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https://www.readbyqxmd.com/read/29322651/antifungal-dipeptides-incorporating-an-inhibitor-of-homoserine-dehydrogenase
#1
Andrzej S Skwarecki, Marta Schielmann, Dorota Martynow, Marcin Kawczyński, Aleksandra Wiśniewska, Maria J Milewska, Sławomir Milewski
The antifungal activity of 5-hydroxy-4-oxo-l-norvaline (HONV), exhibited under conditions mimicking human serum, may be improved upon incorporation of this amino acid into a dipeptide structure. Several HONV-containing dipeptides inhibited growth of human pathogenic yeasts of the Candida genus in the RPMI-1640 medium, with minimal inhibitory concentration values in the 32 to 64 μg mL-1 range. This activity was not affected by multidrug resistance that is caused by overexpression of genes encoding drug efflux proteins...
January 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29318898/path-planning-for-minimally-invasive-knee-surgery-using-a-hybrid-optimization-procedure
#2
Adam Ciszkiewicz, Grzegorz Milewski
The aim of this study was to develop a procedure for medical tool path planning in minimally-invasive knee surgery. The collision-free paths for the tool were obtained using the control locations method with a hybrid optimization strategy. The tool and knee elements were described with surface meshes. The knee model allowed for bones displacement and variable incision size and location. The proposed procedure was proven to be effective in path planning for minimally-invasive surgery. It can serve as a valuable aid in surgery planning and may also be used in systems for autonomous or semi-autonomous knee surgery...
January 10, 2018: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/29316179/a-novel-planning-solution-for-semi-autonomous-aspiration-of-baker-s-cysts
#3
Adam Ciszkiewicz, Jacek Lorkowski, Grzegorz Milewski
No abstract text is available yet for this article.
January 8, 2018: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29302181/medical-students-attitudes-toward-torture-revisited
#4
Krista Dubin, Andrew R Milewski, Joseph Shin, Thomas P Kalman
This paper reports the findings of a survey of medical students' attitudes toward torture and discusses variables that may correlate with those attitudes. In late 2016, 483 enrolled medical and MD-PhD students at the Weill Cornell Medical College received an anonymous, institutional review board-approved survey that included questions about torture and its effectiveness, demographic questions, inquiries about personal experiences of harassment or discrimination, and questions regarding engagement in human rights activities...
December 2017: Health and Human Rights
https://www.readbyqxmd.com/read/29286103/gene-expression-profiling-of-acute-myeloid-leukemia-samples-from-adult-patients-with-aml-m1-and-m2-through-boutique-microarrays-real-time-pcr-and-droplet-digital-pcr
#5
Luiza Handschuh, Maciej Kaźmierczak, Marek C Milewski, Michał Góralski, Magdalena Łuczak, Marzena Wojtaszewska, Barbara Uszczyńska-Ratajczak, Krzysztof Lewandowski, Mieczysław Komarnicki, Marek Figlerowicz
Acute myeloid leukemia (AML) is the most common and severe form of acute leukemia diagnosed in adults. Owing to its heterogeneity, AML is divided into classes associated with different treatment outcomes and specific gene expression profiles. Based on previous studies on AML, in this study, we designed and generated an AML-array containing 900 oligonucleotide probes complementary to human genes implicated in hematopoietic cell differentiation and maturation, proliferation, apoptosis and leukemic transformation...
December 28, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29282483/soluble-trem-1-serum-level-can-early-predict-mortality-of-patients-with-sepsis-severe-sepsis-and-septic-shock
#6
Monika Jedynak, Andrzej Siemiatkowski, Barbara Mroczko, Magdalena Groblewska, Robert Milewski, Maciej Szmitkowski
Early prognostic prediction of sepsis is essential in adjusting therapeutic protocols to prevent deterioration and reduce mortality. We compared the predictive value of the serum concentration of the soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) for 28-day mortality and for the development of severe sepsis or septic shock on the third day with the levels of interleukin (IL)-6, C-reactive protein (CRP) and procalcitonin (PCT). The study was conducted on 85 patients with sepsis. sTREM-1, CRP, PCT and IL-6 concentrations were measured upon study inclusion (day 0) and on days 1, 2, 3 and 5...
December 27, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29244688/arthrofibrosis-associated-with-the-surgical-treatment-of-chronic-lyme-arthritis-and-a-concomitant-medial-meniscal-tear-a-case-report
#7
Nathanael Tran, Matthew D Milewski
CASE: We describe a case of refractory Lyme arthritis in an adolescent patient with a concomitant medial meniscal tear. The patient underwent arthroscopic synovectomy and meniscal repair, and required additional surgery for subsequent decreased range of motion. We describe the presentation, the intraoperative findings, the course of recovery, and the literature regarding Lyme arthritis and meniscal tears. CONCLUSION: Refractory Lyme arthritis commonly is treated successfully with arthroscopic synovectomy...
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29234882/the-impact-of-hla-g-lilrb1-and-lilrb2-gene-polymorphisms-on-susceptibility-to-and-severity-of-endometriosis
#8
Aleksandra Bylińska, Karolina Wilczyńska, Jacek Malejczyk, Łukasz Milewski, Marta Wagner, Monika Jasek, Wanda Niepiekło-Miniewska, Andrzej Wiśniewski, Rafał Płoski, Ewa Barcz, Piotr Roszkowski, Paweł Kamiński, Andrzej Malinowski, Jacek R Wilczyński, Paweł Radwan, Michał Radwan, Piotr Kuśnierczyk, Izabela Nowak
Endometriosis is a disease in which endometriotic tissue occurs outside the uterus. Its pathogenesis is still unknown. The most widespread hypothesis claims that ectopic endometrium appears as a result of retrograde menstruation and its insufficient elimination by immunocytes. Some reports have shown expression of non-classical HLA-G molecules on ectopic endometrium. HLA-G is recognized by KIR2DL4, LILRB1 and LILRB2 receptors on natural killer (NK) and other cells. These receptors are polymorphic, which may affect their activity...
December 12, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29203070/a-sirolimus-eluting-bioabsorbable-polymer-coated-stent-mistent-versus-an-everolimus-eluting-durable-polymer-stent-xience-after-percutaneous-coronary-intervention-dessolve-iii-a-randomised-single-blind-multicentre-non-inferiority-phase-3-trial
#9
Robbert J de Winter, Yuki Katagiri, Taku Asano, Krzysztof P Milewski, Philipp Lurz, Pawel Buszman, Gillian A J Jessurun, Karel T Koch, Roland P T Troquay, Bas J B Hamer, Ton Oude Ophuis, Jochen Wöhrle, Rafał Wyderka, Guillaume Cayla, Sjoerd H Hofma, Sébastien Levesque, Aleksander Żurakowski, Dieter Fischer, Maciej Kośmider, Pascal Goube, E Karin Arkenbout, Michel Noutsias, Markus W Ferrari, Yoshinobu Onuma, William Wijns, Patrick W Serruys
BACKGROUND: MiStent is a drug-eluting stent with a fully absorbable polymer coating containing and embedding a microcrystalline form of sirolimus into the vessel wall. It was developed to overcome the limitation of current durable polymer drug-eluting stents eluting amorphous sirolimus. The clinical effect of MiStent sirolimus-eluting stent compared with a durable polymer drug-eluting stents has not been investigated in a large randomised trial in an all-comer population. METHODS: We did a randomised, single-blind, multicentre, phase 3 study (DESSOLVE III) at 20 hospitals in Germany, France, Netherlands, and Poland...
December 1, 2017: Lancet
https://www.readbyqxmd.com/read/29199101/versatility-of-putative-aromatic-aminotransferases-from-candida-albicans
#10
Kamila Rząd, Sławomir Milewski, Iwona Gabriel
Amino acids constitute the key sources of nitrogen for growth of Candida albicans. In order to survive inside the host in different and rapidly changing environments, this fungus must be able to adapt via its expression of genes for amino acid metabolism. We analysed the ARO8, ARO9, YER152C, and BNA3 genes with regards to their role in the nutritional flexibility of C. albicans. CaAro8p is undoubtedly the most versatile enzyme among the aminotransferases investigated. It is involved in the catabolism of histidine, lysine, and aromatic amino acids as well as in L-Lys, Phe and Tyr biosynthesis...
November 30, 2017: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/29168542/state-of-the-art-of-transcatheter-treatment-of-aortic-valve-stenosis-and-the-overview-of-the-inflow-project-aiming-at-developing-the-first-polish-tavi-system
#11
Mateusz Kachel, Krzysztof Milewski, Piotr Buszman, Magdalena Michalak, Wojciech Domaradzki, Witold Gerber, Joanna Śliwka, Jerzy Nożyński, Michał Sobota, Piotr Hirnle, Marzena Białek-Brodocz, Michał Zembala, Mariusz Pawlak, Emil Płowiecki, Janusz Kasperczyk, Arkadiusz Mężyk, Andrzej Bochenek, Paweł Buszman
No abstract text is available yet for this article.
November 23, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29163437/transport-deficiency-is-the-molecular-basis-of-candida-albicans-resistance-to-antifungal-oligopeptides
#12
Marta Schielmann, Piotr Szweda, Katarzyna Gucwa, Marcin Kawczyński, Maria J Milewska, Dorota Martynow, Joachim Morschhäuser, Sławomir Milewski
Oligopeptides incorporating N(3)-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP), an inhibitor of glucosamine-6-phosphate synthase, exhibited growth inhibitory activity against Candida albicans, with minimal inhibitory concentration values in the 0.05-50 μg mL(-1) range. Uptake by the peptide permeases was found to be the main factor limiting an anticandidal activity of these compounds. Di- and tripeptide containing FMDP (F2 and F3) were transported by Ptr2p/Ptr22p peptide transporters (PTR) and FMDP-containing hexa-, hepta-, and undecapeptide (F6, F7, and F11) were taken up by the oligopeptide transporters (OPT) oligopeptide permeases, preferably by Opt2p/Opt3p...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29153427/does-a-mobile-ecls-program-reduce-mortality-for-patients-transported-for-ecls-therapy-for-severe-acute-respiratory-failure
#13
Jacob T Gutsche, Todd A Miano, William Vernick, Jesse Raiten, Christian Bermudez, Prashant Vallabjoysula, Karianna Milewski, Wilson Szeto, Meghan Lane Fall, Matthew L Williams, Prakash Patel, Mark E Mikkelsen, Cornel Chiu, Harish Ramakrishna, Jeremy Canon, John G Augoustides
OBJECTIVE: To understand if mobile extracorporeal membrane oxygenation reduces patient mortality during and after transport of patients requiring extracorporeal membrane oxygenation for acute respiratory distress syndrome. DESIGN: Retrospective chart review. SETTING: University affiliated tertiary care hospitals. PARTICIPANTS: Seventy-seven patients. INTERVENTIONS: Introduction of a mobile extracorporeal membrane oxygenation (ECMO) program designed to facilitate the implementation of ECMO at outside hospitals in patients too unstable for transport for ECMO...
September 2, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29099056/ammonia-reduces-intracellular-asymmetric-dimethylarginine-in-cultured-astrocytes-stimulating-its-y%C3%A2-%C2%BAlat2-carrier-mediated-loss
#14
Krzysztof Milewski, Małgorzata Bogacińska-Karaś, Inez Fręśko, Wojciech Hilgier, Radosław Jaźwiec, Jan Albrecht, Magdalena Zielińska
Previously we had shown that ammonia stimulates nitric oxide (NO) synthesis in astrocytes by increasing the uptake of the precursor amino acid, arginine via the heteromeric arginine/glutamine transporter y⁺LAT2. Ammonia also increases the concentration in the brain of the endogenous inhibitor of nitric oxide synthases (NOS), asymmetric dimethylarginine (ADMA), but distribution of ADMA surplus between the intraastrocytic and extracellular compartments of the brain has not been studied. Here we tested the hypothesis that ammonia modulates the distribution of ADMA and its analog symmetric dimethylarginine (SDMA) between the two compartments of the brain by competition with arginine for the y⁺LAT2 transporter...
November 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29073303/significant-differences-in-parameters-of-glucose-metabolism-in-children-of-hypertensive-and-normotensive-parents
#15
Anna Gryko, Barbara Głowińska-Olszewska, Katarzyna Płudowska, W Henry Smithson, Anna Owłasiuk, Beata Żelazowska-Rutkowska, Katarzyna Wojtkielewicz, Robert Milewski, Sławomir Chlabicz
INTRODUCTION: In the recent years, alterations in the carbohydrate metabolism, including insulin resistance, are considered as risk factors in the development of hypertension and its complications in young age. Hypertension is associated with significant cardiovascular morbidity and mortality. The onset of pathology responsible for the development of hypertension, as well as levels of biomarkers specific for early stages of atherosclerosis are poorly understood. AIM: To compare a group of children whose parents have a history of hypertension (study group) with a group of children with normotensive parents (reference group), with consideration of typical risk factors for atherosclerosis, parameters of lipid and carbohydrate metabolism, anthropometric data and new biomarkers of early cardiovascular disease (hsCRP, adiponectin, sICAM-1)...
2017: Pediatric Endocrinology, Diabetes, and Metabolism
https://www.readbyqxmd.com/read/29030347/extracellular-matrix-proteomics-reveals-interplay-of-aggrecan-and-aggrecanases-in-vascular-remodeling-of-stented-coronary-arteries
#16
Gonca Suna, Wojciech Wojakowski, Marc Lynch, Javier Barallobre-Barreiro, Xiaoke Yin, Ursula Mayr, Ferheen Baig, Ruifang Lu, Marika Fava, Robert Hayward, Chris Molenaar, Stephen J White, Tomasz Roleder, Krzysztof Milewski, Pawel Gasior, Piotr P Buszman, Pawel E Buszman, Marjan Jahangiri, Cathy Shanahan, Jonathan M Hill, Manuel Mayr
Background -Extracellular matrix (ECM) remodeling contributes to in-stent restenosis and thrombosis. Despite its important clinical implications little is known about ECM changes post-stent implantation. Methods -Bare-metal (BMS) and drug-eluting stents (DES) were implanted in pig coronary arteries with an overstretch under optical coherence tomography guidance. Stented segments were harvested 1, 3, 7, 14 and 28 days post-stenting for proteomics analysis of the media and neointima. Results -A total of 151 ECM and ECM-associated proteins were identified by mass spectrometry...
October 13, 2017: Circulation
https://www.readbyqxmd.com/read/28993454/dynamics-of-cytoplasm-and-cleavage-divisions-correlates-with-preimplantation-embryo-development
#17
Robert Milewski, Marcin Szpila, Anna Maria Ajduk
In vitro fertilization has become increasingly popular as an infertility treatment. In order to improve efficiency of this procedure, there is a strong need for a refinement of existing embryo assessment methods and development of novel, robust and non-invasive selection protocols. Studies conducted on animal models can be extremely helpful here, as they allow for more extensive research on the potential biomarkers of embryo quality. In the present paper we subjected mouse embryos to non-invasive time-lapse imaging and combine the Particle Image Velocimetry analysis of cytoplasmic dynamics in freshly fertilized oocytes with the morphokinetic analysis of recordings covering 5 days of preimplantation development...
October 9, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28980380/safety-and-feasibility-of-same-day-early-discharge-after-endovascular-revascularization-of-lower-extremities-in-elderly-senior-er-registry
#18
Adam Janas, Krzysztof Milewski, Piotr P Buszman, Ksenia Janas, Aleksandra Blachut, Maciej Pruski, Szymon Wiernek, Aleksander Zurakowski, Pawel E Buszman, Stefan R Kiesz
OBJECTIVE: The aim of the study was to assess safety and feasibility of one-day early discharge (ODD) after endovascular revascularization (ER) of lower extremities in elderly. BACKGROUND: Safety and feasibility of ODD after ER have never been investigated in the elderly, despite the PAD rate has been rising in well-developed countries as their populations are getting older. METHODS: The consecutive data of 477 patients after ER who were intended to ODD were reviewed...
October 5, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28944351/the-effect-of-nonsurgical-periodontal-therapy-on-the-level-of-human-neutrophil-peptides-1-3-in-patients-with-aggressive-periodontitis
#19
Ewa Dolińska, Anna Skurska, Violetta Dymicka-Piekarska, Robert Milewski, Jan Pietruski, Małgorzata Pietruska, Anton Sculean
PURPOSE: To assess the presence of HNP1-3 in the gingival crevicular fluid (GCF) of patients suffering from aggressive periodontitis before and after nonsurgical periodontal therapy. MATERIALS AND METHODS: Twenty patients, each with generalised aggressive periodontitis (GAP) were included in the study. After periodontal examination, one site with a probing depth (PD) ≥ 4 mm was selected. Patients received nonsurgical treatment (scaling and root planing [SRP]) with additional administration of systemic antibiotic therapy (amoxicillin 375 mg three times daily + metronidazole 250 mg three times daily for 7 days)...
September 21, 2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28940383/immunoproteasome-in-the-blood-plasma-of-children-with-acute-appendicitis-and-its-correlation-with-proteasome-and-uchl1-measured-by-spr-imaging-biosensors
#20
E Matuszczak, A Sankiewicz, W Debek, E Gorodkiewicz, R Milewski, A Hermanowicz
The aim of this study was to determinate the immunoproteasome concentration in the blood plasma of children with appendicitis, and its correlation with circulating proteasome and ubiquitin carboxyl-terminal hydrolase L1 (UCHL1). Twenty-seven children with acute appendicitis, managed at the Paediatric Surgery Department, were included randomly into the study (age 2 years 9 months up to 14 years, mean age 9·5 ± 1 years). There were 10 girls and 17 boys; 18 healthy, age-matched subjects, admitted for planned surgeries served as controls...
January 2018: Clinical and Experimental Immunology
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