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https://www.readbyqxmd.com/read/28645442/spinal-canal-involvement-in-neuroblastoma
#1
Toby Trahair, Stefania Sorrentino, Susan J Russell, Hugo Sampaio, Laurent Selek, Dominique Plantaz, Claire Freycon, Thorsten Simon, Kathelijne Kraal, Maja Beck-Popovic, Riccardo Haupt, Shifra Ash, Bruno De Bernardi
No abstract text is available yet for this article.
June 20, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28637682/cellular-mechanism-of-fibril-formation-from-serum-amyloid-a1-protein
#2
Stephanie Claus, Katrin Meinhardt, Tobias Aumüller, Ioana Puscalau-Girtu, Julia Linder, Christian Haupt, Paul Walther, Tatiana Syrovets, Thomas Simmet, Marcus Fändrich
Serum amyloid A1 (SAA1) is an apolipoprotein that binds to the high-density lipoprotein (HDL) fraction of the serum and constitutes the fibril precursor protein in systemic AA amyloidosis. We here show that HDL binding blocks fibril formation from soluble SAA1 protein, whereas internalization into mononuclear phagocytes leads to the formation of amyloid. SAA1 aggregation in the cell model disturbs the integrity of vesicular membranes and leads to lysosomal leakage and apoptotic death. The formed amyloid becomes deposited outside the cell where it can seed the fibrillation of extracellular SAA1...
June 21, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28631600/inhibition-of-carbonic-anhydrase-ix-by-ureidosulfonamide-inhibitor-u104-reduces-prostate-cancer-cell-growth-but-does-not-modulate-daunorubicin-or-cisplatin-cytotoxicity
#3
Anne Riemann, Antje Güttler, Verena Haupt, Henri Wichmann, Sarah Reime, Matthias Bache, Dirk Vordermark, Oliver Thews
Carbonic anhydrase IX has emerged as a promising target for cancer therapy. It is highly up-regulated in hypoxic regions and mediates pH regulation critical for tumor cell survival as well as extracellular acidification of the tumor microenvironment which promotes tumor aggressiveness via various mechanisms, such as augmenting metastatic potential. Therefore, the aim of this study was to analyze the complex interdependency between CA IX and the tumor microenvironment in prostate tumor cells in concern of potential therapeutic implications...
June 19, 2017: Oncology Research
https://www.readbyqxmd.com/read/28614005/prevalence-and-correlates-of-adherence-in-children-and-adolescents-treated-with-growth-hormone-a-multicenter-italian-study
#4
Francesca Bagnasco, Natascia Di Iorgi, Andrea Roveda, Annalisa Gallizia, Riccardo Haupt, Mohamad Maghnie
OBJECTIVE: to evaluate the self-reported prevalence of poor adherence to rhGH therapy in a large, representative sample of Italian children and adolescents and to assess treatment and patient level correlates of poor adherence. METHODS: The study was conducted in 46 pediatric centers throughout Italy. A questionnaire was administered to consecutive children/adolescents treated with rhGH or their parents. Eligible patients were represented by subjects aged between 6 and 16 years, of both sexes, on treatment with rhGH for at least 6 months...
June 14, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28609944/review-of-the-i-priocnemis-i-i-hyalinata-i-species-group-hymenoptera-pompilidae-with-description-of-a-new-species-from-china
#5
Valery M Loktionov, Arkady S Lelej, Zai-Fu Xu
Eight species in the Priocnemis hyalinata species-group are reviewed. The species-group is recorded from Oriental Region for the first time, and one new species, Priocnemis (Priocnemis) yunnanensis Loktionov, Lelej & Xu, sp. nov. (China: Yunnan) is described and illustrated. The lectotype of Salius (Priocnemis) unicolor Gussakovskij is designated. The distribution of P. (P.) hyalinata (Fabricius), P. (P.) fennica Haupt and P. (P.) unicolor (Gussakovskij) is clarified and enlarged within Russia. Keys to species for males and females are given...
April 20, 2017: Zootaxa
https://www.readbyqxmd.com/read/28582490/impact-of-minimally-invasive-extracorporeal-circuits-on-octogenarians-undergoing-coronary-artery-bypass-grafting-have-we-been-looking-in-the-wrong-direction-%C3%A2
#6
Aschraf El-Essawi, Ingo Breitenbach, Benjamin Haupt, Rene Brouwer, Hassina Baraki, Wolfgang Harringer
OBJECTIVES: Minimally invasive extracorporeal circuits (MiECCs) aim at the preservation of physiologic reserves, the impact of which is expected to be most evident in patients in whom these are depleted. In this context, octogenarians present a subpopulation of specific interest. METHODS: Based on the type of the utilized ECC, we performed a retrospective comparison between all octogenarians ( n  = 324) who received a primary coronary artery bypass in our institution from 2003 until 2010...
June 3, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28560240/mesoscale-brain-explorer-a-flexible-python-based-image-analysis-and-visualization-tool
#7
Dirk Haupt, Matthieu P Vanni, Federico Bolanos, Catalin Mitelut, Jeffrey M LeDue, Tim H Murphy
Imaging of mesoscale brain activity is used to map interactions between brain regions. This work has benefited from the pioneering studies of Grinvald et al., who employed optical methods to image brain function by exploiting the properties of intrinsic optical signals and small molecule voltage-sensitive dyes. Mesoscale interareal brain imaging techniques have been advanced by cell targeted and selective recombinant indicators of neuronal activity. Spontaneous resting state activity is often collected during mesoscale imaging to provide the basis for mapping of connectivity relationships using correlation...
July 2017: Neurophotonics
https://www.readbyqxmd.com/read/28559802/a-creb1-gene-polymorphism-rs2253206-is-associated-with-prospective-memory-in-a-healthy-cohort
#8
Nesli Avgan, Heidi G Sutherland, Rodney A Lea, Lauren K Spriggens, Larisa M Haupt, David H K Shum, Lyn R Griffiths
Prospective memory (PM) is generally defined as remembering to perform intended actions in the future and is important for functioning in daily life. Cyclic adenosine monophosphate (cAMP) responsive element binding protein 1 (CREB1) plays an important role in cognitive functions. In this study, we hypothesized that genetic variation in the CREB1 gene is associated with PM. We genotyped a CREB1 promoter polymorphism rs2253206 and tested it for association with PM in 619 healthy subjects. PM performance was measured using the Prospective and Retrospective Memory Questionnaire (PRMQ), the Comprehensive Assessment of Prospective Memory (CAPM), and the Memory for Intentions Screening Test (MIST)...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28544119/common-fibril-structures-imply-systemically-conserved-protein-misfolding-pathways-in%C3%A2-vivo
#9
Karthikeyan Annamalai, Falk Liberta, Marie-Theres Vielberg, William Close, Hauke Lilie, Karl-Heinz Gührs, Angelika Schierhorn, Rolf Koehler, Andreas Schmidt, Christian Haupt, Ute Hegenbart, Stefan Schönland, Matthias Schmidt, Michael Groll, Marcus Fändrich
Systemic amyloidosis is caused by the misfolding of a circulating amyloid precursor protein and the deposition of amyloid fibrils in multiple organs. Chemical and biophysical analysis of amyloid fibrils from human AL and murine AA amyloidosis reveal the same fibril morphologies in different tissues or organs of one patient or diseased animal. The observed structural similarities concerned the fibril morphology, the fibril protein primary and secondary structures, the presence of post-translational modifications and, in case of the AL fibrils, the partially folded characteristics of the polypeptide chain within the fibril...
May 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28477016/e6ap-promotes-prostate-cancer-by-reducing-p27-expression
#10
Dinesh Raghu, Piotr Jan Paul, Twishi Gulati, Siddhartha Deb, Christine Khoo, Andrea Russo, Enzo Gallo, Giovanni Blandino, Ai-Leen Chan, Elena Takano, Shahneen K Sandhu, Stephen B Fox, Scott Williams, Sue Haupt, Cristina Gamell, Ygal Haupt
Prostate cancer (PC) is the most common cancer in men. Elevated levels of E3 ligase, E6-Associated Protein (E6AP) were previously linked to PC, consistent with increased protein expression in a subset of PC patients. In cancers, irregular E3 ligase activity drives proteasomal degradation of tumor suppressor proteins. Accordingly, E3 ligase inhibitors define a rational therapy to restore tumor suppression. The relevant tumor suppressors targeted by E6AP in PC are yet to be fully identified. In this study we show that p27, a key cell cycle regulator, is a target of E6AP in PC...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28476197/road-traffic-pollution-and-childhood-leukemia-a-nationwide-case-control-study-in-italy
#11
Corrado Magnani, Alessandra Ranucci, Chiara Badaloni, Giulia Cesaroni, Daniela Ferrante, Lucia Miligi, Stefano Mattioli, Roberto Rondelli, Luigi Bisanti, Paola Zambon, Santina Cannizzaro, Paola Michelozzi, Pierluigi Cocco, Egidio Celentano, Giorgio Assennato, Domenico Franco Merlo, Paola Mosciatti, Liliana Minelli, Marina Cuttini, Maria Valeria Torregrossa, Susanna Lagorio, Riccardo Haupt, Francesco Forastiere
BACKGROUND: The association of childhood leukemia with traffic pollution was considered in a number of studies from 1989 onwards, with results not entirely consistent and little information regarding subtypes. AIM OF THE STUDY: We used the data of the Italian SETIL case-control on childhood leukemia to explore the risk by leukemia subtypes associated to exposure to vehicular traffic. METHODS: We included in the analyses 648 cases of childhood leukemia (565 Acute lymphoblastic-ALL and 80 Acute non lymphoblastic-AnLL) and 980 controls...
November 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/28453640/pioneering-topological-methods-for-network-based-drug-target-prediction-by-exploiting-a-brain-network-self-organization-theory
#12
Claudio Durán, Simone Daminelli, Josephine M Thomas, V Joachim Haupt, Michael Schroeder, Carlo Vittorio Cannistraci
The bipartite network representation of the drug-target interactions (DTIs) in a biosystem enhances understanding of the drugs' multifaceted action modes, suggests therapeutic switching for approved drugs and unveils possible side effects. As experimental testing of DTIs is costly and time-consuming, computational predictors are of great aid. Here, for the first time, state-of-the-art DTI supervised predictors custom-made in network biology were compared-using standard and innovative validation frameworks-with unsupervised pure topological-based models designed for general-purpose link prediction in bipartite networks...
April 26, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28438470/how-inflammation-underlies-physical-and-organ-function-in-acutely-admitted-older-medical-patients
#13
Henrik Hedegaard Klausen, Ann Christine Bodilsen, Janne Petersen, Thomas Bandholm, Thomas Haupt, Ditte Maria Sivertsen, Ove Andersen
OBJECTIVES: To investigate whether systemic inflammation in acutely admitted older medical patients (age >65 years) is associated with physical performance and organ dysfunction. Organ dysfunction´s association with physical performance, and whether these associations are mediated by systemic inflammation, was also investigated. METHODS: A cross-sectional study in an Emergency Department. Physical performance was assessed by handgrip strength and de Morton Mobility Index (DEMMI), and organ dysfunction by FI-OutRef, the number of standard blood tests outside the reference range...
April 22, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28435386/more-new-records-of-spider-wasps-from-colombia-hymenoptera-pompilidae
#14
Cecilia Waichert, Fernando Fernández, Valentina Castro-Huertas, Juanita Rodriguez, James P Pitts
Aporinellus Banks, Austrochares Banks and Dicranoplius Haupt are new generic records for Colombia, as well as the species Dipogon ariel Banks, Evagetes peruana Banks, and Euplaniceps notabilis (Smith). Five new combinations are formally endorsed: Aimatocare argentinica (Banks), comb. n.; Aimatocare longula (Banks), comb. n.; Aimatocare imitator (Evans), comb. n.; Aimatocare impensa (Evans), comb. n.; Aimatocare vitrea (Fox), comb. n. Although these names have been used in Pompilidae, no formal nomenclatural act had been proposed...
2017: ZooKeys
https://www.readbyqxmd.com/read/28417532/non-alcoholic-fatty-liver-disease-nafld-prevalence-and-its-metabolic-associations-in-patients-with-type-1-diabetes-and-type-2-diabetes
#15
Kenneth Cusi, Arun J Sanyal, Shuyu Zhang, Mark L Hartman, Juliana M Bue-Valleskey, Byron J Hoogwerf, Axel Haupt
We investigated non-alcoholic fatty liver disease (NAFLD) prevalence and its metabolic associations in patients with type 1 diabetes (T1D), and in insulin-naïve and insulin-treated patients with type 2 diabetes (T2D). Baseline data from patients who had liver fat content (LFC) evaluated by magnetic resonance imaging in 4 phase 3 studies of basal insulin peglispro (BIL) were analyzed. Associations of NAFLD with clinical characteristics, glycemic control and diabetes therapy were evaluated. The prevalence of NAFLD (defined as LFC ≥6%) was low in T1D (8...
April 17, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28411635/guide-to-the-preparation-of-molecularly-imprinted-polymer-nanoparticles-for-protein-recognition-by-solid-phase-synthesis
#16
Jingjing Xu, Paulina X Medina-Rangel, Karsten Haupt, Bernadette Tse Sum Bui
Molecularly imprinted polymers (MIPs) are synthetic antibody mimics possessing specific cavities designed for a target molecule. Nowadays, molecular imprinting of proteins still remains a challenge as the generation of selective imprinted cavities is extremely difficult, due to their flexible structure and the presence of a multitude of functional sites. To overcome this difficulty, we propose a solid-phase synthesis strategy to prepare MIPs specific for any protein that can be immobilized in an oriented way on a solid support...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28389699/ion-channelopathies-and-migraine-pathogenesis
#17
REVIEW
Cassie L Albury, Shani Stuart, Larisa M Haupt, Lyn R Griffiths
Migraine is a common neurological disorder that affects approximately 12-20% of the general adult population. Migraine pathogenesis is complex and not wholly understood. Molecular genetic investigations, imaging and biochemical studies, have unveiled a number of interconnected neurological pathways which seem to have a cause and effect component integral to its cause. Much weight of migraine attack initiation can be placed on the initial trigger and the pathways involved in its neuronal counter reaction. Ion channels play a large role in the generation, portrayal and mitigation of the brains response to external triggers...
April 7, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28389095/chemometric-evaluation-of-the-combined-effect-of-temperature-pressure-and-co-solvent-fractions-on-the-chiral-separation-of-basic-pharmaceuticals-using-actual-vs-set-operational-conditions
#18
Erik Forss, Dan Haupt, Olle Stålberg, Martin Enmark, Jörgen Samuelsson, Torgny Fornstedt
The need to determine the actual operational conditions, instead of merely using the set operational conditions, was investigated for in packed supercritical fluid chromatography (SFC) by design of experiments (DoE) using a most important type of compounds, pharmaceutical basics, as models. The actual values of temperature, pressure, and methanol levels were recorded and calculated from external sensors, while the responses in the DoE were the retention factors and selectivity. A Kromasil CelluCoat column was used as the stationary phase, carbon dioxide containing varying methanol contents as the mobile phase, and the six racemates of alprenolol, atenolol, metoprolol, propranolol, clenbuterol, and mianserin were selected as model solutes...
March 28, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28386569/corrigendum-to-large-gliadin-peptides-detected-in-the-pancreas-of-nod-and-healthy-mice-following-oral-administration
#19
Susanne W Bruun, Knud Josefsen, Julia T Tanassi, Aleš Marek, Martin H F Pedersen, Ulrik Sidenius, Martin Haupt-Jorgensen, Julie C Antvorskov, Jesper Larsen, Niels H Heegaard, Karsten Buschard
[This corrects the article DOI: 10.1155/2016/2424306.].
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28374101/major-and-minor-complications-after-anterior-rectal-resection-for-deeply-infiltrating-endometriosis
#20
Stefan P Renner, Hermann Kessler, Nalan Topal, Kim Proske, Werner Adler, Stefanie Burghaus, Werner Haupt, Matthias W Beckmann, Johannes Lermann
PURPOSE: The aim of the present study was to analyze major and minor complications-including long-term impairment of intestinal, bladder, and sexual function-following surgery for deeply infiltrating endometriosis using anterior rectal resection. METHODS: Patients who had undergone anterior rectal resection due to endometriosis between 2001 and 2011 were included (n = 113). Clinical and surgical data, as well as minor and major complications, were recorded. A questionnaire was sent to the patients and also to a healthy control group (n = 100)...
April 3, 2017: Archives of Gynecology and Obstetrics
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