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JOURNAL ARTICLE
Masataka Enomoto, Nicholas de Castro, Jonathan Hash, Andrea Thomson, Aoi Nakanishi-Hester, Erin Perry, Savannah Aker, Emily Haupt, Logan Opperman, Simon Roe, Tracey Cole, Nichola Archer Thompson, J F Innes, B Duncan X Lascelles
This study aimed to determine the prevalence of osteoarthritis (OA) and associated clinical signs in young dogs. Owners of dogs aged 8 months-4 years from a single practice, were contacted in random order, to participate in a general health screen. Clinical and orthopedic examinations were performed. Each joint was scored for pain reactions (0-4). Orthogonal radiographs of all joints were made under sedation. Each joint was scored for radiographic OA (rOA) severity on an 11-point scale. Clinical OA (cOA) was defined as an overlap of rOA and joint pain in ≥ 1 joint...
February 3, 2024: Scientific Reports
#22
Asmit Bhowmick, Rana Hussein, Isabel Bogacz, Philipp S Simon, Mohamed Ibrahim, Ruchira Chatterjee, Margaret D Doyle, Mun Hon Cheah, Thomas Fransson, Petko Chernev, In-Sik Kim, Hiroki Makita, Medhanjali Dasgupta, Corey J Kaminsky, Miao Zhang, Julia Gätcke, Stephanie Haupt, Isabela I Nangca, Stephen M Keable, A Orkun Aydin, Kensuke Tono, Shigeki Owada, Leland B Gee, Franklin D Fuller, Alexander Batyuk, Roberto Alonso-Mori, James M Holton, Daniel W Paley, Nigel W Moriarty, Fikret Mamedov, Paul D Adams, Aaron S Brewster, Holger Dobbek, Nicholas K Sauter, Uwe Bergmann, Athina Zouni, Johannes Messinger, Jan Kern, Junko Yano, Vittal K Yachandra
No abstract text is available yet for this article.
January 30, 2024: Nature
#23
JOURNAL ARTICLE
Nesli Avgan, Heidi G Sutherland, Rod A Lea, Larisa M Haupt, David H K Shum, Lyn R Griffiths
Neuropeptides are mostly expressed in regions of the brain responsible for learning and memory and are centrally involved in cognitive pathways. The majority of neuropeptide research has been performed in animal models; with acknowledged differences between species, more research into the role of neuropeptides in humans is necessary to understand their contribution to higher cognitive function. In this study, we investigated the influence of genetic polymorphisms in neuropeptide genes on verbal learning and memory...
December 24, 2023: Genes
#24
JOURNAL ARTICLE
Emma J Heymer, Michael M Hawkins, David L Winter, Jop C Teepen, Ceren Sunguc, Cécile M Ronckers, Rodrigue S Allodji, Daniela Alessi, Elaine Sugden, Fabiën N Belle, Francesca Bagnasco, Julianne Byrne, Edit Bárdi, Stanislaw Garwicz, Desiree Grabow, Momcilo Jankovic, Peter Kaatsch, Melanie Kaiser, Gisela Michel, Christina Schindera, Nadia Haddy, Neige Journy, Maja Česen Mazić, Roderick Skinner, Judith L Kok, Maria W Gunnes, Thomas Wiebe, Carlotta Sacerdote, Milena M Maule, Monica Terenziani, Zsuzsanna Jakab, Jeanette F Winther, Päivi M Lähteenmäki, Lorna Zadravec Zaletel, Riccardo Haupt, Claudia E Kuehni, Leontien C Kremer, Florent de Vathaire, Lars Hjorth, Raoul C Reulen
BACKGROUND: Childhood cancer survivors are at risk of subsequent gliomas and meningiomas, but the risks beyond age 40 years are uncertain. We quantified these risks in the largest ever cohort. METHODS: Using data from 69,460 5-year childhood cancer survivors (diagnosed 1940-2008), across Europe, standardized incidence ratios (SIRs) and cumulative incidence were calculated. RESULTS: In total, 279 glioma and 761 meningioma were identified. CNS tumour (SIR: 16...
January 19, 2024: British Journal of Cancer
#25
REVIEW
Cheryl Carcel, Sue Haupt, Clare Arnott, Mei Ling Yap, Amanda Henry, Jane E Hirst, Mark Woodward, Robyn Norton
Women's health has been critically underserved by a failure to look beyond women's sexual and reproductive systems to adequately consider their broader health needs. In almost every country in the world, noncommunicable diseases are the leading causes of death for women. Among these, cardiovascular disease (including heart disease and stroke) and cancer are the major causes of mortality. Risks for these conditions exist at each stage of women's lives, but recognition of the unique needs of women for the prevention and management of noncommunicable diseases is relatively recent and still emerging...
January 2024: Nature Medicine
#26
Kenny R Coventry, Harmen B Gudde, Holger Diessel, Jacqueline Collier, Pedro Guijarro-Fuentes, Mila Vulchanova, Valentin Vulchanov, Emanuela Todisco, Maria Reile, Merlijn Breunesse, Helen Plado, Juergen Bohnemeyer, Raed Bsili, Michela Caldano, Rositsa Dekova, Katharine Donelson, Diana Forker, Yesol Park, Lekhnath Sharma Pathak, David Peeters, Gabriella Pizzuto, Baris Serhan, Linda Apse, Florian Hesse, Linh Hoang, Phuong Hoang, Yoko Igari, Keerthana Kapiley, Tamar Haupt-Khutsishvili, Sara Kolding, Katri Priiki, Ieva Mačiukaitytė, Vaisnavi Mohite, Tiina Nahkola, Sum Yi Tsoi, Stefan Williams, Shunei Yasuda, Angelo Cangelosi, Jon Andoni Duñabeitia, Ramesh Kumar Mishra, Roberta Rocca, Jurģis Šķilters, Mikkel Wallentin, Eglė Žilinskaitė-Šinkūnienė, Ozlem Durmaz Incel
No abstract text is available yet for this article.
January 9, 2024: Nature Human Behaviour
#27
JOURNAL ARTICLE
Anne Vogel, Anna Haupts, Michael Kloth, Wilfried Roth, Nils Hartmann
Deleterious mutations in the BRCA1 and BRCA2 genes have significant therapeutic relevance in clinical settings regarding personalized therapy approaches. BRCA1 and BRCA2 play a pivotal role in homologous recombination (HR) and thus are sensitive for PARP inhibitors (PARPi). Beyond the narrow scope of evaluating only the BRCA mutation status, PARPi can be beneficial for HR deficient (HRD) patients, who harbor mutations in other HR-associated genes. In the present retrospective study, a novel targeted HRD gene panel was validated and implemented for use with FFPE tissue...
January 6, 2024: Diagnostic Pathology
#28
JOURNAL ARTICLE
Rebecca Tanja Zimmer, Alexander Auth, Janis Schierbauer, Sandra Haupt, Nadine Wachsmuth, Paul Zimmermann, Thomas Voit, Tadej Battelino, Harald Sourij, Othmar Moser
Physical activity and exercise have many beneficial effects on general and type 1 diabetes (T1D) specific health and are recommended for individuals with T1D. Despite these health benefits, many people with T1D still avoid exercise since glycemic management during physical activity poses substantial glycemic and psychological challenges - which hold particularly true for unannounced exercise when using an AID system. Automated insulin delivery (AID) systems have demonstrated their efficacy in improving overall glycemia and in managing announced exercise in numerous studies...
December 22, 2023: Diabetes Technology & Therapeutics
#29
JOURNAL ARTICLE
Ellie Fratt, Eric C Haupt, Susan E Wang, Huong Nguyen
OBJECTIVE: Although prior studies show that exposure to early outpatient palliative care (OPC) versus no exposure is associated with improved outcomes at the end of life (EoL) for patients with cancer, few examined the impact of exposure to OPC prior to home-based palliative care (HBPC) on EoL outcomes. This study compares the effect of OPC prior to HBPC versus HBPC alone on EoL outcomes in patients with cancer. METHODS: A secondary analysis of data from a trial comparing two models of HBPC was performed on patients with primary cancer diagnoses...
December 9, 2023: BMJ Supportive & Palliative Care
#30
JOURNAL ARTICLE
Michael Robert Haupt, Michelle Chiu, Joseline Chang, Zoe Li, Raphael Cuomo, Tim K Mackey
The spread of misinformation and conspiracies has been an ongoing issue since the early stages of the internet era, resulting in the emergence of the field of infodemiology (i.e., information epidemiology), which investigates the transmission of health-related information. Due to the high volume of online misinformation in recent years, there is a need to continue advancing methodologies in order to effectively identify narratives and themes. While machine learning models can be used to detect misinformation and conspiracies, these models are limited in their generalizability to other datasets and misinformation phenomenon, and are often unable to detect implicit meanings in text that require contextual knowledge...
2023: PloS One
#31
JOURNAL ARTICLE
Divya Mehta, Irene de Boer, Heidi G Sutherland, Judith A Pijpers, Charlene Bron, Charlotte Bainomugisa, Larisa M Haupt, Arn M J M van den Maagdenberg, Lyn R Griffiths, Dale R Nyholt, Gisela M Terwindt
BACKGROUND: Chronic migraine, a highly disabling migraine subtype, affects nearly 2% of the general population. Understanding migraine chronification is vital for developing better treatment and prevention strategies. An important factor in the chronification of migraine is the overuse of acute headache medication. However, the mechanisms behind the transformation of episodic migraine to chronic migraine and vice versa have not yet been elucidated. We performed a longitudinal epigenome-wide association study to identify DNA methylation (DNAm) changes associated with treatment response in patients with chronic migraine and medication overuse as part of the Chronification and Reversibility of Migraine clinical trial...
December 12, 2023: Clinical Epigenetics
#32
REVIEW
Benjamin W Gregor, Mackenzie E Coston, Ellen M Adams, Joy Arakaki, Antoine Borensztejn, Thao P Do, Margaret A Fuqua, Amanda Haupt, Melissa C Hendershott, Winnie Leung, Irina A Mueller, Aditya Nath, Angelique M Nelson, Susanne M Rafelski, Emmanuel E Sanchez, Madison J Swain-Bowden, W Joyce Tang, Derek J Thirstrup, Winfried Wiegraebe, Brian P Whitney, Calysta Yan, Ruwanthi N Gunawardane, Nathalie Gaudreault
To produce abundant cell culture samples to generate large, standardized image datasets of human induced pluripotent stem (hiPS) cells, we developed an automated workflow on a Hamilton STAR liquid handler system. This was developed specifically for culturing hiPS cell lines expressing fluorescently tagged proteins, which we have used to study the principles by which cells establish and maintain robust dynamic localization of cellular structures. This protocol includes all details for the maintenance, passage and seeding of cells, as well as Matrigel coating of 6-well plastic plates and 96-well optical-grade, glass plates...
December 12, 2023: Nature Protocols
#33
JOURNAL ARTICLE
Ismay A E de Beijer, Roderick Skinner, Riccardo Haupt, Desiree Grabow, Edit Bardi, Andrea Beccaria, Adela Cañete Nieto, Samira Essiaf, Anna-Liesa Filbert, Hannah Gsell, Anita Kienesberger, Thorsten Langer, Patricia McColgan, Monica Muraca, Jelena Rascon, Ramona Tallone, Zuzana Tomasikova, Anne Uyttebroeck, Leontien C M Kremer, Helena J H van der Pal, Renée L Mulder
PURPOSE: Childhood, adolescent and young adult (CAYA) cancer survivors require ongoing surveillance for health problems from the end of cancer treatment throughout their lives. There is a lack of evidence-based guidelines on optimal surveillance strategies for the period from the end of treatment to 5 years after diagnosis. We aimed to address this gap by developing recommendations for short-term surveillance of health problems based on existing long-term follow-up (LTFU) care guidelines...
December 4, 2023: Journal of Cancer Survivorship: Research and Practice
#34
JOURNAL ARTICLE
Felicia A S Wang, Yamin Fan, Wai Keen Chung, Amit Dutta, Erik Fiedler, Ulrich Haupts, Jamie Peyser, Ralf Kuriyel
Protein A affinity chromatography is widely used as a capture step for monoclonal antibodies (mAb) and molecules that possess an Fc-domain, such as fusion proteins and bispecific antibodies. However, the use of low pH (3.0-4.0) to elute the molecule and achieve acceptable yield (>85 %) can lead to product degradation (e.g. fragmentation, aggregation) for molecules sensitive to low pH. In this paper, we describe a comprehensive evaluation of two protein A resins with ligands designed to elute at a milder pH as a result of modified sequences in their Fc and VH3 binding regions...
November 21, 2023: Journal of Chromatography. A
#35
JOURNAL ARTICLE
Amir El Rahal, Benedikt Haupt, Christian Fung, Debora Cipriani, Levin Häni, Niklas Lützen, Tomas Dobrocky, Eike Piechowiak, Oliver Schnell, Andreas Raabe, Katharina Wolf, Horst Urbach, Luisa Mona Kraus, Florian Volz, Jürgen Beck
BACKGROUND AND PURPOSE: Spinal cerebrospinal fluid (CSF) leaks may cause a myriad of symptoms, most common being orthostatic headache. In addition, ventral spinal CSF leaks are a possible etiology of superficial siderosis (SS), a rare condition characterized by hemosiderin deposits in the central nervous system (CNS). The classical presentation of SS involves ataxia, bilateral hearing loss, and myelopathy. Unfortunately, treatment options are scarce. This study was undertaken to evaluate whether microsurgical closure of CSF leaks can prevent further clinical deterioration or improve symptoms of SS...
November 28, 2023: European Journal of Neurology
#36
JOURNAL ARTICLE
Ismay A E de Beijer, Emma C Hardijzer, Riccardo Haupt, Desiree Grabow, Julia Balaguer, Edit Bardi, Adela Cañete Nieto, Audronė Ciesiūniene, Vanessa Düster, Anna-Liesa Filbert, Hannah Gsell, Monika Kapitančukė, Ruth Ladenstein, Thorsten Langer, Monica Muraca, Selina R van den Oever, Sofie Prikken, Jelena Rascon, Maria Teresa Tormo, Anne Uyttebroeck, Gertrui Vercruysse, Helena J H van der Pal, Leontien C M Kremer, Saskia M F Pluijm
PURPOSE: To identify barriers and facilitators for implementing the Survivorship Passport (SurPass) v2.0 in six long-term follow-up (LTFU) care centres in Europe. METHODS: Stakeholders including childhood cancer survivors (CCSs), healthcare providers (HCPs), managers, information and technology (IT) specialists, and others, participated in six online Open Space meetings. Topics related to Care, Ethical, Legal, Social, Economic, and Information & IT-related aspects of implementing SurPass were evaluated...
November 28, 2023: Journal of Cancer Survivorship: Research and Practice
#37
JOURNAL ARTICLE
Thomas L Haupt, Earl H Harley
OBJECTIVE: To examine head and neck injuries caused by BB (Ball Bearing) guns treated in US emergency departments among children under 18 to identify trends in injury frequency over time and risk factors associated with severe injuries leading to hospital admission. METHODS: This retrospective study utilized data from the National Electronic Injury Surveillance System (NEISS), a single database, to analyze head and neck injuries caused by BB guns between 1993 and 2019...
November 9, 2023: International Journal of Pediatric Otorhinolaryngology
#38
JOURNAL ARTICLE
Wolfgang Lechner, Dávid Kanalas, Sarah Haupt, Lukas Zimmermann, Dietmar Georg
BACKGROUND: To evaluate a novel CBCT conversion algorithm for dose calculation implemented in a research version of a treatment planning system (TPS). METHODS: The algorithm was implemented in a research version of RayStation (v. 11B-DTK, RaySearch, Stockholm, Sweden). CBCTs acquired for each ten head and neck (HN), gynecology (GYN) and lung cancer (LNG) patients were collected and converted using the new algorithm (CBCTc ). A bulk density overriding technique implemented in the same version of the TPS was used for comparison (CBCTb )...
November 16, 2023: Radiation Oncology
#39
JOURNAL ARTICLE
Emma J Heymer, Katarzyna Jóźwiak, Leontien C Kremer, David L Winter, Florent de Vathaire, Ceren Sunguc, Elaine Sugden, Judith L Kok, Helena J H van der Pal, Lars Hjorth, Zsuzsanna Jakab, Milena M Maule, Riccardo Haupt, Francesca Bagnasco, Monica Terenziani, Ibrahima Diallo, Maria W Gunnes, Grit Sommer, Lorna Zadravec Zaletel, Claudia E Kuehni, Jeanette F Winther, Päivi M Lähteenmäki, Thorgerdur Gudmundsdottir, Rodrigue S Allodji, Roderick Skinner, Cécile M Ronckers, Michael M Hawkins, Raoul C Reulen, Jop C Teepen
PURPOSE: Childhood cancer survivors are at the risk of developing subsequent colorectal cancers (CRCs), but the absolute risks by treatment modality are uncertain. We quantified the absolute risks by radiotherapy treatment characteristics using clinically accessible data from a Pan-European wide case-control study nested within a large cohort of childhood cancer survivors: the PanCareSurFup Study. METHODS: Odds ratios (ORs) from a case-control study comprising 143 CRC cases and 143 controls nested within a cohort of 69,460 survivors were calculated...
November 16, 2023: Journal of Clinical Oncology
#40
JOURNAL ARTICLE
Patricia J Rodriguez, Patrick J Heagerty, Samantha Clark, Sara Khor, Yilin Chen, Eric Haupt, Erin E Hahn, Veena Shankaran, Aasthaa Bansal
PURPOSE: The risk of colorectal cancer (CRC) recurrence after primary treatment varies across individuals and over time. Using patients' most up-to-date information, including carcinoembryonic antigen (CEA) biomarker profiles, to predict risk could improve personalized decision making. METHODS: We used electronic health record data from an integrated health system on a cohort of patients diagnosed with American Joint Committee on Cancer stage I-III CRC between 2008 and 2013 (N = 3,970) and monitored until recurrence or end of follow-up...
September 2023: JCO Clinical Cancer Informatics
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