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Edward Cantu

Prashanth Vallabhajosyula, Laxminarayana Korutla, Andreas Habertheuer, Sanjana Reddy, Christian Schaufler, Jared Lasky, Joshua Diamond, Edward Cantu
BACKGROUND: Extracellular microvesicles (EVs) are being increasingly studied for their diagnostic potential. We investigated the feasibility of studying the kinetics and tissue-specific profiles of pulmonary EVs in the context of ex vivo lung perfusion (EVLP) used for salvaging marginal lungs for transplantation. METHODS: Perfusate from six marginal donor lungs placed on EVLP was collected at the following time points: 0, 10, and 60 minutes after and after perfusate exchange with Steen Solution; 120 and 180 minutes...
February 24, 2017: Annals of Thoracic Surgery
J M Diamond, E Cantu, M K Porteous, Y Suzuki, K C Meyer, D J Lederer, R K Milewski, S Arcasoy, F D'Ovidio, M Bacchetta, J R Sonett, G Singh, J Costa, J W Tobias, H Rodriguez, V M Van Deerlin, K M Olthoff, A Shaked, B-L Chang, J D Christie
Recipient responses to primary graft dysfunction (PGD) after lung transplantation may have important implications to the fate of the allograft. We therefore evaluated longitudinal differences in peripheral blood gene expression in subjects with PGD. RNA expression was measured throughout the first transplant year in 106 subjects enrolled in the Clinical Trials in Organ Transplantation-03 study using a panel of 100 hypothesis-driven genes. PGD was defined as grade 3 in the first 72 posttransplant hours. Eighteen genes were differentially expressed over the first year based on PGD development, with significant representation from innate and adaptive immunity genes, with most differences identified very early after transplant...
January 24, 2017: American Journal of Transplantation
Catherine F Borders, Yoshikazu Suzuki, Jared Lasky, Christian Schaufler, Djamila Mallem, James Lee, Kevin Carney, Scarlett L Bellamy, Christian A Bermudez, A Russell Localio, Jason D Christie, Joshua M Diamond, Edward Cantu
OBJECTIVE: Donor blood transfusion has been identified as a potential risk factor for primary graft dysfunction and by extension early mortality. We sought to define the contributing risk of donor transfusion on early mortality for lung transplant. METHODS: Donor and recipient data were abstracted from the Organ Procurement and Transplantation Network database updated through June 30, 2014, which included 86,398 potential donors and 16,255 transplants. Using the United Network for Organ Sharing 4-level designation of transfusion (no blood, 1-5 units, 6-10 units, and >10 units, massive), we analyzed all-cause mortality at 30-days with the use of logistic regression adjusted for confounders (ischemic time, donor age, recipient diagnosis, lung allocation score and recipient age, and recipient body mass index)...
May 2017: Journal of Thoracic and Cardiovascular Surgery
Mark F Powell, Charity J Morgan, Jessica A Cantu, Yasser Sakawi, Joseph R Biggio, Alan T N Tita, Jeff M Szychowski, Rodney K Edwards
Objective Our aims were to evaluate whether there is an inverse association between body mass index (BMI) and umbilical artery pH and to investigate the contribution of intraoperative hypotension on the umbilical artery pH. Study Design We conducted a retrospective cohort study of all women with a nonanomalous singleton at 37 to 41 weeks who underwent a scheduled cesarean delivery under spinal anesthesia at our facility from January 2006 to March 2012. The primary outcome was the proportion of patients in each BMI category with arterial cord pH < 7...
December 28, 2016: American Journal of Perinatology
B Knowles, C B Silveira, B A Bailey, K Barott, V A Cantu, A G Cobián-Güemes, F H Coutinho, E A Dinsdale, B Felts, K A Furby, E E George, K T Green, G B Gregoracci, A F Haas, J M Haggerty, E R Hester, N Hisakawa, L W Kelly, Y W Lim, M Little, A Luque, T McDole-Somera, K McNair, L S de Oliveira, S D Quistad, N L Robinett, E Sala, P Salamon, S E Sanchez, S Sandin, G G Z Silva, J Smith, C Sullivan, C Thompson, M J A Vermeij, M Youle, C Young, B Zgliczynski, R Brainard, R A Edwards, J Nulton, F Thompson, F Rohwer
No abstract text is available yet for this article.
November 3, 2016: Nature
J M Diamond, S Arcasoy, J A McDonnough, J R Sonett, M Bacchetta, F D'Ovidio, E Cantu, C A Bermudez, A McBurnie, M Rushefski, L H Kalman, M Oyster, C D'Errico, Y Suzuki, J T Giles, A Ferrante, M Lippel, G Singh, D J Lederer, J D Christie
Obesity is a risk factor for primary graft dysfunction (PGD), a form of lung injury resulting from ischemia-reperfusion after lung transplantation, but the impact of ischemia-reperfusion on adipose tissue is unknown. We evaluated differential gene expression in thoracic visceral adipose tissue (VAT) before and after lung reperfusion. Total RNA was isolated from thoracic VAT sampled from six subjects enrolled in the Lung Transplant Body Composition study before and after allograft reperfusion and quantified using the Human Gene 2...
January 2017: American Journal of Transplantation
Laurel A Monticelli, Michael D Buck, Anne-Laure Flamar, Steven A Saenz, Elia D Tait Wojno, Naomi A Yudanin, Lisa C Osborne, Matthew R Hepworth, Sara V Tran, Hans-Reimer Rodewald, Hardik Shah, Justin R Cross, Joshua M Diamond, Edward Cantu, Jason D Christie, Erika L Pearce, David Artis
Group 2 innate lymphoid cells (ILC2s) regulate tissue inflammation and repair after activation by cell-extrinsic factors such as host-derived cytokines. However, the cell-intrinsic metabolic pathways that control ILC2 function are undefined. Here we demonstrate that expression of the enzyme arginase-1 (Arg1) during acute or chronic lung inflammation is a conserved trait of mouse and human ILC2s. Deletion of mouse ILC-intrinsic Arg1 abrogated type 2 lung inflammation by restraining ILC2 proliferation and dampening cytokine production...
June 2016: Nature Immunology
Krista A McCoy, Alison M Roark, Ashley S P Boggs, John A Bowden, Lori Cruze, Thea M Edwards, Heather J Hamlin, Theresa M Cantu, Jessica A McCoy, Nicole A McNabb, Abby G Wenzel, Cameron E Williams, Satomi Kohno
Dr. Louis J. Guillette Jr. thought of himself as a reproductive biologist. However, his interest in reproductive biology transcended organ systems, life history stages, species, and environmental contexts. His integrative and collaborative nature led to diverse and fascinating research projects conducted all over the world. He doesn't leave us with a single legacy. Instead, he entrusts us with several. The purpose of this review is to highlight those legacies, in both breadth and diversity, and to illustrate Dr...
March 21, 2016: General and Comparative Endocrinology
J-Q Tao, E M Sorokina, J P Vazquez Medina, M K Mishra, Y Yamada, J Satalin, G F Nieman, J R Nellen, B Beduhn, E Cantu, N M Habashi, W Jungraithmayr, J D Christie, S Chatterjee
Lungs stored ahead of transplant surgery experience ischemia. Pulmonary ischemia differs from ischemia in the systemic organs in that stop of blood flow in the lung leads to loss of shear alone because the lung parenchyma does not rely on blood flow for its cellular oxygen requirements. Our earlier studies on the ischemia-induced mechanosignaling cascade showed that the pulmonary endothelium responds to stop of flow by production of reactive oxygen species (ROS). We hypothesized that ROS produced in this way led to induction of proinflammatory mediators...
September 2016: American Journal of Transplantation
B Knowles, C B Silveira, B A Bailey, K Barott, V A Cantu, A G Cobián-Güemes, F H Coutinho, E A Dinsdale, B Felts, K A Furby, E E George, K T Green, G B Gregoracci, A F Haas, J M Haggerty, E R Hester, N Hisakawa, L W Kelly, Y W Lim, M Little, A Luque, T McDole-Somera, K McNair, L S de Oliveira, S D Quistad, N L Robinett, E Sala, P Salamon, S E Sanchez, S Sandin, G G Z Silva, J Smith, C Sullivan, C Thompson, M J A Vermeij, M Youle, C Young, B Zgliczynski, R Brainard, R A Edwards, J Nulton, F Thompson, F Rohwer
Microbial viruses can control host abundances via density-dependent lytic predator-prey dynamics. Less clear is how temperate viruses, which coexist and replicate with their host, influence microbial communities. Here we show that virus-like particles are relatively less abundant at high host densities. This suggests suppressed lysis where established models predict lytic dynamics are favoured. Meta-analysis of published viral and microbial densities showed that this trend was widespread in diverse ecosystems ranging from soil to freshwater to human lungs...
March 24, 2016: Nature
Joshua M Diamond, Mary K Porteous, L Jackson Roberts, Nancy Wickersham, Melanie Rushefski, Steven M Kawut, Rupal J Shah, Edward Cantu, David J Lederer, Shampa Chatterjee, Vibha N Lama, Sangeeta Bhorade, Maria Crespo, John McDyer, Keith Wille, Jonathan Orens, Ann Weinacker, Selim Arcasoy, Pali D Shah, David S Wilkes, Chadi Hage, Scott M Palmer, Laurie Snyder, Carolyn S Calfee, Lorraine B Ware, Jason D Christie
BACKGROUND: Donor smoking history and higher fraction of inspired oxygen (FIO2) at reperfusion are associated with primary graft dysfunction (PGD) after lung transplantation. We hypothesized that oxidative injury biomarkers would be elevated in PGD, with higher levels associated with donor exposure to cigarette smoke and recipient hyperoxia at reperfusion. METHODS: We performed a nested case-control study of 72 lung transplant recipients from the Lung Transplant Outcomes Group cohort...
April 2016: Journal of Heart and Lung Transplantation
Rommel C Morales, Edward S M Bahnson, George E Havelka, Nadiezhda Cantu-Medellin, Eric E Kelley, Melina R Kibbe
BACKGROUND: Nitric oxide ((•)NO) is more effective at inhibiting neointimal hyperplasia following arterial injury in male versus female rodents, though the etiology is unclear. Given that superoxide (O2(•-)) regulates cellular proliferation, and (•)NO regulates superoxide dismutase-1 (SOD-1) in the vasculature, we hypothesized that (•)NO differentially regulates SOD-1 based on sex. MATERIALS AND METHODS: Male and female vascular smooth muscle cells (VSMC) were harvested from the aortae of Sprague-Dawley rats...
2015: Redox Biology
Edward S M Bahnson, Nathaniel Koo, Nadiezhda Cantu-Medellin, Aaron Y Tsui, George E Havelka, Janet M Vercammen, Qun Jiang, Eric E Kelley, Melina R Kibbe
Superoxide (O2(•-)) promotes neointimal hyperplasia following arterial injury. Conversely, nitric oxide ((•)NO) inhibits neointimal hyperplasia through various cell-specific mechanisms, including redox regulation. What remains unclear is whether (•)NO exerts cell-specific regulation of the vascular redox environment following arterial injury to inhibit neointimal hyperplasia. Therefore, the aim of the present study was to assess whether (•)NO exerts cell-specific, differential modulation of O2(•-) levels throughout the arterial wall, establish the mechanism of such modulation, and determine if it regulates (•)NO-dependent inhibition of neointimal hyperplasia...
January 30, 2015: Nitric Oxide: Biology and Chemistry
Edward Cantu, Rupal J Shah, Wei Lin, Zhongyin J Daye, Joshua M Diamond, Yoshikazu Suzuki, John H Ellis, Catherine F Borders, Gerald A Andah, Ben Beduhn, Nuala J Meyer, Melanie Ruschefski, Richard Aplenc, Rui Feng, Jason D Christie
OBJECTIVE: Oxidant stress pathway activation during ischemia reperfusion injury may contribute to the development of primary graft dysfunction (PGD) after lung transplantation. We hypothesized that oxidant stress gene variation in recipients and donors is associated with PGD. METHODS: Donors and recipients from the Lung Transplant Outcomes Group (LTOG) cohort were genotyped using the Illumina IBC chip filtered for oxidant stress pathway genes. Single nucleotide polymorphisms (SNPs) grouped into SNP sets based on haplotype blocks within 49 oxidant stress genes selected from gene ontology pathways and literature review were tested for PGD association using a sequencing kernel association test...
February 2015: Journal of Thoracic and Cardiovascular Surgery
Jessica Cantu, Jeff M Szychowski, Xuelin Li, Joseph Biggio, Rodney K Edwards, William Andrews, Alan T N Tita
OBJECTIVE: To assess the utility of umbilical cord venous blood gas measures for prediction of umbilical artery pH and base deficit acidemia. METHODS: A retrospective cohort study was conducted of all singletons with valid paired arterial and venous cord gas samples delivered at our institution from January 2006 to March 2012. Fetal acidemia was defined primarily as cord arterial blood gas pH less than 7.0. We also evaluated prediction of acidemia, defined as an arterial base deficit 12 mmol/L or greater...
November 2014: Obstetrics and Gynecology
Kyle Bittinger, Emily S Charlson, Elizabeth Loy, David J Shirley, Andrew R Haas, Alice Laughlin, Yanjie Yi, Gary D Wu, James D Lewis, Ian Frank, Edward Cantu, Joshua M Diamond, Jason D Christie, Ronald G Collman, Frederic D Bushman
BACKGROUND: Fungi are important pathogens but challenging to enumerate using next-generation sequencing because of low absolute abundance in many samples and high levels of fungal DNA from contaminating sources. RESULTS: Here, we analyze fungal lineages present in the human airway using an improved method for contamination filtering. We use DNA quantification data, which are routinely acquired during DNA library preparation, to annotate output sequence data, and improve the identification and filtering of contaminants...
2014: Genome Biology
Adi Abramovici, Victoria Jauk, Luisa Wetta, Jessica Cantu, Rodney Edwards, Joseph Biggio, Alan Tita
OBJECTIVE: We evaluated the relationship between aspirin supplementation and perinatal outcomes for potential effect modification by smoking status. STUDY DESIGN: A secondary analysis of two multicenter trials for which prophylactic aspirin supplementation was given to either low- or high-risk women for prevention of preeclampsia (PE). We examined the effect of aspirin by smoking status using the Breslow-Day test. Primary outcomes for this analysis were PE and preterm birth (PTB) < 37 weeks...
April 2015: American Journal of Perinatology
John Chaney, Yoshikazu Suzuki, Edward Cantu, Victor van Berkel
The criteria that define acceptable physiologic and social parameters for lung donation have remained constant since their empiric determination in the 1980s. These criteria include a donor age between 25-40, a arterial partial pressure of oxygen (PaO2)/FiO2 ratio greater than 350, no smoking history, a clear chest X-ray, clean bronchoscopy, and a minimal ischemic time. Due to the paucity of organ donors, and the increasing number of patients requiring lung transplant, finding a donor that meets all of these criteria is quite rare...
August 2014: Journal of Thoracic Disease
Jessica A Cantu, Victoria R Jauk, John Owen, Joseph R Biggio, Adi R Abramovici, Rodney K Edwards, Alan T Tita
OBJECTIVE: Late timing of intervention and maternal obesity are potential explanations for the modest effect of aspirin for preeclampsia prevention. We explored whether low-dose aspirin (LDA) is more effective in women at increased risk when initiated before 16 weeks' gestation or given to non-obese women. METHODS: Secondary analysis of a trial to evaluate LDA (60 mg/d) for preeclampsia prevention in high-risk women. Participants were randomized to LDA or placebo between 13 and 26 weeks...
July 2015: Journal of Maternal-fetal & Neonatal Medicine
David G Cohen, Jason D Christie, Brian J Anderson, Joshua M Diamond, Ryan P Judy, Rupal J Shah, Edward Cantu, Scarlett L Bellamy, Nancy P Blumenthal, Ejigayehu Demissie, Ramona O Hopkins, Mark E Mikkelsen
RATIONALE: Cognitive and psychiatric impairments are threats to functional independence, general health, and quality of life. Evidence regarding these outcomes after lung transplantation is limited. OBJECTIVES: Determine the frequency of cognitive and psychiatric impairment after lung transplantation and identify potential factors associated with cognitive impairment after lung transplantation. METHODS: In a retrospective cohort study, we assessed cognitive function, mental health, and health-related quality of life using a validated battery of standardized tests in 42 subjects post-transplantation...
May 2014: Annals of the American Thoracic Society
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