending-on-the-affordances-of-two-writing-contexts
#12
Philip Kreniske
Drawing on theory that positions writing as a social process, this study compares how two distinct contexts influenced the linguistic features of college students' writing over time. In one context, students blogged and received comments, while in the other context students word-processed and received no comments. Systematic qualitative and quantitative analyses of these natural language posts and comments indicated the bloggers used greater rates of cognitive and intensifying expressions in their writing over time than students who word-processed...
September 2017: Computers and Composition
https://www.readbyqxmd.com/read/29259823/-we-lost-because-of-his-drunkenness-the-social-processes-linking-alcohol-use-to-self-harm-in-the-context-of-daily-life-stress-in-marriages-and-intimate-relationships-in-rural-sri-lanka
#13
Jane Brandt Sørensen, Thilini Agampodi, Birgitte Refslund Sørensen, Sisira Siribaddana, Flemming Konradsen, Thilde Rheinländer
Introduction: Harmful alcohol use has been found to cause detriment to the consumers and those around them. Research carried out in Sri Lanka has described the socioeconomic consequences to families owing to alcohol consumption. However, the social processes around alcohol use and how it could result in behaviour such as self-harm was unclear. With an outset in daily life stressors in marriages and intimate relationships we explored alcohol use in families with a recent case of self-harm...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29251065/the-potential-influence-of-led-lighting-on-mental-illness
#14
Michael Bauer, Tasha Glenn, Scott Monteith, John F Gottlieb, Philipp Ritter, John Geddes, Peter C Whybrow
OBJECTIVES: Two recent scientific breakthroughs may alter the treatment of mental illness, as discussed in this narrative review. First, the invention of white light-emitting diodes (LEDs) enabled an ongoing, rapid transition to energy-efficient LEDs for lighting, and the use of LEDs to backlight digital devices. Second was the discovery of melanopsin-expressing photosensitive retinal ganglion cells, which detect environmental irradiance and mediate non-image forming (NIF) functions including circadian entrainment, melatonin secretion, alertness, sleep regulation and the pupillary light reflex...
December 18, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29249718/screen-shots-when-patients-and-families-publish-negative-health-care-narratives-online
#15
Marleen Eijkholt, Jane Jankowski, Marilyn Fisher
Social media sites and their relationship to health care is a subject of intense debate. Common discussions regarding social media address patient privacy, or e-professionalism. This case study explores the tensions that arise for health care providers when negative patient statements surface in social media and blog forums. Recognizing that patients and families often find relief in sharing personal illness narratives, we contemplate if, and how, individual health care professionals and institutions should address complaints aired in public, unmoderated media...
2017: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/29248186/emotional-responses-to-unintentional-and-intentional-traumatic-injuries-among-urban-black-men-a-qualitative-study
#16
Tammy Jiang, Jessica L Webster, Andrew Robinson, Nancy Kassam-Adams, Therese S Richmond
PURPOSE: The burden of injuries is disproportionately concentrated among Black men in the United States. Previous studies suggest that the mental health effects of trauma may vary by the intentionality of the injury (intentional vs. unintentional), yet little is known about this experience among Black men. We explored the emotional responses to traumatic injuries in the context of injury intentionality among Black men in an urban area. METHODS: We conducted semi-structured, qualitative interviews with 74 Black men who were traumatically injured...
December 6, 2017: Injury
https://www.readbyqxmd.com/read/29232962/meaning-in-hoarding-perspectives-of-people-who-hoard-on-clutter-culture-and-agency
#17
David M R Orr, Michael Preston-Shoot, Suzy Braye
Hoarding has become increasingly prominent in clinical practice and popular culture in recent years, giving rise to extensive research and commentary. Critical responses in the social sciences have criticised the cultural assumptions built in to the construct of 'hoarding disorder' and expressed fears that it may generate stigma outweighing its benefits; however, few of these studies have engaged directly with 'hoarders' themselves. This paper reports on in-depth, semi-structured interviews with 10 individuals living in England, who received assessment and intervention for hoarding from Social Services...
December 12, 2017: Anthropology & Medicine
https://www.readbyqxmd.com/read/29228891/adherence-to-asthma-treatment-in-childhood-and-adolescence-a-narrative-literature-review
#18
Kristine Desager, Françoise Vermeulen, Eddy Bodart
OBJECTIVES: We provide a narrative literature review on surveys used to assess the level of medication adherence in children and adolescents with asthma, the attitudes of these patients and their parents toward asthma therapy, and their expectations concerning asthma and available treatment. METHODS: A PubMed search and manual selection of the retrieved papers was conducted to identify studies using surveys or interviews that addressed one of the three topics of interest...
December 11, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29222570/narrative-language-sampling-in-typical-development-implications-for-clinical-trials
#19
Marie Moore Channell, Susan J Loveall, Frances A Conners, Danielle J Harvey, Leonard Abbeduto
Purpose: This study examined cross-sectional age-related trajectories of expressive language variables (syntactic complexity, lexical diversity, unintelligibility, dysfluency, and talkativeness) derived from a narrative language sampling procedure. Method: Narrative samples were analyzed from 103 typically developing individuals, ages 4-21 years. Results: Results showed that this procedure was effective for the entire age range, with participants producing an utterance on virtually every page of the wordless picture books used to prompt the narrative...
December 7, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29219877/effectiveness-of-robotic-assisted-rehabilitation-for-mobility-and-functional-ability-in-adult-stroke-patients-a-systematic-review
#20
Kenneth Lo, Matthew Stephenson, Craig Lockwood
BACKGROUND: Stroke is a leading cause of long-term disability, and rehabilitation, involving repetitive, high intensity, task-specific exercises, is the pathway to restoring motor skills. Robotic assistive devices are increasingly being used and it is hoped that with robotic devices, rehabilitation progress can be achieved for patients. OBJECTIVES: To examine the effectiveness of robotic devices in the rehabilitation of stroke patients for upper limb mobility, lower limb mobility, and activities of daily living...
December 2017: JBI Database of Systematic Reviews and Implementation Reports
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