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S Furukawa

Takeshi Kitai, Tomohiko Taniguchi, Takeshi Morimoto, Toshiaki Toyota, Chisato Izumi, Shuichiro Kaji, Kitae Kim, Naritatsu Saito, Kazuya Nagao, Tsukasa Inada, Eri Minamino-Muta, Takao Kato, Moriaki Inoko, Katsuhisa Ishii, Tadaaki Koyama, Ryuzo Sakata, Yutaka Furukawa, Takeshi Kimura
BACKGROUND: The ACC/AHA guidelines introduced a new classification of severe aortic stenosis (AS) mainly based on maximum jet velocity (Vmax) and mean pressure gradient (mPG), but not on aortic valve area (AVA). However, prognostic value of this new classification has not yet been fully evaluated. METHODS AND RESULTS: We studied 1512 patients with asymptomatic severe AS enrolled in the CURRENT AS registry in whom surgery was not initially planned. Patients were divided into 2 groups: Group 1 (N=122) comprised patients who met the recommendation for surgery; high-gradient (HG)-AS (Vmax≥4...
November 11, 2016: International Journal of Cardiology
S Furukawa, T Sakai, T Niiya, H Miyaoka, T Miyake, S Yamamoto, K Maruyama, T Ueda, H Senba, M Torisu, H Minami, M Onji, T Tanigawa, B Matsuura, Y Hiasa, Y Miyake
In several studies of patients with type 2 diabetes mellitus, a positive association between depressive symptoms and erectile dysfunction (ED) has been reported. No evidence exists, however, regarding the association between depressive symptoms and ED among Japanese patients with type 2 diabetes mellitus. Thus, we examined this issue among Japanese patients with type 2 diabetes mellitus. Study subjects were 469 male Japanese patients with type 2 diabetes mellitus, aged 19 years or over. ED, moderate to severe ED and severe ED were defined as present when a subject had a Sexual Health Inventory for Men score <22, <12 and <8, respectively...
November 17, 2016: International Journal of Impotence Research
H Furukawa, S Oka, N Tsuchiya, K Shimada, A Hashimoto, S Tohma, A Kawasaki
Associations between human leukocyte antigen (HLA) and susceptibility to systemic autoimmune diseases have been reported. The predisposing alleles are variable among ethnic groups and/or diseases. On the other hand, some HLA alleles are associated with resistance to systemic autoimmune diseases, including systemic sclerosis, systemic lupus erythematosus and rheumatoid arthritis. Interestingly, DRB1*13 alleles are the protective alleles shared by multiple autoimmune diseases. DRB1*13:01 allele is protective in European populations and DRB1*13:02 in Japanese...
November 10, 2016: Genes and Immunity
Zurab Siprashvili, Ngon T Nguyen, Emily S Gorell, Kylie Loutit, Phuong Khuu, Louise K Furukawa, H Peter Lorenz, Thomas H Leung, Douglas R Keene, Kerri E Rieger, Paul Khavari, Alfred T Lane, Jean Y Tang, M Peter Marinkovich
Importance: Recessive dystrophic epidermolysis bullosa (RDEB) is a devastating, often fatal, inherited blistering disorder caused by mutations in the COL7A1 gene encoding type VII collagen. Support and palliation are the only current therapies. Objective: To evaluate the safety and wound outcomes following genetically corrected autologous epidermal grafts in patients with RDEB. Design, Setting, and Participants: Single-center phase 1 clinical trial conducted in the United States of 4 patients with severe RDEB with a measured area of wounds suitable for grafting of at least 100 cm2...
November 1, 2016: JAMA: the Journal of the American Medical Association
A Ishiki, R Harada, N Okamura, N Tomita, C C Rowe, V L Villemagne, K Yanai, Y Kudo, H Arai, S Furumoto, M Tashiro, K Furukawa
BACKGROUND AND PURPOSE: Visualization of pathogenic protein aggregates is crucial to elucidate pathomechanisms and to make an accurate diagnosis in many neurodegenerative conditions. Aggregates of the microtubule-binding protein, tau, are one of the most important pathogenic molecules in neurodegenerative disorders. Progressive supranuclear palsy (PSP) is characterized by the deposition of tau proteins in some specific area such as the basal ganglia and brainstem. We tried to detect tau lesions in the brains of living patients with PSP with a novel positron emission tomography (PET) tracer, [(18) F]THK-5351, which we have recently developed...
October 31, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
S Furukawa, T Sakai, T Niiya, H Miyaoka, T Miyake, S Yamamoto, K Maruyama, T Ueda, H Senba, Y Todo, M Torisu, H Minami, M Onji, T Tanigawa, B Matsuura, Y Hiasa, Y Miyake
Only limited epidemiological evidence exists regarding the relationship between diabetic neuropathy and erectile dysfunction (ED) among Japanese patients with type 2 diabetes mellitus. To investigate the relationship between diabetic neuropathy and ED among Japanese patients with type 2 diabetes mellitus, a multicenter cross-sectional study was conducted in 287 male Japanese patients with type 2 diabetes mellitus, age (19-65 years). Diabetic neuropathy was diagnosed if the patients showed two or more of the following three characteristics: neuropathic symptoms, decreased or disappeared Achilles tendon reflex and/or abnormal vibration perception...
October 27, 2016: International Journal of Impotence Research
Sachiko Iizuka-Furukawa, Atsuko Isogai, Kazutaka Kusaka, Tsutomu Fujii, Yoshinori Wakai
The grassy characteristic aroma perceived in brewed sake made from low-glutelin rice (Oryza sativa L. Mizuhonoka) was examined by gas chromatography-olfactometry and gas chromatography-mass spectrometry. By comparing the odor properties and Kovats retention indices to those of standard compounds, 4-mercapto-4-methylpentan-2-one (4MMP) was found to contribute to the characteristic aroma. Sake brewing using Mizuhonoka, low-glutelin rice, and Gin-ohmi (a control) revealed that 4MMP concentrations in Mizuhonoka sake samples were higher than those in Gin-ohmi samples over the fermentation period...
October 20, 2016: Journal of Bioscience and Bioengineering
Akihiro Furukawa, Chad E Townsend, Joshua A Schwochert, Cameron R Pye, Maria A Bednarek, R Scott Lokey
Synthetic and natural cyclic peptides provide a testing ground for studying membrane permeability in non-traditional drug scaffolds. Cyclic peptomers, which incorporate peptide and N-alkylglycine (peptoid) residues, combine the stereochemical and geometric complexity of peptides with the functional group diversity accessible to peptoids. We synthesized cyclic peptomer libraries by split-pool techniques, separately permuting side chain and backbone geometry, and analyzed their membrane permeabilities using the parallel artificial membrane permeability assay (PAMPA)...
October 3, 2016: Journal of Medicinal Chemistry
Ariunzaya Tsolmonbaatar, Keisuke Hashida, Yukiko Sugimoto, Daisuke Watanabe, Shuhei Furukawa, Hiroshi Takagi
During bread-making processes, yeast cells are exposed to baking-associated stresses such as freeze-thaw, air-drying, and high-sucrose concentrations. Previously, we reported that self-cloning diploid baker's yeast strains that accumulate proline retained higher-level fermentation abilities in both frozen and sweet doughs than the wild-type strain. Although self-cloning yeasts do not have to be treated as genetically modified yeasts, the conventional methods for breeding baker's yeasts are more acceptable to consumers than the use of self-cloning yeasts...
December 5, 2016: International Journal of Food Microbiology
E Furukawa, B Alsop, P Sowerby, S Jensen, G Tripp
BACKGROUND: The behavioral sensitivity of children with ADHD to punishment has received limited theoretical and experimental attention. This study evaluated the effects of punishment on the response allocation of children with ADHD and typically developing children. METHOD: Two hundred and ten children, 145 diagnosed with ADHD, completed an operant task in which they chose between playing two simultaneously available games. Reward was arranged symmetrically across the games under concurrent variable interval schedules...
September 9, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
Keisuke Minami, Kihei Yoneyama, Masaki Izumo, Kengo Suzuki, Yasuyoshi Ogawa, Kousuke Chikaraishi, Yukihisa Ogawa, Yasuyuki Kobayashi, Toshiyuki Furukawa, Yasuhiro Tanabe, Yoshihiro J Akashi
BACKGROUND: Computed tomography is the best noninvasive imaging modality for evaluating valve leaflet calcification. OBJECTIVE: To evaluate the association of aortic valve leaflet calcification with instantaneous valve opening and closing using dynamic multidetector computed tomography (MDCT). METHODS: We retrospectively evaluated 58 consecutive patients who underwent dynamic MDCT imaging. Aortic valve calcification (AVC) was quantified using the Agatston method...
August 23, 2016: Journal of Cardiovascular Computed Tomography
Ichiro Furukawa, Tomoe Ishihara, Hiroshi Teranishi, Shioko Saito, Jun Yatsuyanagi, Eriko Wada, Yuko Kumagai, Shiho Takahashi, Takayuki Konno, Hiroko Kashio, Akihiko Kobayashi, Naoki Kato, Ken-Ichi Hayashi, Keisuke Fukushima, Kazuhiko Ishikawa, Kazumi Horikawa, Akira Oishi, Hidemasa Izumiya, Takahiro Ohnishi, Yoshiko Konishi, Toshiro Kuroki
This study was undertaken to determine the prevalence, antimicrobial susceptibility, and genetic relatedness of Salmonella enterica subsp. enterica and Campylobacter spp. in poultry meat, and to analyze the association of genetic types of these bacteria with their geographical distribution and antimicrobial resistance profiles. Fifty-four and 71 of 100 samples were found to be contaminated with Salmonella and Campylobacter, respectively. Nine Salmonella serotypes were found, including S. enterica subsp. enterica serovar Infantis (33%), Schwarzengrund (12%), Manhattan (9%), and others...
August 31, 2016: Japanese Journal of Infectious Diseases
S Klotz, K Komatsu, F Pietrucci, H Kagi, A-A Ludl, S Machida, T Hattori, A Sano-Furukawa, L E Bove
It has been known for decades that certain aqueous salt solutions of LiCl and LiBr readily form glasses when cooled to below ≈160 K. This fact has recently been exploited to produce a « salty » high-pressure ice form: When the glass is compressed at low temperatures to pressures higher than 4 GPa and subsequently warmed, it crystallizes into ice VII with the ionic species trapped inside the ice lattice. Here we report the extreme limit of salt incorporation into ice VII, using high pressure neutron diffraction and molecular dynamics simulations...
2016: Scientific Reports
Graham N Newton, Norihisa Hoshino, Takuto Matsumoto, Takuya Shiga, Motohiro Nakano, Hiroyuki Nojiri, Wolfgang Wernsdorfer, Yuji Furukawa, Hiroki Oshio
Here we report the synthesis, structure and detailed characterisation of three n-membered oxovanadium rings, Nan [(V=O)n Nan (H2 O)n (α, β, or γ-CD)2 ]⋅m H2 O (n=6, 7, or 8), prepared by the reactions of (V=O)SO4 ⋅x H2 O with α, β, or γ-cyclodextrins (CDs) and NaOH in water. Their alternating heterometallic vanadium/sodium cyclic core structures were sandwiched between two CD moieties such that O-Na-O groups separated the neighbouring vanadyl ions. Antiferromagnetic interactions between the S=1/2 vanadyl ions led to S=0 ground states for the even-membered rings, but to two quasi-degenerate S=1/2 states for the spin-frustrated heptanuclear cluster...
September 26, 2016: Chemistry: a European Journal
K Komatsu, F Noritake, S Machida, A Sano-Furukawa, T Hattori, R Yamane, H Kagi
No abstract text is available yet for this article.
2016: Scientific Reports
Koji Furukawa, Takeo Abumiya, Keiji Sakai, Miki Hirano, Toshiya Osanai, Hideo Shichinohe, Naoki Nakayama, Ken Kazumata, Kazutoshi Hida, Kiyohiro Houkin
BACKGROUND AND PURPOSE: High blood viscosity causes blood stagnation and subsequent pathological thrombotic events, resulting in the development of ischemic stroke. We hypothesize that the contribution of blood viscosity may differ among ischemic stroke subtypes based on specific pathological conditions. We tried to verify this hypothesis by measuring blood viscosity in acute ischemic stroke patients using a newly developed electromagnetic spinning sphere (EMS) viscometer. METHODS: Measurements in acute ischemic stroke patients were performed 4 times during admission and data were compared with those obtained from 100 healthy outpatient volunteers...
August 5, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Y Itani, A Arakawa, H Tsubamoto, K Ito, R Nishikawa, K Inoue, S Yamamoto, Y Miyagi, K Hori, N Furukawa
PURPOSE: To verify distress and impact thermometer (DIT) for screening emotional distress in gynecological cancer patients by Hospital Anxiety and Depression Scale total (HADS-T) as gold standard and to assess emotional changes by DIT and HADS-T. METHODS: A prospective study was conducted in newly diagnosed gynecological cancer patients during the peri-treatment period after the cancer diagnosis followed by 6-month. We defined a HADS-T score of ≥11 as being indicative of emotional distress...
August 3, 2016: Archives of Gynecology and Obstetrics
Valentin Taufour, Udhara S Kaluarachchi, Rustem Khasanov, Manh Cuong Nguyen, Zurab Guguchia, Pabitra Kumar Biswas, Pietro Bonfà, Roberto De Renzi, Xiao Lin, Stella K Kim, Eun Deok Mun, Hyunsoo Kim, Yuji Furukawa, Cai-Zhuang Wang, Kai-Ming Ho, Sergey L Bud'ko, Paul C Canfield
The temperature-pressure phase diagram of the ferromagnet LaCrGe_{3} is determined for the first time from a combination of magnetization, muon-spin-rotation, and electrical resistivity measurements. The ferromagnetic phase is suppressed near 2.1 GPa, but quantum criticality is avoided by the appearance of a magnetic phase, likely modulated, AFM_{Q}. Our density functional theory total energy calculations suggest a near degeneracy of antiferromagnetic states with small magnetic wave vectors Q allowing for the potential of an ordering wave vector evolving from Q=0 to finite Q, as expected from the most recent theories on ferromagnetic quantum criticality...
July 15, 2016: Physical Review Letters
O Janson, S Furukawa, T Momoi, P Sindzingre, J Richter, K Held
Motivated by recent experiments on volborthite single crystals showing a wide 1/3-magnetization plateau, we perform microscopic modeling by means of density functional theory (DFT) with the single-crystal structural data as a starting point. Using DFT+U, we find four leading magnetic exchanges: antiferromagnetic J and J_{2}, as well as ferromagnetic J^{'} and J_{1}. Simulations of the derived spin Hamiltonian show good agreement with the experimental low-field magnetic susceptibility and high-field magnetization data...
July 15, 2016: Physical Review Letters
Stefan Leucht, Anna Chaimani, Andrea S Cipriani, John M Davis, Toshi A Furukawa, Georgia Salanti
No abstract text is available yet for this article.
September 2016: European Archives of Psychiatry and Clinical Neuroscience
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