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https://www.readbyqxmd.com/read/28630913/an-innovative-biologic-system-for-photon-powered-myocardium-in-the-ischemic-heart
#1
Jeffrey E Cohen, Andrew B Goldstone, Michael J Paulsen, Yasuhiro Shudo, Amanda N Steele, Bryan B Edwards, Jay B Patel, John W MacArthur, Michael S Hopkins, Casey E Burnett, Kevin J Jaatinen, Akshara D Thakore, Justin M Farry, Vi N Truong, Alexandra T Bourdillon, Lyndsay M Stapleton, Anahita Eskandari, Alexander S Fairman, William Hiesinger, Tatiana V Esipova, William L Patrick, Keven Ji, Judith A Shizuru, Y Joseph Woo
Coronary artery disease is one of the most common causes of death and disability, afflicting more than 15 million Americans. Although pharmacological advances and revascularization techniques have decreased mortality, many survivors will eventually succumb to heart failure secondary to the residual microvascular perfusion deficit that remains after revascularization. We present a novel system that rescues the myocardium from acute ischemia, using photosynthesis through intramyocardial delivery of the cyanobacterium Synechococcus elongatus...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28629419/effect-of-beta-blockers-on-exacerbation-rate-and-lung-function-in-chronic-obstructive-pulmonary-disease-copd
#2
Sean Duffy, Robert Marron, Helen Voelker, Richard Albert, John Connett, William Bailey, Richard Casaburi, J Allen Cooper, Jeffrey L Curtis, Mark Dransfield, MeiLan K Han, Barry Make, Nathaniel Marchetti, Fernando Martinez, Stephen Lazarus, Dennis Niewoehner, Paul D Scanlon, Frank Sciurba, Steven Scharf, Robert M Reed, George Washko, Prescott Woodruff, Charlene McEvoy, Shawn Aaron, Don Sin, Gerard J Criner
BACKGROUND: Beta-blockers are commonly prescribed for patients with cardiovascular disease. Providers have been wary of treating chronic obstructive pulmonary disease (COPD) patients with beta-blockers due to concern for bronchospasm, but retrospective studies have shown that cardio-selective beta-blockers are safe in COPD and possibly beneficial. However, these benefits may reflect symptom improvements due to the cardiac effects of the medication. The purpose of this study is to evaluate associations between beta-blocker use and both exacerbation rates and longitudinal measures of lung function in two well-characterized COPD cohorts...
June 19, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28625374/change-the-management-of-patients-with-heart-failure-rationale-and-design-of-the-champ-hf-registry
#3
Adam D DeVore, Laine Thomas, Nancy M Albert, Javed Butler, Adrian F Hernandez, J Herbert Patterson, John A Spertus, Fredonia B Williams, Stuart J Turner, Wing W Chan, Carol I Duffy, Kevin McCague, Xiaojuan Mi, Gregg C Fonarow
Heart failure (HF) with reduced ejection fraction (HFrEF) is a common and costly condition that diminishes patients' health status and confers a poor prognosis. Despite the availability of multiple guideline-recommended pharmacologic and cardiac device therapies for patients with chronic HFrEF, outcomes remain suboptimal. Currently, there is limited insight into the rationale underlying clinical decisions by health care providers and patient factors that guide the use and intensity of outpatient HF treatments...
July 2017: American Heart Journal
https://www.readbyqxmd.com/read/28624641/text-mining-applied-to-electronic-cardiovascular-procedure-reports-to-identify-patients-with-trileaflet-aortic-stenosis-and-coronary-artery-disease
#4
Aeron M Small, Daniel H Kiss, Yevgeny Zlatsin, David L Birtwell, Heather Williams, Marie A Guerraty, Yuchi Han, Saif Anwaruddin, John H Holmes, Julio A Chirinos, Robert L Wilensky, Jay Giri, Daniel J Rader
BACKGROUND: Interrogation of the electronic health record (EHR) using billing codes as a surrogate for diagnoses of interest has been widely used for clinical research. However, the accuracy of this methodology is variable, as it reflects billing codes rather than severity of disease, and depends on the disease and the accuracy of the coding practitioner. Systematic application of text mining to the EHR has had variable success for the detection of cardiovascular phenotypes. We hypothesize that the application of text mining algorithms to cardiovascular procedure reports may be a superior method to identify patients with cardiovascular conditions of interest...
June 14, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28621257/oral-transmucosal-detomidine-gel-in-new-zealand-white-rabbits-oryctolagus-cuniculus
#5
Morika D Williams, C Tyler Long, Jessica R Durrant, Gabriel P McKeon, Heather R Shive, Emily H Griffith, Kristen M Messenger, Richard E Fish
Handling and restraining rabbits for routine procedures may be impossible without prior sedation, result in unnecessarystress or injury to the rabbit or handler, and increase experimental variability. Parenteral administration of sedatives can cause stress also, as well as localized pain and tissue damage, especially in fractious animals. Detomidine hydrochloride, an α2-adrenergic receptor agonist, is commercially available in an oral transmucosal (OTM) gel formulation that is FDA-approved for sedation and restraint in horses...
June 15, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28614792/cd4-t-lymphocytes-produce-adiponectin-in-response-to-transplants
#6
Sreedevi Danturti, Karen S Keslar, Leah R Steinhoff, Ran Fan, Nina Dvorina, Anna Valujskikh, Robert L Fairchild, William M Baldwin
Adiponectin is a pleiotropic cytokine with diverse immunomodulatory effects on macrophages and lymphocytes. In the current paradigm, lymphocytes and macrophages respond to adiponectin that is produced by adipocytes and other parenchymal cells. Using a model of chronic arterial inflammation in cardiac transplants, we found that T cells derived from the recipient migrate to the heart and produce adiponectin locally. The evidence that T cells produce significant amounts of adiponectin is based on 3 experimental approaches...
June 15, 2017: JCI Insight
https://www.readbyqxmd.com/read/28614129/perioperative-low-arterial-oxygenation-is-associated-with-increased-stroke-risk-in-cardiac-surgery
#7
Alexandra M Dunham, Maura A Grega, Charles H Brown, Guy M McKhann, William A Baumgartner, Rebecca F Gottesman
BACKGROUND: Both patient characteristics and intraoperative factors have been associated with a higher risk of stroke after cardiac surgery. We hypothesized that poor systemic oxygenation in the perioperative period is associated with increased risk of stroke following cardiopulmonary bypass. METHODS: In this study of 251 adult patients who underwent cardiopulmonary bypass procedures at a single center from 2003 to 2006, cases (patients with a postoperative stroke at least 24 hours after surgery) were matched 1:2 to controls without stroke...
July 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28608907/organs-on-chips-with-combined-multi-electrode-array-and-transepithelial-electrical-resistance-measurement-capabilities
#8
Ben M Maoz, Anna Herland, Olivier Y F Henry, William D Leineweber, Moran Yadid, John Doyle, Robert Mannix, Ville J Kujala, Edward A FitzGerald, Kevin Kit Parker, Donald E Ingber
Here we demonstrate that microfluidic cell culture devices, known as Organs-on-a-Chips can be fabricated with multifunctional, real-time, sensing capabilities by integrating both multi-electrode arrays (MEAs) and electrodes for transepithelial electrical resistance (TEER) measurements into the chips during their fabrication. To prove proof-of-concept, simultaneous measurements of cellular electrical activity and tissue barrier function were carried out in a dual channel, endothelialized, heart-on-a-chip device containing human cardiomyocytes and a channel-separating porous membrane covered with a primary human endothelial cell monolayer...
June 13, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28599999/-tell-me-exactly-what-s-happened-when-linguistic-choices-affect-the-efficiency-of-emergency-calls-for-cardiac-arrest
#9
Marine Riou, Stephen Ball, Teresa A Williams, Austin Whiteside, Kay L O'Halloran, Janet Bray, Gavin D Perkins, Karen Smith, Peter Cameron, Daniel M Fatovich, Madoka Inoue, Paul Bailey, Deon Brink, Judith Finn
BACKGROUND: Clear and efficient communication between emergency caller and call-taker is crucial to timely ambulance dispatch. We aimed to explore the impact of linguistic variation in the delivery of the prompt "okay, tell me exactly what happened" on the way callers describe the emergency in the Medical Priority Dispatch System(®). METHODS: We analysed 188 emergency calls for cases of paramedic-confirmed out-of-hospital cardiac arrest. We investigated the linguistic features of the prompt "okay, tell me exactly what happened" in relation to the format (report vs...
June 12, 2017: Resuscitation
https://www.readbyqxmd.com/read/28599828/a-doppler-echocardiographic-study-of-the-myocardial-inotropic-response-to-peak-semisupine-exercise-in-healthy-children-development-of-a-simplified-index-of%C3%A2-myocardial%C3%A2-reserve
#10
Anita T Cote, D Kathryn Duff, Carolina A Escudero, Astrid M De Souza, Lindsey D Williams, Raman Gill, M Terri Zadorsky, Kevin C Harris, James E Potts, George G S Sandor
BACKGROUND: Stress echocardiography has been advocated for the detection of abnormal myocardial function and unmasking diminished myocardial reserve in pediatric patients. The aim of this study was to create a simplified index of myocardial reserve, derived from the myocardial inotropic response to peak semisupine exercise in healthy children, and illustrate its applicability in a sample of pediatric oncology patients. METHODS: In this prospective analysis, children (7-18 years of age) with normal cardiac structure and function performed semisupine stress echocardiography to volitional fatigue...
June 6, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28598945/long-term-outcomes-of-pediatric-cardiac-patients-supported-by-extracorporeal-membrane-oxygenation
#11
Matthew D Elias, Barbara-Jo Achuff, Richard F Ittenbach, Chitra Ravishankar, Thomas L Spray, Stephanie Fuller, Lisa M Montenegro, J William Gaynor, Matthew J O'Connor
OBJECTIVE: Extracorporeal membrane oxygenation is an important form of short-term mechanical support in children with cardiac disease, but information on long-term outcomes and quality of life is limited. The primary objective of this study was to determine the long-term outcomes of children previously supported by extracorporeal membrane oxygenation for cardiac etiologies. DESIGN: A retrospective analysis was performed on patients with cardiac disease managed with extracorporeal membrane oxygenation between January 1, 1995, and December 31, 2012, at the Children's Hospital of Philadelphia...
June 8, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28583371/bacterial-infections-after-pediatric-heart-transplantation-epidemiology-risk-factors-and-outcomes
#12
Christina A Rostad, Karla Wehrheim, James K Kirklin, David Naftel, Elizabeth Pruitt, Timothy M Hoffman, Thomas L'Ecuyer, Katie Berkowitz, William T Mahle, Janet N Scheel
BACKGROUND: Bacterial infections represent a major cause of morbidity and mortality in heart transplant recipients. However, data describing the epidemiology and outcomes of these infections in children are limited. METHODS: We analyzed the Pediatric Heart Transplant Study database of patients transplanted between 1993 and 2014 to determine the etiologies, risk factors and outcomes of children with bacterial infections post-heart transplantation. RESULTS: Of 4,458 primary transplants in the database, there were 4,815 infections that required hospitalization or intravenous therapy, 2,047 (42...
May 11, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28575235/remote-management-of-heart-failure-using-implantable-electronic-devices
#13
John M Morgan, Sue Kitt, Jas Gill, Janet M McComb, Ghulam Andre Ng, James Raftery, Paul Roderick, Alison Seed, Simon G Williams, Klaus K Witte, David Jay Wright, Scott Harris, Martin R Cowie
Aims: Remote management of heart failure using implantable electronic devices (REM-HF) aimed to assess the clinical and cost-effectiveness of remote monitoring (RM) of heart failure in patients with cardiac implanted electronic devices (CIEDs). Methods and results: Between 29 September 2011 and 31 March 2014, we randomly assigned 1650 patients with heart failure and a CIED to active RM or usual care (UC). The active RM pathway included formalized remote follow-up protocols, and UC was standard practice in nine recruiting centres in England...
May 27, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28574105/development-of-a-prolonged-warm-ex-vivo-perfusion-model-for-kidneys-donated-after-cardiac-death
#14
Daniel Urcuyo, Matthew F Blum, Qiang Liu, Ahmed Nassar, Laura D Buccini, Teresa Diago Uso, Emilio D Poggio, William M Baldwin Iii, David A Goldfarb, Cristiano Quintini
PURPOSE: Ex vivo perfusion of marginal kidney grafts offers the chance to expand the donor pool, but there is no current clinical standard for the prolonged warm perfusion of renal grafts. This exploratory pilot study seeks to identify a stable ex vivo kidney perfusion model that can support low intravascular resistance and preserve histologic architecture in a porcine donation after cardiac death (DCD) model. METHODS: 15 kidneys were preserved in 1 of 3 settings: normothermic whole blood (NT-WB), normothermic Steen Solution™ (XVIVO Perfusion) with whole blood (NT-Steen/WB), or subnormothermic Steen Solution™ at 21°C (SNT-Steen)...
May 24, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28571639/longitudinal-outcomes-of-patients%C3%A2-with%C3%A2-single-ventricle-after%C3%A2-the%C3%A2-fontan%C3%A2-procedure
#15
Andrew M Atz, Victor Zak, Lynn Mahony, Karen Uzark, Nicholas D'agincourt, David J Goldberg, Richard V Williams, Roger E Breitbart, Steven D Colan, Kristin M Burns, Renee Margossian, Heather T Henderson, Rosalind Korsin, Bradley S Marino, Kaitlyn Daniels, Brian W McCrindle
BACKGROUND: Multicenter longitudinal objective data for survival into adulthood of patients who have undergone Fontan procedures are lacking. OBJECTIVES: This study sought to describe transplant-free survival and explore relationships between laboratory measures of ventricular performance and functional status over time. METHODS: Exercise testing, echocardiography, B-type natriuretic peptide, functional health assessment, and medical history abstraction were repeated 9...
June 6, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28567354/aortic-flow-conditions-predict-ejection-efficiency-in-the-nhlbi-sponsored-women-s-ischemia-syndrome-evaluation-wise
#16
Mark Doyle, Gerald M Pohost, C Noel Bairey Merz, Victor Farah, Leslee J Shaw, George Sopko, William J Rogers, Barry L Sharaf, Carl J Pepine, Diane V Thompson, Geetha Rayarao, Lindsey Tauxe, Sheryl F Kelsey, Robert W W Biederman
BACKGROUND: The Windkessel model of the cardiovascular system, both in its original wind-chamber and flow-pipe form, and in its electrical circuit analog has been used for over a century to modeled left ventricular ejection conditions. Using parameters obtained from aortic flow we formed a Flow Index that is proportional to the impedance of such a "circuit". We show that the impedance varies with ejection fraction (EF) in a manner characteristic of a resonant circuit with multiple resonance points, with each resonance point centrally located in a small range of EF values, i...
June 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28562133/dietary-nitrate-does-not-modify-blood-pressure-and-cardiac-output-at-rest-and-during-exercise-in-older-adults-a-randomised-cross-over-study
#17
C Oggioni, D G Jakovljevic, M Klonizakis, A W Ashor, A Ruddock, M Ranchordas, E Williams, M Siervo
Dietary nitrate (NO3(-)) supplementation has been associated with improved vascular and metabolic health. We conducted a double-blind, cross-over, placebo-controlled RCT to investigate the effects of 7-d consumption of beetroot juice compared with placebo on (1) blood pressure (BP) measured in resting conditions and during exercise, (2) cardiac and peripheral vascular function and (3) biomarkers of inflammation, oxidative stress and endothelial integrity. Twenty non-smoking healthy participants aged 60-75 years and BMI 20...
May 31, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28552749/the-tpeak-tend-interval-as-an-electrocardiographic-risk-marker-of-arrhythmic-and-mortality-outcomes-a-systematic-review-and-meta-analysis
#18
Gary Tse, Mengqi Gong, Wing Tak Wong, Stamatis Georgopoulos, Konstantinos P Letsas, Vassilios S Vassiliou, Yat Sun Chan, Bryan P Yan, Sunny Hei Wong, William K K Wu, Ana Ciobanu, Guangping Li, Jayaprakash Shenthar, Ardan M Saguner, Sadeq Ali-Hasan-Al-Saegh, Aishwarya Bhardwaj, Abhishek C Sawant, Paula Whittaker, Yunlong Xia, Gan-Xin Yan, Tong Liu
BACKGROUND: The Tpeak - Tend interval (the interval from the peak to the end of the T wave), an electrocardiographic marker reflecting transmural dispersion of repolarization, has been used to predict ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death in different clinical settings. OBJECTIVE: This systematic review and meta-analysis evaluated the significance of the Tpeak - Tend interval in predicting arrhythmic and/or mortality end points. METHODS: PubMed, Embase, Cochrane Library, and CINAHL Plus databases were searched through November 30, 2016...
May 26, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28542926/effect-of-spironolactone-on-exercise-tolerance-and-arterial-function-in-older-adults-with-heart-failure-with-preserved-ejection-fraction
#19
Bharathi Upadhya, William G Hundley, Peter H Brubaker, Timothy M Morgan, Kathryn P Stewart, Dalane W Kitzman
OBJECTIVES: To evaluate the effects of an aldosterone antagonist on exercise intolerance in older adults with heart failure and preserved ejection fraction (HFpEF). DESIGN: Randomized, placebo-controlled, double-blind trial. SETTING: Academic medical center, Winston-Salem, North Carolina. PARTICIPANTS: Older adults (N = 80, aged 71 ± 1; 80% female) with stable compensated HFpEF and controlled blood pressure (BP)...
May 19, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28540527/alignment-of-inducible-vascular-progenitor-cells-on-a-micro-bundle-scaffold-improves-cardiac-repair-following-myocardial-infarction
#20
Anurag Jamaiyar, Weiguo Wan, Vahagn Ohanyan, Molly Enrick, Danielle Janota, Devan Cumpston, Hokyung Song, Kelly Stevanov, Christopher L Kolz, Tatev Hakobyan, Feng Dong, Bi-Min Zhang Newby, William M Chilian, Liya Yin
Ischemic heart disease is still the leading cause of death even with the advancement of pharmaceutical therapies and surgical procedures. Early vascularization in the ischemic heart is critical for a better outcome. Although stem cell therapy has great potential for cardiovascular regeneration, the ideal cell type and delivery method of cells have not been resolved. We tested a new approach of stem cell therapy by delivery of induced vascular progenitor cells (iVPCs) grown on polymer micro-bundle scaffolds in a rat model of myocardial infarction...
July 2017: Basic Research in Cardiology
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