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Gilbert H L Tang, Wilson Y Szeto
No abstract text is available yet for this article.
February 17, 2018: Journal of Thoracic and Cardiovascular Surgery
Waranyoo Phoolcharoen, Ashley C Banyard, Christophe Prehaud, David Selden, Guanghui Wu, Colin P D Birch, Tim H Szeto, Monique Lafon, Anthony R Fooks, Julian K-C Ma
Rabies causes more than 60,000 human deaths annually in areas where the virus is endemic. Importantly, rabies is one of the few pathogens for which there is no treatment following the onset of clinical disease with the outcome of infection being death in almost 100% of cases. Whilst vaccination, and the combination of vaccine and rabies immunoglobulin treatment for post-exposure administration are available, no tools have been identified that can reduce or prevent rabies virus replication once clinical disease has initiated...
March 6, 2018: Vaccine
Fenton H McCarthy, Sreekanth Vemulapalli, Zhuokai Li, Vinod Thourani, Roland A Matsouaka, Nimesh D Desai, Ajay Kirtane, Saif Anwaruddin, Matthew L Williams, Jay Giri, Prashanth Vallabhajosyula, Robert H Li, Howard C Herrmann, Joseph E Bavaria, Wilson Y Szeto
BACKGROUND: The purpose of this study is to evaluate the association of tricuspid regurgitation (TR) severity with outcomes after transcatheter aortic valve replacement (TAVR). METHODS: We analyzed data from 34,576 patients who underwent TAVR at 365 US hospitals from November 2011 through March 2015 submitted to The Society of Thoracic Surgeon/American College of Cardiology Transcatheter Valve Therapy Registry. We examined unadjusted mortality and heart failure readmission stratified by degree of preoperative TR and used multivariable models for 1-year mortality and heart failure readmission...
March 2, 2018: Annals of Thoracic Surgery
Michelle L Delco, Edward D Bonnevie, Hazel S Szeto, Lawrence J Bonassar, Lisa A Fortier
No disease-modifying osteoarthritis (OA) drugs are available to prevent posttraumatic osteoarthritis (PTOA). Mitochondria (MT) mediate the pathogenesis of many degenerative diseases, and recent evidence indicates that MT dysfunction is a peracute (within minutes to hours) response of cartilage to mechanical injury. The goal of this study was to investigate cardiolipin-targeted mitoprotection as a new strategy to prevent chondrocyte death and cartilage degeneration after injury. Cartilage was harvested from bovine knee joints and subjected to a single, rapid impact injury (24...
February 22, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Harini Naidu, Winnie Szeto, Eugene Kissin, Francis A Farraye
No abstract text is available yet for this article.
February 15, 2018: Inflammatory Bowel Diseases
Mei-Hua Bao, Vivian Szeto, Burton B Yang, Shu-Zhen Zhu, Hong-Shuo Sun, Zhong-Ping Feng
Stroke is one of the leading causes of mortality and disability worldwide. Uncovering the cellular and molecular pathophysiological processes in stroke have been a top priority. Long non-coding (lnc) RNAs play critical roles in different kinds of diseases. In recent years, a bulk of aberrantly expressed lncRNAs have been screened out in ischemic stroke patients or ischemia insulted animals using new technologies such as RNA-seq, deep sequencing, and microarrays. Nine specific lncRNAs, antisense non-coding RNA in the INK4 locus (ANRIL), metastasis-associate lung adenocarcinoma transcript 1 (MALAT1), N1LR, maternally expressed gene 3 (MEG3), H19, CaMK2D-associated transcript 1 (C2dat1), Fos downstream transcript (FosDT), small nucleolar RNA host gene 14 (SNHG14), and taurine-upregulated gene 1 (TUG1), were found increased in cerebral ischemic animals and/or oxygen-glucose deprived (OGD) cells...
February 15, 2018: Cell Death & Disease
Xiaoxiong Wang, Yim Tong Szeto, Chengchun Jiang, Xiaojun Wang, Yi Tao, Jianguo Tu, Jing Chen
This study investigated the use of Dracontomelon duperreanum leaf litter extract (DDLLE) in inhibiting the growth and photosynthesis of the algae Microcystis aeruginosa. The goal of the study was to evaluate a potential solution for cyanobacterial bloom prevention. M. aeruginosa was exposed to extract concentrations from 0.4 to 2.0 g L-1. Chlorophyll-a (Chl-a) content and photosynthesis levels were assessed using pulse amplitude modulated fluorimetry phytoplankton analyzer. Results suggested that the extract could efficiently suppress M...
February 13, 2018: Bulletin of Environmental Contamination and Toxicology
Enxuan Jing, Pragalath Sundararajan, Ishita Deb Majumdar, Suwagmani Hazarika, Samantha Fowler, Angela Szeto, Stephane Gesta, Armando J Mendez, Vivek K Vishnudas, Rangaprasad Sarangarajan, Niven R Narain
Background: Inhibition of Hsp90 has been shown to improve glucose tolerance and insulin sensitivity in mouse models of diabetes. In the present report, the specific isoform Hsp90ab1, was identified as playing a major role in regulating insulin signaling and glucose metabolism. Methods: In a diet-induced obese (DIO) mouse model of diabetes, expression of various Hsp90 isoforms in skeletal tissue was examined. Subsequent experiments characterized the role of Hsp90ab1 isoform in glucose metabolism and insulin signaling in primary human skeletal muscle myoblasts (HSMM) and a DIO mouse model...
2018: Nutrition & Metabolism
Yan Fei Xie, Grace Szeto, Pascal Madeleine, Sharon Tsang
To advance our understanding about the association between smartphone use and chronic neck-shoulder pain, the objective of this study was to compare spinal kinematics between different text-entry methods in smartphone users with and without chronic neck-shoulder pain. Symptomatic (n = 19) and healthy participants (n = 18) were recruited and they performed three tasks: texting on a smartphone with one hand, with two hands, and typing on a desktop computer. Three-dimensional kinematics were examined in the cervical, thoracic and lumbar regions for each task...
April 2018: Applied Ergonomics
Kin Cheung, Grace Szeto, Godfrey Kin Bun Lai, Shirley S Y Ching
The prevalence of work-related musculoskeletal symptoms (WRMSs) in different body parts for nursing assistants (NAs) working in nursing homes is currently unknown. The aim of this study was to determine the extent of WRMSs in nursing assistants and the factors associated with them. Four hundred and forty NAs from 52 nursing homes, recruited by convenience sampling, participated in this cross-sectional study in 2014-2015. A valid and reliable study questionnaire was used to collect data. The results of our study found that 88...
February 4, 2018: International Journal of Environmental Research and Public Health
Ibrahim Sultan, Mary A Siki, Joseph E Bavaria, Taylor R Dibble, Danielle C Savino, Arman Kilic, Wilson Szeto, Prashanth Vallabhajosyula, Ronald M Fairman, Benjamin M Jackson, Grace J Wang, Nimesh D Desai
BACKGROUND: Chronic DeBakey III (CD3) aortic dissection is typically managed with open aortic reconstruction. Thoracic endovascular aortic grafting (TEVAR) has been attempted in patients with CD3 with improved outcomes over medical management, however with frequent failures. This study investigates factors associated with positive aortic remodeling from a large aortic center. METHODS: Three dimensional reconstructions (M2S, West Lebanon, NH) of computed tomography angiography scans of 48 patients who underwent TEVAR from 2005 to 2015 were analyzed...
January 29, 2018: Annals of Thoracic Surgery
K Hidayat, G-C Chen, Y Wang, Z Zhang, X Dai, I M Y Szeto, L-Q Qin
BACKGROUND: Older adults experience age-related physiological changes that affect body weight and body composition. In general, nutrition and exercise have been identified as potent stimulators of protein synthesis in skeletal muscle. Milk proteins are excellent sources of all the essential amino acids and may represent an ideal protein source to promote muscle anabolism in older adults undergoing resistance training. However, several randomized control trials (RCTs) have yielded mixed results on the effects of milk proteins supplementation in combination with resistance training on body weight and composition...
2018: Journal of Nutrition, Health & Aging
Danny Dvir, Thierry Bourguignon, Catherine M Otto, Rebecca T Hahn, Raphael Rosenhek, John G Webb, Hendrik Treede, Maurice E Sarano, Ted Feldman, Harindra C Wijeysundera, Yan Topilsky, Michel Aupart, Michael J Reardon, G Burkhard Mackensen, Wilson Y Szeto, Ran Kornowski, James S Gammie, Ajit P Yoganathan, Yaron Arbel, Michael A Borger, Matheus Simonato, Mark Reisman, Raj R Makkar, Alexandre Abizaid, James M McCabe, Gry Dahle, Gabriel S Aldea, Jonathon Leipsic, Philippe Pibarot, Neil E Moat, Michael J Mack, A Pieter Kappetein, Martin B Leon
Bioprostheses are prone to structural valve degeneration, resulting in limited long-term durability. A significant challenge when comparing the durability of different types of bioprostheses is the lack of a standardized terminology for the definition of a degenerated valve. This issue becomes especially important when we try to compare the degeneration rate of surgically inserted and transcatheter bioprosthetic valves. This document, by the VIVID (Valve-in-Valve International Data), proposes practical and standardized definitions of valve degeneration and provides recommendations for the timing of clinical and imaging follow-up assessments accordingly...
January 23, 2018: Circulation
Ho-Pan Hsia, Yin-Hua Yang, Wun-Chung Szeto, Benjamin E Nilsson, Chun-Yeung Lo, Andy Ka-Leung Ng, Ervin Fodor, Pang-Chui Shaw
The influenza virus RNA genome is transcribed and replicated in the context of the viral ribonucleoprotein (vRNP) complex by the viral RNA polymerase. The nucleoprotein (NP) is the structural component of the vRNP providing a scaffold for the viral RNA. In the vRNP as well as during transcription and replication the viral polymerase interacts with NP but it is unclear which parts of the polymerase and NP mediate these interactions. Previously the C-terminal '627' domain (amino acids 538-693) of PB2 was shown to interact with NP...
2018: PloS One
Sharon M H Tsang, Billy C L So, Rufina W L Lau, Jie Dai, Grace P Y Szeto
PURPOSE: This study compared the effects of "Ergomotor" intervention and conventional physiotherapy, on influencing the motor control in the neck-shoulder region in people with work-related neck-shoulder pain (WRNSP). METHODS: 101 patients (age range 20-54 years) diagnosed with chronic WRNSP were randomized into control (CO) group (n = 50) and Ergomotor (EM) group (n = 51). Each group received a 12-week intervention. Participants in CO group received treatment for pain relief and general exercises...
April 2018: European Journal of Applied Physiology
Pascal Zhongping Wei, Bonnie Ching-Ha Kwan, Kai Ming Chow, Phyllis Mei-Shan Cheng, Cathy Choi-Wan Luk, Philip Kam-Tao Li, Cheuk Chun Szeto
Background: Mitochondrial dysfunction plays an important role in the pathogenesis and progression of diabetic nephropathy (DN). We study the relation between urinary and intra-renal mitochondrial deoxyribonucleic acid (mtDNA) levels and renal dysfunction in DN. Methods: We recruited 92 patients with biopsy-proven DN. Urinary sediment, urinary supernatant and intra-renal mtDNA levels were measured and compared with baseline renal biopsy, kidney scarring and renal function decline in the subsequent 24 months...
December 28, 2017: Nephrology, Dialysis, Transplantation
Judy Szeto, Remy Lemoine, Rosary Nguyen, Lori L Olson, Mary J Tanga
[15 N]-Cholamine is an isotope tag for metabolomics research, because it possesses two important properties: an NMR active isotope and a permanent charge for MS sensitivity. Here we present a scalable synthesis of [15 N]-cholamine.
December 26, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
Yingxin Li, Xiaoxiao Zhang, Chen Zhang, Xiaoying Zhang, Ying Li, Zhao Qi, Christopher Szeto, Mingxin Tang, Yizhi Peng, Jeffery D Molkentin, Steven R Houser, Mingxing Xie, Xiongwen Chen
OBJECTIVE: Cav3.1 (α1G ) T-type Ca2+ channel (TTCC) is expressed in mouse sinoatrial node cells (SANCs) and atrioventricular nodal (AVN) cells and contributes to heart rate genesis and AV conduction. However, its role in heart rate (HR) regulation and AV conduction acceleration by the β-adrenergic system (SAS) is unclear, which is the topic of this study. METHODS AND RESULTS: L- (ICa-L ) and T-type (ICa-T ) Ca2+ currents were recorded in SANCs from Cav3.1 transgenic (TG) and knockout (KO), and control mice...
December 23, 2017: Journal of Physiology
Angelo B Biviano, Tamim Nazif, Jose Dizon, Hasan Garan, Mark Abrams, Jessica Fleitman, Dua Hassan, Samir Kapadia, Vasilis Babaliaros, Ke Xu, Josep Rodes-Cabau, Wilson Y Szeto, William F Fearon, Danny Dvir, Todd Dewey, Mathew Williams, Steven Kindsvater, Michael J Mack, John G Webb, D Craig Miller, Craig R Smith, Martin B Leon, Susheel Kodali
Atrial fibrillation (AF) is associated with worse outcomes in many cardiovascular diseases. There are few data examining pacemaker implantation rates and indications in patients with AF who undergo transcatheter aortic valve replacement (TAVR). To examine the impact of AF on the incidence of and indications for pacemakers in patients undergoing TAVR, we evaluated data of 1723 patients without pre-existing pacemakers who underwent TAVR in the Placement of AoRTic TraNscathetER Valve (PARTNER) trial. Permanent pacemaker implantation rates and indications were compared in groups based on baseline and discharge heart rhythm: sinus rhythm (SR) vs...
June 2017: Journal of Atrial Fibrillation
Terry King-Wing Ma, Kai Ming Chow, Bonnie Ching-Ha Kwan, Jack Kit-Chung Ng, Agnes Shin-Man Choy, Vickie Wai-Ki Kwong, Wing-Fai Pang, Chi Bon Leung, Philip Kam-To Li, Cheuk Chun Szeto
BACKGROUND: Catheter malfunction is an important cause of technique failure for peritoneal dialysis (PD) patients, and is commonly managed by surgeons or intervention radiologists. We reviewed our experience in catheter revision or replacement by nephrologists. METHOD: We reviewed the clinical outcome and complication rate of 95 consecutive patients who had PD catheter malfunction, with catheter revision or replacement by nephrologist. RESULT: Amongst the 95 patients, 32 had catheter revision, 24 catheter replacement via the original wound, and 39 catheter replacement via a new mini-laparotomy wound...
December 14, 2017: Nephron
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