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Susanna Lemmelä, Svetlana Solovieva, Rahman Shiri, Christian Benner, Markku Heliövaara, Johannes Kettunen, Verneri Anttila, Samuli Ripatti, Markus Perola, Ilkka Seppälä, Markus Juonala, Mika Kähönen, Veikko Salomaa, Jorma Viikari, Olli T Raitakari, Terho Lehtimäki, Aarno Palotie, Eira Viikari-Juntura, Kirsti Husgafvel-Pursiainen
Sciatica or the sciatic syndrome is a common and often disabling low back disorder in the working-age population. It has a relatively high heritability but poorly understood molecular mechanisms. The Finnish population is a genetic isolate where small founder population and bottleneck events have led to enrichment of certain rare and low frequency variants. We performed here the first genome-wide association (GWAS) and meta-analysis of sciatica. The meta-analysis was conducted across two GWAS covering 291 Finnish sciatica cases and 3671 controls genotyped and imputed at 7...
2016: PloS One
Mohamed F Abdel Rahman, Ingy M Hashad, Khaled Abou-Aisha, Sahar M Abdel Maksoud, Mohamed Z Gad
Aim of the current study was to assess link between EDN K198N SNP, ET-1 serum concentration and AMI in Egyptians. Study cohort consisted of 84 patients at AMI onset and 84 age-matched healthy controls. Endothelin genotypes and concentrations were determined by sequencing and ELISA, respectively. Genotype distribution was not significantly different between AMI patients and controls (p=0.8341). The mean serum ET-1 concentration of patients (13.83±0.7pg/ml) was significantly higher than controls (7.26±0.2pg/ml) (p<0...
October 19, 2016: Clinical and Experimental Pharmacology & Physiology
Luna Rahman, Dongmei Wu, Michael Johnston, Andrew William, Sabina Halappanavar
Titanium dioxide nanoparticles (TiO2NPs) induce lung inflammation in experimental animals. In this study, we conducted a comprehensive toxicogenomic analysis of lung responses in mice exposed to six individual TiO2NPs exhibiting different sizes (8, 20 and 300nm), crystalline structure (anatase, rutile or anatase/rutile) and surface modifications (hydrophobic or hydrophilic) to investigate whether the mechanisms leading to TiO2NP-induced lung inflammation are property specific. A detailed histopathological analysis was conducted to investigate the long-term disease implications of acute exposure to TiO2NPs...
October 19, 2016: Mutagenesis
Musfiqur Rahman, A M Abd El-Aty, Sung-Woo Kim, Sung Chul Shin, Ho-Chul Shin, Jae-Han Shim
In pesticide residue analysis, relatively low-sensitivity traditional detectors, such as UV, diode array, electron-capture, flame photometric, and nitrogen-phosphorus detectors, have been used following classical sample preparation (liquid-liquid extraction and open glass column cleanup); however, the extraction method is laborious, time-consuming, and requires large volumes of toxic organic solvents. A quick, easy, cheap, effective, rugged, and safe method was introduced in 2003 and coupled with selective and sensitive mass detectors to overcome the aforementioned drawbacks...
October 19, 2016: Journal of Separation Science
A Rahman, S M Vasenwala, M Iqbal
Glyceryl trinitrate (GTN) has been used widely as a potent vasodilator to treat heart conditions, such as angina pectoris and chronic heart failure. This study aims to elucidate the effect of exogenous nitric oxide (NO) administration, using GTN, on carbon tetrachloride (CCl4)-induced oxidative stress and liver injury in rats. The results obtained demonstrated that NO generated by the administration of GTN affords protection against CCl4-induced oxidative stress and liver injury. Administration of CCl4 resulted in a significant (p < 0...
October 10, 2016: Human & Experimental Toxicology
Issa Khan, Md Faruk Abdullah, Noor Naemah Abdul Rahman, Mohd Roslan Bin Mohd Nor, Mohd Yakub Zulkifli Bin Mohd Yusoff
This study seeks to discover the best solution for women's property sharing between Islamic and current social practices in Bangladesh. A qualitative method has been adopted to achieve this goal. It is found that the majority of the women are marginalised from their property in the social practice. On the other hand, in the Islamic solution, the property is fixed for all classes of women and is based on a property sharing system called fara'id that takes into account the roles and responsibilities of man and woman in the society...
2016: SpringerPlus
Omar F Rahman, Maurice Y Nahabedian, Jeremy C Sinkin
No abstract text is available yet for this article.
September 2016: Plastic and Reconstructive Surgery. Global Open
Shafiqur Rahman Jabin, Tim Schultz, Peter Hibbert, Catherine Mandel, William Runciman
The objective of this review is to find the best available evidence regarding effectiveness of quality improvement interventions in clinical radiology and the experiences and perspectives of staff and patients. More specifically, the review questions are.
September 2016: JBI Database of Systematic Reviews and Implementation Reports
Mahamud-Ur Rashid, Zillur Rahman, Vanessa Burrowes, Jamie Perin, Munshi Mustafiz, Shirajum Monira, K M Saif-Ur-Rahman, Sazzadul Islam Bhuyian, Md Toslim Mahmud, R Bradley Sack, David Sack, Munirul Alam, Christine Marie George
OBJECTIVE: In urban Dhaka, Bangladesh, 30% of source water samples collected from the households of cholera patients had detectable Vibrio cholerae. These findings indicate an urgent need for a public health intervention for this population. The Crystal VC(®) dipstick test is a rapid method for detecting V.cholerae in stool and water. However, to date no study has investigated the use of the rapid dipstick test for household surveillance of stored drinking water. METHODS: The efficacy of the Crystal VC(®) dipstick test for detecting V...
October 18, 2016: Tropical Medicine & International Health: TM & IH
Elena Azizan, Norlela Sukor, Nor Azmi Kamaruddin, A Rahman A Jamal, Jiri Ceral, Miroslav Solar, Isa Mohamed Rose, Geok Chin Tan
OBJECTIVE: Aldosterone-producing adenoma (APA) is a common curable cause of hypertension. Somatic mutations in five genes (KCNJ5, ATP1A1, ATP2B3, CACNA1D, and CTNNB1) have been found to cause the excess aldosterone production of two thirds of APAs [1-4]. KCNJ5 mutant APAs, the most common and largest, had explicit genotype-phenotype relationship - a low protein expression of KCNJ5 relative to their peritumoural zona glomerulosa (ZG) and a zona fasciculata-like composition [5-6]. Conversely for the other genes, controversy arises on whether they have the opposite cell phenotype [4,7-8]...
September 2016: Journal of Hypertension
Asadur Rahman, Yui Takeshige, Yoshihide Fujisawa, Hirofumi Hitomi, Daisuke Nakano, Akira Nishiyama
OBJECTIVE: Disrupted circadian rhythm of blood pressure is associated with cardiovascular events in metabolic syndrome and obesity. Experiments were conducted to examine the effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on circadian rhythm of blood pressure in a genetic model of obese metabolic syndrome (SHR/NDmcr-cp (+/+) (SHRcp)) and salt-treated obese Otsuka Long Evans Tokushima Fatty (OLETF) rats. DESIGN AND METHOD: Luseogliflozin (10 mg/kg/day, p...
September 2016: Journal of Hypertension
Akira Nishiyama, Abu Sufiun, Yoshihide Fujisawa, Asadur Rahman, Daisuke Nakano, Hirofumi Hitomi
OBJECTIVE: It has been indicated that non-dipper pattern of circadian rhythm of blood pressure (BP) is a great risk of cardiovascular disease, which is accompanied by impaired renal function and proteinuria. Here, we aimed to investigate the circadian rhythm of BP during the progression of renal injury in Dahl salt-sensitive (DSS) hypertensive rats. DESIGN AND METHOD: DSS rats were treated with a high salt diet (HS; 8% NaCl) for 10 weeks (n = 10). RESULTS: Before starting a HS diet, the difference in mean arterial pressure (MAP) between dark and light period was 6...
September 2016: Journal of Hypertension
Md Mostafizur Rahman, Sanaz Khosravi, Kyung Hoon Chang, Sang-Min Lee
This study was designed to investigate the effects of dietary astaxanthin levels on growth performance, feed utilization, muscle pigmentation, and antioxidant capacity in juvenile rainbow trout. Four experimental diets were formulated to contain 0, 50, 75, and 100 mg/kg astaxanthin (designed as AX0, AX50, AX75, and AX100). Each diet was fed to triplicate groups of fish (18.5 g/fish) for 10 weeks. Growth performance and muscle composition of fish were not affected by dietary astaxanthin levels. Total carotenoid concentration in the muscle of fish fed the AX50 diet was higher than that of fish fed the AX0 diet, but no significant differences were observed between these fish and those fed the AX75 and AX100 diets...
September 2016: Preventive Nutrition and Food Science
Ritesh Kumar, Syed Saeed Ahmed, Gulam Sarwar Hashmi, Md Kalim Ansari, Sajjad Abdur Rahman
AIM: The present study was planned to investigate the etiology of injuries and to analyze correlation between clinical and radiological findings in cases of craniomaxillofacial trauma. STUDY DESIGN: An 18 months cross-sectional study was done and 325 patients with maxillofacial fractures were analyzed from January 2013 to June 2014 who reported to the department of oral and maxillofacial surgery, Aligarh, Uttar Pradesh. Data was recorded in a preformed case sheet which included: patient's demographic data, cause of injury, type of injury, treatment plan...
September 2016: Journal of Maxillofacial and Oral Surgery
Md Habibur Rahman, Md Abdul Qader, Syed Saimul Haque, Md Abdullah Al Mamun, Golam Muin Uddin
Posterior reversible encephalopathy syndrome (PRES) is a rare clinical and radiological phenomenon is encountered in children compared to adults. In our center, a 5-yearold boy with steroid-dependent nephrotic syndrome (SDNS) presented with headache and blurring of vision during relapse after a long course of immunosuppressive therapy. Evaluation by computed tomography scan of the brain showed that the child had hypodense areas throughout the occipital region of the brain. All signs of PRES, except papilledema, resolved after seven days of supportive treatment evidenced by subsequent radiological evaluation...
September 2016: Saudi Journal of Kidney Diseases and Transplantation
Jahidur Rahman Khan, Wasimul Bari, A H M Mahbub Latif
No abstract text is available yet for this article.
October 17, 2016: BMC Public Health
Yaacov Anziska, Afsana Rahman
No abstract text is available yet for this article.
October 17, 2016: Muscle & Nerve
Wan Faiziah Wan Abdul Rahman, Nur Asyilla Che Jalil, Hadif Samsudin, Siti Rahmah Hi Merican, Alfred Ky Lam
No abstract text is available yet for this article.
September 2016: Annals of the Academy of Medicine, Singapore
M S Kabir, M A Salam, D N R Paul, M I Hossain, N M F Rahman, Abdullah Aziz, M A Latif
Arsenic pollution became a great problem in the recent past in different countries including Bangladesh. The microlevel studies were conducted to see the spatial variation of arsenic in soils and plant parts contaminated through ground water irrigation. The study was performed in shallow tube well command areas in Sadar Upazila (subdistrict), Faridpur, Bangladesh, where both soil and irrigation water arsenic are high. Semivariogram models were computed to determine the spatial dependency of soil, water, grain, straw, and husk arsenic (As)...
2016: TheScientificWorldJournal
Akm Monwarul Islam, Md Toufiqur Rahman, Abu Hana Chowdhury
Naxos disease is a rare autosomal recessive form of arrhythmogenic right ventricular cardiomyopathy (ARVC) with woolly hair and palmoplantar keratoderma. The cardiomyopathy presents by adolescence with syncope, ventricular tachycardia (VT) of left bundle branch block (LBBB) morphology, and/or ventricular fibrillation. The diagnosis and management of ARVC are at present in evolution; the recently published modified Task Force Criteria for diagnosis and International Task Force consensus statement for treatment of ARVC will hopefully bring about uniformity in recognition and management of Naxos disease as well...
October 2016: Cardiovascular Diagnosis and Therapy
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