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https://www.readbyqxmd.com/read/28431893/proficiency-testing-with-uncertainty-evaluation-for-measuring-activities-per-unit-mass-of-134-cs-and-137-cs-in-brown-rice-in-japan
#1
R Furukawa, Y Unno, T Miura, A Yunoki, M Hachinohe, S Hamamatsu, H Itadzu, M Mizui
In Japan, we conducted proficiency testing of activity measurement by using high-purity germanium detectors for (134)Cs and (137)Cs in brown rice grains. Among 176 reported results, 86 % (for (134)Cs) and 93 % (for (137)Cs) of the results satisfied |En| ≦ 1. However, 58 reports for (134)Cs and 51 reports for (137)Cs had some failures in their evaluations of uncertainties. The proficiency testing was effective to improve the ability of uncertainty evaluation.
March 30, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28422173/critical-involvement-of-zeb2-in-collagen-fibrillogenesis-the-molecular-similarity-between-mowat-wilson-syndrome-and-ehlers-danlos-syndrome
#2
Mika Teraishi, Mikiro Takaishi, Kimiko Nakajima, Mitsunori Ikeda, Yujiro Higashi, Shinji Shimoda, Yoshinobu Asada, Atsushi Hijikata, Osamu Ohara, Yoko Hiraki, Seiji Mizuno, Toshiyuki Fukada, Takahisa Furukawa, Nobuaki Wakamatsu, Shigetoshi Sano
Mowat-Wilson syndrome (MOWS) is a congenital disease caused by de novo heterozygous loss of function mutations or deletions of the ZEB2 gene. MOWS patients show multiple anomalies including intellectual disability, a distinctive facial appearance, microcephaly, congenital heart defects and Hirschsprung disease. However, the skin manifestation(s) of patients with MOWS has not been documented in detail. Here, we recognized that MOWS patients exhibit many Ehlers-Danlos syndrome (EDS)-like symptoms, such as skin hyperextensibility, atrophic scars and joint hypermobility...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28414752/an-angiogenesis-platform-using-a-cubic-artificial-eggshell-with-patterned-blood-vessels-on-chicken-chorioallantoic-membrane
#3
Wenjing Huang, Makoto Itayama, Fumihito Arai, Katsuko S Furukawa, Takashi Ushida, Tomohiro Kawahara
The chorioallantoic membrane (CAM) containing tiny blood vessels is an alternative to large animals for studies involving angiogenesis and tissue engineering. However, there is no technique to design the direction of growing blood vessels on the CAM at the microscale level for tissue engineering experiments. Here, a methodology is provided to direct blood vessel formation on the surface of a three-dimensional egg yolk using a cubic artificial eggshell with six functionalized membranes. A structure on the lateral side of the eggshell containing a straight channel and an interlinked chamber was designed, and the direction and formation area of blood vessels with blood flow was artfully defined by channels with widths of 70-2000 μm, without sharply reducing embryo viability...
2017: PloS One
https://www.readbyqxmd.com/read/28408720/water-harvesting-from-air-with-metal-organic-frameworks-powered-by-natural-sunlight
#4
Hyunho Kim, Sungwoo Yang, Sameer R Rao, Shankar Narayanan, Eugene A Kapustin, Hiroyasu Furukawa, Ari S Umans, Omar M Yaghi, Evelyn N Wang
Atmospheric water is a resource equivalent to ~10% of all fresh water in lakes on Earth. However, an efficient process for capturing and delivering water from air, especially at low humidity levels (down to 20%), has not been developed. We report the design and demonstration of a device based on a porous metal-organic framework {MOF-801, [Zr6O4(OH)4(fumarate)6]} that captures water from the atmosphere at ambient conditions by using low-grade heat from natural sunlight at a flux of less than 1 sun (1 kilowatt per square meter)...
April 28, 2017: Science
https://www.readbyqxmd.com/read/28402012/a-stable-niii-porphyrin-meso-oxy-radical-with-a-quartet-ground-state
#5
Atsuhiro Osuka, Cosima Stähler, Daiki Shimizu, Kota Yoshida, Rainer Herges, Ko Furukawa
10,15-20-Tris(pentafluorophenyl)-substituted NiII-porphyrin meso-oxy radical bearing two coordinating pyridines was synthesized as a stable radical with a quartet ground state (S = 3/2). X-ray structural analysis has revealed that the NiII porphyrin moiety is fairly planar and the Ni-N bond lengths are considerably longer, indicating the high-spin state of the NiII center. The radical exhibited a quartet ground state, indicating the ferromagnetic interaction between the high-spin NiII center (S = 1) and the porphyrin meso-oxy radical (S = 1/2)...
April 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28323019/comparison-of-perceptual-properties-of-auditory-streaming-between-spectral-and-amplitude-modulation-domains
#6
Shimpei Yamagishi, Sho Otsuka, Shigeto Furukawa, Makio Kashino
The two-tone sequence (ABA_), which comprises two different sounds (A and B) and a silent gap, has been used to investigate how the auditory system organizes sequential sounds depending on various stimulus conditions or brain states. Auditory streaming can be evoked by differences not only in the tone frequency ("spectral cue": ΔFTONE, TONE condition) but also in the amplitude modulation rate ("AM cue": ΔFAM, AM condition). The aim of the present study was to explore the relationship between the perceptual properties of auditory streaming for the TONE and AM conditions...
March 17, 2017: Hearing Research
https://www.readbyqxmd.com/read/28259708/oral-aversion-to-dietary-sugar-ethanol-and-glycerol-correlates-with-alterations-in-specific-hepatic-metabolites-in-a-mouse-model-of-human-citrin-deficiency
#7
Takeyori Saheki, Kanako Inoue, Hiromi Ono, Yuki Fujimoto, Sumie Furuie, Ken-Ichi Yamamura, Eishi Kuroda, Miharu Ushikai, Akihiro Asakawa, Akio Inui, Kazuhiro Eto, Takashi Kadowaki, Mitsuaki Moriyama, David S Sinasac, Takashi Yamamoto, Tatsuhiko Furukawa, Keiko Kobayashi
Mice carrying simultaneous homozygous mutations in the genes encoding citrin, the mitochondrial aspartate-glutamate carrier 2 (AGC2) protein, and mitochondrial glycerol-3-phosphate dehydrogenase (mGPD), are a phenotypically representative model of human citrin (a.k.a., AGC2) deficiency. In this study, we investigated the voluntary oral intake and preference for sucrose, glycerol or ethanol solutions by wild-type, citrin (Ctrn)-knockout (KO), mGPD-KO, and Ctrn/mGPD double-KO mice; all substances that are known or suspected precipitating factors in the pathogenesis of human citrin deficiency...
February 14, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28224561/radical-resection-of-a-primary-unresectable-duodenal-cancer-after-chemotherapy-using-s-1-and-cisplatin-report-of-a-case
#8
Masaru Kanehira, Yasuro Futagawa, Kenei Furukawa, Hiroaki Shiba, Tadashi Uwagawa, Katsuhiko Yanaga
BACKGROUND: Therapeutic outcomes and prognosis of primary unresectable duodenal cancer remains unsatisfactory, because effective chemotherapy is not established. CASE PRESENTATION: A 71-year-old male diagnosed with unresectable duodenal carcinoma with distant lymph node metastases was judged inoperable (cT3N2M1 cStage in UICC(7th)). Duodenal obstruction developed due to tumor growth, and the patient underwent laparoscopic gastro-jejunostomy and then combined chemotherapy using S-1 and cisplatin...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28193873/two-types-of-amorphous-protein-particles-facilitate-crystal-nucleation
#9
Tomoya Yamazaki, Yuki Kimura, Peter G Vekilov, Erika Furukawa, Manabu Shirai, Hiroaki Matsumoto, Alexander E S Van Driessche, Katsuo Tsukamoto
Nucleation, the primary step in crystallization, dictates the number of crystals, the distribution of their sizes, the polymorph selection, and other crucial properties of the crystal population. We used time-resolved liquid-cell transmission electron microscopy (TEM) to perform an in situ examination of the nucleation of lysozyme crystals. Our TEM images revealed that mesoscopic clusters, which are similar to those previously assumed to consist of a dense liquid and serve as nucleation precursors, are actually amorphous solid particles (ASPs) and act only as heterogeneous nucleation sites...
February 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28190660/overview-of-biobank-japan-follow-up-data-in-32-diseases
#10
REVIEW
Makoto Hirata, Akiko Nagai, Yoichiro Kamatani, Toshiharu Ninomiya, Akiko Tamakoshi, Zentaro Yamagata, Michiaki Kubo, Kaori Muto, Yutaka Kiyohara, Taisei Mushiroda, Yoshinori Murakami, Koichiro Yuji, Yoichi Furukawa, Hitoshi Zembutsu, Toshihiro Tanaka, Yozo Ohnishi, Yusuke Nakamura, Koichi Matsuda
BACKGROUND: We established a patient-oriented biobank, BioBank Japan, with information on approximately 200,000 patients, suffering from any of 47 common diseases. This follow-up survey focused on 32 diseases, potentially associated with poor vital prognosis, and collected patient survival information, including cause of death. We performed a survival analysis for all subjects to get an overview of BioBank Japan follow-up data. METHODS: A total of 141,612 participants were included...
March 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28190657/cross-sectional-analysis-of-biobank-japan-clinical-data-a-large-cohort-of-200-000-patients-with-47-common-diseases
#11
Makoto Hirata, Yoichiro Kamatani, Akiko Nagai, Yutaka Kiyohara, Toshiharu Ninomiya, Akiko Tamakoshi, Zentaro Yamagata, Michiaki Kubo, Kaori Muto, Taisei Mushiroda, Yoshinori Murakami, Koichiro Yuji, Yoichi Furukawa, Hitoshi Zembutsu, Toshihiro Tanaka, Yozo Ohnishi, Yusuke Nakamura, Koichi Matsuda
BACKGROUND: To implement personalized medicine, we established a large-scale patient cohort, BioBank Japan, in 2003. BioBank Japan contains DNA, serum, and clinical information derived from approximately 200,000 patients with 47 diseases. Serum and clinical information were collected annually until 2012. METHODS: We analyzed clinical information of participants at enrollment, including age, sex, body mass index, hypertension, and smoking and drinking status, across 47 diseases, and compared the results with the Japanese database on Patient Survey and National Health and Nutrition Survey...
March 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28154173/autocrine-and-paracrine-interactions-between-multiple-myeloma-cells-and-bone-marrow-stromal-cells-by-growth-arrest-specific-gene-6-cross-talk-with-interleukin-6
#12
Miki Furukawa, Hiroshi Ohkawara, Kazuei Ogawa, Kazuhiko Ikeda, Koki Ueda, Akiko Shichishima-Nakamura, Emi Ito, Jun-Ichi Imai, Yuka Yanagisawa, Reiko Honma, Shinya Watanabe, Satoshi Waguri, Takayuki Ikezoe, Yasuchika Takeishi
The pathogenesis of multiple myeloma (MM) has not yet been fully elucidated. Our microarray analysis and immunohistochemistry revealed significant up-regulation of growth arrest-specific gene 6 (Gas6), a vitamin K-dependent protein with a structural homology with protein S, in bone marrow (BM) cells of MM patients. ELISA showed that the serum levels of soluble Gas6 were significantly increased in the MM patients when compared with healthy controls. Gas6 was overexpressed in the human CD138-positive MM cell line RPMI-8226...
March 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28133128/-a-case-of-surgical-resection-for-liver-metastasis-of-gastric-cancer-treated-with-neoadjuvant-chemotherapy
#13
Soichiro Mori, Masahiro Tanemura, Kentaro Kishi, Mitsuyoshi Tei, Toru Masuzawa, Yozo Suzuki, Masahisa Otsuka, Kenta Furukawa, Yoshihiro Sakano, Kazunori Mori, Hiroki Akamatsu
The patient was a 73-year-old man. Upper gastrointestinal endoscopy revealed a type 3 tumor in the antrum of the stomach. Preoperative CT imaging showed multiple liver metastases(S2, S3, S4, S6, S7). We administered 2 courses of chemotherapy( XP therapy)for the unresectable gastric cancer; the impact of the neoadjuvant therapy was PR. We performed distal gastrectomy and D2 dissection. After gastric resection, we administered an additional 3 courses of XP therapy. Unfortunately, new lesions of liver metastases were recurrent at S5 and S8...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133061/-curative-resection-for-chemorefractory-advanced-gastric-cancer-with-pancreatic-invasion-by-pancreatoduodenectomy-a-case-report
#14
Masahiro Koh, Kentaro Kishi, Ryo Tsukada, Masahiro Tanemura, Mitsuyoshi Tei, Toru Masuzawa, Yozo Suzuki, Kenta Furukawa, Mikako Ikehara, Hiroki Akamatsu
A 37-year-old woman was diagnosed with advanced gastric cancer. Pancreatic invasion of the tumor and positive cytology from peritoneal washing was found on staging laparoscopy. The patient received chemotherapy consisting of S-1 and CDDP, but the tumor size increased after 5 courses. The patient then received 2 courses of second line chemotherapy consisting of biweekly CPT-11; however, the tumor progressed and caused stenosis of the stomach. After gastrojejunostomy for the stenosis, negative cytology of intraperitoneal lavage was found...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28104735/initial-severity-of-depression-and-efficacy-of-cognitive-behavioural-therapy-individual-participant-data-meta-analysis-of-pill-placebo-controlled-trials
#15
REVIEW
Toshi A Furukawa, Erica S Weitz, Shiro Tanaka, Steven D Hollon, Stefan G Hofmann, Gerhard Andersson, Jos Twisk, Robert J DeRubeis, Sona Dimidjian, Ulrich Hegerl, Roland Mergl, Robin B Jarrett, Jeffrey R Vittengl, Norio Watanabe, Pim Cuijpers
BackgroundThe influence of baseline severity has been examined for antidepressant medications but has not been studied properly for cognitive-behavioural therapy (CBT) in comparison with pill placebo.AimsTo synthesise evidence regarding the influence of initial severity on efficacy of CBT from all randomised controlled trials (RCTs) in which CBT, in face-to-face individual or group format, was compared with pill-placebo control in adults with major depression.MethodA systematic review and an individual-participant data meta-analysis using mixed models that included trial effects as random effects...
March 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28069106/portal-vein-thrombosis-after-reconstruction-in-270-consecutive-patients-with-portal-vein-resections-in-hepatopancreatobiliary-hpb-surgery
#16
Masaru Miyazaki, Hiroaki Shimizu, Masayuki Ohtuka, Atsushi Kato, Hiroyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Daisuke Suzuki, Taku Higashihara
BACKGROUNDS: This study was aimed to evaluate the occurrence of portal vein thrombosis after portal vein reconstruction. METHODS: The portal veins were repaired with venorrhaphy, end-to-end, patch graft, and segmental graft in consecutive 270 patients undergoing hepato-pancreto-biliary (HPB) surgery. RESULTS: Portal vein thrombosis was encountered in 20 of 163 of end-to-end, 2 of 56 of venorrhaphy, and 2 of 5 of patch graft groups, as compared with 0 of 46 of segmental graft group (p < 0...
December 24, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27995327/quantitative-diagnosis-of-chronic-pancreatitis-using-eus-elastography
#17
Takamichi Kuwahara, Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Manabu Kawai, Hiroki Suhara, Tomoaki Takeyama, Kiyotaka Hashizume, Toshinari Koya, Hiroyuki Tanaka, Daisuke Sakai, Takeshi Yamamura, Kazuhiro Furukawa, Kohei Funasaka, Masanao Nakamura, Ryoji Miyahara, Osamu Watanabe, Masatoshi Ishigami, Senju Hashimoto, Hidemi Goto
BACKGROUND: It is difficult to diagnose chronic pancreatitis (CP) objectively because of a lack of standard diagnostic criteria. Endoscopic ultrasonography (EUS) has been used to assess the severity of CP, but the diagnosis of CP using EUS depends on an endosnonographer. The aim of this study was to establish an objective diagnostic method for CP using EUS elastography (EUS-EG). METHODS: A retrospective study was designed and 96 patients underwent EUS-EG for follow-up of known CP, or who were clinically suspected as having CP...
December 19, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27994106/resistance-to-first-line-antituberculosis-drugs-in-washington-state-by-region-of-birth-and-implications-for-latent-tuberculosis-treatment-among-foreign-born-individuals
#18
Nathan W Furukawa, Mahri Z Haider, Sheanne J Allen, Sherry L Carlson, Scott W Lindquist
The United States has a low burden of drug resistance among tuberculosis (TB) cases compared with other world regions. TB is increasingly concentrated among foreign-born individuals who have higher rates of drug resistance than U.S.-born individuals. While universal drug susceptibility testing is the standard for detecting active tuberculosis, there are limited guidelines for latent tuberculosis infection (LTBI) treatment based on risk factors for drug resistance. To quantify the variable risk of drug resistance among foreign-born individuals, all TB cases in Washington State between 1994 and 2014 with drug resistance data for isoniazid, rifampin, pyrazinamide, and ethambutol were divided into eight regions of birth...
December 19, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27993950/in-situ-straining-and-time-resolved-electron-tomography-data-acquisition-in-a-transmission-electron-microscope
#19
S Hata, S Miyazaki, T Gondo, K Kawamoto, N Horii, K Sato, H Furukawa, H Kudo, H Miyazaki, M Murayama
This paper reports the preliminary results of a new in-situ three-dimensional (3D) imaging system for observing plastic deformation behavior in a transmission electron microscope (TEM) as a directly relevant development of the recently reported straining-and-tomography holder [Sato K et al. (2015) Development of a novel straining holder for transmission electron microscopy compatible with single tilt-axis electron tomography. Microsc. 64: 369-375]. We designed an integrated system using the holder and newly developed straining and image-acquisition software and then developed an experimental procedure for in-situ straining and time-resolved electron tomography (ET) data acquisition...
April 1, 2017: Microscopy
https://www.readbyqxmd.com/read/27983908/calcium-concentration-in-culture-medium-as-a-nondestructive-and-rapid-marker-of-osteogenesis
#20
Yohei Tanikake, Manabu Akahane, Akira Furukawa, Yasuaki Tohma, Yusuke Inagaki, Tsutomu Kira, Yasuhito Tanaka
Artificial bones made of &#946;-tricalcium phosphate (&#946;-TCP) combined with bone marrowderived stromal cells (BMSCs) are used for effective reconstruction of bone defects caused by genetic defects, traumatic injury, or surgical resection of bone tumors. However, the selection of constructs with high osteogenic potential before implantation is challenging. The purpose of this study was to determine whether the calcium concentration in BMSC culture medium can be used as a nondestructive and simple osteogenic marker for selecting tissueengineered grafts constructed using &#946;-TCP and BMSCs...
November 29, 2016: Cell Transplantation
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