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Charmaine E Pollock, Heidi G Sutherland, Bridget H Maher, Rodney A Lea, Larisa M Haupt, Alison Frith, E Anne MacGregor, Lyn R Griffiths
BACKGROUND: In 2016, a large meta-analysis brought the number of susceptibility loci for migraine to 38. While sub-type analysis for migraine without aura (MO) and migraine with aura (MA) found some loci showed specificity to MO, the study did not test the loci with respect to other subtypes of migraine. This study aimed to test the hypothesis that single nucleotide polymorphisms (SNPs) robustly associated with migraine are individually or collectively associated with menstrual migraine (MM)...
April 18, 2018: Journal of Headache and Pain
M Haupt, M Jänner
BACKGROUND: With the fourth Act on the amendment of pharmaceutical legal and other regulations it became law in Germany from the beginning of 2017 that under certain conditions, pharmaceutical research will be allowed with persons incapable of giving consent, even if this research may only be beneficial to other sufferers of the same disease, i. e. group beneficial research. OBJECTIVE: We conducted a semistructured, non-representative survey among psychiatric patients and their relatives...
April 16, 2018: Der Nervenarzt
Florian Kaiser, Sebastian Bittrich, Sebastian Salentin, Christoph Leberecht, V Joachim Haupt, Sarah Krautwurst, Michael Schroeder, Dirk Labudde
The origin of the machinery that realizes protein biosynthesis in all organisms is still unclear. One key component of this machinery are aminoacyl tRNA synthetases (aaRS), which ligate tRNAs to amino acids while consuming ATP. Sequence analyses revealed that these enzymes can be divided into two complementary classes. Both classes differ significantly on a sequence and structural level, feature different reaction mechanisms, and occur in diverse oligomerization states. The one unifying aspect of both classes is their function of binding ATP...
April 16, 2018: PLoS Computational Biology
Mochao Zhao, Melissa Vandersluis, James Stout, Ulrich Haupts, Matthew Sanders, Renaud Jacquemart
Affinity chromatography is among the most powerful separation techniques, achieving the finest separation with high yields even in the most challenging feed streams. Incorporating affinity chromatography in vaccine purification has long been attempted by researchers to improve unit yield and purity with the secondary goal of reducing the number of downstream process operations. Despite the success in laboratory-scale proof of concept, implementation of this technique in pilot or cGMP manufacturing has rarely been realised due to technical and economic challenges in design and manufacturing of ideal ligands as well as availability of high-productivity chromatography media...
April 4, 2018: Vaccine
Melissa A Rolfes, Alexander J Millman, Pamela Talley, Lina I Elbadawi, Natalie A Kramer, John R Barnes, Lenee Blanton, Jeffrey P Davis, Stefanie Cole, John J Dreisig, Rebecca Garten, Thomas Haupt, Mary Anne Jackson, Anna Kocharian, Daniel Leifer, Ruth Lynfield, Karen Martin, Lisa McHugh, Sara Robinson, George Turabelidze, Lori A Webber, Meghan Pearce Weinberg, David E Wentworth, Lyn Finelli, Michael A Jhung
Background: During the 2014-2015 influenza season in the United States, 256 cases of influenza-associated parotitis were reported from 27 states. We conducted a case-control study and laboratory investigation to further describe this rare clinical manifestation of influenza. Methods: During February 2015-April 2015, we interviewed 50 cases (with parotitis) and 124 ill controls (without parotitis) with laboratory-confirmed influenza; participants resided in 11 states and were matched by age, state, hospital admission status, and specimen collection date...
March 30, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Lina I Elbadawi, Pamela Talley, Melissa A Rolfes, Alexander J Millman, Erik Reisdorf, Natalie A Kramer, John R Barnes, Lenee Blanton, Jaime Christensen, Stefanie Cole, Tonya Danz, John J Dreisig, Rebecca Garten, Thomas Haupt, Beth M Isaac, Mary Anne Jackson, Anna Kocharian, Daniel Leifer, Karen Martin, Lisa McHugh, Rebecca J McNall, Jennifer Palm, Kay W Radford, Sara Robinson, Jennifer B Rosen, Senthilkumar K Sakthivel, Peter Shult, Anna K Strain, George Turabelidze, Lori A Webber, Meghan Pearce Weinberg, David E Wentworth, Brett L Whitaker, Lyn Finelli, Michael A Jhung, Ruth Lynfield, Jeffrey P Davis
Background: During the 2014-2015 US influenza season, 320 cases of non-mumps parotitis (NMP) among residents of 21 states were reported to the Centers for Disease Control and Prevention (CDC). We conducted an epidemiologic and laboratory investigation to determine viral etiologies and clinical features of NMP during this unusually large occurrence. Methods: NMP was defined as acute parotitis or other salivary gland swelling of >2 days duration in a person with a mumps- negative laboratory result...
March 30, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Chantal Mathieu, Stefano Del Prato, Fady T Botros, Vivian T Thieu, Imre Pavo, Nan Jia, Axel Haupt, Chrisanthi A Karanikas, Luis-Emilio García-Pérez
Glucagon-like peptide-1 receptor agonists lower blood glucose in T2D partially through glucose-dependent stimulation of insulin secretion. The aim of the study was to investigate whether or not beta-cell function (measured by HOMA2-%B) at baseline affects the glycaemic response to dulaglutide. Dulaglutide-treated patients from AWARD-1, AWARD-3 and AWARD-6 clinical studies were categorised based on their homeostatic model assessment of beta-cell function (HOMA2-%B) tertiles. Changes in glycaemic measures in response to treatment with once-weekly dulaglutide were evaluated in each HOMA2-%B tertile...
March 30, 2018: Diabetes, Obesity & Metabolism
Armin Haupt, Nicolas Minc
Cells come in a variety of shapes that most often underlie their functions. Regulation of cell morphogenesis implies that there are mechanisms for shape sensing that still remain poorly appreciated. Global and local cell geometry features, such as aspect ratio, size or membrane curvature, may be probed by intracellular modules, such as the cytoskeleton, reaction-diffusion systems or molecular complexes. In multicellular tissues, cell shape emerges as an important means to transduce tissue-inherent chemical and mechanical cues into intracellular organization...
March 26, 2018: Journal of Cell Science
Debora de Oliveira Losnak, Francielle Ramalho Rocha, Barbara Suares de Almeida, Keila Zaniboni Siqueira Batista, Sérgio Luiz Althoff, Josiane Haupt, Luciana Da Silva Ruiz, Laís Anversa, Simone Baldini Lucheis, Laís Moraes Paiz, Maria Rita Donalisio, Virginia Bodelão Richini Pereira
BACKGROUND: Some animals have an important relationship with fungal infections, and searching for pathogens in animal samples may be an opportunity for eco-epidemiological research. Since studies involving wildlife are generally restricted, using samples from road kills is an alternative. OBJECTIVES: The aim of this study was to verify whether pathogenic fungi of public health importance occur in wildlife road kills from Santa Catarina State, Brazil. METHODS: Organ samples (n=1063) from 297 animals were analyzed according to Polymerase Chain Reaction (PCR) using universal primers to detect fungi in general and, subsequently, using primers specific to Paracoccidioides brasiliensis, Histoplasma capsulatum and Cryptococcus spp...
March 25, 2018: Mycoses
Shobini Jayaraman, Donald L Gantz, Christian Haupt, Marcus Fändrich, Olga Gursky
Serum amyloid A action in immune response and deposition in inflammation-linked amyloidosis involve SAA-lipid interactions. We show that SAA sequesters neutral and anionic phospholipids and their hydrolytic products to form nanoparticles, suggesting a synergy with phospholipase A2. The lipid charge and shape affect SAA protection from proteolysis, aggregation and fibrillogenesis.
March 22, 2018: Chemical Communications: Chem Comm
Gabrielle Bradshaw, Robbie R Lualhati, Cassie L Albury, Neven Maksemous, Deidre Roos-Araujo, Robert A Smith, Miles C Benton, David A Eccles, Rod A Lea, Heidi G Sutherland, Larisa M Haupt, Lyn R Griffiths
Background: We investigated the molecular etiology of a young male proband with confirmed immunodeficiency of unknown cause, presenting with recurrent bacterial and Varicella zoster viral infections in childhood and persistent lymphopenia into early adulthood. Aim: To identify causative functional genetic variants related to an undiagnosed primary immunodeficiency. Method: Whole genome microarray copy number variant (CNV) analysis was performed on the proband followed by whole exome sequencing (WES) and trio analysis of the proband and family members...
2018: Frontiers in Immunology
Laurits J Holm, Martin Haupt-Jorgensen, Jesper Larsen, Jano D Giacobini, Mesut Bilgin, Karsten Buschard
Sphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating insulin folding and controlling apoptosis. Sphingolipid biosynthesis begins with the condensation of L-serine and palmitoyl-CoA. Here we tested the effect of L-serine supplementation on autoimmune diabetes development and blood glucose homeostasis in female NOD mice. We found that continuous supplementation of L-serine reduces diabetes incidence and insulitis score. In addition, L-serine treated mice had an improved glucose tolerance test, reduced HOMA-IR, and reduced blood glucose levels...
2018: PloS One
Lucia Rigamonti, Monia Niero, Melanie Haupt, Mario Grosso, Jáchym Judl
No abstract text is available yet for this article.
March 9, 2018: Waste Management
Simon P Keam, Twishi Gulati, Cristina Gamell, Franco Caramia, Cheng Huang, Ralf B Schittenhelm, Oded Kleifeld, Paul J Neeson, Ygal Haupt, Scott G Williams
INTRODUCTION: The development of radioresistance in prostate cancer (PCa) is an important clinical issue and is still largely uninformed by personalized molecular characteristics. The aim of this study was to establish a platform that describes the early oncoproteomic response of human prostate tissue to radiation therapy (RT) using a prospective human tissue cohort. METHODS: Fresh and fixed transperineal biopsies from eight men with clinically localized tumors were taken prior to and 14 days following a single fraction of high-dose-rate brachytherapy...
March 9, 2018: Prostate
Pia Flossdorf, Walter F Haupt, Anna Brunn, Martina Deckert, Gereon R Fink, Helmar C Lehmann, Gilbert Wunderlich
BACKGROUND: Small fiber neuropathy (SFN) is a challenging subtype of peripheral neuropathies. Once the diagnosis has been established, there is an uncertainty how SFN may progress, whether larger fibers will become involved over time, whether quality of life may be compromised, or whether repeated diagnostic workup in patients with unknown underlying cause may increase the yield of treatable causes of SFN. METHODS: We evaluated 16 patients with documented long-time course of idiopathic SFN...
March 8, 2018: European Neurology
Franziska Haupt, M Hülsmann
OBJECTIVES: To assess the consistency of electronic determination of endodontic working length obtained from four identical electronic root canal length measurement devices (ERCLMD) from five different types of ERCLMD each under various in vitro conditions. MATERIALS AND METHODS: Eight extracted teeth, seven single-rooted teeth, and one molar were accessed. Root length was measured and instruments were inserted and fixed with the tip placed beyond and short of the apical constriction, in roots with an artificial perforation or an open apex...
March 7, 2018: Clinical Oral Investigations
Desiree Grabow, Melanie Kaiser, Lars Hjorth, Julianne Byrne, Daniela Alessi, Rodrigue S Allodji, Francesca Bagnasco, Edit Bárdi, Andrea Bautz, Chloe J Bright, Florent de Vathaire, Elizabeth A M Feijen, Stanislaw Garwicz, Oskar Hagberg, Riccardo Haupt, Mike M Hawkins, Zsuzsanna Jakab, Leontien C M Kremer, Claudia E Kuehni, Rahel Kuonen, Päivi Maria Lähteenmäki, Raoul C Reulen, Cécile M Ronckers, Carlotta Sacerdote, Giao Vu-Bezin, Finn Wesenberg, Thomas Wiebe, David L Winter, Jeanette Falck Winther, Lorna Zadravec Zaletel, Peter Kaatsch
Childhood cancer survivors face risks from a variety of late effects, including cardiac events, second cancers, and late mortality. The aim of the pan-European PanCare Childhood and Adolescent Cancer Survivor Care and Follow-Up Studies (PanCareSurFup) Consortium was to collect data on incidence and risk factors for these late effects among childhood cancer survivors in Europe. This paper describes the methodology of the data collection for the overall PanCareSurFup cohort and the outcome-related cohorts. In PanCareSurFup 13 data providers from 12 countries delivered data to the data centre in Mainz...
March 2, 2018: European Journal of Epidemiology
Paul Dunn, Cassie L Albury, Neven Maksemous, Miles C Benton, Heidi G Sutherland, Robert A Smith, Larisa M Haupt, Lyn R Griffiths
Epilepsy is a neurological disorder characterized by an increased predisposition for seizures. Although this definition suggests that it is a single disorder, epilepsy encompasses a group of disorders with diverse aetiologies and outcomes. A genetic basis for epilepsy syndromes has been postulated for several decades, with several mutations in specific genes identified that have increased our understanding of the genetic influence on epilepsies. With 70-80% of epilepsy cases identified to have a genetic cause, there are now hundreds of genes identified to be associated with epilepsy syndromes which can be analyzed using next generation sequencing (NGS) techniques such as targeted gene panels, whole exome sequencing (WES) and whole genome sequencing (WGS)...
2018: Frontiers in Genetics
Twishi Gulati, Cheng Huang, Franco Caramia, Dinesh Raghu, Piotr Jan Paul, Robert J A Goode, Simon Paul Keam, Scott G Williams, Sue Haupt, Oded Kleifeld, Ralf B Schittenhelm, Cristina Gamell, Ygal Haupt
Prostate cancer is a common cause of cancer-related death in men. E6AP (E6-Associated Protein), an E3 ubiquitin ligase and a transcription cofactor, is elevated in a subset of prostate cancer patients. Genetic manipulations of E6AP in prostate cancer cells expose a role of E6AP in promoting growth and survival of prostate cancer cells in vitro and in vivo. However, the effect of E6AP on prostate cancer cells is broad and it cannot be explained fully by previously identified tumour suppressor targets of E6AP, promyelocytic leukemia protein and p27...
February 20, 2018: Molecular & Cellular Proteomics: MCP
Kristina S Boye, Fady T Botros, Axel Haupt, Brad Woodward, Maureen J Lage
INTRODUCTION: The study characterizes the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in patients with type 2 diabetes (T2D) with and without renal impairment and examines the effects of such use on the clinical outcomes of estimated glomerular filtration rate (eGFR) and glycated hemoglobin (A1c). METHODS: Data from the Practice Fusion electronic health records database from 1 January 2012 through 30 April 2015 were used. Adults with T2D who received serum creatinine laboratory tests and initiated therapy with a GLP-1 RA (N = 3225) or other glucose-lowering agent (GLA) (N = 37,074) were included in the analysis...
February 19, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
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