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https://www.readbyqxmd.com/read/27807794/low-testosterone-in-men-with-cardiovascular-disease-or-risk-factors-to-treat-or-not-to-treat
#1
REVIEW
Dimitri C Cassimatis, Matthew T Crim, Nanette K Wenger
Current evidence supports the use of testosterone replacement in men with the clinical-biochemical syndrome of hypogonadism, defined as low testosterone serum levels and symptoms such as fatigue, exercise intolerance, erectile dysfunction, low libido, or depression. Although the evidence consistently shows that hypogonadism is associated with elevated cardiovascular risk, evidence is mixed regarding whether testosterone (T) replacement provides cardiovascular (CV) benefit or harm. For a man with symptomatic hypogonadism in the setting of CV disease, clinical heart failure, and/or traditional CV risk factors (hypertension, diabetes, and hyperlipidemia), a balanced approach would be to counsel him that overall, the evidence should not dissuade him from utilizing T replacement for non-cardiac symptom relief but that more data are needed before a definitive recommendation can be made about T replacement for CV benefit...
December 2016: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27329430/reduction-of-carbamylated-albumin-by-extended-hemodialysis
#2
Jeffrey Perl, Sahir Kalim, Ron Wald, Marc B Goldstein, Andrew T Yan, Nazanin Noori, Mercedeh Kiaii, Julia Wenger, Christopher Chan, Ravi I Thadhani, S Ananth Karumanchi, Anders H Berg
Introduction Among conventional hemodialysis (CHD) patients, carbamylated serum albumin (C-Alb) correlates with urea and amino acid deficiencies and is associated with mortality. We postulated that reduction of C-Alb by intensive HD may correlate with improvements in protein metabolism and cardiac function. Methods One-year observational study of in-center nocturnal extended hemodialysis (EHD) patients and CHD control subjects. Thirty-three patients receiving 4-hour CHD who converted to 8-hour EHD were enrolled, along with 20 controls on CHD...
June 21, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27311062/pericardial-fat-and-right-ventricular-morphology-the-multi-ethnic-study-of-atherosclerosis-right-ventricle-study-mesa-rv
#3
David S Wenger, Steven M Kawut, Jingzhong Ding, David A Bluemke, Catherine L Hough, Richard A Kronmal, Joao A Lima, Peter J Leary
BACKGROUND: Pericardial fat has been implicated in the pathogenesis of obesity-related cardiovascular disease. Proposed mechanisms may be relevant in right heart failure, but relationships between pericardial fat and right ventricular (RV) morphology have not been explored. METHODS: The Multi-Ethnic Study of Atherosclerosis is a prospective cohort that enrolled participants without clinical cardiovascular disease. Pericardial fat was measured using computed tomography and RV parameters using cardiac MRI...
2016: PloS One
https://www.readbyqxmd.com/read/27113052/circulating-antiangiogenic-factors-and-myocardial-dysfunction-in-hypertensive-disorders-of-pregnancy
#4
Sajid Shahul, Diego Medvedofsky, Julia B Wenger, Junaid Nizamuddin, Samuel M Brown, Surichhya Bajracharya, Saira Salahuddin, Ravi Thadhani, Ariel Mueller, Avery Tung, Roberto M Lang, Zoltan Arany, Daniel Talmor, S Ananth Karumanchi, Sarosh Rana
Hypertensive disorders of pregnancy (HDP) are associated with subclinical changes in cardiac function. Although the mechanism underlying this finding is unknown, elevated levels of soluble antiangiogenic proteins such as soluble fms-like tyrosine kinase-1 (sFlt1) and soluble endoglin (sEng) are associated with myocardial dysfunction and may play a role. We hypothesized that these antiangiogenic proteins may contribute to the development of cardiac dysfunction in HDP. We prospectively studied 207 pregnant women with HDP and nonhypertensive controls and evaluated whether changes in global longitudinal strain (GLS) observed on echocardiography is specific for HDP and whether these changes correlate with HDP biomarkers, sFlt1 and sEng...
June 2016: Hypertension
https://www.readbyqxmd.com/read/26940556/relation-between-change-in-renal-function-and-cardiovascular-outcomes-in-atorvastatin-treated-patients-from-the-treating-to-new-targets-tnt-study
#5
MULTICENTER STUDY
James Shepherd, Andrei Breazna, Prakash C Deedwania, John C LaRosa, Nanette K Wenger, Michael Messig, Daniel J Wilson
Statins may have nephroprotective as well as cardioprotective effects in patients with cardiovascular disease. In the Treating to New Targets (TNT) study (NCT00327691), patients with coronary heart disease (CHD) were randomized to atorvastatin 10 or 80 mg/day and followed for 4.9 years. The relation between intrastudy change in estimated glomerular filtration rate (eGFR) from baseline and the risk of major cardiovascular events (MCVEs, defined as CHD death, nonfatal non-procedure-related myocardial infarction, resuscitated cardiac arrest, or fatal or nonfatal stroke) was assessed among 9,500 patients stratified by renal function: improving (change in eGFR more than +2 ml/min/1...
April 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/26361161/what-to-expect-from-the-evolving-field-of-geriatric-cardiology
#6
REVIEW
Susan P Bell, Nicole M Orr, John A Dodson, Michael W Rich, Nanette K Wenger, Kay Blum, John Gordon Harold, Mary E Tinetti, Mathew S Maurer, Daniel E Forman
The population of older adults is expanding rapidly, and aging predisposes to cardiovascular disease. The principle of patient-centered care must respond to the preponderance of cardiac disease that now occurs in combination with the complexities of old age. Geriatric cardiology melds cardiovascular perspectives with multimorbidity, polypharmacy, frailty, cognitive decline, and other clinical, social, financial, and psychological dimensions of aging. Although some assume that a cardiologist may instinctively cultivate some of these skills over the course of a career, we assert that the volume and complexity of older cardiovascular patients in contemporary practice warrants a more direct approach to achieve suitable training and a more reliable process of care...
September 15, 2015: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/25933358/lacosamide-cardiac-safety-clinical-trials-in-patients-with-partial-onset-seizures
#7
RANDOMIZED CONTROLLED TRIAL
G D Rudd, W Haverkamp, J W Mason, T Wenger, G Jay, D Hebert, P Doty, R Horstmann
OBJECTIVE: To evaluate the cardiac safety of adjunctive lacosamide in a large pool of adults with partial-onset seizures (POS). METHODS: Post-randomization changes from baseline for electrocardiographic (ECG) measurements, diagnostic findings, and relevant adverse events (AEs) were compared for pooled data from three randomized, placebo-controlled trials of adjunctive lacosamide for the treatment of POS. RESULTS: Lacosamide did not prolong the QTc interval or affect heart rate as determined by an analysis of data from patients randomized to lacosamide 200, 400, or 600 mg/day (n = 944) compared with placebo (n = 364)...
November 2015: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/25671766/protein-carbamylation-is-associated-with-heart-failure-and-mortality-in-diabetic-patients-with-end-stage-renal-disease
#8
RANDOMIZED CONTROLLED TRIAL
Christiane Drechsler, Sahir Kalim, Julia B Wenger, Pirianthini Suntharalingam, Tammy Hod, Ravi I Thadhani, S Ananth Karumanchi, Christoph Wanner, Anders H Berg
Serum carbamylated albumin (C-Alb) levels are associated with excess mortality in patients with diabetic end-stage renal disease. To gain insight into the pathophysiology of carbamylation, we determined associations between C-Alb and causes of death in patients on chronic hemodialysis. The Die Deutsche Diabetes Dialyse Studie (4D study) was a randomized controlled trial testing the effects of atorvastatin on survival in diabetic patients on dialysis during a median follow-up of 4 years. We stratified 1161 patients by C-Alb to see whether differences in carbamylation altered the effects of atorvastatin on survival...
June 2015: Kidney International
https://www.readbyqxmd.com/read/25637322/impact-of-female-sex-on-lipid-lowering-clinical-outcomes-and-adverse-effects-in-atorvastatin-trials
#9
RANDOMIZED CONTROLLED TRIAL
Priscilla Y Hsue, Vera A Bittner, John Betteridge, Rana Fayyad, Rachel Laskey, Nanette K Wenger, David D Waters
The aim of this study was to evaluate the effect of atorvastatin on lipid lowering, cardiovascular (CV) events, and adverse events in women compared with men in 6 clinical trials. In the Incremental Decrease in End Points Through Aggressive Lipid Lowering (IDEAL) trial (atorvastatin 80 mg vs simvastatin 20 to 40 mg), the Treating to New Targets (TNT) trial (atorvastatin 80 vs 10 mg), the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial (atorvastatin 80 mg vs placebo), and the Collaborative Atorvastatin Diabetes Study (CARDS), the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT), and the Atorvastatin Study for Prevention of Coronary Heart Disease Endpoints in Non-Insulin-Dependent Diabetes Mellitus (ASPEN) (atorvastatin 10 mg vs placebo), lipid changes on treatment were compared between genders with studies grouped by dose...
February 15, 2015: American Journal of Cardiology
https://www.readbyqxmd.com/read/25634839/cardiac-rehabilitation-and-risk-reduction-time-to-rebrand-and-reinvigorate
#10
REVIEW
Pratik B Sandesara, Cameron T Lambert, Neil F Gordon, Gerald F Fletcher, Barry A Franklin, Nanette K Wenger, Laurence Sperling
Atherosclerotic cardiovascular disease (ASCVD) continues to increase annually in the United States along with its associated enormous costs. A multidisciplinary cardiac rehabilitation (CR) and risk reduction program is an essential component of ASCVD prevention and management. Despite the strong evidence for CR in the secondary prevention of ASCVD, it remains vastly underutilized due to significant barriers. The current model of CR delivery is unsustainable and needs significant improvement to provide cost-effective, patient-centered, comprehensive secondary ASCVD prevention...
February 3, 2015: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/25531109/prediction-of-cardiovascular-events-in-statin-treated-stable-coronary-patients-of-the-treating-to-new-targets-randomized-controlled-trial-by-lipid-and-non-lipid-biomarkers
#11
RANDOMIZED CONTROLLED TRIAL
Benoit J Arsenault, Philip Barter, David A DeMicco, Weihang Bao, Gregory M Preston, John C LaRosa, Scott M Grundy, Prakash Deedwania, Heiner Greten, Nanette K Wenger, James Shepherd, David D Waters, John J P Kastelein
UNLABELLED: Several plasma non-lipid biomarkers have been shown to predict major cardiovascular events (MCVEs) in population studies. Our objective was to investigate the relationship between lipid and non-lipid biomarkers levels achieved during statin therapy and the incidence of MCVEs in patients with stable coronary heart disease (CHD). We conducted a substudy of the TNT (Treating to New Targets) study, which was a randomized trial that compared the efficacy of high (80 mg) versus low (10 mg) dose atorvastatin for the secondary prevention of CHD...
2014: PloS One
https://www.readbyqxmd.com/read/25453985/ischemic-heart-disease-in-women-a-focus-on-risk-factors
#12
REVIEW
Puja K Mehta, Janet Wei, Nanette K Wenger
Heart disease remains a major contributor to morbidity and mortality in women in the United States and worldwide. This review highlights known and emerging risk factors for ischemic heart disease (IHD) in women. Traditional Framingham risk factors such as hypertension, hyperlipidemia, diabetes, smoking, as well as lifestyle habits such as unhealthy diet and sedentary lifestyle are all modifiable. Health care providers should be aware of emerging cardiac risk factors in women such as adverse pregnancy outcomes, systemic autoimmune disorders, obstructive sleep apnea, and radiation-induced heart disease; psychosocial factors such as mental stress, depression, anxiety, low socioeconomic status, and work and marital stress play an important role in IHD in women...
February 2015: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/25123255/charge-like-presentation-craniosynostosis-and-mild-mowat-wilson-syndrome-diagnosed-by-recognition-of-the-distinctive-facial-gestalt-in-a-cohort-of-28-new-cases
#13
Tara L Wenger, Margaret Harr, Stefania Ricciardi, Elizabeth Bhoj, Avni Santani, Margaret P Adam, Sarah S Barnett, Rebecca Ganetzky, Donna M McDonald-McGinn, Domenica Battaglia, Stefania Bigoni, Angelo Selicorni, Giovanni Sorge, Matteo Della Monica, Francesca Mari, Elena Andreucci, Silvia Romano, Guido Cocchi, Salvatore Savasta, Baris Malbora, Giuseppe Marangi, Livia Garavelli, Marcella Zollino, Elaine H Zackai
Mowat-Wilson syndrome (MWS) is characterized by moderate to severe intellectual disability and distinctive facial features in association with variable structural congenital anomalies/clinical features including congenital heart disease, Hirschsprung disease, hypospadias, agenesis of the corpus callosum, short stature, epilepsy, and microcephaly. Less common clinical features include ocular anomalies, craniosynostosis, mild intellectual disability, and choanal atresia. These cases may be more difficult to diagnose...
October 2014: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/25047587/role-of-noninvasive-testing-in-the-clinical-evaluation-of-women-with-suspected-ischemic-heart-disease-a-consensus-statement-from-the-american-heart-association
#14
Jennifer H Mieres, Martha Gulati, Noel Bairey Merz, Daniel S Berman, Thomas C Gerber, Sharonne N Hayes, Christopher M Kramer, James K Min, L Kristin Newby, J V Ian Nixon, Monvadi B Srichai, Patricia A Pellikka, Rita F Redberg, Nanette K Wenger, Leslee J Shaw
No abstract text is available yet for this article.
July 22, 2014: Circulation
https://www.readbyqxmd.com/read/23816975/fatty-acids-and-other-risk-factors-for-sudden-cardiac-death-in-patients-starting-hemodialysis
#15
Allon N Friedman, Zhangsheng Yu, Cheryl Denski, Hector Tamez, Julia Wenger, Ravi Thadhani, Yong Li, Bruce Watkins
BACKGROUND: Little is known about risk factors for sudden cardiac death in hemodialysis patients during the high-risk first year of dialysis. We therefore undertook to identify such risk factors in a nationally representative cohort and were able to include baseline levels of blood fatty acids, some of which influence arrhythmogenicity and sudden cardiac death risk. DESIGN: The study cohort included 100 patients who died of sudden cardiac death during the first year of hemodialysis and 300 frequency-matched controls...
2013: American Journal of Nephrology
https://www.readbyqxmd.com/read/23716745/comparison-of-patient-simulation-methods-used-in-a-physical-assessment-course
#16
COMPARATIVE STUDY
Gloria R Grice, Philip Wenger, Natalie Brooks, Tricia M Berry
OBJECTIVE: To determine whether there is a difference in student pharmacists' learning or satisfaction when standardized patients or manikins are used to teach physical assessment. DESIGN: Third-year student pharmacists were randomized to learn physical assessment (cardiac and pulmonary examinations) using either a standardized patient or a manikin. ASSESSMENT: Performance scores on the final examination and satisfaction with the learning method were compared between groups...
May 13, 2013: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/23617837/pretransplant-dyslipidaemia-determines-outcome-in-lung-transplant-recipients
#17
Urs Wenger, Silvia R Cottini, Georg Noll, Stefan Arndt, Paul A Stehberger, Stefanie Klinzing, Reto A Schuepbach, Markus B├ęchir
BACKGROUND: There is little knowledge about the effect of dyslipidaemia on the outcome after lung transplantation. Thus, the aim of this retrospective single centre study was to analyse the impact of the plasma lipid profile on mortality in lung transplant recipients. From January 2000 to December 2008 the charts of 172 consecutive lung transplantation recipients were analysed. At baseline and after one year lipid profiles were routinely collected. During the follow-up major cardiovascular events (MCE; beginning of dialysis, cerebrovascular insult or myocardial infarction) were recorded...
2013: Lipids in Health and Disease
https://www.readbyqxmd.com/read/23389417/inverse-relationship-between-long-chain-n-3-fatty-acids-and-risk-of-sudden-cardiac-death-in-patients-starting-hemodialysis
#18
Allon N Friedman, Zhangsheng Yu, Rebeka Tabbey, Cheryl Denski, Hector Tamez, Julia Wenger, Ravi Thadhani, Yong Li, Bruce A Watkins
Experimental and clinical evidence suggests that long-chain n-3 fatty acids may protect against sudden cardiac death, the leading cause of mortality in hemodialysis patients. Here we investigated whether long-chain n-3 fatty acids have a protective relationship with sudden cardiac death in 100 patients who died of sudden cardiac death during the first year of starting hemodialysis and 300 patients who survived. Individuals were selected from a nationally representative cohort of over 1000 US hemodialysis units in 2004-2005...
June 2013: Kidney International
https://www.readbyqxmd.com/read/23254246/cardiac-rehabilitation-and-cardiovascular-disability-role-in-assessment-and-improving-functional-capacity-a-position-statement-from-the-american-association-of-cardiovascular-and-pulmonary-rehabilitation
#19
REVIEW
Larry F Hamm, Nanette K Wenger, Ross Arena, Daniel E Forman, Carl J Lavie, Todd D Miller, Randal J Thomas
The Social Security Administration (SSA) oversees the disability determination process and the payment of disability benefits to Americans. According to recent SSA data, approximately 900 000 persons are receiving cardiovascular disability payments and about 145 000 adult claims for cardiovascular disability are processed by the SSA annually. An objective and comprehensive examination of functional capacity is an important part of the disability assessment process. This statement reviews various protocols for disability assessment of aerobic capacity, muscle function, and the physical requirements of job tasks...
January 2013: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/23194491/vitamin-d-reduces-left-atrial-volume-in-patients-with-left-ventricular-hypertrophy-and-chronic-kidney-disease
#20
RANDOMIZED CONTROLLED TRIAL
Hector Tamez, Carmine Zoccali, David Packham, Julia Wenger, Ishir Bhan, Evan Appelbaum, Yili Pritchett, Yuchiao Chang, Rajiv Agarwal, Christoph Wanner, Donald Lloyd-Jones, Jorge Cannata, B Taylor Thompson, Dennis Andress, Wuyan Zhang, Bhupinder Singh, Daniel Zehnder, Ajay Pachika, Warren J Manning, Amil Shah, Scott D Solomon, Ravi Thadhani
BACKGROUND: Left atrial enlargement, a sensitive integrator of left ventricular diastolic function, is associated with increased cardiovascular morbidity and mortality. Vitamin D is linked to lower cardiovascular morbidity, possibly modifying cardiac structure and function; however, firm evidence is lacking. We assessed the effect of an activated vitamin D analog on left atrial volume index (LAVi) in a post hoc analysis of the PRIMO trial (clinicaltrials.gov: NCT00497146). METHODS AND RESULTS: One hundred ninety-six patients with chronic kidney disease (estimated glomerular filtration rate 15-60 mL/min per 1...
December 2012: American Heart Journal
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