keyword
https://read.qxmd.com/read/31580479/not-your-grandparents-cardiac-care-the-future-of-geriatric-cardiology
#21
EDITORIAL
Nanette K Wenger, Karen P Alexander
No abstract text is available yet for this article.
February 2020: Clinical Cardiology
https://read.qxmd.com/read/31543188/gender-disparities-in-cardiac-rehabilitation-among-older-women-key-opportunities-to-improve-care
#22
REVIEW
Bianca W Yoo, Nanette K Wenger
Older women with cardiovascular disease experience lower referral, participation, and completion rates of cardiac rehabilitation (CR), despite its well-established benefits (improved morbidity, mortality, quality of life, and functional capacity). Multiple social and health care system barriers affect participation of this population, including limitations in accessibility and transportation, competing responsibilities as caregivers, and lack of insight among patients and provider regarding the value of CR...
November 2019: Clinics in Geriatric Medicine
https://read.qxmd.com/read/31200756/hypertonic-saline-for-fluid-resuscitation-after-cardiac-surgery-heracles-study-protocol-for-a-preliminary-randomised-controlled-clinical-trial
#23
JOURNAL ARTICLE
Carmen A Pfortmueller, Anna S Messmer, Benjamin Hess, David Reineke, Laura Jakob, Stefanie Wenger, Jan Waskowski, Patrick Zuercher, Frederik Stoehr, Gabor Erdoes, Markus M Luedi, Stephan M Jakob, Lars Englberger, Joerg C Schefold
BACKGROUND: Intraoperative and postoperative management of cardiac surgery patients is complex, involving the application of differential vasopressors and volume therapy. It has been shown that a positive fluid balance has a major impact on postoperative outcome. Today, the advantages and disadvantages of buffered crystalloid solutes are a topic of controversy, with no consensus being reached so far. The use of hypertonic saline (HS) has shown promising results with respect to lower total fluid balance and postoperative weight gain in critically ill patients in preliminary studies...
June 14, 2019: Trials
https://read.qxmd.com/read/31045955/code-team-structure-and-training-in-the-pediatric-resuscitation-quality-international-collaborative
#24
JOURNAL ARTICLE
Stephen Pfeiffer, Kasper Glerup Lauridsen, Jesse Wenger, Elizabeth A Hunt, Sarah Haskell, Dianne L Atkins, Jordan M Duval-Arnould, Lynda J Knight, Adam Cheng, Elaine Gilfoyle, Felice Su, Shilpa Balikai, Sophie Skellett, Mok Yee Hui, Dana E Niles, Joan S Roberts, Vinay M Nadkarni, Ken Tegtmeyer, Maya Dewan
OBJECTIVES: Code team structure and training for pediatric in-hospital cardiac arrest are variable. There are no data on the optimal structure of a resuscitation team. The objective of this study is to characterize the structure and training of pediatric code teams in sites participating in the Pediatric Resuscitation Quality Collaborative. METHODS: From May to July 2017, an anonymous voluntary survey was distributed to 18 sites in the international Pediatric Resuscitation Quality Collaborative...
August 1, 2021: Pediatric Emergency Care
https://read.qxmd.com/read/30995683/outcome-of-inter-hospital-transfer-of-patients-on-extracorporeal-membrane-oxygenation-in-switzerland
#25
JOURNAL ARTICLE
Markus J Wilhelm, Devdas Thomas Inderbitzin, Diana Reser, Maximilian Halbe, Koen Van Tillburg, Roland Albrecht, Stefan M Müller, Urs Wenger, Marco Maggiorini, Alain Rudiger, Dominique Bettex, Reto Schüpbach, Alberto Weber, Stefano Benussi, Ludwig K Von Segesser, Andreas J Flammer, Francesco Maisano, Frank Ruschitzka
AIMS OF THE STUDY: An extracorporeal membrane oxygenation system (ECMO), as a bridge to either recovery, a ventricular assist device (VAD), or heart or lung transplantation, may be the only lifesaving option for critically ill patients suffering from refractory cardiac, respiratory or combined cardiopulmonary failure. As peripheral hospitals may not offer ECMO treatment, tertiary care centres provide specialised ECMO teams for on-site implantation and subsequent patient transfer on ECMO to the tertiary hospital...
April 8, 2019: Swiss Medical Weekly
https://read.qxmd.com/read/30516110/gender-differences-in-atrial-fibrillation-a-review-of-epidemiology-management-and-outcomes
#26
REVIEW
Stacy Westerman, Nanette Wenger
Atrial fibrillation is the most common sustained cardiac arrhythmia. The scope and impact of atrial fibrillation are wide; it can affect cardiac function, functional status, and quality of life, and it confers a stroke risk. There are sex differences in atrial fibrillation across the scope of the disease process, from epidemiology and causative mechanisms to management and outcomes. The approach to management of atrial fibrillation differs between women and men, and there are sex differences in response to medical therapy and catheter ablation...
2019: Current Cardiology Reviews
https://read.qxmd.com/read/30217377/feasibility-of-a-smartphone-enabled-cardiac-rehabilitation-program-in-male-veterans-with-previous-clinical-evidence-of-coronary-heart-disease
#27
JOURNAL ARTICLE
Arash Harzand, Bradley Witbrodt, Michelle L Davis-Watts, Alaaeddin Alrohaibani, David Goese, Nanette K Wenger, Amit J Shah, Abarmard Maziar Zafari
Cardiac rehabilitation (CR) is recommended for patients with coronary heart disease, however, participation among veterans remains poor. Smartphones may facilitate data transfer and communication between patients and providers, among other benefits. We evaluated the feasibility of a smartphone-enabled CR program in a population of veterans. Qualifying veterans were prospectively enrolled in a single-arm, nonrandomized feasibility study of a smartphone-enabled, home-based CR program, featuring an app with daily reminders to exercise, log vitals, and review educational materials...
November 1, 2018: American Journal of Cardiology
https://read.qxmd.com/read/30055033/nonreentrant-atrial-tachycardia-occurs-independently-of-hypertrophic-cardiomyopathy-in-rasopathy-patients
#28
JOURNAL ARTICLE
Mark D Levin, Sulagna C Saitta, Karen W Gripp, Tara L Wenger, Jaya Ganesh, Jennifer M Kalish, Michael R Epstein, Rosemarie Smith, Richard J Czosek, Stephanie M Ware, Paula Goldenberg, Angela Myers, Kathryn C Chatfield, Matthew J Gillespie, Elaine H Zackai, Angela E Lin
Multifocal atrial tachycardia (MAT) has a well-known association with Costello syndrome, but is rarely described with related RAS/MAPK pathway disorders (RASopathies). We report 11 patients with RASopathies (Costello, Noonan, and Noonan syndrome with multiple lentigines [formerly LEOPARD syndrome]) and nonreentrant atrial tachycardias (MAT and ectopic atrial tachycardia) demonstrating overlap in cardiac arrhythmia phenotype. Similar overlap is seen in RASopathies with respect to skeletal, musculoskeletal and cutaneous abnormalities, dysmorphic facial features, and neurodevelopmental deficits...
August 2018: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/29451958/peripartum-cardiomyopathy-status-2018
#29
REVIEW
Divya Gupta, Nanette K Wenger
Peripartum cardiomyopathy is a rare cardiac condition, overall. However, in certain populations can be found frequently enough and the signs, symptoms, and management should be readily understood. Here we provide an updated overview of this topic.
February 2018: Clinical Cardiology
https://read.qxmd.com/read/29065887/computed-tomography-of-the-thorax-in-rabbits-a-prospective-study-in-ten-clinically-healthy-new-zealand-white-rabbits
#30
JOURNAL ARTICLE
Désirée Müllhaupt, Sandra Wenger, Patrick Kircher, Nadja Pfammatter, Jean-Michel Hatt, Stefanie Ohlerth
BACKGROUND: Literature investigating the normal cross-sectional anatomy of rabbits with computed tomography (CT) is sparse and incomplete. The purpose of the present study was to investigate the normal thoracic structures, in particular the cranial thorax, with CT angiography in 10 clinically healthy New Zealand White (NZW) rabbits. RESULTS: Absolute and relative measurements of the trachea, heart, thoracic caudal vena cava and aorta, right and left principal bronchi, right and left caudal lobar bronchi and the accompanying branches of the right and left pulmonary artery and vein, right and left lung volume and lung density were taken...
October 24, 2017: Acta Veterinaria Scandinavica
https://read.qxmd.com/read/28933782/cardiovascular-disease-in-the-eastern-mediterranean-region-epidemiology-and-risk-factor-burden
#31
REVIEW
Karam Turk-Adawi, Nizal Sarrafzadegan, Ibtihal Fadhil, Kathryn Taubert, Masoumeh Sadeghi, Nanette K Wenger, Nigel S Tan, Sherry L Grace
The Eastern Mediterranean region (EMR) comprises 22 countries or territories spanning from Morocco in the west to Pakistan in the east, and contains a population of almost 600 million people. Like many other developing regions, the burden of disease in the EMR has shifted in the past 30 years from primarily communicable diseases to noncommunicable diseases such as cardiovascular disease (CVD). Cardiovascular mortality in the EMR, mostly attributable to ischaemic heart disease, is expected to increase more dramatically in the next decade than in any other region except Africa...
February 2018: Nature Reviews. Cardiology
https://read.qxmd.com/read/28640241/long-read-genome-sequencing-identifies-causal-structural-variation-in-a-mendelian-disease
#32
JOURNAL ARTICLE
Jason D Merker, Aaron M Wenger, Tam Sneddon, Megan Grove, Zachary Zappala, Laure Fresard, Daryl Waggott, Sowmi Utiramerur, Yanli Hou, Kevin S Smith, Stephen B Montgomery, Matthew Wheeler, Jillian G Buchan, Christine C Lambert, Kevin S Eng, Luke Hickey, Jonas Korlach, James Ford, Euan A Ashley
PurposeCurrent clinical genomics assays primarily utilize short-read sequencing (SRS), but SRS has limited ability to evaluate repetitive regions and structural variants. Long-read sequencing (LRS) has complementary strengths, and we aimed to determine whether LRS could offer a means to identify overlooked genetic variation in patients undiagnosed by SRS.MethodsWe performed low-coverage genome LRS to identify structural variants in a patient who presented with multiple neoplasia and cardiac myxomata, in whom the results of targeted clinical testing and genome SRS were negative...
January 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://read.qxmd.com/read/27807794/low-testosterone-in-men-with-cardiovascular-disease-or-risk-factors-to-treat-or-not-to-treat
#33
REVIEW
Dimitri C Cassimatis, Matthew T Crim, Nanette K Wenger
Current evidence supports the use of testosterone replacement in men with the clinical-biochemical syndrome of hypogonadism, defined as low testosterone serum levels and symptoms such as fatigue, exercise intolerance, erectile dysfunction, low libido, or depression. Although the evidence consistently shows that hypogonadism is associated with elevated cardiovascular risk, evidence is mixed regarding whether testosterone (T) replacement provides cardiovascular (CV) benefit or harm. For a man with symptomatic hypogonadism in the setting of CV disease, clinical heart failure, and/or traditional CV risk factors (hypertension, diabetes, and hyperlipidemia), a balanced approach would be to counsel him that overall, the evidence should not dissuade him from utilizing T replacement for non-cardiac symptom relief but that more data are needed before a definitive recommendation can be made about T replacement for CV benefit...
December 2016: Current Treatment Options in Cardiovascular Medicine
https://read.qxmd.com/read/27329430/reduction-of-carbamylated-albumin-by-extended-hemodialysis
#34
JOURNAL ARTICLE
Jeffrey Perl, Sahir Kalim, Ron Wald, Marc B Goldstein, Andrew T Yan, Nazanin Noori, Mercedeh Kiaii, Julia Wenger, Christopher Chan, Ravi I Thadhani, S Ananth Karumanchi, Anders H Berg
Introduction Among conventional hemodialysis (CHD) patients, carbamylated serum albumin (C-Alb) correlates with urea and amino acid deficiencies and is associated with mortality. We postulated that reduction of C-Alb by intensive HD may correlate with improvements in protein metabolism and cardiac function. Methods One-year observational study of in-center nocturnal extended hemodialysis (EHD) patients and CHD control subjects. Thirty-three patients receiving 4-hour CHD who converted to 8-hour EHD were enrolled, along with 20 controls on CHD...
October 2016: Hemodialysis International
https://read.qxmd.com/read/27311062/pericardial-fat-and-right-ventricular-morphology-the-multi-ethnic-study-of-atherosclerosis-right-ventricle-study-mesa-rv
#35
MULTICENTER STUDY
David S Wenger, Steven M Kawut, Jingzhong Ding, David A Bluemke, Catherine L Hough, Richard A Kronmal, Joao A Lima, Peter J Leary
BACKGROUND: Pericardial fat has been implicated in the pathogenesis of obesity-related cardiovascular disease. Proposed mechanisms may be relevant in right heart failure, but relationships between pericardial fat and right ventricular (RV) morphology have not been explored. METHODS: The Multi-Ethnic Study of Atherosclerosis is a prospective cohort that enrolled participants without clinical cardiovascular disease. Pericardial fat was measured using computed tomography and RV parameters using cardiac MRI...
2016: PloS One
https://read.qxmd.com/read/27113052/circulating-antiangiogenic-factors-and-myocardial-dysfunction-in-hypertensive-disorders-of-pregnancy
#36
JOURNAL ARTICLE
Sajid Shahul, Diego Medvedofsky, Julia B Wenger, Junaid Nizamuddin, Samuel M Brown, Surichhya Bajracharya, Saira Salahuddin, Ravi Thadhani, Ariel Mueller, Avery Tung, Roberto M Lang, Zoltan Arany, Daniel Talmor, S Ananth Karumanchi, Sarosh Rana
Hypertensive disorders of pregnancy (HDP) are associated with subclinical changes in cardiac function. Although the mechanism underlying this finding is unknown, elevated levels of soluble antiangiogenic proteins such as soluble fms-like tyrosine kinase-1 (sFlt1) and soluble endoglin (sEng) are associated with myocardial dysfunction and may play a role. We hypothesized that these antiangiogenic proteins may contribute to the development of cardiac dysfunction in HDP. We prospectively studied 207 pregnant women with HDP and nonhypertensive controls and evaluated whether changes in global longitudinal strain (GLS) observed on echocardiography is specific for HDP and whether these changes correlate with HDP biomarkers, sFlt1 and sEng...
June 2016: Hypertension
https://read.qxmd.com/read/26940556/relation-between-change-in-renal-function-and-cardiovascular-outcomes-in-atorvastatin-treated-patients-from-the-treating-to-new-targets-tnt-study
#37
MULTICENTER STUDY
James Shepherd, Andrei Breazna, Prakash C Deedwania, John C LaRosa, Nanette K Wenger, Michael Messig, Daniel J Wilson
Statins may have nephroprotective as well as cardioprotective effects in patients with cardiovascular disease. In the Treating to New Targets (TNT) study (NCT00327691), patients with coronary heart disease (CHD) were randomized to atorvastatin 10 or 80 mg/day and followed for 4.9 years. The relation between intrastudy change in estimated glomerular filtration rate (eGFR) from baseline and the risk of major cardiovascular events (MCVEs, defined as CHD death, nonfatal non-procedure-related myocardial infarction, resuscitated cardiac arrest, or fatal or nonfatal stroke) was assessed among 9,500 patients stratified by renal function: improving (change in eGFR more than +2 ml/min/1...
April 15, 2016: American Journal of Cardiology
https://read.qxmd.com/read/26361161/what-to-expect-from-the-evolving-field-of-geriatric-cardiology
#38
REVIEW
Susan P Bell, Nicole M Orr, John A Dodson, Michael W Rich, Nanette K Wenger, Kay Blum, John Gordon Harold, Mary E Tinetti, Mathew S Maurer, Daniel E Forman
The population of older adults is expanding rapidly, and aging predisposes to cardiovascular disease. The principle of patient-centered care must respond to the preponderance of cardiac disease that now occurs in combination with the complexities of old age. Geriatric cardiology melds cardiovascular perspectives with multimorbidity, polypharmacy, frailty, cognitive decline, and other clinical, social, financial, and psychological dimensions of aging. Although some assume that a cardiologist may instinctively cultivate some of these skills over the course of a career, we assert that the volume and complexity of older cardiovascular patients in contemporary practice warrants a more direct approach to achieve suitable training and a more reliable process of care...
September 15, 2015: Journal of the American College of Cardiology
https://read.qxmd.com/read/25933358/lacosamide-cardiac-safety-clinical-trials-in-patients-with-partial-onset-seizures
#39
RANDOMIZED CONTROLLED TRIAL
G D Rudd, W Haverkamp, J W Mason, T Wenger, G Jay, D Hebert, P Doty, R Horstmann
OBJECTIVE: To evaluate the cardiac safety of adjunctive lacosamide in a large pool of adults with partial-onset seizures (POS). METHODS: Post-randomization changes from baseline for electrocardiographic (ECG) measurements, diagnostic findings, and relevant adverse events (AEs) were compared for pooled data from three randomized, placebo-controlled trials of adjunctive lacosamide for the treatment of POS. RESULTS: Lacosamide did not prolong the QTc interval or affect heart rate as determined by an analysis of data from patients randomized to lacosamide 200, 400, or 600 mg/day (n = 944) compared with placebo (n = 364)...
November 2015: Acta Neurologica Scandinavica
https://read.qxmd.com/read/25671766/protein-carbamylation-is-associated-with-heart-failure-and-mortality-in-diabetic-patients-with-end-stage-renal-disease
#40
RANDOMIZED CONTROLLED TRIAL
Christiane Drechsler, Sahir Kalim, Julia B Wenger, Pirianthini Suntharalingam, Tammy Hod, Ravi I Thadhani, S Ananth Karumanchi, Christoph Wanner, Anders H Berg
Serum carbamylated albumin (C-Alb) levels are associated with excess mortality in patients with diabetic end-stage renal disease. To gain insight into the pathophysiology of carbamylation, we determined associations between C-Alb and causes of death in patients on chronic hemodialysis. The Die Deutsche Diabetes Dialyse Studie (4D study) was a randomized controlled trial testing the effects of atorvastatin on survival in diabetic patients on dialysis during a median follow-up of 4 years. We stratified 1161 patients by C-Alb to see whether differences in carbamylation altered the effects of atorvastatin on survival...
June 2015: Kidney International
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