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https://www.readbyqxmd.com/read/29784498/the-year-in-cardiothoracic-critical-care-selected-highlights-from-2017
#1
REVIEW
Jacob T Gutsche, Kamrouz Ghadimi, John G T Augoustides, Krzysztof Laudanski, Adam Evans, Menachem Weiner, Jesse Raiten, Emily Gordon, Rita Milewski, Jiri Horak, Prakash Patel, Harish Ramakrishna
No abstract text is available yet for this article.
April 10, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29738503/investigation-of-the-antifungal-activity-and-mode-of-action-of-thymus-vulgaris-citrus-limonum-pelargonium-graveolens-cinnamomum-cassia-ocimum-basilicum-and-eugenia-caryophyllus-essential-oils
#2
Katarzyna Gucwa, Sławomir Milewski, Tomasz Dymerski, Piotr Szweda
The antimicrobial activity of plant oils and extracts has been recognized for many years. In this study the activity of Thymus vulgaris , Citrus limonum , Pelargonium graveolens , Cinnamomum cassia , Ocimum basilicum , and Eugenia caryophyllus essential oils (EOs) distributed by Pollena Aroma (Nowy Dwór Mazowiecki, Poland) was investigated against a group of 183 clinical isolates of C. albicans and 76 isolates of C. glabrata . All of the oils exhibited both fungistatic and fungicidal activity toward C. albicans and C...
May 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29720149/evaluation-of-concordance-between-cad-cam-and-clinical-positions-of-abutment-shoulder-against-mucosal-margin-an-observational-study
#3
Jan K Pietruski, Anna Skurska, Anna Bernaczyk, Robert Milewski, Maria Julia Pietruska, Peter Gehrke, Małgorzata D Pietruska
BACKGROUND: While working on CAD/CAM-customized abutments, the use of standard impression copings with a circular diameter produces inconsistency within the emergence profile. It may begin with a collapse of the supra-implant mucosa during impression taking, then lead to a computer-generated mismatch of the position and outline of the abutment shoulder, and consequently result in a compromised outcome of anticipated treatment. The aim of the study was to compare the virtual and clinical positions of the abutment shoulder in relation to the mucosal margin after the abutment delivery...
May 2, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29552574/do-age-and-weightbearing-radiographs-affect-lateral-joint-space-and-fibular-height-measurements-in-patients-with-discoid-lateral-meniscus
#4
Matthew D Milewski, Ryan Krochak, Andrew J Duarte, Joseph W Marchese, Regina O Kostyun, J Lee Pace, Alexander M Broom, Matthew J Solomito
Background: Several radiographic parameters have been associated with a discoid lateral meniscus. However, limited information is available regarding the radiographic findings of a discoid meniscus in the pediatric population. Purpose: To determine the effect of age and weightbearing (WB) on radiographic parameters associated with discoid lateral menisci in pediatric patients. Study Design: Cohort study (diagnosis); Level of evidence, 3. Methods: Radiographs of pediatric patients with arthroscopically confirmed lateral discoid menisci were compared with age-, side-, and sex-matched individuals with confirmed normal menisci...
March 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29534191/immunoproteasome-in-the-plasma-of-paediatric-patients-with-moderate-and-major-burns-and-its-correlation-with-proteasome-and-uchl1-measured-by-spr-imaging-biosensors
#5
Ewa Matuszczak, Artur Weremijewicz, Marta Komarowska, Anna Sankiewicz, Diana Markowska, Wojciech Debek, Ewa Gorodkiewicz, Robert Milewski, Adam Hermanowicz
THE AIM: to determinate the immunoproteasome concentration in blood plasma of paediatric patients with moderate and major burns, and its correlation with circulating proteasome and UCHL1 with SPRI biosensor. MATERIAL AND METHODS: The study population comprised 30 patients with moderate (n=21), and severe burns (n=9), aged 9 months to 14 years. The control group represented 18 healthy, age matched patients, admitted for herniotomy. Exclusion criteria were: admission to the hospital later than 6 hours after burn, cardiovascular or immunological diseases, and severe preexisting infections...
March 9, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29525032/pediatric-sports-medicine-injuries-common-problems-and-solutions
#6
REVIEW
Joel B Huleatt, Carl W Nissen, Matthew D Milewski
The treatment of sports injuries in the skeletally immature has a unique set of complications. Growth deformity may occur after anterior cruciate ligament reconstruction; therefore, skeletal age is used to help guide the choice between physeal sparing and transphyseal techniques. Arthrofibrosis after tibial spine fracture fixation can be reduced by initiating immediate range of motion, and should be treated early and cautiously to avoid iatrogenic fracture. Nonunions of medial epicondyle elbow fractures are more common with nonoperative treatment, but seldom lead to clinical problems outside of certain athletes...
April 2018: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/29497620/anterior-cruciate-ligament-reconstruction-in-skeletally-immature-patients-early-results-using-a-hybrid-physeal-sparing-technique
#7
Robert G Willson, Regina O Kostyun, Matthew D Milewski, Carl W Nissen
Background: Reconstruction of the anterior cruciate ligament (ACL) in the skeletally immature patient is frequently performed in hopes of preventing new or additional chondral damage and meniscal injuries. Patients within a few years of skeletal maturity are more at risk for ACL injuries than prepubescent patients, about whom several physeal-sparing techniques have been described. Reconstruction techniques in the former higher risk group need to be better understood. Purpose: To review a series of adolescent patients with ACL injuries surgically treated with the hybrid physeal-sparing technique...
February 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29485855/molecular-umbrellas-modulate-the-selective-toxicity-of-polyene-macrolide-antifungals
#8
Andrzej S Skwarecki, Kornelia Skarbek, Dorota Martynow, Marcin Serocki, Irena Bylińska, Maria J Milewska, Sławomir Milewski
Antifungal polyene macrolide antibiotics Amphotericin B (AmB) and Nystatin (NYS) were conjugated through the ω-amino acid linkers with diwalled "molecular umbrellas" composed of spermidine-linked deoxycholic or cholic acids. The presence of "umbrella" substituents modulated biological properties of the antibiotics, especially their selective toxicity. Some of the AmB-umbrella conjugates demonstrated antifungal in vitro activity comparable to that of the mother antibiotic but diminished mammalian toxicity, especially the hemolytic activity...
April 18, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29473851/fast-and-simple-analytical-method-for-direct-determination-of-total-chlorine-content-in-polyglycerol-by-icp-ms
#9
Agata Jakóbik-Kolon, Andrzej Milewski, Piotr Dydo, Magdalena Witczak, Joanna Bok-Badura
The fast and simple method for total chlorine determination in polyglycerols using low resolution inductively coupled plasma mass spectrometry (ICP-MS) without the need for additional equipment and time-consuming sample decomposition was evaluated. Linear calibration curve for 35 Cl isotope in the concentration range 20-800 µg/L was observed. Limits of detection and quantification equaled to 15 µg/L and 44 µg/L, respectively. This corresponds to possibility of detection 3 µg/g and determination 9 µg/g of chlorine in polyglycerol using studied conditions (0...
February 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29395557/all-epiphyseal-anterior-cruciate-ligament-femoral-tunnel-drilling-avoiding-injury-to-the-physis-lateral-collateral-ligament-anterolateral-ligament-and-popliteus-a-3-dimensional-computed-tomography-study
#10
Kevin G Shea, Peter C Cannamela, Peter D Fabricant, Elizabeth B Terhune, John D Polousky, Matthew D Milewski, Allen F Anderson, Theodore J Ganley
PURPOSE: To investigate the relation of the at-risk structures (distal femoral physis, lateral collateral ligament, anterolateral ligament, popliteus, and articular cartilage) during all-epiphyseal femoral tunnel drilling. A second purpose was 2-fold: (1) to develop recommendations for tunnel placement and orientation that anatomically reconstruct the anterior cruciate ligament (ACL) while minimizing the risk of injury to these at-risk structures, and (2) to allow for maximal tunnel length to increase the amount of graft in the socket to facilitate healing...
January 25, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29345684/msh6-and-pms2-germ-line-pathogenic-variants-implicated-in-lynch-syndrome-are-associated-with-breast-cancer
#11
Maegan E Roberts, Sarah A Jackson, Lisa R Susswein, Nur Zeinomar, Xinran Ma, Megan L Marshall, Amy R Stettner, Becky Milewski, Zhixiong Xu, Benjamin D Solomon, Mary Beth Terry, Kathleen S Hruska, Rachel T Klein, Wendy K Chung
PurposeAn association of Lynch syndrome (LS) with breast cancer has been long suspected; however, there have been insufficient data to address this question for each of the LS genes individually.MethodsWe conducted a retrospective review of personal and family history in 423 women with pathogenic or likely pathogenic germ-line variants in MLH1 (N = 65), MSH2 (N = 94), MSH6 (N = 140), or PMS2 (N = 124) identified via clinical multigene hereditary cancer testing. Standard incidence ratios (SIRs) of breast cancer were calculated by comparing breast cancer frequencies in our study population with those in the general population (Surveillance, Epidemiology, and End Results 18 data)...
January 18, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29322651/antifungal-dipeptides-incorporating-an-inhibitor-of-homoserine-dehydrogenase
#12
Andrzej S Skwarecki, Marta Schielmann, Dorota Martynow, Marcin Kawczyński, Aleksandra Wiśniewska, Maria J Milewska, Sławomir Milewski
The antifungal activity of 5-hydroxy-4-oxo-l-norvaline (HONV), exhibited under conditions mimicking human serum, may be improved upon incorporation of this amino acid into a dipeptide structure. Several HONV-containing dipeptides inhibited growth of human pathogenic yeasts of the Candida genus in the RPMI-1640 medium, with minimal inhibitory concentration values in the 32 to 64 μg mL-1 range. This activity was not affected by multidrug resistance that is caused by overexpression of genes encoding drug efflux proteins...
January 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29318898/path-planning-for-minimally-invasive-knee-surgery-using-a-hybrid-optimization-procedure
#13
Adam Ciszkiewicz, Grzegorz Milewski
The aim of this study was to develop a procedure for medical tool path planning in minimally-invasive knee surgery. The collision-free paths for the tool were obtained using the control locations method with a hybrid optimization strategy. The tool and knee elements were described with surface meshes. The knee model allowed for bones displacement and variable incision size and location. The proposed procedure was proven to be effective in path planning for minimally-invasive surgery. It can serve as a valuable aid in surgery planning and may also be used in systems for autonomous or semi-autonomous knee surgery...
January 2018: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/29316179/a-novel-planning-solution-for-semi-autonomous-aspiration-of-baker-s-cysts
#14
Adam Ciszkiewicz, Jacek Lorkowski, Grzegorz Milewski
BACKGROUND: A Baker's cyst is a pathological structure located near a kneepit, which causes discomfort and reduces mobility of the knee. It is commonly treated with aspiration, which often requires MRI scanning and US guidance. The aim of this study was to propose a novel planning solution for semi-autonomous aspiration of the Baker's cyst using only MRI imaging. METHODS: The proposed method requires minimal user input and offers automatic cyst segmentation with collision-free path planning for the assumed robotic structure with four degrees of freedom...
April 2018: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29302181/medical-students-attitudes-toward-torture-revisited
#15
Krista Dubin, Andrew R Milewski, Joseph Shin, Thomas P Kalman
This paper reports the findings of a survey of medical students' attitudes toward torture and discusses variables that may correlate with those attitudes. In late 2016, 483 enrolled medical and MD-PhD students at the Weill Cornell Medical College received an anonymous, institutional review board-approved survey that included questions about torture and its effectiveness, demographic questions, inquiries about personal experiences of harassment or discrimination, and questions regarding engagement in human rights activities...
December 2017: Health and Human Rights
https://www.readbyqxmd.com/read/29286103/gene-expression-profiling-of-acute-myeloid-leukemia-samples-from-adult-patients-with-aml-m1-and-m2-through-boutique-microarrays-real-time-pcr-and-droplet-digital-pcr
#16
Luiza Handschuh, Maciej Kaźmierczak, Marek C Milewski, Michał Góralski, Magdalena Łuczak, Marzena Wojtaszewska, Barbara Uszczyńska-Ratajczak, Krzysztof Lewandowski, Mieczysław Komarnicki, Marek Figlerowicz
Acute myeloid leukemia (AML) is the most common and severe form of acute leukemia diagnosed in adults. Owing to its heterogeneity, AML is divided into classes associated with different treatment outcomes and specific gene expression profiles. Based on previous studies on AML, in this study, we designed and generated an AML-array containing 900 oligonucleotide probes complementary to human genes implicated in hematopoietic cell differentiation and maturation, proliferation, apoptosis and leukemic transformation...
March 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29282483/soluble-trem-1-serum-level-can-early-predict-mortality-of-patients-with-sepsis-severe-sepsis-and-septic-shock
#17
Monika Jedynak, Andrzej Siemiatkowski, Barbara Mroczko, Magdalena Groblewska, Robert Milewski, Maciej Szmitkowski
Early prognostic prediction of sepsis is essential in adjusting therapeutic protocols to prevent deterioration and reduce mortality. We compared the predictive value of the serum concentration of the soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) for 28-day mortality and for the development of severe sepsis or septic shock on the third day with the levels of interleukin (IL)-6, C-reactive protein (CRP) and procalcitonin (PCT). The study was conducted on 85 patients with sepsis. sTREM-1, CRP, PCT and IL-6 concentrations were measured upon study inclusion (day 0) and on days 1, 2, 3 and 5...
December 27, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29244688/arthrofibrosis-associated-with-the-surgical-treatment-of-chronic-lyme-arthritis-and-a-concomitant-medial-meniscal-tear-a-case-report
#18
Nathanael Tran, Matthew D Milewski
CASE: We describe a case of refractory Lyme arthritis in an adolescent patient with a concomitant medial meniscal tear. The patient underwent arthroscopic synovectomy and meniscal repair, and required additional surgery for subsequent decreased range of motion. We describe the presentation, the intraoperative findings, the course of recovery, and the literature regarding Lyme arthritis and meniscal tears. CONCLUSION: Refractory Lyme arthritis commonly is treated successfully with arthroscopic synovectomy...
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29234882/the-impact-of-hla-g-lilrb1-and-lilrb2-gene-polymorphisms-on-susceptibility-to-and-severity-of-endometriosis
#19
Aleksandra Bylińska, Karolina Wilczyńska, Jacek Malejczyk, Łukasz Milewski, Marta Wagner, Monika Jasek, Wanda Niepiekło-Miniewska, Andrzej Wiśniewski, Rafał Płoski, Ewa Barcz, Piotr Roszkowski, Paweł Kamiński, Andrzej Malinowski, Jacek R Wilczyński, Paweł Radwan, Michał Radwan, Piotr Kuśnierczyk, Izabela Nowak
Endometriosis is a disease in which endometriotic tissue occurs outside the uterus. Its pathogenesis is still unknown. The most widespread hypothesis claims that ectopic endometrium appears as a result of retrograde menstruation and its insufficient elimination by immunocytes. Some reports have shown expression of non-classical HLA-G molecules on ectopic endometrium. HLA-G is recognized by KIR2DL4, LILRB1 and LILRB2 receptors on natural killer (NK) and other cells. These receptors are polymorphic, which may affect their activity...
December 12, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29203070/a-sirolimus-eluting-bioabsorbable-polymer-coated-stent-mistent-versus-an-everolimus-eluting-durable-polymer-stent-xience-after-percutaneous-coronary-intervention-dessolve-iii-a-randomised-single-blind-multicentre-non-inferiority-phase-3-trial
#20
Robbert J de Winter, Yuki Katagiri, Taku Asano, Krzysztof P Milewski, Philipp Lurz, Pawel Buszman, Gillian A J Jessurun, Karel T Koch, Roland P T Troquay, Bas J B Hamer, Ton Oude Ophuis, Jochen Wöhrle, Rafał Wyderka, Guillaume Cayla, Sjoerd H Hofma, Sébastien Levesque, Aleksander Żurakowski, Dieter Fischer, Maciej Kośmider, Pascal Goube, E Karin Arkenbout, Michel Noutsias, Markus W Ferrari, Yoshinobu Onuma, William Wijns, Patrick W Serruys
BACKGROUND: MiStent is a drug-eluting stent with a fully absorbable polymer coating containing and embedding a microcrystalline form of sirolimus into the vessel wall. It was developed to overcome the limitation of current durable polymer drug-eluting stents eluting amorphous sirolimus. The clinical effect of MiStent sirolimus-eluting stent compared with a durable polymer drug-eluting stents has not been investigated in a large randomised trial in an all-comer population. METHODS: We did a randomised, single-blind, multicentre, phase 3 study (DESSOLVE III) at 20 hospitals in Germany, France, Netherlands, and Poland...
February 3, 2018: Lancet
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