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S Weiss cardiac

Jessica Weiss, Michele Freeman, Allison Low, Rochelle Fu, Amy Kerfoot, Robin Paynter, Makalapua Motu'apuaka, Karli Kondo, Devan Kansagara
Background: Recent guidelines recommend a systolic blood pressure (SBP) goal of less than 150 mm Hg for adults aged 60 years or older, but the balance of benefits and harms is unclear in light of newer evidence. Purpose: To systematically review the effects of more versus less intensive BP control in older adults. Data Sources: Multiple databases through January 2015 and MEDLINE to September 2016. Study Selection: 21 randomized, controlled trials comparing BP targets or treatment intensity, and 3 observational studies that assessed harms...
March 21, 2017: Annals of Internal Medicine
Lucas V Boersma, Craig S Barr, Martin C Burke, Angel R Leon, Dominic A Theuns, John M Herre, Raul Weiss, Mark S Kremers, Petr Neuzil, Michael P Husby, Nathan Carter, Timothy M Stivland, Michael R Gold
BACKGROUND: The subcutaneous implantable defibrillator (S-ICD) provides an alternative to the transvenous ICD for the prevention of sudden cardiac death, but has not been well studied in the most commonly treated transvenous ICD patient population, namely, primary prevention (PP) patients with left ventricular dysfunction. OBJECTIVE: The analyses in the present study were designed to compare clinical outcomes for PP patients with and without a reduced ejection fraction (EF) and secondary prevention (SP) patients implanted with the S-ICD...
November 24, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Pradeep Natarajan, Joshua C Bis, Lawrence F Bielak, Amanda J Cox, Marcus Dörr, Mary F Feitosa, Nora Franceschini, Xiuqing Guo, Shih-Jen Hwang, Aaron Isaacs, Min A Jhun, Maryam Kavousi, Ruifang Li-Gao, Leo-Pekka Lyytikäinen, Riccardo E Marioni, Ulf Schminke, Nathan O Stitziel, Hayato Tada, Jessica van Setten, Albert V Smith, Dina Vojinovic, Lisa R Yanek, Jie Yao, Laura M Yerges-Armstrong, Najaf Amin, Usman Baber, Ingrid B Borecki, J Jeffrey Carr, Yii-Der Ida Chen, L Adrienne Cupples, Pim A de Jong, Harry de Koning, Bob D de Vos, Ayse Demirkan, Valentin Fuster, Oscar H Franco, Mark O Goodarzi, Tamara B Harris, Susan R Heckbert, Gerardo Heiss, Udo Hoffmann, Albert Hofman, Ivana Išgum, J Wouter Jukema, Mika Kähönen, Sharon L R Kardia, Brian G Kral, Lenore J Launer, Joe Massaro, Roxana Mehran, Braxton D Mitchell, Thomas H Mosley, Renée de Mutsert, Anne B Newman, Khanh-Dung Nguyen, Kari E North, Jeffrey R O'Connell, Matthijs Oudkerk, James S Pankow, Gina M Peloso, Wendy Post, Michael A Province, Laura M Raffield, Olli T Raitakari, Dermot F Reilly, Fernando Rivadeneira, Frits Rosendaal, Samantha Sartori, Kent D Taylor, Alexander Teumer, Stella Trompet, Stephen T Turner, Andre G Uitterlinden, Dhananjay Vaidya, Aad van der Lugt, Uwe Völker, Joanna M Wardlaw, Christina L Wassel, Stefan Weiss, Mary K Wojczynski, Diane M Becker, Lewis C Becker, Eric Boerwinkle, Donald W Bowden, Ian J Deary, Abbas Dehghan, Stephan B Felix, Vilmundur Gudnason, Terho Lehtimäki, Rasika Mathias, Dennis O Mook-Kanamori, Bruce M Psaty, Daniel J Rader, Jerome I Rotter, James G Wilson, Cornelia M van Duijn, Henry Völzke, Sekar Kathiresan, Patricia A Peyser, Christopher J O'Donnell
BACKGROUND: The burden of subclinical atherosclerosis in asymptomatic individuals is heritable and associated with elevated risk of developing clinical coronary heart disease. We sought to identify genetic variants in protein-coding regions associated with subclinical atherosclerosis and the risk of subsequent coronary heart disease. METHODS AND RESULTS: We studied a total of 25 109 European ancestry and African ancestry participants with coronary artery calcification (CAC) measured by cardiac computed tomography and 52 869 participants with common carotid intima-media thickness measured by ultrasonography within the CHARGE Consortium (Cohorts for Heart and Aging Research in Genomic Epidemiology)...
December 2016: Circulation. Cardiovascular Genetics
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
T Jared Bunch, Heidi T May, Tami L Bair, Brian G Crandall, Michael J Cutler, Victoria Jacobs, Charles Mallender, Joseph B Muhlestein, Jeffrey S Osborn, J Peter Weiss, John D Day
BACKGROUND: Catheter ablation of atrial fibrillation (AF) is an established therapeutic rhythm approach in symptomatic patients. Obesity is a dominant driver of AF recurrence after ablation. However, being both overweight and underweight drives long-term cardiac and general health risks. Long-term data are needed to understand the influence of body mass index (BMI) on outcomes after ablation in regard to arrhythmia recurrence and cardiovascular outcomes. METHODS: All patients who underwent an index ablation with a BMI recorded and at least 3 years of follow-up were included (n = 1558)...
September 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Peter J Leary, Ryan J Tedford, David A Bluemke, Michael R Bristow, Susan R Heckbert, Steven M Kawut, Eric V Krieger, Joao A Lima, Carolina S Masri, David D Ralph, Steven Shea, Noel S Weiss, Richard A Kronmal
BACKGROUND: Myocardial H2 receptor activation may promote cardiac fibrosis and apoptosis in pre-clinical models and histamine H2 receptor antagonist (H2RA) use may improve symptoms in participants with heart failure (HF); however, relationships between H2RA use, incident HF, and longitudinal change in left ventricular (LV) morphology are not known. OBJECTIVES: This study sought to determine whether H2RA use is associated with incident HF and change in LV morphology over time...
April 5, 2016: Journal of the American College of Cardiology
Sushabhan Sadhukhan, Xiaojing Liu, Dongryeol Ryu, Ornella D Nelson, John A Stupinski, Zhi Li, Wei Chen, Sheng Zhang, Robert S Weiss, Jason W Locasale, Johan Auwerx, Hening Lin
Cellular metabolites, such as acyl-CoA, can modify proteins, leading to protein posttranslational modifications (PTMs). One such PTM is lysine succinylation, which is regulated by sirtuin 5 (SIRT5). Although numerous proteins are modified by lysine succinylation, the physiological significance of lysine succinylation and SIRT5 remains elusive. Here, by profiling acyl-CoA molecules in various mouse tissues, we have discovered that different tissues have different acyl-CoA profiles and that succinyl-CoA is the most abundant acyl-CoA molecule in the heart...
April 19, 2016: Proceedings of the National Academy of Sciences of the United States of America
A Wannhoff, T Hippchen, C S Weiss, K Friedrich, C Rupp, C Neumann-Haefelin, M Dollinger, C Antoni, U Stampfl, P Schemmer, W Stremmel, K H Weiss, B Radeleff, H A Katus, D N Gotthardt
BACKGROUND: Transjugular intrahepatic portosystemic shunt (TIPSS) cause haemodynamic changes in patients with cirrhosis, yet little is known about long-term cardiopulmonary outcomes. AIM: To evaluate the long-term cardiopulmonary outcome after TIPSS. METHODS: We evaluated cardiopulmonary parameters including echocardiography during long-term follow-up after TIPSS. Results at 1-5 years after TIPSS were compared to those of cirrhotic controls...
May 2016: Alimentary Pharmacology & Therapeutics
Marcus R Streit, Celine S Weiss, Sören Meyer, Marco M Ochs, Marco Hagenmueller, Johannes H Riffel, Sebastian J Buss, Thomas Heger, Hugo A Katus, Stefan E Hardt
AIMS: Inhibition of β-adrenergic signalling plays a key role in treatment of heart failure. Gsα is essential for β-adrenergic signal transduction. In order to reduce side-effects of beta-adrenergic inhibition diminishing β-adrenergic signalling in the heart at the level of Gsα is a promising option. METHODS AND RESULTS: We analyzed the influence of Gsα on regulation of myocardial function and development of cardiac hypertrophy, using a transgenic mouse model (C57BL6/J mice) overexpressing a dominant negative Gsα-mutant under control of the α-MHC-promotor...
2016: PloS One
Cristian Pattaro, Martin Gögele, Deborah Mascalzoni, Roberto Melotti, Christine Schwienbacher, Alessandro De Grandi, Luisa Foco, Yuri D'Elia, Barbara Linder, Christian Fuchsberger, Cosetta Minelli, Clemens Egger, Lisa S Kofink, Stefano Zanigni, Torsten Schäfer, Maurizio F Facheris, Sigurður V Smárason, Alessandra Rossini, Andrew A Hicks, Helmuth Weiss, Peter P Pramstaller
The Cooperative Health Research In South Tyrol (CHRIS) study is a population-based study with a longitudinal lookout to investigate the genetic and molecular basis of age-related common chronic conditions and their interaction with life style and environment in the general population. All adults of the middle and upper Vinschgau/Val Venosta are invited, while 10,000 participants are anticipated by mid-2017. Family participation is encouraged for complete pedigree reconstruction and disease inheritance mapping...
November 5, 2015: Journal of Translational Medicine
T Jared Bunch, Heidi T May, Tami L Bair, Victoria Jacobs, Brian G Crandall, Michael Cutler, J Peter Weiss, Charles Mallender, Jeffrey S Osborn, Jeffrey L Anderson, John D Day
BACKGROUND: Catheter ablation of atrial fibrillation (AF) is an established therapeutic rhythm approach in symptomatic patients. Many studies have shown that age has little to no impact on outcomes during the first year after ablation. However, AF is a disease of aging and age-based substrate for arrhythmia is likely to progress. To this regard, we examined patients with 5-year outcome data following an index AF ablation procedure to define the impact of age on long-term outcomes. METHODS: A total of 923 patients that underwent their index AF ablation and had 5 years of follow-up were studied...
February 2016: Journal of Cardiovascular Electrophysiology
Anita D'Souza, Angela Dispenzieri, Baldeep Wirk, Mei-Jie Zhang, Jiaxing Huang, Morie A Gertz, Robert A Kyle, Shaji Kumar, Raymond L Comenzo, Robert Peter Gale, Hillard M Lazarus, Bipin N Savani, Robert F Cornell, Brendan M Weiss, Dan T Vogl, César O Freytes, Emma C Scott, Heather J Landau, Jan S Moreb, Luciano J Costa, Muthalagu Ramanathan, Natalie S Callander, Rammurti T Kamble, Richard F Olsson, Siddhartha Ganguly, Taiga Nishihori, Tamila L Kindwall-Keller, William A Wood, Tomer M Mark, Parameswaran Hari
PURPOSE: Autologous hematopoietic cell transplantation, or autotransplantation, is effective in light-chain amyloidosis (AL), but it is associated with a high risk of early mortality (EM). In a multicenter randomized comparison against oral chemotherapy, autotransplantation was associated with 24% EM. We analyzed trends in outcomes after autologous hematopoietic cell transplantation for AL in North America. PATIENTS AND METHODS: Between 1995 and 2012, 1,536 patients with AL who underwent autotransplantation at 134 centers were identified in the Center for International Blood and Marrow Transplant Research database...
November 10, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Michael Schär, Refaat E Gabr, AbdEl-Monem M El-Sharkawy, Angela Steinberg, Paul A Bottomley, Robert G Weiss
BACKGROUND: Phosphorus saturation transfer (ST) magnetic resonance spectroscopy can measure the rate of ATP generated from phosphocreatine (PCr) via creatine kinase (CK) in the human heart. Recently, the triple-repetition time ST (TRiST) method was introduced to measure the CK pseudo-first-order rate constant kf in three acquisitions. In TRiST, the longitudinal relaxation time of PCr while γ-ATP is saturated, T1`, is measured for each subject, but suffers from low SNR because the PCr signal is reduced due to exchange with saturated γ-ATP, and the short repetition time of one of the acquisitions...
2015: Journal of Cardiovascular Magnetic Resonance
Sietske H Kevelam, Jörgen Bierau, Ramona Salvarinova, Shakti Agrawal, Tomas Honzik, Dennis Visser, Marjan M Weiss, Gajja S Salomons, Truus E M Abbink, Quinten Waisfisz, Marjo S van der Knaap
OBJECTIVE: To identify the etiology of a novel, heritable encephalopathy in a small group of patients. METHODS: Magnetic resonance imaging (MRI) pattern analysis was used to select patients with the same pattern. Homozygosity mapping and whole exome sequencing (WES) were performed to find the causal gene mutations. RESULTS: Seven patients from 4 families (2 consanguineous) were identified with a similar MRI pattern characterized by T2 signal abnormalities and diffusion restriction in the posterior limb of the internal capsule, often also optic radiation, brainstem tracts, and cerebellar white matter, in combination with delayed myelination and progressive brain atrophy...
October 2015: Annals of Neurology
Karin Weiss, Carolyn Applegate, Tao Wang, Denise A S Batista
Haploinsufficiency of TAB2 was recently implicated as a cause for a variety of congenital heart defects. Reported cases have genomic deletions of 2-10 Mbs including TAB2 at 6q24-25 are almost always de novo and show variable cardiac and extra cardiac phenotype. We report on an inherited, 281 kb deletion in a three generation family. This is the smallest reported deletion involving TAB2 that segregates with congenital heart defects. Three affected individuals in this family present with myxomatous cardiac valves in addition to structural heart defects commonly associated with TAB2 deletions...
November 2015: American Journal of Medical Genetics. Part A
Chete M Eze-Nliam, Zugui Zhang, Sandra A Weiss, William S Weintraub
Health care is a vital good for which there is an infinite demand. However, societal resources are finite and need to be distributed efficiently to avoid waste. Thus, the relative value of an intervention - cost compared to its effectiveness- needs to be taken into consideration when deciding which interventions to adopt. Cost-effectiveness analysis provides the crucial information which guides these decisions. As the field of medicine and indeed cardiology move forward with innovations which are effective but often expensive, it becomes imperative to employ these cost-effectiveness analytic tools, not with the intention of denying vital health services but to ascertain what the society willing to pay for...
2014: Interventional Cardiology
Raimund Pechlaner, Stefan Kiechl, Manuel Mayr, Peter Santer, Siegfried Weger, David Haschka, Sukhvinder S Bansal, Johann Willeit, Günter Weiss
BACKGROUND: The expression of the key iron regulatory hormone hepcidin is regulated by iron availability, inflammation, hormones, hypoxia, and anaemia. Increased serum concentrations of hepcidin have recently been linked to atherosclerosis. We studied demographic, haematologic, biochemical, and dietary correlates of serum hepcidin levels and its associations with incident cardiovascular disease and with carotid atherosclerosis. METHODS: Serum hepcidin concentrations were measured by tandem mass spectrometry in samples taken in 2000 from 675 infection-free participants of the prospective population-based Bruneck study (age, mean±standard deviation, 66...
January 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Zaher Fanari, Sandra Weiss, William S Weintraub
Acute coronary syndromes (ACS) are associated with high rates of morbidity and mortality. The advances of antiplatelet and anticoagulation therapy over several years time have resulted in improved in cardiac outcomes, but with increased health care costs. Multiple cost-effectiveness studies have been performed to evaluate the use of available antiplatelet agents and anticoagulation in the setting of both ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation acute coronary syndrome (NSTE-ACS)...
December 2015: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
Roderick Tung, Marmar Vaseghi, David S Frankel, Pasquale Vergara, Luigi Di Biase, Koichi Nagashima, Ricky Yu, Sitaram Vangala, Chi-Hong Tseng, Eue-Keun Choi, Shaan Khurshid, Mehul Patel, Nilesh Mathuria, Shiro Nakahara, Wendy S Tzou, William H Sauer, Kairav Vakil, Usha Tedrow, J David Burkhardt, Venkatakrishna N Tholakanahalli, Anastasios Saliaris, Timm Dickfeld, J Peter Weiss, T Jared Bunch, Madhu Reddy, Arun Kanmanthareddy, David J Callans, Dhanunjaya Lakkireddy, Andrea Natale, Francis Marchlinski, William G Stevenson, Paolo Della Bella, Kalyanam Shivkumar
BACKGROUND: The impact of catheter ablation of ventricular tachycardia (VT) on all-cause mortality remains unknown. OBJECTIVE: The purpose of this study was to examine the association between VT recurrence after ablation and survival in patients with scar-related VT. METHODS: Analysis of 2061 patients with structural heart disease referred for catheter ablation of scar-related VT from 12 international centers was performed. Data on clinical and procedural variables, VT recurrence, and mortality were analyzed...
September 2015: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Amy C Sturm, Crystal F Kline, Patric Glynn, Benjamin L Johnson, Jerry Curran, Ahmet Kilic, Robert S D Higgins, Philip F Binkley, Paul M L Janssen, Raul Weiss, Subha V Raman, Steven J Fowler, Silvia G Priori, Thomas J Hund, Cynthia A Carnes, Peter J Mohler
BACKGROUND: Identified genetic variants are insufficient to explain all cases of inherited arrhythmia. We tested whether the integration of whole exome sequencing with well-established clinical, translational, and basic science platforms could provide rapid and novel insight into human arrhythmia pathophysiology and disease treatment. METHODS AND RESULTS: We report a proband with recurrent ventricular fibrillation, resistant to standard therapeutic interventions...
May 2015: Journal of the American Heart Association
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