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F Wu, K Wills, L L Laslett, B Oldenburg, M J Seibel, G Jones, T Winzenberg
: This was the first study examining optimal vitamin D status for musculoskeletal health in middle-aged women. A 25-hydroxyvitamin D level of at least 29 to 33 nmol/L appears required for optimal musculoskeletal health, but the current cut-off of 50 nmol/L may be warranted. INTRODUCTION: This study aimed to determine whether cut-points exist for associations between serum 25-hydroxyvitamin D (25OHD) and musculoskeletal health outcomes in middle-aged women, below which greater 25OHD levels are associated with musculoskeletal health benefits and above which no such associations exist...
September 9, 2016: Osteoporosis International
Feng Pan, Laura Laslett, Jing Tian, Flavia Cicuttini, Tania Winzenberg, Changhai Ding, Graeme Jones
OBJECTIVE: Pain is common in the elderly. Knee pain may predict knee cartilage loss, but whether generalised pain is associated with knee cartilage loss is unclear. This study, therefore, aimed to determine whether pain at multiple sites predicts knee cartilage volume loss amongst community-dwelling older adults, and if so, to explore potential mechanisms. METHODS: Data from the prospective Tasmanian Older Adult Cohort study was utilised (n=394; mean age, 63 years; range 52 to 79)...
July 7, 2016: Arthritis Care & Research
Feng Pan, Laura Laslett, Leigh Blizzard, Flavia Cicuttini, Tania Winzenberg, Changhai Ding, Graeme Jones
OBJECTIVE: Pain is common in older adults and typically involves multiple sites. Obesity is an important risk factor in the pathogenesis of pain and multi-site pain (MSP). This study aimed to examine longitudinal associations between fat mass and MSP, and to explore the potential mechanisms of any associations. METHODS: Data from a longitudinal population-based study of older adults (n=1099) was utilized with measurements at baseline and after 2.6 and 5.1 years...
July 7, 2016: Arthritis Care & Research
Zhaohua Zhu, Changhai Ding, Xingzhong Jin, Benny Antony, Weiyu Han, Laura L Laslett, Flavia Cicuttini, Graeme Jones
OBJECTIVE: To describe the natural history of patellofemoral joint (PFJ) bone marrow lesions (BMLs) over 2.6 years and associations between change in PFJ BMLs, knee pain and knee cartilage morphology in older adults over 5 years. METHODS: Prospective population-based cohort study of men and women aged 50-80 years (mean age 63 years, n=406) was performed. PFJ BMLs, knee cartilage volume and cartilage defect scores (0-4) were measured using Whole-Organ Magnetic Resonance Imaging Score (WORMS) system at baseline and 2...
March 4, 2016: Arthritis Care & Research
David Scott, Sahan D Chandrasekara, Laura L Laslett, Flavia Cicuttini, Peter R Ebeling, Graeme Jones
The purpose of this study is to determine whether low muscle mass (sarcopenia) or strength (dynapenia), in the presence of obesity, are associated with increased risk for osteoporosis and non-vertebral fracture over 5-10 years in community-dwelling older adults. N = 1089 volunteers (mean ± SD age 62 ± 7 years; 51 % female) participated at baseline and 761 attended follow-up clinics (mean 5.1 ± 0.5 years later). Total body, total hip and spine BMD, and appendicular lean and total fat mass were assessed by DXA...
July 2016: Calcified Tissue International
F Wu, M Callisaya, L L Laslett, K Wills, Y Zhou, G Jones, T Winzenberg
UNLABELLED: This was the first study investigating both linear associations between lower limb muscle strength and balance in middle-aged women and the potential for thresholds for the associations. There was strong evidence that even in middle-aged women, poorer LMS was associated with reduced balance. However, no evidence was found for thresholds. INTRODUCTION: Decline in balance begins in middle age, yet, the role of muscle strength in balance is rarely examined in this age group...
July 2016: Osteoporosis International
Joanna Hall, Laura L Laslett, Johanne Martel-Pelletier, Jean-Pierre Pelletier, François Abram, Chang-Hai Ding, Flavia M Cicuttini, Graeme Jones
BACKGROUND: Change in knee cartilage volume is frequently used as a proxy for change in knee joint space width over time, but longitudinal data on these associations is limited. We aimed to determine whether change in knee cartilage volume, new or worsening meniscal extrusion (ME), meniscal tears and cartilage defects over 2.4 years correlated with change in joint space width (JSW) over 5 years in older community dwelling adults. METHODS: Participants (n = 153) had their right knee imaged using MR imaging and x-ray at baseline, and after 2...
2016: BMC Musculoskeletal Disorders
Xingzhong Jin, Changhai Ding, Xia Wang, Benny Antony, Laura L Laslett, Leigh Blizzard, Flavia Cicuttini, Graeme Jones
OBJECTIVE: The aim of this study was to describe the longitudinal relationship between adiposity and change in knee pain. METHODS: A total of 1099 participants aged 50-79 were randomly selected from the local community in Southern Tasmania, of which 767 were followed up on average 5.1 years later. Knee pain was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at each time point. Consistent knee pain was defined as knee pain at all three time-points...
April 2016: Seminars in Arthritis and Rheumatism
Lawrence Laslett, H Vernon Anderson, Bernard Clark, Timothy A Dewhurst, Thad F Waites, Sean Wilson, Steve Erickson, Anne Marie Smith
No abstract text is available yet for this article.
November 10, 2015: Journal of the American College of Cardiology
Feitong Wu, Laura L Laslett, Qian Zhang
CONTEXT: There is no consensus on the definition of vitamin D deficiency for bone health based on serum 25-hydroxyvitamin D (25OHD) levels. OBJECTIVE: Our objective was to determine whether thresholds exist for associations between 25OHD levels and bone outcomes and if low 25OHD levels have adverse effects on bone health. DESIGN: This is a cross-sectional study. PARTICIPANTS: This study included secondary school students in Beijing, China, aged 12-15 years...
December 2015: Journal of Clinical Endocrinology and Metabolism
Yu-Chieh Wang, Jason W Stein, Candace L Lynch, Ha T Tran, Chia-Yao Lee, Ronald Coleman, Adam Hatch, Victor G Antontsev, Hun S Chy, Carmel M O'Brien, Shashi K Murthy, Andrew L Laslett, Suzanne E Peterson, Jeanne F Loring
Many studies have suggested the significance of glycosyltransferase-mediated macromolecule glycosylation in the regulation of pluripotent states in human pluripotent stem cells (hPSCs). Here, we observed that the sialyltransferase ST6GAL1 was preferentially expressed in undifferentiated hPSCs compared to non-pluripotent cells. A lectin which preferentially recognizes α-2,6 sialylated galactosides showed strong binding reactivity with undifferentiated hPSCs and their glycoproteins, and did so to a much lesser extent with differentiated cells...
2015: Scientific Reports
Jingyu Cai, Jianhua Xu, Kang Wang, Shuang Zheng, Fan He, Shuting Huan, Shengqing Xu, Hui Zhang, Laura Laslett, Changhai Ding
OBJECTIVE: The function of the infrapatellar fat pad (IPFP) in knee osteoarthritis (OA) remains uncertain. This study aimed to examine cross-sectional associations between IPFP volume and knee structures in patients with knee OA. METHODS: The study included 174 patients with clinical knee OA (mean age, 55.5 yrs). Fat-suppressed 3-D T1-weighted spoiled gradient recall magnetic resonance imaging (MRI) was used to measure the IPFP and cartilage volume. T2-weighted fast spin echo MRI was used to assess cartilage defects and bone marrow lesions (BML)...
October 2015: Journal of Rheumatology
J Abimanyi-Ochom, J J Watts, F Borgström, G C Nicholson, C Shore-Lorenti, A L Stuart, Y Zhang, S Iuliano, E Seeman, R Prince, L March, M Cross, T Winzenberg, L L Laslett, G Duque, P R Ebeling, K M Sanders
UNLABELLED: We investigated change in health-related quality of life due to fracture in Australian adults aged over 50 years. Fractures reduce quality of life with the loss sustained at least over 12 months. At a population level, the loss was equivalent to 65 days in full health per fracture. PURPOSE: We aimed to quantify the change in health-related quality of life (HRQoL) that occurred as a consequence of a fracture using the EQ-5D-3 L questionnaire. METHODS: Adults aged ≥50 years with a low to moderate energy fracture were recruited from eight study centres across Australia...
June 2015: Osteoporosis International
Graeme Jones, Tania M Winzenberg, Michele L Callisaya, Laura L Laslett
This review covers the evidence relating to lifestye modification in the big three musculoskeletal conditions: osteoarthritis, osteoporosis and rheumatoid arthritis. Lifestyle is of considerable importance in the first two and there is emerging evidence for rheumatoid arthritis despite it not traditionally being considered a lifestyle disease.
June 2014: Best Practice & Research. Clinical Rheumatology
Steven G White, Peter McNair, Mark Laslett, Wayne Hing
OBJECTIVE: To determine the reliability of patient reports of pain intensity during the application of physical tests. METHODS: A single examiner required participants to use the numeric pain rating scale (NPRS) to report the intensity of pain provoked during physical testing of the hip. Standardized versions of 14 physical tests were used on 18 people with hip pain. Tests were repeated at 1 hour and 2-7 days later. Within- and between-session reliability of reports of pain intensity was calculated using intraclass correlation coefficients (ICCs) and Lin's concordance correlation coefficients (CCCs)...
May 2015: Arthritis Care & Research
Elizabeth A Mason, Jessica C Mar, Andrew L Laslett, Martin F Pera, John Quackenbush, Ernst Wolvetang, Christine A Wells
Heterogeneity is a hallmark of stem cell populations, in part due to the molecular differences between cells undergoing self-renewal and those poised to differentiate. We examined phenotypic and molecular heterogeneity in pluripotent stem cell populations, using public gene expression data sets. A high degree of concordance was observed between global gene expression variability and the reported heterogeneity of different human pluripotent lines. Network analysis demonstrated that low-variability genes were the most highly connected, suggesting that these are the most stable elements of the gene regulatory network and are under the highest regulatory constraints...
August 12, 2014: Stem Cell Reports
Feitong Wu, Laura L Laslett, Karen Wills, Brian Oldenburg, Graeme Jones, Tania Winzenberg
This is 12-yr follow-up of a randomized controlled trial aimed to evaluate the long-term effects of bone density feedback and osteoporosis education on osteoporosis knowledge and self-efficacy. We examined the effects of feedback of bone density-defined fracture risk (high [T-score <0] vs normal [T-score ≥0] risk) and 2 different educational interventions (the group-based Osteoporosis Prevention and Self-Management Course [OPSMC] vs an osteoporosis leaflet) on osteoporosis knowledge and self-efficacy in women aged 25-44...
October 2014: Journal of Clinical Densitometry
Mark Laslett, Michael Steele, Wayne Hing, Peter McNair, Angela Cadogan
OBJECTIVE: Identify predictor variables and models for clinical outcomes for primary care shoulder pain patients to 12 months follow-up. DESIGN: A non-randomized audit with measures of pain and disability at 3 weeks, 3, 6 and 12 months. PATIENTS: Of 208 patients, 161 agreed to participate with 96.9, 98.1, 87.0 and 83.9% follow-up at 3 weeks, 3, 6 and 12 months respectively. Treatment consisted of exercise and manual therapy-based physiotherapy and corticosteroid injection under specified selection criteria...
January 2015: Journal of Rehabilitation Medicine
Mark Laslett, Michael Steele, Wayne Hing, Peter McNair, Angela Cadogan
OBJECTIVE: Measure changes in pain and disability of primary care shoulder pain patients over a 12-month period. DESIGN: A non-randomized audit with repeated measures of pain and disability at 3 weeks, 3, 6 and 12 months. PATIENTS: Of 208 patients, 161 agreed to participate with 96.9%, 98.1%, 86.3%, 83.9% follow-up at 3 weeks, at 3, 6 and 12 months, respectively. Mean age was 44 years, mean symptom duration 3.6 months. METHODS: PATIENTS were treated with protocol driven corticosteroid injection and community based care...
October 2014: Journal of Rehabilitation Medicine
Heng Jiang, Sarah Callinan, Anne-Marie Laslett, Robin Room
INTRODUCTION AND AIMS: This study identifies the correlates of caring for harmful drinkers and others, and examines how caring for that person impacts on respondents' well-being and use of services. DESIGN AND METHODS: The study utilises the data from the 2008 Australian Alcohol Harm to Others Survey (n = 2649), in which 778 respondents reported they were harmed because of the drinking of someone they knew. Respondents were asked about the person they were most adversely affected by and whether they spent time caring for this person because of their drinking...
March 2015: Drug and Alcohol Review
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