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https://www.readbyqxmd.com/read/29142173/effect-of-dibutyltin-on-placental-and-fetal-toxicity-in-rat
#1
Satoshi Furukawa, Naho Tsuji, Yoshiyuki Kobayashi, Yoshikazu Yamagishi, Seigo Hayashi, Masayoshi Abe, Yusuke Kuroda, Masayuki Kimura, Chisato Hayakawa, Akihiko Sugiyama
In order to elucidate the effect of chorioallantoic and yolk sac placenta on the embryonic/fetal toxicity in dibutyltin dichloride (DBTCl)-exposed rats, we examined the histopathological changes and the tissue distribution of dibutyltin in the placentas and embryos. DBTCl was orally administered to the groups at doses of 0 mg/kg during gestation days (GD)s 7-9 (control group) and 20 mg/kg during GDs 7-9 (GD7-9 treated group), and GDs 10-12 (GD10-12 treated group). The total fetal mortality was increased, and malformations characterized by craniofacial dysmorphism were detected in the GD7-9 treated group...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29137891/human-leukocyte-antigen-hla-and-gulf-war-illness-gwi-hla-drb1-13-02-spares-subcortical-atrophy-in-gulf-war-veterans
#2
Lisa M James, Peka Christova, Brian E Engdahl, Scott M Lewis, Adam F Carpenter, Apostolos P Georgopoulos
BACKGROUND: Gulf War Illness (GWI) is a multisystem disorder that has affected a substantial number of veterans who served in the 1990-91 Gulf War. The brain is prominently affected, as manifested by the presence of neurological, cognitive and mood symptoms. We reported previously on the protective role of six Human Leukocyte Antigen (HLA) alleles in GWI (Georgopoulos et al., 2016) and their association with regional brain function (James et al., 2016). More recently, we reported on the presence of subcortical brain atrophy in GWI (Christova et al...
November 9, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29089236/homogeneity-of-wheat-flour-in-5ml-containers-for-certified-reference-materials
#3
R Furukawa, Y Unno, T Miura, A Yunoki, M Hachinohe, S Hamamatsu
We aimed to develop certified reference materials that could be used for well-type HPGe detector. We chose wheat flour as a sample and evaluated the homogeneity of the sample in well-type container (5ml). Results showed that inhomogeneity was sufficiently small for validation checks of well-type HPGe detector (uhom = 0.44%).
October 6, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29051107/advances-in-the-grade-approach-to-rate-the-certainty-in-estimates-from-a-network-meta-analysis
#4
Romina Brignardello-Petersen, Ashley Bonner, Paul E Alexander, Reed A Siemieniuk, Toshi A Furukawa, Bram Rochwerg, Glen S Hazlewood, Waleed Alhazzani, Reem A Mustafa, M Hassan Murad, Milo A Puhan, Holger J Schünemann, Gordon H Guyatt
This article describes conceptual advances of the Grading of Recommendations Assessments, Development, and Evaluation (GRADE) working group guidance to evaluate certainty of evidence (confidence in evidence, quality of evidence) from network meta-analysis (NMA). Application of the original GRADE guidance, published in 2014, in a number of NMAs has resulted in advances that strengthen its conceptual basis and make the process more efficient. This guidance will be useful for systematic reviewer authors who aim to assess the certainty of all pairwise comparisons from an NMA and who are familiar with the basic concepts of NMA and the traditional GRADE approach for pairwise meta-analysis...
October 16, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29046924/liquid-chromatography-mass-spectrometry-with-triazole-bonded-stationary-phase-for-n-methyl-d-aspartate-receptor-related-amino-acids-development-and-application-in-microdialysis-studies
#5
Tatsuya Sakamoto, Riho Onuma, Shoko Furukawa, Akane Hayasaka, Mayu Onozato, Hiromi Nakazawa, Hideaki Iizuka, Hideaki Ichiba, Takeshi Fukushima
We aimed to monitor changes in the levels of amino acid neurotransmitters or neuromodulators simultaneously at the synaptic clefts of experimental animals. We developed a method for the simultaneous determination of the levels of amino acids, such as D-Ser, Gly, and L-Glu, which were involved in neurotransmission via the N-methyl-D-aspartate (NMDA) receptor, and other protein-constituted amino acids in a rat brain microdialysis (MD) sample. We used a liquid chromatography-mass spectrometry (LC-MS)/MS device equipped with a triazole-bonded column...
October 18, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28973913/period2-3-utr-and-microrna-24-regulate-circadian-rhythms-by-repressing-period2-protein-accumulation
#6
Seung-Hee Yoo, Shihoko Kojima, Kazuhiro Shimomura, Nobuya Koike, Ethan D Buhr, Tadashi Furukawa, Caroline H Ko, Gabrielle Gloston, Christopher Ayoub, Kazunari Nohara, Bryan A Reyes, Yoshiki Tsuchiya, Ook-Joon Yoo, Kazuhiro Yagita, Choogon Lee, Zheng Chen, Shin Yamazaki, Carla B Green, Joseph S Takahashi
We previously created two PER2::LUCIFERASE (PER2::LUC) circadian reporter knockin mice that differ only in the Per2 3'-UTR region: Per2::Luc, which retains the endogenous Per2 3'-UTR and Per2::LucSV, where the endogenous Per2 3'-UTR was replaced by an SV40 late poly(A) signal. To delineate the in vivo functions of Per2 3'-UTR, we analyzed circadian rhythms of Per2::LucSV mice. Interestingly, Per2::LucSV mice displayed more than threefold stronger amplitude in bioluminescence rhythms than Per2::Luc mice, and also exhibited lengthened free-running periods (∼24...
October 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28953959/hypergravity-down-regulates-c-fos-gene-expression-via-rock-rho-gtp-and-the-pi3k-signaling-pathway-in-murine-atdc5-chondroprogenitor-cells
#7
Jeonghyun Kim, Kevin Montagne, Hidetoshi Nemoto, Takashi Ushida, Katsuko S Furukawa
Chondrocytes are known to be physiologically loaded with diverse physical factors such as compressive stress, shear stress and hydrostatic pressure. Although the effects of those mechanical stimuli onto various cell models have been widely studied, those of hypergravity have not yet been revealed clearly. Hereby, we hypothesized that the hypergravity affects relative positions of intracellular elements including nucleus and cytoskeletons due to their density differences, triggering mechanotransduction in the cell...
2017: PloS One
https://www.readbyqxmd.com/read/28936560/multicenter-phase-ii-study-of-trastuzumab-plus-s-1-alone-in-elderly-patients-with-her2-positive-advanced-gastric-cancer-jaccro-gc-06
#8
Yutaka Kimura, Masashi Fujii, Toshiki Masuishi, Kazuhiro Nishikawa, Chikara Kunisaki, Satoshi Matsusaka, Yoshihiko Segawa, Masato Nakamura, Kinro Sasaki, Narutoshi Nagao, Yukimasa Hatachi, Yasuhiko Yuasa, Shinya Asami, Masahiro Takeuchi, Hiroshi Furukawa, Toshifusa Nakajima
BACKGROUND: S-1 plus cisplatin is a standard regimen for advanced gastric cancer (AGC) in Asia. The ToGA trial established a fluoropyrimidine plus cisplatin and trastuzumab as a standard treatment for human epidermal growth factor receptor 2 (HER2)-positive AGC. In the HERBIS-1 trial, trastuzumab combined with S-1 plus cisplatin showed promising antitumor activity in patients with HER2-positive AGC. However, cisplatin has several important drawbacks, including vomiting and renal toxicity...
September 21, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28900001/samd7-is-a-cell-type-specific-prc1-component-essential-for-establishing-retinal-rod-photoreceptor-identity
#9
Yoshihiro Omori, Shun Kubo, Tetsuo Kon, Mayu Furuhashi, Hirotaka Narita, Taro Kominami, Akiko Ueno, Ryotaro Tsutsumi, Taro Chaya, Haruka Yamamoto, Isao Suetake, Shinji Ueno, Haruhiko Koseki, Atsushi Nakagawa, Takahisa Furukawa
Precise transcriptional regulation controlled by a transcription factor network is known to be crucial for establishing correct neuronal cell identities and functions in the CNS. In the retina, the expression of various cone and rod photoreceptor cell genes is regulated by multiple transcription factors; however, the role of epigenetic regulation in photoreceptor cell gene expression has been poorly understood. Here, we found that Samd7, a rod-enriched sterile alpha domain (SAM) domain protein, is essential for silencing nonrod gene expression through H3K27me3 regulation in rod photoreceptor cells...
September 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28839287/self-propelled-ion-gel-at-air-water-interface
#10
Kazuaki Furukawa, Tetsuhiko Teshima, Yuko Ueno
We report on a self-propelled gel using ionic liquid as a new type of self-propellant that generates a powerful and durable motion at an air-water interface. The gel is composed of 1-ethyl-3-methylimidazolium-bis(trifluoromethylsulfonyl)imide (EMIM-TFSI) and poly(vinylidene fluoride-co-hexafluoropropylene) (P(VDF-co-HFP)). A long rectangular ion gel piece placed on the interface shows rapid rotation motion with maximum frequency close to 10 Hz, corresponding to the velocity over 300 mms(-1) at an outmost end of the piece...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28815903/rhenium-loaded-tio2-a-highly-versatile-and-chemoselective-catalyst-for-the-hydrogenation-of-carboxylic-acid-derivatives-and-the-n-methylation-of-amines-using-h2-and-co2
#11
Takashi Toyao, S M A H Siddiki, Yoshitsugu Morita, Takashi Kamachi, Abeda S Touchy, Wataru Onodera, Kenichi Kon, Shinya Furukawa, Hiroko Ariga, Kiyotaka Asakura, Kazunari Yoshizawa, Ken-Ichi Shimizu
Herein, we report a heterogeneous TiO2 -supported Re catalyst (Re/TiO2 ) that promotes various selective hydrogenation reactions, which includes the hydrogenation of esters to alcohols, the hydrogenation of amides to amines, and the N-methylation of amines, by using H2 and CO2 . Initially, Re/TiO2 was evaluated in the context of the selective hydrogenation of 3-phenylpropionic acid methyl ester to afford 3-phenylpropanol (pH2 =5 MPa, T=180 °C), which revealed a superior performance over other catalysts that we tested in this study...
August 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28813497/high-hydrostatic-pressure-induces-pro-osteoarthritic-changes-in-cartilage-precursor-cells-a-transcriptome-analysis
#12
Kevin Montagne, Yasuko Onuma, Yuzuru Ito, Yasuhiko Aiki, Katsuko S Furukawa, Takashi Ushida
Due to the high water content of cartilage, hydrostatic pressure is likely one of the main physical stimuli sensed by chondrocytes. Whereas, in the physiological range (0 to around 10 MPa), hydrostatic pressure exerts mostly pro-chondrogenic effects in chondrocyte models, excessive pressures have been reported to induce detrimental effects on cartilage, such as increased apoptosis and inflammation, and decreased cartilage marker expression. Though some genes modulated by high pressure have been identified, the effects of high pressure on the global gene expression pattern have still not been investigated...
2017: PloS One
https://www.readbyqxmd.com/read/28810691/improvement-of-implantation-potential-in-mouse-blastocysts-derived-from-ivf-by-combined-treatment-with-prolactin-epidermal-growth-factor-and-4-hydroxyestradiol
#13
Miki Takeuchi, Misato Seki, Etsuko Furukawa, Akihito Takahashi, Kyosuke Saito, Mitsuru Kobayashi, Kenji Ezoe, Emiko Fukui, Midori Yoshizawa, Hiromichi Matsumoto
STUDY QUESTION: Can supplementation of medium with prolactin (PRL), epidermal growth factor (EGF) and 4-hydroxyestradiol (4-OH-E2) prior to embryo transfer improve implantation potential in mouse blastocysts derived from IVF? SUMMARY ANSWER: Combined treatment with PRL, EGF and 4-OH-E2 improves mouse blastocyst implantation rates, while alone, each factor is ineffective. WHAT IS KNOWN ALREADY: Blastocyst dormancy during delayed implantation caused by ovariectomy is maintained by continued progesterone treatment in mice, and estrogen injection rapidly activates blastocysts to implantation-induced status in vivo...
August 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28800452/identification-of-3-4-dihydro-2h-thiochromene-1-1-dioxide-derivatives-with-a-phenoxyethylamine-group-as-highly-potent-and-selective-%C3%AE-1d-adrenoceptor-antagonists
#14
Nobuki Sakauchi, Hideki Furukawa, Junya Shirai, Ayumu Sato, Haruhiko Kuno, Reiko Saikawa, Masato Yoshida
A series of phenoxyethylamine derivatives was designed and synthesized to discover potent and selective human α1D adrenoceptor (α1D adrenergic receptor; α1D-AR) antagonists. Compound 7 was taken from our internal compound collection as an attractive starting point and exhibited moderate binding affinity for α1D-AR and high selectivity against α1A- and α1B-ARs. We focused on modifying the 2-methylsulfonylbenzyl group of 7 to discover novel compounds structurally distinct from other reported α1-AR antagonists containing the phenoxyethylamine motif...
October 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28781812/non-neural-granular-cell-tumor-of-the-uterine-corpus-mimicking-uterine-leiomyoma-a-case-report
#15
Yoko Deguchi, Naoyuki Iwahashi, Yuko Horiuchi, Miwa Ikejima, Tomoyuki Tanaka, Kazuhiko Ino, Kenichi Furukawa
Non-neural granular cell tumors (GCTs) are clinically rare, whereas cases arising in the uterine corpus are exceedingly rare. Only three uterine cervical cases of GCTs have been reported to date and, to the best of our knowledge, there are no reports of GCT of the uterine corpus in the literature. We herein describe the first case of non-neural GCT arising from the uterine corpus reported to date. A 55-year-old premenopausal woman was referred to the Department of Obstetrics and Gynecology of Hashimoto Municipal Hospital (Wakayama, Japan) with a suspected uterine tumor...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28776573/pancreatic-intraductal-tubulopapillary-neoplasm-is-genetically-distinct-from-intraductal-papillary-mucinous-neoplasm-and-ductal-adenocarcinoma
#16
Olca Basturk, Michael F Berger, Hiroshi Yamaguchi, Volkan Adsay, Gokce Askan, Umesh K Bhanot, Ahmet Zehir, Fatima Carneiro, Seung-Mo Hong, Giuseppe Zamboni, Esra Dikoglu, Vaidehi Jobanputra, Kazimierz O Wrzeszczynski, Serdar Balci, Peter Allen, Naoki Ikari, Shoko Takeuchi, Hiroyuki Akagawa, Atsushi Kanno, Tooru Shimosegawa, Takanori Morikawa, Fuyuhiko Motoi, Michiaki Unno, Ryota Higuchi, Masakazu Yamamoto, Kyoko Shimizu, Toru Furukawa, David S Klimstra
Intraductal tubulopapillary neoplasm is a relatively recently described member of the pancreatic intraductal neoplasm family. The more common member of this family, intraductal papillary mucinous neoplasm, often carries genetic alterations typical of pancreatic infiltrating ductal adenocarcinoma (KRAS, TP53, and CDKN2A) but additionally has mutations in GNAS and RNF43 genes. However, the genetic characteristics of intraductal tubulopapillary neoplasm have not been well characterized. Twenty-two intraductal tubulopapillary neoplasms were analyzed by either targeted next-generation sequencing, which enabled the identification of sequence mutations, copy number alterations, and selected structural rearrangements involving all targeted (≥300) genes, or whole-exome sequencing...
August 4, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28714588/cellular-force-assay-detects-altered-contractility-caused-by-a-nephritis-associated-mutation-in-nonmuscle-myosin-iia
#17
Shota P Fukuda, Tsubasa S Matsui, Takafumi Ichikawa, Taichi Furukawa, Noriyuki Kioka, Shuichiro Fukushima, Shinji Deguchi
Recent progress in understanding the essential roles of mechanical forces in regulating various cellular processes expands the field of biology to one where interdisciplinary approaches with engineering techniques become indispensable. Contractile forces or contractility-inherently present in proliferative cells due to the activity of ubiquitous nonmuscle myosin II (NMII)-are one of such mechano-regulators, but because NMII works downstream of diverse signaling pathways, it is often difficult to predict how the inherent cellular forces change upon perturbations to particular molecules...
July 17, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/28704973/the-mode-of-action-of-cyclo-l-ala-l-pro-in-inhibiting-aflatoxin-production-of-aspergillus-flavus
#18
Kurin Iimura, Tomohiro Furukawa, Toshiyoshi Yamamoto, Lumi Negishi, Michio Suzuki, Shohei Sakuda
Cyclo(l-Ala-l-Pro) inhibits aflatoxin production in aflatoxigenic fungi without affecting fungal growth. The mode of action of cyclo(l-Ala-l-Pro) in inhibiting aflatoxin production of Aspergillus flavus was investigated. A glutathione S-transferase (GST) of the fungus, designated AfGST, was identified as a binding protein of cyclo(l-Ala-l-Pro) in an experiment performed using cyclo(l-Ala-l-Pro)-immobilized Sepharose beads. Cyclo(l-Ala-l-Pro) specifically bound to recombinant AfGST and inhibited its GST activity...
July 12, 2017: Toxins
https://www.readbyqxmd.com/read/28688691/impact-of-combined-modality-treatment-with-radiotherapy-and-s-1-on-t2n0-laryngeal-cancer-possible-improvement-in-survival-through-the-prevention-of-second-primary-cancer-and-distant-metastasis
#19
Yosuke Kitani, Akira Kubota, Madoka Furukawa, Yukiko Hori, Yuko Nakayama, Tetsuo Nonaka, Nobutaka Mizoguchi, Yuka Kitani, Hiromitsu Hatakeyama, Nobuhiko Oridate
BACKGROUND: In patients with head and neck cancer, the management of second primary cancer (SPC) is particularly important for improving survival because of its high incidence and associated mortality. We evaluated the impact of combination chemotherapy on survival and SPC. METHOD: We retrospectively analyzed data from 49 patients treated with definitive radiation therapy (RT) for T2N0M0 laryngeal squamous cell carcinoma between 2003 and 2011. Among them, 22 patients received combined modality treatment with radiotherapy and S-1 (RT+CT group)...
August 2017: Oral Oncology
https://www.readbyqxmd.com/read/28649427/global-rise-of-potential-health-hazards-caused-by-blue-light-induced-circadian-disruption-in-modern-aging-societies
#20
REVIEW
Megumi Hatori, Claude Gronfier, Russell N Van Gelder, Paul S Bernstein, Josep Carreras, Satchidananda Panda, Frederick Marks, David Sliney, Charles E Hunt, Tsuyoshi Hirota, Toshiharu Furukawa, Kazuo Tsubota
Mammals receive light information through the eyes, which perform two major functions: image forming vision to see objects and non-image forming adaptation of physiology and behavior to light. Cone and rod photoreceptors form images and send the information via retinal ganglion cells to the brain for image reconstruction. In contrast, nonimage-forming photoresponses vary widely from adjustment of pupil diameter to adaptation of the circadian clock. nonimage-forming responses are mediated by retinal ganglion cells expressing the photopigment melanopsin...
2017: NPJ Aging and Mechanisms of Disease
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