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Satoshi Furukawa

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https://www.readbyqxmd.com/read/27925186/up-regulation-of-transient-receptor-potential-melastatin-6-channel-expression-by-tumor-necrosis-factor-%C3%AE-in-the-presence-of-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitor
#1
Chisa Furukawa, Naoko Fujii, Aya Manabe, Toshiyuki Matsunaga, Satoshi Endo, Hajime Hasegawa, Yoshinori Ito, Masahiko Yamaguchi, Yasuhiro Yamazaki, Akira Ikari
Anti-epidermal growth factor receptor (EGFR) drugs such as erlotinib and gefitinib cause a side effect of hypomagnesemia, but chemotherapy to treat this has not yet been developed. The transient receptor potential melastatin 6 (TRPM6) channel is involved in the reabsorption of Mg(2+) in the renal tubule. We reported previously that the expression of TRPM6 is up-regulated by epidermal growth factor (EGF) in renal tubular epithelial NRK-52E and HEK293 cells. EGF-induced elevation of TRPM6 expression was inhibited by erlotinib, gefitinib, and lapatinib...
December 7, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27849659/a-new-proposal-of-criteria-for-the-future-remnant-liver-volume-in-older-patients-undergoing-major-hepatectomy-for-biliary-tract-cancer
#2
Yoshihiro Watanabe, Satoshi Kuboki, Hiroaki Shimizu, Masayuki Ohtsuka, Hideyuki Yoshitomi, Katsunori Furukawa, Masaru Miyazaki
OBJECTIVE: To evaluate whether advanced age increases the risk of severe complications after major hepatectomy with bile duct resection (BDR) in patients with biliary tract cancer, and to establish new criteria for the percentage of the future remnant liver volume (%FLV) in older patients undergoing this operation. BACKGROUND: Advanced age is reported to inhibit liver regeneration and suppress immune function; however, little is known about the risk of aging in high-stress surgery, such as biliary tract surgery...
November 15, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27821915/histopathological-localization-of-cadmium-in-rat-placenta-by-la-icp-ms-analysis
#3
Yoshikazu Yamagishi, Satoshi Furukawa, Ayano Tanaka, Yoshiyuki Kobayashi, Akihiko Sugiyama
In order to clarify the histological localization of cadmium (Cd) in the placenta, we analyzed paraffin sections of placentas from rats with a single Cd exposure on gestation day 18 by the LA-ICP-MS imaging method compared with the histopathological changes. The placentas were sampled at 1 hour, 2 hours, 3 hours, 6 hours, and 24 hours after treatment. Histopathologically, the trophoblasts in the labyrinth zone of the Cd group showed swelling at 1 hour. At 2 and 3 hours, the trophoblasts showed swelling and vacuolar degeneration...
October 2016: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/27763495/auraptene-and-other-prenyloxyphenylpropanoids-suppress-microglial-activation-and-dopaminergic-neuronal-cell-death-in-a-lipopolysaccharide-induced-model-of-parkinson-s-disease
#4
Satoshi Okuyama, Tomoki Semba, Nobuki Toyoda, Francesco Epifano, Salvatore Genovese, Serena Fiorito, Vito Alessandro Taddeo, Atsushi Sawamoto, Mitsunari Nakajima, Yoshiko Furukawa
In patients with Parkinson's disease (PD), hyperactivated inflammation in the brain, particularly microglial hyperactivation in the substantia nigra (SN), is reported to be one of the triggers for the delayed loss of dopaminergic neurons and sequential motor functional impairments. We previously reported that (1) auraptene (AUR), a natural prenyloxycoumain, suppressed inflammatory responses including the hyperactivation of microglia in the ischemic brain and inflamed brain, thereby inhibiting neuronal cell death; (2) 7-isopentenyloxycoumarin (7-IP), another natural prenyloxycoumain, exerted anti-inflammatory and neuroprotective effects against excitotoxicity; and (3) 4'-geranyloxyferulic acid (GOFA), a natural prenyloxycinnamic acid, also exerted anti-inflammatory effects...
October 17, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27746415/2016-guidelines-for-the-management-of-thyroid-storm-from-the-japan-thyroid-association-and-japan-endocrine-society-first-edition
#5
Tetsurou Satoh, Osamu Isozaki, Atsushi Suzuki, Shu Wakino, Tadao Iburi, Kumiko Tsuboi, Naotetsu Kanamoto, Hajime Otani, Yasushi Furukawa, Satoshi Teramukai, Takashi Akamizu
Thyroid storm is an endocrine emergency which is characterized by multiple organ failure due to severe thyrotoxicosis, often associated with triggering illnesses. Early suspicion, prompt diagnosis and intensive treatment will improve survival in thyroid storm patients. Because of its rarity and high mortality, prospective intervention studies for the treatment of thyroid storm are difficult to carry out. We, the Japan Thyroid Association and Japan Endocrine Society taskforce committee, previously developed new diagnostic criteria and conducted nationwide surveys for thyroid storm in Japan...
October 15, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27744546/soy-isoflavone-intake-and-prevalence-of-depressive-symptoms-during-pregnancy-in-japan-baseline-data-from-the-kyushu-okinawa-maternal-and-child-health-study
#6
Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Shinya Furukawa, Masashi Arakawa
OBJECTIVE: Several observational studies and trials examined the relationship between isoflavones or soybeans and depressive symptoms among peri- and postmenopausal women. We cross-sectionally evaluated the associations between intake of soy products and isoflavones and depressive symptoms during pregnancy in Japan. METHODS: Study subjects were 1745 pregnant women. Dietary intake during the preceding month was assessed using a self-administered diet history questionnaire...
October 15, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27725532/optimal-follow-up-of-patients-with-viral-hepatitis-improves-the-detection-of-early-stage-hepatocellular-carcinoma-and-the-prognosis-of-survival
#7
Satoshi Oeda, Shinji Iwane, Mitsuhiro Takasaki, Naoko E Furukawa, Taiga Otsuka, Yuichiro Eguchi, Keizo Anzai
Objective To manage patients with viral hepatitis, it is important to screen for hepatitis, conduct a comprehensive examination if such screening is positive, administer antiviral treatment, and conduct surveillance for hepatocellular carcinoma (HCC). The proper execution of this strategy is expected to effectively reduce the number of deaths from viral hepatitis. Such an "optimal" follow-up for HCC surveillance is therefore important. This study aimed to determine the benefits of performing an optimal follow-up of patients with viral hepatitis...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27708857/risk-stratification-of-patients-with-chronic-heart-failure-using-cardiac-iodine-123-metaiodobenzylguanidine-imaging-incremental-prognostic-value-over-right-ventricular-ejection-fraction
#8
Shunsuke Tamaki, Takahisa Yamada, Takashi Morita, Yoshio Furukawa, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Takumi Kondo, Tsutomu Kawai, Satoshi Takahashi, Masashi Ishimi, Hideyuki Hakui, Tatsuhisa Ozaki, Yoshihiro Sato, Masahiro Seo, Yasushi Sakata, Masatake Fukunami
AIMS: Right ventricular (RV) systolic dysfunction has been shown to be an independent predictor of clinical outcome in patients with chronic heart failure (CHF), and cardiac metaiodobenzylguanidine (MIBG) imaging also provides prognostic information. We aimed to evaluate the long-term predictive value of combining RV systolic dysfunction and abnormal findings of cardiac MIBG imaging on outcome in CHF patients. METHODS AND RESULTS: We enrolled 63 CHF outpatients with left ventricular ejection fraction (EF) <40% in a prospective cohort study...
December 2015: ESC Heart Failure
https://www.readbyqxmd.com/read/27702570/rapid-tin-mediated-access-to-a-lysophosphatidylethanolamine-lpe-library-application-to-positional-lc-ms-analysis-for-hepatic-lpes-in-non-alcoholic-steatohepatitis-model-mice
#9
Takayuki Furukawa, Hirotoshi Fuda, Satoshi Miyanaga, Chinatsu Watanabe, Hitoshi Chiba, Shu-Ping Hui
Even though lysophospholipids have attracted much interest in recent years on account of their unique bioactivity, research related to lysophospholipids is usually hampered by problems associated with standard sample preparation and discrimination of regioisomers. Herein, we demonstrate a quick tin-chemistry-based synthetic route to lysophosphatidylethanolamines (LPEs) and its application in the positional analysis of hepatic LPEs in non-alcoholic steatohepatitis (NASH) model mice. We found that the preference of hepatic LPE regioisomer largely depends on the unsaturation of acyl chain in both control and NASH model mice...
October 1, 2016: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/27693417/phenotypes-associated-with-psychiatric-disorders-are-sex-specific-in-a-mutant-mouse-line
#10
Mitsunari Nakajima, Takashi Watanabe, Rui Aoki, Risei Shimizu, Satoshi Okuyama, Yoshiko Furukawa
Wnt1-Cre- and Wnt1-GAL4 double transgenic (dTg) mice are used to study neural crest cell lineages by utilizing either the Cre/loxP or the GAL4/UAS system. We have previously shown that these mice exhibit behavioral abnormalities that resemble certain behaviors of psychiatric disorders and histologic alterations in the cholinergic and glutamatergic systems in the brain. The objective of the current study was to extend the behavioral analyses in these mice and to determine whether there were any sex-specific differences in the prevalence or severity of these behaviors...
September 27, 2016: Brain Research
https://www.readbyqxmd.com/read/27646646/short-versus-prolonged-dual-antiplatelet-therapy-duration-after-bare-metal-stent-implantation-2-month-landmark-analysis-from-the-credo-kyoto-registry-cohort-2
#11
Masahiro Natsuaki, Takeshi Morimoto, Yutaka Furukawa, Yoshihisa Nakagawa, Kazushige Kadota, Kenji Ando, Hiroki Shiomi, Toshiaki Toyota, Hirotoshi Watanabe, Koh Ono, Satoshi Shizuta, Takashi Tamura, Moriaki Inoko, Tsukasa Inada, Manabu Shirotani, Mitsuo Matsuda, Takeshi Aoyama, Tomoya Onodera, Satoru Suwa, Teruki Takeda, Katsumi Inoue, Takeshi Kimura
One-month duration of dual antiplatelet therapy (DAPT) has widely been adopted after bare-metal stent (BMS) implantation in the real clinical practice. However, it has not been adequately addressed yet whether DAPT for only 1-month could provide sufficient protection from ischemic events beyond 1-month after BMS implantation. We assessed the effects of short DAPT relative to prolonged DAPT on clinical outcomes with the landmark analysis at 2 month after BMS implantation. Among 13,058 consecutive patients enrolled in the CREDO-Kyoto registry cohort-2, this study population consisted of 4905 patients treated with BMS only in whom the information on the status of antiplatelet therapy was available at 2 month after stent implantation [single-antiplatelet therapy (SAPT) group: N = 2575 (acute myocardial infarction (AMI): N = 1257, and non-AMI: N = 1318), and DAPT group: N = 2330 (AMI: N = 1304, and non-AMI: N = 1026)]...
September 19, 2016: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/27632910/milk-intake-during-pregnancy-is-inversely-associated-with-the-risk-of-postpartum-depressive-symptoms-in-japan-the-kyushu-okinawa-maternal-and-child-health-study
#12
Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Shinya Furukawa, Masashi Arakawa
Only one epidemiologic study has investigated the association between dairy product intake during pregnancy and postpartum depressive symptoms. Epidemiologic evidence on the relationships between calcium and vitamin D intake during pregnancy and postpartum depressive symptoms is also lacking. The present prospective study examined these issues in Japan. Study subjects were 1319 women. During pregnancy, dietary intake during the preceding month was assessed using a self-administered diet history questionnaire in the baseline survey...
September 2016: Nutrition Research
https://www.readbyqxmd.com/read/27590487/c1q-tnf-related-protein-3-expression-and-effects-on-adipocyte-differentiation-of-3t3-l1-cells
#13
Hiroki Nishimoto, Akihiro Yamamoto, Souhei Furukawa, Satoshi Wakisaka, Takashi Maeda
Adipose tissue-derived adipokines influence a number of organs critical for energy homeostasis and metabolism. One of the most extensively studied adipokines is adiponectin, which exerts anti-diabetic, anti-inflammatory and anti-atherogenic functions on various cell types. CTRP3, a paralog of adiponectin, is a member of the C1q and tumor necrosis factor-related protein (CTRP) superfamily. CTRP3 reduces hepatic triglyceride levels in diet-induced obese (DIO) mice. However, the physiological role of CTRP3 in adipocytes is largely unknown...
September 3, 2016: Cell Biology International
https://www.readbyqxmd.com/read/27559242/effect-of-methotrexate-exposure-at-middle-gestation-on-the-inner-plate-of-the-ocular-cup-and-lens-in-the-rat-fetus
#14
Cheng Zhe Zu, Masato Kuroki, Ayano Hirako, Takashi Takeuchi, Satoshi Furukawa, Akihiko Sugiyama
Pregnant rats were treated intraperitoneally with a single dose of methotrexate (MTX) 90 mg/kg on gestation day (GD) 13, and fetal eyeballs were examined time-dependently from GD 13.5 to 15.5. Throughout the experimental period, the inner plate of the ocular cup in the MTX group was significantly thinner than that in the control group. In the inner plate of the ocular cup on GD 15 and 15.5, whereas a developed ganglion cell layer was observed in the control group, the ganglion cell layer in the MTX group was undeveloped and indistinguishable...
July 2016: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/27512087/very-long-term-10-to-14-year-outcomes-after-percutaneous-coronary-intervention-versus-coronary-artery-bypass-grafting-for-multivessel-coronary-artery-disease-in-the-bare-metal-stent-era
#15
Hiroki Shiomi, Kyohei Yamaji, Takeshi Morimoto, Satoshi Shizuta, Kenji Nakatsuma, Hirooki Higami, Yutaka Furukawa, Yoshihisa Nakagawa, Kazushige Kadota, Kenji Ando, Ryuzo Sakata, Hitoshi Okabayashi, Michiya Hanyu, Mitsuomi Shimamoto, Noboru Nishiwaki, Tatsuhiko Komiya, Takeshi Kimura
BACKGROUND: Many of the previous randomized trials comparing percutaneous coronary intervention (PCI) with coronary artery bypass grafting (CABG) in patients with multivessel coronary artery disease reported equivalent or better survival with CABG as compared with PCI at 5-year follow-up. However, 5-year follow-up might be too short to evaluate the true differences in long-term clinical outcomes between PCI and CABG. METHODS AND RESULTS: Among 8934 patients enrolled in the extended 10- to 14-year follow-up study of the CREDO-Kyoto registry cohort-1 (Coronary Revascularization Demonstrating Outcome study in Kyoto) conducted in the bare-metal stent era, 5152 (PCI: n=3490 and CABG: n=1662) patients had multivessel coronary artery disease without left main disease...
August 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27489535/learning-and-memory-deficits-in-male-adult-mice-treated-with-a-benzodiazepine-sleep-inducing-drug-during-the-juvenile-period
#16
Yusuke Furukawa, Kentaro Tanemura, Katsuhide Igarashi, Maky Ideta-Otsuka, Ken-Ichi Aisaki, Satoshi Kitajima, Masanobu Kitagawa, Jun Kanno
Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the mammalian central nervous system, is also known to be important for brain development. Therefore, disturbances of GABA receptor (GABA-R) mediated signaling (GABA-R signal) during brain development may influence normal brain maturation and cause late-onset brain malfunctions. In this study, we examined whether the stimulation of the GABA-R signal during brain development induces late-onset adverse effects on the brain in adult male mice...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27451128/activation-of-peroxisome-proliferator-activated-receptor-gamma-inhibits-tumor-growth-by-negatively-regulating-nuclear-factor-%C3%AE%C2%BAb-activation-in-patients-with-hepatocellular-carcinoma
#17
Hiroyuki Nojima, Satoshi Kuboki, Kimio Shinoda, Hiroaki Shimizu, Masayuki Ohtsuka, Atsushi Kato, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Masaru Miyazaki
BACKGROUND: The prognosis of advanced hepatocellular carcinoma (HCC) is poor because of its rapid progression. Peroxisome proliferator-activated receptor-gamma (PPARγ) is known to inhibit tumor growth in vitro; however, the behavior of PPARγ in clinical cases of HCC remains uncertain. METHODS: Surgical specimens were collected from 104 HCC patients. The anti-neoplastic effects of PPARγ were evaluated. RESULTS: PPARγ and its ligand expression were increased in some cases of HCC...
September 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27414399/enuresis-and-hyperactivity-inattention-in-early-adolescence-findings-from-a-population-based-survey-in-tokyo-tokyo-early-adolescence-survey
#18
Sho Kanata, Shinsuke Koike, Shuntaro Ando, Atsushi Nishida, Satoshi Usami, Syudo Yamasaki, Yuko Morimoto, Rie Toriyama, Shinya Fujikawa, Noriko Sugimoto, Tsukasa Sasaki, Toshiaki A Furukawa, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai
BACKGROUND: Enuresis (9% at age 9.5) negatively affects children's psychosocial status. Clinically-diagnosed enuresis (2% at the age) is associated with hyperactivity-inattention, and common neural bases have been postulated to underlie this association. It is, however, unclear whether this association is applicable to enuresis overall among the general population of early adolescents when considered comorbid behavioral problems. We aimed to examine whether enuresis correlates with hyperactivity-inattention after controlling for the effects of other behavioral problems...
2016: PloS One
https://www.readbyqxmd.com/read/27364298/determination-of-both-fetus-and-mother-s-blood-type-from-an-autopsy-case-immersed-in-formalin-for-over-50-years
#19
Akari Takaya Uno, Satomu Morita, Satoshi Furukawa, Katsuji Nishi, Masahito Hitosugi
A female fetus which had been immersed in formalin for more than 50 years was found in Japan. Because no liquid blood could be obtained, we tried to use immunohistochemistry (IHC) methods to tissue samples obtained at autopsy to identify both the fetal and mother's blood type. We detected B antigens on endothelial cells in paraffin sections of the fetal organs. Furthermore, we observed both anti-A- and anti-B-positive red blood cells in the intervillous space, which is indicative of the mother's blood type...
July 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27341422/mechanisms-of-behavioral-activation-for-late-adolescents-positive-reinforcement-mediate-the-relationship-between-activation-and-depressive-symptoms-from-pre-treatment-to-post-treatment
#20
Koki Takagaki, Yasumasa Okamoto, Ran Jinnin, Asako Mori, Yoshiko Nishiyama, Takanao Yamamura, Satoshi Yokoyama, Syouichi Shiota, Yuri Okamoto, Yoshie Miyake, Akiko Ogata, Haruki Shimoda, Norito Kawakami, Toshi A Furukawa, Shigeto Yamawaki
BACKGROUND: It is suggested that there is some support for notion that frequency of activity can lead to improved mood in behavioral activation, but this research is relatively imprecise. We investigated whether positive reinforcement mediates the relationship between activation and alleviation of depressive symptoms METHODS: Late adolescents with sub-threshold depressive symptoms participated in the study. We conducted an intervention using behavioral activation with the participants...
November 1, 2016: Journal of Affective Disorders
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