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https://www.readbyqxmd.com/read/28454292/dna-vaccine-encoding-human-papillomavirus-antigens-flanked-by-a-signal-peptide-and-a-kdel-sequence-induces-a-potent-therapeutic-antitumor-effect
#1
Jose J Perez-Trujillo, Rodolfo Garza-Morales, Jose A Barron-Cantu, Gabriel Figueroa-Parra, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha, Jaime Garcia-Juarez, Gerardo E Muñoz-Maldonado, Odila Saucedo-Cardenas, Roberto Montes-De-Oca-Luna, Maria De Jesus Loera-Arias
Cellular immune responses play a critical role in the eradication of intracellular infections and malignant cells through the recognition and subsequent removal of the infection or malignant cells. Effective antigen presentation is crucial for stimulating the immune system against malignant cells. Calreticulin (CRT) has been used to improve antigen presentation. However, CRT overexpression has been previously associated with the development of pancreatic and breast cancer. The import and retention signals of CRT in the endoplasmic reticulum (ER) can be used to overcome CRT overexpression...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28446457/consensus-statement-on-concussion-in-sport-the-5-th-international-conference-on-concussion-in-sport-held-in-berlin-october-2016
#2
Paul McCrory, Willem Meeuwisse, Jiří Dvorak, Mark Aubry, Julian Bailes, Steven Broglio, Robert C Cantu, David Cassidy, Ruben J Echemendia, Rudy J Castellani, Gavin A Davis, Richard Ellenbogen, Carolyn Emery, Lars Engebretsen, Nina Feddermann-Demont, Christopher C Giza, Kevin M Guskiewicz, Stanley Herring, Grant L Iverson, Karen M Johnston, James Kissick, Jeffrey Kutcher, John J Leddy, David Maddocks, Michael Makdissi, Geoff Manley, Michael McCrea, William P Meehan, Sinji Nagahiro, Jon Patricios, Margot Putukian, Kathryn J Schneider, Allen Sills, Charles H Tator, Michael Turner, Pieter E Vos
No abstract text is available yet for this article.
April 26, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28420878/synergistic-antimicrobial-effects-of-silver-transition-metal-combinatorial-treatments
#3
Javier A Garza-Cervantes, Arturo Chávez-Reyes, Elena C Castillo, Gerardo García-Rivas, Oscar Antonio Ortega-Rivera, Eva Salinas, Margarita Ortiz-Martínez, Sara Leticia Gómez-Flores, Jorge A Peña-Martínez, Alan Pepi-Molina, Mario T Treviño-González, Xristo Zarate, María Elena Cantú-Cárdenas, Carlos Enrique Escarcega-Gonzalez, J Rubén Morones-Ramírez
Due to the emergence of multi-drug resistant strains, development of novel antibiotics has become a critical issue. One promising approach is the use of transition metals, since they exhibit rapid and significant toxicity, at low concentrations, in prokaryotic cells. Nevertheless, one main drawback of transition metals is their toxicity in eukaryotic cells. Here, we show that the barriers to use them as therapeutic agents could be mitigated by combining them with silver. We demonstrate that synergism of combinatorial treatments (Silver/transition metals, including Zn, Co, Cd, Ni, and Cu) increases up to 8-fold their antimicrobial effect, when compared to their individual effects, against E...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28338755/red-blotch-disease-alters-grape-berry-development-and-metabolism-by-interfering-with-the-transcriptional-and-hormonal-regulation-of-ripening
#4
Barbara Blanco-Ulate, Helene Hopfer, Rosa Figueroa-Balderas, Zirou Ye, Rosa M Rivero, Alfonso Albacete, Francisco Pérez-Alfocea, Renata Koyama, Michael M Anderson, Rhonda J Smith, Susan E Ebeler, Dario Cantu
Grapevine red blotch-associated virus (GRBaV) is a major threat to the wine industry in the USA. GRBaV infections (aka red blotch disease) compromise crop yield and berry chemical composition, affecting the flavor and aroma properties of must and wine. In this study, we combined genome-wide transcriptional profiling with targeted metabolite analyses and biochemical assays to characterize the impact of the disease on red-skinned berry ripening and metabolism. Using naturally infected berries collected from two vineyards, we were able to identify consistent berry responses to GRBaV across different environmental and cultural conditions...
February 1, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28264907/increased-pilus-production-conferred-by-a-naturally-occurring-mutation-alters-host-pathogen-interaction-in-favor-of-carriage-in-streptococcus-pyogenes
#5
Anthony R Flores, Randall J Olsen, Concepcion Cantu, Kyler B Pallister, Fermin E Guerra, Jovanka M Voyich, James M Musser
Studies of the human pathogen group A Streptococcus (GAS) define the carrier phenotype as increased ability to adhere to and persist on epithelial surfaces and decreased ability to cause disease. We tested the hypothesis that a single amino acid change (Arg135Gly) in a highly conserved sensor kinase (LiaS) of a poorly defined GAS regulatory system contributes to a carrier phenotype through increased pilus production. When introduced into an emm serotype-matched invasive strain, the carrier allele (liaS(R135G)) recapitulated a carrier phenotype defined by increased ability to adhere to mucosal surfaces and decreased ability to cause disease...
March 6, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28229128/repetitive-head-impact-exposure-and-later-life-plasma-total-tau-in-former-national-football-league-players
#6
Michael L Alosco, Yorghos Tripodis, Johnny Jarnagin, Christine M Baugh, Brett Martin, Christine E Chaisson, Nate Estochen, Linan Song, Robert C Cantu, Andreas Jeromin, Robert A Stern
INTRODUCTION: Blood protein analysis of total tau (t-tau) may be a practical screening biomarker for chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy associated with repetitive head impact (RHI) exposure. We examined plasma t-tau in symptomatic former National Football League (NFL) players compared with controls and the relationship between RHI exposure and later-life plasma t-tau. METHODS: Ninety-six former NFL players (age 40-69) and 25 same-age controls underwent blood draw to determine plasma t-tau levels...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28222261/enhanced-release-of-molecules-upon-uv-light-irradiation-from-photoresponsive-hydrogels-prepared-from-bifunctional-azobenzene-and-four-arm-poly-ethylene-glycol
#7
Shiva Kumar Rastogi, Hailee E Anderson, Joseph Lamas, Scott L Barrett, Travis Cantu, Stefan Zauscher, William J Brittain, Tania Betancourt
Advances in biosensors and drug delivery depend on hydrogels that respond to external stimuli. In this work we de-scribe the preparation and characterization of photoresponsive hydrogels prepared by crosslinking of di-NHS ester of azobenzoic acid and four-armed, amine-terminated poly(ethylene glycol). The porous structure and composition of the hydrogels were confirmed by scanning electron microscopy and Fourier transform infrared (FTIR) spectroscopy. The reversible photoisomerization of the azobenzene-containing hydrogel crosslinkers in the gels was confirmed by ab-sorption spectroscopy...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28219109/the-use-of-braf-v600e-mutation-specific-immunohistochemistry-in-pediatric-langerhans-cell-histiocytosis
#8
Leomar Y Ballester, Miguel D Cantu, Karen P H Lim, Stephen F Sarabia, Lizmery Suarez Ferguson, C Renee Webb, Carl E Allen, Kenneth L McClain, Carrie A Mohila, Jyotinder N Punia, Angshumoy Roy, Dolores H López-Terrada, M John Hicks, Kevin E Fisher
BRAF p.V600E mutations are detected in greater than 50% of pediatric Langerhans cell histiocytosis (LCH) lesions. However, the use of mutation-specific BRAF V600E immunohistochemistry (IHC) as a surrogate for molecular testing in pediatric LCH is unknown. We tested the mutation-specific BRAF V600E monoclonal antibody (clone VE1) in formalin-fixed, paraffin-embedded LCH samples from 26 pediatric patients (14 males and 12 females, ages 7 mo-17 y) using allele-specific real-time polymerase chain reaction (PCR) with a limit of detection of 0...
February 20, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28218463/closed-reference-metatranscriptomics-enables-in-planta-profiling-of-putative-virulence-activities-in-the-grapevine-trunk-disease-complex
#9
Abraham Morales-Cruz, Gabrielle Allenbeck, Rosa Figueroa-Balderas, Vanessa E Ashworth, Daniel P Lawrence, Renaud Travadon, Rhonda J Smith, Kendra Baumgartner, Philippe E Rolshausen, Dario Cantu
Grapevines, like other perennial crops, are affected by so-called 'trunk diseases', which damage the trunk and other woody tissues. Mature grapevines typically contract more than one trunk disease and often multiple grapevine trunk pathogens (GTPs) are recovered from infected tissues. The co-existence of different GTP species in complex and dynamic microbial communities complicates the study of the molecular mechanisms underlying disease development especially under vineyard conditions. The objective of this study was to develop and optimize a community-level transcriptomics (i...
February 20, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/28038736/-bone-cement-implant-as-an-alternative-for-orbital-floor-reconstruction-a-case-report
#10
Enrique Vargas-Solalinde, Marisol E Huichapa-Padilla, Daniel Garza-Cantú, Víctor H Reyna-Martínez, Julio Alatorre-Ricardo, Juan Luis González-Treviño
BACKGROUND: The management of orbitary fractures is one of the most challenging in facial trauma; the variety of reconstruction materials for its treatment is broad and is constantly improving, but despite this there is no consensus for its use or literature that sustains it. OBJECTIVE: To present the use and design of a preformed bone implant as an alternative for the reconstruction of orbital floor fractures in the pediatric age group. CLINICAL CASE: A 7-year old male who suffered a right hemifacial contusion trauma with clinical and tomographic diagnosis of right pure blowout type orbital floor fracture with inferior rectus muscle entrapment and right post-traumatic palpebral ptosis...
December 27, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27989783/the-binding-effectiveness-of-anti-r-disintegrin-polyclonal-antibodies-against-disintegrins-and-pii-and-piii-metalloproteases-an-immunological-survey-of-type-a-b-and-a-b-venoms-from-mohave-rattlesnakes
#11
Esteban Cantú, Sahiti Mallela, Matthew Nyguen, Raúl Báez, Victoria Parra, Rachel Johnson, Kyle Wilson, Montamas Suntravat, Sara Lucena, Alexis Rodríguez-Acosta, Elda E Sánchez
Snake venoms are known to have different venom compositions and toxicity, but differences can also be found within populations of the same species contributing to the complexity of treatment of envenomated victims. One of the first well-documented intraspecies venom variations comes from the Mohave rattlesnake (Crotalus scutulatus scutulatus). Initially, three types of venoms were described; type A venom is the most toxic as a result of ~45% Mojave toxin in the venom composition, type B lacks the Mojave toxin but contains over 50% of snake venom metalloproteases (SVMPs)...
January 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/27958762/cd47-and-nox1-mediate-dynamic-fluid-phase-macropinocytosis-of-native-ldl
#12
Gábor Csányi, Douglas M Feck, Pushpankur Ghoshal, Bhupesh Singla, Huiping Lin, Shanmugam Nagarajan, Daniel N Meijles, Imad Al Ghouleh, Nadiezhda Cantu-Medellin, Eric E Kelley, Lukasz Mateuszuk, Jeffrey S Isenberg, Simon Watkins, Patrick J Pagano
AIMS: Macropinocytosis has been implicated in cardiovascular and other disorders, yet physiological factors that initiate fluid-phase internalization and the signaling mechanisms involved remain poorly identified. The present study was designed to examine whether matrix protein thrombospondin-1 (TSP1) stimulates macrophage macropinocytosis and, if so, to investigate the potential signaling mechanism involved. RESULTS: TSP1 treatment of human and murine macrophages stimulated membrane ruffle formation and pericellular solute internalization by macropinocytosis...
January 31, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/27731934/the-perioperative-lung-transplant-virome-torque-teno-viruses-are-elevated-in-donor-lungs-and-show-divergent-dynamics-in-primary-graft-dysfunction
#13
A A Abbas, J M Diamond, C Chehoud, B Chang, J J Kotzin, J C Young, I Imai, A R Haas, E Cantu, D J Lederer, K C Meyer, R K Milewski, K M Olthoff, A Shaked, J D Christie, F D Bushman, R G Collman
Primary graft dysfunction (PGD) is a principal cause of early morbidity and mortality after lung transplantation, but its pathogenic mechanisms are not fully clarified. To date, studies using standard clinical assays have not linked microbial factors to PGD. We previously used comprehensive metagenomic methods to characterize viruses in lung allografts >1 mo after transplant and found that levels of Anellovirus, mainly torque teno viruses (TTVs), were significantly higher than in nontransplanted healthy controls...
May 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/27680385/development-of-a-teen-focused-exergame
#14
Debbe Thompson, Dora Cantu, Madhur Rajendran, Mayur Rajendran, Tanay Bhargava, Yuting Zhang, Cheng Chen, Yan Liu, Zhigang Deng
INTRODUCTION: Exergames require body movement to play and may be an effective method for enhancing teen physical activity (PA). However, results have been mixed. Innovative methods are needed to develop Exergames that increase and maintain PA. Self-representational avatars, or avatars created from a digital image of an individual, may increase PA (e.g., intensity, duration) during Exergame play. This article addresses this novel idea by describing the development of an Exergame played with a self-representational avatar...
September 28, 2016: Games for Health
https://www.readbyqxmd.com/read/27676441/cerebral-18-%C3%A2-f-t807-av1451-retention-pattern-in-clinically-probable-cte-resembles-pathognomonic-distribution-of-cte-tauopathy
#15
D L Dickstein, M Y Pullman, C Fernandez, J A Short, L Kostakoglu, K Knesaurek, L Soleimani, B D Jordan, W A Gordon, K Dams-O'Connor, B N Delman, E Wong, C Y Tang, S T DeKosky, J R Stone, R C Cantu, M Sano, P R Hof, S Gandy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder most commonly associated with repetitive traumatic brain injury (TBI) and characterized by the presence of neurofibrillary tangles of tau protein, known as a tauopathy. Currently, the diagnosis of CTE can only be definitively established postmortem. However, a new positron emission tomography (PET) ligand, [(18)F]T807/AV1451, may provide the antemortem detection of tau aggregates, and thus various tauopathies, including CTE. Our goal was to examine [(18)F]T807/AV1451 retention in athletes with neuropsychiatric symptoms associated with a history of multiple concussions...
September 27, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27673121/poster-370-an-international-observational-study-of-botulinum-toxin-type-a-in-spasticity-spasticity-in-practice-space
#16
Jörg Wissel, Julian P Harriss, Olivier Simon, Kati Sternberg, Nicolas Roche, Carlos Cantú-Brito, Svetlana E Khatkova, Patrik Säterö
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27669010/neospora-caninum-in-axis-deer-axis-axis-and-fallow-deer-dama-dama-in-northern-mexico
#17
Jose R De La Torre, Christian Bautista-Piña, J Alfonso Ortega-S, Antonio Cantu-Covarruvias, Maria Genoveva Alvarez-Ojeda, Dora Romero-Salas, Scott E Henke, Clayton D Hilton, David G Hewitt, Randy W De Young, Tyler A Campbell, Fred C Bryant
Serum samples from 18 axis deer ( Axis axis ) and 19 fallow deer ( Dama dama ) were analyzed with an enzyme-linked immunosorbent assay for Neospora caninum antibodies. Two axis (11%) and two fallow deer (11%) were positive for N. caninum antibodies.
January 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/27608499/biogas-production-from-the-mechanically-pretreated-liquid-fraction-of-sorted-organic-municipal-solid-wastes
#18
A Alvarado-Lassman, J M Méndez-Contreras, A Martínez-Sibaja, E S Rosas-Mendoza, N A Vallejo-Cantú
The high liquid content in fruit and vegetable wastes makes it convenient to mechanically separate these wastes into mostly liquid and solid fractions by means of pretreatment. Then, the liquid fraction can be treated using a high-rate anaerobic biofilm reactor to produce biogas, simultaneously reducing the amount of solids that must be landfilled. In this work, the specific composition of municipal solid waste (MSW) in a public market was determined; then, the sorted organic fraction of municipal solid waste was treated mechanically to separate and characterize the mostly liquid and solid fractions...
September 13, 2016: Environmental Technology
https://www.readbyqxmd.com/read/27595565/hemi-methylated-dna-regulates-dna-methylation-inheritance-through-allosteric-activation-of-h3-ubiquitylation-by-uhrf1
#19
Joseph S Harrison, Evan M Cornett, Dennis Goldfarb, Paul A DaRosa, Zimeng M Li, Feng Yan, Bradley M Dickson, Angela H Guo, Daniel V Cantu, Lilia Kaustov, Peter J Brown, Cheryl H Arrowsmith, Dorothy A Erie, Michael B Major, Rachel E Klevit, Krzysztof Krajewski, Brian Kuhlman, Brian D Strahl, Scott B Rothbart
The epigenetic inheritance of DNA methylation requires UHRF1, a histone- and DNA-binding RING E3 ubiquitin ligase that recruits DNMT1 to sites of newly replicated DNA through ubiquitylation of histone H3. UHRF1 binds DNA with selectivity towards hemi-methylated CpGs (HeDNA); however, the contribution of HeDNA sensing to UHRF1 function remains elusive. Here, we reveal that the interaction of UHRF1 with HeDNA is required for DNA methylation but is dispensable for chromatin interaction, which is governed by reciprocal positive cooperativity between the UHRF1 histone- and DNA-binding domains...
September 6, 2016: ELife
https://www.readbyqxmd.com/read/27556939/corrigendum-lytic-to-temperate-switching-of-viral-communities
#20
B Knowles, C B Silveira, B A Bailey, K Barott, V A Cantu, A G Cobián-Güemes, F H Coutinho, E A Dinsdale, B Felts, K A Furby, E E George, K T Green, G B Gregoracci, A F Haas, J M Haggerty, E R Hester, N Hisakawa, L W Kelly, Y W Lim, M Little, A Luque, T McDole-Somera, K McNair, L S de Oliveira, S D Quistad, N L Robinett, E Sala, P Salamon, S E Sanchez, S Sandin, G G Z Silva, J Smith, C Sullivan, C Thompson, M J A Vermeij, M Youle, C Young, B Zgliczynski, R Brainard, R A Edwards, J Nulton, F Thompson, F Rohwer
No abstract text is available yet for this article.
November 3, 2016: Nature
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