keyword
MENU ▼
Read by QxMD icon Read
search

Laslett

keyword
https://www.readbyqxmd.com/read/29621741/harm-from-others-drinking-related-aggression-violence-and-misconduct-in-five-asian-countries-and-the-implications
#1
Orratai Waleewong, Anne-Marie Laslett, Richard Chenhall, Robin Room
BACKGROUND: Harm from alcohol-attributable aggression and violence is linked to diminished personal safety and reduced physical and mental health and wellbeing in many countries. But there has been limited evidence on these harms in low- and middle-income countries (LMICs). This study measured harm from others' drinking-related aggression, violence and misconduct in five Asian LMICs (Thailand, Sri Lanka, India, Vietnam, and Lao PDR), aiming to compare the magnitude and pattern of harm across countries by gender, age group, educational level, rurality, and country-level indicators...
April 2, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29543848/physiological-oxygen-culture-reveals-retention-of-metabolic-memory-in-human-induced-pluripotent-stem-cells
#2
Alexandra J Harvey, Carmel O'Brien, Jack Lambshead, John R Sheedy, Joy Rathjen, Andrew L Laslett, David K Gardner
Reprogramming somatic cells to a pluripotent cell state (induced Pluripotent Stem (iPS) cells) requires reprogramming of metabolism to support cell proliferation and pluripotency, most notably changes in carbohydrate turnover that reflect a shift from oxidative to glycolytic metabolism. Some aspects of iPS cell metabolism differ from embryonic stem (ES) cells, which may reflect a parental cell memory, or be a consequence of the reprogramming process. In this study, we compared the metabolism of 3 human iPS cell lines to assess the fidelity of metabolic reprogramming...
2018: PloS One
https://www.readbyqxmd.com/read/29524873/child-injury-deaths-linked-with-adult-alcohol-consumption-a-time-series-analysis
#3
Anne-Marie Laslett, Heng Jiang, Tanya Chikritzhs
OBJECTIVE: This paper aims to quantify the population-level associations between child injury deaths and adult (aged 15+ years) per capita alcohol consumption (PCC) and between child injury deaths and the impact of major alcohol and safety policy changes in Australia. METHODS: All child deaths due to external causes during 1910-2013, and child deaths due specifically to road crashes, assaults, suicide and other external causes, were obtained from the Australian Institute of Health and Welfare...
January 31, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29499287/a-randomised-double-blind-placebo-controlled-crossover-trial-of-humira-adalimumab-for-erosive-hand-osteoarthritis-the-humor-trial
#4
Dawn Aitken, Laura L Laslett, Feng Pan, Ida K Haugen, Petr Otahal, Nicholas Bellamy, Paul Bird, Graeme Jones
OBJECTIVE: To assess the efficacy of adalimumab in patients with erosive hand osteoarthritis (OA). METHOD: Patients >50 years old, meeting the ACR criteria for hand OA, with pain >50 on 100mm VAS, morning stiffness >30 minutes and >1 erosive joint on x-ray with synovitis present on MRI were included in a randomised double-blind placebo-controlled crossover trial. Patients were randomised to adalimumab (40 mg subcutaneous injections every other week) or identical placebo injections for 12 weeks followed by an 8-week washout and then crossed over treatment groups for another 12 weeks...
February 27, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29441423/how-do-mri-detected-subchondral-bone-marrow-lesions-bmls-on-two-different-mri-sequences-correlate-with-clinically-important-outcomes
#5
Siti Maisarah Mattap, Dawn Aitken, Karen Wills, Laura Laslett, Changhai Ding, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Stephen E Graves, Michelle Lorimer, Flavia Cicuttini, Graeme Jones
The aim of this study is to describe the association of bone marrow lesions (BMLs) present on two different MRI sequences with clinical outcomes, cartilage defect progression, cartilage volume loss over 2.7 years, and total knee replacement (TKR) over 13.3 years. 394 participants (50-80 years) were assessed at baseline and 2.7 years. BML presence at baseline was scored on T1-weighted fat-suppressed 3D gradient-recalled acquisition (T1) and T2-weighted fat-suppressed 2D fast spin-echo (T2) sequences. Knee pain, function, and stiffness were assessed using WOMAC...
February 13, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29335618/long-term-maintenance-of-human-pluripotent-stem-cells-on-crgdfk-presenting-synthetic-surfaces
#6
Jack W Lambshead, Laurence Meagher, Jacob Goodwin, Tanya Labonne, Elizabeth Ng, Andrew Elefanty, Edouard Stanley, Carmel M O'Brien, Andrew L Laslett
Synthetic human pluripotent stem cell (hPSC) culture surfaces with defined physical and chemical properties will facilitate improved research and therapeutic applications of hPSCs. In this study, synthetic surfaces for hPSC culture in E8 medium were produced for screening by modifying two polymer brush coatings [poly(acrylamide-co-acrylic acid) (PAAA) and poly(acrylamide-co-propargyl acrylamide) (PAPA)] to present single peptides. Adhesion of hPSC colonies was more consistently observed on surfaces modified with cRGDfK compared to surfaces modified with other peptide sequences tested...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29297602/effect-of-zoledronic-acid-and-denosumab-in-patients-with-low-back-pain-and-modic-change-a-proof-of-principle-trial
#7
Guoqi Cai, Laura L Laslett, Dawn Aitken, Andrew Halliday, Feng Pan, Petr Otahal, Deborah Speden, Tania M Winzenberg, Graeme Jones
The aim of this study was to evaluate the effect of zoledronic acid (ZA) and denosumab on low back pain (LBP) and Modic change (MC) over 6 months. Adults aged ≥40 years with significant LBP for at least 6 months duration and MC (type 1, 2, or mixed) were randomized to receive ZA (5 mg/100 mL), denosumab (60 mg), or placebo. LBP was measured monthly by visual analogue scale (VAS) and the LBP Rating Scale (RS). MC was measured from MRIs of T12 -S1 vertebrae at screening and 6 months. A total of 103 participants with moderate/severe LBP (mean VAS = 57 mm; mean RS = 18) and median total MC area 538 mm2 were enrolled...
January 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29246678/individualized-fracture-risk-feedback-and-long-term-benefits-after-10-years
#8
Feitong Wu, Karen Wills, Laura L Laslett, Malcolm D Riley, Brian Oldenburg, Graeme Jones, Tania Winzenberg
INTRODUCTION: This study aimed to determine if beneficial effects of individualized feedback of fracture risk on osteoporosis preventive behaviors and bone mineral density observed in a 2-year trial were sustained long-term. METHODS: This was a 10-year follow-up of a 2-year RCT in 470 premenopausal women aged 25-44 years, who were randomized to one of two educational interventions (the Osteoporosis Prevention and Self-Management Course [OPSMC] or an osteoporosis information leaflet) and received tailored feedback of their relative risk of fracture in later life (high versus normal risk groups)...
February 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29227830/cell-surface-markers-for-the-identification-and-study-of-human-naive-pluripotent-stem-cells
#9
REVIEW
Oliver Trusler, Ziyi Huang, Jacob Goodwin, Andrew L Laslett
Characterisation of mouse pluripotent stem cells has revealed two distinct pluripotent states, naive and primed, that maintain characteristics of the pre and post implanted epiblast respectively. Recent studies have developed several culture systems that seek to recapitulate the naive phenomenon in human pluripotent stem cells. Therefore, robust methods to isolate these cells will be fundamental to assess their potential in modelling human development and disease. Here we review current methods for human naive pluripotent culture and collate a list of cell surface antigens that have been identified as markers to differentiate naive from primed human pluripotent stem cells...
December 2, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29178662/addiction-research-centres-and-the-nurturing-of-creativity-the-centre-for-alcohol-policy-research-capr-melbourne-a-decade-on
#10
Claire Wilkinson, Amy Pennay, Sarah MacLean, Michael Livingston, Robin Room, Margaret Hamilton, Anne-Marie Laslett, Heng Jiang, Sarah Callinan, Orratai Waleewong
Established in 2006, the Centre for Alcohol Policy Research (CAPR) is Australia's only research centre with a primary focus on alcohol policy. CAPR has four main areas of research: alcohol policy impacts; alcohol policy formation and regulatory processes involved in implementing alcohol policies; patterns and trends in drinking and alcohol problems in the population; and the influence of drinking norms, cultural practices and social contexts, particularly in interaction with alcohol policies. In this paper, we give examples of key publications in each area...
March 2018: Addiction
https://www.readbyqxmd.com/read/29155560/asymmetric-assembling-of-iron-oxide-nanocubes-for-improving-magnetic-hyperthermia-performance
#11
Dina Niculaes, Aidin Lak, George C Anyfantis, Sergio Marras, Oliver Laslett, Sahitya K Avugadda, Marco Cassani, David Serantes, Ondrej Hovorka, Roy Chantrell, Teresa Pellegrino
Magnetic hyperthermia (MH) based on magnetic nanoparticles (MNPs) is a promising adjuvant therapy for cancer treatment. Particle clustering leading to complex magnetic interactions affects the heat generated by MNPs during MH. The heat efficiencies, theoretically predicted, are still poorly understood because of a lack of control of the fabrication of such clusters with defined geometries and thus their functionality. This study aims to correlate the heating efficiency under MH of individually coated iron oxide nanocubes (IONCs) versus soft colloidal nanoclusters made of small groupings of nanocubes arranged in different geometries...
December 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28990541/associations-of-dietary-patterns-with-bone-mass-muscle-strength-and-balance-in-a-cohort-of-australian-middle-aged-women
#12
Feitong Wu, Karen Wills, Laura L Laslett, Brian Oldenburg, Graeme Jones, Tania Winzenberg
Influences of dietary patterns on musculoskeletal health are poorly understood in middle-aged women. This cross-sectional analysis from a cohort of 347 women (aged 36-57 years) aimed to examine associations between dietary patterns and musculoskeletal health outcomes in middle-aged women. Diet was measured by the Cancer Council of Victoria FFQ. Total body bone mineral content (TB BMC), femoral neck and lumbar spine bone density (dual-energy X-ray absorptiometry), lower limbs muscle strength (LMS) and balance tests (timed up and go test, step test, functional reach test (FRT) and lateral reach test) were also measured...
October 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28945704/comprehensive-characterization-of-distinct-states-of-human-naive-pluripotency-generated-by-reprogramming
#13
Xiaodong Liu, Christian M Nefzger, Fernando J Rossello, Joseph Chen, Anja S Knaupp, Jaber Firas, Ethan Ford, Jahnvi Pflueger, Jacob M Paynter, Hun S Chy, Carmel M O'Brien, Cheng Huang, Ketan Mishra, Margeaux Hodgson-Garms, Natasha Jansz, Sarah M Williams, Marnie E Blewitt, Susan K Nilsson, Ralf B Schittenhelm, Andrew L Laslett, Ryan Lister, Jose M Polo
Recent reports on the characteristics of naive human pluripotent stem cells (hPSCs) obtained using independent methods differ. Naive hPSCs have been mainly derived by conversion from primed hPSCs or by direct derivation from human embryos rather than by somatic cell reprogramming. To provide an unbiased molecular and functional reference, we derived genetically matched naive hPSCs by direct reprogramming of fibroblasts and by primed-to-naive conversion using different naive conditions (NHSM, RSeT, 5iLAF and t2iLGöY)...
November 2017: Nature Methods
https://www.readbyqxmd.com/read/28935436/associations-between-mri-detected-early-osteophytes-and-knee-structure-in-older-adults-a-population-based-cohort-study
#14
Z Zhu, L L Laslett, W Han, B Antony, F Pan, F Cicuttini, G Jones, C Ding
OBJECTIVES: To describe prevalence of osteophytes (OPs) detected only by magnetic resonance imaging (MRI) but not by standard X-ray in older adults and to evaluate longitudinal associations with knee structural changes. METHODS: 837 participants were randomly selected from the local community and had MRI scans to assess knee OPs and other structures. OPs detected only by MRI but not by standard X-ray were defined as MRI-detected early OPs (MRI-OPs for short). OPs detected by both MRI and X-ray were defined as established-OPs...
September 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28499364/clinical-classification-in-low-back-pain-best-evidence-diagnostic-rules-based-on-systematic-reviews
#15
REVIEW
Tom Petersen, Mark Laslett, Carsten Juhl
BACKGROUND: Clinical examination findings are used in primary care to give an initial diagnosis to patients with low back pain and related leg symptoms. The purpose of this study was to develop best evidence Clinical Diagnostic Rules (CDR] for the identification of the most common patho-anatomical disorders in the lumbar spine; i.e. intervertebral discs, sacroiliac joints, facet joints, bone, muscles, nerve roots, muscles, peripheral nerve tissue, and central nervous system sensitization...
May 12, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28493529/pain-in-knee-osteoarthritis-is-associated-with-variation-in-the-neurokinin-1-substance-p-receptor-tacr1-gene
#16
S C Warner, D A Walsh, L L Laslett, R A Maciewicz, A Soni, D J Hart, W Zhang, K R Muir, E M Dennison, P Leaverton, E Rampersaud, C Cooper, T D Spector, F M Cicuttini, N K Arden, G Jones, M Doherty, A M Valdes
BACKGROUND: Substance P (SP) is a pain- and inflammation-related neuropeptide which preferentially binds to the neurokinin receptor 1 (NK1 ). SP and NK1 receptors have been implicated in joint pain, inflammation and damage in animal models and human studies of osteoarthritis (OA). The aim of this study was to test if genetic variation at the neurokinin 1 receptor gene (TACR1) is associated with pain in individuals with radiographic knee OA. METHODS: Participants from the Genetics of OA and Lifestyle study were used for the discovery group (n = 1615)...
August 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28317499/a-multi-country-study-of-harms-to-children-because-of-others-drinking
#17
Anne-Marie Laslett, Georgia Rankin, Orratai Waleewong, Sarah Callinan, Hanh T M Hoang, Ramon Florenzano, Siri Hettige, Isidore Obot, Latsamy Siengsounthone, Akanidomo Ibanga, Ann Hope, Jonas Landberg, Hanh T M Vu, Thaksaphon Thamarangsi, Dag Rekve, Robin Room
OBJECTIVE: This study aims to ascertain and compare the prevalence and correlates of alcohol-related harms to children cross-nationally. METHOD: National and regional sample surveys of randomly selected households included 7,848 carers (4,223 women) from eight countries (Australia, Chile, Ireland, Lao People's Democratic Republic [PDR], Nigeria, Sri Lanka, Thailand, and Vietnam). Country response rates ranged from 35% to 99%. Face-to-face or telephone surveys asking about harm from others' drinking to children ages 0-17 years were conducted, including four specific harms: that because of others' drinking in the past year children had been (a) physically hurt, (b) verbally abused, (c) exposed to domestic violence, or (d) left unsupervised...
March 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28276085/both-baseline-and-change-in-lower-limb-muscle-strength-in-younger-women-are-independent-predictors-of-balance-in-middle-age-a-12-year-population-based-prospective-study
#18
Feitong Wu, Michele Callisaya, Karen Wills, Laura L Laslett, Graeme Jones, Tania Winzenberg
Poor balance is a risk factor for falls and fracture in older adults, but little is known about modifiable factors affecting balance in younger women. This study aimed to examine whether lower limb muscle strength (LMS) in young women and changes in LMS are independent predictors of balance in middle age. This was an observational 10-year follow-up of 470 women aged 25 to 44 years at baseline who had previously participated in a 2-year population-based randomized controlled trial of osteoporosis education interventions...
June 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28259835/scaffolds-for-3d-in-vitro-culture-of-neural-lineage-cells
#19
REVIEW
Ashley R Murphy, Andrew Laslett, Carmel M O'Brien, Neil R Cameron
Understanding how neurodegenerative disorders develop is not only a key challenge for researchers but also for the wider society, given the rapidly aging populations in developed countries. Advances in this field require new tools with which to recreate neural tissue in vitro and produce realistic disease models. This in turn requires robust and reliable systems for performing 3D in vitro culture of neural lineage cells. This review provides a state of the art update on three-dimensional culture systems for in vitro development of neural tissue, employing a wide range of scaffold types including hydrogels, solid porous polymers, fibrous materials and decellularised tissues as well as microfluidic devices and lab-on-a-chip systems...
March 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28115233/association-between-mri-detected-osteophytes-and-changes-in-knee-structures-and-pain-in-older-adults-a-cohort-study
#20
Z Zhu, L L Laslett, X Jin, W Han, B Antony, X Wang, M Lu, F Cicuttini, G Jones, C Ding
OBJECTIVE: To describe cross-sectional and longitudinal associations between magnetic resonance imaging (MRI)-detected osteophytes (OPs) and knee structural abnormalities and knee pain in older adults. METHOD: A prospective population-based cohort study of 895 participants aged 50-80 years (mean age 62 years, 50% female) was performed. T1-or T2-weighted fat suppressed MRI was used to assess knee OPs, cartilage volume, cartilage defects and bone marrow lesions (BMLs) at baseline and after 2...
January 21, 2017: Osteoarthritis and Cartilage
keyword
keyword
7419
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"