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https://www.readbyqxmd.com/read/29232700/sygl-1-and-lst-1-link-niche-signaling-to-puf-rna-repression-for-stem-cell-maintenance-in-caenorhabditis-elegans
#1
Heaji Shin, Kimberly A Haupt, Aaron M Kershner, Peggy Kroll-Conner, Marvin Wickens, Judith Kimble
Central questions in regenerative biology include how stem cells are maintained and how they transition from self-renewal to differentiation. Germline stem cells (GSCs) in Caenorhabditis elegans provide a tractable in vivo model to address these questions. In this system, Notch signaling and PUF RNA binding proteins, FBF-1 and FBF-2 (collectively FBF), maintain a pool of GSCs in a naïve state. An open question has been how Notch signaling modulates FBF activity to promote stem cell self-renewal. Here we report that two Notch targets, SYGL-1 and LST-1, link niche signaling to FBF...
December 12, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29232068/dynamic-evaluation-of-a-trilobal-capillary-channeled-polymer-fiber-shape-for-reversed-phase-protein-separations-and-comparison-to-the-eight-channeled-form
#2
Lei Wang, Kathryn A Stevens, Paul Haupt-Renaud, R Kenneth Marcus
A new, trilobal shaped capillary-channeled polymer fiber is under development to address the issues of poor A-term performance of the previous eight-channeled form. The trilobal geometry should provide better packing homogeneity due to the fewer potential orientations of the symmetric fiber geometry. Comparisons of separation efficiency and peak shape were made between the two fiber shapes through several dynamic parameters. Column hydrodynamics were investigated with two marker compounds, uracil and bovine serum albumin, with van Deemter plots of those two compounds revealing differences in the packing qualities between the different fiber shapes...
December 12, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29223216/proud-and-grateful-to-be-a-nurse-and-an-educator
#3
Rachael Haupt-Harrington
No abstract text is available yet for this article.
December 2017: Nursing for Women's Health
https://www.readbyqxmd.com/read/29215094/expression-qtl-analysis-of-glaucoma-endophenotypes-in-the-norfolk-island-isolate-provides-evidence-that-immune-related-genes-are-associated-with-optic-disc-size
#4
Pik Fang Kho, Rodney A Lea, Miles C Benton, David Eccles, Larisa M Haupt, Alex W Hewitt, Justin C Sherwin, David A Mackey, Lyn R Griffiths
Primary open-angle glaucoma (POAG) is influenced by both genetic and environmental factors. Despite significant progress in identifying genetic variants associated with POAG, there remains a substantial amount of unexplained heritability. Study design features that may enhance knowledge of the genetic architecture include focusing on multiple quantitative traits related to ocular disorders (i.e. endophenotypes), targeting genetic variants that directly influence gene expression (i.e. cis-eQTLs) and utilising genetically isolated populations to reduce genetic and environmental noise and thus enhance association signals...
November 16, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/29177076/effectiveness-and-efficiency-of-different-weight-machine-based-strength-training-programmes-for-patients-with-hip-or-knee-osteoarthritis-a-protocol-for-a-quasi-experimental-controlled-study-in-the-context-of-health-services-research
#5
Inga Krauss, Gerhard Müller, Benjamin Steinhilber, Georg Haupt, Pia Janssen, Peter Martus
Introduction: Osteoarthritis is a chronic musculoskeletal disease with a major impact on the individual and the healthcare system. As there is no cure, therapy aims for symptom release and reduction of disease progression. Physical exercises have been defined as a core treatment for osteoarthritis. However, research questions related to dose response, sustainability of effects, economic efficiency and safety are still open and will be evaluated in this trial, investigating a progressive weight machine-based strength training...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29167192/cytokeratin-18-and-enhanced-liver-fibrosis-scores-in-type-1-and-type-2-diabetes-and-effects-of-two-different-insulins
#6
Arun Sanyal, Kenneth Cusi, Mark L Hartman, Shuyu Zhang, Edward J Bastyr, Juliana M Bue-Valleskey, Annette M Chang, Axel Haupt, Scott J Jacober, Robert J Konrad, Qianyi Zhang, Byron J Hoogwerf
Data on cytokeratin-18 (K-18) and enhanced liver fibrosis (ELF) score in insulin-treated diabetes patients with non-alcoholic fatty liver disease (NAFLD) are limited. This study analyzed phase III data comparing basal insulin peglispro (BIL) and insulin glargine in type 1 (T1D), and type 2 diabetes (T2D) (insulin-naïve and insulin-treated). Alanine aminotransferase (ALT), K-18, ELF scores and liver fat content (LFC), measured by MRI, were obtained longitudinally. Baseline K-18 (U/L) was higher in T2D (range: 207‒247) than T1D (range: 148‒183), correlated with ALT in all populations (r (range) 0...
November 21, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29165710/risk-of-soft-tissue-sarcoma-among-69-460-five-year-survivors-of-childhood-cancer-in-europe
#7
Chloe J Bright, Mike M Hawkins, David L Winter, Daniela Alessi, Rodrigue S Allodji, Francesca Bagnasco, Edit Bárdi, Andrea Bautz, Julianne Byrne, Elizabeth A M Feijen, Miranda M Fidler, Stanislaw Garwicz, Desiree Grabow, Thorgerdur Gudmundsdottir, Joyeeta Guha, Nadia Haddy, Momcilo Jankovic, Peter Kaatsch, Melanie Kaiser, Claudia E Kuehni, Helena Linge, Hilde Øfstaas, Cecile M Ronckers, Roderick Skinner, Jop C Teepen, Monica Terenziani, Giao Vu-Bezin, Finn Wesenberg, Thomas Wiebe, Carlotta Sacerdote, Zsuzsanna Jakab, Riccardo Haupt, Päivi Lähteenmäki, Lorna Zadravec Zaletel, Rahel Kuonen, Jeanette F Winther, Florent de Vathaire, Leontien C Kremer, Lars Hjorth, Raoul C Reulen
Background: Childhood cancer survivors are at risk of subsequent primary soft-tissue sarcomas (STS), but the risks of specific STS histological subtypes are unknown. We quantified the risk of STS histological subtypes after specific types of childhood cancer. Methods: We pooled data from 13 European cohorts, yielding a cohort of 69 460 five-year survivors of childhood cancer. Standardized incidence ratios (SIRs) and absolute excess risks (AERs) were calculated. Results: Overall, 301 STS developed compared with 19 expected (SIR = 15...
November 20, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29165573/an-emerging-role-for-epigenetic-factors-in-relation-to-executive-function
#8
Omar Ibrahim, Heidi G Sutherland, Larisa M Haupt, Lyn R Griffiths
Executive function (EF) includes a range of decision-making and higher-order thinking processes. Although the genetic basis of EF has been studied and reviewed, epigenetic factors that influence EF are an emerging field of interest; here, we summarize the current research. Work relating to different word combinations of 'Executive Function' and 'Epigenetic' was identified through three academic search directories. Inclusion criteria were human populations, EF testing, epigenetic testing or genotyping related to epigenetic regulation...
November 20, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/29160303/the-pnpla3-i148m-variant-is-associated-with-transaminase-elevations-in-type-2-diabetes-patients-treated-with-basal-insulin-peglispro
#9
S Pillai, S Duvvuru, P Bhatnagar, W Foster, M Farmen, S Shankar, C Harris, E Bastyr, B Hoogwerf, A Haupt
Basal insulin peglispro (BIL) is a novel insulin with hepato-preferential action. In phase 3 trials, BIL showed significantly improved glycemic control but higher levels of transaminases (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), triglycerides (TGs) and liver fat content (LFC) compared with insulin glargine (GL). As variants in PNPLA3 (I148M) and TM6SF2 (E167K) are associated with nonalcoholic fatty liver disease, we assessed these variants in type 2 diabetes (T2D) patients randomized to receive BIL (n=1822) or GL (n=1270) in three phase 3 trials...
November 21, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29155942/detergent-based-decellularization-strategy-preserves-macro-and-microstructure-of-heart-valves
#10
Jessica Haupt, Georg Lutter, Stanislav N Gorb, Dan T Simionescu, Derk Frank, Jette Seiler, Alina Paur, Irma Haben
OBJECTIVES: Biological tissue has great potential to function as bioprostheses in patients for heart valve replacement. As these matrices are mainly xenogenic, the immunogenicity needs to be reduced by decellularization steps. Reseeding of bioscaffolds has tremendous potential to prevent calcification upon implantation, so intact microstructure of the material is mandatory. An optimal decellularization protocol of heart valves resulting in adequate preservation of the extracellular architecture has still not been developed...
October 9, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29121687/screening-for-type-1-diabetes-risk-in-newborns-the-freder1k-pilot-study-in-saxony
#11
Angela Hommel, Florian Haupt, Petrina Delivani, Christiane Winkler, Marina Stopsack, Pauline Wimberger, Katharina Nitzsche, Sophie Heinke, Andrea Naeke, Uta Ceglarek, Joachim Thiery, Renate Bergert, Daniel Stadthaus, Katrin Groeger, Georg Heubner, Ursula Schramm, Ullrich Dziambor, Agnes Zirkel, Wieland Kiess, Iris Mueller, Karin Lange, Reinhard Berner, Ezio Bonifacio, Anette-Gabriele Ziegler
An increased risk for type 1 diabetes can be identified using genetic and immune markers. The Freder1k study introduces genetic testing for type 1 diabetes risk within the context of the newborn screening in order to identify newborns with a high risk to develop type 1 diabetes for follow-up testing of early stage type 1 diabetes and for primary prevention trials. Consent for research-based genetic testing of type 1 diabetes risk is obtained with newborn screening. Increased risk is assessed using three single nucleotide polymorphisms for HLA DRB1*03 (DR3), HLA DRB1*04 (DR4), HLA DQB1*0302 (DQ8) alleles, and defined as 1...
November 9, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29105821/accurate-prediction-of-acute-fish-toxicity-of-fragrance-chemicals-with-the-rtgill-w1-cell-assay
#12
Andreas Natsch, Heike Laue, Tina Haupt, Valentin von Niederhäusern, Gordon Sanders
Testing for acute fish toxicity is an integral part of the environmental safety assessment of chemicals. A true replacement of primary fish tissue was recently proposed using cell viability in a fish gill cell line (RTgill-W1) as a means of predicting acute toxicity, showing good predictivity on 35 chemicals. To promote regulatory acceptance, the predictivity and applicability domain of novel tests need to be carefully evaluated on chemicals with existing high quality in vivo data. We applied the RTgill-W1 cell assay to 38 fragrance chemicals with a wide range of physico-chemical properties, a broad range of LC50 values and representing a diverse range of chemistries...
November 4, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29102647/the-transcriptional-landscape-of-radiation-treated-human-prostate-cancer-analysis-of-a-prospective-tissue-cohort
#13
Simon P Keam, Franco Caramia, Cristina Gamell, Piotr J Paul, Gisela Mir Arnau, Paul J Neeson, Scott G Williams, Ygal Haupt
PURPOSE: The resistance of prostate cancer to radiation therapy (RT) is a significant clinical issue and still largely unable to be guided by patient-specific molecular characteristics. The present study describes the gene expression changes induced in response to RT in human prostate tissue obtained from a prospective tissue acquisition study designed for radiobiology research. METHODS AND MATERIALS: A prospective cohort of 5 men with intermediate-risk and clinically localized tumors were treated with high-dose-rate brachytherapy with 2 × 10-Gy fractions...
September 25, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29097342/variable-signaling-activity-by-fop-acvr1-mutations
#14
REVIEW
Julia Haupt, Meiqi Xu, Eileen M Shore
Most patients with fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder of heterotopic ossification, have the same causative mutation in ACVR1, R206H. However, additional mutations within the ACVR1 BMP type I receptor have been identified in a small number of FOP cases, often in patients with disease of lesser or greater severity than occurs with R206H mutations. Genotype-phenotype correlations have been suggested in patients, resulting in classification of FOP mutations based on location within different receptor domains and structural modeling...
October 30, 2017: Bone
https://www.readbyqxmd.com/read/29093615/less-common-etiologies-of-exocrine-pancreatic-insufficiency
#15
REVIEW
Vikesh K Singh, Mark E Haupt, David E Geller, Jerry A Hall, Pedro M Quintana Diez
Exocrine pancreatic insufficiency (EPI), an important cause of maldigestion and malabsorption, results from primary pancreatic diseases or secondarily impaired exocrine pancreatic function. Besides cystic fibrosis and chronic pancreatitis, the most common etiologies of EPI, other causes of EPI include unresectable pancreatic cancer, metabolic diseases (diabetes); impaired hormonal stimulation of exocrine pancreatic secretion by cholecystokinin (CCK); celiac or inflammatory bowel disease (IBD) due to loss of intestinal brush border proteins; and gastrointestinal surgery (asynchrony between motor and secretory functions, impaired enteropancreatic feedback, and inadequate mixing of pancreatic secretions with food)...
October 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29089873/exploiting-heparan-sulfate-proteoglycans-in-human-neurogenesis-controlling-lineage-specification-and-fate
#16
REVIEW
Chieh Yu, Lyn R Griffiths, Larisa M Haupt
Unspecialized, self-renewing stem cells have extraordinary application to regenerative medicine due to their multilineage differentiation potential. Stem cell therapies through replenishing damaged or lost cells in the injured area is an attractive treatment of brain trauma and neurodegenerative neurological disorders. Several stem cell types have neurogenic potential including neural stem cells (NSCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs). Currently, effective use of these cells is limited by our lack of understanding and ability to direct lineage commitment and differentiation of neural lineages...
2017: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/29057301/uncovering-a-novel-pathway-for-p16-silencing-therapeutic-implications-for-lung-cancer
#17
C Gamell, T Gulati, B Solomon, S Haupt, Y Haupt
A key step during onset of most cases of non-small cell lung cancer (NSCLC) is the loss of the tumor suppressor p16(INK4a) (best known as p16), commonly due to promoter hypermethylation. We recently reported a novel regulatory pathway involving E6-associated protein and cell division control protein 6, which provides a methylation-independent mechanism for p16 silencing in patients with a particularly aggressive form of NSCLC.
2017: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/28966548/genome-wide-linkage-and-association-analysis-of-primary-open-angle-glaucoma-endophenotypes-in-the-norfolk-island-isolate
#18
Elizabeth Matovinovic, Pik Fang Kho, Rodney A Lea, Miles C Benton, David A Eccles, Larisa M Haupt, Alex W Hewitt, Justin C Sherwin, David A Mackey, Lyn R Griffiths
PURPOSE: Primary open-angle glaucoma (POAG) refers to a group of heterogeneous diseases involving optic nerve damage. Two well-established risk factors for POAG are elevated intraocular pressure (IOP) and a thinner central corneal thickness (CCT). These endophenotypes exhibit a high degree of heritability across populations. Large-scale genome-wide association studies (GWASs) of outbred populations have robustly implicated several susceptibility gene variants for both IOP and CCT. Despite this progress, a substantial amount of genetic variance remains unexplained...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28954302/risk-of-subsequent-bone-cancers-among-69%C3%A2-460-five-year-survivors-of-childhood-and-adolescent-cancer-in-europe
#19
Miranda M Fidler, Raoul C Reulen, David L Winter, Rodrigue S Allodji, Francesca Bagnasco, Edit Bárdi, Andrea Bautz, Chloe J Bright, Julianne Byrne, Elizabeth A M Feijen, Stanislaw Garwicz, Desiree Grabow, Thorgerdur Gudmundsdottir, Joyeeta Guha, Nadia Haddy, Momcilo Jankovic, Peter Kaatsch, Melanie Kaiser, Rahel Kuonen, Helena Linge, Milena Maule, Franco Merletti, Hilde Øfstaas, Cecile M Ronckers, Roderick Skinner, Jop Teepen, Monica Terenziani, Giao Vu-Bezin, Finn Wesenberg, Thomas Wiebe, Zsuzsanna Jakab, Riccardo Haupt, Päivi Lähteenmäki, Lorna Zadravec Zaletel, Claudia E Kuehni, Jeanette F Winther, Florent de Vathaire, Leontien C Kremer, Lars Hjorth, Michael M Hawkins
Introduction: We investigate the risks of subsequent primary bone cancers after childhood and adolescent cancer in 12 European countries. For the first time, we satisfactorily address the risks beyond 40 years from diagnosis and beyond 40 years of age among all survivors. Methods: This largest-ever assembled cohort comprises 69 460 five-year survivors of cancer diagnosed before age 20 years. Standardized incidence ratios, absolute excess risks, and multivariable-adjusted relative risks and relative excess risks were calculated...
February 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28940721/a-comparative-in-vitro-study-of-different-techniques-for-removal-of-fibre-posts-from-root-canals
#20
Franziska Haupt, Jana Pfitzner, Michael Hülsmann
This study evaluates the effectiveness of different techniques to remove fibre posts from root filled teeth in vitro. One hundred and fifty-three extracted single-rooted teeth were decoronated, root-canal treated and divided into three groups (n = 51). Post spaces were prepared for different types of fibre posts: glass fibre, quartz fibre, carbon fibre. Each group was divided into three subgroups with regard to the post removal technique (n = 17): SonicFlex Endo, long-shaft round bur, DT-Post removal kit. Residual material, loss of dentine, working time and procedural errors were assessed using computed tomography...
September 20, 2017: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
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