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https://www.readbyqxmd.com/read/29764606/sex-and-family-history-of-cardiovascular-disease-influence-heart-rate-variability-during-stress-among-healthy-adults
#1
Charles F Emery, Catherine M Stoney, Julian F Thayer, DeWayne Williams, Andrew Bodine
OBJECTIVE: Studies of sex differences in heart rate variability (HRV) typically have not accounted for the influence of family history (FH) of cardiovascular disease (CVD). This study evaluated sex differences in HRV response to speech stress among men and women (age range 30-49 years) with and without a documented FH of CVD. METHODS: Participants were 77 adults (mean age = 39.8 ± 6.2 years; range: 30-49 years; 52% female) with positive FH (FH+, n = 32) and negative FH (FH-, n = 45) of CVD, verified with relatives of participants...
July 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29760852/altered-mental-status-current-evidence-based-recommendations-for-prehospital-care
#2
REVIEW
Ashley Sanello, Marianne Gausche-Hill, William Mulkerin, Karl A Sporer, John F Brown, Kristi L Koenig, Eric M Rudnick, Angelo A Salvucci, Gregory H Gilbert
Introduction: In the United States emergency medical services (EMS) protocols vary widely across jurisdictions. We sought to develop evidence-based recommendations for the prehospital evaluation and treatment of a patient with an acute change in mental status and to compare these recommendations against the current protocols used by the 33 EMS agencies in the State of California. Methods: We performed a literature review of the current evidence in the prehospital treatment of a patient with altered mental status (AMS) and augmented this review with guidelines from various national and international societies to create our evidence-based recommendations...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29760219/detectable-high-sensitivity-cardiac-troponin-within-the-population-reference-interval-conveys-high-5-year-cardiovascular-risk-an-observational-study
#3
Martin P Than, Sally J Aldous, Richard W Troughton, Christopher J Pemberton, A Mark Richards, Christopher M A Frampton, Christopher M Florkowski, Peter M George, Samantha Bailey, Joanna M Young, Louise Cullen, Jaimi H Greenslade, William A Parsonage, Brendan M Everett, W Frank Peacock, Allan S Jaffe, John W Pickering
BACKGROUND: Increased cardiac troponin I or T detected by high-sensitivity assays (hs-cTnI or hs-cTnT) confers an increased risk of adverse prognosis. We determined whether patients presenting with putatively normal, detectable cTn concentrations [> limit of detection and < upper reference limit (URL)] have increased risk of major adverse cardiovascular events (MACE) or all-cause mortality. METHODS: A prospective 5-year follow-up of patients recruited in the emergency department with possible acute coronary syndrome (ACS) and cTn concentrations measured with hs-cTnI (Abbott) and hs-cTnT (Roche) assays...
May 14, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29754671/rationale-and-design-for-the-vascular-outcomes-study-of-asa-along-with-rivaroxaban-in-endovascular-or-surgical-limb-revascularization-for-peripheral-artery-disease-voyager-pad
#4
Warren H Capell, Marc P Bonaca, Mark R Nehler, Edmond Chen, John M Kittelson, Sonia S Anand, Scott D Berkowitz, Eike Sebastian Debus, Fabrizio Fanelli, Lloyd Haskell, Manesh R Patel, Rupert Bauersachs, William R Hiatt
BACKGROUND: Patients with peripheral artery disease (PAD) undergoing a lower-extremity revascularization are at heightened risk for ischemic cardiac and limb events. Although intensification of antithrombotic therapy after revascularization has demonstrated benefit in coronary disease populations, this approach has not been well studied or shown consistent benefit in PAD. Recent trial evidence demonstrated that a treatment strategy of rivaroxaban added to background antiplatelet therapy reduced ischemic risk in patients following recent acute coronary syndromes, as well as in patients with stable atherosclerotic vascular disease...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29752399/common-coding-variants-in-scn10a-are-associated-with-the-nav1-8-late-current-and-cardiac-conduction
#5
Vincenzo Macri, Jennifer A Brody, Dan E Arking, William J Hucker, Xiaoyan Yin, Honghuang Lin, Robert W Mills, Moritz F Sinner, Steven A Lubitz, Ching-Ti Liu, Alanna C Morrison, Alvaro Alonso, Ning Li, Vadim V Fedorov, Paul M Janssen, Joshua C Bis, Susan R Heckbert, Elena V Dolmatova, Thomas Lumley, Colleen M Sitlani, L Adrienne Cupples, Sara L Pulit, Christopher Newton-Cheh, John Barnard, Jonathan D Smith, David R Van Wagoner, Mina K Chung, Gus J Vlahakes, Christopher J O'Donnell, Jerome I Rotter, Kenneth B Margulies, Michael P Morley, Thomas P Cappola, Emelia J Benjamin, Donna Muzny, Richard A Gibbs, Rebecca D Jackson, Jared W Magnani, Caroline N Herndon, Stephen S Rich, Bruce M Psaty, David J Milan, Eric Boerwinkle, Peter J Mohler, Nona Sotoodehnia, Patrick T Ellinor
BACKGROUND: Genetic variants at the SCN5A / SCN10A locus are strongly associated with electrocardiographic PR and QRS intervals. While SCN5A is the canonical cardiac sodium channel gene, the role of SCN10A in cardiac conduction is less well characterized. METHODS: We sequenced the SCN10A locus in 3699 European-ancestry individuals to identify variants associated with cardiac conduction, and replicated our findings in 21,000 individuals of European ancestry. We examined association with expression in human atrial tissue...
May 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29750365/effect-of-coronary-revascularization-on-long-term-clinical-outcomes-in-patients-with-ischemic-cardiomyopathy-and-recurrent-ventricular-arrhythmia
#6
Ihab Elsokkari, Ratika Parkash, Chris J Gray, Martin J Gardner, Amir M AbdelWahab, Steve Doucette, Anthony S Tang, George A Wells, William G Stevenson, John L Sapp
BACKGROUND: Patients with ventricular tachycardia (VT) post myocardial infarction (MI) are a higher risk group with significant morbidity and mortality. We examined the impact of prior coronary revascularization on clinical outcomes in patients with ischemic cardiomyopathy (ICM) and VT. METHODS: The VANISH trial randomized 259 patients with prior MI and antiarrhythmic drug-refractory VT to receive escalated medical therapy or catheter ablation. Clinical outcomes were compared according to whether patients have undergone prior revascularization procedures...
May 11, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29748316/common-and-rare-coding-genetic-variation-underlying-the-electrocardiographic-pr-interval
#7
Honghuang Lin, Jessica van Setten, Albert V Smith, Nathan A Bihlmeyer, Helen R Warren, Jennifer A Brody, Farid Radmanesh, Leanne Hall, Niels Grarup, Martina Müller-Nurasyid, Thibaud Boutin, Niek Verweij, Henry J Lin, Ruifang Li-Gao, Marten E van den Berg, Jonathan Marten, Stefan Weiss, Bram P Prins, Jeffrey Haessler, Leo-Pekka Lyytikäinen, Hao Mei, Tamara B Harris, Lenore J Launer, Man Li, Alvaro Alonso, Elsayed Z Soliman, John M Connell, Paul L Huang, Lu-Chen Weng, Heather S Jameson, William Hucker, Alan Hanley, Nathan R Tucker, Yii-Der Ida Chen, Joshua C Bis, Kenneth M Rice, Colleen M Sitlani, Jan A Kors, Zhijun Xie, Chengping Wen, Jared W Magnani, Christopher P Nelson, Jørgen K Kanters, Moritz F Sinner, Konstantin Strauch, Annette Peters, Melanie Waldenberger, Thomas Meitinger, Jette Bork-Jensen, Oluf Pedersen, Allan Linneberg, Igor Rudan, Rudolf A de Boer, Peter van der Meer, Jie Yao, Xiuqing Guo, Kent D Taylor, Nona Sotoodehnia, Jerome I Rotter, Dennis O Mook-Kanamori, Stella Trompet, Fernando Rivadeneira, André Uitterlinden, Mark Eijgelsheim, Sandosh Padmanabhan, Blair H Smith, Henry Völzke, Stephan B Felix, Georg Homuth, Uwe Völker, Massimo Mangino, Timothy D Spector, Michiel L Bots, Marco Perez, Mika Kähönen, Olli T Raitakari, Vilmundur Gudnason, Dan E Arking, Patricia B Munroe, Bruce M Psaty, Cornelia M van Duijn, Emelia J Benjamin, Jonathan Rosand, Nilesh J Samani, Torben Hansen, Stefan Kääb, Ozren Polasek, Pim van der Harst, Susan R Heckbert, J Wouter Jukema, Bruno H Stricker, Caroline Hayward, Marcus Dörr, Yalda Jamshidi, Folkert W Asselbergs, Charles Kooperberg, Terho Lehtimäki, James G Wilson, Patrick T Ellinor, Steven A Lubitz, Aaron Isaacs
BACKGROUND: Electrical conduction from the cardiac sinoatrial node to the ventricles is critical for normal heart function. Genome-wide association studies have identified more than a dozen common genetic loci that are associated with PR interval. However, it is unclear whether rare and low-frequency variants also contribute to PR interval heritability. METHODS: We performed large-scale meta-analyses of the PR interval that included 83 367 participants of European ancestry and 9436 of African ancestry...
May 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29735525/orthostatic-hypotension-and-risk-of-clinical-and-subclinical-cardiovascular-disease-in-middle-aged-adults
#8
Stephen P Juraschek, Natalie Daya, Lawrence J Appel, Edgar R Miller, John William McEvoy, Kunihiro Matsushita, Christie M Ballantyne, Elizabeth Selvin
BACKGROUND: Although orthostatic hypotension (OH) is a well-recognized manifestation of neuropathy and hypovolemia, its contribution to cardiovascular disease (CVD) risk is controversial. METHODS AND RESULTS: Participants with OH, defined as a decrease in blood pressure (systolic ≥20 mm Hg or diastolic ≥10 mm Hg) from the supine to standing position, were identified during the first visit of the ARIC (Atherosclerosis Risk in Communities) Study (1987-1989) within 2 minutes of standing...
May 7, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29729284/direct-transport-to-a-pci-capable-hospital-is-associated-with-improved-survival-after-adult-out-of-hospital-cardiac-arrest-of-medical-aetiology
#9
Nicole McKenzie, Teresa A Williams, Kwok M Ho, Madoka Inoue, Paul Bailey, Antonio Celenza, Daniel Fatovich, Ian Jenkins, Judith Finn
AIM: To compare survival outcomes of adults with out-of-hospital cardiac arrest (OHCA) of medical aetiology directly transported to a percutaneous-coronary-intervention capable (PCI-capable) hospital (direct transport) with patients transferred to a PCI-capable hospital via another hospital without PCI services available (indirect transport) by emergency medical services (EMS). METHODS: This retrospective cohort study used the St John Ambulance Western Australia OHCA Database and medical chart review...
May 2, 2018: Resuscitation
https://www.readbyqxmd.com/read/29727214/hemodynamic-effects-of-incremental-lung-hyperinflation
#10
William Spencer Cheyne, Jinelle C M Gelinas, Neil Derek Eves
Dynamic hyperinflation (DH) is common in COPD and is associated with dyspnea and exercise intolerance. DH also has adverse cardiac effects, though the magnitude of DH and the mechanisms responsible for the hemodynamic impairment remain unclear. We hypothesized that incrementally increasing DH would systematically reduce left-ventricular (LV) end diastolic volume (LVEDV) and stroke volume (LVSV) due to direct ventricular interaction (DVI). Twenty-three healthy subjects (22{plus minus}2yrs) were exposed to varying degrees of expiratory loading to induce DH such that inspiratory capacity (IC) was decreased by 25, 50, 75 and 100%, (100% DH = IC of resting tidal volume plus inspiratory reserve volume ≈0...
May 4, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29716905/mobilization-therapy-in-the-pediatric-intensive-care-unit-a-multidisciplinary-quality-improvement-initiative
#11
Blair R L Colwell, Cydni N Williams, Serena P Kelly, Laura M Ibsen
BACKGROUND: Mobilization is safe and associated with improved outcomes in critically ill adults, but little is known about mobilization of critically ill children. OBJECTIVE: To implement a standardized mobilization therapy protocol in a pediatric intensive care unit and improve mobilization of patients. METHODS: A goal-directed mobilization protocol was instituted as a quality improvement project in a 20-bed cardiac and medical-surgical pediatric intensive care unit within an academic tertiary care center...
May 2018: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/29709534/measurement-of-microvascular-function-in-patients-presenting-with-thrombolysis-for-st-elevation-myocardial-infarction-and-pci-for-non-st-elevation-myocardial-infarction
#12
Sonny Palmer, Jamie Layland, Heath Adams, Srikkumar Ashokkumar, Paul D Williams, Christopher Judkins, Andre La Gerche, Andrew T Burns, Robert J Whitbourn, Andrew I MacIsaac, Andrew M Wilson
BACKGROUND: In this prospective study, we compared the invasive measures of microvascular function in two subsets: patients with pharmacoinvasive thrombolysis for STEMI, and patients undergoing percutaneous coronary intervention (PCI) for NSTEMI. METHODS: The study consisted of 17 patients with STEMI referred for cardiac catheterisation post thrombolysis, and 20 patients with NSTEMI. Coronary physiological indexes were measured in each patient before and after PCI...
April 12, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29706235/cosca-core-outcome-set-for-cardiac-arrest-in-adults-an-advisory-statement-from-the-international-liaison-committee-on-resuscitation
#13
Kirstie Haywood, Laura Whitehead, Vinay M Nadkarni, Felix Achana, Stefanie Beesems, Bernd W Böttiger, Anne Brooks, Maaret Castrén, Marcus E H Ong, Mary Fran Hazinski, Rudolph W Koster, Gisela Lilja, John Long, Koenraad G Monsieurs, Peter T Morley, Laurie Morrison, Graham Nichol, Valentino Oriolo, Gustavo Saposnik, Michael Smyth, Ken Spearpoint, Barry Williams, Gavin D Perkins
Cardiac arrest effectiveness trials have traditionally reported outcomes that focus on survival. A lack of consistency in outcome reporting between trials limits the opportunities to pool results for meta-analysis. The COSCA initiative (Core Outcome Set for Cardiac Arrest), a partnership between patients, their partners, clinicians, research scientists, and the International Liaison Committee on Resuscitation, sought to develop a consensus core outcome set for cardiac arrest for effectiveness trials. Core outcome sets are primarily intended for large, randomised clinical effectiveness trials (sometimes referred to as pragmatic trials or phase III/IV trials) rather than for pilot or efficacy studies...
April 25, 2018: Resuscitation
https://www.readbyqxmd.com/read/29700122/cosca-core-outcome-set-for-cardiac-arrest-in-adults-an-advisory-statement-from-the-international-liaison-committee-on-resuscitation
#14
REVIEW
Kirstie Haywood, Laura Whitehead, Vinay M Nadkarni, Felix Achana, Stefanie Beesems, Bernd W Böttiger, Anne Brooks, Maaret Castrén, Marcus Eh Ong, Mary Fran Hazinski, Rudolph W Koster, Gisela Lilja, John Long, Koenraad G Monsieurs, Peter T Morley, Laurie Morrison, Graham Nichol, Valentino Oriolo, Gustavo Saposnik, Michael Smyth, Ken Spearpoint, Barry Williams, Gavin D Perkins
Cardiac arrest effectiveness trials have traditionally reported outcomes that focus on survival. A lack of consistency in outcome reporting between trials limits the opportunities to pool results for meta-analysis. The COSCA initiative (Core Outcome Set for Cardiac Arrest), a partnership between patients, their partners, clinicians, research scientists, and the International Liaison Committee on Resuscitation, sought to develop a consensus core outcome set for cardiac arrest for effectiveness trials. Core outcome sets are primarily intended for large, randomized clinical effectiveness trials (sometimes referred to as pragmatic trials or phase III/IV trials ) rather than for pilot or efficacy studies...
April 26, 2018: Circulation
https://www.readbyqxmd.com/read/29693431/maximum-heart-rate-does-not-limit-cardiac-output-at-rest-or-during-exercise-in-the-american-alligator-alligator-mississippiensis
#15
William Joyce, Ruth M Elsey, Tobias Wang, Dane A Crossley Nd
In most vertebrates, increases in cardiac output result from increases in heart rate (fH ) with little or no change in stroke volume (Vs), and maximum cardiac output (Q̇) is typically attained at or close to maximum fH . We therefore tested the hypothesis that increasing maximum fH may increase maximum Q̇. To this end, we investigated the effects of elevating fH with right atrial pacing on Q̇ in the American alligator (Alligator mississippiensis) at rest and whilst swimming. During normal swimming, Q̇ increased entirely by virtue of a tachycardia (29 {plus minus} 1 to 40 {plus minus} 3 beats min-1 ) whilst Vs remained stable...
April 25, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29691270/combining-high-sensitivity-cardiac-troponin-i-and-cardiac-troponin-t-in-the-early-diagnosis-of-acute-myocardial-infarction
#16
Noreen van der Linden, Karin Wildi, Raphael Twerenbold, John W Pickering, Martin Than, Louise Cullen, Jaimi Greenslade, William Parsonage, Thomas Nestelberger, Jasper Boeddinghaus, Patrick Badertscher, Maria Rubini Giménez, Lieke J J Klinkenberg, Otto Bekers, Aline Schöni, Dagmar I Keller, Zaid Sabti, Christian Puelacher, Janosch Cupa, Lukas Schumacher, Nikola Kozhuharov, Karin Grimm, Samyut Shrestha, Dayana Flores, Michael Freese, Claudia Stelzig, Ivo Strebel, Òscar Miró, Katharina Rentsch, Beata Morawiec, Damian Kawecki, Wanda Kloos, Jens Lohrmann, A Mark Richards, Richard Troughton, Christopher Pemberton, Stefan Osswald, Marja P van Dieijen-Visser, Alma M Mingels, Tobias Reichlin, Steven J R Meex, Christian Mueller
Background -Combining two signals of cardiomyocyte injury, cardiac troponin I (cTnI) and T (cTnT), might overcome some individual pathophysiological and analytical limitations and thereby increase diagnostic accuracy for acute myocardial infarction (AMI) with a single blood draw. We aimed to evaluate the diagnostic performance of combinations of high sensitivity (hs) cTnI and hs-cTnT for the early diagnosis of AMI. Methods -The diagnostic performance of combining hs-cTnI (Architect, Abbott) and hs-cTnT (Elecsys, Roche) concentrations (sum, product, ratio and a combination algorithm) obtained at the time of presentation was evaluated in a large multicenter diagnostic study of patients with suspected AMI...
April 24, 2018: Circulation
https://www.readbyqxmd.com/read/29674497/plasma-cell-proliferative-index-predicts-outcome-in-immunoglobulin-light-chain-amyloidosis-treated-with-stem-cell-transplantation
#17
M Hasib Sidiqi, Mohammed Aljama, Dragan Jevremovic, William G Morice, Michael Timm, Francis K Buadi, Rahma Warsame, Martha Q Lacy, Angela Dispenzieri, David Dingli, Wilson I Gonsalves, Shaji Kumar, Prashant Kapoor, Taxiarchis Kourelis, Nelson Leung, William J Hogan, Morie Gertz
The plasma cell proliferative index provides an insight into plasma cell biology in plasma cell disorders and is an important prognostic marker in myeloma and smoldering myeloma. We analyzed the prognostic impact of the plasma cell proliferative index in 513 patients with systemic AL Amyloidosis undergoing stem cell transplantation at the Mayo Clinic between January 2003 and 31 August 2016. Two cohorts were identified; Low or Elevated plasma cell proliferative index. Patients with an Elevated plasma cell proliferative index had more cardiac involvement (56% vs 44%; p=0...
April 19, 2018: Haematologica
https://www.readbyqxmd.com/read/29655877/endocrine-and-haemodynamic-changes-in-resistant-hypertension-and-blood-pressure-responses-to-spironolactone-or-amiloride-the-pathway-2-mechanisms-substudies
#18
Bryan Williams, Thomas M MacDonald, Steve V Morant, David J Webb, Peter Sever, Gordon T McInnes, Ian Ford, J Kennedy Cruickshank, Mark J Caulfield, Sandosh Padmanabhan, Isla S Mackenzie, Jackie Salsbury, Morris J Brown
BACKGROUND: In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did three substudies to assess the mechanisms underlying this superiority and the pathogenesis of resistant hypertension. METHODS: PATHWAY-2 was a randomised, double-blind crossover trial done at 14 UK primary and secondary care sites in 314 patients with resistant hypertension. Patients were given 12 weeks of once daily treatment with each of placebo, spironolactone 25-50 mg, bisoprolol 5-10 mg, and doxazosin 4-8 mg and the change in home systolic blood pressure was assessed as the primary outcome...
April 11, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29655539/month-long-cardiac-surgery-boot-camp-a-proposal-to-jumpstart-resident-training
#19
EDITORIAL
Jonathan C Nesbitt, Nicole M Michaud, Annika Brakebill, Stephen A Deppen, Phillip Williams
No abstract text is available yet for this article.
March 17, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29615521/contribution-of-active-atrial-contraction-to-cardiac-output-in-anesthetized-american-alligators-alligator-mississippiensis
#20
William Joyce, Janna Crossley, Ruth M Elsey, Tobias Wang, Dane A Crossley
Ventricular filling may occur directly from the venous circulation during early diastole or via atrial contraction in late diastole. The contribution of atrial contraction to ventricular filling is typically small in mammals (10-40%), but has been suggested to predominate in reptiles. We investigated the importance of atrial contraction in filling of the ventricle in American alligators ( Alligator mississippiensis ) by bypassing both atria (with the use of ligatures to prevent atrial filling) and measuring the resultant effects on cardiac output in anesthetized animals...
April 30, 2018: Journal of Experimental Biology
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