Martina Zafferani, Christina Haddad, Le Luo, Jesse Davila-Calderon, Liang Yuan-Chiu, Christian Shema Mugisha, Adeline G Monaghan, Andrew A Kennedy, Joseph D Yesselman, Robert R Gifford, Andrew W Tai, Sebla B Kutluay, Mei-Ling Li, Gary Brewer, Blanton S Tolbert, Amanda E Hargrove
The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics, has rendered our understanding of coronavirus biology more essential than ever. Small molecule chemical probes offer to both reveal novel aspects of virus replication and to serve as leads for antiviral therapeutic development. The RNA-biased amiloride scaffold was recently tuned to target a viral RNA structure critical for translation in enterovirus 71, ultimately uncovering a novel mechanism to modulate positive-sense RNA viral translation and replication...
December 6, 2020: bioRxiv