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Satoshi Furukawa

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https://www.readbyqxmd.com/read/29331986/sex-differences-in-impact-of-coronary-artery-calcification-to-predict-coronary-artery-disease
#1
Yoko M Nakao, Yoshihiro Miyamoto, Masahiro Higashi, Teruo Noguchi, Mitsuru Ohishi, Isao Kubota, Hiroyuki Tsutsui, Tomohiro Kawasaki, Yutaka Furukawa, Michihiro Yoshimura, Hideaki Morita, Kunihiro Nishimura, Akiko Kada, Yoichi Goto, Tomonori Okamura, Chuwa Tei, Hitonobu Tomoike, Hiroaki Naito, Satoshi Yasuda
OBJECTIVE: To assess sex-specific differences regarding use of conventional risks and coronary artery calcification (CAC) to detect coronary artery disease (CAD) using coronary CT angiography (CCTA). METHODS: The Nationwide Gender-specific Atherosclerosis Determinants Estimation and Ischemic Cardiovascular Disease Prospective Cohort study is a prospective, multicentre, nationwide cohort study. Candidates with suspected CAD aged 50-74 years enrolled from 2008 to 2012...
January 13, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29320574/acceleration-of-small-bowel-motility-after-oral-administration-of-dai-kenchu-to-tj-100-assessed-by-cine-magnetic-resonance-imaging
#2
Akitoshi Inoue, Akira Furukawa, Hiroshi Yamamoto, Shinichi Ohta, Nguyen Dai Hung Linh, Tulyeubai Syerikjan, Sachiko Kaida, Tsuyoshi Yamaguchi, Satoshi Murata, Toru Obata, Masaji Tani, Kiyoshi Murata
Dai-kenchu-to (TJ-100) is an herbal medicine used to shorten the duration of intestinal transit by accelerating intestinal movement. However, intestinal movement in itself has not been evaluated in healthy volunteers using radiography, fluoroscopy, and radioisotopes because of exposure to ionizing radiation. The purpose of this study was to evaluate the effect of TJ-100 on intestinal motility using cinematic magnetic resonance imaging (cine MRI) with a steady-state free precession sequence. Ten healthy male volunteers received 5 g of either TJ-100 or lactose without disclosure of the identity of the substance...
2018: PloS One
https://www.readbyqxmd.com/read/29246259/macrophages-in-trigeminal-ganglion-contribute-to-ectopic-mechanical-hypersensitivity-following-inferior-alveolar-nerve-injury-in-rats
#3
Dulguun Batbold, Masamichi Shinoda, Kuniya Honda, Akihiko Furukawa, Momoko Koizumi, Ryuta Akasaka, Satoshi Yamaguchi, Koichi Iwata
BACKGROUND: Accidental mandibular nerve injury may occur during tooth extraction or implant procedures, causing ectopic orofacial pain. The exact mechanisms underlying ectopic orofacial pain following mandibular nerve injury is still unknown. Here, we investigated the role of macrophages and tumor necrosis factor alpha (TNFα) in the trigeminal ganglion (TG) in ectopic orofacial pain following inferior alveolar nerve transection (IANX). METHODS: IANX was performed and the mechanical head-withdrawal threshold (MHWT) in the whisker pad skin ipsilateral to IANX was measured for 15 days...
December 16, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29234896/correction-to-multicenter-phase-ii-study-of-trastuzumab-plus-s-1-alone-in-elderly-patients-with-her2-positive-advanced-gastric-cancer-jaccro-gc%C3%A2-06
#4
Yutaka Kimura, Masashi Fujii, Toshiki Masuishi, Kazuhiro Nishikawa, Chikara Kunisaki, Satoshi Matsusaka, Yoshihiko Segawa, Masato Nakamura, Kinro Sasaki, Narutoshi Nagao, Yukimasa Hatachi, Yasuhiro Yuasa, Shinya Asami, Masahiro Takeuchi, Hiroshi Furukawa, Toshifusa Nakajima
The correct name of the twelfth author should be ''Yasuhiro Yuasa", and not ''Yasuhiko Yuasa'' as given in the original publication of the article.
December 12, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29164423/successful-radical-surgical-resection-of-initially-unresectable-intrahepatic-cholangiocarcinoma-by-downsizing-chemotherapy-with-gemcitabine-plus-cisplatin-a-case-report
#5
Ryosuke Takayanagi, Shigetsugu Takano, Kensuke Sugiura, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Atsushi Kato, Masaru Miyazaki, Masayuki Ohtsuka
BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is a subtype of biliary tract cancer (BTC). Recently, downsizing chemotherapy has been applied to initially unresectable BTCs, including ICC. CASE PRESENTATION: We report a case of liver resection in a 23-year-old woman who was diagnosed with initially unresectable ICC attached to the inferior vena cava, with portal vein (PV) cavernous transformation. Positron emission tomography (PET) showed fluorodeoxyglucose (FDG) uptake in the para-aortic lymph nodes...
November 21, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29146627/single-session-versus-staged-procedures-for-elective-multivessel-percutaneous-coronary-intervention
#6
Toshiaki Toyota, Takeshi Morimoto, Hiroki Shiomi, Kyohei Yamaji, Kenji Ando, Koh Ono, Satoshi Shizuta, Naritatsu Saito, Takao Kato, Shuichiro Kaji, Yutaka Furukawa, Yoshihisa Nakagawa, Kazushige Kadota, Minoru Horie, Takeshi Kimura
OBJECTIVES: To clarify the effect of single-session multivessel percutaneous coronary intervention (PCI) strategy relative to the staged multivessel strategy on clinical outcomes in patients with stable coronary artery disease (CAD) or non-ST-elevation acute coronary syndrome. METHODS: In the Coronary REvascularisation Demonstrating Outcome Study in Kyoto PCI/coronary artery bypass grafting registry cohort-2, there were 2018 patients who underwent elective multivessel PCI...
November 16, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29142173/effect-of-dibutyltin-on-placental-and-fetal-toxicity-in-rat
#7
Satoshi Furukawa, Naho Tsuji, Yoshiyuki Kobayashi, Yoshikazu Yamagishi, Seigo Hayashi, Masayoshi Abe, Yusuke Kuroda, Masayuki Kimura, Chisato Hayakawa, Akihiko Sugiyama
In order to elucidate the effect of chorioallantoic and yolk sac placenta on the embryonic/fetal toxicity in dibutyltin dichloride (DBTCl)-exposed rats, we examined the histopathological changes and the tissue distribution of dibutyltin in the placentas and embryos. DBTCl was orally administered to the groups at doses of 0 mg/kg during gestation days (GD)s 7-9 (control group) and 20 mg/kg during GDs 7-9 (GD7-9 treated group), and GDs 10-12 (GD10-12 treated group). The total fetal mortality was increased, and malformations characterized by craniofacial dysmorphism were detected in the GD7-9 treated group...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29130985/heptamethoxyflavone-reduces-phosphodiesterase-activity-and-t-cell-growth-in-vitro
#8
Yui Hamada, Mitsunari Nakajima, Kazuna Tsuzuki, Yoshiaki Amakura, Morio Yoshimura, Satoshi Okuyama, Yoshiko Furukawa
In a previous study, we reported that interleukin-4 production was reduced in spleen cells of mice administered 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), which is a polymethoxyflavone found at high concentrations in the peel of various citrus fruits. In this study, we investigated the function of HMF on the growth of T cells cultured from the spleens of mice. HMF decreased the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) by anti-CD3/CD28 antibody-stimulated mouse spleen cells...
November 8, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29098501/rationale-and-design-of-low-dose-administration-of-carperitide-for-acute-heart-failure-lascar-ahf
#9
Toshiyuki Nagai, Yasuyuki Honda, Hiroki Nakano, Satoshi Honda, Naotsugu Iwakami, Atsushi Mizuno, Nobuyuki Komiyama, Takafumi Yamane, Yutaka Furukawa, Tadayoshi Miyagi, Syuzo Nishihara, Nobuhiro Tanaka, Taichi Adachi, Toshimitsu Hamasaki, Yasuhide Asaumi, Yoshio Tahara, Takeshi Aiba, Yasuo Sugano, Hideaki Kanzaki, Teruo Noguchi, Kengo Kusano, Satoshi Yasuda, Hisao Ogawa, Toshihisa Anzai
BACKGROUNDS: Despite current therapies, acute heart failure (AHF) remains a major public health burden with high rates of in-hospital and post-discharge morbidity and mortality. Carperitide is a recombinantly produced intravenous formulation of human atrial natriuretic peptide that promotes vasodilation with increased salt and water excretion, which leads to reduction of cardiac filling pressures. A previous open-label randomized controlled study showed that carperitide improved long-term cardiovascular mortality and heart failure (HF) hospitalization for patients with AHF, when adding to standard therapy...
November 2, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29097846/effects-of-cadmium-exposure-on-iberian-ribbed-newt-pleurodeles-waltl-testes
#10
Ayano Hirako, Yuki Takeoka, Toshinori Hayashi, Takashi Takeuchi, Satoshi Furukawa, Akihiko Sugiyama
To characterize the histomorphologic effects of cadmium on adult newt testes, male Iberian ribbed newts (6 months post-hatching) were intraperitoneally exposed to a single dose of 50 mg/kg of cadmium, with histologic analysis of the testes at 24, 48, 72, and 96 h. Beginning 24 h after cadmium exposure, apoptosis of spermatogonia and spermatocytes was observed, and congestion was observed in the interstitial vessels of the testes. Throughout the experimental period, the rates of pyknotic cells and TUNEL and cleaved caspase-3 positivity were significantly higher in the spermatogonia and spermatocytes of cadmium-treated newts compared with control newts...
October 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29097838/effects-of-methotrexate-exposure-on-medaka-oryzias-latipes-testes
#11
Ayano Hirako, Yuki Takeoka, Satoshi Furukawa, Akihiko Sugiyama
For the purpose of clarifying the histopathological effects of methotrexate (MTX) on medaka testes, wild-type and homogenic p53-deficient male medaka at 4 to 6 months post-hatching were exposed to 0.25 mg/ml of MTX for 96 h with histopathological examination of testes at 24, 48, 72 and 96 h. At 72 and 96 h after the start of MTX exposure, numerous apoptotic cells were observed in the spermatogonia and spermatocytes, and the pyknotic cell rate and the TUNEL-positive and cleaved caspase-3-positive rates in the spermatogonia and spermatocytes of MTX-treated wild type medaka were higher compared with those in the control wild-type medaka...
October 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/29080917/immunohistochemical-analysis-on-aquaporin-1-and-aquaporin-3-in-skin-wounds-from-the-aspects-of-wound-age-determination
#12
Yuko Ishida, Yumi Kuninaka, Fukumi Furukawa, Akihiko Kimura, Mizuho Nosaka, Mie Fukami, Hiroki Yamamoto, Takashi Kato, Emi Shimada, Satoshi Hata, Tatsunori Takayasu, Wolfgang Eisenmenger, Toshikazu Kondo
Immunohistochemical investigation of aquaporin (AQP)1 and AQP3 was performed in human skin wounds obtained from forensic autopsy cases. A total of 55 human skin wounds of different postinfliction intervals were collected as follows: group I, 0-3 days (n = 16); II, 4-7 days (n = 11); III, 9-14 days (n = 16); and IV, 17-21 days (n = 12). In uninjured skin samples, AQP1 and AQP3 could be slightly detected in dermal vessels and keratinocytes, respectively. The percentage of AQP1(+) vessels and the number of AQP3(+) keratinocytes were apparently elevated in accordance with wound ages...
October 28, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29077749/a-practical-approach-to-pancreatic-cancer-immunotherapy-using-resected-tumor-lysate-vaccines-processed-to-express-%C3%AE-gal-epitopes
#13
Kenta Furukawa, Masahiro Tanemura, Eiji Miyoshi, Hidetoshi Eguchi, Hiroaki Nagano, Katsuyoshi Matsunami, Satoshi Nagaoka, Daisaku Yamada, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Koichi Kawamoto, Kunihito Goto, Kiyomi Taniyama, Masaki Mori, Yuichiro Doki
OBJECTIVES: Single-agent immunotherapy is ineffective against poorly immunogenic cancers, including pancreatic ductal adenocarcinoma (PDAC). The aims of this study were to demonstrate the feasibility of production of novel autologous tumor lysate vaccines from resected PDAC tumors, and verify vaccine safety and efficacy. METHODS: Fresh surgically resected tumors obtained from human patients were processed to enzymatically synthesize α-gal epitopes on the carbohydrate chains of membrane glycoproteins...
2017: PloS One
https://www.readbyqxmd.com/read/29070780/no-change-in-the-prevalence-of-latent-prostate-cancer-over-the-last-10-years-a-forensic-autopsy-study-in-japan
#14
Masahito Hitosugi, Kenichi Mukaisho, Masahito Kido, Shuichi Kamimura, Satoshi Furukawa, Hiroyuki Sugihara
Although the morbidity rate of prostate cancer has increased with 2.3 times in these 10 years in Japan, little is known about the changes in the prevalence of latent prostate cancer. To understand changes in the prevalence of latent prostate cancer, a retrospective analysis was performed. Forensic autopsy findings from Tochigi Prefecture between September 2012 and February 2014 were collected. Two cross sections, from the base and apex of the prostate, were examined histopathologically. The prevalence of latent prostate cancer was compared with findings from forensic autopsies performed between August 2002 and July 2005 in the same region...
2017: Biomedical Research
https://www.readbyqxmd.com/read/29066679/-iv-distal-pancreatectomy-with-celiac-axis-resection-dp-car-for-locally-advanced-pancreatic-cancer-with-celiac-artery-invasion
#15
Hideyuki Yoshitomi, Nozomu Sakai, Atsuhiko Ueda, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Daisuke Suzuki, Shingo Kagawa, Hiroyuki Nojima, Takashi Mishima, Masaru Miyazaki, Masayuki Ohtsuka
No abstract text is available yet for this article.
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29023414/3-5-6-7-8-3-4-heptamethoxyflavone-ameliorates-depressive-like-behavior-and-hippocampal-neurochemical-changes-in-chronic-unpredictable-mild-stressed-mice-by-regulating-the-brain-derived-neurotrophic-factor-requirement-for-erk-activation
#16
Atsushi Sawamoto, Satoshi Okuyama, Yoshiaki Amakura, Morio Yoshimura, Takashi Yamada, Hidehiko Yokogoshi, Mitsunari Nakajima, Yoshiko Furukawa
We previously reported that the subcutaneous administration of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), a citrus polymethoxyflavone, attenuated depressive-like behavior and increased the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of a corticosterone-induced depression-like mouse model. We herein demonstrated that (1) HMF was detectable in the brain 10 and 30 min after its oral administration, (2) orally administered HMF improved chronic unpredictable mild stress (CUMS)-induced pathological conditions, including body weight loss and depressive-like behavior, and CUMS-induced neurochemical changes, such as reduction in BDNF expression, decrease in neurogenesis, and decreased level of phosphorylated calcium-calmodulin-dependent protein kinase II in the hippocampus, and (3) these effects of HMF were inhibited by the pre-administration of U0126, a mitogen-activated protein (MAP) kinase inhibitor...
October 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29021239/an-rna-binding-protein-qki5-regulates-embryonic-neural-stem-cells-through-pre-mrna-processing-in-cell-adhesion-signaling
#17
Yoshika Hayakawa-Yano, Satoshi Suyama, Masahiro Nogami, Masato Yugami, Ikuko Koya, Takako Furukawa, Li Zhou, Manabu Abe, Kenji Sakimura, Hirohide Takebayashi, Atsushi Nakanishi, Hideyuki Okano, Masato Yano
Cell type-specific transcriptomes are enabled by the action of multiple regulators, which are frequently expressed within restricted tissue regions. In the present study, we identify one such regulator, Quaking 5 (Qki5), as an RNA-binding protein (RNABP) that is expressed in early embryonic neural stem cells and subsequently down-regulated during neurogenesis. mRNA sequencing analysis in neural stem cell culture indicates that Qki proteins play supporting roles in the neural stem cell transcriptome and various forms of mRNA processing that may result from regionally restricted expression and subcellular localization...
September 15, 2017: Genes & Development
https://www.readbyqxmd.com/read/28993595/optimization-of-analytical-conditions-for-a-rapid-determination-of-aniline-in-environmental-water-by-liquid-chromatography-tandem-mass-spectrometry
#18
Koji Furukawa, Makoto Hashimoto, Satoshi Kaneco
A rapid determination of aniline in environmental water was examined based on liquid chromatography/tandem mass spectrometry (LC/MS/MS). Environmental water samples were diluted 20-fold with Mill-Q water and measured by LC/MS/MS after adding a surrogate substance (aniline-d5). In the results of the present study, the calibration curve of aniline showed good linearity in the range of 0.05 - 2.0 μg/L. Since the RSD (repeatability) by measuring repeatedly an aniline standard solution (0.05 μg/L, n = 7) was 3...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28956012/flecainide-ameliorates-arrhythmogenicity-through-ncx-flux-in-andersen-tawil-syndrome-ips-cell-derived-cardiomyocytes
#19
Yusuke Kuroda, Shinsuke Yuasa, Yasuhide Watanabe, Shogo Ito, Toru Egashira, Tomohisa Seki, Tetsuhisa Hattori, Seiko Ohno, Masaki Kodaira, Tomoyuki Suzuki, Hisayuki Hashimoto, Shinichiro Okata, Atsushi Tanaka, Yoshiyasu Aizawa, Mitsushige Murata, Takeshi Aiba, Naomasa Makita, Tetsushi Furukawa, Wataru Shimizu, Itsuo Kodama, Satoshi Ogawa, Norito Kokubun, Hitoshi Horigome, Minoru Horie, Kaichiro Kamiya, Keiichi Fukuda
Andersen-Tawil syndrome (ATS) is a rare inherited channelopathy. The cardiac phenotype in ATS is typified by a prominent U wave and ventricular arrhythmia. An effective treatment for this disease remains to be established. We reprogrammed somatic cells from three ATS patients to generate induced pluripotent stem cells (iPSCs). Multi-electrode arrays (MEAs) were used to record extracellular electrograms of iPSC-derived cardiomyocytes, revealing strong arrhythmic events in the ATS-iPSC-derived cardiomyocytes...
March 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28939904/up-regulation-of-claudin-2-expression-by-aldosterone-in-colonic-epithelial-cells-of-mice-fed-with-nacl-depleted-diets
#20
Chisa Furukawa, Noriko Ishizuka, Hisayoshi Hayashi, Naoko Fujii, Aya Manabe, Yoshiaki Tabuchi, Toshiyuki Matsunaga, Satoshi Endo, Akira Ikari
Dietary NaCl depletion increases Na(+) absorption and K(+) secretion in the colon, but the mechanisms are not fully understood. In mice fed with NaCl-depleted diets, the expression of claudin-2 and -7 increased compared to those in control mice. Aldosterone (ALD) concentration was also increased. We examined the regulatory mechanism of claudin expression by ALD using the murine colonic epithelial MCE301 cells. ALD dose-dependently increased claudin-2 expression without affecting the expression of claudin-4, -7, -8, and -15...
September 22, 2017: Scientific Reports
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