keyword
MENU ▼
Read by QxMD icon Read
search

Yoshikazu Suzuki

keyword
https://www.readbyqxmd.com/read/29791248/ddy-mice-fed-10-fat-diet-exhibit-high-p27kip-expression-and-delayed-hepatocyte-dna-synthesis-during-liver-regeneration
#1
Yohei Saito, Yoshikazu Kuwahara, Yumi Yamamoto, Masatoshi Suzuki, Manabu Fukumoto, Fumihiko Yamamoto
BACKGROUND: Excessive intake of a high-calorie diet has been implicated in the development of non-alcoholic fatty liver disease (NAFLD). Several studies have investigated the effect of NAFLD on liver regeneration, but the effects of simple steatosis have been found to be inconsistent. We aimed to assess whether the initial phase of diet-induced lipid accumulation, induced by a diet containing moderate levels of fat, impairs liver regeneration after partial hepatectomy (PHx) of mice. METHODS: Male ddY mice are prone to obesity, even when fed a relatively low-fat diet (FD)...
May 23, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29730616/study-protocol-for-the-g-spirit-trial-a-randomised-placebo-controlled-double-blinded-phase-iii-trial-of-granulocyte-colony-stimulating-factor-mediated-neuroprotection-for-acute-spinal-cord-injury
#2
Masao Koda, Hideki Hanaoka, Takatoshi Sato, Yasuhisa Fujii, Michiko Hanawa, Sho Takahashi, Takeo Furuya, Yasushi Ijima, Junya Saito, Mitsuhiro Kitamura, Seiji Ohtori, Yukei Matsumoto, Tetsuya Abe, Kei Watanabe, Toru Hirano, Masayuki Ohashi, Hirokazu Shoji, Tatsuki Mizouchi, Ikuko Takahashi, Norio Kawahara, Masahito Kawaguchi, Yugo Orita, Takeshi Sasamoto, Masahito Yoshioka, Masafumi Fujii, Katsutaka Yonezawa, Daisuke Soma, Hiroshi Taneichi, Daisaku Takeuchi, Satoshi Inami, Hiroshi Moridaira, Haruki Ueda, Futoshi Asano, Yosuke Shibao, Ikuo Aita, Yosuke Takeuchi, Masaya Mimura, Jun Shimbo, Yukio Someya, Sumio Ikenoue, Hiroaki Sameda, Kan Takase, Yoshikazu Ikeda, Fumitake Nakajima, Mitsuhiro Hashimoto, Tomoyuki Ozawa, Fumio Hasue, Takayuki Fujiyoshi, Koshiro Kamiya, Masahiko Watanabe, Hiroyuki Katoh, Yukihiro Matsuyama, Yu Yamamoto, Daisuke Togawa, Tomohiko Hasegawa, Sho Kobayashi, Go Yoshida, Shin Oe, Tomohiro Banno, Hideyuki Arima, Koji Akeda, Eiji Kawamoto, Hiroshi Imai, Toshihiko Sakakibara, Akihiro Sudo, Yasuo Ito, Tsuyoshi Kikuchi, Shuhei Osaki, Nobuhiro Tanaka, Kazuyoshi Nakanishi, Naosuke Kamei, Shinji Kotaka, Hideo Baba, Tsuyoshi Okudaira, Hiroaki Konishi, Takayuki Yamaguchi, Keigo Ito, Yoshito Katayama, Taro Matsumoto, Tomohiro Matsumoto, Masaru Idota, Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Toshimitsu Eto, Takehiro Sugaya, Michiharu Matsuda, Kazunari Fushimi, Satoshi Nozawa, Chizuo Iwai, Toshihiko Taguchi, Tsukasa Kanchiku, Hidenori Suzuki, Norihiro Nishida, Masahiro Funaba, Masashi Yamazaki
INTRODUCTION: Granulocyte colony-stimulating factor (G-CSF) is generally used for neutropaenia. Previous experimental studies revealed that G-CSF promoted neurological recovery after spinal cord injury (SCI). Next, we moved to early phase of clinical trials. In a phase I/IIa trial, no adverse events were observed. Next, we conducted a non-randomised, non-blinded, comparative trial, which suggested the efficacy of G-CSF for promoting neurological recovery. Based on those results, we are now performing a phase III trial...
May 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29668871/transgenic-mice-overexpressing-srebp-1a-in-male-ob-ob-mice-exhibit-lipodystrophy-and-exacerbate-insulin-resistance
#3
Hiroshi Ohno, Takashi Matsuzaka, Nie Tang, Rahul Sharma, Kaori Motomura, Takuya Shimura, Aoi Satoh, Song-Iee Han, Yoshinori Takeuchi, Yuichi Aita, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Motohiro Sekiya, Yoshimi Nakagawa, Hirohito Sone, Naoya Yahagi, Nobuhiro Yamada, Yoshikazu Higami, Hitoshi Shimano
Sterol regulatory element-binding protein-1a (SREBP-1a) is a key transcription factor which activates the expression of genes involved in the synthesis of fatty acids, triglycerides, and cholesterol. Transgenic mice that overexpress the nuclear form of SREBP-1a under the control of phosphoenolpyruvate carboxykinase (PEPCK) promoter (Tg-1a) were previously shown to display a lipodystrophic phenotype characterized by enlarged and fatty livers, diminished peripheral white adipose tissue (WAT), and insulin resistance...
April 12, 2018: Endocrinology
https://www.readbyqxmd.com/read/29650861/-the-influence-of-the-timing-of-ceasing-or-withholding-chemotherapy-in-home-based-end-of-life-care-in-patients-with-incurable-solid-cancer-release-of-an-interim-report-of-the-questionnaire-survey-to-home-care-doctors-in-japan
#4
Toshikazu Sakuyama, Yoshikazu Asino, Masahito Tanimizu, Fumio Ogasawara, Akitaka Yoshizawa, Hiroshi Suzuki, Kunihiko Watanabe, Manabu Ohnuki, Mitsunori Nishikawa, Akemi Katami, Noriyasu Shirotani
BACKGROUND: The study analyzes a questionnaire on the potential discriminative characteristics of patients with incurable solidcancer, who either receivedor didnot receive palliative chemotherapy while receiving home-basedend -of-life care. From the standpoint of regional palliative care, we sought to investigate the influence of the timing of when chemotherapy was ceasedor withheldin home-basedend -of-life care in patients with incurable solidcancer. We plannedthe project to obtain scientific evidence about the timing of ceasing or withholding chemotherapy...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29603213/associations-of-cigarette-smoking-and-alcohol-drinking-with-stomach-cancer-survival-a-prospective-patient-cohort-study-in-japan
#5
Yuko Minami, Seiki Kanemura, Tomoyuki Oikawa, Shinichi Suzuki, Yasuhiro Hasegawa, Koh Miura, Yoshikazu Nishino, Yoichiro Kakugawa, Tsuneaki Fujiya
Cigarette smoking and alcohol drinking may affect the prognosis of stomach cancer, but evidence has been inconsistent. We investigated the associations between pretreatment smoking and alcohol drinking and the risk of all-cause and stomach cancer death among 1,576 patients with histologically confirmed stomach cancer diagnosed during 1997-2010 at a single hospital in Japan. Histories of smoking and alcohol drinking were assessed using a self-administered questionnaire. The patients were followed until December 31, 2013...
March 30, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29566670/the-dna-methylation-profile-of-liver-tumors-in-c3h-mice-and-identification-of-differentially-methylated-regions-involved-in-the-regulation-of-tumorigenic-genes
#6
Junya Matsushita, Kazuyuki Okamura, Kazuhiko Nakabayashi, Takehiro Suzuki, Yu Horibe, Tomoko Kawai, Toshihiro Sakurai, Satoshi Yamashita, Yoshikazu Higami, Gaku Ichihara, Kenichiro Hata, Keiko Nohara
BACKGROUND: C3H mice have been frequently used in cancer studies as animal models of spontaneous liver tumors and chemically induced hepatocellular carcinoma (HCC). Epigenetic modifications, including DNA methylation, are among pivotal control mechanisms of gene expression leading to carcinogenesis. Although information on somatic mutations in liver tumors of C3H mice is available, epigenetic aspects are yet to be clarified. METHODS: We performed next generation sequencing-based analysis of DNA methylation and microarray analysis of gene expression to explore genes regulated by DNA methylation in spontaneous liver tumors of C3H mice...
March 22, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29516889/-mycobacterium-abscessus-subsp-abscessus-lung-disease-drug-susceptibility-testing-in-sputum-culture-negative-conversion
#7
Takehiko Kobayashi, Kazunari Tsuyuguchi, Shiomi Yoshida, Yu Kurahara, Naoya Ikegami, Maiko Naito, Shoko Sonobe, Toshiya Maekura, Taisuke Tsuji, Shojiro Minomo, Yoshikazu Inoue, Katsuhiro Suzuki
Background: Among Mycobacterium abscessus complex infections, patients with M. abscessus subsp. abscessus (MAA) lung disease are difficult to treat and no standard therapy has been established. Few reports have investigated the drug susceptibility of these strains. We retrospectively investigated how in vitro drug susceptibility testing (DST) of MAA affects the induction of sputum conversion using pharmacotherapy. Methods: Patients with MAA lung disease diagnosed and treated between 2010 and 2014 at our hospital were enrolled and divided into Group A (sputum conversion without relapse within 1 year) and Group B (persistent positive cultured or negative conversion with relapse)...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29507423/expansions-of-intronic-tttca-and-tttta-repeats-in-benign-adult-familial-myoclonic-epilepsy
#8
Hiroyuki Ishiura, Koichiro Doi, Jun Mitsui, Jun Yoshimura, Miho Kawabe Matsukawa, Asao Fujiyama, Yasuko Toyoshima, Akiyoshi Kakita, Hitoshi Takahashi, Yutaka Suzuki, Sumio Sugano, Wei Qu, Kazuki Ichikawa, Hideaki Yurino, Koichiro Higasa, Shota Shibata, Aki Mitsue, Masaki Tanaka, Yaeko Ichikawa, Yuji Takahashi, Hidetoshi Date, Takashi Matsukawa, Junko Kanda, Fumiko Kusunoki Nakamoto, Mana Higashihara, Koji Abe, Ryoko Koike, Mutsuo Sasagawa, Yasuko Kuroha, Naoya Hasegawa, Norio Kanesawa, Takayuki Kondo, Takefumi Hitomi, Masayoshi Tada, Hiroki Takano, Yutaka Saito, Kazuhiro Sanpei, Osamu Onodera, Masatoyo Nishizawa, Masayuki Nakamura, Takeshi Yasuda, Yoshio Sakiyama, Mieko Otsuka, Akira Ueki, Ken-Ichi Kaida, Jun Shimizu, Ritsuko Hanajima, Toshihiro Hayashi, Yasuo Terao, Satomi Inomata-Terada, Masashi Hamada, Yuichiro Shirota, Akatsuki Kubota, Yoshikazu Ugawa, Kishin Koh, Yoshihisa Takiyama, Natsumi Ohsawa-Yoshida, Shoichi Ishiura, Ryo Yamasaki, Akira Tamaoka, Hiroshi Akiyama, Taisuke Otsuki, Akira Sano, Akio Ikeda, Jun Goto, Shinichi Morishita, Shoji Tsuji
Epilepsy is a common neurological disorder, and mutations in genes encoding ion channels or neurotransmitter receptors are frequent causes of monogenic forms of epilepsy. Here we show that abnormal expansions of TTTCA and TTTTA repeats in intron 4 of SAMD12 cause benign adult familial myoclonic epilepsy (BAFME). Single-molecule, real-time sequencing of BAC clones and nanopore sequencing of genomic DNA identified two repeat configurations in SAMD12. Intriguingly, in two families with a clinical diagnosis of BAFME in which no repeat expansions in SAMD12 were observed, we identified similar expansions of TTTCA and TTTTA repeats in introns of TNRC6A and RAPGEF2, indicating that expansions of the same repeat motifs are involved in the pathogenesis of BAFME regardless of the genes in which the expanded repeats are located...
April 2018: Nature Genetics
https://www.readbyqxmd.com/read/29483461/-significance-of-thoraco-laparoscopic-observation-in-repairing-diaphragmatic-injury-by-the-penetrating-trauma
#9
Daisuke Hara, Gaku Saito, Fumiaki Shimizu, Fumitaka Suzuki, Yoshikazu Arai, Takayuki Shiina
A 53-year-old man with a penetrating trauma was admitted to our hospital. Thoracoabdominal computed tomography (CT) on admission showed left diaphragmatic injury and peritoneal fat in the left thoracic cavity. Under a diagnosis of the traumatic diaphragmatic injury, an emergency operation was performed, and the left diaphragm was repaired. No other injuries were found in the thoracic and abdominal organs by thoraco-laparoscopic observation. The postoperative course was uneventful, and the patient left hospital on the 14th day after surgery...
February 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29458326/global-study-of-holistic-morphological-effectors-in-the-budding-yeast-saccharomyces-cerevisiae
#10
Godai Suzuki, Yang Wang, Karen Kubo, Eri Hirata, Shinsuke Ohnuki, Yoshikazu Ohya
BACKGROUND: The size of the phenotypic effect of a gene has been thoroughly investigated in terms of fitness and specific morphological traits in the budding yeast Saccharomyces cerevisiae, but little is known about gross morphological abnormalities. RESULTS: We identified 1126 holistic morphological effectors that cause severe gross morphological abnormality when deleted, and 2241 specific morphological effectors with weak holistic effects but distinctive effects on yeast morphology...
February 20, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29449519/-supratentorial-meningeal-melanoma-with-nevus-of-ota-a-case-report
#11
Shogo Shima, Shinsuke Sato, Yosuke Moteki, Tatsuya Inoue, Kosuke Suzuki, Yasunari Niimi, Yoshikazu Okada
We present a rare case of supratentorial meningeal melanoma associated with ipsilateral nevus of Ota, and a review of the literature. The patient was a 32-year-old man with a right-sided nevus of Ota, presenting with unconsciousness. His CT and MRI scans revealed an extra axial tumor with dural tail signs; no lesion was detected on systemic examination. Intraoperatively, the tumor demonstrated black hyperpigmentation and was histologically diagnosed as malignant melanoma. Following surgery, he received radiotherapy and chemotherapy...
February 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29386515/infliximab-versus-intravenous-immunoglobulin-for-refractory-kawasaki-disease-a-phase-3-randomized-open-label-active-controlled-parallel-group-multicenter-trial
#12
Masaaki Mori, Takuma Hara, Masako Kikuchi, Hiroyuki Shimizu, Tomoyuki Miyamoto, Satoru Iwashima, Tatsuya Oonishi, Kunio Hashimoto, Norimoto Kobayashi, Kenji Waki, Yasuo Suzuki, Yoshikazu Otsubo, Hiroshi Yamada, Chikao Ishikawa, Taichi Kato, Shigeto Fuse
We compared the efficacy and safety of infliximab with intravenous immunoglobulin (IVIG), a standard therapy, in a phase 3 trial (NCT01596335) for Japanese patients with Kawasaki disease (KD) showing persistent fever after initial IVIG. Patients with initial IVIG-refractory KD, aged 1-10 years, received a single dose of IV infliximab 5 mg/kg or IV polyethylene glycol-treated human immunoglobulin (VGIH) 2 g/kg on day 0. Primary outcome was defervescence rate within 48 h after the start of treatment. Safety was evaluated through day 56...
January 31, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29318457/decreased-intracellular-granule-movement-and-glucagon-secretion-in-pancreatic-%C3%AE-cells-attached-to-superior-cervical-ganglion-neurites
#13
Kiyoto Watabe, Satoru Yokawa, Yoshikazu Inoh, Takahiro Suzuki, Tadahide Furuno
Autonomic neurons innervate pancreatic islets of Langerhans and participate in the maintenance of blood glucose concentrations by controlling hormone levels through attachment with islet cells. We previously found that stimulated superior cervical ganglia (SCG) could induce Ca2+ oscillation in α cells via neuropeptide substance P using an in vitro co-culture model. In this study, we studied the effect of SCG neurite adhesion on intracellular secretory granule movement and glucagon secretion in α cells stimulated by low glucose concentration...
January 9, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29259748/discovery-of-a-slow-tight-binding-lpa1-antagonist-ono-0300302-for-the-treatment-of-benign-prostatic-hyperplasia
#14
Masahiko Terakado, Hidehiro Suzuki, Kazuya Hashimura, Motoyuki Tanaka, Hideyuki Ueda, Keisuke Hirai, Masaki Asada, Masahiro Ikura, Naoki Matsunaga, Hiroshi Saga, Koji Shinozaki, Naoko Karakawa, Yuka Takada, Masashi Minami, Hiromu Egashira, Yoshihiro Sugiura, Masanori Yamada, Shinji Nakade, Yoshikazu Takaoka
Scaffold hopping from the amide group of lead compound ONO-7300243 ( 1 ) to a secondary alcohol successfully gave a novel chemotype lysophosphatidic acid receptor 1 (LPA1 ) antagonist 4 . Wash-out experiments using rat isolated urethra showed that compound 4 possesses a tight binding feature to the LPA1 receptor. Further modification of two phenyl groups of 1 to pyrrole and an indane moiety afforded an optimized compound ONO-0300302 ( 19 ). Despite its high i.v. clearance, 19 inhibited significantly an LPA-induced increase of intraurethral pressure (IUP) in rat (3 mg/kg, p...
December 14, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29232795/-clinical-study-of-testicular-fasciotomy-for-testicular-torsion
#15
Seiji Nagasawa, Akihiro Kanematsu, Yasuhiro Shinkai, Kimihiro Shimatani, Takahiko Hashimoto, Yoshikazu Togo, Toru Suzuki, Shuken Go, Michio Nojima, Shingo Yamamoto
Between November 2011 and November 2014, we performed a tunica albuginea incision with tunica vaginalis flap coverage (TAI+TVFC) on 5 out of 15 patients who underwent surgery for testicular torsion. Of those 15 patients, 7 underwent orchidopexy alone (Group A), 5 underwent TAI+TVFC (Group B), and 3 underwent an orchidectomy procedure (Group C). All were followed for 1 year and preservation of testicular volume >50% on the contralateral side in ultrasound measurements was considered as salvaged. During the follow-up examinations, no testicular atrophy was noted in Group A...
November 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29227218/association-between-sequevar-and-antibiotic-treatment-outcome-in-patients-with-mycobacterium-abscessus-complex-infections-in-japan
#16
Shiomi Yoshida, Kazunari Tsuyuguchi, Takehiko Kobayashi, Motohisa Tomita, Yoshikazu Inoue, Seiji Hayashi, Katsuhiro Suzuki
PURPOSE: Macrolide susceptibility differs between subspecies in the Mycobacterium abscessus complex, likely due to differences in erm(41) sequevars. Patients with M. abscessus complex infection generally show poor clinical outcomes in response to antibiotic treatment. Here, the association between genotype and treatment outcome was investigated. METHODOLOGY: We collected 69 isolates from 35 patients with non-cystic fibrosis bronchiectasis: 24 had M. abscessus complex lung disease and non-cystic fibrosis bronchiectasis, and 11 were colonized...
January 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29212449/maternal-variant-in-the-upstream-of-foxp3-gene-on-the-x-chromosome-is-associated-with-recurrent-infertility-in-japanese-black-cattle
#17
Taichi Arishima, Shinji Sasaki, Tomohiro Isobe, Yoshihisa Ikebata, Shinichi Shimbara, Shogo Ikeda, Keisuke Kawashima, Yutaka Suzuki, Manabu Watanabe, Sumio Sugano, Kazunori Mizoshita, Yoshikazu Sugimoto
BACKGROUND: Repeat breeding, which is defined as cattle failure to conceive after three or more inseminations in the absence of clinical abnormalities, is a substantial problem in cattle breeding. To identify maternal genetic variants of repeat breeding in Japanese Black cattle, we selected 29 repeat-breeding heifers that failed to conceive following embryo transfer (ET) and conducted a genome-wide association study (GWAS) using the traits. RESULTS: We found that a single-nucleotide polymorphism (SNP; g...
December 6, 2017: BMC Genetics
https://www.readbyqxmd.com/read/29114586/calcification-process-dynamics-in-coral-primary-polyps-as-observed-using-a-calcein-incubation-method
#18
Yoshikazu Ohno, Akira Iguchi, Chuya Shinzato, Mikako Gushi, Mayuri Inoue, Atsushi Suzuki, Kazuhiko Sakai, Takashi Nakamura
Calcification processes are largely unknown in scleractinian corals. In this study, live confocal imaging was used to elucidate the spatiotemporal dynamics of the calcification process in aposymbiotic primary polyps of the coral species Acropora digitifera . The fluorophore calcein was used as a calcium deposition marker and a visible indicator of extracellular fluid distribution at the tissue-skeleton interface (subcalicoblastic medium, SCM) in primary polyp tissues. Under continuous incubation in calcein-containing seawater, initial crystallization and skeletal growth were visualized among the calicoblastic cells in live primary polyp tissues...
March 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29095798/relationship-between-initial-vancomycin-trough-levels-and-early-onset-vancomycin-associated-nephrotoxicity-in-critically-ill-patients
#19
Masayuki Chuma, Makoto Makishima, Toru Imai, Naohiro Tochikura, Shinichiro Suzuki, Tsukasa Kuwana, Nami Sawada, Tomohide Komatsu, Takako Sakaue, Norikazu Kikuchi, Yoshikazu Yoshida, Kosaku Kinoshita
BACKGROUND: Appropriate initial dosing of vancomycin (VCM) is important in improving survival and in preventing nephrotoxicity in critically ill patients, but the potential relationship between initial VCM trough levels and early-onset nephrotoxicity remains unclear. We examined the relationship between initial VCM trough levels and early-onset VCM-associated nephrotoxicity. METHODS: We performed a retrospective study of patients who had therapeutic drug monitoring of VCM with initial trough levels within 4 days after the beginning of VCM administration...
February 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29093383/clinical-features-of-hereditary-and-mast-cell-mediated-angioedema-focusing-on-the-differential-diagnosis-in-japanese-patients
#20
Isao Ohsawa, Daisuke Honda, Atsuko Hisada, Hiroyuki Inoshita, Kisara Onda-Tsueshita, Satoshi Mano, Nobuyuki Sato, Yuya Nakamura, Tatsuo Shimizu, Hiromichi Gotoh, Yoshikazu Goto, Yusuke Suzuki, Yasuhiko Tomino
Objective The present study was designed to identify the clinical characteristics that permit the differential diagnosis of hereditary angioedema (HAE) and mast cell-mediated angioedema (Mast-AE) during the first consultation. Methods The medical histories and laboratory data of 46 patients with HAE and 41 patients with Mast-AE were compared. Results The average age of onset in the HAE group (19.8±9.0 years) was significantly lower than that in the Mast-AE group (35.2±12.0 years). The incidence of familial angioedema (AE) in the HAE group (73...
February 1, 2018: Internal Medicine
keyword
keyword
74196
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"