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Yoshikazu Suzuki

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https://www.readbyqxmd.com/read/27908505/diagnostic-advantage-of-stress-computed-tomography-myocardial-perfusion-over-single-photon-emission-computed-tomography-for-the-assessment-of-myocardial-ischemia
#1
Yasushi Ueki, Atsushi Izawa, Daisuke Kashiwagi, Shigeki Nishiyama, Shinichi Aso, Chihiro Suzuki, Shumpei Sakurai, Kazuhiro Oguchi, Yoshikazu Yazaki, Uichi Ikeda, Koichiro Kuwahara
BACKGROUND: This study compared adenosine stress computed tomography myocardial perfusion (CTP) with single-photon emission computed tomography (SPECT) in the diagnosis of functionally significant coronary artery stenosis using fractional flow reserve (FFR) as reference standard. METHODS: We included a total of 93 coronary arteries from 31 patients in whom at least one vessel with ≥50% stenosis was detected with computed tomography coronary angiography. All patients underwent both SPECT and adenosine stress CTP, followed by invasive coronary angiography (ICA) and FFR...
November 28, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27879498/enhancement-of-death-receptor-4-mediated-apoptosis-and-cytotoxicity-in-renal-cell-carcinoma-cells-by-anisomycin
#2
Yongnan Li, Xiuxian Wu, Xinghua Jin, Jiumei Wang, Yoshikazu Togo, Toru Suzuki, Takahiko Hashimoto, Yusuke Yamada, Yukako Nakanishi, Akihiro Kanematsu, Michio Nojima, Yoshiyuki Kakehi, Shingo Yamamoto
Renal cell carcinoma (RCC) is one of the most drug-resistant malignancies, and an effective therapy is lacking for metastatic RCC. Anisomycin is known to inhibit protein synthesis and induce ribotoxic stress. The aim of this study was to explore whether anisomycin enhances the cytotoxic effects of mapatumumab, a human agonistic monoclonal antibody specific for death receptor 4 (DR4), in human RCC cells. We examined the cytotoxicity of anisomycin alone and in combination with mapatumumab in human RCC cell lines and primary RCC cell cultures...
November 22, 2016: Anti-cancer Drugs
https://www.readbyqxmd.com/read/27867688/usefulness-of-vonoprazan-a-potassium-ion-competitive-acid-blocker-for-primary-eradication-of-helicobacter-pylori
#3
Shinya Yamada, Takumi Kawakami, Yoshikazu Nakatsugawa, Takahiro Suzuki, Hideki Fujii, Naoya Tomatsuri, Hideki Nakamura, Hideki Sato, Yusuke Okuyama, Hiroyuki Kimura, Norimasa Yoshida
AIM: To investigate usefulness of triple therapy with vonoprazan, a potassium ion-competitive acid blocker and antibiotics, for Helicobacter pylori (H. pylori) eradication. METHODS: The H. pylori eradication rate was examined in 2507 patients (2055 undergoing primary eradication and 452 undergoing secondary eradication, excluding patients with subtotal gastrectomy) at the Japanese Red Cross Kyoto Daiichi Hospital from March 2013 to September 2015. For patients treated from March 2013 to February 2015, a proton pump inhibitor (PPI) was used to reduce acid secretion, while vonoprazan was used after March 2015...
November 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27824041/genome-sequence-and-analysis-of-the-japanese-morning-glory-ipomoea-nil
#4
Atsushi Hoshino, Vasanthan Jayakumar, Eiji Nitasaka, Atsushi Toyoda, Hideki Noguchi, Takehiko Itoh, Tadasu Shin-I, Yohei Minakuchi, Yuki Koda, Atsushi J Nagano, Masaki Yasugi, Mie N Honjo, Hiroshi Kudoh, Motoaki Seki, Asako Kamiya, Toshiyuki Shiraki, Piero Carninci, Erika Asamizu, Hiroyo Nishide, Sachiko Tanaka, Kyeung-Il Park, Yasumasa Morita, Kohei Yokoyama, Ikuo Uchiyama, Yoshikazu Tanaka, Satoshi Tabata, Kazuo Shinozaki, Yoshihide Hayashizaki, Yuji Kohara, Yutaka Suzuki, Sumio Sugano, Asao Fujiyama, Shigeru Iida, Yasubumi Sakakibara
Ipomoea is the largest genus in the family Convolvulaceae. Ipomoea nil (Japanese morning glory) has been utilized as a model plant to study the genetic basis of floricultural traits, with over 1,500 mutant lines. In the present study, we have utilized second- and third-generation-sequencing platforms, and have reported a draft genome of I. nil with a scaffold N50 of 2.88 Mb (contig N50 of 1.87 Mb), covering 98% of the 750 Mb genome. Scaffolds covering 91.42% of the assembly are anchored to 15 pseudo-chromosomes...
November 8, 2016: Nature Communications
https://www.readbyqxmd.com/read/27807641/long-term-outcomes-of-endoscopic-submucosal-dissection-for-early-gastric-cancer-a-multicenter-collaborative-study
#5
Satoshi Tanabe, Kenji Ishido, Takayuki Matsumoto, Takashi Kosaka, Ichiro Oda, Haruhisa Suzuki, Junko Fujisaki, Hiroyuki Ono, Noboru Kawata, Tsuneo Oyama, Akiko Takahashi, Hisashi Doyama, Masaaki Kobayashi, Noriya Uedo, Kenta Hamada, Takashi Toyonaga, Fumiaki Kawara, Shinji Tanaka, Yoshikazu Yoshifuku
OBJECTIVE: The indications for endoscopic submucosal dissection (ESD) in patients with early gastric cancer (EGC) have been expanded. However, the long-term outcomes of ESD remain unclear. We retrospectively investigated the long-term outcomes of ESD in patients with EGC. METHODS: We retrospectively studied patients with EGC who underwent ESD at 11 institutions between January 2003 and December 2010. A total of 6456 patients (7979 lesions) who met the absolute indications for ESD and 4202 patients (5781 lesions) who met the expanded indications for ESD were studied...
November 2, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27774128/discovery-of-ono-7300243-from-a-novel-class-of-lysophosphatidic-acid-receptor-1-antagonists-from-hit-to-lead
#6
Masahiko Terakado, Hidehiro Suzuki, Kazuya Hashimura, Motoyuki Tanaka, Hideyuki Ueda, Hiroshi Kohno, Taku Fujimoto, Hiroshi Saga, Shinji Nakade, Hiromu Habashita, Yoshikazu Takaoka, Takuya Seko
Lysophosphatidic acid (LPA) evokes various physiological responses through a series of G protein-coupled receptors known as LPA1-6. A high throughput screen against LPA1 gave compound 7a as a hit. The subsequent optimization of 7a led to ONO-7300243 (17a) as a novel, potent LPA1 antagonist, which showed good efficacy in vivo. The oral dosing of 17a at 30 mg/kg led to reduced intraurethral pressure in rats. Notably, this compound was equal in potency to the α1 adrenoceptor antagonist tamsulosin, which is used in clinical practice to treat dysuria with benign prostatic hyperplasia (BPH)...
October 13, 2016: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27762356/genome-evolution-in-the-allotetraploid-frog-xenopus-laevis
#7
COMPARATIVE STUDY
Adam M Session, Yoshinobu Uno, Taejoon Kwon, Jarrod A Chapman, Atsushi Toyoda, Shuji Takahashi, Akimasa Fukui, Akira Hikosaka, Atsushi Suzuki, Mariko Kondo, Simon J van Heeringen, Ian Quigley, Sven Heinz, Hajime Ogino, Haruki Ochi, Uffe Hellsten, Jessica B Lyons, Oleg Simakov, Nicholas Putnam, Jonathan Stites, Yoko Kuroki, Toshiaki Tanaka, Tatsuo Michiue, Minoru Watanabe, Ozren Bogdanovic, Ryan Lister, Georgios Georgiou, Sarita S Paranjpe, Ila van Kruijsbergen, Shengquiang Shu, Joseph Carlson, Tsutomu Kinoshita, Yuko Ohta, Shuuji Mawaribuchi, Jerry Jenkins, Jane Grimwood, Jeremy Schmutz, Therese Mitros, Sahar V Mozaffari, Yutaka Suzuki, Yoshikazu Haramoto, Takamasa S Yamamoto, Chiyo Takagi, Rebecca Heald, Kelly Miller, Christian Haudenschild, Jacob Kitzman, Takuya Nakayama, Yumi Izutsu, Jacques Robert, Joshua Fortriede, Kevin Burns, Vaneet Lotay, Kamran Karimi, Yuuri Yasuoka, Darwin S Dichmann, Martin F Flajnik, Douglas W Houston, Jay Shendure, Louis DuPasquier, Peter D Vize, Aaron M Zorn, Michihiko Ito, Edward M Marcotte, John B Wallingford, Yuzuru Ito, Makoto Asashima, Naoto Ueno, Yoichi Matsuda, Gert Jan C Veenstra, Asao Fujiyama, Richard M Harland, Masanori Taira, Daniel S Rokhsar
To explore the origins and consequences of tetraploidy in the African clawed frog, we sequenced the Xenopus laevis genome and compared it to the related diploid X. tropicalis genome. We characterize the allotetraploid origin of X. laevis by partitioning its genome into two homoeologous subgenomes, marked by distinct families of 'fossil' transposable elements. On the basis of the activity of these elements and the age of hundreds of unitary pseudogenes, we estimate that the two diploid progenitor species diverged around 34 million years ago (Ma) and combined to form an allotetraploid around 17-18 Ma...
October 19, 2016: Nature
https://www.readbyqxmd.com/read/27756441/study-protocol-for-a-multi-center-randomized-controlled-trial-to-develop-japanese-denture-adhesive-guidelines-for-patients-with-complete-dentures-the-denture-adhesive-guideline-trial-study-protocol-for-a-randomized-controlled-trial
#8
Suguru Kimoto, Yasuhiko Kawai, Atsuko Gunji, Hisatomo Kondo, Taro Nomura, Tomohiko Murakami, Akito Tsuboi, Guang Hong, Shunsuke Minakuchi, Yusuke Sato, Gaku Ohwada, Tetsuya Suzuki, Katsuhiko Kimoto, Noriyuki Hoshi, Makiko Saita, Yoshikazu Yoneyama, Yohei Sato, Masakazu Morokuma, Joji Okazaki, Takeshi Maeda, Kenichiro Nakai, Tetsuo Ichikawa, Kan Nagao, Keiko Fujimoto, Hiroshi Murata, Tadafumi Kurogi, Kazuhiro Yoshida, Masahiro Nishimura, Yasuhiro Nishi, Mamoru Murakami, Toshio Hosoi, Taizo Hamada
BACKGROUND: Denture adhesives, characterized as medical products in 1935 by the American Dental Association, have been considered useful adjuncts for improving denture retention and stability. However, many dentists in Japan are hesitant to acknowledge denture adhesives in daily practice because of the stereotype that dentures should be inherently stable, without the aid of adhesives. The aim of this study is to verify the efficacy of denture adhesives to establish guidelines for Japanese users...
October 18, 2016: Trials
https://www.readbyqxmd.com/read/27681752/the-involvement-of-mitochondrial-membrane-potential-in-cross-resistance-between-radiation-and-docetaxel
#9
Yoshikazu Kuwahara, Mehryar Habibi Roudkenar, Masatoshi Suzuki, Yusuke Urushihara, Motoi Fukumoto, Yohei Saito, Manabu Fukumoto
PURPOSE: To understand the molecular mechanisms underlying cancer cell radioresistance, clinically relevant radioresistant (CRR) cells that continue to proliferate during exposure to 2 Gy/day X-rays for more than 30 days were established. A modified high-density survival assay for anticancer drug screening revealed that CRR cells were resistant to an antimicrotubule agent, docetaxel (DTX). The involvement of reactive oxygen species (ROS) from mitochondria (mtROS) in the cross-resistance to X-rays and DTX was studied...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27613513/a-missense-mutation-in-solute-carrier-family-12-member-1-slc12a1-causes-hydrallantois-in-japanese-black-cattle
#10
Shinji Sasaki, Kiyotoshi Hasegawa, Tomoko Higashi, Yutaka Suzuki, Sumio Sugano, Yasuaki Yasuda, Yoshikazu Sugimoto
BACKGROUND: Hydrallantois is the excessive accumulation of fluid within the allantoic cavity in pregnant animals and is associated with fetal mortality. Although the incidence of hydrallantois is very low in artificial insemination breeding programs in cattle, recently 38 cows with the phenotypic appearance of hydrallantois were reported in a local subpopulation of Japanese Black cattle. Of these, 33 were traced back to the same sire; however, both their parents were reported healthy, suggesting that hydrallantois is a recessive inherited disorder...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27585858/ultrasound-disease-activity-of-bilateral-wrist-and-finger-joints-at-three-months-reflects-the-clinical-response-at-six-months-of-patients-with-rheumatoid-arthritis-treated-with-biologic-disease-modifying-anti-rheumatic-drugs
#11
Shin-Ya Kawashiri, Ayako Nishino, Toshimasa Shimizu, Masataka Umeda, Shoichi Fukui, Yoshikazu Nakashima, Takahisa Suzuki, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Kiyoshi Aoyagi, Atsushi Kawakami
OBJECTIVE: We evaluated whether the early responsiveness of ultrasound synovitis can predict the clinical response in rheumatoid arthritis (RA) patients treated with biologic disease-modifying anti-rheumatic drugs (bDMARDs). METHODS: Articular synovitis was assessed by ultrasound at 22 bilateral wrist and finger joints in 39 RA patients treated with bDMARDs. Each joint was assigned a gray-scale (GS) and power Doppler (PD) score from 0 to 3, and the sum of the GS or PD scores was considered to represent the ultrasound disease activity...
September 1, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27522305/identification-and-comparative-analyses-of-siamois-cluster-genes-in-xenopus-laevis-and-tropicalis
#12
Yoshikazu Haramoto, Tomohito Saijyo, Toshiaki Tanaka, Nobuaki Furuno, Atsushi Suzuki, Yuzuru Ito, Mariko Kondo, Masanori Taira, Shuji Takahashi
Two siamois-related homeobox genes siamois (sia1) and twin (sia2), have been reported in Xenopus laevis. These genes are expressed in the blastula chordin- and noggin-expressing (BCNE) center and the Nieuwkoop center, and have complete secondary axis-inducing activity when over-expressed on the ventral side of the embryo. Using whole genome sequences of X. tropicalis and X. laevis, we identified two additional siamois-related genes, which are tandemly duplicated near sia1 and sia2 to form the siamois gene cluster...
August 10, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27513278/efficacy-and-safety-of-long-term-sirolimus-therapy-for-asian-patients-with-lymphangioleiomyomatosis
#13
Toshinori Takada, Ayako Mikami, Nobutaka Kitamura, Kuniaki Seyama, Yoshikazu Inoue, Katsura Nagai, Masaru Suzuki, Hiroshi Moriyama, Keiichi Akasaka, Ryushi Tazawa, Toyohiro Hirai, Michiaki Mishima, Mie Hayashida, Masaki Hirose, Chikatoshi Sugimoto, Toru Arai, Noboru Hattori, Kentaro Watanabe, Tsutomu Tamada, Hirohisa Yoshizawa, Kohei Akazawa, Takahiro Tanaka, Keita Yagi, Lisa R Young, Francis X McCormack, Koh Nakata
RATIONALE: Sirolimus has been shown in a randomized, controlled clinical trial to stabilize lung function in patients with lymphangioleiomyomatosis (LAM) treated for a 12-month time period; however, the pre-treatment decline in lung function decline after the drug was discontinued, indicating that continued exposure is required to suppress disease progression. OBJECTIVES: To elucidate the durability and tolerability of long-term sirolimus treatment in Asian patients with LAM...
August 11, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27502482/a-case-of-lymphomatosis-cerebri-mimicking-inflammatory-diseases
#14
Takenobu Murakami, Kenji Yoshida, Mari Segawa, Akioh Yoshihara, Akihiko Hoshi, Koichiro Nakamura, Masahiro Ichikawa, Osamu Suzuki, Yuichi Yokoyama, Yasuko Toyoshima, Yoshihiro Sugiura, Hiroshi Ito, Kiyoshi Saito, Yuko Hashimoto, Akiyoshi Kakita, Hitoshi Takahashi, Yoshikazu Ugawa
BACKGROUND: Lymphomatosis cerebri (LC) is a rare subtype of primary central nervous system malignant lymphoma. The typical features of this disease exhibited on magnetic resonance imaging (MRI) without contrast enhancement are similar to those observed with diffuse leukoencephalopathy, mimicking white matter disorders such as encephalitis. Clinical features and examination findings that are suggestive of inflammatory diseases may indeed confound the diagnosis of LC. CASE PRESENTATION: A 66-year-old woman with continuous fever over a two-month period developed left hemiparesis despite presenting in an alert state with normal cognitive function...
2016: BMC Neurology
https://www.readbyqxmd.com/read/27500527/correction-analysis-of-plasma-protein-concentrations-and-enzyme-activities-in-cattle-within-the-ex-evacuation-zone-of-the-fukushima-daiichi-nuclear-plant-accident
#15
Yusuke Urushihara, Koh Kawasumi, Satoru Endo, Kenichi Tanaka, Yasuko Hirakawa, Gohei Hayashi, Tsutomu Sekine, Yasushi Kino, Yoshikazu Kuwahara, Masatoshi Suzuki, Motoi Fukumoto, Hideaki Yamashiro, Yasuyuki Abe, Tomokazu Fukuda, Hisashi Shinoda, Emiko Isogai, Toshiro Arai, Manabu Fukumoto
[This corrects the article DOI: 10.1371/journal.pone.0155069.].
2016: PloS One
https://www.readbyqxmd.com/read/27499626/effect-of-biological-factors-on-successful-measurements-with-skeletal-muscle-1-h-mrs
#16
Tomonori Isobe, Yoshikazu Okamoto, Yuji Hirano, Hiroki Ando, Kenta Takada, Eisuke Sato, Kazuya Shinoda, Kiichi Tadano, Hideyuki Takei, Satoshi Kamizawa, Yutaro Mori, Hiroaki Suzuki
BACKGROUND: Our purpose in this study was to clarify whether differences in subject group attributes could affect data acquisition in proton magnetic resonance spectroscopy ((1)H-MRS). METHODS: Subjects without diabetes mellitus (DM) were divided into two groups (group A, in their 20s; group B, 30-60 years old). Subjects with DM formed group C (30-60 years old). The numbers of subjects were 19, 27, and 22 for group A, B, and C respectively. For all subjects, (1)H-MRS measurements were taken of the soleus muscle (SOL) and the anterior tibial muscle (AT)...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27462217/a-patient-with-giant-rippled-pattern-sebaceoma-in-the-occipital-region
#17
Masayuki Takahashi, Masaru Arima, Yohei Iwata, Kayoko Suzuki, Yoshikazu Mizoguchi, Makoto Kuroda, Kayoko Matsunaga
A 72-year-old male visited a nearby hospital with a large tumor in his occipital region, which had existed since 20 years. Since malignant tumor was suspected, he was referred to our department. At the initial consultation, an elastic-hard, yellow-brown, sessile tumor, measuring 8 × 7 × 5 cm and with a flat surface, was observed in the occipital region. The tumor was resected and covered with artificial dermis. Histopathologically, the lesion was composed of basal-cell-like cells with nest formation in the dermis...
May 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/27448677/lung-adenocarcinoma-may-be-a-more-susceptive-subtype-to-a-dendritic-cell-based-cancer-vaccine-than-other-subtypes-of-non-small-cell-lung-cancers-a-multicenter-retrospective-analysis
#18
Hidenori Takahashi, Shigetaka Shimodaira, Masahiro Ogasawara, Shuichi Ota, Masanori Kobayashi, Hirofumi Abe, Yuji Morita, Kazuhiro Nagai, Shunichi Tsujitani, Masato Okamoto, Yukio Suzuki, Yoichi Nakanishi, Yoshikazu Yonemitsu
OBJECTIVE: The J-SICT DC Vaccine Study Group provides dendritic cell (DC) vaccines for compassionate use under unified cell production and patient treatment regimens. We previously reported beneficial effects of DC vaccines on the overall survival of 62 patients with advanced non-small cell lung cancer (NSCLC) in a single-center analysis. Here, we extended analysis to 260 patients with NSCLC who were treated at six centers. METHODS: Of the 337 patients who met the inclusion criteria, we analyzed 260 patients who received ≥5 peptide-pulsed DC vaccinations once every 2 weeks...
September 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27421969/adipose-gene-expression-profile-changes-with-lung-allograft-reperfusion
#19
Joshua M Diamond, Selim Arcasoy, Jamiela A McDonnough, Joshua R Sonett, Matthew Bacchetta, Frank D'Ovidio, Edward Cantu, Christian A Bermudez, Amika McBurnie, Melanie Rushefski, Laurel H Kalman, Michelle Oyster, Carly D'Errico, Yoshikazu Suzuki, Jon T Giles, Anthony Ferrante, Matthew Lippel, Gopal Singh, David J Lederer, Jason D Christie
Obesity is a risk factor for primary graft dysfunction, a form of lung injury resulting from ischemia reperfusion after lung transplantation, but the impact of ischemia reperfusion on adipose tissue is unknown. We evaluated differential gene expression in thoracic visceral adipose tissue (VAT) before and after lung reperfusion. Total RNA was isolated from thoracic VAT sampled from 6 subjects enrolled in the Lung Transplant Body Composition study before and after allograft reperfusion and quantified using the Human Gene 2...
July 16, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27384149/rapid-improvement-of-clinical-disease-activity-index-cdai-at-3-months-predicts-a-preferable-cdai-outcome-at-1-year-in-active-rheumatoid-arthritis-patients-treated-with-tocilizumab-results-from-an-observational-investigation-of-daily-clinical-practice
#20
Shin-Ya Kawashiri, Ayako Nishino, Takahisa Suzuki, Yoshikazu Nakashima, Yoshiro Horai, Yukitaka Ueki, Toshiyuki Aramaki, Keita Fujikawa, Munetoshi Nakashima, Akitomo Okada, Kiyoshi Migita, Akinari Mizokami, Naoki Matsuoka, Masanobu Mine, Soko Sakito, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Kiyoshi Aoyagi, Katsumi Eguchi, Atsushi Kawakami
OBJECTIVES: To investigate whether the Clinical Disease Activity Index (CDAI) at three months predicts a preferable CDAI outcome at one year in patients with active rheumatoid arthritis (RA) treated with tocilizumab (TCZ). METHODS: Seventy-eight RA patients in the Nagasaki Prefecture, Japan, whose disease activities at baseline were moderate to high as estimated by the CDAI and who had received 8 mg/kg of TCZ every four weeks, were consecutively enrolled in this study from April 2008 to March 2011...
June 22, 2016: Clinical and Experimental Rheumatology
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