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S Furukawa

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https://www.readbyqxmd.com/read/29749431/expression-of-annexin-ii-and-stromal-tenascin-c-promotes-epithelial-to-mesenchymal-transition-and-correlates-with-distant-metastasis-in-pancreatic-cancer
#1
Naoko Yoneura, Shigetsugu Takano, Hideyuki Yoshitomi, Yasuyuki Nakata, Reiri Shimazaki, Shingo Kagawa, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Masaru Miyazaki, Masayuki Ohtsuka
The interaction between cancer cells and stromal components contributes to cancer invasion and metastasis in pancreatic ductal adenocarcinoma (PDAC). The present study investigated the role of the correlation between annexin II (ANX2) and stromal tenascin C (TNC) with the progression of PDAC. The functions of the expression ANX2 and TNC were assessed in in vitro experiments using mouse and human PDAC cells, and the clinical effect was analyzed using immunohistochemistry with surgically resected PDAC tissues...
May 2, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29716344/spatial-measurement-in-rotating-magnetic-field-plasma-acceleration-method-by-using-two-dimensional-scanning-instrument-and-thrust-stand
#2
T Furukawa, K Takizawa, K Yano, D Kuwahara, S Shinohara
A two-dimensional scanning probe instrument has been developed to survey spatial plasma characteristics in our electrodeless plasma acceleration schemes. In particular, diagnostics of plasma parameters, e.g., plasma density, temperature, velocity, and excited magnetic field, are essential for elucidating physical phenomena since we have been concentrating on next generation plasma propulsion methods, e.g., Rotating Magnetic Field plasma acceleration method, by characterizing the plasma performance. Moreover, in order to estimate the thrust performance in our experimental scheme, we have also mounted a thrust stand, which has a target type, on this movable instrument, and scanned the axial profile of the thrust performance in the presence of the external magnetic field generated by using permanent magnets, so as to investigate the plasma captured in a stand area, considering the divergent field lines in the downstream region of a generation antenna...
April 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29714390/self-assembled-materials-and-supramolecular-chemistry-within-microfluidic-environments-from-common-thermodynamic-states-to-non-equilibrium-structures
#3
S Sevim, A Sorrenti, C Franco, S Furukawa, S Pané, A J deMello, J Puigmartí-Luis
Self-assembly is a crucial component in the bottom-up fabrication of hierarchical supramolecular structures and advanced functional materials. Control has traditionally relied on the use of encoded building blocks bearing suitable moieties for recognition and interaction, with targeting of the thermodynamic equilibrium state. On the other hand, nature leverages the control of reaction-diffusion processes to create hierarchically organized materials with surprisingly complex biological functions. Indeed, under non-equilibrium conditions (kinetic control), the spatio-temporal command of chemical gradients and reactant mixing during self-assembly (the creation of non-uniform chemical environments for example) can strongly affect the outcome of the self-assembly process...
May 1, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29614522/contribution-of-factor-viii-a2-domain-residues-400-409-to-a-factor-x-interactive-site-in-the-factor-xase-complex
#4
Masahiro Takeyama, Keiji Nogami, Kana Sasai, Shoko Furukawa, Midori Shima
The link between factor (F)VIII and FX is essential for optimum activity of the tenase complex. The interactive site(s) in FVIII for FX remains to be completely clarified, however. We investigated the FVIII A2 domain-FX association that was speculated from inhibitory mechanism(s) by an anti-A2 autoantibody. SDS-PAGE demonstrated that the purified inhibitor IgG recognizing residues 373-562 blocked FXa cleavage at Arg372 in FVIII, and surface-plasmon resonance (SPR)-based assays showed that intact A2 subunit directly bound to FX ( K d ; 63 nM)...
April 3, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29611870/initial-severity-of-major-depression-and-efficacy-of-new-generation-antidepressants-individual-participant-data-meta-analysis
#5
T A Furukawa, K Maruo, H Noma, S Tanaka, H Imai, K Shinohara, K Ikeda, S Yamawaki, S Z Levine, Y Goldberg, S Leucht, A Cipriani
OBJECTIVE: The role of baseline severity as effect modifier in various psychiatric disorders is a topic of controversy and of clinical import. This study aims to examine whether baseline severity modifies the efficacy of various antidepressants for major depression through individual participant data (IPD) meta-analysis. METHOD: We identified all placebo-controlled, double-blind randomised trials of new generation antidepressants in the acute phase treatment of major depression conducted in Japan and requested their IPD through the public-private partnerships (PPPs) between the relevant academic societies and the pharmaceutical companies...
April 3, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29552380/coherent-anti-stokes-raman-scattering-rigid-endoscope-toward-robot-assisted-surgery
#6
K Hirose, T Aoki, T Furukawa, S Fukushima, H Niioka, S Deguchi, M Hashimoto
Label-free visualization of nerves and nervous plexuses will improve the preservation of neurological functions in nerve-sparing robot-assisted surgery. We have developed a coherent anti-Stokes Raman scattering (CARS) rigid endoscope to distinguish nerves from other tissues during surgery. The developed endoscope, which has a tube with a diameter of 12 mm and a length of 270 mm, achieved 0.91% image distortion and 8.6% non-uniformity of CARS intensity in the whole field of view (650 μm diameter). We demonstrated CARS imaging of a rat sciatic nerve and visualization of the fine structure of nerve fibers...
February 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29528217/oligothiophene-indandione-linked-narrow-bandgap-molecules-impact-of-%C3%AF-conjugated-chain-length-on-photovoltaic-performance
#7
Hideaki Komiyama, Takahiro To, Seiichi Furukawa, Yu Hidaka, Woong Shin, Takahiro Ichikawa, Ryota Arai, Takuma Yasuda
Solution-processed organic solar cells (OSCs) based on narrow-bandgap small molecules hold great promise as next-generation energy-converting devices. In this paper, we focus on a family of A-π-D-π-A-type small molecules, namely, BDT-nT-ID (n = 1-4) oligomers, consisting of benzo[1,2-b:4,5-b']dithiophene (BDT) as the central electron-donating (D) core, 1,3-indandione (ID) as the terminal electron-accepting (A) units, and two regioregular oligo(3-hexylthiophene)s (nT) with different numbers of thiophene rings as the π-bridging units, and elucidate their structure-property-function relationships...
March 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29494308/rapid-bactericidal-action-of-propolis-against-porphyromonas-gingivalis
#8
Y Yoshimasu, T Ikeda, N Sakai, A Yagi, S Hirayama, Y Morinaga, S Furukawa, R Nakao
Propolis, a resinous substance produced by bees, is used as a folk medicine for treatment of periodontal diseases. However, its mode of the action and the compounds responsible for its activities remain obscure. In the present study, we comprehensively investigated the antibacterial activities of ethanol-extracted propolis (EEP) and EEP-derived compounds toward Porphyromonas gingivalis, a keystone pathogen for periodontal diseases. Broth microdilution and agar dilution assays were used to determine the minimum inhibitory concentrations of EEP against a range of oral bacterial species, of which P...
February 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29482613/identification-of-a-novel-mechanism-of-action-of-bovine-igg-antibodies-specific-for-staphylococcus-aureus
#9
Mutsumi Furukawa, Hiroshi Yoneyama, Eiji Hata, Hidetomo Iwano, Hidetoshi Higuchi, Tasuke Ando, Mika Sato, Tomohito Hayashi, Yoshio Kiku, Yuya Nagasawa, Kanae Niimi, Katsuki Usami, Kumiko Ito, Kouichi Watanabe, Tomonori Nochi, Hisashi Aso
Staphylococcus aureus is a major pathogen that causes subclinical mastitis associated with huge economic losses to the dairy industry. A few vaccines for bovine mastitis are available, and they are expected to induce the production of S. aureus-specific antibodies that prevent bacterial adherence to host cells or promote opsonization by phagocytes. However, the efficacy of such vaccines are still under debate; therefore, further research focusing on improving the current vaccines by seeking additional mechanisms of action is required to reduce economic losses due to mastitis in the dairy industry...
February 26, 2018: Veterinary Research
https://www.readbyqxmd.com/read/29440276/accurate-depth-of-radiofrequency-induced-lesions-in-renal-sympathetic-denervation-based-on-a-fine-histological-sectioning-approach-in-a-porcine-model
#10
Atsushi Sakaoka, Hisako Terao, Shintaro Nakamura, Hitomi Hagiwara, Toshihito Furukawa, Kiyoshi Matsumura, Kenichi Sakakura
BACKGROUND: Ablation lesion depth caused by radiofrequency-based renal denervation (RDN) was limited to <4 mm in previous animal studies, suggesting that radiofrequency-RDN cannot ablate a substantial percentage of renal sympathetic nerves. We aimed to define the true lesion depth achieved with radiofrequency-RDN using a fine sectioning method and to investigate biophysical parameters that could predict lesion depth. METHODS AND RESULTS: Radiofrequency was delivered to 87 sites in 14 renal arteries from 9 farm pigs at various ablation settings: 2, 4, 6, and 9 W for 60 seconds and 6 W for 120 seconds...
February 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29436609/enhancement-of-malignant-properties-of-human-glioma-cells-by-ganglioside-gd3-gd2
#11
Taiji Iwasawa, Pu Zhang, Yuki Ohkawa, Hiroyuki Momota, Toshihiko Wakabayashi, Yuhsuke Ohmi, Robiul H Bhuiyan, Keiko Furukawa, Koichi Furukawa
Sialic acid-containing glycosphingolipids, gangliosides, are considered as cancer associated antigens in neuro-ectoderm-derived tumors such as melanomas and neuroblastomas. In particular, gangliosides GD3 and GD2 are expressed in human gliomas. It has been reported that their expression levels increase along with increased malignant properties. However, the implication of GD3/GD2 in human glioma cells has never been clarified, at least to the best of our knowledge. In this study, we introduced the cDNA of GD3 synthase (GD3S)(ST8SIA1) into a glioma cell line, U-251MG, that expresses neither GD3 nor GD2, thereby establishing transfectant cells U-251MG-GD3S(+) expressing high levels of GD3 and GD2 on the cell surface...
April 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29394632/-combination-chemotherapy-including-intraperitoneal-ip-administration-of-paclitaxel-ptx-followed-by-ptx-cddp-and-s-1triplet-chemotherapy-for-cy1p0-gastric-cancer
#12
Masayuki Shinkai, Motohiro Imano, Yoko Hiraki, Hiroaki Kato, Mitsuru Iwama, Osamu Shiraishi, Atsushi Yasuda, Yutaka Kimura, Haruhiko Imamoto, Hiroshi Furukawa, Takushi Yasuda
BACKGROUND AND OBJECTIVES: We evaluate the feasibility and efficacy of combination chemotherapy including single intraperitoneal( IP)administration of paclitaxel(PTX), followed by triplet chemotherapy(PTX, cisplatin[CDDP]and S-1: PCS)for CY1P0 gastric cancer. METHODS: First of all, we performed staging laparoscopy and confirmed CY1P0, and secondary, administrated PTX intraperitoneally. Thirdly, patients received PCS chemotherapy for 2 courses. After antitumor effect had been confirmed, we performed second look laparoscopy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394540/-a-case-of-recurrent-gastric-cancer-with-grade-3-proteinuria-caused-by-ramucirumab-plus-paclitaxel-therapy
#13
Yutaka Kimura, Yoichi Makari, Jota Mikami, Yoko Hiraki, Hiroaki Kato, Mitsuru Iwama, Osamu Shiraishi, Atsushi Yasuda, Masayuki Shinkai, Motohiro Imano, Haruhiko Imamoto, Junya Fujita, Hiroshi Furukawa, Takushi Yasuda
Proteinuria is one of the characteristic adverse events by ramucirumab(RAM)plus paclitaxel(PTX)combination therapy for advanced gastric cancer. We reported a case of recurrent gastric cancer with grade(gr)3 proteinuria caused by RAM plus PTX therapy. 77-year-old woman was underwent distal gastrectomy in 76 years old for gastric cancer that was diagnosed mucinous adenocarcinoma, fStage III C(T4aN3H0P0CY0M0)and received adjuvant chemotherapy of S-1 for 1 year. She suffered from peritoneal recurrence with ascites after 1 year and 4 months of the operation and RAM(8mg/kg; day 1 and 15)plus PTX(80mg/m2; day 1, 8 and 15)therapy was administrated as second-line chemotherapy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394435/strain-rate-dependency-of-axonal-tolerance-for-uniaxial-stretching
#14
Hiromichi Nakadate, Evrim Kurtoglu, Hidenori Furukawa, Shoko Oikawa, Shigeru Aomura, Akira Kakuta, Yasuhiro Matsui
This study aims to clarify the relation between axonal deformation and the onset of axonal injury. Firstly, to examine the influence of strain rate on the threshold for axonal injury, cultured neurons were subjected to 12 types of stretching (strains were 0.10, 0.15, and 0.20 and strain rates were 10, 30, 50, and 70 s-1 ). The formation of axonal swellings and bulbs increased significantly at strain rates of 50 and 30 s-1 with strains of 0.15 and 0.20, respectively, even though those formations did not depend on strain rates in cultures exposed to a strain of 0...
November 2017: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/29368351/visualization-of-viscoelastic-behavior-in-skin-equivalent-using-optical-coherence-tomography-based-straingraphy
#15
Y Hara, Y Ogura, T Yamashita, D Furukawa, S Saeki
BACKGROUND/PURPOSE: The relationships between the skin components and these mechanical roles are still unclear. To clarify these relationships, we investigated spatial mapping of the mechanical behavior of cultured skin equivalents (SEs) using optical coherence tomography (OCT)-based straingraphy. METHODS: We built a strain relaxation test system combined with OCT and developed an algorithm that could visualize a time-dependent strain distribution, named dynamic-optical coherence straingraphy (D-OCSA)...
January 24, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29358420/comparative-efficacy-and-acceptability-of-antiepileptic-drugs-for-classical-trigeminal-neuralgia-a-bayesian-network-meta-analysis-protocol
#16
Zongshi Qin, Shang Xie, Zhi Mao, Yan Liu, Jiani Wu, Toshi A Furukawa, Joey S W Kwong, Jinhui Tian, Zhishun Liu
INTRODUCTION: Trigeminal neuralgia (TN) affects 4 to 28.9/100 000 people worldwide, and antiepileptic drugs such as carbamazepine and oxcarbazepine are the firstline treatment options. However, the efficacy and safety of other antiepileptic drugs remain unclear due to insufficient direct comparisons. OBJECTIVE: To compare the efficacy and acceptability of all currently available antiepileptic agents for the treatment of patients with classical TN. METHODS: We will search the PubMed, EMBASE, Cochrane Library and Web of Science databases for unpublished or undergoing research listed in registry platforms...
January 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29346344/development-of-immune-and-microbial-environments-is-independently-regulated-in-the-mammary-gland
#17
K Niimi, K Usami, Y Fujita, M Abe, M Furukawa, Y Suyama, Y Sakai, M Kamioka, N Shibata, E J Park, S Sato, H Kiyono, H Yoneyama, H Kitazawa, K Watanabe, T Nochi, H Aso
Breastfeeding is important for mammals, providing immunological and microbiological advantages to neonates, together with the nutritional supply from the mother. However, the mechanisms of this functional diversity in the mammary gland remain poorly characterized. Here, we show that, similar to the gastrointestinal tract, the mammary gland develops immune and microbial environments consisting of immunoglobulin A (IgA) and the microflora, respectively, both of which are important for protecting neonates and the mother from infectious diseases...
December 20, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/29290527/mutant-selection-window-of-four-quinolone-antibiotics-against-clinical-isolates-of-streptococcus-pneumoniae-haemophilus-influenzae-and-moraxella-catarrhalis
#18
Hajime Nakai, Takumi Sato, Takashi Uno, Emiko Furukawa, Masato Kawamura, Hiroshi Takahashi, Akira Watanabe, Shigeru Fujimura
Community-acquired pneumonia and otitis media are caused by several bacterial species, including Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. For the treatment of these diseases, various quinolones are frequently used. We determined the mutant prevention concentration (MPC) of four quinolones, levofloxacin, sitafloxacin, tosufloxacin, and garenoxacin, using 92 clinical isolates and evaluated each mutant selection window (MSW). Furthermore, the DNA sequence of the quinolone resistance-determining region (QRDR) for the resistant mutant selected based on the MSW was determined...
February 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29284057/computational-fluid-dynamics-cfd-using-porous-media-modeling-predicts-recurrence-after-coiling-of-cerebral-aneurysms
#19
Yasuyuki Umeda, Fujimaro Ishida, Masanori Tsuji, Kazuhiro Furukawa, Masato Shiba, Ryuta Yasuda, Naoki Toma, Hiroshi Sakaida, Hidenori Suzuki
OBJECTIVE: This study aimed to predict recurrence after coil embolization of unruptured cerebral aneurysms with computational fluid dynamics (CFD) using porous media modeling (porous media CFD). METHOD: A total of 37 unruptured cerebral aneurysms treated with coiling were analyzed using follow-up angiograms, simulated CFD prior to coiling (control CFD), and porous media CFD. Coiled aneurysms were classified into stable or recurrence groups according to follow-up angiogram findings...
2017: PloS One
https://www.readbyqxmd.com/read/29259145/fear-of-fear-and-broad-dimensions-of-psychopathology-over-the-course-of-cognitive-behavioural-therapy-for-panic-disorder-with-agoraphobia-in-japan
#20
S Ogawa, M Kondo, K Ino, T Ii, R Imai, T A Furukawa, T Akechi
OBJECTIVE: To examine the relationship of fear of fear and broad dimensions of psychopathology in panic disorder with agoraphobia over the course of cognitive behavioural therapy in Japan. METHODS: A total of 177 Japanese patients with panic disorder with agoraphobia were treated with group cognitive behavioural therapy between 2001 and 2015. We examined associations between the change scores in Agoraphobic Cognitions Questionnaire or Body Sensations Questionnaire and the changes in subscales of Symptom Checklist-90 Revised during cognitive behavioural therapy controlling the change in panic disorder severity using multiple regression analysis...
December 2017: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
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