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https://www.readbyqxmd.com/read/27708857/risk-stratification-of-patients-with-chronic-heart-failure-using-cardiac-iodine-123-metaiodobenzylguanidine-imaging-incremental-prognostic-value-over-right-ventricular-ejection-fraction
#1
Shunsuke Tamaki, Takahisa Yamada, Takashi Morita, Yoshio Furukawa, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Takumi Kondo, Tsutomu Kawai, Satoshi Takahashi, Masashi Ishimi, Hideyuki Hakui, Tatsuhisa Ozaki, Yoshihiro Sato, Masahiro Seo, Yasushi Sakata, Masatake Fukunami
AIMS: Right ventricular (RV) systolic dysfunction has been shown to be an independent predictor of clinical outcome in patients with chronic heart failure (CHF), and cardiac metaiodobenzylguanidine (MIBG) imaging also provides prognostic information. We aimed to evaluate the long-term predictive value of combining RV systolic dysfunction and abnormal findings of cardiac MIBG imaging on outcome in CHF patients. METHODS AND RESULTS: We enrolled 63 CHF outpatients with left ventricular ejection fraction (EF) <40% in a prospective cohort study...
December 2015: ESC Heart Failure
https://www.readbyqxmd.com/read/27323278/contraction-bands-are-induced-by-cardiac-massage-itself
#2
Satomu Morita, Satoshi Furukawa, Katsuji Nishi, Masahito Hitosugi
Pathological contraction bands (CB) are recognized as a type of necrosis pattern found in the myocardium. It is well known that CB are induced by cardiopulmonary resuscitation (CPR) with cardiac massage. However, it is not known whether the reperfusion or massage itself causes the formation of CB. We studied 10 cardiac tissues taken from forensic autopsy cases that had not received CPR. We excluded the cases where the cause of death was a cardiac event. After making sections for forensic research, we massaged the left ventricles for 10 minutes...
September 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/26969366/primary-neuroendocrine-tumour-of-the-right-ventricle-presenting-with-heart-failure-and-cyanosis
#3
Syed Yaseen Naqvi, David Henry, Satoshi Furukawa, Howard Haber
A 68-year-old woman presented to the emergency department owing to exertional dyspnoea and bilateral leg oedema for 3 weeks. Her vital signs included the following: heart rate of 95 bpm, respiratory rate of 24 breaths/min, oxygen saturation of 73% on room air and a blood pressure of 184/108 mm Hg. Physical examination revealed tachypnoea with clear lungs to auscultation, elevated jugular veins, cyanosis and bilateral pitting oedema. A chest X-ray demonstrated cardiomegaly without obvious pulmonary oedema. A CT of the chest was negative for pulmonary embolus; however, the scan did reveal a large right ventricular (RV) mass...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/26351097/risk-stratification-for-ventricular-tachyarrhythmias-by-ambulatory-electrocardiogram-based-frequency-domain-t-wave-alternans
#4
Masato Kawasaki, Takahisa Yamada, Takashi Morita, Yoshio Furukawa, Shunsuke Tamaki, Yusuke Iwasaki, Atsushi Kikuchi, Takumi Kondo, Satoshi Takahashi, Tsutomu Kawai, Yuji Okuyama, Yasushi Sakata, Masatake Fukunami
BACKGROUND: Ambulatory electrocardiogram (ECG)-based T-wave alternans (TWA) quantified by the modified moving average method (MMA) can be used to identify patients at risk for sudden cardiac death. However, there is no information available on ambulatory ECG-based TWA as quantified by the frequency domain (FD) method to identify patients with an implantable cardioverter defibrillator (ICD) who are at high risk for ventricular tachyarrhythmias. Further, there are few data regarding the comparison of clinical utility of FD-TWA with MMA-TWA, heart rate variability (HRV), and heart rate turbulence (HRT)...
December 2015: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/26022139/high-density-lipoprotein-cholesterol-levels-and-cardiovascular-outcomes-in-japanese-patients-after-percutaneous-coronary-intervention-a-report-from-the-credo-kyoto-registry-cohort-2
#5
MULTICENTER STUDY
Masayasu Izuhara, Koh Ono, Hiroki Shiomi, Takeshi Morimoto, Yutaka Furukawa, Yoshihisa Nakagawa, Satoshi Shizuta, Tomohisa Tada, Junichi Tazaki, Takahiro Horie, Yasuhide Kuwabara, Osamu Baba, Tomohiro Nishino, Toru Kita, Takeshi Kimura
OBJECTIVE: To determine whether low HDL-C is a risk factor for adverse cardiovascular events in patients with known CAD. METHODS: We evaluated 10,391 patients who underwent PCI from January 2005 to December 2007. In total, 3838 (36.9%) patients had low HDL-C (HDL-C <40 mg/dL in males and <50 mg/dL in females) and 6553 (63.1%) patients had normal HDL-C based on measurements on admission. RESULTS: The unadjusted 5-year incidence of major adverse cardiac events (MACE: composite of cardiovascular death, myocardial infarction or stroke) was significantly higher in the low HDL-C group than in the normal HDL-C group (17...
October 2015: Atherosclerosis
https://www.readbyqxmd.com/read/25982958/an-autopsy-case-of-fatal-repellent-air-freshener-poisoning
#6
Masahito Hitosugi, Chie Tsukada, Shinobu Yamauchi, Kazumi Matsushima, Satoshi Furukawa, Satomu Morita, Toshiaki Nagai
We describe a first fatal case of repellent air freshener ingestion. A 79-year-old Japanese man with Alzheimer-type senile dementia orally ingested repellent air freshener containing three surfactants: polyoxyethylene 9-lauryl ether, polyoxyethylene (40) hydrogenated castor oil, and lauric acid amidopropyl amine oxide (weight ratio of 1.3%). About 1h after the collapse, he was in cardiopulmonary arrest and subsequently died 10h after his arrival. The forensic autopsy performed 5.5h after death revealed the 380ml of stomach contents with a strong mint perfume identical to that of the repellent air freshener and the findings of acute death...
September 2015: Legal Medicine
https://www.readbyqxmd.com/read/25851796/usefulness-of-cardiac-meta-iodobenzylguanidine-imaging-to-identify-patients-with-chronic-heart-failure-and-left-ventricular-ejection-fraction-35-at-low-risk-for-sudden-cardiac-death
#7
Tsutomu Kawai, Takahisa Yamada, Shunsuke Tamaki, Takashi Morita, Yoshio Furukawa, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Takumi Kondo, Satoshi Takahashi, Masashi Ishimi, Hideyuki Hakui, Tatsuhisa Ozaki, Yoshihiro Sato, Masahiro Seo, Yasushi Sakata, Masatake Fukunami
Patients with chronic heart failure (CHF) at risk of sudden cardiac death (SCD) are often treated with implantable cardiac defibrillators (ICDs). However, current criteria for device use that is based largely on left ventricular ejection fraction (LVEF) lead to many patients receiving ICDs that never deliver therapy. It is of clinical significance to identify patients who do not require ICDs. Although cardiac I-123 meta-iodobenzylguanidine (MIBG) imaging provides prognostic information about CHF, whether it can identify patients with CHF who do not require an ICD remains unclear...
June 1, 2015: American Journal of Cardiology
https://www.readbyqxmd.com/read/25654745/classification-of-contraction-bands-using-immunohistochemistry
#8
Satomu Morita, Satoshi Furukawa, Katsuji Nishi
Pathological contraction bands (CBs) are a type of necrosis pattern found in the myocardium. The composition of CB is not well studied. This is because CBs have diverse forms and can be observed in various causes of death. In pathology fields, CBs are classified artifactual CB and CB necrosis. We have identified different forms of CB by examining the expression and distribution of complement component C9 (CCC9) and Sirtuin1 by immunohistochemistry in the myocardium of patients who died because of different causes of death...
March 2015: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/24122590/long-term-safety-and-efficacy-of-sirolimus-eluting-stents-versus-bare-metal-stents-in-real-world-clinical-practice-in-japan
#9
Takeshi Kimura, Takeshi Morimoto, Yutaka Furukawa, Yoshihisa Nakagawa, Kazushige Kadota, Masashi Iwabuchi, Satoshi Shizuta, Hiroki Shiomi, Tomohisa Tada, Junichi Tazaki, Yoshihiro Kato, Mamoru Hayano, Mitsuru Abe, Takashi Tamura, Manabu Shirotani, Shinji Miki, Mitsuo Matsuda, Mamoru Takahashi, Katsuhisa Ishii, Masaru Tanaka, Takeshi Aoyama, Osamu Doi, Ryuichi Hattori, Ryozo Tatami, Satoru Suwa, Akinori Takizawa, Yoshiki Takatsu, Masaaki Takahashi, Hiroshi Kato, Teruki Takeda, Jong-Dae Lee, Ryuji Nohara, Hisao Ogawa, Chuwa Tei, Minoru Horie, Hirofumi Kambara, Hisayoshi Fujiwara, Kazuaki Mitsudo, Masakiyo Nobuyoshi, Toru Kita
Long-term safety and efficacy of drug-eluting stents remains controversial. The CREDO-Kyoto registry cohort-2 is a physician-initiated non-company sponsored multi-center registry enrolling consecutive patients undergoing first coronary revascularization in 26 centers in Japan. We compared 3-year outcome between patients treated with sirolimus-eluting stent (SES) only (5092 patients) and bare-metal stent (BMS) only (5405 patients). SES-use as compared with BMS-use was associated with significantly lower adjusted risk for all-cause death [hazard ratio (HR) [95% confidence interval (CI)] 0...
September 2011: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/23998544/prognostic-implications-of-anemia-with-or-without-chronic-kidney-disease-in-patients-undergoing-elective-percutaneous-coronary-intervention
#10
Yuichiro Kitai, Neiko Ozasa, Takeshi Morimoto, Bingyuan Bao, Yutaka Furukawa, Yoshihisa Nakagawa, Kazushige Kadota, Motoko Yanagita, Satoshi Shizuta, Takeshi Kimura
BACKGROUND: Little is known about the prognostic implications of anemia in patients undergoing elective percutaneous coronary intervention (PCI), especially when they have coexisting chronic kidney disease (CKD). METHODS: We identified 7299 patients who underwent elective PCI from the CREDO-Kyoto registry cohort-2. The primary outcome was 3-year major adverse cardiac events (MACE); composite of all cause death, heart failure hospitalization, and myocardial infarction...
October 15, 2013: International Journal of Cardiology
https://www.readbyqxmd.com/read/23127614/%C3%AE-blocker-use-in-patients-after-percutaneous-coronary-interventions-one-size-fits-all-worse-outcomes-in-patients-without-myocardial-infarction-or-heart-failure
#11
MULTICENTER STUDY
Neiko Ozasa, Takeshi Morimoto, Bingyuan Bao, Yutaka Furukawa, Yoshihisa Nakagawa, Kazushige Kadota, Masashi Iwabuchi, Satoshi Shizuta, Hiroki Shiomi, Junichi Tazaki, Masahiro Natsuaki, Takeshi Kimura
BACKGROUND: The influence of β-blocker therapy on prognosis in patients with coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI) has not been fully explored. METHODS AND RESULTS: We identified 5288 CAD patients who did not have myocardial infarction (MI) or heart failure (HF) but underwent PCI from a large multi-center registry enrolling consecutive patients undergoing first coronary revascularization from 2005 to 2007. The primary outcome was a composite endpoint of cardiac death and/or MI (cardiac death/MI) at 3 years after hospital discharge for PCI...
September 30, 2013: International Journal of Cardiology
https://www.readbyqxmd.com/read/23054967/%C3%AE-blocker-therapy-and-cardiovascular-outcomes-in-patients-who-have-undergone-percutaneous-coronary-intervention-after-st-elevation-myocardial-infarction
#12
MULTICENTER STUDY
Bingyuan Bao, Neiko Ozasa, Takeshi Morimoto, Yutaka Furukawa, Yoshihisa Nakagawa, Kazushige Kadota, Masashi Iwabuchi, Satoshi Shizuta, Hiroki Shiomi, Tomohisa Tada, Junichi Tazaki, Yoshihiro Kato, Mamoru Hayano, Masahiro Natsuaki, Hisayoshi Fujiwara, Kazuaki Mitsudo, Masakiyo Nobuyoshi, Toru Kita, Takeshi Kimura
The effect of β-blockers in ST-elevation myocardial infarction (STEMI) patients who have undergone primary percutaneous coronary intervention (PCI) has not been adequately evaluated. Using a large multi-center registry in Japan, we identified 3,692 patients who underwent PCI within 24 h from onset of STEMI and were discharged alive from 2005 to 2007. Three-year cardiovascular outcomes were compared between the 2 groups of patients with (N = 1,614) or without (N = 2,078) β-blocker prescription at discharge...
April 2013: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/22888162/impact-of-aortic-regurgitation-on-the-prognosisof-severe-aortic-stenosis
#13
COMPARATIVE STUDY
Satoshi Honda, Takeshi Kitai, Yukikatsu Okada, Tomoko Tani, Kitae Kim, Shuichiro Kaji, Natsuhiko Ehara, Makoto Kinoshita, Atsushi Kobori, Atsushi Yamamuro, Toru Kita, Yutaka Furukawa
OBJECTIVE: Many patients with aortic stenosis (AS) have coexisting aortic regurgitation (AR). However, few data exist regarding its clinical significance and prognostic value. The aim of this study was to examine the effect of concomitant significant AR on clinical outcomes in patients with non-surgically treated severe AS. DESIGN: A single centre, retrospective cohort study. PATIENTS AND METHODS: We retrospectively reviewed 306 consecutive patients (age, 72±11 years) with severe AS in whom non-surgical management was primarily planned at our institution between January 1999 and December 2011...
November 2012: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/22739119/disease-characterization-using-lqts-specific-induced-pluripotent-stem-cells
#14
Toru Egashira, Shinsuke Yuasa, Tomoyuki Suzuki, Yoshiyasu Aizawa, Hiroyuki Yamakawa, Tomohiro Matsuhashi, Yohei Ohno, Shugo Tohyama, Shinichiro Okata, Tomohisa Seki, Yusuke Kuroda, Kojiro Yae, Hisayuki Hashimoto, Tomofumi Tanaka, Fumiyuki Hattori, Toshiaki Sato, Shunichiro Miyoshi, Seiji Takatsuki, Mitsushige Murata, Junko Kurokawa, Tetsushi Furukawa, Naomasa Makita, Takeshi Aiba, Wataru Shimizu, Minoru Horie, Kaichiro Kamiya, Itsuo Kodama, Satoshi Ogawa, Keiichi Fukuda
AIMS: Long QT syndrome (LQTS) is an inheritable and life-threatening disease; however, it is often difficult to determine disease characteristics in sporadic cases with novel mutations, and more precise analysis is necessary for the successful development of evidence-based clinical therapies. This study thus sought to better characterize ion channel cardiac disorders using induced pluripotent stem cells (iPSCs). METHODS AND RESULTS: We reprogrammed somatic cells from a patient with sporadic LQTS and from controls, and differentiated them into cardiomyocytes through embryoid body (EB) formation...
September 1, 2012: Cardiovascular Research
https://www.readbyqxmd.com/read/22271387/the-cause-of-b-type-natriuretic-peptide-elevation-and-the-dose-dependent-effect-of-angiotensin-converting-enzyme-inhibitor-on-patients-late-after-tetralogy-of-fallot-repair
#15
Takuo Furukawa, Tomoaki Murakami, Michihiko Ueno, Atsuhito Takeda, Satoshi Yakuwa, Hirokuni Yamazawa
Patients after surgical repair of tetralogy of Fallot (TOF) may experience various complications that result in neurohormonal activation, including plasma B-type natriuretic peptide (BNP) elevation. Right ventricular (RV) dilation is a frequent complication, and few treatments are available. This study aimed to identify the factor or factors leading to BNP elevation and to clarify the effects of angiotensin-converting enzyme inhibitor (ACE-I) on changes in BNP levels in patients with repaired TOF. Plasma BNP levels and hemodynamic data derived from cardiac catheterization were analyzed...
February 2012: Pediatric Cardiology
https://www.readbyqxmd.com/read/21954228/clinical-outcomes-in-non-surgically-managed-patients-with-very-severe-versus-severe-aortic-stenosis
#16
COMPARATIVE STUDY
Takeshi Kitai, Satoshi Honda, Yukikatsu Okada, Tomoko Tani, Kitae Kim, Shuichiro Kaji, Natsuhiko Ehara, Makoto Kinoshita, Atsushi Kobori, Atsushi Yamamuro, Toru Kita, Yutaka Furukawa
OBJECTIVE: The management of asymptomatic severe and very severe aortic stenosis (AS) remains unestablished. This study aimed to investigate the clinical outcomes of severe versus very severe AS patients. DESIGN: A single centre, retrospective cohort study. PATIENTS AND METHODS: The study retrospectively reviewed 108 conservatively treated patients with severe AS (a maximal jet velocity ≥ 4.0 m/s, or mean aortic pressure gradient (MPG) ≥ 40 mm Hg, or an aortic valve area (AVA) <1...
December 2011: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/21843254/left-ventricular-torsion-and-strain-in-patients-with-repaired-tetralogy-of-fallot-assessed-by-speckle-tracking-imaging
#17
Hirobumi Takayasu, Ken Takahashi, Kiyohiro Takigiku, Satoshi Yasukochi, Takeshi Furukawa, Katsumi Akimoto, Masahiko Kishiro, Toshiaki Shimizu
BACKGROUND: In patients with tetralogy of Fallot (TOF), left ventricular (LV) dysfunction is an important factor associated with poor clinical outcome. OBJECTIVE: The purpose of this study was to investigate the torsion and multidirectional strain of the LV in patients with TOF. METHODS: Echocardiographic images were prospectively acquired in 29 patients who underwent TOF repair (age range, 5-25 years) and in 29 normal controls. Torsion and circumferential and longitudinal strain of the LV were assessed using speckle tracking imaging...
August 2011: Echocardiography
https://www.readbyqxmd.com/read/21262207/hydrocephalus-and-abnormal-subcommissural-organ-in-mice-lacking-presenilin-1-in-wnt1-cell-lineages
#18
Mitsunari Nakajima, Keiko Matsuda, Naho Miyauchi, Yasuyoshi Fukunaga, Sono Watanabe, Satoshi Okuyama, Juan Pérez, Pedro Fernández-Llebrez, Jie Shen, Yoshiko Furukawa
Presenilin-1 (PS1) is a transmembrane protein that is in many cases responsible for the development of familial Alzheimer's disease. PS1 is widely expressed in embryogenesis and is essential for neurogenesis, somitogenesis, angiogenesis, and cardiac morphogenesis. To further investigate the role of PS1 in the brain, we inactivated the PS1 gene in Wnt1 cell lineages using the Cre-loxP recombination system. Here we show that conditional inactivation of PS1 in Wnt1 cell lineages results in congenital hydrocephalus and subcommissural organ abnormalities, suggesting a possible role of PS1 in the regulation of cerebrospinal fluid homeostasis...
March 25, 2011: Brain Research
https://www.readbyqxmd.com/read/21029817/lack-of-effect-of-oral-beta-blocker-therapy-at-discharge-on-long-term-clinical-outcomes-of-st-segment-elevation-acute-myocardial-infarction-after-primary-percutaneous-coronary-intervention
#19
Neiko Ozasa, Takeshi Kimura, Takeshi Morimoto, Heigen Hou, Toshihiro Tamura, Satoshi Shizuta, Yoshihisa Nakagawa, Yutaka Furukawa, Yasuhiko Hayashi, Koichi Nakao, Masunori Matsuzaki, Masakiyo Nobuyoshi, Kazuaki Mitsudo
Beta-blocker therapy is recommended after ST-segment elevation acute myocardial infarction (STEMI) in current guidelines, although its efficacy in those patients who have undergone primary percutaneous coronary intervention (PCI) has not been adequately evaluated. Of 12,824 consecutive patients who underwent sirolimus-eluting stent implantation in the J-Cypher registry, we identified 910 patients who underwent PCI within 24 hours from onset of STEMI. Three-year outcomes were evaluated according to use of β blockers at hospital discharge (349 patients in β-blocker group and 561 patients in no-β-blocker group)...
November 1, 2010: American Journal of Cardiology
https://www.readbyqxmd.com/read/20948232/predictive-factors-associated-with-the-period-of-time-before-initiation-of-hemodialysis-in-ckd-stages-4-and-5
#20
COMPARATIVE STUDY
Masako Furukawa, Hiroaki Io, Mitsuo Tanimoto, Shinji Hagiwara, Satoshi Horikoshi, Yasuhiko Tomino
BACKGROUND: A majority of patients with chronic kidney disease (CKD) have cardiovascular disease at the initiation of dialysis therapy, suggesting that periodic echocardiographic examinations are important in such patients. The purpose of the present study was to evaluate the correlation between echocardiographic parameters and period of time before initiation of hemodialysis (iHD) in patients with CKD. METHODS: 140 patients with CKD stages 4 and 5 were enrolled...
2011: Nephron. Clinical Practice
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