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Katie Todd, Gretchen Haupt, Elizabeth Kunz Kollmann, Sarah Pfeifle
Public engagement with science (PES) is an emerging outreach method that builds trust between scientists and public audiences by encouraging two-way conversations and mutual learning about science content and societal values. Building with Biology, a PES initiative focused on synthetic biology, distributed 182 kits with two types of products to informal science education institutions across the United States: 1) hands-on activities for public events, and 2) materials to run public dialogue programs, called forums...
2018: Journal of Microbiology & Biology Education: JMBE
Emily S Tonorezos, Dana Barnea, Richard J Cohn, Monica S Cypriano, Brice C Fresneau, Riccardo Haupt, Lars Hjorth, Yasushi Ishida, Jarmila Kruseova, Claudia E Kuehni, Purna A Kurkure, Thorsten Langer, Paul C Nathan, Jane E Skeen, Roderick Skinner, Nurdan Tacyildiz, Marry M van den Heuvel-Eibrink, Jeanette F Winther, Melissa M Hudson, Kevin C Oeffinger
With improvements in cancer treatment and supportive care, a growing population of survivors of childhood cancer at risk for significant and potentially life-threatening late effects has been identified. To provide a current snapshot of the models of care from countries with varying levels of resources and health care systems, stakeholders in childhood cancer survivorship clinical care and research were identified from 18 countries across five continents. Stakeholders responded to a survey and provided a brief narrative regarding the current state of survivorship care...
June 6, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Wendy van Dorp, Riccardo Haupt, Richard A Anderson, Renee L Mulder, Marry M van den Heuvel-Eibrink, Eline van Dulmen-den Broeder, H Irene Su, Jeanette Falck Winther, Melissa M Hudson, Jennifer M Levine, W Hamish Wallace
Some survivors of childhood, adolescent, and young adult cancer are at increased risk of gonadal dysfunction and adverse pregnancy outcomes. We reviewed currently available literature that evaluated reproductive function and pregnancy outcomes of female cancer survivors diagnosed before the age of 25 years. High-dose alkylating agent chemotherapy and abdominal/pelvic radiotherapy adversely affect gonadal function in a dose-related fashion, with older age at exposure conferring greater risk as a result of the age-related decline in ovarian reserve...
June 6, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
K Cusi, N Sattar, L-E García-Pérez, I Pavo, M Yu, K E Robertson, C A Karanikas, A Haupt
AIMS: To evaluate the effects of dulaglutide vs placebo on liver and glycaemic/metabolic measurements in a population with Type 2 diabetes and in a subgroup with non-alcoholic fatty liver/non-alcoholic steatohepatitis. METHODS: A total of 1499 participants from AWARD-1, AWARD-5, AWARD-8 and AWARD-9 clinical trials were included in this analysis (dulaglutide 1.5 mg, n=971 and placebo, n=528). Thresholds of alanine aminotransferase levels ≥30 IU/l in men and ≥19 IU/l in women were used to determine the subgroup who had non-alcoholic fatty liver/non-alcoholic steatohepatitis...
June 5, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
H Abdallah, A Abramowski, F Aharonian, F Ait Benkhali, E O Angüner, M Arakawa, M Arrieta, P Aubert, M Backes, A Balzer, M Barnard, Y Becherini, J Becker Tjus, D Berge, S Bernhard, K Bernlöhr, R Blackwell, M Böttcher, C Boisson, J Bolmont, S Bonnefoy, P Bordas, J Bregeon, F Brun, P Brun, M Bryan, M Büchele, T Bulik, M Capasso, S Caroff, A Carosi, J Carr, S Casanova, M Cerruti, N Chakraborty, R C G Chaves, A Chen, J Chevalier, S Colafrancesco, B Condon, J Conrad, I D Davids, J Decock, C Deil, J Devin, P deWilt, L Dirson, A Djannati-Ataï, W Domainko, A Donath, L O'C Drury, K Dutson, J Dyks, T Edwards, K Egberts, P Eger, G Emery, J-P Ernenwein, S Eschbach, C Farnier, S Fegan, M V Fernandes, A Fiasson, G Fontaine, A Förster, S Funk, M Füßling, S Gabici, Y A Gallant, T Garrigoux, F Gaté, G Giavitto, B Giebels, D Glawion, J F Glicenstein, D Gottschall, M-H Grondin, J Hahn, M Haupt, J Hawkes, G Heinzelmann, G Henri, G Hermann, J A Hinton, W Hofmann, C Hoischen, T L Holch, M Holler, D Horns, A Ivascenko, H Iwasaki, A Jacholkowska, M Jamrozy, M Janiak, D Jankowsky, F Jankowsky, M Jingo, L Jouvin, I Jung-Richardt, M A Kastendieck, K Katarzyński, M Katsuragawa, U Katz, D Kerszberg, D Khangulyan, B Khélifi, J King, S Klepser, D Klochkov, W Kluźniak, Nu Komin, K Kosack, S Krakau, M Kraus, P P Krüger, H Laffon, G Lamanna, J Lau, J-P Lees, J Lefaucheur, A Lemière, M Lemoine-Goumard, J-P Lenain, E Leser, R Liu, T Lohse, M Lorentz, R López-Coto, I Lypova, D Malyshev, V Marandon, A Marcowith, C Mariaud, R Marx, G Maurin, N Maxted, M Mayer, P J Meintjes, M Meyer, A M W Mitchell, R Moderski, M Mohamed, L Mohrmann, K Morå, E Moulin, T Murach, S Nakashima, M de Naurois, H Ndiyavala, F Niederwanger, J Niemiec, L Oakes, P O'Brien, H Odaka, S Ohm, M Ostrowski, I Oya, M Padovani, M Panter, R D Parsons, N W Pekeur, G Pelletier, C Perennes, P-O Petrucci, B Peyaud, Q Piel, S Pita, V Poireau, H Poon, D Prokhorov, H Prokoph, G Pühlhofer, M Punch, A Quirrenbach, S Raab, R Rauth, A Reimer, O Reimer, M Renaud, R de Los Reyes, F Rieger, L Rinchiuso, C Romoli, G Rowell, B Rudak, C B Rulten, V Sahakian, S Saito, D A Sanchez, A Santangelo, M Sasaki, M Schandri, R Schlickeiser, F Schüssler, A Schulz, U Schwanke, S Schwemmer, M Seglar-Arroyo, M Settimo, A S Seyffert, N Shafi, I Shilon, K Shiningayamwe, R Simoni, H Sol, F Spanier, M Spir-Jacob, Ł Stawarz, R Steenkamp, C Stegmann, C Steppa, I Sushch, T Takahashi, J-P Tavernet, T Tavernier, A M Taylor, R Terrier, L Tibaldo, D Tiziani, M Tluczykont, C Trichard, M Tsirou, N Tsuji, R Tuffs, Y Uchiyama, J van der Walt, C van Eldik, C van Rensburg, B van Soelen, G Vasileiadis, J Veh, C Venter, A Viana, P Vincent, J Vink, F Voisin, H J Völk, T Vuillaume, Z Wadiasingh, S J Wagner, P Wagner, R M Wagner, R White, A Wierzcholska, P Willmann, A Wörnlein, D Wouters, R Yang, D Zaborov, M Zacharias, R Zanin, A A Zdziarski, A Zech, F Zefi, A Ziegler, J Zorn, N Żywucka
Spectral lines are among the most powerful signatures for dark matter (DM) annihilation searches in very-high-energy γ rays. The central region of the Milky Way halo is one of the most promising targets given its large amount of DM and proximity to Earth. We report on a search for a monoenergetic spectral line from self-annihilations of DM particles in the energy range from 300 GeV to 70 TeV using a two-dimensional maximum likelihood method taking advantage of both the spectral and spatial features of the signal versus background...
May 18, 2018: Physical Review Letters
M Haupt, T Kägi, S Hellweg
Life cycle assessment (LCA) is commonly applied to examine the environmental performance of waste management systems. The system boundaries are, however, often limited to either one tonne of material or to specific waste treatments and are, therefore, lacking a systems perspective. Here, a framework is proposed to assess complete waste management systems based on actual waste flows, assessed with a detailed material flow analysis (MFA) in a modular MFA/LCA approach. The transformation of the MFA into a product-process-matrix facilitates a direct link between MFA and LCA, therefore allowing for the assessment of variations in flows...
May 31, 2018: Waste Management
Andreas Natsch, Roger Emter, Tina Haupt, Graham Ellis
Cosmetic regulations prohibit animal testing for the purpose of safety assessment and recent REACH guidance states that the local lymph node assay (LLNA) in mice shall only be conducted if in vitro data cannot give sufficient information for classification and labelling. However, Quantitative Risk Assessment (QRA) for fragrance ingredients requires a NESIL, a dose not expected to cause induction of skin sensitization in humans. In absence of human data, this is derived from the LLNA and it remains a key challenge for risk assessors to derive this value from non-animal data...
June 1, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Simon P Keam, Twishi Gulati, Cristina Gamell, Franco Caramia, Gisela Mir Arnau, Cheng Huang, Ralf B Schittenhelm, Oded Kleifeld, Paul J Neeson, Scott G Williams, Ygal Haupt
Transcriptional dosimetry is an emergent field of radiobiology aimed at developing robust methods for detecting and quantifying absorbed doses using radiation-induced fluctuations in gene expression. A combination of RNA sequencing, array-based and quantitative PCR transcriptomics in cellular, murine and various ex vivo human models has led to a comprehensive description of a fundamental set of genes with demonstrable dosimetric qualities. However, these are yet to be validated in human tissue due to the scarcity of in situ-irradiated source material...
May 30, 2018: Radiation and Environmental Biophysics
Morten Baltzer Houlind, Helle Bach Ølgaard McNulty, Charlotte Treldal, Signe Lindgaard Andersen, Thomas Huneck Haupt, Janne Petersen, Ove Andersen, Lene Juel Kjeldsen
(1) Objective: To assess hospital medication costs and staff time between One-Stop Dispensing (OSD) and the Traditional Medication System (TMS), and to evaluate patient perspectives on OSD. (2) Methods: The study was conducted at Hvidovre Hospital, University of Copenhagen, Denmark in an elective gastric surgery and acute orthopedic surgery department. This study consists of three sub-studies including adult patients able to self-manage medication. In Sub-study 1, staff time used to dispense and administer medication in TMS was assessed...
May 28, 2018: Pharmacy (Basel, Switzerland)
Adam D Lindsay, Edward E Haupt, Chung M Chan, Andre R Spiguel, Mark T Scarborough, Robert A Zlotecki, Parker C Gibbs
Background: The most common site of sarcoma metastasis is the lung. Surgical resection of pulmonary metastases and chemotherapy are treatment options that have been employed, but many patients are poor candidates for these treatments for multiple host or tumor-related reasons. In this group of patients, radiation might provide a less morbid treatment alternative. We sought to evaluate the efficacy of radiotherapy in the treatment of metastatic sarcoma to the lung. Methods: Stereotactic body radiotherapy (SBRT) was used to treat 117 pulmonary metastases in 44 patients...
2018: Sarcoma
Laura Haupt
Two articles in this issue of the Hastings Center Report (May-June 2018) argue that having knowledge of genetic mutations can entail a moral responsibility to rescue others. In the lead article, Madison Kilbride, a philosopher at the Perelman School of Medicine, assigns to the patient, under certain conditions, a task physicians are prohibited from taking on without patient consent: to disclose a finding of a serious, clinically actionable genetic mutation to the patient's relatives who are likely to have the same mutation...
May 2018: Hastings Center Report
Chelsea L Wood, Brian J Zgliczynski, Alison J Haupt, Ana Sofía Guerra, Fiorenza Micheli, Stuart A Sandin
Human impacts on ecosystems can decouple the fundamental ecological relationships that create patterns of diversity in free-living species. Despite the abundance, ubiquity, and ecological importance of parasites, it is unknown whether the same decoupling effects occur for parasitic species. We investigated the influence of fishing on the relationship between host diversity and parasite diversity for parasites of coral reef fishes on three fished and three unfished islands in the central equatorial Pacific. Fishing was associated with a shallowing of the positive host-diversity-parasite-diversity relationship...
May 20, 2018: Global Change Biology
Rachel K Okolicsanyi, Lotta E Oikari, Chieh Yu, Lyn R Griffiths, Larisa M Haupt
Background: Due to their relative ease of isolation and their high ex vivo and in vitro expansive potential, human mesenchymal stem cells (hMSCs) are an attractive candidate for therapeutic applications in the treatment of brain injury and neurological diseases. Heparan sulfate proteoglycans (HSPGs) are a family of ubiquitous proteins involved in a number of vital cellular processes including proliferation and stem cell lineage differentiation. Methods: Following the determination that hMSCs maintain neural potential throughout extended in vitro expansion, we examined the role of HSPGs in mediating the neural potential of hMSCs...
2018: Frontiers in Molecular Neuroscience
Melissa Frick, Tommy Hofmann, Caroline Haupt, Carla Schmidt
The identification of lipids in biological samples is gaining importance. The advent of mass spectrometry-based lipidomics accelerated the field allowing nowadays for identification and quantification of complete lipidomes. However, due to solubility difficulties and varying properties of different lipid classes, sample preparation for lipidomics is still an issue. Of the many lipid classes, phospholipids are the major components of biological membranes. In solution, they spontaneously form lipid vesicles of various structures such as liposomes...
May 8, 2018: Analytical and Bioanalytical Chemistry
Mathias Kahl, Florian Settele, Paul Knick, Ulrich Haupts, Eva Bosse-Doenecke
Protein based binding molecules have a broad applicability from therapeutic to technical use. Monoclonal antibodies represent the major class of this type of agents complemented by innovative approaches using scaffold proteins with tailor-made properties. Various concepts for new formats combining antibody chains or antibody fragments and fusions with other entities have been developed recently. This strategy opens up options to design molecules with biophysical, biochemical and pharmacological characteristics in a broad range while simultaneously addressing several targets or epitopes...
April 25, 2018: Protein Expression and Purification
Marc Bolliger, Andrew R Blight, Edelle C Field-Fote, Kristin Musselman, Serge Rossignol, Dorothy Barthélemy, Laurent Bouyer, Milos R Popovic, Jan M Schwab, Michael L Boninger, Keith E Tansey, Giorgio Scivoletto, Naomi Kleitman, Linda A T Jones, Dany H Gagnon, Sylvie Nadeau, Dirk Haupt, Lea Awai, Chris S Easthope, Björn Zörner, Ruediger Rupp, Dan Lammertse, Armin Curt, John Steeves
STUDY DESIGN: This is a focused review article. OBJECTIVES: To identify important concepts in lower extremity (LE) assessment with a focus on locomotor outcomes and provide guidance on how existing outcome measurement tools may be best used to assess experimental therapies in spinal cord injury (SCI). The emphasis lies on LE outcomes in individuals with complete and incomplete SCI in Phase II-III trials. METHODS: This review includes a summary of topics discussed during a workshop focusing on LE function in SCI, conceptual discussion of corresponding outcome measures and additional focused literature review...
April 27, 2018: Spinal Cord
Axel Haupt, Lisa-Marie Keller, Maximilian Kutter, Dieter Lentz
Herein we report general methods allowing the synthesis of various perfluoroalkylated corannulenes with a specific substitution pattern. Variable temperature NMR spectroscopic investigations revealed dynamic behavior which was analyzed by line shape analysis. The activation parameters of these dynamic processes were determined. For a tetrasubstituted compound it was possible to observe through space scalar coupling. The packing motifs were elucidated by X-ray crystallography, showing that the substitution pattern as well as the size of substituents strongly influence intermolecular Π-stacking...
April 25, 2018: Chemistry: a European Journal
Valeria Davì, Hirokazu Tanimoto, Dmitry Ershov, Armin Haupt, Henry De Belly, Rémi Le Borgne, Etienne Couturier, Arezki Boudaoud, Nicolas Minc
How growing cells cope with size expansion while ensuring mechanical integrity is not known. In walled cells, such as those of microbes and plants, growth and viability are both supported by a thin and rigid encasing cell wall (CW). We deciphered the dynamic mechanisms controlling wall surface assembly during cell growth, using a sub-resolution microscopy approach to monitor CW thickness in live rod-shaped fission yeast cells. We found that polar cell growth yielded wall thinning and that thickness negatively influenced growth...
April 23, 2018: Developmental Cell
M Haupt, E Waser, J C Würmli, S Hellweg
Material recycling often leads to environmental benefits when compared to thermal treatments or landfilling and is therefore positioned in the waste hierarchy as the third priority after waste prevention and reuse. To assess the environmental impacts of recycling and the related substitution of primary material, linear steady-state models of physical flows are typically used. In reality, the environmental burdens of collection and recycling are likely to be a non-linear function of the collection rate. This short communication aims at raising awareness of the non-linear effects in separate collection systems and presents the first non-linear quantitative model for PET bottle recycling...
April 20, 2018: Waste Management
Charmaine E Pollock, Heidi G Sutherland, Bridget H Maher, Rodney A Lea, Larisa M Haupt, Alison Frith, E Anne MacGregor, Lyn R Griffiths
BACKGROUND: In 2016, a large meta-analysis brought the number of susceptibility loci for migraine to 38. While sub-type analysis for migraine without aura (MO) and migraine with aura (MA) found some loci showed specificity to MO, the study did not test the loci with respect to other subtypes of migraine. This study aimed to test the hypothesis that single nucleotide polymorphisms (SNPs) robustly associated with migraine are individually or collectively associated with menstrual migraine (MM)...
April 18, 2018: Journal of Headache and Pain
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