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Christian Bermudez

Alexander C Schwed, Monica M Boggs, Xuan-Binh D Pham, Drew M Watanabe, Michael C Bermudez, Amy H Kaji, Dennis Y Kim, David S Plurad, Darin J Saltzman, Christian de Virgilio
Importance: Acute cholangitis (AC), particularly severe AC, has historically required urgent endoscopic decompression, although the timing of decompression is controversial. We previously identified 2 admission risk factors for adverse outcomes in AC: total bilirubin level greater than 10 mg/dL and white blood cell count greater than 20 000 cells/µL. Objectives: To validate previously identified prognostic factors in AC, evaluate the effect of timing of endoscopic retrograde cholangiopancreatography on clinical outcomes, and compare recent experience with AC vs an historical cohort...
August 24, 2016: JAMA Surgery
Joshua M Diamond, Selim Arcasoy, Jamiela A McDonnough, Joshua R Sonett, Matthew Bacchetta, Frank D'Ovidio, Edward Cantu, Christian A Bermudez, Amika McBurnie, Melanie Rushefski, Laurel H Kalman, Michelle Oyster, Carly D'Errico, Yoshikazu Suzuki, Jon T Giles, Anthony Ferrante, Matthew Lippel, Gopal Singh, David J Lederer, Jason D Christie
Obesity is a risk factor for primary graft dysfunction, a form of lung injury resulting from ischemia reperfusion after lung transplantation, but the impact of ischemia reperfusion on adipose tissue is unknown. We evaluated differential gene expression in thoracic visceral adipose tissue (VAT) before and after lung reperfusion. Total RNA was isolated from thoracic VAT sampled from 6 subjects enrolled in the Lung Transplant Body Composition study before and after allograft reperfusion and quantified using the Human Gene 2...
July 16, 2016: American Journal of Transplantation
Christiane Düttmann, Byron Flores, Nathaniel Kadoch Z, Sergio Bermúdez C
We document the species of ticks that parasitize livestock in Nicaragua. The study was based on tick collection on cattle and horses from 437 farms in nine departments. Of 4841 animals examined (4481 cows and 360 horses), 3299 were parasitized, which represent 68 % of the bovines and 67 % of the equines in study: 59 cows and 25 horses were parasitized by more than one species. In addition, 280 specimens of the entomological museum in León were examined. The ticks found on cattle were Rhipicephalus microplus (75...
September 2016: Experimental & Applied Acarology
Josephine Chou, Christian Bermudez, Robert Kormos, Jeffrey Teuteberg
Cardiogenic shock complicating acute myocardial infarctions (CS-AMI) carries high mortality rates. Early use of durable continuous flow left ventricular assist devices (CF-LVAD) in these patients has traditionally been discouraged. Therefore we sought to assess the efficacy and complications of CF-LVAD use in CS-AMI after stabilization with temporary mechanical support. From January 2006 to November 2014, 9 patients underwent CF-LVAD implant after CS-AMI (Heartmate II, six; HVAD, three). All patients required temporary mechanical circulatory support prior to CF-LVAD implant and were INTERMACS profile 1; average time from MI to CF-LVAD implant was 20 days...
June 1, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Alex M D'Angelo, Ernest G Chan, J W Awori Hayanga, David D Odell, Joseph Pilewski, Maria Crespo, Matthew Morrell, Norihisa Shigemura, James Luketich, Christian Bermudez, Andrew D Althouse, Jonathan D'Cunha
OBJECTIVES: Atrial arrhythmia (AA) after lung transplantation (LTx) is a potentially morbid event often associated with increased length of hospital stay. Predictors of postsurgical AA, however, are incompletely understood. We characterized the incidence and predisposing risk factors for AA in patients undergoing LTx. METHODS: A retrospective analysis of prospectively collected data was conducted to identify LTx recipients between January 2008 and October 2013. Patients were divided into 2 groups on the basis of postoperative AA development...
September 2016: Journal of Thoracic and Cardiovascular Surgery
Elena Taverna, Felipe Mora-Bermúdez, Paulina J Strzyz, Marta Florio, Jaroslav Icha, Christiane Haffner, Caren Norden, Michaela Wilsch-Bräuninger, Wieland B Huttner
Apical radial glia (aRG), the stem cells in developing neocortex, are unique bipolar epithelial cells, extending an apical process to the ventricle and a basal process to the basal lamina. Here, we report novel features of the Golgi apparatus, a central organelle for cell polarity, in mouse aRGs. The Golgi was confined to the apical process but not associated with apical centrosome(s). In contrast, in aRG-derived, delaminating basal progenitors that lose apical polarity, the Golgi became pericentrosomal. The aRG Golgi underwent evolutionarily conserved, accordion-like compression and extension concomitant with cell cycle-dependent nuclear migration...
2016: Scientific Reports
Balakrishnan Mahesh, Jay K Bhama, David D Odell, Awori J Hayanga, Christian A Bermudez, Matthew R Morrell, Maria M Crespo, Joseph M Pilewski, Bruce A Johnson, James D Luketich, Jonathan D'Cunha, Norihisa Shigemura
BACKGROUND: Adult lung transplant recipients with small chests have traditionally received lungs from pediatric donors, placing an additional strain on the already restricted pediatric donor pool. Performing lobar lung transplantation (LLT) can circumvent issues with donor-recipient size mismatch; however, LLT imparts additional risks. Here, we review our experience using LLT and standard lung transplantation using a pediatric donor (PDLT) for adults with small chests. METHODS: We retrospectively reviewed consecutive patients with end-stage lung disease and a height of 65 inches or less who underwent LLT (n = 15) or PDLT (n = 15) between 2006 and 2012 at our institution, a high-volume lung transplant center...
January 12, 2016: Transplantation
Fenton H McCarthy, Katherine M McDermott, Vinay Kini, Jacob T Gutsche, Joyce W Wald, Dawei Xie, Wilson Y Szeto, Christian A Bermudez, Pavan Atluri, Michael A Acker, Nimesh D Desai
This study evaluates contemporary trends in the use and outcomes of adult patients undergoing extracorporeal membrane oxygenation (ECMO) in U.S. hospitals. All adult discharges in the Nationwide Inpatient Sample database during the years 2002-2012 that included ECMO were used to estimate the total number of U.S. ECMO hospitalizations (n = 12,407). Diagnostic codes were used to group patients by indication for ECMO use into postcardiotomy, heart transplant, lung transplant, cardiogenic shock, respiratory failure, and cardiopulmonary failure...
2015: Seminars in Thoracic and Cardiovascular Surgery
Christian A Bermudez, Diana Zaldonis, Ming-Hui Fan, Joseph M Pilewski, Maria M Crespo
Although extracorporeal membrane oxygenation (ECMO) has been used frequently as a bridge to primary lung transplantation, active centers are conservative with this approach in patients requiring redo lung transplantation. We report the use of extracorporeal carbon dioxide removal, using the Hemolung respiratory assist system, as a prolonged bridge to lung transplantation, and the first use of the Hemolung as a bridge to redo lung transplantation. Hemolung support improved the patient's clinical status and allowed redo lung transplantation...
December 2015: Annals of Thoracic Surgery
Matthew A Tucker, J D Adams, Lemuel A Brown, Christian B Ridings, Jenna M Burchfield, Forrest B Robinson, Jamie L McDermott, Brett A Schreiber, Nicole E Moyen, Tyrone A Washington, Andrea C Bermudez, Meredith P Bennett, Maxime E Buyckx, Matthew S Ganio
PURPOSE: To investigate changes in 24-hour hydration status when increasing fluid intake. METHODS: Thirty-five healthy males (age 23.8 ± 4.7 years; mass 74.0 ± 9.4 kg) were divided into 4 treatment groups for 2 weeks of testing. Volumes of 24-hour fluid ingestion (including water from food) for weeks 1 and 2 was 35 and 40 ml/kg body mass, respectively. Each treatment group was given the same proportion of beverages in each week of testing: water only (n = 10), water + caloric cola (n = 7), water + noncaloric cola (n = 10), or water + caloric cola + noncaloric cola + orange juice (n = 8)...
May 2016: Journal of the American College of Nutrition
Christian A Bermudez, J Eduardo Rame
No abstract text is available yet for this article.
November 2015: Journal of Thoracic and Cardiovascular Surgery
Jenna Zaldonis, Mohammad Alrawashdeh, Kathryn S Atman, Angela Fatigati, Annette DeVito Dabbs, Christian A Bermudez
Context-Lung transplant recipients are encouraged to perform self-management behaviors to maximize health outcomes; however, performance is often less than ideal. Goal orientation is known to influence achievement of academic goals, but the influence of goal orientation on performance of self-management is unknown. Objectives-To identify characteristics at transplant that are predictive of higher goal orientation and examine relationships between Goal Orientation Index (GOI) subscores (Acting, Planning, Reflecting), self-management behaviors (adhering, self-monitoring, and communicating critical changes), and health-related quality of life (HRQOL) at 1 year after transplant...
September 2015: Progress in Transplantation
Fong Kuan Wong, Ji-Feng Fei, Felipe Mora-Bermúdez, Elena Taverna, Christiane Haffner, Jun Fu, Konstantinos Anastassiadis, A Francis Stewart, Wieland B Huttner
The evolutionary expansion of the neocortex in mammals has been linked to enlargement of the subventricular zone (SVZ) and increased proliferative capacity of basal progenitors (BPs), notably basal radial glia (bRG). The transcription factor Pax6 is known to be highly expressed in primate, but not mouse, BPs. Here, we demonstrate that sustaining Pax6 expression selectively in BP-genic apical radial glia (aRG) and their BP progeny of embryonic mouse neocortex suffices to induce primate-like progenitor behaviour...
August 2015: PLoS Biology
Emily M Rosenberger, Andrea F DiMartini, Annette J DeVito Dabbs, Christian A Bermudez, Joseph M Pilewski, Yoshiya Toyoda, Mary Amanda Dew
BACKGROUND: Long-term survival after lung transplantation remains poor, yet modifiable risk factors for late-term morbidity and mortality have yet to be identified. Because psychiatric disorders increase risk for poor health outcomes in many nontransplant chronic disease populations, lung recipients with depression or anxiety before or early after transplantation may be at heightened risk for late-term transplant-related morbidity and mortality. METHODS: Among 178 patients from a prospective study of mental health after lung transplantation, we identified 1-year survivors and examined whether they experienced major depression or anxiety disorders during that year as well as before transplantation...
January 2016: Transplantation
Indira Medina, Céline Cougoule, Maik Drechsler, Beatriz Bermudez, Rory R Koenen, Judith Sluimer, Ine Wolfs, Yvonne Döring, Veronica Herias, Marjon Gijbels, Ilze Bot, Saskia C A de Jager, Christian Weber, Jack Cleutjens, Theo J C van Berkel, Kees-Jan Sikkink, Atilla Mócsai, Isabelle Maridonneau-Parini, Oliver Soehnlein, Erik A L Biessen
BACKGROUND: Leukocyte migration is critical for the infiltration of monocytes and accumulation of monocyte-derived macrophages in inflammation. Considering that Hck and Fgr are instrumental in this process, their impact on atherosclerosis and on lesion inflammation and stability was evaluated. METHODS AND RESULTS: Hematopoietic Hck/Fgr-deficient, LDLr(-/-) chimeras, obtained by bone marrow transplantation, had smaller but, paradoxically, less stable lesions with reduced macrophage content, overt cap thinning, and necrotic core expansion as the most prominent features...
August 11, 2015: Circulation
Miriam Bermudez-Brito, Christiane Rösch, Henk A Schols, Marijke M Faas, Paul de Vos
SCOPE: Main objectives of this study were (1) to demonstrate direct signaling of starch on human dendritic cells (DCs), (2) to study whether this is mediated by the pattern recognition receptors such as Toll-like receptors (TLRs) and (3) to study whether intestinal epithelial cells (IECs) are involved in modulating the starch induced immune activation of DCs. METHODS AND RESULTS: Two different types of resistant starch, High-maize® 260 (RS2) and Novelose® 330 (RS3) were characterized for their starch content and particle size...
September 2015: Molecular Nutrition & Food Research
Matthew A Tucker, Matthew S Ganio, J D Adams, Lemuel A Brown, Christian B Ridings, Jenna M Burchfield, Forrest B Robinson, Jamie L McDermott, Brett A Schreiber, Nicole E Moyen, Tyrone A Washington, Andrea C Bermudez, Meredith P Bennett, Maxime E Buyckx
OBJECTIVE: To investigate the 24-h hydration status of healthy, free-living, adult males when given various combinations of different beverage types. METHODS: Thirty-four healthy adult males participated in a randomized, repeated-measures design in which they consumed: water only (treatment A), water+cola (treatment B), water+diet cola (treatment C), or water+cola+diet cola+orange juice (treatment D) over a sedentary 24-h period across four weeks of testing. Volumes of fluid were split evenly between beverages within each treatment, and when accounting for food moisture content and metabolic water production, total fluid intake from all sources was equal to 35 ± 1 ml/kg body mass...
2015: Journal of the American College of Nutrition
Stephen A Esper, Christian Bermudez, Eric J Dueweke, Robert Kormos, Kathirvel Subramaniam, Suresh Mulukutla, Penny Sappington, Jonathan Waters, Sameer J Khandhar
BACKGROUND: Acute coronary syndrome (ACS) complicated by shock is associated with high mortality despite the use of percutaneous support devices. Extracorporeal membrane oxygenation (ECMO) offers cardiopulmonary support but its safety and efficacy in the ACS setting is still under investigation. METHODS: We reviewed the clinical characteristics and course of 18 consecutive patients who received femoral veno-arterial ECMO in the cardiac catheterization lab for severe shock due to ACS at our center between 2007 and 2013...
October 2015: Catheterization and Cardiovascular Interventions
Miriam Bermudez-Brito, Neha M Sahasrabudhe, Christiane Rösch, Henk A Schols, Marijke M Faas, Paul de Vos
SCOPE: In the present study, the direct interaction of commonly consumed fibers with epithelial or dendritic cells (DCs) was studied. METHODS AND RESULTS: The fibers were characterized for their sugar composition and chain length profile. When in direct contact, fibers activate DCs only mildly. This was different when DCs and fibers were co-cultured together with supernatants from human epithelial cells (Caco spent medium). Caco spent medium enhanced the production of IL-12, IL-1Ra, IL-6, IL-8, TNF-α, MCP-1 (monocyte chemotactic protein), and MIP-1α but this was strongly attenuated by the dietary fibers...
April 2015: Molecular Nutrition & Food Research
Alex D'Angelo, Jay K Bhama, Maria Crespo, Joseph Pilewski, Norihisa Shigemura, Christian Bermudez, James D Luketich, Jonathan D'Cunha
No abstract text is available yet for this article.
April 2015: Journal of Thoracic and Cardiovascular Surgery
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