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https://www.readbyqxmd.com/read/28319051/tissue-specific-exosome-biomarkers-for-noninvasively-monitoring-immunologic-rejection-of-transplanted-tissue
#1
Prashanth Vallabhajosyula, Laxminarayana Korutla, Andreas Habertheuer, Ming Yu, Susan Rostami, Chao-Xing Yuan, Sanjana Reddy, Chengyang Liu, Varun Korutla, Brigitte Koeberlein, Jennifer Trofe-Clark, Michael R Rickels, Ali Naji
In transplantation, there is a critical need for noninvasive biomarker platforms for monitoring immunologic rejection. We hypothesized that transplanted tissues release donor-specific exosomes into recipient circulation and that the quantitation and profiling of donor intra-exosomal cargoes may constitute a biomarker platform for monitoring rejection. Here, we have tested this hypothesis in a human-into-mouse xenogeneic islet transplant model and validated the concept in clinical settings of islet and renal transplantation...
March 20, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28242077/ex%C3%A2-vivo-lung-perfusion-model-to-study-pulmonary-tissue-extracellular-microvesicle-profiles
#2
Prashanth Vallabhajosyula, Laxminarayana Korutla, Andreas Habertheuer, Sanjana Reddy, Christian Shaufler, Jared Lasky, Joshua Diamond, Edward Cantu
BACKGROUND: Extracellular microvesicles (EVs) are being increasingly studied for their diagnostic potential. We investigated the feasibility of studying the kinetics and tissue-specific profiles of pulmonary EVs in the context of ex vivo lung perfusion (EVLP) used for salvaging marginal lungs for transplantation. METHODS: Perfusate from six marginal donor lungs placed on EVLP was collected at the following time points: 0, 10, and 60 minutes after and after perfusate exchange with Steen Solution; 120 and 180 minutes...
February 24, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28153346/usefulness-for-predicting-cardiac-events-after-orthotopic-liver-transplantation-of-myocardial-perfusion-imaging-and-dobutamine-stress-echocardiography-preoperatively
#3
David Snipelisky, Jordan Ray, Saraschandra Vallabhajosyula, Gautam Matcha, Samuel Squier, Jacob Lewis, Rex Holliday, Niti Aggarwal, J Wells Askew, Brian Shapiro, Nandan Anavekar
Patients undergoing orthotopic liver transplantation have high rates of cardiac morbidity and mortality. Although guidelines recommend noninvasive stress testing as part of the preoperative evaluation, little data have evaluated clinical outcomes following orthotopic liver transplantation. A retrospective study at 2 high-volume liver transplantation centers was performed. All patients undergoing noninvasive stress testing (myocardial perfusion imaging [MPI] or dobutamine stress echocardiography [DSE]) over a 5-year period were included...
April 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28149858/ventilation-in-acute-respiratory-distress-syndrome-importance-of-low-tidal-volume
#4
EDITORIAL
Saraschandra Vallabhajosyula, Vrinda Trivedi, Ognjen Gajic
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27970206/tct-80-characterizing-the-incidence-and-predictors-of-paravalvular-regurgitation-after-transcatheter-aortic-valve-replacement-tavr-and-its-impact-on-outcomes-a-study-of-the-society-of-thoracic-surgeons-american-college-of-cardiology-transcatheter-valve-therapies
#5
Saif Anwaruddin, Ajay Kirtane, Vinod Thourani, Sreekanth Vemulapalli, Pratik Manandhar, Howard Herrmann, Joseph Bavaria, Jay Giri, Prashanth Vallabhajosyula, Birgitte Krogsgaard Andersen, Wilson Szeto
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27913775/role-of-b-type-natriuretic-peptide-in-predicting-in-hospital-outcomes-in-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-with-preserved-left-ventricular-function
#6
Saraschandra Vallabhajosyula, Toufik Mahfood Haddad, Pranathi R Sundaragiri, Anas A Ahmed, Muhammad Sarfraz Nawaz, Hamza A A Rayes, Harish C Devineni, Arun Kanmanthareddy, Dustin A McCann, Christopher S Wichman, Ariel M Modrykamien, Lee E Morrow
BACKGROUND: The role of B-type natriuretic peptide (BNP) is less understood in the risk stratification of patients with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD), especially in patients with normal left ventricular ejection fraction (LVEF). METHODS: This retrospective study from 2008 to 2012 evaluated all adult patients with AECOPD having BNP levels and available echocardiographic data demonstrating LVEF ≥40%. The patients were divided into groups 1, 2, and 3 with BNP ≤ 100, 101 to 500, and ≥501 pg/mL, respectively...
January 1, 2016: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/27899637/a-genome-wide-dosage-suppressor-network-reveals-genomic-robustness
#7
Biranchi Patra, Yoshiko Kon, Gitanjali Yadav, Anthony W Sevold, Jesse P Frumkin, Ravishankar R Vallabhajosyula, Arend Hintze, Bjørn Østman, Jory Schossau, Ashish Bhan, Bruz Marzolf, Jenna K Tamashiro, Amardeep Kaur, Nitin S Baliga, Elizabeth J Grayhack, Christoph Adami, David J Galas, Alpan Raval, Eric M Phizicky, Animesh Ray
Genomic robustness is the extent to which an organism has evolved to withstand the effects of deleterious mutations. We explored the extent of genomic robustness in budding yeast by genome wide dosage suppressor analysis of 53 conditional lethal mutations in cell division cycle and RNA synthesis related genes, revealing 660 suppressor interactions of which 642 are novel. This collection has several distinctive features, including high co-occurrence of mutant-suppressor pairs within protein modules, highly correlated functions between the pairs and higher diversity of functions among the co-suppressors than previously observed...
January 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27851081/1445-who-can-be-called-elderly-for-severe-sepsis-mortality
#8
Ankit Sakhuja, Gagan Kumar, Saraschandra Vallabhajosyula, Rahul Kashyap, Kianoush Kashani
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27851041/1405-seasonal-variations-in-severe-sepsis-hospitalizations
#9
Ankit Sakhuja, Gagan Kumar, Saraschandra Vallabhajosyula, Kianoush Kashani
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850998/1362-long-term-new-onset-heart-failure-in-patients-with-myocardial-dysfunction-in-sepsis-and-septic-shock
#10
Saraschandra Vallabhajosyula, Jacob Jentzer, Jeffrey Geske, Kianoush Kashani, Ognjen Gajic, Rahul Kashyap
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849859/217-characteristics-of-type-1-cardiorenal-syndrome-during-hospitalization-a-descriptive-analysis
#11
Sandhya Samavedam, Kumar Sarvottam, Saraschandra Vallabhajosyula, Kevin Curwick, Gregory Wilson, Kianoush Kashani, Sunil Mankad, Jacob Jentzer
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849828/185-doppler-defined-acute-pulmonary-hypertension-in-sepsis-and-septic-shock
#12
Saraschandra Vallabhajosyula, Rahul Kashyap, Jeffrey Geske, Ankit Sakhuja, Kianoush Kashani, Jacob Jentzer
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849708/28-right-ventricular-dysfunction-in-sepsis-and-septic-shock-an-eight-year-analysis
#13
Saraschandra Vallabhajosyula, Rahul Kashyap, Jeffrey Geske, Mukesh Kumar, Kianoush Kashani, Jacob Jentzer
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849703/23-cardiorenal-syndrome-in-sepsis-and-septic-shock-the-mayo-clinic-experience
#14
Saraschandra Vallabhajosyula, Jacob Jentzer, Jeffrey Geske, Ankit Sakhuja, Rahul Kashyap, Kianoush Kashani
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27829716/association-of-hyponatremia-with-in-hospital-outcomes-in-infective-endocarditis-a-5-year-review-from-an-indian-intensive-care-unit
#15
Saraschandra Vallabhajosyula, Muralidhar D Varma, Shashaank Vallabhajosyula, Saarwaani Vallabhajosyula
Hyponatremia is commonly noted with cardiovascular disorders, but its role in infective endocarditis (IE) is limited to being a marker of increased morbidity in IE patients with intravenous drug use. This was a 5-year retrospective review from an Indian Intensive Care Unit (ICU). Patients >18 years with IE and available serum sodium levels were included in the study. Pediatric and pregnant patients were excluded from the study. Hyponatremia was defined as admission sodium <135 mmol/L. Detailed data were abstracted from the medical records...
October 2016: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27776336/role-of-statins-in-delirium-prevention-in-critical-ill-and-cardiac-surgery-patients-a-systematic-review-and-meta-analysis
#16
Saraschandra Vallabhajosyula, Arun Kanmanthareddy, Patricia J Erwin, Dennis J Esterbrooks, Lee E Morrow
BACKGROUND: The data evaluating the role of statins in delirium prevention in the intensive care unit are conflicting and limited. METHODS: We performed a systematic review and meta-analysis of literature from 1975 to 2015. All English-language adult studies evaluating delirium incidence in statin and statin nonusers were included and studies without a control group were excluded. Mantel-Haenszel model was used to calculate pooled risk ratios (RRs) and 95% confidence intervals (CIs)...
February 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/27727609/development-of-vascular-complications-and-bladder-carcinoma-in-diabetic-patients-using-pioglitazone
#17
S Vallabhajosyula, S Nair, A Kamath
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27666785/central-repair-with-antegrade-tevar-for-malperfusion-syndromes-in-acute-debakey-i-aortic-dissection
#18
Prashanth Vallabhajosyula, Jean Paul Gottret, Rohan Menon, Ibrahim Sultan, Zara Abbas, Mary Siki, Matthew Kramer, Aaron Pulsipher, Suveeksha Naidu, Alberto Pochettino, Kariana Milewski, Wilson Y Szeto, Joseph E Bavaria
BACKGROUND: In acute DeBakey I aortic dissection presenting with malperfusion syndromes, we assessed whether standard open repair with concomitant antegrade stent grafting (thoracic endovascular aneurysm repair; TEVAR) of the descending thoracic aorta (DTA) improves outcomes compared with standard repair alone. METHODS: From 2005 to 2012, 277 patients with acute DeBakey I dissection underwent emergent operation. Of these, 104 patients (37%) presenting with end-organ malperfusion were divided into those undergoing standard distal repair entailing transverse hemiarch replacement (Standard group, n = 65) versus standard repair with concomitant DTA TEVAR during circulatory arrest (TEVAR group, n = 39)...
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27645983/left-lower-lobe-pulmonary-torsion
#19
Saraschandra Vallabhajosyula, Shanda H Blackmon
No abstract text is available yet for this article.
October 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27621564/right-sided-infective-endocarditis-in-an-indian-intensive-care-unit
#20
Saraschandra Vallabhajosyula, Muralidhar D Varma, Saarwaani Vallabhajosyula, Shashaank Vallabhajosyula
No abstract text is available yet for this article.
July 2016: Journal of Global Infectious Diseases
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