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Satoshi Furukawa

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https://www.readbyqxmd.com/read/29749431/expression-of-annexin-ii-and-stromal-tenascin-c-promotes-epithelial-to-mesenchymal-transition-and-correlates-with-distant-metastasis-in-pancreatic-cancer
#1
Naoko Yoneura, Shigetsugu Takano, Hideyuki Yoshitomi, Yasuyuki Nakata, Reiri Shimazaki, Shingo Kagawa, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Masaru Miyazaki, Masayuki Ohtsuka
The interaction between cancer cells and stromal components contributes to cancer invasion and metastasis in pancreatic ductal adenocarcinoma (PDAC). The present study investigated the role of the correlation between annexin II (ANX2) and stromal tenascin C (TNC) with the progression of PDAC. The functions of the expression ANX2 and TNC were assessed in in vitro experiments using mouse and human PDAC cells, and the clinical effect was analyzed using immunohistochemistry with surgically resected PDAC tissues...
May 2, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29732953/suppressive-effects-of-the-peel-of-citrus-kawachiensis-kawachi-bankan-on-astroglial-activation-tau-phosphorylation-and-inhibition-of-neurogenesis-in-the-hippocampus-of-type-2-diabetic-db-db-mice
#2
Satoshi Okuyama, Wakana Shinoka, Kumi Nakamura, Maho Kotani, Atsushi Sawamoto, Kuniaki Sugawara, Masahiko Sudo, Mitsunari Nakajima, Yoshiko Furukawa
We previously reported that the dried peel powder of Citrus kawachiensis exerted anti-inflammatory effects in the brain in several animal models. Hyperglycemia induces inflammation and oxidative stress and causes massive damage in the brain; therefore, we herein examined the anti-inflammatory and other effects of the dried peel powder of C. kawachiensis in the streptozotocin-induced hyperglycemia mice model and in the type 2 diabetic db/db mice model. The C. kawachiensis administration inhibited microglial activation in the hippocampus in the streptozotocin-injected mice...
May 6, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29721779/novel-treatment-strategy-with-radiofrequency-ablation-and-surgery-for-pregnant-patients-with-hepatocellular-carcinoma-a-case-report
#3
Megumi Matsuo, Katsunori Furukawa, Hiroaki Shimizu, Hideyuki Yoshitomi, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Daisuke Suzuki, Nozomu Sakai, Shingo Kagawa, Hiroyuki Nojima, Masayuki Ohsuka
BACKGROUND: Hepatocellular carcinoma (HCC) during pregnancy is rare, with a poor prognosis. Recently, however, increasing resection rates have improved survival rate. Currently, various surgeries are safely performed after the second trimester and termination of pregnancy is not always necessary. However, surgery is sometimes limited by gestational age or the patient's will. When patients with HCC refuse surgery during pregnancy, we face specific problems with respect to curability and fetal life...
May 2, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29618282/neuroprotective-effect-of-citrus-kawachiensis-kawachi-bankan-peels-a-rich-source-of-naringin-against-global-cerebral-ischemia-reperfusion-injury-in-mice
#4
Satoshi Okuyama, Kana Yamamoto, Hirotomo Mori, Atsushi Sawamoto, Yoshiaki Amakura, Morio Yoshimura, Arisa Tamanaha, Yuu Ohkubo, Kuniaki Sugawara, Masahiko Sudo, Mitsunari Nakajima, Yoshiko Furukawa
Cerebral ischemia/reperfusion is known to induce the generation of reactive oxygen species and inflammatory responses. Numerous studies have demonstrated that naringin (NGIN) has anti-oxidant and anti-inflammatory properties. We previously reported that Citrus kawachiensis contains a large quantity of NGIN in its peel. In the present study, we orally (p.o.) administered dried peel powder of C. kawachiensis to mice of a transient global ischemia model and found in the hippocampus region that it 1) suppressed neuronal cell death, 2) reversed the reduction in the level of phosphorylated calcium-calmodulin-dependent protein kinase II, 3) had the tendency to reverse the reduction in the level of glutathione, and 4) blocked excessive activation of microglia and astrocytes...
April 4, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29600294/characteristics-of-glucose-metabolism-in-underweight-japanese-women
#5
Yuki Someya, Yoshifumi Tamura, Ruriko Suzuki, Hideyoshi Kaga, Satoshi Kadowaki, Daisuke Sugimoto, Saori Kakehi, Takashi Funayama, Yasuhiko Furukawa, Kageumi Takeno, Junko Sato, Akio Kanazawa, Ryuzo Kawamori, Hirotaka Watada
Context: Japanese women have substantially lower body mass index (BMI) than women in other developed countries. The BMI of Japanese women has steadily decreased over time. However, glucose metabolism in underweight Japanese women has not been fully characterized. Objective: The aim of this study was to investigate glucose metabolism and the physical characteristics of underweight Japanese women. Design and Participants: We recruited 31 young (20 to 29 years of age) and 30 postmenopausal (50 to 65 years of age) underweight women...
March 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29590622/lrit1-a-retinal-transmembrane-protein-regulates-selective-synapse-formation-in-cone-photoreceptor-cells-and-visual-acuity
#6
Akiko Ueno, Yoshihiro Omori, Yuko Sugita, Satoshi Watanabe, Taro Chaya, Takashi Kozuka, Tetsuo Kon, Satoyo Yoshida, Kenji Matsushita, Ryusuke Kuwahara, Naoko Kajimura, Yasushi Okada, Takahisa Furukawa
In the vertebrate retina, cone photoreceptors play crucial roles in photopic vision by transmitting light-evoked signals to ON- and/or OFF-bipolar cells. However, the mechanisms underlying selective synapse formation in the cone photoreceptor pathway remain poorly understood. Here, we found that Lrit1, a leucine-rich transmembrane protein, localizes to the photoreceptor synaptic terminal and regulates the synaptic connection between cone photoreceptors and cone ON-bipolar cells. Lrit1-deficient retinas exhibit an aberrant morphology of cone photoreceptor pedicles, as well as an impairment of signal transmission from cone photoreceptors to cone ON-bipolar cells...
March 27, 2018: Cell Reports
https://www.readbyqxmd.com/read/29588152/generation-and-characterization-of-a-potent-fully-human-monoclonal-antibody-against-the-interleukin-23-receptor
#7
Haruna Sasaki-Iwaoka, Makoto Ohori, Akira Imasato, Katsunari Taguchi, Kyoko Minoura, Tetsu Saito, Kiyoshi Kushima, Emiko Imamura, Satoshi Kubo, Shigetada Furukawa, Tatsuaki Morokata
Interleukin (IL)-12 and IL-23 share a common subunit (p40) and function in T-helper (Th) 1 and Th17 immunity, respectively. Anti-IL-12/23p40 and specific anti-IL-23 antibodies are currently in clinical use for psoriasis and undergoing trials for autoimmune diseases. Since expression levels of the IL-23 receptor are likely to be much lower than those of IL-23, an anti-IL-23 receptor antibody might offer greater promise in inhibiting the IL-23-IL-17 pathways involved in inflammatory disorders. To our knowledge, no anti-IL-23 receptor antibody has been trialed in clinical studies to date...
March 24, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29587553/a-fatality-following-difluoroethane-exposure-with-blood-and-tissue-concentrations
#8
Genta Yamada, Marin Takaso, Masateru Kane, Satoshi Furukawa, Masahito Hitosugi
No abstract text is available yet for this article.
March 28, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29556211/deficits-in-visuo-motor-temporal-integration-impacts-manual-dexterity-in-probable-developmental-coordination-disorder
#9
Satoshi Nobusako, Ayami Sakai, Taeko Tsujimoto, Takashi Shuto, Yuki Nishi, Daiki Asano, Emi Furukawa, Takuro Zama, Michihiro Osumi, Sotaro Shimada, Shu Morioka, Akio Nakai
The neurological basis of developmental coordination disorder (DCD) is thought to be deficits in the internal model and mirror-neuron system (MNS) in the parietal lobe and cerebellum. However, it is not clear if the visuo-motor temporal integration in the internal model and automatic-imitation function in the MNS differs between children with DCD and those with typical development (TD). The current study aimed to investigate these differences. Using the manual dexterity test of the Movement Assessment Battery for Children (second edition), the participants were either assigned to the probable DCD (pDCD) group or TD group...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29508236/mortality-impact-of-post-discharge-myocardial-infarction-size-after-percutaneous-coronary-intervention-a-patient-level-pooled-analysis-from-the-4-large-scale-japanese-studies
#10
Hirotoshi Watanabe, Takeshi Morimoto, Hiroki Shiomi, Yusuke Yoshikawa, Takao Kato, Naritatsu Saito, Satoshi Shizuta, Koh Ono, Kyohei Yamaji, Kenji Ando, Shuichiro Kaji, Yutaka Furukawa, Masaharu Akao, Tetsuya Ishikawa, Takashi Tamura, Yoshito Yamamoto, Toshiya Muramatsu, Satoru Suwa, Yoshihisa Nakagawa, Kazushige Kadota, Yoshiki Takatsu, Hideo Nishikawa, Yoshikazu Hiasa, Yasuhiko Hayashi, Shunichi Miyazaki, Takeshi Kimura
It is unknown whether there is a threshold of creatine kinase (CK) or CK-MB affecting the subsequent mortality for post-discharge myocardial infarction (PDMI) after percutaneous coronary intervention. Current study sought to evaluate the impact of PDMI. The study population included 30,051 patients with successful coronary stenting and discharged alive in the pooled patient-level database of 4 Japanese studies (j-Cypher registry, CREDO-Kyoto PCI/CABG registry cohort-2, RESET, and NEXT). During 4.4 ± 1...
March 5, 2018: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/29424280/the-peel-of-citrus-kawachiensis-kawachi-bankan-ameliorates-microglial-activation-tau-hyper-phosphorylation-and-suppression-of-neurogenesis-in-the-hippocampus-of-senescence-accelerated-mice
#11
Satoshi Okuyama, Yoshimi Kotani, Kana Yamamoto, Atsushi Sawamoto, Kuniaki Sugawara, Masahiko Sudo, Yuu Ohkubo, Arisa Tamanaha, Mitsunari Nakajima, Yoshiko Furukawa
We previously reported that the dried peel powder of Citrus kawachiensis, one of the citrus products of Ehime, Japan, exerted anti-inflammatory effects in the brain of a lipopolysaccharide-injected systemic inflammation animal model. Inflammation is one of the main mechanisms underlying aging in the brain; therefore, we herein evaluated the anti-inflammatory and other effects of the dried peel powder of C. kawachiensis in the senescence-accelerated mouse-prone 8 (SAMP8) model. The C. kawachiensis treatment inhibited microglial activation in the hippocampus, the hyper-phosphorylation of tau at 231 of threonine in hippocampal neurons, and ameliorated the suppression of neurogenesis in the dentate gyrus of the hippocampus...
May 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29391156/anti-il-23-receptor-monoclonal-antibody-prevents-cd4-t-cell-mediated-colitis-in-association-with-decreased-systemic-th1-and-th17-responses
#12
Emiko Imamura, Katsunari Taguchi, Haruna Sasaki-Iwaoka, Satoshi Kubo, Shigetada Furukawa, Tatsuaki Morokata
Experimental colitis studies, including T cell-mediated colitis, indicate that IL-23 rather than IL-12 orchestrates intestinal inflammation in inflammatory bowel disease (IBD). Previous studies have identified the roles of IL-12 and IL-23 using mice deficient for their specific subunits, p35 and p19, respectively. However, these studies do not completely reflect the difference in roles between IL-12 and IL-23, especially since the discovery of novel IL-12 family cytokines, which also include p35 or p19 subunits...
April 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29366795/documented-coronary-atherothrombosis-as-the-cause-of-death-in-post-discharge-patients-after-coronary-revascularization
#13
Hirotoshi Watanabe, Takeshi Morimoto, Hiroki Shiomi, Kyohei Yamaji, Satoshi Shizuta, Yutaka Furukawa, Yoshihisa Nakagawa, Kazushige Kadota, Kenji Ando, Ryuzo Sakata, Michiya Hanyu, Noboru Nishiwaki, Tatsuhiko Komiya, Takeshi Kimura
BACKGROUND: The contemporary medications for secondary prevention like statins and antithrombotic agents are targeting to delay the progression of atherothrombosis. However, there is limited data on the relation between death and progressive coronary atherothrombosis. This study sought to evaluate what proportion of death after coronary revascularization is related to documented progressive coronary atherothrombosis. METHODS: We reviewed the detailed causes of death among 15,231 patients receiving their first coronary revascularization enrolled in the CREDO-Kyoto PCI/CABG registry cohort-2, dividing into two groups; 13,839 patients with clinical success and without major complication (uncomplicated) and the other 1392 patients (complicated)...
December 21, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29356947/forensic-application-of-epidermal-aqp3-expression-to-determination-of-wound-vitality-in-human-compressed-neck-skin
#14
Yuko Ishida, Yumi Kuninaka, Mizuho Nosaka, Emi Shimada, Satoshi Hata, Hiroki Yamamoto, Yumiko Hashizume, Akihiko Kimura, Fukumi Furukawa, Toshikazu Kondo
In forensic practices, it is often difficult to determine wound vitality in compression marks of the neck with naked eyes. AQP1 and AQP3 are the major water channels associated with skin. Thus, we immunohistochemically examined the expression of AQP1 and AQP3 in neck skin samples to discuss their forensic applicability to determination of the wound vitality. Skin samples were obtained from 56 neck compression cases (hanging, 35 cases; strangulation, 21 cases). The intact skin from the same individual was taken as a control...
January 22, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29331986/sex-differences-in-impact-of-coronary-artery-calcification-to-predict-coronary-artery-disease
#15
Yoko M Nakao, Yoshihiro Miyamoto, Masahiro Higashi, Teruo Noguchi, Mitsuru Ohishi, Isao Kubota, Hiroyuki Tsutsui, Tomohiro Kawasaki, Yutaka Furukawa, Michihiro Yoshimura, Hideaki Morita, Kunihiro Nishimura, Akiko Kada, Yoichi Goto, Tomonori Okamura, Chuwa Tei, Hitonobu Tomoike, Hiroaki Naito, Satoshi Yasuda
OBJECTIVE: To assess sex-specific differences regarding use of conventional risks and coronary artery calcification (CAC) to detect coronary artery disease (CAD) using coronary CT angiography (CCTA). METHODS: The Nationwide Gender-specific Atherosclerosis Determinants Estimation and Ischemic Cardiovascular Disease Prospective Cohort study is a prospective, multicentre, nationwide cohort study. Candidates with suspected CAD aged 50-74 years enrolled from 2008 to 2012...
January 13, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29320574/acceleration-of-small-bowel-motility-after-oral-administration-of-dai-kenchu-to-tj-100-assessed-by-cine-magnetic-resonance-imaging
#16
Akitoshi Inoue, Akira Furukawa, Hiroshi Yamamoto, Shinichi Ohta, Nguyen Dai Hung Linh, Tulyeubai Syerikjan, Sachiko Kaida, Tsuyoshi Yamaguchi, Satoshi Murata, Toru Obata, Masaji Tani, Kiyoshi Murata
Dai-kenchu-to (TJ-100) is an herbal medicine used to shorten the duration of intestinal transit by accelerating intestinal movement. However, intestinal movement in itself has not been evaluated in healthy volunteers using radiography, fluoroscopy, and radioisotopes because of exposure to ionizing radiation. The purpose of this study was to evaluate the effect of TJ-100 on intestinal motility using cinematic magnetic resonance imaging (cine MRI) with a steady-state free precession sequence. Ten healthy male volunteers received 5 g of either TJ-100 or lactose without disclosure of the identity of the substance...
2018: PloS One
https://www.readbyqxmd.com/read/29246259/macrophages-in-trigeminal-ganglion-contribute-to-ectopic-mechanical-hypersensitivity-following-inferior-alveolar-nerve-injury-in-rats
#17
Dulguun Batbold, Masamichi Shinoda, Kuniya Honda, Akihiko Furukawa, Momoko Koizumi, Ryuta Akasaka, Satoshi Yamaguchi, Koichi Iwata
BACKGROUND: Accidental mandibular nerve injury may occur during tooth extraction or implant procedures, causing ectopic orofacial pain. The exact mechanisms underlying ectopic orofacial pain following mandibular nerve injury is still unknown. Here, we investigated the role of macrophages and tumor necrosis factor alpha (TNFα) in the trigeminal ganglion (TG) in ectopic orofacial pain following inferior alveolar nerve transection (IANX). METHODS: IANX was performed and the mechanical head-withdrawal threshold (MHWT) in the whisker pad skin ipsilateral to IANX was measured for 15 days...
December 16, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29234896/correction-to-multicenter-phase-ii-study-of-trastuzumab-plus-s-1-alone-in-elderly-patients-with-her2-positive-advanced-gastric-cancer-jaccro-gc%C3%A2-06
#18
Yutaka Kimura, Masashi Fujii, Toshiki Masuishi, Kazuhiro Nishikawa, Chikara Kunisaki, Satoshi Matsusaka, Yoshihiko Segawa, Masato Nakamura, Kinro Sasaki, Narutoshi Nagao, Yukimasa Hatachi, Yasuhiro Yuasa, Shinya Asami, Masahiro Takeuchi, Hiroshi Furukawa, Toshifusa Nakajima
The correct name of the twelfth author should be ''Yasuhiro Yuasa", and not ''Yasuhiko Yuasa'' as given in the original publication of the article.
December 12, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29164423/successful-radical-surgical-resection-of-initially-unresectable-intrahepatic-cholangiocarcinoma-by-downsizing-chemotherapy-with-gemcitabine-plus-cisplatin-a-case-report
#19
Ryosuke Takayanagi, Shigetsugu Takano, Kensuke Sugiura, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Atsushi Kato, Masaru Miyazaki, Masayuki Ohtsuka
BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is a subtype of biliary tract cancer (BTC). Recently, downsizing chemotherapy has been applied to initially unresectable BTCs, including ICC. CASE PRESENTATION: We report a case of liver resection in a 23-year-old woman who was diagnosed with initially unresectable ICC attached to the inferior vena cava, with portal vein (PV) cavernous transformation. Positron emission tomography (PET) showed fluorodeoxyglucose (FDG) uptake in the para-aortic lymph nodes...
November 21, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29146627/single-session-versus-staged-procedures-for-elective-multivessel-percutaneous-coronary-intervention
#20
Toshiaki Toyota, Takeshi Morimoto, Hiroki Shiomi, Kyohei Yamaji, Kenji Ando, Koh Ono, Satoshi Shizuta, Naritatsu Saito, Takao Kato, Shuichiro Kaji, Yutaka Furukawa, Yoshihisa Nakagawa, Kazushige Kadota, Minoru Horie, Takeshi Kimura
OBJECTIVES: To clarify the effect of single-session multivessel percutaneous coronary intervention (PCI) strategy relative to the staged multivessel strategy on clinical outcomes in patients with stable coronary artery disease (CAD) or non-ST-elevation acute coronary syndrome. METHODS: In the Coronary REvascularisation Demonstrating Outcome Study in Kyoto PCI/coronary artery bypass grafting registry cohort-2, there were 2018 patients who underwent elective multivessel PCI...
June 2018: Heart: Official Journal of the British Cardiac Society
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