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https://www.readbyqxmd.com/read/28099101/myeloperoxidase-nuclear-imaging-for-epileptogenesis
#1
Yinian Zhang, Daniel P Seeburg, Benjamin Pulli, Gregory R Wojtkiewicz, Lionel Bure, Wendy Atkinson, Stefan Schob, Yoshiko Iwamoto, Muhammad Ali, Wei Zhang, Elisenda Rodriguez, Andrew Milewski, Edmund J Keliher, Cuihua Wang, Yawen Pan, Filip K Swirski, John W Chen
No abstract text is available yet for this article.
February 2017: Radiology
https://www.readbyqxmd.com/read/28090010/long-term-outcomes-after-percutaneous-lower-extremity-arterial-interventions-with-atherectomy-vs-balloon-angioplasty%C3%A3-propensity-score-matched-registry
#2
Adam Janas, Piotr P Buszman, Krzysztof P Milewski, Szymon Wiernek, Ksenia Janas, Maciej Pruski, Wojciech Wojakowski, Aleksandra Błachut, Wojciech Picheta, Pawel Buszman, Stefan Kiesz
BACKGROUND: The impact of endovascular revascularization of the lower extremity arteries with atherectomy (AT) compared with percutaneous transluminal angioplasty (PTA) is still unclear. Therefore, the aim of the study was to compare long-term outcomes after percutaneous PTA and AT in patients requiring endovascular revascularization.Methods and Results:This was a single-center, retrospective registry of obstructive and symptomatic PAD patients who underwent endovascular revascularization...
January 14, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28067591/association-between-vitamin-d-receptor-polymorphism-and-serum-vitamin-d-levels-in-children-with-low-energy-fractures
#3
Michal Karpiński, Anna Galicka, Robert Milewski, Janusz Popko, Vladimir Badmaev, Sidney J Stohs
OBJECTIVE: Fractures of bones, especially forearm fractures, are very common in children and their number is increasing. This study was designed to determine the impact of vitamin D serum levels and vitamin D receptor (VDR) polymorphisms on the occurrence of low-energy fractures in children. METHODS: The study group consisted of 100 children with clinically relevant bone fractures and a control group consisted of 127 children without fractures. Total vitamin D [25(OH)D3 plus 25(OH)D2] serum concentrations were evaluated in every patient...
January 9, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28043359/aberrant-effects-of-altrenogest-and-exposure-to-exogenous-gonadotropins-on-follicular-cysts-appearance-in-gilts
#4
A J Ziecik, J Klos, E Przygrodzka, R Milewski, B Jana
Research was conducted to determine the effect of altrenogest and exposure to exogenous gonadotropins on ovarian function in prepubertal and mature gilts. Crossbred, presumably sexually mature gilts (n = 51), were fed with altrenogest for 18 consecutive days and the day after the last feeding with altrenogest, gilts were treated with eCG and 72 hours later challenged with hCG. Animals were slaughtered on Days 10 to 13 of their gonadotropins synchronized estrous cycle. Ovaries were examined for the number of CL, number of follicular cysts, and presence of corpora albicantia...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/28019051/remote-supervision-to-decrease-hospitalization-rate-unified-and-integrated-platform-for-data-collected-from-devices-manufactured-by-different-companies-design-and-rationale-of-the-result-study
#5
Mateusz Tajstra, Adam Sokal, Arkadiusz Gwóźdź, Marcin Wilczek, Adam Gacek, Konrad Wojciechowski, Elżbieta Gadula-Gacek, Elżbieta Adamowicz-Czoch, Katarzyna Chłosta-Niepiekło, Krzysztof Milewski, Piotr Rozentryt, Zbigniew Kalarus, Mariusz Gąsior, Lech Poloński
The number of patients with heart failure implantable cardiac electronic devices (CIEDs) is growing. Hospitalization rate in this group is very high and generates enormous costs. To avoid the need for hospital treatment, optimized monitoring and follow-up is crucial. Remote monitoring (RM) has been widely put into practice in the management of CIEDs but it may be difficult due to the presence of differences in systems provided by device manufacturers and loss of gathered data in case of device reimplantation...
December 25, 2016: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/27976797/comparable-vascular-response-of-a-new-generation-sirolimus-eluting-stents-when-compared-to-fluoropolymer-everolimus-eluting-stents-in-the-porcine-coronary-restenosis-model
#6
Piotr P Buszman, Magdalena J Michalak, Maciej Pruski, Carlos Fernandez, Michał Jelonek, Adam Janas, Claudine Savard, Beata Gwiazdowska-Nowotka, Aleksander Żurakowski, Wojciech Wojakowski, Paweł E Buszman, Krzysztof Milewski
BACKGROUND: Novel sirolimus eluting stents (SES) have shown non-inferior clinical outcomes when compared to everolimus eluting stents (EES), however only limited preclinical data have been published. Therefore, we evaluate vascular response of a new generation biodegradable polymer SES (BP-SES: Alex Plus, Balton) and fluoropolymer EES (EES: Xience Pro, Abbott) in the porcine coronary restenosis model. METHODS: A total of 40 stents were implanted with 120% overstretch in coronaries of 17 domestic swine: 16 BP-SES, 16 EES and 8 bare metal controls (BMS)...
2016: Cardiology Journal
https://www.readbyqxmd.com/read/27970228/tct-837-comparable-vascular-response-of-a-new-generation-sirolimus-eluting-stents-when-compared-to-fluoropolymer-everolimus-eluting-stents-in-the-porcine-coronary-restenosis-model
#7
Piotr Buszman, Magdalena Michalak, Maciej Pruski, Michał Jelonek, Adam Janas, Aleksander Żurakowski, Beata Gwiazdowska-Nowotka, Wojtek Wojakowski, Paweł Buszman, Krzysztof Milewski
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970192/tct-803-long-term-outcomes-in-diabetic-patients-treated-with-atherectomy-for-peripheral-artery-disease
#8
Adam Janas, Piotr Buszman, Krzysztof Milewski, Marek Król, Wojciech Fil, Wojtek Wojakowski, Przemek Nowakowski, Aleksandra Blachut, Maciej Pruski, Pawel Buszman, R Stefan Kiesz
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27958618/morphokinetic-parameters-as-a-source-of-information-concerning-embryo-developmental-and-implantation-potential
#9
Robert Milewski, Jan Czerniecki, Agnieszka Kuczyńska, Bożena Stankiewicz, Waldemar Kuczyński
OBJECTIVES: The aim of the study was to present the results of time-lapse observation and to verify whether morphokinetic parameters are associated with embryo developmental and implantation potential. MATERIAL AND METHODS: The analysed data concern the development of 1,060 embryos, 898 of which (84.72%) achieved the blastocyst stage and 307 were transferred into the uterine cavity. As a result, 126 (41.04%) biochemical pregnancies and 109 (35.50%) clinical pregnancies were observed...
2016: Ginekologia Polska
https://www.readbyqxmd.com/read/27885576/asymmetric-dimethylarginine-and-hepatic-encephalopathy-cause-effect-or-association
#10
Anna Czarnecka, Krzysztof Milewski, Magdalena Zielińska
The methylated derivative of L-arginine, asymmetric dimethylarginine (ADMA) is synthesized in different mammalian tissues including the brain. ADMA acts as an endogenous, nonselective, competitive inhibitor of all three isoforms of nitric oxide synthase (NOS) and may limit L-arginine supply from the plasma to the enzyme via reducing its transport by cationic amino acid transporters. Hepatic encephalopathy (HE) is a relatively frequently diagnosed complex neuropsychiatric syndrome associated with acute or chronic liver failure, characterized by symptoms linked with impaired brain function leading to neurological disabilities...
November 25, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27812233/new-hybrid-pectin-based-biosorbents
#11
Agata Jakóbik-Kolon, Andrzej K Milewski, Krzysztof Karoń, Joanna Bok-Badura
In this work hybrid pectin-based biosorbents with secondary polysaccharide additives (gellan, carob and xanthan gum, ratio to pectin 1:1, 1:1 and 1:3, respectively) were obtained at two temperatures. The presence of these additives in prepared beads was confirmed by Raman spectra. The SEM micrographs show better homogeneity of blends and grater differences between structures of beads with various additives obtained at higher temperature. The sorption capacity of our hybrid biosorbents as well as sole pectin sorbent is rather the same, and equals 0...
November 1, 2016: Separation Science and Technology
https://www.readbyqxmd.com/read/27798791/anterolateral-ligament-of-the-knee-shows-variable-anatomy-in-pediatric-specimens
#12
Kevin G Shea, Matthew D Milewski, Peter C Cannamela, Theodore J Ganley, Peter D Fabricant, Elizabeth B Terhune, Alexandra C Styhl, Allen F Anderson, John D Polousky
BACKGROUND: Anterior cruciate ligament (ACL) reconstruction failure rates are highest in youth athletes. The role of the anterolateral ligament in rotational knee stability is of increasing interest, and several centers are exploring combined ACL and anterolateral ligament reconstruction for these young patients. Literature on the anterolateral ligament of the knee is sparse in regard to the pediatric population. A single study on specimens younger than age 5 years demonstrated the presence of the anterolateral ligament in only one of eight specimens; therefore, much about the prevalence and anatomy of the anterolateral ligament in pediatric specimens remains unknown...
October 31, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27793802/a-sequence-upstream-of-canonical-pdz-binding-motif-within-cftr-cooh-terminus-enhances-nherf1-interaction
#13
Neeraj Sharma, Jessica LaRusch, Patrick R Sosnay, Laura B Gottschalk, Andrea P Lopez, Matthew J Pellicore, Taylor Evans, Emily Davis, Melis Atalar, Chan-Hyun Na, Gedge D Rosson, Deborah Belchis, Michal Milewski, Akhilesh Pandey, Garry R Cutting
The development of cystic fibrosis transmembrane conductance regulator (CFTR) targeted therapy for cystic fibrosis has generated interest in maximizing membrane residence of mutant forms of CFTR by manipulating interactions with scaffold proteins, such as sodium/hydrogen exchange regulatory factor-1 (NHERF1). In this study, we explored whether COOH-terminal sequences in CFTR beyond the PDZ-binding motif influence its interaction with NHERF1. NHERF1 displayed minimal self-association in blot overlays (NHERF1, Kd = 1,382 ± 61...
December 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27776368/erratum-research-in-osteochondritis-dissecans-of-the-knee-2016-update
#14
Jeffrey J Nepple, Matthew D Milewski, Kevin G Shea
No abstract text is available yet for this article.
November 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27738667/how-short-rnas-impact-the-human-ribonuclease-dicer-activity-putative-regulatory-feedback-loops-and-other-rna-mediated-mechanisms-controlling-microrna-processing
#15
Natalia Koralewska, Weronika Hoffmann, Maria Pokornowska, Marek Milewski, Andrea Lipinska, Krystyna Bienkowska-Szewczyk, Marek Figlerowicz, Anna Kurzynska-Kokorniak
Ribonuclease Dicer plays a pivotal role in RNA interference pathways by processing long double-stranded RNAs and single-stranded hairpin RNA precursors into small interfering RNAs (siRNAs) and microRNAs (miRNAs), respectively. While details of Dicer regulation by a variety of proteins are being elucidated, less is known about non-protein factors, e.g. RNA molecules, that may influence this enzyme's activity. Therefore, we decided to investigate the question of whether the RNA molecules can function not only as Dicer substrates but also as its regulators...
2016: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/27731934/the-perioperative-lung-transplant-virome-torque-teno-viruses-are-elevated-in-donor-lungs-and-show-divergent-dynamics-in-primary-graft-dysfunction
#16
A A Abbas, J M Diamond, C Chehoud, B Chang, J J Kotzin, J C Young, I Imai, A R Haas, E Cantu, D J Lederer, K Meyer, R K Milewski, K M Olthoff, A Shaked, J D Christie, F D Bushman, R G Collman
Primary graft dysfunction (PGD) is a principal cause of early morbidity and mortality after lung transplantation, but its pathogenic mechanisms are not fully clarified. Thus far, studies using standard clinical assays have not linked microbial factors to PGD. We previously used comprehensive metagenomic methods to characterize viruses in lung allografts >1 month post-transplant and found that levels of Anellovirus, mainly Torque teno viruses (TTV), were significantly higher than in non-transplant healthy controls...
October 12, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27713555/lipid-metabolism-is-associated-with-developmental-epigenetic-programming
#17
Elizabeth H Marchlewicz, Dana C Dolinoy, Lu Tang, Samantha Milewski, Tamara R Jones, Jaclyn M Goodrich, Tanu Soni, Steven E Domino, Peter X K Song, Charles F Burant, Vasantha Padmanabhan
Maternal diet and metabolism impact fetal development. Epigenetic reprogramming facilitates fetal adaptation to these in utero cues. To determine if maternal metabolite levels impact infant DNA methylation globally and at growth and development genes, we followed a clinical birth cohort of 40 mother-infant dyads. Targeted metabolomics and quantitative DNA methylation were analyzed in 1st trimester maternal plasma (M1) and delivery maternal plasma (M2) as well as infant umbilical cord blood plasma (CB). We found very long chain fatty acids, medium chain acylcarnitines, and histidine were: (1) stable in maternal plasma from pregnancy to delivery, (2) significantly correlated between M1, M2, and CB, and (3) in the top 10% of maternal metabolites correlating with infant DNA methylation, suggesting maternal metabolites associated with infant DNA methylation are tightly controlled...
October 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27666785/central-repair-with-antegrade-tevar-for-malperfusion-syndromes-in-acute-debakey-i-aortic-dissection
#18
Prashanth Vallabhajosyula, Jean Paul Gottret, Rohan Menon, Ibrahim Sultan, Zara Abbas, Mary Siki, Matthew Kramer, Aaron Pulsipher, Suveeksha Naidu, Alberto Pochettino, Kariana Milewski, Wilson Y Szeto, Joseph E Bavaria
BACKGROUND: In acute DeBakey I aortic dissection presenting with malperfusion syndromes, we assessed whether standard open repair with concomitant antegrade stent grafting (thoracic endovascular aneurysm repair; TEVAR) of the descending thoracic aorta (DTA) improves outcomes compared with standard repair alone. METHODS: From 2005 to 2012, 277 patients with acute DeBakey I dissection underwent emergent operation. Of these, 104 patients (37%) presenting with end-organ malperfusion were divided into those undergoing standard distal repair entailing transverse hemiarch replacement (Standard group, n = 65) versus standard repair with concomitant DTA TEVAR during circulatory arrest (TEVAR group, n = 39)...
September 22, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27628188/platelet-indices-in-late-preterm-newborns
#19
Wasiluk Alicja, Polewko Agnieszka, Laudanski Piotr, Redzko Slawomir, Kicel-Wesolowska Barbara, Dabrowska Milena, Milewski Robert
BACKGROUND: The current study objective was to compare blood platelet indices in late preterm newborns (LPN) and full term newborns (FTN). MATERIALS AND METHODS: We recruited 58 LPN and 71 FTN. Platelet indices were estimated in blood samples collected from the umbilical artery. RESULTS: LPN demonstrated a decreased count of blood platelets (249 × 10³/μL) as compared to FTN (295 × 10³/μL), p < 0.001. Platelet hematocrit (PCT) also showed substantial differences in both groups (LPN = 0...
October 6, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27625684/evaluation-of-safety-and-efficacy-of-nexgen-an-ultrathin-strut-and-hybrid-cell-design-cobalt-chromium-bare-metal-stent-implanted-in-a-real-life-patient-population-the-polish-nexgen-registry
#20
Krzysztof Milewski, Paweł Gąsior, Stefan Samborski, Piotr P Buszman, Aleksandra Błachut, Adam Wojtaszczyk, Adam Młodziankowski, Artur Mendyk, Marek Król, Wojciech Wojakowski, Paweł E Buszman
INTRODUCTION: Despite the dominance of drug-eluting stents in modern interventional cardiology, there is still a niche for bare metal stents. AIM: The aim of the Polish NexGen registry was to evaluate the safety and efficacy of a new generation cobalt-chromium NexGen stent in a real life patient population. MATERIAL AND METHODS: A prospective multi-center registry was conducted in five clinical sites of American Heart of Poland. Three hundred and eighty-three patients who underwent percutaneous coronary intervention (PCI) with NexGen stent implantation were included...
2016: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
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