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Joseph Gorman

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https://www.readbyqxmd.com/read/28429161/on-the-in-vivo-function-of-the-mitral-heart-valve-leaflet-insights-into-tissue-interstitial-cell-biomechanical-coupling
#1
Chung-Hao Lee, Will Zhang, Kristen Feaver, Robert C Gorman, Joseph H Gorman, Michael S Sacks
There continues to be a critical need for developing data-informed computational modeling techniques that enable systematic evaluations of mitral valve (MV) function. This is important for a better understanding of MV organ-level biomechanical performance, in vivo functional tissue stresses, and the biosynthetic responses of MV interstitial cells (MVICs) in the normal, pathophysiological, and surgically repaired states. In the present study, we utilized extant ovine MV population-averaged 3D fiducial marker data to quantify the MV anterior leaflet (MVAL) deformations in various kinematic states...
April 20, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28347308/erratum-to-assessment-of-myocardial-injury-after-reperfused-infarction-by-t1%C3%AF-cardiovascular-magnetic-resonance
#2
Rutger H Stoffers, Marie Madden, Mohammed Shahid, Francisco Contijoch, Joseph Solomon, James J Pilla, Joseph H Gorman, Robert C Gorman, Walter R T Witschey
No abstract text is available yet for this article.
March 27, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28274519/regional-heterogeneity-in-the-mitral-valve%C3%A2-apparatus-in-patients-with-ischemic%C3%A2-mitral-regurgitation
#3
Feroze Mahmood, Ziyad O Knio, Lu Yeh, Rabia Amir, Robina Matyal, Azad Mashari, Robert C Gorman, Joseph H Gorman, Kamal R Khabbaz
BACKGROUND: Apical displacement of the coaptation point of the mitral valve (MV) in response to ischemic mitral regurgitation (IMR) represents remodeling of the MV apparatus. Whereas it implies chronicity, it lacks specificity in discriminating normal from a significantly remodeled MV apparatus. Regional aspects of MV remodeling have shown superior value over global remodeling in predicting recurrence after MV repair for IMR. Quite possibly, presence of specific regional changes in MV geometry that are unique to chronic IMR patients could also be used to diagnose the presence and track progression of remodeling...
March 5, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28196494/assessment-of-myocardial-injury-after-reperfused-infarction-by-t1%C3%AF-cardiovascular-magnetic-resonance
#4
Rutger H Stoffers, Marie Madden, Mohammed Shahid, Francisco Contijoch, Joseph Solomon, James J Pilla, Joseph H Gorman, Robert C Gorman, Walter R T Witschey
BACKGROUND: The evolution of T1ρ and of other endogenous contrast methods (T2, T1) in the first month after reperfused myocardial infarction (MI) is uncertain. We conducted a study of reperfused MI in pigs to serially monitor T1ρ, T2 and T1 relaxation, scar size and transmurality at 1 and 4 weeks post-MI. METHODS: Ten Yorkshire swine underwent 90 min of occlusion of the circumflex artery and reperfusion. T1ρ, T2 and native T1 maps and late gadolinium enhanced (LGE) cardiovascular magnetic resonance (CMR) data were collected at 1 week (n = 10) and 4 weeks (n = 5)...
February 15, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28125075/assigning-clinical-meaning-to-somatic-and-germ-line-whole-exome-sequencing-data-in-a-prospective-cancer-precision-medicine-study
#5
Arezou A Ghazani, Nelly M Oliver, Joseph P St Pierre, Andrea Garofalo, Irene R Rainville, Elaine Hiller, Daniel J Treacy, Vanesa Rojas-Rudilla, Sam Wood, Elizabeth Bair, Michael Parello, Franklin Huang, Marios Giannakis, Frederick H Wilson, Elizabeth H Stover, Steven M Corsello, Tom Nguyen, Huma Q Rana, Alanna J Church, Carol Lowenstein, Carrie Cibulskis, Ali Amin-Mansour, Jennifer Heng, Lauren Brais, Abigail Santos, Patrick Bauer, Amanda Waldron, Peter Lo, Megan Gorman, Christine A Lydon, Marisa Welch, Philip McNamara, Stacey Gabriel, Lynette M Sholl, Neal I Lindeman, Judy E Garber, Steven Joffe, Eliezer M Van Allen, Stacy W Gray, Pasi A Ja Nne, Levi A Garraway, Nikhil Wagle
PURPOSE: Implementing cancer precision medicine in the clinic requires assessing the therapeutic relevance of genomic alterations. A main challenge is the systematic interpretation of whole-exome sequencing (WES) data for clinical care. METHODS: One hundred sixty-five adults with metastatic colorectal and lung adenocarcinomas were prospectively enrolled in the CanSeq study. WES was performed on DNA extracted from formalin-fixed paraffin-embedded tumor biopsy samples and matched blood samples...
January 26, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/27995395/mitral-valve-chordae-tendineae-topological-and-geometrical-characterization
#6
Amir H Khalighi, Andrew Drach, Charles H Bloodworth, Eric L Pierce, Ajit P Yoganathan, Robert C Gorman, Joseph H Gorman, Michael S Sacks
Mitral valve (MV) closure depends upon the proper function of each component of the valve apparatus, which includes the annulus, leaflets, and chordae tendineae (CT). Geometry plays a major role in MV mechanics and thus highly impacts the accuracy of computational models simulating MV function and repair. While the physiological geometry of the leaflets and annulus have been previously investigated, little effort has been made to quantitatively and objectively describe CT geometry. The CT constitute a fibrous tendon-like structure projecting from the papillary muscles (PMs) to the leaflets, thereby evenly distributing the loads placed on the MV during closure...
February 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27916240/spatial-phenotyping-of-the-endocardial-endothelium-as-a-function-of-intracardiac-hemodynamic-shear-stress
#7
Margaret E McCormick, Elisabetta Manduchi, Walter R T Witschey, Robert C Gorman, Joseph H Gorman, Yi-Zhou Jiang, Christian J Stoeckert, Alex J Barker, Samuel Yoon, Michael Markl, Peter F Davies
Despite substantial evidence for the central role of hemodynamic shear stress in the functional integrity of vascular endothelial cells, hemodynamic and molecular regulation of the endocardial endothelium lining the heart chambers remains understudied. We propose that regional differences in intracardiac hemodynamics influence differential endocardial gene expression leading to phenotypic heterogeneity of this cell layer. Measurement of intracardiac hemodynamics was performed using 4-dimensional flow MRI in healthy humans (n=8) and pigs (n=5)...
January 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/27783858/heart-valve-biomechanics-and-underlying-mechanobiology
#8
Salma Ayoub, Giovanni Ferrari, Robert C Gorman, Joseph H Gorman, Frederick J Schoen, Michael S Sacks
Heart valves control unidirectional blood flow within the heart during the cardiac cycle. They have a remarkable ability to withstand the demanding mechanical environment of the heart, achieving lifetime durability by processes involving the ongoing remodeling of the extracellular matrix. The focus of this review is on heart valve functional physiology, with insights into the link between disease-induced alterations in valve geometry, tissue stress, and the subsequent cell mechanobiological responses and tissue remodeling...
September 15, 2016: Comprehensive Physiology
https://www.readbyqxmd.com/read/27729419/injectable-shear-thinning-hydrogels-for-minimally-invasive-delivery-to-infarcted-myocardium-to-limit-left-ventricular-remodeling
#9
Christopher B Rodell, Madonna E Lee, Hua Wang, Satoshi Takebayashi, Tetsushi Takayama, Tomonori Kawamura, Jeffrey S Arkles, Neville N Dusaj, Shauna M Dorsey, Walter R T Witschey, James J Pilla, Joseph H Gorman, Jonathan F Wenk, Jason A Burdick, Robert C Gorman
BACKGROUND: Injectable, acellular biomaterials hold promise to limit left ventricular remodeling and heart failure precipitated by infarction through bulking or stiffening the infarct region. A material with tunable properties (eg, mechanics, degradation) that can be delivered percutaneously has not yet been demonstrated. Catheter-deliverable soft hydrogels with in vivo stiffening to enhance therapeutic efficacy achieve these requirements. METHODS AND RESULTS: We developed a hyaluronic acid hydrogel that uses a tandem crosslinking approach, where the first crosslinking (guest-host) enabled injection and localized retention of a soft (<1 kPa) hydrogel...
October 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27662847/implantation-of-the-medtronic-harmony-transcatheter-pulmonary-valve-improves-right-ventricular-size-and-function-in-an-ovine-model-of-postoperative-chronic-pulmonary-insufficiency
#10
Rosanne C Schoonbeek, Satoshi Takebayashi, Chikashi Aoki, Toru Shimaoka, Matthew A Harris, Gregory L Fu, Timothy S Kim, Yoav Dori, Jeremy McGarvey, Harold Litt, Wobbe Bouma, Gerald Zsido, Andrew C Glatz, Jonathan J Rome, Robert C Gorman, Joseph H Gorman, Matthew J Gillespie
BACKGROUND: Pulmonary insufficiency is the nexus of late morbidity and mortality after transannular patch repair of tetralogy of Fallot. This study aimed to establish the feasibility of implantation of the novel Medtronic Harmony transcatheter pulmonary valve (hTPV) and to assess its effect on pulmonary insufficiency and ventricular function in an ovine model of chronic postoperative pulmonary insufficiency. METHODS AND RESULTS: Thirteen sheep underwent baseline cardiac magnetic resonance imaging, surgical pulmonary valvectomy, and transannular patch repair...
October 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27591094/computational-investigation-of-transmural-differences-in-left-ventricular-contractility
#11
Hua Wang, Xiaoyan Zhang, Shauna M Dorsey, Jeremy R McGarvey, Kenneth S Campbell, Jason A Burdick, Joseph H Gorman, James J Pilla, Robert C Gorman, Jonathan F Wenk
Myocardial contractility of the left ventricle (LV) plays an essential role in maintaining normal pump function. A recent ex vivo experimental study showed that cardiomyocyte force generation varies across the three myocardial layers of the LV wall. However, the in vivo distribution of myocardial contractile force is still unclear. The current study was designed to investigate the in vivo transmural distribution of myocardial contractility using a noninvasive computational approach. For this purpose, four cases with different transmural distributions of maximum isometric tension (Tmax) and/or reference sarcomere length (lR) were tested with animal-specific finite element (FE) models, in combination with magnetic resonance imaging (MRI), pressure catheterization, and numerical optimization...
November 1, 2016: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/27579717/self-gated-mri-of-multiple-beat-morphologies-in-the-presence-of-arrhythmias
#12
Francisco Contijoch, Srikant Kamesh Iyer, James J Pilla, Paul Yushkevich, Joseph H Gorman, Robert C Gorman, Harold Litt, Yuchi Han, Walter R T Witschey
PURPOSE: Develop self-gated MRI for distinct heartbeat morphologies in subjects with arrhythmias. METHODS: Golden angle radial data was obtained in seven sinus and eight arrhythmias subjects. An image-based cardiac navigator was derived from single-shot images, distinct beat types were identified, and images were reconstructed for repeated morphologies. Image sharpness, contrast, and volume variation were quantified and compared with self-gated MRI. Images were scored for image quality and artifacts...
August 31, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27530639/the-value-of-preoperative-3-dimensional-over-2-dimensional-valve-analysis-in-predicting-recurrent-ischemic-mitral-regurgitation-after-mitral-annuloplasty
#13
Inez J Wijdh-den Hamer, Wobbe Bouma, Eric K Lai, Melissa M Levack, Eric K Shang, Alison M Pouch, Thomas J Eperjesi, Theodore J Plappert, Paul A Yushkevich, Judy Hung, Massimo A Mariani, Kamal R Khabbaz, Thomas G Gleason, Feroze Mahmood, Michael A Acker, Y Joseph Woo, Albert T Cheung, Matthew J Gillespie, Benjamin M Jackson, Joseph H Gorman, Robert C Gorman
OBJECTIVES: Repair for ischemic mitral regurgitation with undersized annuloplasty is characterized by high recurrence rates. We sought to determine the value of pre-repair 3-dimensional echocardiography over 2-dimensional echocardiography in predicting recurrence at 6 months. METHODS: Intraoperative transesophageal 2-dimensional echocardiography and 3-dimensional echocardiography were performed in 50 patients undergoing undersized annuloplasty for ischemic mitral regurgitation...
September 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27492671/modeling-the-myxomatous-mitral-valve-with-three-dimensional-echocardiography
#14
Alison M Pouch, Benjamin M Jackson, Eric Lai, Manabu Takebe, Sijie Tian, Albert T Cheung, Y Joseph Woo, Prakash A Patel, Hongzhi Wang, Paul A Yushkevich, Robert C Gorman, Joseph H Gorman
BACKGROUND: Degenerative mitral valve disease is associated with variable and complex defects in valve morphology. Three-dimensional echocardiography (3DE) has shown promise in aiding preoperative planning for patients with this disease but to date has not been as transformative as initially predicted. The clinical usefulness of 3DE has been limited by the laborious methods currently required to extract quantitative data from the images. METHODS: To maximize the utility of 3DE for preoperative valve evaluation, this work describes an automated 3DE image analysis method for generating models of the mitral valve that are well suited for both qualitative and quantitative assessment...
September 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27247400/envelope-residue-375-substitutions-in-simian-human-immunodeficiency-viruses-enhance-cd4-binding-and-replication-in-rhesus-macaques
#15
Hui Li, Shuyi Wang, Rui Kong, Wenge Ding, Fang-Hua Lee, Zahra Parker, Eunlim Kim, Gerald H Learn, Paul Hahn, Ben Policicchio, Egidio Brocca-Cofano, Claire Deleage, Xingpei Hao, Gwo-Yu Chuang, Jason Gorman, Matthew Gardner, Mark G Lewis, Theodora Hatziioannou, Sampa Santra, Cristian Apetrei, Ivona Pandrea, S Munir Alam, Hua-Xin Liao, Xiaoying Shen, Georgia D Tomaras, Michael Farzan, Elena Chertova, Brandon F Keele, Jacob D Estes, Jeffrey D Lifson, Robert W Doms, David C Montefiori, Barton F Haynes, Joseph G Sodroski, Peter D Kwong, Beatrice H Hahn, George M Shaw
Most simian-human immunodeficiency viruses (SHIVs) bearing envelope (Env) glycoproteins from primary HIV-1 strains fail to infect rhesus macaques (RMs). We hypothesized that inefficient Env binding to rhesus CD4 (rhCD4) limits virus entry and replication and could be enhanced by substituting naturally occurring simian immunodeficiency virus Env residues at position 375, which resides at a critical location in the CD4-binding pocket and is under strong positive evolutionary pressure across the broad spectrum of primate lentiviruses...
June 14, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27245809/characteristics-of-youth-with-combined-histories-of-violent-behavior-suicidal-ideation-or-behavior-and-gun-carrying
#16
Joseph E Logan, Kevin J Vagi, Deborah Gorman-Smith
BACKGROUND: Youth reporting combined histories of nonfatal violence, suicidal ideation/behavior, and gun-carrying (VSG) are at risk for perpetrating fatal interpersonal violence and self-harm. AIMS: We characterized these youth to inform prevention efforts. METHOD: We analyzed 2004 data from 3,931 seventh-, ninth-, and 11-12th-grade youth and compared VSG youth (n = 66) with non-gun carrying youth who either had no histories of violence or suicidal thoughts/behavior (n = 1,839), histories of violence (n = 884), histories of suicidal thoughts/behaviors (n = 552), or both (n = 590)...
November 2016: Crisis
https://www.readbyqxmd.com/read/27212145/quantitative-evidence-for-the-effects-of-multiple-drivers-on-continental-scale-amphibian-declines
#17
Evan H Campbell Grant, David A W Miller, Benedikt R Schmidt, Michael J Adams, Staci M Amburgey, Thierry Chambert, Sam S Cruickshank, Robert N Fisher, David M Green, Blake R Hossack, Pieter T J Johnson, Maxwell B Joseph, Tracy A G Rittenhouse, Maureen E Ryan, J Hardin Waddle, Susan C Walls, Larissa L Bailey, Gary M Fellers, Thomas A Gorman, Andrew M Ray, David S Pilliod, Steven J Price, Daniel Saenz, Walt Sadinski, Erin Muths
Since amphibian declines were first proposed as a global phenomenon over a quarter century ago, the conservation community has made little progress in halting or reversing these trends. The early search for a "smoking gun" was replaced with the expectation that declines are caused by multiple drivers. While field observations and experiments have identified factors leading to increased local extinction risk, evidence for effects of these drivers is lacking at large spatial scales. Here, we use observations of 389 time-series of 83 species and complexes from 61 study areas across North America to test the effects of 4 of the major hypothesized drivers of declines...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27207385/in-vivo-heterogeneous-functional-and-residual-strains-in-human-aortic-valve-leaflets
#18
Ankush Aggarwal, Alison M Pouch, Eric Lai, John Lesicko, Paul A Yushkevich, Joseph H Gorman Iii, Robert C Gorman, Michael S Sacks
Residual and physiological functional strains in soft tissues are known to play an important role in modulating organ stress distributions. Yet, no known comprehensive information on residual strains exist, or non-invasive techniques to quantify in-vivo deformations for the aortic valve (AV) leaflets. Herein we present a completely non-invasive approach for determining heterogeneous strains - both functional and residual - in semilunar valves and apply it to normal human AV leaflets. Transesophageal 3D echocardiographic (3DE) images of the AV were acquired from open-heart transplant patients, with each AV leaflet excised after heart explant and then imaged in a flattened configuration ex-vivo...
August 16, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27153460/effects-of-using-the-unloaded-configuration-in-predicting-the-in-vivo-diastolic-properties-of-the-heart
#19
Amir Nikou, Shauna M Dorsey, Jeremy R McGarvey, Joseph H Gorman, Jason A Burdick, James J Pilla, Robert C Gorman, Jonathan F Wenk
Computational models are increasingly being used to investigate the mechanical properties of cardiac tissue. While much insight has been gained from these studies, one important limitation associated with computational modeling arises when using in vivo images of the heart to generate the reference state of the model. An unloaded reference configuration is needed to accurately represent the deformation of the heart. However, it is rare for a beating heart to actually reach a zero-pressure state during the cardiac cycle...
December 2016: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/27133454/how-local-annular-force-and-collagen-density-govern-mitral-annuloplasty-ring-dehiscence-risk
#20
Eric L Pierce, Andrew W Siefert, Deborah M Paul, Sarah K Wells, Charles H Bloodworth, Satoshi Takebayashi, Chikashi Aoki, Morten O Jensen, Matthew J Gillespie, Robert C Gorman, Joseph H Gorman, Ajit P Yoganathan
BACKGROUND: Annuloplasty ring dehiscence is a well described mode of mitral valve repair failure. Defining the mechanisms underlying dehiscence may facilitate its prevention. METHODS: Factors that govern suture dehiscence were examined with an ovine model. After undersized ring annuloplasty in live animals (n = 5), cyclic force (FC) that acts on sutures during cardiac contraction was measured with custom transducers. FC was measured at ten suture positions, throughout cardiac cycles with peak left ventricular pressure (LVPmax) of 100, 125, and 150 mm Hg...
August 2016: Annals of Thoracic Surgery
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