keyword
MENU ▼
Read by QxMD icon Read
search

Placental tissue

keyword
https://www.readbyqxmd.com/read/28734678/improvement-of-adipose-tissue-derived-cells-by-low-energy-extracorporeal-shock-wave-therapy
#1
Eleni Priglinger, Christina M A P Schuh, Carolin Steffenhagen, Christoph Wurzer, Julia Maier, Sylvia Nuernberger, Wolfgang Holnthoner, Christiane Fuchs, Susanne Suessner, Dominik Rünzler, Heinz Redl, Susanne Wolbank
BACKGROUND: Cell-based therapies with autologous adipose tissue-derived cells have shown great potential in several clinical studies in the last decades. The majority of these studies have been using the stromal vascular fraction (SVF), a heterogeneous mixture of fibroblasts, lymphocytes, monocytes/macrophages, endothelial cells, endothelial progenitor cells, pericytes and adipose-derived stromal/stem cells (ASC) among others. Although possible clinical applications of autologous adipose tissue-derived cells are manifold, they are limited by insufficient uniformity in cell identity and regenerative potency...
July 19, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28733350/adiponectin-limits-differentiation-and-trophoblast-invasion-in-human-endometrial-cells
#2
Fabien Duval, Esther Dos Santos, Hadia Moindjie, Valérie Serazin, Nelly Swierkowski-Blanchard, François Vialard, Marie-Noëlle Dieudonné
Successful human embryo implantation requires a proper differentiation of endometrial stromal cells (ESCs) into decidual cells, during a process called decidualization. ESCs express specific molecules, as prolactin, insulin-like growth factor-binding protein-1 (IGFBP-1), and connexin-43. Decidual cells are also involved in the control of trophoblast invasion, by secreting various factors, as matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Adiponectin is an adipokine with insulin-sensitizing, anti-inflammatory, and anti-proliferative effects...
July 21, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28731129/expression-profile-of-c19mc-micrornas-in-placental-tissue-of-patients-with-preterm-prelabor-rupture-of-membranes-and-spontaneous-preterm-birth
#3
Ilona Hromadnikova, Katerina Kotlabova, Katarina Ivankova, Ladislav Krofta
The aim of the study was to demonstrate that preterm birth (PTB) is associated with altered C19MC microRNA expression profile in placental tissues. Gene expression of 15 placental specific microRNAs (miR‑512‑5p, miR‑515‑5p, miR‑516‑5p, miR‑517‑5p, miR‑518b, miR‑518f‑5p, miR‑519a, miR‑519d, miR‑519e‑5p, miR‑520a‑5p, miR‑520h, miR‑524‑5p, miR‑525‑5p, miR‑526a and miR‑526b‑5p) was compared between groups: 34 spontaneous PTB, 108 preterm prelabor rupture of membranes (PPROM) and 20 term in labor pregnancies...
July 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28724925/a-comparative-study-of-five-physiological-key-parameters-between-four-different-human-trophoblast-derived-cell-lines
#4
Mario Rothbauer, Nilaykumar Patel, Hajnalka Gondola, Monika Siwetz, Berthold Huppertz, Peter Ertl
The human placenta plays a crucial role as the interface between mother and fetus. It represents a unique tissue that undergoes morphological as well as functional changes on the cellular and tissue level throughout pregnancy. To better understand how the placenta works, a variety of techniques has been developed to re-create this complex physiological barrier in vitro. However, due to the low availability of freshly isolated primary cells, choriocarcinoma cell lines remain the usual suspects as in vitro models for placental research...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28722160/placental-proteomics-reveal-insights-into-fetal-alcohol-spectrum-disorders
#5
Katie L Davis-Anderson, Sebastian Berger, Emilie R Lunde-Young, Vishal D Naik, Heewon Seo, Greg A Johnson, Hanno Steen, Jayanth Ramadoss
Fetal alcohol spectrum disorders (FASD) describe many of the well-known neurodevelopmental deficits afflicting children exposed to alcohol in utero. The effects of alcohol on the maternal-fetal interface, especially the placenta, have been less explored. We herein hypothesized that chronic binge alcohol exposure during pregnancy significantly alters the placental protein profile in a rat FASD model METHODS: Pregnant rats were orogastrically treated daily with alcohol (4.5 g/kg, gestational day (GD) 5-10; 6...
July 19, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28719804/maternal-obesity-attenuates-predelivery-inflammatory-reaction-in-c57bl-6n-mice
#6
Sarah Appel, Merle Schulze-Edinghausen, Tobias Kretschmer, Sarah Storck, Ruth Janoschek, Inga Bae-Gartz, Marion Handwerk, Maria Wohlfarth, Kai-Dietrich Nüsken, Eva Hucklenbruch-Rother, Malte Heykants, Esther Mahabir, Jörg Dötsch
Inflammation and oxidative stress are known to increase before labour. Whether gonadal white adipose tissue (gWAT) participates in this process and whether labour-related processes in placental and adipose tissue are altered in obese women is unknown. In our mouse model, lean mice display elevated placental inflammation and oxidative stress towards the end of pregnancy, accompanied by an increased expression of pro-inflammatory factors in gWAT. Obese mice also display elevated levels of pro-inflammatory factors and oxidative stress in placentas shortly before birth...
July 1, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28719152/a-first-in-human-phase-i-multicenter-open-label-dose-escalation-study-of-the-oral-raf-vegfr-2-inhibitor-raf265-in-locally-advanced-or-metastatic-melanoma-independent-from-braf-mutation-status
#7
Benjamin Izar, William Sharfman, F Stephen Hodi, Donald Lawrence, Keith T Flaherty, Ravi Amaravadi, Kevin B Kim, Igor Puzanov, Jeffrey Sosman, Reinhard Dummer, Simone M Goldinger, Lyhping Lam, Shefali Kakar, Zhongwen Tang, Oliver Krieter, David F McDermott, Michael B Atkins
To establish the maximum tolerated dose (MTD), dose-limiting toxicities (DLT), safety profile, and anti-tumor efficacy of RAF265. We conducted a multicenter, open-label, phase-I, dose-escalation trial of RAF265, an orally available RAF kinase/VEGFR-2 inhibitor, in patients with advanced or metastatic melanoma. Pharmacokinetic (PK) analysis, pharmacodynamics (PD) and tumor response assessment were conducted. We evaluated metabolic tumor response by 18[F]-fluorodeoxyglucose-positron-emission tomography (FDG-PET), tissue biomarkers using immunohistochemistry (IHC), and modulators of angiogenesis...
July 18, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28717241/sca-1-identifies-a-trophoblast-population-with-multipotent-potential-in-the-mid-gestation-mouse-placenta
#8
Bryony V Natale, Christina Schweitzer, Martha Hughes, Maria A Globisch, Ramie Kotadia, Emilie Tremblay, Priscilla Vu, James C Cross, David R C Natale
Trophoblast stem (TS) cells in the mouse derive from the polar trophectoderm of the blastocyst and persist through early gestation (to E8.5) to support placental development. Further development and growth is proposed to rely on layer-restricted progenitor cells. Stem cell antigen (Sca) -1 is a member of the Ly6 gene family and a known marker of stem cells in both hematopoietic and non-hematopoietic mouse tissues. Having identified that Sca-1 mRNA was highly expressed in mouse TS cells in culture, we found that it was also expressed in a subset of trophoblast within the chorion and labyrinth layer of the mouse placenta...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717128/mother-s-pre-pregnancy-bmi-and-placental-candidate-mirnas-findings-from-the-environage-birth-cohort
#9
Maria Tsamou, Dries S Martens, Ellen Winckelmans, Narjes Madhloum, Bianca Cox, Wilfried Gyselaers, Tim S Nawrot, Karen Vrijens
There is increasing evidence that the predisposition for development of chronic diseases arises at the earliest times of life. In this context, maternal pre-pregnancy weight might modify fetal metabolism and the child's predisposition to develop disease later in life. The aim of this study is to investigate the association between maternal pre-pregnancy body mass index (BMI) and miRNA alterations in placental tissue at birth. In 211 mother-newborn pairs from the ENVIRONAGE birth cohort, we assessed placental expression of seven miRNAs important in crucial cellular processes implicated in adipogenesis and/or obesity...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28715784/elemental-content-of-the-placenta-a-comparison-between-two-high-risk-obstetrical-populations-adult-women-carrying-multiples-and-adolescents-carrying-singletons
#10
Paolo de Angelis, Richard K Miller, Thomas H Darrah, Philip J Katzman, Eva K Pressman, Tera R Kent, Kimberly O O'Brien
BACKGROUND: The placenta is responsible for the exchange of nutrients and for preventing harmful compounds from entering the fetal circulation. With increasing industrialization, exposures to commercial and toxic metals become a concern for both pregnant women and those planning a pregnancy. The understanding of transport mechanisms and pharmacokinetics for most inorganic elements is incomplete and limited to normal term deliveries. OBJECTIVES: To obtain novel data on 46 inorganic elements in placentae from two high-risk obstetric populations, women carrying multiples and adolescents carrying singletons, evaluating differences, if present, and identifying predictors of placental content...
July 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28714012/knockdown-of-jarid2-inhibits-the-viability-and-migration-of-placenta-trophoblast-cells-in-preeclampsia
#11
Yatao Jiang, Yuqing Chen, Yanping Chen
Protein Jumonji (JARID2) is a member of the Jumonji family of proteins and has been demonstrated to regulate cell proliferation and invasion. However, little is known about the role of JARID2 in the metastasis of placenta trophoblast cells. In the present study, the effect and the underlying molecular mechanism of JARID2 on trophoblast cell viability and invasion was investigated. The expression of JARID2 in placental tissues was analyzed by reverse transcription‑quantitative polymerase chain reaction and western blotting...
July 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28709848/hydrogen-sulfide-alleviates-placental-injury-induced-by-maternal-cigarette-smoke-exposure-during-pregnancy-in-rats
#12
Fusheng Zhao, Fang Lei, Senfeng Zhang, Xiang Yan, Wen Wang, Yu Zheng
Maternal cigarette smoke exposure (CSE) during pregnancy is a well recognized causative factor for placental injury. Hydrogen sulfide (H2S), a gaseous signal molecule, has been shown to exert a protective effect against tissue injury in many organs. This study aimed to investigate whether H2S could alleviate CSE-induced placental injury in rats. Pregnant SD rats were randomly divided into 4 groups: NaCl, CSE, CSE + NaHS (a donor of H2S) and NaHS. On gestational day 21, placental weight was measured. Placental H2S content was assessed by methylene blue method...
July 11, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28708997/vaccine-mediated-protection-against-zika-virus-induced-congenital-disease
#13
Justin M Richner, Brett W Jagger, Chao Shan, Camila R Fontes, Kimberly A Dowd, Bin Cao, Sunny Himansu, Elizabeth A Caine, Bruno T D Nunes, Daniele B A Medeiros, Antonio E Muruato, Bryant M Foreman, Huanle Luo, Tian Wang, Alan D Barrett, Scott C Weaver, Pedro F C Vasconcelos, Shannan L Rossi, Giuseppe Ciaramella, Indira U Mysorekar, Theodore C Pierson, Pei-Yong Shi, Michael S Diamond
The emergence of Zika virus (ZIKV) and its association with congenital malformations has prompted the rapid development of vaccines. Although efficacy with multiple viral vaccine platforms has been established in animals, no study has addressed protection during pregnancy. We tested in mice two vaccine platforms, a lipid nanoparticle-encapsulated modified mRNA vaccine encoding ZIKV prM and E genes and a live-attenuated ZIKV strain encoding an NS1 protein without glycosylation, for their ability to protect against transmission to the fetus...
July 13, 2017: Cell
https://www.readbyqxmd.com/read/28708523/timing-of-transcriptomic-and-proteomic-changes-in-the-bovine-placentome-after-parturition
#14
Anthony K McNeel, Jeff D Ondrak, Olivia L Amundson, Tara H Fountain, Elane C Wright, Katherine J Whitman, Carol G Chitko-McKown, Shuna A Jones, Chadwick C Chase, Robert A Cushman
Proper post-partum reproductive performance is important for reproductive efficiency in beef cows, and dystocia decreases post-partum fertility. Crossbred beef cows (n = 1676) were evaluated for lifetime performance based on degree of dystocia at presentation of the first calf. Cows that experienced moderate or severe dystocia produced fewer calves during their productive life (P < 0.01). The exact mechanism is unclear, but may be due to the contributions of dystocia to abnormal placental separation...
May 27, 2017: Theriogenology
https://www.readbyqxmd.com/read/28707738/prenatal-exposure-to-dexamethasone-in-the-mouse-induces-sex-specific-differences-in-placental-gene-expression
#15
Ji-Yeon Lee, Hyo Jung Yun, Clara Yuri Kim, Yong Woo Cho, Yongmin Lee, Myoung Hee Kim
Prenatal stress during pregnancy leads to sex-specific effects on fetal development and disease susceptibility over the life span; however, the origin of sex differences has not been identified. The placenta not only plays a key role in fetal growth and development throughout pregnancy, but also affects the fetal programming underlying subsequent adult health and accounts. Therefore, sex-specific adaptation of the placenta may be central to the sex differences in fetal growth and survival. Here, we analyzed the effects of prenatal dexamethasone (Dex) on sex-specific changes in placental gene expression using RNA-Seq...
July 14, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/28706989/inactivation-of-thermogenic-ucp1-as-a-historical-contingency-in-multiple-placental-mammal-clades
#16
Michael J Gaudry, Martin Jastroch, Jason R Treberg, Michael Hofreiter, Johanna L A Paijmans, James Starrett, Nathan Wales, Anthony V Signore, Mark S Springer, Kevin L Campbell
Mitochondrial uncoupling protein 1 (UCP1) is essential for nonshivering thermogenesis in brown adipose tissue and is widely accepted to have played a key thermoregulatory role in small-bodied and neonatal placental mammals that enabled the exploitation of cold environments. We map ucp1 sequences from 133 mammals onto a species tree constructed from a ~51-kb sequence alignment and show that inactivating mutations have occurred in at least 8 of the 18 traditional placental orders, thereby challenging the physiological importance of UCP1 across Placentalia...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28705031/barium-exposure-increases-the-risk-of-congenital-heart-defects-occurrence-in-offspring
#17
Nannan Zhang, Zhen Liu, Xiaoxian Tian, Ming Chen, Ying Deng, Yixiong Guo, Nana Li, Ping Yu, Jiaxiang Yang, Jun Zhu
CONTEXT: Several studies have investigated the association between heavy metal exposure and congenital heart defects (CHDs). However, there are limited data regarding the relationship between barium exposure and the occurrence of CHDs. The objective of this study was to analyze the association between barium exposure in mothers and the risk of CHD in offspring. MATERIALS AND METHODS: We developed a case-control study with 399 cases and 490 controls with normal live births in China...
July 14, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28703916/down-regulation-of-microrna-let-7d-inhibits-the-proliferation-and-invasion-of-trophoblast-cells-in-preeclampsia
#18
Xu Dai, Yan Cai
Preeclampsia (PE) is a serious pregnancy complication that continues to adverse effects on mother and the fetus. The study investigated the effect of microRNA let-7d (miR-let-7d) on the proliferation and invasion of trophoblast cells (TC) in PE. In situ hybridization techniques were employed to evaluate the miR-let-7d expressions in the placental tissues from 63 PE patients as well as 65 normal placental tissues. Transfection of pre-let-7d, anti-let-7d and their corresponding control sequences was performed in TCs obtained from PE...
July 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28700642/bacterial-communities-found-in-placental-tissues-are-associated-with-severe-chorioamnionitis-and-adverse-birth-outcomes
#19
Ronan M Doyle, Kathryn Harris, Steve Kamiza, Ulla Harjunmaa, Ulla Ashorn, Minyanga Nkhoma, Kathryn G Dewey, Kenneth Maleta, Per Ashorn, Nigel Klein
Preterm birth is a major cause of neonatal mortality and morbidity worldwide. Bacterial infection and the subsequent inflammatory response are recognised as an important cause of preterm birth. It is hypothesised that these organisms ascend the cervical canal, colonise placental tissues, cause chorioamnionitis and in severe cases infect amniotic fluid and the foetus. However, the presence of bacteria within the intrauterine cavity does not always precede chorioamnionitis or preterm birth. Whereas previous studies observing the types of bacteria present have been limited in size and the specificity of a few predetermined organisms, in this study we characterised bacteria found in placental tissues from a cohort of 1391 women in rural Malawi using 16S ribosomal RNA gene sequencing...
2017: PloS One
https://www.readbyqxmd.com/read/28699189/human-papillomavirus-infects-placental-trophoblast-and-hofbauer-cells-but-appears-not-to-play-a-causal-role-in-miscarriage-and-preterm-labor
#20
Lea Maria Margareta Ambühl, Anne Katrine Leonhard, Carina Widen Zakhary, Annemette Jørgensen, Jan Blaakaer, Karen Dybkaer, Ulrik Baandrup, Niels Uldbjerg, Suzette Sørensen
INTRODUCTION: Recently, an association between human papillomavirus (HPV) infection and both spontaneous abortion and spontaneous preterm delivery was suggested. However, the reported HPV prevalence in pregnant women varies considerably and reliable conclusions are difficult. We aimed to investigate HPV infection in placental tissue of a Danish study cohort. Furthermore, we studied the cellular localization of HPV. MATERIAL AND METHODS: In this prospective case-control study, placental tissue was analyzed for HPV infection by nested PCR in the following four study groups: full-term delivery (n=103), spontaneous preterm delivery (n=69), elective abortion (n=54), and spontaneous abortion (n=44)...
July 12, 2017: Acta Obstetricia et Gynecologica Scandinavica
keyword
keyword
7422
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"