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https://www.readbyqxmd.com/read/29426500/competitive-fluorescent-pseudo-immunoassay-exploiting-molecularly-imprinted-polymers-for-the-detection-of-biogenic-amines-in-fish-matrix
#1
Leena Mattsson, Jingjing Xu, Claudia Preininger, Bernadette Tse Sum Bui, Karsten Haupt
We developed a competitive fluorescent molecularly imprinted polymer (MIP) assay to detect biogenic amines in fish samples. MIPs synthesized by precipitation polymerization using histamine as template were used in a batch binding assay analogous to competitive fluoroimmunoassays. Introducing a complex sample matrix, such as fish extract, into the assay changes the environment and the binding conditions, therefore the importance of the sample preparation is extensively discussed. Several extraction and purification methods for fish were comprehensively studied, and an optimal clean-up procedure for fish samples using liquid-liquid extraction was developed...
May 1, 2018: Talanta
https://www.readbyqxmd.com/read/29392873/gluten-free-diet-exclusively-during-pregnancy-alleviates-the-signs-of-diabetes-and-celiac-disease-in-nod-mouse-offspring
#2
Martin Haupt-Jorgensen, Jesper Larsen, Knud Josefsen, Tina Z Jørgensen, Julie Christine Antvorskov, Axel K Hansen, Karsten Buschard
BACKGROUND: Gluten-free (GF) diet during pregnancy ameliorates autoimmune diabetes in non-obese diabetic (NOD) mouse offspring. Due to comorbidity of celiac disease in type 1 diabetes, we hypothesized that GF diet in utero alleviates the humoral and histopathological signs of celiac disease in NOD mice. We aimed to establish the mechanisms behind the diabetes-protective effect of GF diet in utero. METHODS: Breeding pairs of NOD mice were fed a GF or gluten-containing standard (STD) diet until parturition...
February 2, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29391054/supar-is-associated-with-risk-of-future-acute-surgery-and-post-operative-mortality-in-acutely-admitted-medical-patients
#3
Jeppe Meyer, Morten Alstrup, Line J H Rasmussen, Martin Schultz, Steen Ladelund, Thomas H Haupt, Jens Tingleff, Kasper Iversen, Jesper Eugen-Olsen
BACKGROUND: Acutely admitted medical patients are often fragile and in risk of future surgery. The biomarker soluble urokinase plasminogen activator receptor (suPAR) is a predictor of readmission and mortality in the acute care setting. We aimed to investigate if suPAR also predicts acute surgery, which is associated with higher mortality than elective surgery, and if it predicts post-operative mortality. METHODS: A retrospective registry-based cohort study of 17,312 patients admitted to an acute medical unit in Denmark, from 18 November 2013 until 30 September 2015...
February 1, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29363379/acute-exacerbations-after-decades-of-non-active-chronic-multiple-sclerosis
#4
Michael R Haupts, Petra Spill-Askeridis, Marius Humpert, Dietmar Seidel, Hans-Peter Hartung
No abstract text is available yet for this article.
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29299913/tracking-hyaluronan-molecularly-imprinted-polymer-coated-carbon-dots-for-cancer-cell-targeting-and-imaging
#5
Bilal Demir, Michael Lemberger, Maria Panagiotopoulou, Paulina Medina-Rangel, Suna Timur, Thomas Hirsch, Bernadette Tse Sum Bui, Joachim Wegener, Karsten Haupt
War against cancer constantly requires new affinity tools to selectively detect, localize and quantify biomarkers for diagnosis or prognosis. Herein, carbon nanodots (CDs), an emerging class of fluorescent nanomaterials, coupled with molecularly imprinted polymers (MIPs), are employed as a biocompatible optical imaging tool for probing cancer biomarkers. First, N-doped CDs were prepared by hydrothermal synthesis using starch as carbon source, and L-tryptophan as nitrogen atom provider to achieve a high quantum yield of (25...
January 4, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29290925/new-insights-on-the-regulation-of-ink4-arf-locus-expression
#6
EDITORIAL
Cristina Gamell, Doron Ginsberg, Sue Haupt, Ygal Haupt
No abstract text is available yet for this article.
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29286378/combining-chemical-cross-linking-and-mass-spectrometry-of-intact-protein-complexes-to-study-the-architecture-of-multi-subunit-protein-assemblies
#7
Caroline Haupt, Tommy Hofmann, Sabine Wittig, Susann Kostmann, Argyris Politis, Carla Schmidt
Proteins interact with their ligands to form active and dynamic assemblies which carry out various cellular functions. Elucidating these interactions is therefore fundamental for the understanding of cellular processes. However, many protein complexes are dynamic assemblies and are not accessible by conventional structural techniques. Mass spectrometry contributes to the structural investigation of these assemblies, and particularly the combination of various mass spectrometric techniques delivers valuable insights into their structural arrangement...
November 28, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29276410/clinical-course-of-nonalcoholic-fatty-liver-disease-an-assessment-of-severity-progression-and-outcomes
#8
Jason C Simeone, Jay P Bae, Byron J Hoogwerf, Qian Li, Axel Haupt, Ayad K Ali, Marilyn K Boardman, Beth L Nordstrom
Purpose: To identify the characteristics and initial disease severity of patients with nonalcoholic fatty liver disease (NAFLD) and assess incidence and risk factors for disease progression in a retrospective study. Methods: Patients ≥18 years of age without alcoholism or other liver diseases (eg, hepatitis B/C) were selected from Geisinger Health System electronic medical record data from 2004 to 2015. Initial disease stage was stratified into uncomplicated NAFLD, advanced fibrosis, cirrhosis, hepatocellular carcinoma (HCC), and liver transplant using clinical biomarkers, diagnosis, and procedure codes...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/29250320/p53-at-the-start-of-the-21st-century-lessons-from-elephants
#9
REVIEW
Sue Haupt, Ygal Haupt
Crucial, natural protection against tumour onset in humans is orchestrated by the dynamic protein p53. The best-characterised functions of p53 relate to its cellular stress responses. In this review, we explore emerging insights into p53 activities and their functional consequences. We compare p53 in humans and elephants, in search of salient features of cancer protection.
2017: F1000Research
https://www.readbyqxmd.com/read/29232700/sygl-1-and-lst-1-link-niche-signaling-to-puf-rna-repression-for-stem-cell-maintenance-in-caenorhabditis-elegans
#10
Heaji Shin, Kimberly A Haupt, Aaron M Kershner, Peggy Kroll-Conner, Marvin Wickens, Judith Kimble
Central questions in regenerative biology include how stem cells are maintained and how they transition from self-renewal to differentiation. Germline stem cells (GSCs) in Caenorhabditis elegans provide a tractable in vivo model to address these questions. In this system, Notch signaling and PUF RNA binding proteins, FBF-1 and FBF-2 (collectively FBF), maintain a pool of GSCs in a naïve state. An open question has been how Notch signaling modulates FBF activity to promote stem cell self-renewal. Here we report that two Notch targets, SYGL-1 and LST-1, link niche signaling to FBF...
December 12, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29232068/dynamic-evaluation-of-a-trilobal-capillary-channeled-polymer-fiber-shape-for-reversed-phase-protein-separations-and-comparison-to-the-eight-channeled-form
#11
Lei Wang, Kathryn A Stevens, Paul Haupt-Renaud, R Kenneth Marcus
A new, trilobal shaped capillary-channeled polymer fiber is under development to address the issues of poor A-term performance of the previous eight-channeled form. The trilobal geometry should provide better packing homogeneity due to the fewer potential orientations of the symmetric fiber geometry. Comparisons of separation efficiency and peak shape were made between the two fiber shapes through several dynamic parameters. Column hydrodynamics were investigated with two marker compounds, uracil and bovine serum albumin, with van Deemter plots of those two compounds revealing differences in the packing qualities between the different fiber shapes...
December 12, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29223216/proud-and-grateful-to-be-a-nurse-and-an-educator
#12
Rachael Haupt-Harrington
No abstract text is available yet for this article.
December 2017: Nursing for Women's Health
https://www.readbyqxmd.com/read/29215094/expression-qtl-analysis-of-glaucoma-endophenotypes-in-the-norfolk-island-isolate-provides-evidence-that-immune-related-genes-are-associated-with-optic-disc-size
#13
Pik Fang Kho, Rodney A Lea, Miles C Benton, David Eccles, Larisa M Haupt, Alex W Hewitt, Justin C Sherwin, David A Mackey, Lyn R Griffiths
Primary open-angle glaucoma (POAG) is influenced by both genetic and environmental factors. Despite significant progress in identifying genetic variants associated with POAG, there remains a substantial amount of unexplained heritability. Study design features that may enhance knowledge of the genetic architecture include focusing on multiple quantitative traits related to ocular disorders (i.e. endophenotypes), targeting genetic variants that directly influence gene expression (i.e. cis-eQTLs) and utilising genetically isolated populations to reduce genetic and environmental noise and thus enhance association signals...
November 16, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/29177076/effectiveness-and-efficiency-of-different-weight-machine-based-strength-training-programmes-for-patients-with-hip-or-knee-osteoarthritis-a-protocol-for-a-quasi-experimental-controlled-study-in-the-context-of-health-services-research
#14
Inga Krauss, Gerhard Müller, Benjamin Steinhilber, Georg Haupt, Pia Janssen, Peter Martus
Introduction: Osteoarthritis is a chronic musculoskeletal disease with a major impact on the individual and the healthcare system. As there is no cure, therapy aims for symptom release and reduction of disease progression. Physical exercises have been defined as a core treatment for osteoarthritis. However, research questions related to dose response, sustainability of effects, economic efficiency and safety are still open and will be evaluated in this trial, investigating a progressive weight machine-based strength training...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29167192/cytokeratin-18-and-enhanced-liver-fibrosis-scores-in-type-1-and-type-2-diabetes-and-effects-of-two-different-insulins
#15
Arun Sanyal, Kenneth Cusi, Mark L Hartman, Shuyu Zhang, Edward J Bastyr, Juliana M Bue-Valleskey, Annette M Chang, Axel Haupt, Scott J Jacober, Robert J Konrad, Qianyi Zhang, Byron J Hoogwerf
Data on cytokeratin-18 (K-18) and enhanced liver fibrosis (ELF) score in insulin-treated diabetes patients with non-alcoholic fatty liver disease (NAFLD) are limited. This study analyzed phase III data comparing basal insulin peglispro (BIL) and insulin glargine in type 1 (T1D), and type 2 diabetes (T2D) (insulin-naïve and insulin-treated). Alanine aminotransferase (ALT), K-18, ELF scores and liver fat content (LFC), measured by MRI, were obtained longitudinally. Baseline K-18 (U/L) was higher in T2D (range: 207‒247) than T1D (range: 148‒183), correlated with ALT in all populations (r (range) 0...
November 21, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29165710/risk-of-soft-tissue-sarcoma-among-69-460-five-year-survivors-of-childhood-cancer-in-europe
#16
Chloe J Bright, Mike M Hawkins, David L Winter, Daniela Alessi, Rodrigue S Allodji, Francesca Bagnasco, Edit Bárdi, Andrea Bautz, Julianne Byrne, Elizabeth A M Feijen, Miranda M Fidler, Stanislaw Garwicz, Desiree Grabow, Thorgerdur Gudmundsdottir, Joyeeta Guha, Nadia Haddy, Momcilo Jankovic, Peter Kaatsch, Melanie Kaiser, Claudia E Kuehni, Helena Linge, Hilde Øfstaas, Cecile M Ronckers, Roderick Skinner, Jop C Teepen, Monica Terenziani, Giao Vu-Bezin, Finn Wesenberg, Thomas Wiebe, Carlotta Sacerdote, Zsuzsanna Jakab, Riccardo Haupt, Päivi Lähteenmäki, Lorna Zadravec Zaletel, Rahel Kuonen, Jeanette F Winther, Florent de Vathaire, Leontien C Kremer, Lars Hjorth, Raoul C Reulen
Background: Childhood cancer survivors are at risk of subsequent primary soft-tissue sarcomas (STS), but the risks of specific STS histological subtypes are unknown. We quantified the risk of STS histological subtypes after specific types of childhood cancer. Methods: We pooled data from 13 European cohorts, yielding a cohort of 69 460 five-year survivors of childhood cancer. Standardized incidence ratios (SIRs) and absolute excess risks (AERs) were calculated. Results: Overall, 301 STS developed compared with 19 expected (SIR = 15...
November 20, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29165573/an-emerging-role-for-epigenetic-factors-in-relation-to-executive-function
#17
Omar Ibrahim, Heidi G Sutherland, Larisa M Haupt, Lyn R Griffiths
Executive function (EF) includes a range of decision-making and higher-order thinking processes. Although the genetic basis of EF has been studied and reviewed, epigenetic factors that influence EF are an emerging field of interest; here, we summarize the current research. Work relating to different word combinations of 'Executive Function' and 'Epigenetic' was identified through three academic search directories. Inclusion criteria were human populations, EF testing, epigenetic testing or genotyping related to epigenetic regulation...
November 20, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/29160303/the-pnpla3-i148m-variant-is-associated-with-transaminase-elevations-in-type-2-diabetes-patients-treated-with-basal-insulin-peglispro
#18
S Pillai, S Duvvuru, P Bhatnagar, W Foster, M Farmen, S Shankar, C Harris, E Bastyr, B Hoogwerf, A Haupt
Basal insulin peglispro (BIL) is a novel insulin with hepato-preferential action. In phase 3 trials, BIL showed significantly improved glycemic control but higher levels of transaminases (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), triglycerides (TGs) and liver fat content (LFC) compared with insulin glargine (GL). As variants in PNPLA3 (I148M) and TM6SF2 (E167K) are associated with nonalcoholic fatty liver disease, we assessed these variants in type 2 diabetes (T2D) patients randomized to receive BIL (n=1822) or GL (n=1270) in three phase 3 trials...
November 21, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29155942/detergent-based-decellularization-strategy-preserves-macro-and-microstructure-of-heart-valves
#19
Jessica Haupt, Georg Lutter, Stanislav N Gorb, Dan T Simionescu, Derk Frank, Jette Seiler, Alina Paur, Irma Haben
OBJECTIVES: Biological tissue has great potential to function as bioprostheses in patients for heart valve replacement. As these matrices are mainly xenogenic, the immunogenicity needs to be reduced by decellularization steps. Reseeding of bioscaffolds has tremendous potential to prevent calcification upon implantation, so intact microstructure of the material is mandatory. An optimal decellularization protocol of heart valves resulting in adequate preservation of the extracellular architecture has still not been developed...
October 9, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29121687/screening-for-type-1-diabetes-risk-in-newborns-the-freder1k-pilot-study-in-saxony
#20
Angela Hommel, Florian Haupt, Petrina Delivani, Christiane Winkler, Marina Stopsack, Pauline Wimberger, Katharina Nitzsche, Sophie Heinke, Andrea Naeke, Uta Ceglarek, Joachim Thiery, Renate Bergert, Daniel Stadthaus, Katrin Groeger, Georg Heubner, Ursula Schramm, Ullrich Dziambor, Agnes Zirkel, Wieland Kiess, Iris Mueller, Karin Lange, Reinhard Berner, Ezio Bonifacio, Anette-Gabriele Ziegler
An increased risk for type 1 diabetes can be identified using genetic and immune markers. The Freder1k study introduces genetic testing for type 1 diabetes risk within the context of the newborn screening in order to identify newborns with a high risk to develop type 1 diabetes for follow-up testing of early stage type 1 diabetes and for primary prevention trials. Consent for research-based genetic testing of type 1 diabetes risk is obtained with newborn screening. Increased risk is assessed using three single nucleotide polymorphisms for HLA DRB1*03 (DR3), HLA DRB1*04 (DR4), HLA DQB1*0302 (DQ8) alleles, and defined as 1...
November 9, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
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