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https://www.readbyqxmd.com/read/29338047/amino-acid-substitutions-affecting-aspartic-acid-605-and-valine-606-decrease-the-interaction-strength-between-the-influenza-virus-rna-polymerase-pb2-627-domain-and-the-viral-nucleoprotein
#1
Ho-Pan Hsia, Yin-Hua Yang, Wun-Chung Szeto, Benjamin E Nilsson, Chun-Yeung Lo, Andy Ka-Leung Ng, Ervin Fodor, Pang-Chui Shaw
The influenza virus RNA genome is transcribed and replicated in the context of the viral ribonucleoprotein (vRNP) complex by the viral RNA polymerase. The nucleoprotein (NP) is the structural component of the vRNP providing a scaffold for the viral RNA. In the vRNP as well as during transcription and replication the viral polymerase interacts with NP but it is unclear which parts of the polymerase and NP mediate these interactions. Previously the C-terminal '627' domain (amino acids 538-693) of PB2 was shown to interact with NP...
2018: PloS One
https://www.readbyqxmd.com/read/29335773/effects-of-combining-ergonomic-interventions-and-motor-control-exercises-on-muscle-activity-and-kinematics-in-people-with-work-related-neck-shoulder-pain
#2
Sharon M H Tsang, Billy C L So, Rufina W L Lau, Jie Dai, Grace P Y Szeto
PURPOSE: This study compared the effects of "Ergomotor" intervention and conventional physiotherapy, on influencing the motor control in the neck-shoulder region in people with work-related neck-shoulder pain (WRNSP). METHODS: 101 patients (age range 20-54 years) diagnosed with chronic WRNSP were randomized into control (CO) group (n = 50) and Ergomotor (EM) group (n = 51). Each group received a 12-week intervention. Participants in CO group received treatment for pain relief and general exercises...
January 15, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29301017/urinary-mitochondrial-dna-level-is-an-indicator-of-intra-renal-mitochondrial-depletion-and-renal-scarring-in-diabetic-nephropathy
#3
Pascal Zhongping Wei, Bonnie Ching-Ha Kwan, Kai Ming Chow, Phyllis Mei-Shan Cheng, Cathy Choi-Wan Luk, Philip Kam-Tao Li, Cheuk Chun Szeto
Background: Mitochondrial dysfunction plays an important role in the pathogenesis and progression of diabetic nephropathy (DN). We study the relation between urinary and intra-renal mitochondrial deoxyribonucleic acid (mtDNA) levels and renal dysfunction in DN. Methods: We recruited 92 patients with biopsy-proven DN. Urinary sediment, urinary supernatant and intra-renal mtDNA levels were measured and compared with baseline renal biopsy, kidney scarring and renal function decline in the subsequent 24 months...
December 28, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29278650/synthesis-of-15-n-cholamine-bromide-hydrobromide
#4
Judy Szeto, Remy Lemoine, Rosary Nguyen, Lori L Olson, Mary J Tanga
[15 N]-Cholamine is an isotope tag for metabolomics research, because it possesses two important properties: an NMR active isotope and a permanent charge for MS sensitivity. Here we present a scalable synthesis of [15 N]-cholamine.
December 26, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29274077/increasing-t-type-calcium-channel-activity-by-%C3%AE-adrenergic-stimulation-contributes-to-%C3%AE-adrenergic-regulation-of-heart-rates
#5
Yingxin Li, Xiaoxiao Zhang, Chen Zhang, Xiaoying Zhang, Ying Li, Zhao Qi, Christopher Szeto, Mingxin Tang, Yizhi Peng, Jeffery D Molkentin, Steven R Houser, Mingxing Xie, Xiongwen Chen
OBJECTIVE: Cav3.1 (α1G ) T-type Ca2+ channel (TTCC) is expressed in mouse sinoatrial node cells (SANCs) and atrioventricular nodal (AVN) cells and contributes to heart rate genesis and AV conduction. However, its role in heart rate (HR) regulation and AV conduction acceleration by the β-adrenergic system (SAS) is unclear, which is the topic of this study. METHODS AND RESULTS: L- (ICa-L ) and T-type (ICa-T ) Ca2+ currents were recorded in SANCs from Cav3.1 transgenic (TG) and knockout (KO), and control mice...
December 23, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29250217/atrial-fibrillation-is-associated-with-increased-pacemaker-implantation-rates-in-the-placement-of-aortic-transcatheter-valve-partner-trial
#6
Angelo B Biviano, Tamim Nazif, Jose Dizon, Hasan Garan, Mark Abrams, Jessica Fleitman, Dua Hassan, Samir Kapadia, Vasilis Babaliaros, Ke Xu, Josep Rodes-Cabau, Wilson Y Szeto, William F Fearon, Danny Dvir, Todd Dewey, Mathew Williams, Steven Kindsvater, Michael J Mack, John G Webb, D Craig Miller, Craig R Smith, Martin B Leon, Susheel Kodali
Atrial fibrillation (AF) is associated with worse outcomes in many cardiovascular diseases. There are few data examining pacemaker implantation rates and indications in patients with AF who undergo transcatheter aortic valve replacement (TAVR). To examine the impact of AF on the incidence of and indications for pacemakers in patients undergoing TAVR, we evaluated data of 1723 patients without pre-existing pacemakers who underwent TAVR in the Placement of AoRTic TraNscathetER Valve (PARTNER) trial. Permanent pacemaker implantation rates and indications were compared in groups based on baseline and discharge heart rhythm: sinus rhythm (SR) vs...
June 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29241164/peritoneal-dialysis-catheter-revision-and-replacement-by-nephrologist-for-peritoneal-dialysis-catheter-malfunction
#7
Terry King-Wing Ma, Kai Ming Chow, Bonnie Ching-Ha Kwan, Jack Kit-Chung Ng, Agnes Shin-Man Choy, Vickie Wai-Ki Kwong, Wing-Fai Pang, Chi Bon Leung, Philip Kam-To Li, Cheuk Chun Szeto
BACKGROUND: Catheter malfunction is an important cause of technique failure for peritoneal dialysis (PD) patients, and is commonly managed by surgeons or intervention radiologists. We reviewed our experience in catheter revision or replacement by nephrologists. METHOD: We reviewed the clinical outcome and complication rate of 95 consecutive patients who had PD catheter malfunction, with catheter revision or replacement by nephrologist. RESULT: Amongst the 95 patients, 32 had catheter revision, 24 catheter replacement via the original wound, and 39 catheter replacement via a new mini-laparotomy wound...
December 14, 2017: Nephron
https://www.readbyqxmd.com/read/29216679/the-role-of-extracorporeal-membrane-oxygenator-therapy-in-the-setting-of-type-a-aortic-dissection
#8
Ibrahim Sultan, Andreas Habertheuer, Tyler Wallen, Mary Siki, Wilson Szeto, Joseph E Bavaria, Matthew Williams, Prashanth Vallabhajosyula
BACKGROUND AND AIM: Patients presenting with type A aortic dissection (TAAD) present with a wide clinical spectrum ranging from hemodynamic stability to multiorgan malperfusion with cardiovascular collapse. Extracorporeal membrane oxygenator (ECMO) therapy is increasingly being utilized as salvage therapy in patients with acute cardiopulmonary failure and for post-cardiotomy shock. We sought to determine the utility of ECMO implementation post-TAAD repair. METHODS: The Pennsylvania Health Care Cost Containment Council (PHC4) database, maintained by an independently functioning state agency, was retrospectively reviewed from 2004 to 2014...
December 7, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29197632/crosstalk-between-autophagy-and-oxidative-stress-regulates-proteolysis-in-the-diaphragm-during-mechanical-ventilation
#9
Ashley J Smuder, Kurt J Sollanek, W Bradley Nelson, Kisuk Min, Erin E Talbert, Andreas N Kavazis, Matthew B Hudson, Marco Sandri, Hazel H Szeto, Scott K Powers
Mechanical ventilation (MV) results in the rapid development of ventilator-induced diaphragm dysfunction (VIDD). While the mechanisms responsible for VIDD are not fully understood, recent data reveal that prolonged MV activates autophagy in the diaphragm, which may occur as a result of increased cellular reactive oxygen species (ROS) production. Therefore, we tested the hypothesis that 1) accelerated autophagy is a key contributor to VIDD; and that 2) oxidative stress is required to increase the expression of autophagy genes in the diaphragm...
November 29, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29174665/pro-tobacco-advertisement-exposure-among-african-american-smokers-an-ecological-momentary-assessment-study
#10
Cendrine D Robinson, Christine Muench, Emily Brede, Romano Endrighi, Edwin H Szeto, Joanna R Sells, John P Lammers, Kolawole S Okuyemi, Grant Izmirlian, Andrew J Waters
INTRODUCTION: Many African Americans live in communities with a disproportionately high density of tobacco advertisements compared to Whites. Some research indicates that point-of-sale advertising is associated with impulse purchases of cigarettes and smoking. Ecological Momentary Assessment (EMA) can be used to examine associations between tobacco advertisement exposure and smoking variables in the natural environment. METHODS: Non-treatment seeking African American smokers were given a mobile device for 2weeks (N=56)...
October 24, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29155501/urinary-mrna-and-lupus-disease-flare
#11
REVIEW
Cheuk-Chun Szeto
In the past 20 years, extraction and quantification of mRNA from urinary sediment has emerged as a novel laboratory technique. The potential application of urinary mRNA quantification to the clinical care of patients with SLE has become an active field of research. However, published studies in this area are limited to small-scale ones. mRNA levels of several of cytokine and transcript factor genes have been found to have the potential for the diagnosis or monitoring of disease activity in patients with lupus nephritis...
December 2017: Nephrology
https://www.readbyqxmd.com/read/29153427/does-a-mobile-ecls-program-reduce-mortality-for-patients-transported-for-ecls-therapy-for-severe-acute-respiratory-failure
#12
Jacob T Gutsche, Todd A Miano, William Vernick, Jesse Raiten, Christian Bermudez, Prashant Vallabjoysula, Karianna Milewski, Wilson Szeto, Meghan Lane Fall, Matthew L Williams, Prakash Patel, Mark E Mikkelsen, Cornel Chiu, Harish Ramakrishna, Jeremy Canon, John G Augoustides
OBJECTIVE: To understand if mobile extracorporeal membrane oxygenation reduces patient mortality during and after transport of patients requiring extracorporeal membrane oxygenation for acute respiratory distress syndrome. DESIGN: Retrospective chart review. SETTING: University affiliated tertiary care hospitals. PARTICIPANTS: Seventy-seven patients. INTERVENTIONS: Introduction of a mobile extracorporeal membrane oxygenation (ECMO) program designed to facilitate the implementation of ECMO at outside hospitals in patients too unstable for transport for ECMO...
September 2, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29143378/management-of-coronary-obstruction-following-transcatheter-aortic-valve-replacement
#13
REVIEW
Ibrahim Sultan, Mary Siki, Tyler Wallen, Wilson Szeto, Prashanth Vallabhajosyula
Although occlusion of the coronary arteries during transcatheter aortic valve replacement is rare, the mortality is high. In this review, we discuss the prevention and management of this complication. Occlusion of coronary ostia is a very rare, but serious, complication of transcatheter aortic valve replacement (TAVR). Although reported as only occurring in <1% of TAVR cases, it carries a high risk of fatality, with some series reporting a mortality rate as high as 40%. We present the management of an occluded left coronary artery after a self-expanding TAVR, and review the incidence, prevention, and management of this complication...
November 16, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29136454/immediate-label-free-ex-vivo-evaluation-of-human-brain-tumor-biopsies-with-confocal-reflectance-microscopy
#14
Jennifer M Eschbacher, Joseph F Georges, Evgenii Belykh, Mohammedhassan Izady Yazdanabadi, Nikolay L Martirosyan, Emily Szeto, Catherine Y Seiler, Michael A Mooney, Jessica K Daniels, Katherine Y Goehring, Kendall R Van Keuren-Jensen, Mark C Preul, Stephen W Coons, Shwetal Mehta, Peter Nakaji
Confocal microscopy utilizing fluorescent dyes is widely gaining use in the clinical setting as a diagnostic tool. Reflectance confocal microscopy is a method of visualizing tissue specimens without fluorescent dyes while relying on the natural refractile properties of cellular and subcellular structures. We prospectively evaluated 76 CNS lesions with confocal reflectance microscopy (CRM) to determine cellularity, architecture, and morphological characteristics. A neuropathologist found that all cases showed similar histopathological features when compared to matched hematoxylin and eosin-stained sections...
December 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29133203/expression-and-functional-characterization-of-tachykinin-related-peptides-in-the-blood-feeding-bug-rhodnius-prolixus
#15
A N S Haddad, M S Defferrari, S Hana, S G Szeto, A B Lange
Tachykinins (tachykinin-related peptides, TRPs) are multifunctional neuropeptides that have widespread distribution in the central nervous system (CNS) and in the gastrointestinal tract of many insects, and most have been shown to stimulate contractions of visceral muscles. Invertebrate TRPs carry a characteristic conserved C-terminal pentapeptide (FXGXR-amide) and most of them share some amino acid sequence similarities (approx. 45%) with the vertebrate and mammalian tachykinin family. We have functionally characterized the tachykinins in R...
November 10, 2017: Peptides
https://www.readbyqxmd.com/read/29112771/role-of-mitochondria-and-mitochondria-targeted-agents-in-non-alcoholic-fatty-liver-disease
#16
REVIEW
Thekkuttuparambil Ananthanarayanan Ajith
Mitochondria play a pivotal role in the fatty acid oxidation and have been found to be affected early during the macrovesicular fat accumulation in the hepatocytes. The fatty infiltration is the primary cause of oxidative stress and inflammation in the non-alcoholic fatty liver disease (NAFLD), which can lead to the peroxidation of phospholipids, such as cardiolipin. Oxidative stress-induced damage to mitochondrial DNA can result in the impairment of oxidative phosphorylation and further increases the generation of reactive oxygen species...
November 7, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29090335/the-prevalence-of-musculoskeletal-symptoms-in-the-construction-industry-a-systematic-review-and-meta-analysis
#17
Waleed Umer, Maxwell F Antwi-Afari, Heng Li, Grace P Y Szeto, Arnold Y L Wong
PURPOSE: Although individual studies have reported high prevalence of musculoskeletal symptoms (MSS) among construction workers, no systematic review has summarized their prevalence rates. Accordingly, this systematic review/meta-analysis aimed to synthesize MSS prevalence in different construction trades, gender and age groups, which may help develop specific ergonomic interventions. METHODS: Nine databases were searched for articles related to the research objective...
October 31, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29073597/treatment-of-enterococcal-peritonitis-in-peritoneal-dialysis-patients-by-oral-amoxicillin-or-intra-peritoneal-vancomcyin-a-retrospective-study
#18
Cheuk Chun Szeto, Jack Kit-Chung Ng, Kai Ming Chow, Bonnie Ching-Ha Kwan, Vickie Wai-Ki Kwong, Man-Ching Law, Chi Bon Leung, Philip Kam-To Li
BACKGROUND/AIMS: Enterococcal peritonitis in peritoneal dialysis (PD) patients is associated with a high complication rate. The optimal treatment regimen of PD-related enterococcal peritonitis is controversial. The latest international guideline recommends intra-peritoneal (IP) vancomycin. Although ampicillin is often effective for systemic enterococcal infections, they have little in vitro activity when added to common PD solutions. Since oral amoxicillin achieves therapeutic drug level in the peritoneal cavity, we explore the efficacy of oral amoxicillin for enterococcal peritonitis...
October 27, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29065174/glucagon-like-receptor-1-glucagon-dual-agonist-acutely-enhanced-hepatic-lipid-clearance-and-suppressed-de-novo-lipogenesis-in-mice
#19
Vijay R More, Julie Lao, David G McLaren, Anne-Marie Cumiskey, Beth Ann Murphy, Ying Chen, Stephen Previs, Steven Stout, Rajesh Patel, Santhosh Satapati, Wenyu Li, Edward Kowalik, Daphne Szeto, Andrea Nawrocki, Alessandro Pocai, Liangsu Wang, Paul Carrington
Lipid lowering properties of glucagon have been reported. Blocking glucagon signaling leads to rise in plasma LDL levels. Here, we demonstrate the lipid lowering effects of acute dosing with Glp1r/Gcgr dual agonist (DualAG). All the experiments were performed in 25 week-old male diet-induced (60% kCal fat) obese mice. After 2 hrs of fasting, mice were injected subcutaneously with vehicle, liraglutide (25nmol/kg) and DualAG (25nmol/kg). De novo cholesterol and palmitate synthesis was measured by deuterium incorporation method using D2O...
2017: PloS One
https://www.readbyqxmd.com/read/29053717/gpr40-partial-agonists-and-agopams-differentiating-effects-on-glucose-and-hormonal-secretions-in-the-rodent
#20
Michele J Pachanski, Melissa E Kirkland, Daniel T Kosinski, Joel Mane, Boonlert Cheewatrakoolpong, Jiyan Xue, Daphne Szeto, Gail Forrest, Corin Miller, Michelle Bunzel, Christopher W Plummer, Harry R Chobanian, Michael W Miller, Sarah Souza, Brande S Thomas-Fowlkes, Aimie M Ogawa, Adam B Weinglass, Jerry Di Salvo, Xiaoyan Li, Yue Feng, Daniel A Tatosian, Andrew D Howard, Steven L Colletti, Maria E Trujillo
GPR40 agonists are effective antidiabetic agents believed to lower glucose through direct effects on the beta cell to increase glucose stimulated insulin secretion. However, not all GPR40 agonists are the same. Partial agonists lower glucose through direct effects on the pancreas, whereas GPR40 AgoPAMs may incorporate additional therapeutic effects through increases in insulinotrophic incretins secreted by the gut. Here we describe how GPR40 AgoPAMs stimulate both insulin and incretin secretion in vivo over time in diabetic GK rats...
2017: PloS One
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