Read by QxMD icon Read

C Hargrove

Sandra C Bishop-Freeman, Marc S Feaster, Jennifer Beal, Alison Miller, Robert L Hargrove, Justin O Brower, Ruth E Winecker
Loperamide (Imodium(®)) has been accepted as a safe, effective, over-the-counter anti-diarrheal drug with low potential for abuse. It is a synthetic opioid that lacks central nervous system activity at prescribed doses, rendering it ineffective for abuse. Since 2012, however, the North Carolina Office of the Chief Medical Examiner has seen cases involving loperamide at supratherapeutic levels that indicate abuse. The recommended dose associated with loperamide should not exceed 16 mg per day, although users seeking an opioid-like high reportedly take it in excess of 100 mg per dose...
October 2016: Journal of Analytical Toxicology
Virginia B Kraus, David E Hargrove, David J Hunter, Jordan B Renner, Joanne M Jordan
OBJECTIVE: To establish reference intervals for osteoarthritis (OA)-related biomarkers used in the Foundation for the National Institutes of Health (FNIH) OA Biomarkers Consortium Project. METHODS: A total of 129 'multijoint controls' were selected from 2722 African-American and Caucasian men and women in the Johnston County Osteoarthritis Project. The majority (79%) of those eligible (with biospecimens and baseline data) also had one or more follow-up evaluations 5-15 years later...
June 24, 2016: Annals of the Rheumatic Diseases
George J Arnaoutakis, Prashanth Vallabhajosyula, Joseph E Bavaria, Ibrahim Sultan, Mary Siki, Suveeksha Naidu, Rita K Milewski, Matthew L Williams, W Clark Hargrove, Nimesh D Desai, Wilson Y Szeto
BACKGROUND: There remains concern that moderate hypothermic circulatory arrest (MHCA) with antegrade cerebral perfusion (ACP) may provide suboptimal distal organ protection compared with deep hypothermic circulatory arrest (DHCA) with retrograde cerebral perfusion (RCP). We compared postoperative acute kidney injury (AKI) in in patients who underwent elective hemiarch repair with either DHCA/RCP or MHCA/ACP. METHODS: This was a retrospective review of all patients undergoing elective aortic hemiarch reconstruction for aneurysmal disease between 2009 and 2014...
October 2016: Annals of Thoracic Surgery
Virginia Byers Kraus, Jamie E Collins, David Hargrove, Elena Losina, Michael Nevitt, Jeffrey N Katz, Susanne X Wang, Linda J Sandell, Steven C Hoffmann, David J Hunter
OBJECTIVE: To investigate a targeted set of biochemical biomarkers as predictors of clinically relevant osteoarthritis (OA) progression. METHODS: Eighteen biomarkers were measured at baseline, 12 months (M) and 24 M in serum (s) and/or urine (u) of cases (n=194) from the OA initiative cohort with knee OA and radiographic and persistent pain worsening from 24 to 48 M and controls (n=406) not meeting both end point criteria. Primary analyses used multivariable regression models to evaluate the association between biomarkers (baseline and time-integrated concentrations (TICs) over 12 and 24 M, transposed to z values) and case status, adjusted for age, sex, body mass index, race, baseline radiographic joint space width, Kellgren-Lawrence grade, pain and pain medication use...
June 13, 2016: Annals of the Rheumatic Diseases
Carolyn J Winslow, Seth A Kaplan, Jill C Bradley-Geist, Alex P Lindsey, Afra S Ahmad, Amber K Hargrove
Owing to the importance of employee psychological well-being for a variety of work- and non-work-related outcomes, practitioners and scholars have begun to broaden the scope of workplace well-being interventions by incorporating principles from positive psychology. Among such positive interventions, gratitude exercises have arguably emerged as the "gold standard" practice, with much research pointing to their effectiveness. However, existing workplace interventions lack a true (i.e., no intervention) control group, and effects have been observed for some-but not all-outcomes tested...
April 21, 2016: Journal of Occupational Health Psychology
Kathleen C M Campbell, Seth M Martin, Robert P Meech, Tim L Hargrove, Steven J Verhulst, Daniel J Fox
OBJECTIVE: Test D-methionine (D-met) as an otoprotectant from kanamycin-induced ototoxicity and determine the lowest maximally protective D-met dose. DESIGN: Auditory brainstem responses (ABR) were measured at 4, 8, 14, and 20 kHz at baseline and two, four, and six weeks after kanamycin and D-met administration initiation. ABR threshold shifts assessed auditory function. Following six-week ABR testing, animals were decapitated and cochleae collected for outer hair cell (OHC) quantification...
2016: International Journal of Audiology
L R Benedetti, J P Holder, M Perkins, C G Brown, C S Anderson, F V Allen, R B Petre, D Hargrove, S M Glenn, N Simanovskaia, D K Bradley, P Bell
We describe an experimental method to measure the gate profile of an x-ray framing camera and to determine several important functional parameters: relative gain (between strips), relative gain droop (within each strip), gate propagation velocity, gate width, and actual inter-strip timing. Several of these parameters cannot be measured accurately by any other technique. This method is then used to document cross talk-induced gain variations and artifacts created by radiation that arrives before the framing camera is actively amplifying x-rays...
February 2016: Review of Scientific Instruments
Arminder S Jassar, Prashanth Vallabhajosyula, Joseph E Bavaria, Jacob Gutsche, Nimesh D Desai, Matthew L Williams, Rita K Milewski, W Clark Hargrove, Wilson Y Szeto
OBJECTIVE: We describe an alternate technique for establishing antegrade cerebral perfusion (ACP) during hypothermic circulatory arrest via direct, central cannulation of the innominate artery. METHODS: From 2009 to 2015, 100 elective hemiarch reconstructions for proximal aortic aneurysms were performed under moderate hypothermic circulatory arrest (MHCA). Cerebral perfusion was instituted with ACP via direct cannulation of the innominate artery. RESULTS: Mean patient age was 63 ± 13 years (72 men; 72%)...
April 2016: Journal of Thoracic and Cardiovascular Surgery
William J Hoekstra, Tatiana Y Hargrove, Zdzislaw Wawrzak, Denise da Gama Jaen Batista, Cristiane F da Silva, Aline S G Nefertiti, Girish Rachakonda, Robert J Schotzinger, Fernando Villalta, Maria de Nazaré C Soeiro, Galina I Lepesheva
A novel antifungal drug candidate, the 1-tetrazole-based agent VT-1161 [(R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}propan-2-ol], which is currently in two phase 2b antifungal clinical trials, was found to be a tight-binding ligand (apparent dissociation constant [Kd], 24 nM) and a potent inhibitor of cytochrome P450 sterol 14α-demethylase (CYP51) from the protozoan pathogen Trypanosoma cruzi. Moreover, VT-1161 revealed a high level of antiparasitic activity against amastigotes of the Tulahuen strain of T...
February 2016: Antimicrobial Agents and Chemotherapy
Christopher Johnson, Victoria Huynh, Laura Hargrove, Lindsey Kennedy, Allyson Graf-Eaton, Jennifer Owens, Jerome P Trzeciakowski, Kyle Hodges, Sharon DeMorrow, Yuyan Han, Lucas Wong, Gianfranco Alpini, Heather Francis
The tumor microenvironment of cholangiocarcinoma (CCA) is composed of numerous cells, including mast cells (MCs). MCs release histamine, which increases CCA progression and angiogenesis. Cholangiocytes secrete stem cell factor, which functions via the MC growth factor receptor c-Kit. Here, we show that cholangiocytes express histidine decarboxylase and its inhibition reduces CCA growth. MC recruitment in the tumor microenvironment increased CCA growth. MC infiltration and MC markers were detected by toluidine blue staining and real-time PCR in human biopsies and in tumors from athymic mice treated with saline, histamine, histidine decarboxylase inhibitor, or cromolyn sodium...
January 2016: American Journal of Pathology
Kayla C LeSage, Emily C Hargrove, Jesse L Cahill, Eric S Rasche, Gabriel F Kuty Everett
Bacteriophage Merlin is a T4-like myophage which infects Citrobacter freundii, a member of the Enterobacteriaceae family. C. freundii is an opportunistic pathogen that is a common cause of nosocomial infections. This report announces the complete genome of myophage Merlin and describes its features.
2015: Genome Announcements
Tatiana Y Hargrove, Zdzislaw Wawrzak, David C Lamb, F Peter Guengerich, Galina I Lepesheva
Aspergillus fumigatus is the opportunistic fungal pathogen that predominantly affects the immunocompromised population and causes 600,000 deaths/year. The cytochrome P450 51 (CYP51) inhibitor voriconazole is currently the drug of choice, yet the treatment efficiency remains low, calling for rational development of more efficient agents. A. fumigatus has two CYP51 genes, CYP51A and CYP51B, which share 59% amino acid sequence identity. CYP51B is expressed constitutively, whereas gene CYP51A is reported to be inducible...
September 25, 2015: Journal of Biological Chemistry
Daniel J Fox, Morris D Cooper, Cristian A Speil, Melissa H Roberts, Susan C Yanik, Robert P Meech, Tim L Hargrove, Steven J Verhulst, Leonard P Rybak, Kathleen C M Campbell
BACKGROUND: Tobramycin is a critical cystic fibrosis treatment however it causes ototoxicity. This study tested d-methionine protection from tobramycin-induced ototoxicity and potential antimicrobial interference. METHODS: Auditory brainstem responses (ABRs) and outer hair cell (OHC) quantifications measured protection in guinea pigs treated with tobramycin and a range of d-methionine doses. In vitro antimicrobial interference studies tested inhibition and post antibiotic effect assays...
July 2016: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Emily C Hargrove, Mariana S Lopez, Adriana C Hernandez, Gabriel F Kuty Everett
Bacillus megaterium has been widely used as a research tool for decades. Its use is on the rise as a recombinant protein production host and as a bioremediation bacterium. Bacteriophages against this bacterium may have biotechnological applications. Here, we describe the novel podophage Palmer, which infects B. megaterium.
2015: Genome Announcements
William L Hargrove, Patricia M Juárez-Carillo, Marcelo Korc
We conducted a Health Impact Assessment (HIA) focused on water and sanitation in Vinton, TX, a small rural town on the U.S./Mexico Border. We present the Vinton HIA as a case study to inform the practice of HIA in rural limited resource communities with higher than average levels of unemployment and poverty, and limited infrastructure. Household surveys, focus groups, and interviews provided quantitative and qualitative data on water sources and quality, sanitation practices, and community health. We found that some of the current water sources in Vinton did not meet drinking water standards for total dissolved solids and arsenic; the majority of septic tanks were not managed properly; and there was a short-term risk of water scarcity due to prolonged drought in the region...
April 2015: International Journal of Environmental Research and Public Health
Prashanth Vallabhajosyula, Arminder S Jassar, Rohan S Menon, Caroline Komlo, Jacob Gutsche, Nimesh D Desai, W Clark Hargrove, Joseph E Bavaria, Wilson Y Szeto
BACKGROUND: Deep hypothermic circulatory arrest (DHCA) with retrograde cerebral perfusion (DHCA group) has traditionally been the cerebral protection strategy during transverse hemiarch aortic reconstruction. Recently, we have adopted moderate hypothermic (≥ 25 °C) circulatory arrest (MHCA) with antegrade cerebral perfusion (MHCA group). We compared the outcomes for these two circulatory arrest management strategies. METHODS: From 2008 to 2012, in a concurrent series of 376 patients (DHCA, 301; MHCA, 75) undergoing transverse hemiarch for aortic aneurysm disease, incidences of concomitant root replacement (44% vs 47%, p = 0...
May 2015: Annals of Thoracic Surgery
John W Hargrove, M Odwell Muzari
BACKGROUND: The biology of adult tsetse (Glossina spp), vectors of trypanosomiasis in Africa, has been extensively studied - but little is known about larviposition in the field. METHODOLOGY/PRINCIPAL FINDINGS: In September-November 1998, in the hot-dry season in Zimbabwe's Zambezi Valley, we used artificial warthog burrows to capture adult females as they deposited larvae. Females were subjected to ovarian dissection and were defined as perinatal flies, assumed to have entered burrows to larviposit, if oocyte sizes indicated >95% pregnancy completion...
March 2015: PLoS Neglected Tropical Diseases
Lauren C Harte-Hargrove, Ada Varga-Wesson, Aine M Duffy, Teresa A Milner, Helen E Scharfman
The mossy fiber (MF) pathway is critical to hippocampal function and influenced by gonadal hormones. Physiological data are limited, so we asked whether basal transmission and long-term potentiation (LTP) differed in slices of adult male and female rats. The results showed small sex differences in basal transmission but striking sex differences in opioid receptor sensitivity and LTP. When slices were made from females on proestrous morning, when serum levels of 17β-estradiol peak, the nonspecific opioid receptor antagonist naloxone (1 μm) enhanced MF transmission but there was no effect in males, suggesting preferential opioid receptor-dependent inhibition in females when 17β-estradiol levels are elevated...
January 28, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
N Izumi, G N Hall, A C Carpenter, F V Allen, J G Cruz, B Felker, D Hargrove, J Holder, J D Kilkenny, A Lumbard, R Montesanti, N E Palmer, K Piston, G Stone, M Thao, R Vern, R Zacharias, O L Landen, R Tommasini, D K Bradley, P M Bell
Recently developed diagnostic techniques at LLNL require recording backlit images of extremely dense imploded plasmas using hard x-rays, and demand the detector to be sensitive to photons with energies higher than 50 keV [R. Tommasini et al., Phys. Phys. Plasmas 18, 056309 (2011); G. N. Hall et al., "AXIS: An instrument for imaging Compton radiographs using ARC on the NIF," Rev. Sci. Instrum. (these proceedings)]. To increase the sensitivity in the high energy region, we propose to use a combination of two MCPs...
November 2014: Review of Scientific Instruments
Lindsey L Kennedy, Laura A Hargrove, Allyson B Graf, Taylor C Francis, Kyle M Hodges, Quy P Nguyen, Yoshi Ueno, John F Greene, Fanyin Meng, Victoria D Huynh, Heather L Francis
Cholangiopathies are characterized by dysregulation of the balance between biliary growth and loss. We have shown that histamine (HA) stimulates biliary growth via autocrine mechanisms. To evaluate the paracrine effects of mast cell (MC) stabilization on biliary proliferation, sham or BDL rats were treated by IP-implanted osmotic pumps filled with saline or cromolyn sodium (24 mg/kg BW/day (inhibits MC histamine release)) for 1 week. Serum, liver blocks and cholangiocytes were collected. Histidine decarboxylase (HDC) expression was measured using real-time PCR in cholangiocytes...
December 2014: Laboratory Investigation; a Journal of Technical Methods and Pathology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"