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Yoshikazu Suzuki

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https://www.readbyqxmd.com/read/28439027/biochemical-and-structural-characterization-of-oxygen-sensitive-2-thiouridine-synthesis-catalyzed-by-an-iron-sulfur-protein-ttua
#1
Minghao Chen, Shin-Ichi Asai, Shun Narai, Shusuke Nambu, Naoki Omura, Yuriko Sakaguchi, Tsutomu Suzuki, Masao Ikeda-Saito, Kimitsuna Watanabe, Min Yao, Naoki Shigi, Yoshikazu Tanaka
Two-thiouridine (s(2)U) at position 54 of transfer RNA (tRNA) is a posttranscriptional modification that enables thermophilic bacteria to survive in high-temperature environments. s(2)U is produced by the combined action of two proteins, 2-thiouridine synthetase TtuA and 2-thiouridine synthesis sulfur carrier protein TtuB, which act as a sulfur (S) transfer enzyme and a ubiquitin-like S donor, respectively. Despite the accumulation of biochemical data in vivo, the enzymatic activity by TtuA/TtuB has rarely been observed in vitro, which has hindered examination of the molecular mechanism of S transfer...
April 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28410772/recovery-of-quantum-efficiency-in-spin-polarized-photocathodes-by-atomic-hydrogen-cleaning
#2
Xiuguang Jin, Masao Suzuki, Tsuneo Yasue, Takanori Koshikawa, Yoshikazu Takeda
We demonstrate a new method of cleaning superlattice (SL) photocathodes using atomic hydrogen that allows an increased number of repeat activations. GaAs/GaAsP SL photocathodes were activated with either conventional heat cleaning or atomic hydrogen cleaning. Repeated heat cleaning was found to gradually lower the quantum efficiency (QE) of the photocathodes, while a relatively constant QE was maintained over repeated atomic hydrogen cleaning. These results show that atomic hydrogen cleaning allows a greater number of photocathode cleanings without a loss of performance...
March 30, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28409862/synthesis-and-properties-of-salicylaldehydes-fine-tuned-by-modular-assembly-using-plug-and-socket-type-extendibility
#3
Hirohiko Houjou, Yoshikazu Suzuki, Qian-Wen Shen, Isao Yoshikawa, Toshiki Mutai
We prepared a salicylaldehyde derivative bearing four pyridine arms, 3,5-bis(N,N-bis(2-pyridylmethyl)aminomethyl)-2,4-dihydroxybenzaldehyde (Hbpsal) as a "socket", and used it to derive a series of zinc complexes with various extra anions "plugged" into their vacant site. The crystal structure and 1H NMR spectra were noticeably influenced by the extra anions, allowing fine-tuning of the properties by "plug-and-socket" type modification. Similar to unsubstituted salicylaldehyde, the zinc complexes reacted with primary amines to afford Schiff base compounds...
April 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28397000/efficacy-of-post-nephroureterectomy-cisplatin-based-adjuvant-chemotherapy-for-locally-advanced-upper-tract-urothelial-carcinoma-a-multi-institutional-retrospective-study
#4
Tohru Nakagawa, Yoshimitsu Komemushi, Taketo Kawai, Masafumi Otsuka, Jimpei Miyakawa, Yukari Uemura, Atsushi Kanatani, Satoru Taguchi, Akihiro Naito, Motofumi Suzuki, Hiroaki Nishimatsu, Yoshikazu Hirano, Yoshinori Tanaka, Akihiko Matsumoto, Hideyo Miyazaki, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, Yasuhiko Igawa, Yukio Homma
PURPOSE: To evaluate the efficacy of adjuvant systemic chemotherapy for locally advanced (pT3-4pN0/xM0) upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: We retrospectively reviewed the medical records of 109 patients with pT3-4pN0/xM0 UTUC who had undergone radical nephroureterectomy between 1996 and 2013 at our four institutions. The patients were divided into two groups: those who received adjuvant chemotherapy (AC group) and those who did not (surgery-alone: SA group)...
April 10, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28386914/laparoscopy-assisted-full-thickness-resection-of-the-duodenum-for-patients-with-gastrointestinal-stromal-tumor-with-ulceration
#5
Nobutsugu Abe, Yoshikazu Hashimoto, Hirohisa Takeuchi, Atsuko Ohki, Gen Nagao, Yutaka Suzuki, Tadahiko Masaki, Toshiyuki Mori, Masanori Sugiyama
INTRODUCTION: Gastrointestinal stromal tumor (GIST) with ulceration may potentially disseminate into the peritoneal cavity after laparoscopic local wedge resection (full-thickness resection) when the intestinal wall is opened under the aeroperitoneum. To prevent this intraoperative tumor seeding, we developed laparoscopy-assisted full-thickness resection (LAFTR) of the duodenum for GIST with ulceration. Here, we present the preliminary results of LAFTR. METHODS: Three patients with duodenal GIST with ulceration underwent LAFTR...
April 7, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28367884/prevalence-of-diarrheagenic-escherichia-coli-in-foods-and-fecal-specimens-obtained-from-cattle-pigs-chickens-asymptomatic-carriers-and-patients-in-osaka-and-hyogo-japan
#6
Lili Wang, Shaobo Zhang, Dongming Zheng, Sami Fujihara, Akiyo Wakabayashi, Kazuyuki Okahata, Masakazu Suzuki, Atsunori Saeki, Hiromi Nakamura, Yukiko Hara-Kudo, Eriko Kage-Nakadai, Yoshikazu Nishikawa
The source and routes of diarrheagenic Escherichia coli (DEC) remain poorly clarified. To investigate the involvement of domestic animals in the dissemination of DEC, the prevalence of DEC among foods and fecal specimens of cattle, pigs, chickens, healthy carriers, and patients in Osaka and Hyogo, Japan, was investigated using a multiplex real-time PCR assay. The most prevalent virulence genes were astA and eae, with prevalences of 46.8% and 27.4%, respectively. stx1 (26.6%) and stx2 (45.9%) were prevalent in cattle feces, and est (8...
March 28, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28358967/acute-bilateral-photoreceptor-degeneration-in-an-infant-after-vaccination-against-measles-and-rubella
#7
Kazuki Kuniyoshi, Yoshikazu Hatsukawai, Sadami Kimura, Takahiro Fujino, Hiroshi Ohguro, Rie Nakai, Kenta Sunami, So-Ichiro Mishima, Tomoko Sato, Shunji Kusaka, Yasuhiro Suzuki, Yoshikazu Shimomura
Importance: Ocular inflammation is occasionally observed after vaccinations, and most of them resolve without permanent visual disturbances. However, there are some rare cases of severe ocular complications following vaccinations. Objective: To report the findings in an infant boy who developed an acute loss of vision bilaterally after Haemophilus influenzae type b, Pneumococcal conjugate vaccination, and measles and rubella vaccination. His vision did not recover...
March 30, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28330887/usefulness-of-two-aspergillus-pcr-assays-and-aspergillus-galactomannan-and-%C3%AE-d-glucan-testing-of-bronchoalveolar-lavage-fluid-for-diagnosis-of-chronic-pulmonary-aspergillosis
#8
Naohisa Urabe, Susumu Sakamoto, Go Sano, Junko Suzuki, Akira Hebisawa, Yasuhiko Nakamura, Kazuya Koyama, Yoshikazu Ishii, Kazuhiro Tateda, Sakae Homma
We evaluated the usefulness of an Aspergillus galactomannan (GM) test, a β-D-glucan (βDG) test, and two different Aspergillus polymerase chain reaction (PCR) assays of bronchoalveolar lavage fluid (BALF) samples for diagnosis of chronic pulmonary aspergillosis (CPA). BALF samples from 28 patients with and 120 patients without CPA were collected. We calculated the sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio for each test individually and in combination with other tests...
March 22, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28296195/evaluation-of-the-infection-risk-in-dialysis-and-chronic-kidney-disease-patients-using-an-atp-monitoring-assay
#9
Junichi Kusano, Rei Kato, Hiroto Matsuda, Yoshikazu Hara, Yoshiaki Fujii, Shinya Suzuki, Masao Sekiyama, Eiki Ando, Kentaro Sugiyama, Toshihiko Hirano
The ATP monitoring assay is a useful biomarker for risk monitoring to detect infection and rejection episodes in transplant recipients. Hemodialysis patients have a higher rate of infectious mortality. Infections in hemodialysis patients are mainly caused by venous catheters, uremia, malnutrition and inflammation. However, the risk of infection episodes has not been evaluated using a lymphocyte ATP monitoring assay in hemodialysis and chronic kidney disease (CKD) patients. We measured the ATP amounts in the peripheral CD4+ cells of CKD (N = 85) and dialysis patients (N = 17) using an "Immuknow" assay kit...
March 13, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28282247/effect-of-tenofovir-disoproxil-fumarate-on-incidence-of-chronic-kidney-disease-and-rate-of-estimated-glomerular-filtration-rate-decrement-in-hiv-1-infected-treatment-na%C3%A3-ve-asian-patients-results-from-12-year-observational-cohort
#10
Soichiro Suzuki, Takeshi Nishijima, Yohei Kawasaki, Takuma Kurosawa, Yoshikazu Mutoh, Yoshimi Kikuchi, Hiroyuki Gatanaga, Shinichi Oka
Little evidence is available for the incidence of chronic kidney disease (CKD) and rate of estimated glomerular filtration rate (eGFR) decrement among Asians with low body weight who are susceptible to tenofovir disoproxil fumarate (TDF) nephrotoxicity. In this 12-year observational cohort in Tokyo, we examined 1383 treatment-naïve HIV-1-infected Asians [720 started TDF-containing (TDF group) and 663 started non-TDF-containing (control) combination antiretroviral therapy (cART)]. The CKD incidence was calculated, and the effect of TDF use on CKD development was estimated using logistic regression...
March 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28269999/baseline-mri-bone-erosion-predicts-the-subsequent-radiographic-progression-in-early-rheumatoid-arthritis-patients-who-achieved-sustained-good-clinical-response
#11
Mami Tamai, Kazuhiko Arima, Yoshikazu Nakashima, Junko Kita, Masataka Umeda, Shoichi Fukui, Ayako Nishino, Takahisa Suzuki, Yoshiro Horai, Akitomo Okada, Tomohiro Koga, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Satoshi Yamasaki, Hideki Nakamura, Tomoki Origuchi, Kiyoshi Aoyagi, Masataka Uetani, Katsumi Eguchi, Atsushi Kawakami
OBJECTIVE: To examine whether magnetic resonance imaging (MRI) findings at baseline predict radiographic progression in early-stage rheumatoid arthritis (RA) patients who have achieved sustained good clinical response. METHODS: This is a sub-analysis from the one-year observational study of Nagasaki University Early Arthritis Cohort. Definition of 'good clinical response' was a decrement of disease activity score (DAS) 28 ≧ 1.2 at three months with achievement of DAS28 remission through 6-12 months...
March 8, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28249026/development-of-ghrelin-resistance-in-a-cancer-cachexia-rat-model-using-human-gastric-cancer-derived-85as2-cells-and-the-palliative-effects-of-the-kampo-medicine-rikkunshito-on-the-model
#12
Kiyoshi Terawaki, Yohei Kashiwase, Yumi Sawada, Hirofumi Hashimoto, Mitsuhiro Yoshimura, Katsuya Ohbuchi, Yuka Sudo, Masami Suzuki, Kanako Miyano, Seiji Shiraishi, Yoshikazu Higami, Kazuyoshi Yanagihara, Tomohisa Hattori, Yoshio Kase, Yoichi Ueta, Yasuhito Uezono
Cancer cachexia (CC) is a multifactorial disease characterized by decreased food intake and loss of body weight due to reduced musculature with or without loss of fat mass. Patients with gastric cancer have a high incidence of cachexia. We previously established a novel CC rat model induced by human gastric cancer-derived 85As2 cells in order to examine the pathophysiology of CC and identify potential therapeutics. In patients with CC, anorexia is often observed, despite elevation of ghrelin, suggesting that ghrelin resistance may develop in these patients...
2017: PloS One
https://www.readbyqxmd.com/read/28240558/the-causal-relationship-between-dna-damage-induction-in-bovine-lymphocytes-and-the-fukushima-nuclear-power-plant-accident
#13
Asako J Nakamura, Masatoshi Suzuki, Christophe E Redon, Yoshikazu Kuwahara, Hideaki Yamashiro, Yasuyuki Abe, Shintaro Takahashi, Tomokazu Fukuda, Emiko Isogai, William M Bonner, Manabu Fukumoto
The Fukushima Daiichi Nuclear Power Plant (FNPP) accident, the largest nuclear incident since the 1986 Chernobyl disaster, occurred when the plant was hit by a tsunami triggered by the Great East Japan Earthquake on March 11, 2011. The subsequent uncontrolled release of radioactive substances resulted in massive evacuations in a 20-km zone. To better understand the biological consequences of the FNPP accident, we have been measuring DNA damage levels in cattle in the evacuation zone. DNA damage was evaluated by assessing the levels of DNA double-strand breaks in peripheral blood lymphocytes by immunocytofluorescence-based quantification of γ-H2AX foci...
February 27, 2017: Radiation Research
https://www.readbyqxmd.com/read/28238783/visualization-of-glucagon-secretion-from-pancreatic-%C3%AE-cells-by-bioluminescence-video-microscopy-identification-of-secretion-sites-in-the-intercellular-contact-regions
#14
Satoru Yokawa, Takahiro Suzuki, Satoshi Inouye, Yoshikazu Inoh, Ryo Suzuki, Takao Kanamori, Tadahide Furuno, Naohide Hirashima
We have firstly visualized glucagon secretion using a method of video-rate bioluminescence imaging. The fusion protein of proglucagon and Gaussia luciferase (PGCG-GLase) was used as a reporter to detect glucagon secretion and was efficiently expressed in mouse pancreatic α cells (αTC1.6) using a preferred human codon-optimized gene. In the culture medium of the cells expressing PGCG-GLase, luminescence activity determined with a luminometer was increased with low glucose stimulation and KCl-induced depolarization, as observed for glucagon secretion...
April 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28225296/development-and-validation-of-an-lc-ms-ms-method-for-simultaneously-determining-doxapram-and-keto-doxapram-in-human-serum
#15
Yuki Suzuki, Noboru Kamada, Hitoshi Ohno, Yoshikazu Abe, Takuro Endo, Mamoru Kobayashi
AIM: Doxapram, a respiratory stimulant, is used to treat apnea. A reliable method of determining doxapram in blood is required for monitoring purposes. RESULTS: Doxapram, keto-doxapram (active metabolite) and propranolol (internal standard) were extracted from human serum by protein precipitation and plate filtration. Molecular ions were generated by electrospray ionization in positive ion mode, and the ions were analyzed using a triple-quadrupole mass spectrometer...
March 2017: Bioanalysis
https://www.readbyqxmd.com/read/28180312/restriction-glycosylases-involvement-of-endonuclease-activities-in-the-restriction-process
#16
Yingbiao Zhang, Tomoyuki Matsuzaka, Hirokazu Yano, Yoshikazu Furuta, Toshiaki Nakano, Ken Ishikawa, Masaki Fukuyo, Noriko Takahashi, Yutaka Suzuki, Sumio Sugano, Hiroshi Ide, Ichizo Kobayashi
No abstract text is available yet for this article.
February 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28157481/a-case-of-mycobacterium-abscessus-subsp-massiliense-lung-disease-complicated-by-lipoid-pneumonia
#17
Takehiko Kobayashi, Kazunari Tsuyuguchi, Shiomi Yoshida, Yu Kurahara, Taisuke Tsuji, Keiko Nakao, Yumiko Sasaki, Seiji Hayashi, Yoshikazu Inoue, Katsuhiro Suzuki
No abstract text is available yet for this article.
January 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28142030/rationale-design-and-profile-of-the-three-prefecture-cohort-in-japan-a-15-year-follow-up
#18
Junya Sado, Tetsuhisa Kitamura, Yuri Kitamura, Ling Zha, Rong Liu, Tomotaka Sobue, Yoshikazu Nishino, Hideo Tanaka, Tomio Nakayama, Ichiro Tsuji, Hidemi Ito, Takaichiro Suzuki, Kota Katanoda, Suketami Tominaga
BACKGROUND: We reutilized the existing Three-Prefecture Cohort to evaluate the relationship between lifestyle factors and the incidence or mortality from non-communicable diseases. METHODS: This study was a prospective population-based observation conducted from the 1980s to 2000 in three prefectures (Miyagi, Aichi, and Osaka) in Japan. The study subjects were residents aged ≥40 years who received a questionnaire. The follow-up period was 15 years from the baseline survey in each study area...
April 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28117940/peripheral-blood-gene-expression-changes-associated-with-primary-graft-dysfunction-after-lung-transplantation
#19
J M Diamond, E Cantu, M K Porteous, Y Suzuki, K C Meyer, D J Lederer, R K Milewski, S Arcasoy, F D'Ovidio, M Bacchetta, J R Sonett, G Singh, J Costa, J W Tobias, H Rodriguez, V M Van Deerlin, K M Olthoff, A Shaked, B-L Chang, J D Christie
Recipient responses to primary graft dysfunction (PGD) after lung transplantation may have important implications to the fate of the allograft. We therefore evaluated longitudinal differences in peripheral blood gene expression in subjects with PGD. RNA expression was measured throughout the first transplant year in 106 subjects enrolled in the Clinical Trials in Organ Transplantation-03 study using a panel of 100 hypothesis-driven genes. PGD was defined as grade 3 in the first 72 posttransplant hours. Eighteen genes were differentially expressed over the first year based on PGD development, with significant representation from innate and adaptive immunity genes, with most differences identified very early after transplant...
January 24, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28110856/nomogram-for-predicting-survival-of-postcystectomy-recurrent-urothelial-carcinoma-of-the-bladder
#20
Tohru Nakagawa, Satoru Taguchi, Yukari Uemura, Atsushi Kanatani, Masaomi Ikeda, Akihiko Matsumoto, Kanae Yoshida, Taketo Kawai, Masayoshi Nagata, Daisuke Yamada, Yoshimitsu Komemushi, Motofumi Suzuki, Yutaka Enomoto, Hiroaki Nishimatsu, Akira Ishikawa, Yasushi Nagase, Yasushi Kondo, Yoshinori Tanaka, Toshikazu Okaneya, Yoshikazu Hirano, Mitsuru Shinohara, Hideyo Miyazaki, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, Yasuhiko Igawa, Yukio Homma
PURPOSE: We aimed to identify prognostic clinicopathological factors and to create a nomogram able to predict overall survival (OS) in recurrent urothelial carcinoma of the bladder (UCB) after radical cystectomy (RC). MATERIALS AND METHODS: Among 1,087 patients with UCB who had undergone RC at our 11 institutions between 1990 and 2010, 306 patients who subsequently developed distant metastasis or local recurrence or both were identified. Clinical data were collected with medical record review...
January 16, 2017: Urologic Oncology
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