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https://www.readbyqxmd.com/read/28213374/diurnal-differences-in-risk-of-cardiac-arrhythmias-during-spontaneous-hypoglycemia-in-young-people-with-type-1-diabetes
#1
Peter Novodvorsky, Alan Bernjak, Elaine Chow, Ahmed Iqbal, Lianne Sellors, Scott Williams, Robert A Fawdry, Bhavin Parekh, Richard M Jacques, Jefferson L B Marques, Paul J Sheridan, Simon R Heller
OBJECTIVE: Hypoglycemia may exert proarrhythmogenic effects on the heart via sympathoadrenal stimulation and hypokalemia. Hypoglycemia-induced cardiac dysrhythmias are linked to the "dead-in-bed syndrome," a rare, but devastating, condition. We examined the effect of nocturnal and daytime clinical hypoglycemia on electrocardiogram (ECG) in young people with type 1 diabetes. RESEARCH DESIGN AND METHODS: Thirty-seven individuals with type 1 diabetes underwent 96 h of simultaneous ambulatory ECG and blinded continuous interstitial glucose monitoring (CGM) while symptomatic hypoglycemia was recorded...
February 17, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28192777/renal-function-and-scaled-troponin-in-patients-presenting-to-the-emergency-department-with-symptoms-of-myocardial-infarction
#2
Anupama Vasudevan, Adam J Singer, Christopher DeFilippi, Gary Headden, Jeffrey M Schussler, Lori B Daniels, Michael Reed, Martin P Than, Robert Birkhahn, Stephen W Smith, Tyler W Barrett, William Arnold, W Frank Peacock, Peter A McCullough
BACKGROUND: Cardiac troponins are often found to be elevated in patients with renal dysfunction, even in the absence of acute myocardial injury. The objective of this report was to characterize the scaled troponin values and proportion of adjudicated acute myocardial infarction (AMI) among patients with and without renal dysfunction. METHODS: The data was from a multicenter prospective study including patients presenting to the emergency department with symptoms of AMI...
February 14, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28191886/sirtuin-1-regulates-cardiac-electrical-activity-by-deacetylating-the-cardiac-sodium-channel
#3
Ajit Vikram, Christopher M Lewarchik, Jin-Young Yoon, Asma Naqvi, Santosh Kumar, Gina M Morgan, Julia S Jacobs, Qiuxia Li, Young-Rae Kim, Modar Kassan, Jing Liu, Mohanad Gabani, Ajay Kumar, Haider Mehdi, Xiaodong Zhu, Xiaoqun Guan, William Kutschke, Xiaoming Zhang, Ryan L Boudreau, Shengchuan Dai, Daniel S Matasic, Saet-Byel Jung, Kenneth B Margulies, Vikas Kumar, Markus M Bachschmid, Barry London, Kaikobad Irani
The voltage-gated cardiac Na(+) channel (Nav1.5), encoded by the SCN5A gene, conducts the inward depolarizing cardiac Na(+) current (INa) and is vital for normal cardiac electrical activity. Inherited loss-of-function mutations in SCN5A lead to defects in the generation and conduction of the cardiac electrical impulse and are associated with various arrhythmia phenotypes. Here we show that sirtuin 1 deacetylase (Sirt1) deacetylates Nav1.5 at lysine 1479 (K1479) and stimulates INa via lysine-deacetylation-mediated trafficking of Nav1...
February 13, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28190549/comparing-del-nido-and-conventional-cardioplegia-in-infants-and-neonates-in-congenital-heart-surgery
#4
Kamal K Pourmoghadam, Mark Ruzmetov, Michael C O'Brien, Kurt D Piggott, Gary Plancher, Sukumar Suguna Narasimhulu, Tavya Benjamin, William M Decampli
BACKGROUND: The aim of this study was to evaluate outcome measures after the use of del Nido (dN) cardioplegia compared with conventional multidose high-potassium (non-dN) cardioplegia in neonates and infants. METHODS: We retrospectively analyzed data in patients, aged younger than 1 year, undergoing cardiopulmonary bypass (CPB) from January 2012 to August 2015. We changed our cardioplegia protocol from non-dN to dN administered in a single or infrequently dosed strategy in September 2013...
February 9, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28188951/the-influence-of-adrenergic-stimulation-on-sex-differences-in-left-ventricular-twist-mechanics
#5
Alexandra M Williams, Rob E Shave, William S Cheyne, Neil D Eves
BACKGROUND: Sex differences in LV mechanics exist at rest and during acute physiological stress. Differences in cardiac autonomic and adrenergic control may contribute to sex differences in LV mechanics and LV hemodynamics. Accordingly, this study aimed to investigate sex differences in LV mechanics with altered adrenergic stimulation achieved through post handgrip exercise ischemia (PEI) and β1 -adrenergic receptor (AR) blockade. METHODS AND RESULTS: 20 males (23 ± 5 yr) and 20 females (22 ± 3 yr) were specifically matched for LV length (males: 8...
February 11, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28183375/translating-clinical-trials-into-clinical-practice-a-survey-assessing-the-potential-impact-of-the-pediatric-heart-network-infant-single-ventricle-trial
#6
Victor Zak, Daphne T Hsu, Victoria L Pemberton, Jami C Levine, Andrew M Atz, James F Cnota, Chitra Ravishankar, Piers Barker, Linda M Lambert, Brian W McCrindle, Michele A Frommelt, Karen Altmann, Shan Chen, Richard V Williams
BACKGROUND: A few studies have evaluated the impact of clinical trial results on practice in paediatric cardiology. The Infant Single Ventricle (ISV) Trial results published in 2010 did not support routine use of the angiotensin-converting enzyme inhibitor enalapril in infants with single-ventricle physiology. We sought to assess the influence of these findings on clinical practice. METHODS: A web-based survey was distributed via e-mail to over 2000 paediatric cardiologists, intensivists, cardiothoracic surgeons, and cardiac advance practice nurses during three distribution periods...
February 10, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28137632/generation-6-hydroxyl-pamam-dendrimers-improve-cns-penetration-from-intravenous-administration-in-a-large-animal-brain-injury-model
#7
Fan Zhang, J Trent Magruder, Yi-An Lin, Todd C Crawford, Joshua C Grimm, Christopher M Sciortino, Mary Ann Wilson, Mary E Blue, Sujatha Kannan, Michael V Johnston, William A Baumgartner, Rangaramanujam M Kannan
Hypothermic circulatory arrest (HCA) provides neuroprotection during cardiac surgery but entails an ischemic period that can lead to excitotoxicity, neuroinflammation, and subsequent neurologic injury. Hydroxyl polyamidoamine (PAMAM) dendrimers target activated microglia and damaged neurons in the injured brain, and deliver therapeutics in small and large animal models. We investigated the effect of dendrimer size on brain uptake and explored the pharmacokinetics in a clinically-relevant canine model of HCA-induced brain injury...
January 27, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28129334/a-novel-positron-emission-tomography-pet-approach-to-monitor-cardiac-metabolic-pathway-remodeling-in-response-to-sunitinib-malate
#8
Alice C O'Farrell, Rhys Evans, Johanna M U Silvola, Ian S Miller, Emer Conroy, Suzanne Hector, Maurice Cary, David W Murray, Monika A Jarzabek, Ashwini Maratha, Marina Alamanou, Girish Mallya Udupi, Liam Shiels, Celine Pallaud, Antti Saraste, Heidi Liljenbäck, Matti Jauhiainen, Vesa Oikonen, Axel Ducret, Paul Cutler, Fionnuala M McAuliffe, Jacques A Rousseau, Roger Lecomte, Suzanne Gascon, Zoltan Arany, Bonnie Ky, Thomas Force, Juhani Knuuti, William M Gallagher, Anne Roivainen, Annette T Byrne
Sunitinib is a tyrosine kinase inhibitor approved for the treatment of multiple solid tumors. However, cardiotoxicity is of increasing concern, with a need to develop rational mechanism driven approaches for the early detection of cardiac dysfunction. We sought to interrogate changes in cardiac energy substrate usage during sunitinib treatment, hypothesising that these changes could represent a strategy for the early detection of cardiotoxicity. Balb/CJ mice or Sprague-Dawley rats were treated orally for 4 weeks with 40 or 20 mg/kg/day sunitinib...
2017: PloS One
https://www.readbyqxmd.com/read/28127121/interpretation-of-positive-troponin-results-among-patients-with-and-without-myocardial-infarction
#9
Kristen M Tecson, William Arnold, Tyler Barrett, Robert Birkhahn, Lori B Daniels, Christopher DeFilippi, Gary Headden, W Frank Peacock, Michael Reed, Adam J Singer, Jeffrey M Schussler, Stephen Smith, Martin P Than, Peter A McCullough
Measuring cardiac troponins is integral to diagnosing acute myocardial infarction (AMI); however, troponins may be elevated without AMI, and the use of multiple different assays confounds comparisons. We considered characteristics and serial troponin values in emergency department chest pain patients with and without AMI to interpret troponin excursions. We compared serial troponin in 124 AMI and non-AMI patients from the observational Performance of Triage Cardiac Markers in the Clinical Setting (PEARL) study who presented with chest pain and had at least one troponin value exceeding the 99th percentile of normal...
January 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28120739/management-of-complex-chd-at-the-national-cardiothoracic-center-of-excellence-university-of-nigeria-teaching-hospital-enugu-the-role-of-foreign-cardiac-missions-in-3-5-years
#10
Andrew I Nwafor, Josephat M Chinawa, Daberechi K Adiele, Ijeoma O Arodiwe, Ndubueze Ezemba, John C Eze, Ikenna Omeje, Onyiye A Arua, William Novick
BACKGROUND: CHD is defined as structural defect(s) in the heart and proximal blood vessels present at birth. The National Cardiothoracic Center of Excellence, University of Nigeria Teaching Hospital (UNTH), Enugu, through the aid of visiting Cardiac Missions has managed a significant number of patients within the last 3.5 years. Aim/Objective The objective of this study was to review surgical options and outcome of complex CHD among patients attending UNTH, Enugu, Enugu. Materials and Method During the period of 3...
January 25, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28119381/brain-emboli-after-left-ventricular-endocardial-ablation
#11
Isaac R Whitman, Rachel A Gladstone, Nitish Badhwar, Henry H Hsia, Byron Lee, S Andrew Josephson, Karl M Meisel, William P Dillon, Christopher Hess, Edward P Gerstenfeld, Gregory M Marcus
BACKGROUND: -Catheter ablation for ventricular tachycardia (VT) and premature ventricular complexes (PVCs) is common. Catheter ablation of atrial fibrillation is associated with a risk of cerebral emboli attributed to cardioversions and numerous ablation lesions in the low-flow left atrium, but cerebral embolic risk in ventricular ablation has not been evaluated. METHODS: -We enrolled 18 consecutive patients meeting study criteria scheduled for VT or PVC ablation over a 9-month period...
January 24, 2017: Circulation
https://www.readbyqxmd.com/read/28089599/impact-of-oral-chlorhexidine-on-bloodstream-infection-in-critically-ill-patients-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#12
REVIEW
Luciano Silvestri, William I Weir, Dario Gregori, Nia Taylor, Durk F Zandstra, Joris J M van Saene, Hendrick K F van Saene
OBJECTIVES: Oropharyngeal overgrowth of microorganisms in the critically ill is a risk factor for lower respiratory tract infection and subsequent invasion of the bloodstream. Oral chlorhexidine has been used to prevent pneumonia, but its effect on bloodstream infection never has been assessed in meta-analyses. The authors explored the effect of oral chlorhexidine on the incidence of bloodstream infection, the causative microorganism, and on all-cause mortality in critically ill patients...
November 2, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28081050/white-paper-of-the-society-of-computed-body-tomography-and-magnetic-resonance-on-dual-energy-ct-part-3-vascular-cardiac-pulmonary-and-musculoskeletal-applications
#13
Carlo N De Cecco, U Joseph Schoepf, Lynne Steinbach, Daniel T Boll, W Dennis Foley, Ravi K Kaza, David N Bolus, Desiree E Morgan, Dushyant V Sahani, William P Shuman, Marilyn J Siegel, Terri J Vrtiska, Benjamin M Yeh, Lincoln L Berland
This is the third of a series of 4 white papers that represent Expert Consensus Documents developed by the Society of Computed Body Tomography and Magnetic Resonance through its Task Force on dual-energy computed tomography. This paper, part 3, describes computed tomography angiography and thoracic, cardiac, vascular, and musculoskeletal clinical applications. At the end of the discussion of each application category (vascular, cardiac, pulmonary, and musculoskeletal), we present our consensus opinions on the current clinical utility of the application and opportunities for further research...
January 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28071824/heart-rate-variability-in-leucine-rich-repeat-kinase-2-associated-parkinson-s-disease
#14
Naomi P Visanji, Grace S Bhudhikanok, Tiago A Mestre, Taneera Ghate, Kaviraj Udupa, Amaal AlDakheel, Barbara S Connolly, Carmen Gasca-Salas, Drew S Kern, Jennifer Jain, Elizabeth J Slow, Achinoam Faust-Socher, Sam Kim, Ruksana Azhu Valappil, Farah Kausar, Ekaterina Rogaeva, J William Langston, Caroline M Tanner, Birgitt Schüle, Anthony E Lang, Samuel M Goldman, Connie Marras
BACKGROUND: Heart rate variability is reduced in idiopathic PD, indicating cardiac autonomic dysfunction likely resulting from peripheral autonomic synucleinopathy. Little is known about heart rate variability in leucine-rich repeat kinase 2-associated PD. OBJECTIVES: This study investigated heart rate variability in LRRK2-associated PD. METHODS: Resting electrocardiograms were obtained from 20 individuals with LRRK2-associated PD, 37 nonmanifesting carriers, 48 related noncarriers, 26 idiopathic PD patients, and 32 controls...
January 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28056866/case-report-whole-exome-sequencing-of-primary-cardiac-angiosarcoma-highlights-potential-for-targeted-therapies
#15
Leah Zhrebker, Irene Cherni, Lara M Gross, Margaret M Hinshelwood, Merrick Reese, Jessica Aldrich, Joseph M Guileyardo, William C Roberts, David Craig, Daniel D Von Hoff, Robert G Mennel, John D Carpten
BACKGROUND: Primary cardiac angiosarcomas are rare, but they are the most aggressive type of primary cardiac neoplasms. When patients do present, it is with advanced pulmonary and/or cardiac symptoms. Therefore, many times the correct diagnosis is not made at the time of initial presentation. These patients have metastatic disease and the vast majority of these patients die within a few months after diagnosis. Currently the treatment choices are limited and there are no targeted therapies available...
January 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28052152/types-of-myocardial-infarction-among-human-immunodeficiency-virus-infected-individuals-in-the-united-states
#16
Heidi M Crane, Pathmaja Paramsothy, Daniel R Drozd, Robin M Nance, J A Chris Delaney, Susan R Heckbert, Matthew J Budoff, Greer A Burkholder, James H Willig, Michael J Mugavero, William C Mathews, Paul K Crane, Richard D Moore, Joseph J Eron, Sonia Napravnik, Peter W Hunt, Elvin Geng, Priscilla Hsue, Carla Rodriguez, Inga Peter, Greg S Barnes, Justin McReynolds, William B Lober, Kristina Crothers, Mathew Feinstein, Carl Grunfeld, Michael S Saag, Mari M Kitahata
Importance: The Second Universal Definition of Myocardial Infarction (MI) divides MIs into different types. Type 1 MIs result spontaneously from instability of atherosclerotic plaque, whereas type 2 MIs occur in the setting of a mismatch between oxygen demand and supply, as with severe hypotension. Type 2 MIs are uncommon in the general population, but their frequency in human immunodeficiency virus (HIV)-infected individuals is unknown. Objectives: To characterize MIs, including type; identify causes of type 2 MIs; and compare demographic and clinical characteristics among HIV-infected individuals with type 1 vs type 2 MIs...
January 4, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28046063/three-dimensional-high-frequency-ultrasonography-for-early-detection-and-characterization-of-embryo-implantation-site-development-in-the-mouse
#17
Mary C Peavey, Corey L Reynolds, Maria M Szwarc, William E Gibbons, Cecilia T Valdes, Francesco J DeMayo, John P Lydon
Ultrasonography is a powerful tool to non-invasively monitor in real time the development of the human fetus in utero. Although genetically engineered mice have served as valuable in vivo models to study both embryo implantation and pregnancy progression, such studies usually require sacrifice of parous mice for subsequent phenotypic analysis. To address this issue, we used three-dimensional (3-D) reconstruction in silico of high-frequency ultrasound (HFUS) imaging data for early detection and characterization of murine embryo implantation sites and their development in utero...
2017: PloS One
https://www.readbyqxmd.com/read/28039604/socioeconomic-and-racial-disparities-a-case-control-study-of-patients-receiving-transcatheter-aortic-valve-replacement-for-severe-aortic-stenosis
#18
Anna Sleder, Shiloh Tackett, Matthew Cerasale, Chetan Mittal, Iyad Isseh, Ryhm Radjef, Andrew Taylor, Rashad Farha, Oleksandra Lupak, Dana Larkin, Lois Lamerato, George Divine, Kimberlydawn Wisdom, Kimberly Baker-Genaw, William O'Neill
BACKGROUND: We sought to quantify socioeconomic disparities in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) at an urban, tertiary referral center. METHODS: This retrospective case-control study identified 67 patients with severe AS (aortic valve [AV] area ≤1 cm(2) or AV area index ≤0.60 cm(2)/m(2) or AV velocity ≥40 mmHg) who underwent TAVR from November 5, 2013 to June 10, 2014. Study subjects were matched to controls with severe AS without TAVR in a 4:1 age-frequency match...
December 30, 2016: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28025309/safety-and-efficacy-of-prophylactic-negative-pressure-wound-therapy-following-open-saphenous-vein-harvest-in-cardiac-surgery-a-feasibility-study
#19
Arthur J Lee, Christina E Sheppard, William D T Kent, Holly Mewhort, Khokan C Sikdar, Paul W M Fedak
OBJECTIVES: Surgical site complications following great saphenous vein (GSV) harvest presents a significant risk of morbidity. Negative pressure wound therapy (NPWT) has shown promise in the treatment and prophylaxis of open wounds and surgical incisions but has not been studied following GSV harvest. We performed a feasibility study examining the use of NPWT following GSV harvest for coronary bypass surgery. METHODS: Sixty-four patients were recruited in this single-centre, single-blind, randomized controlled trial...
December 26, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28025189/cardiopoietic-cell-therapy-for-advanced-ischemic-heart-failure-results-at-39-weeks-of-the-prospective-randomized-double-blind-sham-controlled-chart-1-clinical-trial
#20
Jozef Bartunek, Andre Terzic, Beth A Davison, Gerasimos S Filippatos, Slavica Radovanovic, Branko Beleslin, Bela Merkely, Piotr Musialek, Wojciech Wojakowski, Peter Andreka, Ivan G Horvath, Amos Katz, Dariouch Dolatabadi, Badih El Nakadi, Aleksandra Arandjelovic, Istvan Edes, Petar M Seferovic, Slobodan Obradovic, Marc Vanderheyden, Nikola Jagic, Ivo Petrov, Shaul Atar, Majdi Halabi, Valeri L Gelev, Michael K Shochat, Jaroslaw D Kasprzak, Ricardo Sanz-Ruiz, Guy R Heyndrickx, Noémi Nyolczas, Victor Legrand, Antoine Guédès, Alex Heyse, Tiziano Moccetti, Francisco Fernandez-Aviles, Pilar Jimenez-Quevedo, Antoni Bayes-Genis, Jose Maria Hernandez-Garcia, Flavio Ribichini, Marcin Gruchala, Scott A Waldman, John R Teerlink, Bernard J Gersh, Thomas J Povsic, Timothy D Henry, Marco Metra, Roger J Hajjar, Michal Tendera, Atta Behfar, Bertrand Alexandre, Aymeric Seron, Wendy Gattis Stough, Warren Sherman, Gad Cotter, William Wijns
AIMS: Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort. METHODS AND RESULTS: This multinational, randomized, double-blind, sham-controlled study was conducted in 39 hospitals. Patients with symptomatic ischemic heart failure on guideline-directed therapy (n = 484) were screened; n = 348 underwent bone marrow harvest and mesenchymal stem cell expansion...
December 23, 2016: European Heart Journal
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