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https://www.readbyqxmd.com/read/27885576/asymmetric-dimethylarginine-and-hepatic-encephalopathy-cause-effect-or-association
#1
Anna Czarnecka, Krzysztof Milewski, Magdalena Zielińska
The methylated derivative of L-arginine, asymmetric dimethylarginine (ADMA) is synthesized in different mammalian tissues including the brain. ADMA acts as an endogenous, nonselective, competitive inhibitor of all three isoforms of nitric oxide synthase (NOS) and may limit L-arginine supply from the plasma to the enzyme via reducing its transport by cationic amino acid transporters. Hepatic encephalopathy (HE) is a relatively frequently diagnosed complex neuropsychiatric syndrome associated with acute or chronic liver failure, characterized by symptoms linked with impaired brain function leading to neurological disabilities...
November 25, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27812233/new-hybrid-pectin-based-biosorbents
#2
Agata Jakóbik-Kolon, Andrzej K Milewski, Krzysztof Karoń, Joanna Bok-Badura
In this work hybrid pectin-based biosorbents with secondary polysaccharide additives (gellan, carob and xanthan gum, ratio to pectin 1:1, 1:1 and 1:3, respectively) were obtained at two temperatures. The presence of these additives in prepared beads was confirmed by Raman spectra. The SEM micrographs show better homogeneity of blends and grater differences between structures of beads with various additives obtained at higher temperature. The sorption capacity of our hybrid biosorbents as well as sole pectin sorbent is rather the same, and equals 0...
November 1, 2016: Separation Science and Technology
https://www.readbyqxmd.com/read/27798791/anterolateral-ligament-of-the-knee-shows-variable-anatomy-in-pediatric-specimens
#3
Kevin G Shea, Matthew D Milewski, Peter C Cannamela, Theodore J Ganley, Peter D Fabricant, Elizabeth B Terhune, Alexandra C Styhl, Allen F Anderson, John D Polousky
BACKGROUND: Anterior cruciate ligament (ACL) reconstruction failure rates are highest in youth athletes. The role of the anterolateral ligament in rotational knee stability is of increasing interest, and several centers are exploring combined ACL and anterolateral ligament reconstruction for these young patients. Literature on the anterolateral ligament of the knee is sparse in regard to the pediatric population. A single study on specimens younger than age 5 years demonstrated the presence of the anterolateral ligament in only one of eight specimens; therefore, much about the prevalence and anatomy of the anterolateral ligament in pediatric specimens remains unknown...
October 31, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27793802/a-sequence-upstream-of-canonical-pdz-binding-motif-within-cftr-c-terminus-enhances-nherf1-interaction
#4
Neeraj Sharma, Jessica LaRusch, Patrick Sosnay, Laura B Gottschalk, Andrea Lopez, Matthew J Pellicore, Taylor Evans, Emily Davis, Melis Atalar, Chan-Hyun Na, Gedge D Rosson, Deborah Belchis, Michal Milewski, Akhilesh Pandey, Garry R Cutting
The development of CFTR targeted therapy for cystic fibrosis has generated interest in maximizing membrane residence of mutant forms of CFTR by manipulating interactions with scaffold proteins such as NHERF1. In this study, we explored whether C-terminal sequences in CFTR beyond the PDZ-binding motif influence its interaction with NHERF1. NHERF1 displayed minimal self-association in blot overlays (NHERF1, Kd = 1382 ± 61.1 nM) at concentrations well above physiologic levels, estimated at 240 nM from RNA-Seq and 260 nM by LC-MS/MS in sweat gland, a key site of CFTR function in vivo...
October 28, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27776368/erratum-research-in-osteochondritis-dissecans-of-the-knee-2016-update
#5
Jeffrey J Nepple, Matthew D Milewski, Kevin G Shea
No abstract text is available yet for this article.
October 24, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27738667/how-short-rnas-impact-the-human-ribonuclease-dicer-activity-putative-regulatory-feedback-loops-and-other-rna-mediated-mechanisms-controlling-microrna-processing
#6
Natalia Koralewska, Weronika Hoffmann, Maria Pokornowska, Marek Milewski, Andrea Lipinska, Krystyna Bienkowska-Szewczyk, Marek Figlerowicz, Anna Kurzynska-Kokorniak
Ribonuclease Dicer plays a pivotal role in RNA interference pathways by processing long double-stranded RNAs and single-stranded hairpin RNA precursors into small interfering RNAs (siRNAs) and microRNAs (miRNAs), respectively. While details of Dicer regulation by a variety of proteins are being elucidated, less is known about non-protein factors, e.g. RNA molecules, that may influence this enzyme's activity. Therefore, we decided to investigate the question of whether the RNA molecules can function not only as Dicer substrates but also as its regulators...
October 13, 2016: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/27731934/the-perioperative-lung-transplant-virome-torque-teno-viruses-are-elevated-in-donor-lungs-and-show-divergent-dynamics-in-primary-graft-dysfunction
#7
A A Abbas, J M Diamond, C Chehoud, B Chang, J J Kotzin, J C Young, I Imai, A R Haas, E Cantu, D J Lederer, K Meyer, R K Milewski, K M Olthoff, A Shaked, J D Christie, F D Bushman, R G Collman
Primary graft dysfunction (PGD) is a principal cause of early morbidity and mortality after lung transplantation, but its pathogenic mechanisms are not fully clarified. Thus far, studies using standard clinical assays have not linked microbial factors to PGD. We previously used comprehensive metagenomic methods to characterize viruses in lung allografts >1 month post-transplant and found that levels of Anellovirus, mainly Torque teno viruses (TTV), were significantly higher than in non-transplant healthy controls...
October 12, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27713555/lipid-metabolism-is-associated-with-developmental-epigenetic-programming
#8
Elizabeth H Marchlewicz, Dana C Dolinoy, Lu Tang, Samantha Milewski, Tamara R Jones, Jaclyn M Goodrich, Tanu Soni, Steven E Domino, Peter X K Song, Charles F Burant, Vasantha Padmanabhan
Maternal diet and metabolism impact fetal development. Epigenetic reprogramming facilitates fetal adaptation to these in utero cues. To determine if maternal metabolite levels impact infant DNA methylation globally and at growth and development genes, we followed a clinical birth cohort of 40 mother-infant dyads. Targeted metabolomics and quantitative DNA methylation were analyzed in 1st trimester maternal plasma (M1) and delivery maternal plasma (M2) as well as infant umbilical cord blood plasma (CB). We found very long chain fatty acids, medium chain acylcarnitines, and histidine were: (1) stable in maternal plasma from pregnancy to delivery, (2) significantly correlated between M1, M2, and CB, and (3) in the top 10% of maternal metabolites correlating with infant DNA methylation, suggesting maternal metabolites associated with infant DNA methylation are tightly controlled...
October 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27666785/central-repair-with-antegrade-tevar-for-malperfusion-syndromes-in-acute-debakey-i-aortic-dissection
#9
Prashanth Vallabhajosyula, Jean Paul Gottret, Rohan Menon, Ibrahim Sultan, Zara Abbas, Mary Siki, Matthew Kramer, Aaron Pulsipher, Suveeksha Naidu, Alberto Pochettino, Kariana Milewski, Wilson Y Szeto, Joseph E Bavaria
BACKGROUND: In acute DeBakey I aortic dissection presenting with malperfusion syndromes, we assessed whether standard open repair with concomitant antegrade stent grafting (thoracic endovascular aneurysm repair; TEVAR) of the descending thoracic aorta (DTA) improves outcomes compared with standard repair alone. METHODS: From 2005 to 2012, 277 patients with acute DeBakey I dissection underwent emergent operation. Of these, 104 patients (37%) presenting with end-organ malperfusion were divided into those undergoing standard distal repair entailing transverse hemiarch replacement (Standard group, n = 65) versus standard repair with concomitant DTA TEVAR during circulatory arrest (TEVAR group, n = 39)...
September 22, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27628188/platelet-indices-in-late-preterm-newborns
#10
Wasiluk Alicja, Polewko Agnieszka, Laudanski Piotr, Redzko Slawomir, Kicel-Wesolowska Barbara, Dabrowska Milena, Milewski Robert
BACKGROUND: The current study objective was to compare blood platelet indices in late preterm newborns (LPN) and full term newborns (FTN). MATERIALS AND METHODS: We recruited 58 LPN and 71 FTN. Platelet indices were estimated in blood samples collected from the umbilical artery. RESULTS: LPN demonstrated a decreased count of blood platelets (249 × 10³/μL) as compared to FTN (295 × 10³/μL), p < 0.001. Platelet hematocrit (PCT) also showed substantial differences in both groups (LPN = 0...
October 6, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27625684/evaluation-of-safety-and-efficacy-of-nexgen-an-ultrathin-strut-and-hybrid-cell-design-cobalt-chromium-bare-metal-stent-implanted-in-a-real-life-patient-population-the-polish-nexgen-registry
#11
Krzysztof Milewski, Paweł Gąsior, Stefan Samborski, Piotr P Buszman, Aleksandra Błachut, Adam Wojtaszczyk, Adam Młodziankowski, Artur Mendyk, Marek Król, Wojciech Wojakowski, Paweł E Buszman
INTRODUCTION: Despite the dominance of drug-eluting stents in modern interventional cardiology, there is still a niche for bare metal stents. AIM: The aim of the Polish NexGen registry was to evaluate the safety and efficacy of a new generation cobalt-chromium NexGen stent in a real life patient population. MATERIAL AND METHODS: A prospective multi-center registry was conducted in five clinical sites of American Heart of Poland. Three hundred and eighty-three patients who underwent percutaneous coronary intervention (PCI) with NexGen stent implantation were included...
2016: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/27616010/serum-irisin-and-its-regulation-by-hyperinsulinemia-in-women-with-polycystic-ovary-syndrome
#12
Agnieszka Adamska, Monika Karczewska-Kupczewska, Agnieszka Lebkowska, Robert Milewski, Maria Górska, Elzbieta Otziomek, Agnieszka Nikolajuk, Slawomir Wolczynski, Irina Kowalska
Irisin is an adipokine/myokine which could be connected with insulin sensitivity. Polycystic ovary syndrome (PCOS) is characterized by oligo- or anovulation, polycystic ovary, hyperandrogenism and insulin resistance. The aim of the present study was to determine the relationship between serum irisin concentration and insulin sensitivity (Mffm) as well as the effect of insulin infusion on circulating irisin levels in PCOS women as compared with healthy controls. Seventy seven women were enrolled in the study - 57 with PCOS and 20 healthy controls matched for BMI and age...
September 8, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27604531/physeal-fractures-about-the-knee
#13
REVIEW
Rhianna M Little, Matthew D Milewski
While some fractures may be managed similarly in adults and children, physeal fractures are uniquely limited to the pediatric population and require special consideration. Although physeal fractures about the knee are relatively rare, they are occurring more frequently due to increasing youth participation in sports and high-energy recreational activities. The evaluation and management of distal femoral and proximal tibial physeal fractures are similar to one another, but fractures of the tibial spine and tibial tubercle are approached somewhat differently...
December 2016: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/27604291/intracerebral-administration-of-s-adenosylhomocysteine-or-s-adenosylmethionine-attenuates-the-increases-in-the-cortical-extracellular-levels-of-dimethylarginines-without-affecting-cgmp-level-in-rats-with-acute-liver-failure
#14
Anna Czarnecka, Krzysztof Milewski, Radosław Jaźwiec, Magdalena Zielińska
Alterations in brain nitric oxide (NO)/cGMP synthesis contribute to the pathogenesis of hepatic encephalopathy (HE). An increased asymmetrically dimethylated derivative of L-arginine (ADMA), an endogenous inhibitor of NO synthases, was observed in plasma of HE patients and animal models. It is not clear whether changes in brain ADMA reflect its increased local synthesis therefore affecting NO/cGMP pathway, or are a consequence of its increased peripheral blood content. We measured extracellular concentration of ADMA and symmetrically dimethylated isoform (SDMA) in the prefrontal cortex of control and thioacetamide (TAA)-induced HE rats...
September 8, 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/27598204/towards-a-better-molecular-diagnosis-of-fmr1-related-disorders-a-multiyear-experience-from-a-reference-lab
#15
Sylwia Olimpia Rzońca, Monika Gos, Daniel Szopa, Danuta Sielska-Rotblum, Aleksandra Landowska, Agnieszka Szpecht-Potocka, Michał Milewski, Jolanta Czekajska, Anna Abramowicz, Ewa Obersztyn, Dorota Maciejko, Tadeusz Mazurczak, Jerzy Bal
The article summarizes over 20 years of experience of a reference lab in fragile X mental retardation 1 gene (FMR1) molecular analysis in the molecular diagnosis of fragile X spectrum disorders. This includes fragile X syndrome (FXS), fragile X-associated primary ovarian insufficiency (FXPOI) and fragile X-associated tremor/ataxia syndrome (FXTAS), which are three different clinical conditions with the same molecular background. They are all associated with an expansion of CGG repeats in the 5'UTR of FMR1 gene...
2016: Genes
https://www.readbyqxmd.com/read/27532280/research-in-osteochondritis-dissecans-of-the-knee-2016-update
#16
Jeffrey J Nepple, Matthew D Milewski, Kevin G Shea
Osteochondritis dissecans (OCD) of the knee remains a relatively common and poorly understood pediatric and adolescent knee condition. Both conservative and surgical treatments have major impact on the lives of young active, athletic patients with knee OCD. OCD has been recently redefined as a "focal, idiopathic alteration of subchondral bone with risk for instability and disruption of adjacent articular cartilage that may result in premature osteoarthritis." The 2011 American Academy of Orthopedic Surgeons Clinical Practice Guidelines found limited evidence for all aspects of the treatment of knee OCD...
October 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27518195/effects-of-different-omeprazole-dosing-on-gastric-ph-in-nonvariceal-upper-gastrointestinal-bleeding-a-randomized-prospective-study
#17
Adam Chwiesko, Radoslaw Charkiewicz, Jacek Niklinski, Wojciech Luczaj, Elzbieta Skrzydlewska, Robert Milewski, Andrzej Baniukiewicz, Eugeniusz Wroblewski, Mariusz Rosolowski, Andrzej Dabrowski
AIM: We aimed to identify the best method of omeprazole (OME) application with respect to intragastric pH, cytochrome CYP2C19 genotype and phenotype. METHODS: Fifty patients with NVUGIB were prospectively enrolled, after achievement of endoscopic hemostasis, were randomized to 40-mg IV OME bolus injection bid or 80-mg IV bolus injection + 8-mg/h continuous IV infusion for 72 hours. The intragastric pH was recorded for 72 hours. The CYP2C19 variant alleles (*2, *3, *17) were analysed, the serum concentrations of OME and 5-hydroxy-OME were determined...
August 12, 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27474384/the-relationship-of-the-femoral-physis-and-the-medial-patellofemoral-ligament-in-children-a-cadaveric-study
#18
Kevin G Shea, Alexandra C Styhl, John C Jacobs, Theodore J Ganley, Matthew D Milewski, Peter C Cannamela, Allen F Anderson, John D Polousky
BACKGROUND: Young athletes sustain patellar dislocations in a variety of sports. The medial patellofemoral ligament (MPFL) is a critical structure that functions as an anatomic checkrein to help prevent lateral patellar dislocation. Reconstruction of this ligament is challenging in patients with open physes because of concerns about iatrogenic damage to the femoral physis. PURPOSE: To evaluate the relationship of the distal femoral physis and the MPFL. STUDY DESIGN: Descriptive laboratory study...
November 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27425595/foxf1-and-foxf2-transcription-factors-synergistically-promote-rhabdomyosarcoma-carcinogenesis-by-repressing-transcription-of-p21-cip1-cdk-inhibitor
#19
D Milewski, A Pradhan, X Wang, Y Cai, T Le, B Turpin, V V Kalinichenko, T V Kalin
The role of Forkhead Box F1 (FoxF1) transcription factor in carcinogenesis is not well characterized. Depending on tissue and histological type of cancer, FoxF1 has been shown to be either an oncogene or a tumor suppressor. Alveolar rhabdomyosarcoma (RMS) is the most aggressive pediatric soft-tissue sarcoma. Although FoxF1 is highly expressed in alveolar RMS, the functional role of FoxF1 in RMS is unknown. The present study demonstrates that expression of FoxF1 and its closely related transcription factor FoxF2 are essential for RMS tumor growth...
July 18, 2016: Oncogene
https://www.readbyqxmd.com/read/27400835/a-standardized-production-pipeline-for-high-profile-targets-from-mycobacterium-tuberculosis
#20
Morlin C Milewski, Tobias Broger, Joanna Kirkpatrick, Angela Filomena, Dana Komadina, Nicole Schneiderhan-Marra, Matthias Wilmanns, Annabel H A Parret
PURPOSE: Tuberculosis is still a major threat to global health. New tools and strategies to produce disease-related proteins are quintessential for the development of novel vaccines and diagnostic markers. EXPERIMENTAL DESIGN: To obtain recombinant proteins from Mycobacterium tuberculosis (Mtb) for use in clinical applications, a standardized procedure was developed that includes subcloning, protein expression in Mycobacterium smegmatis and protein purification using chromatography...
July 12, 2016: Proteomics. Clinical Applications
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