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Yoshikazu Suzuki

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https://www.readbyqxmd.com/read/28704456/atg4-plays-an-important-role-in-efficient-expansion-of-autophagic-isolation-membranes-by-cleaving-lipidated-atg8-in-saccharomyces-cerevisiae
#1
Eri Hirata, Yoshikazu Ohya, Kuninori Suzuki
Autophagy, an intracellular degradation system, is highly conserved among eukaryotes from yeast to mammalian cells. In the yeast Saccharomyces cerevisiae, most Atg (autophagy-related) proteins, which are essential for autophagosome formation, are recruited to a restricted region close to the vacuole, termed the vacuole-isolation membrane contact site (VICS), upon induction of autophagy. Subsequently, the isolation membrane (IM) expands and sequesters cytoplasmic materials to become a closed autophagosome. In S...
2017: PloS One
https://www.readbyqxmd.com/read/28697865/revision-total-hip-arthroplasty-using-a-cementless-cup-supporter-and-iliac-autograft-a-minimum-of-15-year-follow-up
#2
Kensuke Yoshino, Tadashi Tsukeoka, Yoshikazu Tsuneizumi, Tae Hyun Lee, Junichi Nakamura, Masahiko Suzuki, Seiji Ohtori
BACKGROUND: Bone deficiency in revision total hip arthroplasty is a surgical challenge. The Murata-Chiba cup supporter (MC support ring) is an acetabular component supporter for a cementless porous-coated cup. The purpose of this study is to examine the clinical and radiographic outcomes of reconstruction of acetabular bone deficiency using iliac autografts supported by an MC support ring in a revision setting with minimum 15-year follow-up. METHODS: Fifty-nine consecutive revision total hip arthroplasties (57 patients) using the MC support ring were followed for a minimum of 15 years...
June 20, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28687875/oncologic-outcome-of-metastasectomy-for-urothelial-carcinoma-who-is-the-best-candidate
#3
Tohru Nakagawa, Satoru Taguchi, Atsushi Kanatani, Taketo Kawai, Masaomi Ikeda, Shinji Urakami, Akihiko Matsumoto, Yoshimitsu Komemushi, Jimpei Miyakawa, Daisuke Yamada, Motofumi Suzuki, Yutaka Enomoto, Hiroaki Nishimatsu, Yasushi Kondo, Yasushi Nagase, Yoshikazu Hirano, Toshikazu Okaneya, Yoshinori Tanaka, Hideyo Miyazaki, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, Yasuhiko Igawa, Yukio Homma
BACKGROUND: Resection of metastatic lesions (metastasectomy) is performed for highly selected patients with metastatic urothelial carcinoma (mUC). This study aimed to identify the clinicopathologic factors associated with oncologic outcome for patients who underwent metastasectomy for mUC. METHODS: This analysis included 37 UC patients who underwent metastasectomy with curative intent at nine Japanese hospitals. The primary end point was cancer-specific survival...
July 7, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28676645/kif5a-transports-collagen-vesicles-of-myofibroblasts-during-pleural-fibrosis
#4
Hirotoshi Kamata, Yoshikazu Tsukasaki, Tsuyoshi Sakai, Reiko Ikebe, Julia Wang, Ann Jeffers, Jake Boren, Shuzi Owens, Takahiro Suzuki, Masaaki Higashihara, Steven Idell, Torry A Tucker, Mitsuo Ikebe
Fibrosis involves the production of extracellular matrix proteins in tissues and is often preceded by injury or trauma. In pleural fibrosis excess collagen deposition results in pleural thickening, increased stiffness and impaired lung function. Myofibroblasts are responsible for increased collagen deposition, however the molecular mechanism of transportation of procollagen containing vesicles for secretion is unknown. Here, we studied the role of kinesin on collagen-1 (Col-1) containing vesicle transportation in human pleural mesothelial cells (HPMCs)...
July 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28638143/siblings-with-optic-neuropathy-and-rtn4ip1-mutation
#5
Nobuhiko Okamoto, Fuyuki Miya, Yoshikazu Hatsukawa, Yasuhiro Suzuki, Kazumi Kawato, Yuto Yamamoto, Tatsuhiko Tsunoda, Mitsuhiro Kato, Shinji Saitoh, Mami Yamasaki, Yonehiro Kanemura, Kenjiro Kosaki
Inherited optic neuropathies (IONs) are neurodegenerative disorders affecting the optic nerve and the nervous system. Dominant and recessive IONs are known. Many of the dominant IONs are caused by mutations of OPA1. Autosomal-recessive IONs are rare. OPA10 is an autosomal-recessive ION due to mutations in RTN4IP1. Patients with RTN4IP1 mutations show extraocular manifestations. We report brothers with optic neuropathy who had novel mutations in the RTN4IP1 gene. This is the first report of Japanese patients with OPA10...
June 22, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28628221/influence-of-radiofrequency-electromagnetic-waves-from-3rd-generation-cellular-phones-on-fertilization-and-embryo-development-in-mice
#6
Satoshi Suzuki, Miho Okutsu, Ryota Suganuma, Hiromi Komiya, Setsu Nakatani-Enomoto, Shunsuke Kobayashi, Yoshikazu Ugawa, Hiroyuki Tateno, Keiya Fujimori
The purpose of this study was to evaluate the effects of 3rd-generation (3G) cellular phone radiofrequency-electromagnetic wave (RF-EMW) exposure on fertilization and embryogenesis in mice. Oocytes and spermatozoa were exposed to 3G cellular phone RF-EMWs, 1.95 GHz wideband code division multiple access, at a specific absorption rate of 2 mW/g for 60 min, or to sham exposure. After RF-EMW exposure, in vitro fertilization and intracytoplasmic sperm injection were performed. Rates of fertilization, embryogenesis (8-cell embryo, blastocyst), and chromosome aberration were compared between the combined spermatozoa and oocyte groups: both exposed, both non-exposed, one exposed, and the other non-exposed...
June 19, 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/28613399/immunosuppressive-efficacy-of-tetrandrine-combined-with-methylprednisolone-against-mitogen-activated-peripheral-blood-mononuclear-cells-of-hemodialysis-patients
#7
Wencheng Xu, Kehan Meng, Junichi Kusano, Hiroto Matsuda, Yoshikazu Hara, Yoshiaki Fujii, Shinya Suzuki, Eiki Ando, Xiaoqin Wang, Yuanchao Tu, Sachiko Tanaka, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano
Immunosuppressive therapy for prevention of acute rejection episode occasionally causes serious adverse effects, and thus it is important to develop new therapeutic approach for renal transplant recipients. This study evaluated the immunosuppressive pharmacodynamics of tetrandrine (TET) and/or methylprednisolone (MP) in hemodialysis patients in vitro by using the peripheral blood mononuclear cells (PBMCs) isolated from whole blood of hemodialysis patients. The median (range) of MP IC50 values against the proliferation of patients PBMCs was 7...
June 14, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28567176/combinatorial-screening-of-halide-perovskite-thin-films-and-solar-cells-by-mask-defined-ir-laser-molecular-beam-epitaxy
#8
Kazuhiro Kawashima, Yuji Okamoto, Orazmuhammet Annayev, Nobuo Toyokura, Ryota Takahashi, Mikk Lippmaa, Kenji Itaka, Yoshikazu Suzuki, Nobuyuki Matsuki, Hideomi Koinuma
As an extension of combinatorial molecular layer epitaxy via ablation of perovskite oxides by a pulsed excimer laser, we have developed a laser molecular beam epitaxy (MBE) system for parallel integration of nano-scaled thin films of organic-inorganic hybrid materials. A pulsed infrared (IR) semiconductor laser was adopted for thermal evaporation of organic halide (A-site: CH3NH3I) and inorganic halide (B-site: PbI2) powder targets to deposit repeated A/B bilayer films where the thickness of each layer was controlled on molecular layer scale by programming the evaporation IR laser pulse number, length, or power...
2017: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/28566553/systematic-analysis-of-ca-2-homoeostasis-in-saccharomyces-cerevisiae-based-on-chemical-genetic-interaction-profiles
#9
Farzan Ghanegolmohammadi, Mitsumori Yoshida, Shinsuke Ohnuki, Yuko Sukegawa, Hiroki Okada, Keisuke Obara, Akio Kihara, Kuninori Suzuki, Tetsuya Kojima, Nozomu Yachie, Dai Hirata, Yoshikazu Ohya
We investigated the global landscape of Ca(2+) homeostasis in the budding yeast based on high-dimensional chemical-genetic interaction profiles. The morphological responses of 62 Ca(2+)-sensitive (cls) mutants were quantitatively analyzed with the image processing program CalMorph following exposure to a high concentration of Ca(2+) After a generalized linear model was applied, an analysis of covariance model was used to detect significant Ca(2+)-cls interactions. We found that high-dimensional, morphological Ca(2+)-cls interactions were mixed with positive (86%) and negative (14%) chemical-genetic interactions, while one-dimensional fitness Ca(2+)-cls interactions were all negative in principle...
May 31, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28439027/biochemical-and-structural-characterization-of-oxygen-sensitive-2-thiouridine-synthesis-catalyzed-by-an-iron-sulfur-protein-ttua
#10
Minghao Chen, Shin-Ichi Asai, Shun Narai, Shusuke Nambu, Naoki Omura, Yuriko Sakaguchi, Tsutomu Suzuki, Masao Ikeda-Saito, Kimitsuna Watanabe, Min Yao, Naoki Shigi, Yoshikazu Tanaka
Two-thiouridine (s(2)U) at position 54 of transfer RNA (tRNA) is a posttranscriptional modification that enables thermophilic bacteria to survive in high-temperature environments. s(2)U is produced by the combined action of two proteins, 2-thiouridine synthetase TtuA and 2-thiouridine synthesis sulfur carrier protein TtuB, which act as a sulfur (S) transfer enzyme and a ubiquitin-like S donor, respectively. Despite the accumulation of biochemical data in vivo, the enzymatic activity by TtuA/TtuB has rarely been observed in vitro, which has hindered examination of the molecular mechanism of S transfer...
May 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28410772/recovery-of-quantum-efficiency-in-spin-polarized-photocathodes-by-atomic-hydrogen-cleaning
#11
Xiuguang Jin, Masao Suzuki, Tsuneo Yasue, Takanori Koshikawa, Yoshikazu Takeda
We demonstrate a new method of cleaning superlattice (SL) photocathodes using atomic hydrogen that allows an increased number of repeat activations. GaAs/GaAsP SL photocathodes were activated with either conventional heat cleaning or atomic hydrogen cleaning. Repeated heat cleaning was found to gradually lower the quantum efficiency (QE) of the photocathodes, while a relatively constant QE was maintained over repeated atomic hydrogen cleaning. These results show that atomic hydrogen cleaning allows a greater number of photocathode cleanings without a loss of performance...
March 30, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28409862/synthesis-and-properties-of-salicylaldehydes-fine-tuned-by-modular-assembly-using-plug-and-socket-type-extendibility
#12
Hirohiko Houjou, Yoshikazu Suzuki, Qian-Wen Shen, Isao Yoshikawa, Toshiki Mutai
A salicylaldehyde derivative bearing four pyridine arms, 3,5-bis(N,N-bis(2-pyridylmethyl)aminomethyl)-2,4-dihydroxybenzaldehyde (Hbpsal) as a "socket", was prepared and used to derive a series of zinc complexes with various extra anions "plugged" into their vacant site. The crystal structure and (1) H NMR spectra were noticeably influenced by the extra anions, allowing fine-tuning of the properties by "plug-and-socket"-type modification. Similar to unsubstituted salicylaldehyde, the zinc complexes reacted with primary amines to afford Schiff-base compounds...
April 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28397000/efficacy-of-post-nephroureterectomy-cisplatin-based-adjuvant-chemotherapy-for-locally-advanced-upper-tract-urothelial-carcinoma-a-multi-institutional-retrospective-study
#13
Tohru Nakagawa, Yoshimitsu Komemushi, Taketo Kawai, Masafumi Otsuka, Jimpei Miyakawa, Yukari Uemura, Atsushi Kanatani, Satoru Taguchi, Akihiro Naito, Motofumi Suzuki, Hiroaki Nishimatsu, Yoshikazu Hirano, Yoshinori Tanaka, Akihiko Matsumoto, Hideyo Miyazaki, Tetsuya Fujimura, Hiroshi Fukuhara, Haruki Kume, Yasuhiko Igawa, Yukio Homma
PURPOSE: To evaluate the efficacy of adjuvant systemic chemotherapy for locally advanced (pT3-4pN0/xM0) upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: We retrospectively reviewed the medical records of 109 patients with pT3-4pN0/xM0 UTUC who had undergone radical nephroureterectomy between 1996 and 2013 at our four institutions. The patients were divided into two groups: those who received adjuvant chemotherapy (AC group) and those who did not (surgery-alone: SA group)...
April 10, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28386914/laparoscopy-assisted-full-thickness-resection-of-the-duodenum-for-patients-with-gastrointestinal-stromal-tumor-with-ulceration
#14
Nobutsugu Abe, Yoshikazu Hashimoto, Hirohisa Takeuchi, Atsuko Ohki, Gen Nagao, Yutaka Suzuki, Tadahiko Masaki, Toshiyuki Mori, Masanori Sugiyama
INTRODUCTION: Gastrointestinal stromal tumor (GIST) with ulceration may potentially disseminate into the peritoneal cavity after laparoscopic local wedge resection (full-thickness resection) when the intestinal wall is opened under the aeroperitoneum. To prevent this intraoperative tumor seeding, we developed laparoscopy-assisted full-thickness resection (LAFTR) of the duodenum for GIST with ulceration. Here, we present the preliminary results of LAFTR. METHODS: Three patients with duodenal GIST with ulceration underwent LAFTR...
April 7, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28367884/prevalence-of-diarrheagenic-escherichia-coli-in-foods-and-fecal-specimens-obtained-from-cattle-pigs-chickens-asymptomatic-carriers-and-patients-in-osaka-and-hyogo-japan
#15
Lili Wang, Shaobo Zhang, Dongming Zheng, Sami Fujihara, Akiyo Wakabayashi, Kazuyuki Okahata, Masakazu Suzuki, Atsunori Saeki, Hiromi Nakamura, Yukiko Hara-Kudo, Eriko Kage-Nakadai, Yoshikazu Nishikawa
The source and routes of diarrheagenic Escherichia coli (DEC) remain poorly clarified. To investigate the involvement of domestic animals in the dissemination of DEC, the prevalence of DEC among foods and fecal specimens of cattle, pigs, chickens, healthy carriers, and patients in Osaka and Hyogo, Japan, was investigated using a multiplex real-time PCR assay. The most prevalent virulence genes were astA and eae, with prevalences of 46.8% and 27.4%, respectively. stx1 (26.6%) and stx2 (45.9%) were prevalent in cattle feces, and est (8...
March 28, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28358967/acute-bilateral-photoreceptor-degeneration-in-an-infant-after-vaccination-against-measles-and-rubella
#16
Kazuki Kuniyoshi, Yoshikazu Hatsukawa, Sadami Kimura, Takahiro Fujino, Hiroshi Ohguro, Rie Nakai, Kenta Sunami, So-Ichiro Mishima, Tomoko Sato, Shunji Kusaka, Yasuhiro Suzuki, Yoshikazu Shimomura
Importance: Ocular inflammation is occasionally observed after vaccinations, and most of them resolve without permanent visual disturbances. However, there are some rare cases of severe ocular complications following vaccinations. Objective: To report the findings in an infant boy who developed an acute loss of vision bilaterally after Haemophilus influenzae type b, Pneumococcal conjugate vaccination, and measles and rubella vaccination. His vision did not recover...
May 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28330887/usefulness-of-two-aspergillus-pcr-assays-and-aspergillus-galactomannan-and-%C3%AE-d-glucan-testing-of-bronchoalveolar-lavage-fluid-for-diagnosis-of-chronic-pulmonary-aspergillosis
#17
Naohisa Urabe, Susumu Sakamoto, Go Sano, Junko Suzuki, Akira Hebisawa, Yasuhiko Nakamura, Kazuya Koyama, Yoshikazu Ishii, Kazuhiro Tateda, Sakae Homma
We evaluated the usefulness of an Aspergillus galactomannan (GM) test, a β-d-glucan (βDG) test, and two different Aspergillus PCR assays of bronchoalveolar lavage fluid (BALF) samples for the diagnosis of chronic pulmonary aspergillosis (CPA). BALF samples from 30 patients with and 120 patients without CPA were collected. We calculated the sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio for each test individually and in combination with other tests...
June 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28296195/evaluation-of-the-infection-risk-in-dialysis-and-chronic-kidney-disease-patients-using-an-atp-monitoring-assay
#18
Junichi Kusano, Rei Kato, Hiroto Matsuda, Yoshikazu Hara, Yoshiaki Fujii, Shinya Suzuki, Masao Sekiyama, Eiki Ando, Kentaro Sugiyama, Toshihiko Hirano
The ATP monitoring assay is a useful biomarker for risk monitoring to detect infection and rejection episodes in transplant recipients. Hemodialysis patients have a higher rate of infectious mortality. Infections in hemodialysis patients are mainly caused by venous catheters, uremia, malnutrition and inflammation. However, the risk of infection episodes has not been evaluated using a lymphocyte ATP monitoring assay in hemodialysis and chronic kidney disease (CKD) patients. We measured the ATP amounts in the peripheral CD4+ cells of CKD (N = 85) and dialysis patients (N = 17) using an "Immuknow" assay kit...
March 13, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28282247/effect-of-tenofovir-disoproxil-fumarate-on-incidence-of-chronic-kidney-disease-and-rate-of-estimated-glomerular-filtration-rate-decrement-in-hiv-1-infected-treatment-na%C3%A3-ve-asian-patients-results-from-12-year-observational-cohort
#19
Soichiro Suzuki, Takeshi Nishijima, Yohei Kawasaki, Takuma Kurosawa, Yoshikazu Mutoh, Yoshimi Kikuchi, Hiroyuki Gatanaga, Shinichi Oka
Little evidence is available for the incidence of chronic kidney disease (CKD) and rate of estimated glomerular filtration rate (eGFR) decrement among Asians with low body weight who are susceptible to tenofovir disoproxil fumarate (TDF) nephrotoxicity. In this 12-year observational cohort in Tokyo, we examined 1383 treatment-naïve HIV-1-infected Asians [720 started TDF-containing (TDF group) and 663 started non-TDF-containing (control) combination antiretroviral therapy (cART)]. The CKD incidence was calculated, and the effect of TDF use on CKD development was estimated using logistic regression...
March 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28269999/baseline-mri-bone-erosion-predicts-the-subsequent-radiographic-progression-in-early-rheumatoid-arthritis-patients-who-achieved-sustained-good-clinical-response
#20
Mami Tamai, Kazuhiko Arima, Yoshikazu Nakashima, Junko Kita, Masataka Umeda, Shoichi Fukui, Ayako Nishino, Takahisa Suzuki, Yoshiro Horai, Akitomo Okada, Tomohiro Koga, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Satoshi Yamasaki, Hideki Nakamura, Tomoki Origuchi, Kiyoshi Aoyagi, Masataka Uetani, Katsumi Eguchi, Atsushi Kawakami
OBJECTIVE: To examine whether magnetic resonance imaging (MRI) findings at baseline predict radiographic progression in early-stage rheumatoid arthritis (RA) patients who have achieved sustained good clinical response. METHODS: This is a sub-analysis from the one-year observational study of Nagasaki University Early Arthritis Cohort. Definition of 'good clinical response' was a decrement of disease activity score (DAS) 28 ≧ 1.2 at three months with achievement of DAS28 remission through 6-12 months...
March 8, 2017: Modern Rheumatology
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