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https://www.readbyqxmd.com/read/28330327/role-of-gnb3-net-kcnj11-tcf7l2-and-grl-genes-single-nucleotide-polymorphism-in-the-risk-prediction-of-type-2-diabetes-mellitus
#1
REVIEW
Saliha Rizvi, Syed Tasleem Raza, Qamar Rahman, Farzana Mahdi
Type 2 diabetes (T2DM) is a polygenic metabolic disorder characterized by hyperglycemia occurring as a result of impaired insulin secretion or insulin resistance. Various environmental and genetic factors interact and increase the risk of T2DM and its complications. Among the various genetic factors associated with T2DM, single nucleotide polymorphism in different candidate genes have been studied intensively and the resulting genetic variants have been found to have either positive or negative association with T2DM thereby increasing or decreasing the risk of T2DM, respectively...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330189/defense-response-enhancement-in-strawberry-via-elicitors
#2
Gihan M H Hussein, Tahany M A Abdel-Rahman, A H Alwan
In this study, cell-suspension culture of strawberry (Fragaria × ananassa), cultivars Camarosa, and Sweet Charlie has been established. Embryogenic callus was induced by incubating the in vitro juvenile leaf explants on medium, containing 2-mg/l picloram at dark. Suspension culture was initiated from 4-week-old embryogenic calli in the liquid MS medium with 1-mg/l 2,4-D and 2-mg/l picloram. Suspension culture was maintained by sub-culturing each 3 weeks into a fresh medium. At week 9 after third sub-cultures, torpedo and cotyledonary embryo stages were observed...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329057/coronary-artery-calcification-and-risk-of-cardiovascular-disease-and-death-among-patients-with-chronic-kidney-disease
#3
Jing Chen, Matthew J Budoff, Muredach P Reilly, Wei Yang, Sylvia E Rosas, Mahboob Rahman, Xiaoming Zhang, Jason A Roy, Eva Lustigova, Lisa Nessel, Virginia Ford, Dominic Raj, Anna C Porter, Elsayed Z Soliman, Jackson T Wright, Myles Wolf, Jiang He
Importance: Coronary artery calcification (CAC) is highly prevalent in dialysis-naive patients with chronic kidney disease (CKD). However, there are sparse data on the association of CAC with subsequent risk of cardiovascular disease and all-cause mortality in this population. Objective: To study the prospective association of CAC with risk of cardiovascular disease and all-cause mortality among dialysis-naive patients with CKD. Design, Setting, and Participants: The prospective Chronic Renal Insufficiency Cohort study recruited adults with an estimated glomerular filtration rate of 20 to 70 mL/min/1...
March 22, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28328119/cover-image-volume-173a-number-4-april-2017
#4
Paul Kruszka, Yonit A Addissie, Daniel E McGinn, Antonio R Porras, Elijah Biggs, Matthew Share, T Blaine Crowley, Brian H Y Chung, Gary T K Mok, Christopher C Y Mak, Premala Muthukumarasamy, Meow-Keong Thong, Nirmala D Sirisena, Vajira H W Dissanayake, C Sampath Paththinige, L B Lahiru Prabodha, Rupesh Mishra, Vorasuk Shotelersuk, Ekanem Nsikak Ekure, Ogochukwu Jidechukwu Sokunbi, Nnenna Kalu, Carlos R Ferreira, Jordann-Mishael Duncan, Siddaramappa Jagdish Patil, Kelly L Jones, Julie D Kaplan, Omar A Abdul-Rahman, Annette Uwineza, Leon Mutesa, Angélica Moresco, María Gabriela Obregon, Antonio Richieri-Costa, Vera L Gil-da-Silva-Lopes, Adebowale A Adeyemo, Marshall Summar, Elaine H Zackai, Donna M McDonald-McGinn, Marius George Linguraru, Maximilian Muenke
The cover image, by Paul Kruszka et al., is based on the Original Article 22q11.2 deletion syndrome in diverse populations, DOI: 10.1002/ajmg.a.38199. Individual images are property of the National Human Genome Research Institute and are in the public domain.
April 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28328118/22q11-2-deletion-syndrome-in-diverse-populations
#5
Paul Kruszka, Yonit A Addissie, Daniel E McGinn, Antonio R Porras, Elijah Biggs, Matthew Share, T Blaine Crowley, Brian H Y Chung, Gary T K Mok, Christopher C Y Mak, Premala Muthukumarasamy, Meow-Keong Thong, Nirmala D Sirisena, Vajira H W Dissanayake, C Sampath Paththinige, L B Lahiru Prabodha, Rupesh Mishra, Vorasuk Shotelersuk, Ekanem Nsikak Ekure, Ogochukwu Jidechukwu Sokunbi, Nnenna Kalu, Carlos R Ferreira, Jordann-Mishael Duncan, Siddaramappa Jagdish Patil, Kelly L Jones, Julie D Kaplan, Omar A Abdul-Rahman, Annette Uwineza, Leon Mutesa, Angélica Moresco, María Gabriela Obregon, Antonio Richieri-Costa, Vera L Gil-da-Silva-Lopes, Adebowale A Adeyemo, Marshall Summar, Elaine H Zackai, Donna M McDonald-McGinn, Marius George Linguraru, Maximilian Muenke
22q11.2 deletion syndrome (22q11.2 DS) is the most common microdeletion syndrome and is underdiagnosed in diverse populations. This syndrome has a variable phenotype and affects multiple systems, making early recognition imperative. In this study, individuals from diverse populations with 22q11.2 DS were evaluated clinically and by facial analysis technology. Clinical information from 106 individuals and images from 101 were collected from individuals with 22q11.2 DS from 11 countries; average age was 11.7 and 47% were male...
April 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28327437/evaluating-the-effect-of-antioxidant-agents-on-shear-bond-strength-of-tooth-colored-restorative-materials-after-bleaching-a-systematic-review
#6
REVIEW
Atiyeh Feiz, Hamid Mosleh, Rahman Nazeri
PURPOSE: The main objective of the present study was to make a systematic review of how antioxidant agents affect shear bond strength of tooth-colored restorative materials after bleaching. DATA SOURCES: Electronic search was used to extract the related articles on the targeted key words such as "antioxidant", "dental bleaching" and "shear bond strength" (SBS) from MeSH, PubMed, Medline, and Cochrane electronic data bases. These articles were all published before 2016...
March 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28327193/longitudinal-evaluation-of-aortic-hemodynamics-in-marfan-syndrome-new-insights-from-a-4d-flow-cardiovascular-magnetic-resonance-multi-year-follow-up-study
#7
Julia Geiger, Daniel Hirtler, Kristina Gottfried, Ozair Rahman, Emilie Bollache, Alex J Barker, Michael Markl, Brigitte Stiller
BACKGROUND: The aim of this 4D flow cardiovascular magnetic resonance (CMR) follow-up study was to investigate longitudinal changes in aortic hemodynamics in adolescent patients with Marfan syndrome (MFS). METHODS: 4D flow CMR for the assessment of in-vivo 3D blood flow with full coverage of the thoracic aorta was performed twice (baseline scan t1/follow-up scan t2) in 19 adolescent MFS patients (age at t1: 12.7 ± 3.6 years, t2: 16.2 ± 4.3 years) with a mean follow-up duration of 3...
March 22, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28325789/sex-specific-differences-in-mitochondria-biogenesis-morphology-respiratory-function-and-ros-homeostasis-in-young-mouse-heart-and-brain
#8
Abdel Rahman M Khalifa, Engy A Abdel-Rahman, Ali M Mahmoud, Mohamed H Ali, Maha Noureldin, Saber H Saber, Mahmoud Mohsen, Sameh S Ali
Sex-specific differences in mitochondrial function and free radical homeostasis are reported in the context of aging but not well-established in pathogeneses occurring early in life. Here, we examine if sex disparity in mitochondria function, morphology, and redox status starts early and hence can be implicated in sexual dimorphism in cardiac as well as neurological disorders prevalent at young age. Although mitochondrial activity in the heart did not significantly vary between sexes, female brain exhibited enhanced respiration and higher reserve capacity...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28325476/erectile-dysfunction-in-patients-with-nonalcoholic-fatty-liver-disease
#9
Ahmad Farooq Alsayed Hasanain, Reem Ezzat Mahdy, Ali Mohamed Abdel-Rahman Mahran, Ahmed Serag Mahmoud Safwat, Asmaa Omar Mohamed, Sherif Mohamed Abdel-Aal
BACKGROUND AND STUDY AIMS: There is a lack of studies on erectile dysfunction (ED) in patients diagnosed with nonalcoholic fatty liver disease (NAFLD). The present study aimed to estimate the prevalence of ED in patients with NAFLD and to determine the independent predictors of ED in these patients. PATIENTS AND METHODS: We conducted a prospective, hospital-based study of 192 consecutive male patients with NAFLD. All patients underwent clinical evaluation; abdominal ultrasonography; test for viral hepatitis markers; and estimation of liver chemistry panel, complete blood count, prothrombin time, serum lipids panel, serum testosterone, and fasting serum levels of glucose, insulin, and C-peptide...
March 16, 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/28325116/stem-cell-markers-describe-a-transition-from-somatic-to-pluripotent-cell-states-in-a-rat-model-of-endometriosis
#10
Essam Rashad Othman, Fatma Yassine Meligy, Ayat Abdel-Rahman Sayed, Mohamed Ahmed El-Mokhtar, Abeer Mohamed Refaiy
OBJECTIVE: To study Thy1 as a fibroblast marker, SSEA1 as a marker of intermediate pluripotency, and Oct4 as a marker of established pluripotency in rat model of endometriosis. DESIGN: In vivo animal study. MATERIALS AND METHODS: Endometriosis was induced in 20 albino female rats through autologous transplantation of one uterine horn to mesentery of intestine. Other 20 rats had their horn removed without transplantation (controls). Rats were sacrificed 4 weeks after induction surgery...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28323905/elevated-plasma-levels-of-cardiac-troponin-i-predict-left-ventricular-systolic-dysfunction-in-patients-with-myotonic-dystrophy-type-1-a-multicentre-cohort-follow-up-study
#11
Mark J Hamilton, Yvonne Robb, Sarah Cumming, Helen Gregory, Alexis Duncan, Monika Rahman, Anne McKeown, Catherine McWilliam, John Dean, Alison Wilcox, Maria E Farrugia, Anneli Cooper, Josephine McGhie, Berit Adam, Richard Petty, Cheryl Longman, Iain Findlay, Alan Japp, Darren G Monckton, Martin A Denvir
OBJECTIVE: High sensitivity plasma cardiac troponin-I (cTnI) is emerging as a strong predictor of cardiac events in a variety of settings. We have explored its utility in patients with myotonic dystrophy type 1 (DM1). METHODS: 117 patients with DM1 were recruited from routine outpatient clinics across three health boards. A single measurement of cTnI was made using the ARCHITECT STAT Troponin I assay. Demographic, ECG, echocardiographic and other clinical data were obtained from electronic medical records...
2017: PloS One
https://www.readbyqxmd.com/read/28323885/towards-sustainable-sanitation-management-establishing-the-costs-and-willingness-to-pay-for-emptying-and-transporting-sludge-in-rural-districts-with-high-rates-of-access-to-latrines
#12
Soumya Balasubramanya, Barbara Evans, Richard Hardy, Rizwan Ahmed, Ahasan Habib, N S M Asad, Mominur Rahman, M Hasan, Digbijoy Dey, Louise Fletcher, Miller Alonso Camargo-Valero, Krishna Chaitanya Rao, Sudarshana Fernando
MOTIVATION: Proper management of fecal sludge has significant positive health and environmental externalities. Most research on managing onsite sanitation so far either simulates the costs of, or the welfare effects from, managing sludge in situ in pit latrines. Thus, designing management strategies for onsite rural sanitation is challenging, because the actual costs of transporting sludge for treatment, and sources for financing these transport costs, are not well understood. METHODS: In this paper we calculate the actual cost of sludge management from onsite latrines, and identify the contributions that latrine owners are willing to make to finance the costs...
2017: PloS One
https://www.readbyqxmd.com/read/28323505/pattern-of-uveitis-in-a-referral-hospital-in-bangladesh
#13
Zahedur Rahman, Ziaul Ahsan, Niaz Abdur Rahman, Parthopratim Dutta Majumder
PURPOSE: To report the pattern of uveitis in a tertiary eye care center in Bangladesh. METHODS: Retrospective analysis of all uveitis cases visiting uveitis clinic of Bangladesh Eye Hospital between January, 2009 and April, 2015. RESULTS: In total, 652 patients (mean age 32.3 years, female 47.8%) were included in the study. Uveitis was bilateral in 42.6% of cases. Anterior uveitis was the most common (39.2%) case, closely followed by intermediate uveitis (22...
March 21, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28321946/plant-oil-derived-epoxy-polymers-toward-sustainable-biobased-thermosets
#14
Zhongkai Wang, Liang Yuan, Mitra S Ganewatta, Meghan E Lamm, Md Anisur Rahman, Jifu Wang, Shengquan Liu, Chuanbing Tang
Epoxy polymers (EPs) derived from soybean oil with varied chemical structures are synthesized. These polymers are then cured with anhydrides to yield soybean-oil-derived epoxy thermosets. The curing kinetic, thermal, and mechanical properties are well characterized. Due to the high epoxide functionality per epoxy polymer chain, these thermosets exhibit tensile strength over an order of magnitude higher than a control formulation with epoxidized soybean oil. More importantly, thermosetting materials ranging from soft elastomers to tough thermosets can be obtained simply by using different EPs and/or by controlling feed ratios of EPs to anhydrides...
March 21, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28319606/eus-guided-transgastric-drainage-of-a-post-pancreatectomy-abdominal-fluid-collection-using-a-lumen-apposing-metal-stent
#15
Arvind J Trindade, Merajur Rahman, Sumant Inamdar, Samuel Bitton
No abstract text is available yet for this article.
March 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28319366/magnetic-printing-of-a-biosensor-inexpensive-rapid-sensing-to-detect-picomolar-amounts-of-antigen-with-antibody-functionalized-carbon-nanotubes
#16
Abdel Rahman Abdel Fattah, Ahmed M Abdalla, Sarah Mishriki, Elvira Meleca, Fei Geng, Suvojit Ghosh, Ishwar K Puri
When an antibody (Ab) is immobilized on its surface, a carbon nanotube (CNT) becomes a biosensor that detects the corresponding antigen (Ag) since Ag-Ab complexes formed on the CNT surface moderate the current flow through it. We synthesize a biological ink containing CNTs that are twice functionalized, first with magnetic nanoparticles (MNPs) and thereafter with the anti-c-Myc monoclonal Ab. The ink is pipetted and dynamically self organized by an external magnetic field into a dense electrically conducting sensor strip that measures the decrease in current when a sample containing c-Myc Ag is deposited on it...
March 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28319200/induction-of-immunomodulatory-mir-146a-and-mir-155-in-small-intestinal-epithelium-of-vibrio-cholerae-infected-patients-at-acute-stage-of-cholera
#17
Aziz Bitar, Rituparna De, Silvia Melgar, Kyaw Min Aung, Arman Rahman, Firdausi Qadri, Sun Nyunt Wai, Tahmina Shirin, Marie-Louise Hammarström
The potential immunomodulatory role of microRNAs in small intestine of patients with acute watery diarrhea caused by Vibrio cholerae O1 or enterotoxigenic Escherichia coli (ETEC) infection was investigated. Duodenal biopsies were obtained from study-participants at the acute (day 2) and convalescent (day 21) stages of disease, and from healthy individuals. Levels of miR-146a, miR-155 and miR-375 and target gene (IRAK1, TRAF6, CARD10) and 11 cytokine mRNAs were determined by qRT-PCR. The cellular source of microRNAs in biopsies was analyzed by in situ hybridization...
2017: PloS One
https://www.readbyqxmd.com/read/28319197/the-hiv-care-cascade-japanese-perspectives
#18
Aikichi Iwamoto, Rikizo Taira, Yoshiyuki Yokomaku, Tomohiko Koibuchi, Mahbubur Rahman, Yoko Izumi, Kenji Tadokoro
Japan has been known as a low HIV-prevalence country with a concentrated epidemic among high-risk groups. However, it has not been determined whether Japan meets the 90-90-90 goals set by the Joint United Nations Programme on HIV/AIDS (UNAIDS)/World Health Organization (WHO). Moreover, to date, the HIV care cascade has not been examined. We estimated the total number of diagnosed people living with HIV/AIDS (PLWHA) (n = 22,840) based on legal reports to the Ministry of Health, Labour and Welfare by subtracting the number of foreigners who left Japan (n = 2,273) and deaths (n = 2,321) from the cumulative diagnosis report (n = 27,434)...
2017: PloS One
https://www.readbyqxmd.com/read/28317286/trend-analysis-and-survival-of-primary-gallbladder-cancer-in-the-united-states-a-1973-2009-population-based-study
#19
Rubayat Rahman, Eduardo J Simoes, Chester Schmaltz, Christian S Jackson, Jamal A Ibdah
Primary gallbladder cancer is an aggressive and uncommon cancer with poor outcomes. Our study examines epidemiology, trend, and survival of gallbladder cancer in the United States from 1973 to 2009. We utilized the Surveillance Epidemiology and End Results database (SEER). Frequency and rate analyses on demographics, stage, and survival were compared among non-Hispanic whites, Hispanics, African American, and Asian/Pacific Islanders. A total of 18,124 cases were reported in SEER from 1973 to 2009 comprising 1...
March 20, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28316914/morphometric-analysis-of-prognathic-and-non-prognathic-mandibles-in-relation-to-bsso-sites-using-cbct
#20
Tengku Aszraf Tengku Shaeran, Ramizu Shaari, Shafulizan Abdul Rahman, Mohammad Khursheed Alam, Alauddin Muhamad Husin
BACKGROUND: Bilateral sagittal split osteotomy (BSSO) is the most versatile procedure and adopted by many surgeons to relocate the mandible in patients having mandibular prognathism (MP). Injury to the inferior alveolar nerve (IAN) and unfavorable splits are two surgical complications of BSSO which are associated with mandibular morphology. Uses of cone beam computed tomography (CBCT) in providing 3-D images has gained a wider acceptance in surgical field nowadays. Its advantages are including reduced cost, lesser radiation dose and smaller physical footprint comparing to the conventional computed tomography...
January 2017: Journal of Oral Biology and Craniofacial Research
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