keyword
MENU ▼
Read by QxMD icon Read
search

Biochemical

keyword
https://www.readbyqxmd.com/read/28655130/comparison-of-biochemical-parameters-of-blood-and-urine-in-spinal-cord-injury-patients-and-association-with-urinary-stone-formation
#1
Gülümser Aydin, Sibel Özbudak Demir, Timur Ekiz, Murat I Nanir, Aliye Tosun
OBJECTIVE: The aim of this study was to compare the biochemical parameters of the urine and blood in SCI patients and healthy subjects. METHODS: Thirty male patients with SCI were enrolled. Biochemical features of the urine and blood of the SCI patients were compared to healthy subjects. Extracted stones were analyzed by X-ray diffraction. RESULTS: A total of 30 patients with SCI (mean age of 28.77 ± 7.3 years) and 10 healthy subjects (mean age of 27...
June 3, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28655082/-impact-of-the-2016-new-definition-and-classification-system-of-pancreatic-fistula-on-the-evaluation-of-pancreatic-fistula-after-pancreatic-surgery
#2
X L Han, J Xu, W M Wu, M H Dai, T P Zhang, Q Liao, G Chen, J C Guo, W B Wang, L Cong, Y P Zhao
Objective: To discuss the impact of updated definition and classification system of pancreatic fistula published in 2016 on the postoperative classification of pancreatic fistula. Methods: Retrospective analysis was made on patients who underwent pancreatic surgery at ward 1 in Department of General Surgery, Peking Union Medical College Hospital from January 2015 to December 2016.A total of 408 patients were included in this retrospective study, male/female was 184/224, aged from 9 to 81 years with mean age of 51...
July 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28654861/aging-alters-mrna-expression-of-amyloid-transporter-genes-at-the-blood-brain-barrier
#3
Doreen Osgood, Miles C Miller, Arthur A Messier, Liliana Gonzalez, Gerald D Silverberg
Decreased clearance of potentially toxic metabolites, due to aging changes, likely plays a significant role in the accumulation of amyloid-beta (Aβ) peptides and other macromolecules in the brain of the elderly and in the patients with Alzheimer's disease (AD). Aging is the single most important risk factor for AD development. Aβ transport receptor proteins expressed at the blood-brain barrier are significantly altered with age: the efflux transporters lipoprotein receptor-related protein 1 and P-glycoprotein are reduced, whereas the influx transporter receptor for advanced glycation end products is increased...
May 19, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28654754/potential-strategies-to-target-protein-protein-interactions-in-the-dna-damage-response-and-repair-pathways
#4
Naoaki Fujii
This review article discusses some insights about generating novel mechanistic inhibitors of the DNA damage response and repair (DDR) pathways by focusing on protein-protein interactions (PPIs) of the key DDR components. General requirements for PPI strategies, such as selecting the target PPI site on the basis of its functionality, are discussed first. Next, based on functional rationale and biochemical feasibility to identify a PPI inhibitor, 26 PPIs in DDR pathways (BER, MMR, NER, NHEJ, HR, TLS, and ICL repair) are specifically discussed for inhibitor discovery to benefit cancer therapies using a DNA-damaging agent...
June 27, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28654704/2-5-hexanedione-downregulates-nerve-growth-factor-and-induces-neuron-apoptosis-in-the-spinal-cord-of-rats-via-inhibition-of-the-pi3k-akt-signaling-pathway
#5
Zhemin Wang, Zewen Qiu, Chenxue Gao, Yijie Sun, Wei Dong, Yan Zhang, Ruolin Chen, Yuan Qi, Shuangyue Li, Yanjie Guo, Yongjun Piao, Sheng Li, Fengyuan Piao
2,5-hexanedione (2,5-HD) is the main active metabolite of n-hexane and induces apoptosis in nerve tissue, however, the mechanism of which remains unclear. In the present study, neuropathic animal models were successfully constructed in rats by injecting 100, 200 and 400 mg/kg 2,5-HD intraperitoneally for 5 weeks. Rats exposed to 2,5-HD exhibited progressive gait abnormalities and slower motor neural response in a dose-dependent manner. TUNEL analysis and immunofluorescence dual labeling revealed that the spinal cord of the 2,5-HD treated rats underwent significantly more apoptosis in the cells of spinal cord than that of the control group...
2017: PloS One
https://www.readbyqxmd.com/read/28654652/alleviation-of-the-effects-of-saline-alkaline-stress-on-maize-seedlings-by-regulation-of-active-oxygen-metabolism-by-trichoderma-asperellum
#6
Jian Fu, Zhihua Liu, Zuotong Li, Yufeng Wang, Kejun Yang
This study investigated the influence of Trichoderma asperellum on active oxygen production in maize seedlings under saline-alkaline stress conditions. Two maize cultivars were tested: 'Jiangyu 417' ('JY417'), which can tolerate saline-alkaline stress; and, 'Xianyu 335' ('XY335'), which is sensitive to saline-alkaline stress. The seedlings were grown on natural saline-alkaline soil (pH 9.30) in plastic pots. To each liter of saline-alkaline soil, 200 mL of T. asperellum spore suspension was applied; three fungal suspensions were used, namely, 1 × 103, 1 × 106, and 1 × 109 spores/L...
2017: PloS One
https://www.readbyqxmd.com/read/28654641/biological-effects-of-the-hypomagnetic-field-an-analytical-review-of-experiments-and-theories
#7
Vladimir N Binhi, Frank S Prato
During interplanetary flights in the near future, a human organism will be exposed to prolonged periods of a hypomagnetic field that is 10,000 times weaker than that of Earth's. Attenuation of the geomagnetic field occurs in buildings with steel walls and in buildings with steel reinforcement. It cannot be ruled out also that a zero magnetic field might be interesting in biomedical studies and therapy. Further research in the area of hypomagnetic field effects, as shown in this article, is capable of shedding light on a fundamental problem in biophysics-the problem of primary magnetoreception...
2017: PloS One
https://www.readbyqxmd.com/read/28654554/baseline-hepatitis-b-virus-titer-predicts-initial-postpartum-hepatic-flare-a-multicenter-prospective-study
#8
Jinfeng Liu, Jing Wang, Caijing Qi, Furong Cao, Zhen Tian, Dandan Guo, Taotao Yan, Qian Li, Shujuan Yang, JianJun Fu, Xianmei Tang, Xiaoni Kou, Na Liu, Zicheng Jiang, Yingren Zhao, Tianyan Chen
BACKGROUND AND GOALS: A series of changes in the immune system occur during pregnancy and puerperium. Currently, we aim to characterize both the natural changes in liver inflammation and its association with hepatitis B viremia during this special period. PATIENTS AND METHODS: Chronic hepatitis B (CHB) gravidas were recruited and followed up to 52 weeks postpartum. Virological and biochemical parameters were assessed throughout the period. RESULTS: A total of 1097 CHB mothers had finished the entire follow-up including 451 accepting telbivudine, 178 accepting tenofovir, and 468 without antiviral therapy...
June 26, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28654324/conceptual-and-experimental-tools-to-understand-spatial-effects-and-transport-phenomena-in-nonlinear-biochemical-networks-illustrated-with-patchy-switching
#9
Rebecca R Pompano, Andrew H Chiang, Christian J Kastrup, Rustem F Ismagilov
Many biochemical systems are spatially heterogeneous and exhibit nonlinear behaviors, such as state switching in response to small changes in the local concentration of diffusible molecules. Systems as varied as blood clotting, intracellular calcium signaling, and tissue inflammation are all heavily influenced by the balance of rates of reaction and mass transport phenomena including flow and diffusion. Transport of signaling molecules is also affected by geometry and chemoselective confinement via matrix binding...
June 20, 2017: Annual Review of Biochemistry
https://www.readbyqxmd.com/read/28654223/the-pomegranate-punica-granatum-l-genome-and-the-genomics-of-punicalagin-biosynthesis
#10
Gaihua Qin, Chunyan Xu, Ray Ming, Haibao Tang, Romain Guyot, Elena M Kramer, Yudong Hu, Xingkai Yi, Yongjie Qi, Xiangyang Xu, Zhenghui Gao, Haifa Pan, Jianbo Jian, Yinping Tian, Zhen Yue, Yiliu Xu
Pomegranate (Punica granatum L.) is a perennial fruit crop grown since ancient times that has been planted worldwide and is known for its functional metabolites, particularly punicalagins. We have sequenced and assembled the pomegranate genome with 328 Mb anchored into nine pseudo-chromosomes and annotated 29 229 gene models. A Myrtales lineage-specific whole-genome duplication (WGD) event was detected that occurred in the common ancestor before the divergence of pomegranate and Eucalyptus. Repetitive sequences accounted for 46...
June 27, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28654204/race-and-risk-of-metastases-and-survival-after-radical-prostatectomy-results-from-the-search-database
#11
Stephen J Freedland, Adriana C Vidal, Lauren E Howard, Martha K Terris, Matthew R Cooperberg, Christopher L Amling, Christopher J Kane, William J Aronson
BACKGROUND: Black race is associated with prostate cancer (PC) diagnosis and poor outcome. Previously, the authors reported that black men undergoing radical prostatectomy (RP) in equal-access hospitals had an increased risk of biochemical disease recurrence (BCR), but recurrences were equally aggressive as those occurring in white men. The authors examined the association between race and long-term outcomes after RP. METHODS: Data regarding 1665 black men (37%) and 2791 white men (63%) undergoing RP were analyzed...
June 27, 2017: Cancer
https://www.readbyqxmd.com/read/28654103/the-development-of-anticancer-ruthenium-ii-complexes-from-single-molecule-compounds-to-nanomaterials
#12
REVIEW
Leli Zeng, Pranav Gupta, Yanglu Chen, Enju Wang, Liangnian Ji, Hui Chao, Zhe-Sheng Chen
Cancer is rapidly becoming the top killer in the world. Most of the FDA approved anticancer drugs are organic molecules, while metallodrugs are very scarce. The advent of the first metal based therapeutic agent, cisplatin, launched a new era in the application of transition metal complexes for therapeutic design. Due to their unique and versatile biochemical properties, ruthenium-based compounds have emerged as promising anti-cancer agents that serve as alternatives to cisplatin and its derivertives. Ruthenium(iii) complexes have successfully been used in clinical research and their mechanisms of anticancer action have been reported in large volumes over the past few decades...
June 27, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28654036/in-ovo-electroporation-in-the-chicken-auditory-brainstem
#13
Ting Lu, Ariel Loren Cohen, Jason Tait Sanchez
Electroporation is a method that introduces genes of interest into biologically relevant organisms like the chicken embryo. It is long established that the chicken embryo is an effective research model for studying basic biological functions of auditory system development. More recently, the chicken embryo has become particularly valuable in studying gene expression, regulation and function associated with hearing. In ovo electroporation can be used to target auditory brainstem regions responsible for highly specialized auditory functions...
June 9, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28654031/treatment-of-ligament-constructs-with-exercise-conditioned-serum-a-translational-tissue-engineering-model
#14
Ann Lee-Barthel, Keith Baar, Daniel W D West
In vitro experiments are essential to understand biological mechanisms; however, the gap between monolayer tissue culture and human physiology is large, and translation of findings is often poor. Thus, there is ample opportunity for alternative experimental approaches. Here we present an approach in which human cells are isolated from human anterior cruciate ligament tissue remnants, expanded in culture, and used to form engineered ligaments. Exercise alters the biochemical milieu in the blood such that the function of many tissues, organs and bodily processes are improved...
June 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28653934/evaluation-of-nephroprotective-activity-of-musa-paradisiaca-l-in-gentamicin-induced-nephrotoxicity
#15
Khizar Abbas, Ghazala H Rizwani, Hina Zahid, M Imran Qadir
The objective of the study was to investigate the nephroprotective activity of methanolic extract of different morphological parts (bract, flower, trachea and tracheal fluid) of Musa paradisiaca L. (Family: Musaceae) against gentamicin-induced nephrotoxicity in mice. Gentamicin produced significant changes in biochemical (increased levels of blood urea nitrogen level, blood urea, and serum creatinine), and histological parameters in mice. Treatment with methanolic extract of bract (100 and 250mg/kg, b.w) and flowering stalk (trachea) (250 and 500mg/kg, b...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28653933/comparative-studies-on-rabbit-plasma-lipid-profile-fed-with-silybum-marianum-oil-sunflower-oil-and-vegetable-ghee
#16
Ghosia Lutfullah, Azizur Rahman, Aftab Ahmad, Taufiq Ahmad, Amjad Ali, Jan Alam
Present work is aimed to compare the physicochemical characterization and biochemical effects of oil extracted from Silybum Marianum and Sunflower oil, collected from Peshawar (Pakistan). To investigate the comparative effects on the body weight, organ weight and lipid profile, the crude oil of Silybum marianum, edible sunflower oil and vegetable ghee were given to three groups of rabbits under study. Percent proximate composition and food consumption of all rabbits were determined which showed no significant statistical variation...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28653915/protective-role-of-sargassum-species-in-liver-and-kidney-dysfunctions-and-associated-disorders-in-rats-intoxicated-with-carbon-tetrachloride-and-acetaminophen
#17
Khan Hira, Viqar Sultana, Jehan Ara, Syed Ehteshamul Haque
Hepatoprotective and reno-potective effect of Sargassum species was investigated in rats against carbon tetrachloride (CCl4) and acetaminophen (AAP) intoxication. The rats were given ethanol extracts of Sargassum ilicifolium, S. lanceolatum and S.swartzii orally at dose of 200mg/kg b.w. (body weight) daily for 14 days. These seaweed treated rats were then intoxicated with single intra-peritoneal dose of CCl4 or AAP on14th day. The administration of CCl4 and AAP caused significant (p<0.05) elevation in liver enzymes; alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and other biochemical parameters, bilirubin, glucose, triglyceride and kidney function markers: urea and creatinine...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28653811/biochemical-characterization-of-medaka-oryzias-latipes-orthologue-for-mammalian-factor-xiii-and-establishment-of-gene-edited-mutant
#18
Rima Horimizu, Ryota Ogawa, Yuko Watanabe, Hideki Tatsukawa, Masato Kinoshita, Hisashi Hashimoto, Kiyotaka Hitomi
At the final process of blood coagulation, fibrin molecules are stabilized via a catalytic reaction by Factor XIIIA (FXIIIA), one of the family members of transglutaminase (TGase) that catalyzes protein cross-linking reactions. In this study, we characterized the orthologue of this enzyme in medaka (Oryzias latipes), an established model fish in which a coagulation system is also preserved. The recombinant protein of this orthologue enzyme was produced in baculovirus-infected insect cells and used for biochemical property analysis including activation by thrombin-proteolysis and calcium-dependence of the TGase enzymatic activity...
June 27, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28653701/identification-of-actin-as-a-direct-proteomic-target-of-berberine-using-an-affinity-based-chemical-probe-and-elucidation-of-its-modulatory-role-in-actin-assembly
#19
Chae-Min Yi, Jihyun Yu, Hyunbin Kim, Na-Rae Lee, Sang Won Kim, Noh-Jin Lee, Jun Lee, Jihye Seong, Nam-Jung Kim, Kyung-Soo Inn
Despite the diverse pharmacological activities of berberine, including anti-cancer and anti-inflammatory effects, the direct proteomic targets of berberine have remained largely unknown. Here, we have identified actin as a direct proteomic target of berberine using an affinity-based chemical probe. In addition, we found that actin assembly was significantly modulated by berberine in vitro at the biochemical level and cellular level.
June 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28653671/a-dynamic-and-adaptive-network-of-cytosolic-interactions-governs-protein-export-by-the-t3ss-injectisome
#20
Andreas Diepold, Erdinc Sezgin, Miles Huseyin, Thomas Mortimer, Christian Eggeling, Judith P Armitage
Many bacteria use a type III secretion system (T3SS) to inject effector proteins into host cells. Selection and export of the effectors is controlled by a set of soluble proteins at the cytosolic interface of the membrane spanning type III secretion 'injectisome'. Combining fluorescence microscopy, biochemical interaction studies and fluorescence correlation spectroscopy, we show that in live Yersinia enterocolitica bacteria these soluble proteins form complexes both at the injectisome and in the cytosol. Binding to the injectisome stabilizes these cytosolic complexes, whereas the free cytosolic complexes, which include the type III secretion ATPase, constitute a highly dynamic and adaptive network...
June 27, 2017: Nature Communications
keyword
keyword
7420
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"