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https://www.readbyqxmd.com/read/29691767/prognostic-impact-of-final-kissing-balloon-technique-after-crossover-stenting-for-the-left-main-coronary-artery-from-the-aoi-lmca-registry
#1
Koji Nishida, Mamoru Toyofuku, Takeshi Morimoto, Masanobu Ohya, Yasushi Fuku, Hirooki Higami, Kyohei Yamaji, Hiromi Muranishi, Yuhei Yamaji, Daisuke Furukawa, Tomohisa Tada, Euihong Ko, Kazushige Kadota, Kenji Ando, Hiroki Sakamoto, Takashi Tamura, Kazuya Kawai, Takeshi Kimura
It is still uncertain whether the final kissing balloon technique (FKBT) is mandatory after crossover stenting for the left main coronary artery (LMCA). Assessing Optimal Percutaneous Coronary Intervention for LMCA (AOI-LMCA) registry, a 6-center retrospective registry, enrolled 1809 consecutive patients for LMCA stenting in Japan. In the present analysis, 5-year clinical outcomes were compared between non-FKBT (n = 160) and FKBT (n = 578) groups in patients treated with crossover stenting with drug-eluting stents from the LMCA to the left anterior descending artery...
April 24, 2018: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/29686230/nomogram-based-prediction-of-rebleeding-in-small-bowel-bleeding-patients-the-prsbb-score
#2
Genta Uchida, Yoshiki Hirooka, Masanao Nakamura, Osamu Watanabe, Takeshi Yamamura, Masanobu Matsushita, Hiroki Suhara, Takuya Ishikawa, Kazuhiro Furukawa, Kohei Funasaka, Eizaburo Ohno, Hiroki Kawashima, Ryoji Miyahara, Hidemi Goto
Small bowel capsule endoscopy (SBCE) and balloon-assisted endoscopy (BAE) have revolutionized the diagnosis and treatment of small bowel bleeding (SBB), allowing access to the small bowel and identification of specific bleeding lesions. However, some patients experience rebleeding after small bowel investigation, and there are no definitive algorithms for determining the most appropriate follow-up strategy in SBB patients. We developed and validated a nomogram that can predict rebleeding risk and be used to develop a risk-stratified follow-up strategy in SBB patients...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29685128/distributional-patterns-of-item-responses-and-total-scores-on-the-phq-9-in-the-general-population-data-from-the-national-health-and-nutrition-examination-survey
#3
Shinichiro Tomitaka, Yohei Kawasaki, Kazuki Ide, Maiko Akutagawa, Hiroshi Yamada, Yutaka Ono, Toshiaki A Furukawa
BACKGROUND: Recently, item responses and total scores on depression screening scales have been reported to have characteristic distributions in the general population. The distributional pattern of responses to the Patient Health Questionnaire-9 (PHQ-9) in the general population has not been well studied. Thus, we carried out a pattern analysis of the PHQ-9 item responses and total scores in US adults. METHODS: Data (5372 individuals) were drawn from the 2013-2014 National Health and Nutrition Examination Survey in the United States...
April 23, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29683968/functional-correlation-between-the-pancreas-and-the-small-intestine-in-humans-the-first-evaluation-using-a-newly-developed-enteroscopy
#4
Daijuro Hayashi, Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Takamichi Kuwahara, Manabu Kawai, Takeshi Yamamura, Kazuhiro Furukawa, Kohei Funasaka, Masanao Nakamura, Ryoji Miyahara, Osamu Watanabe, Masatoshi Ishigami, Senju Hashimoto, Hidemi Goto
OBJECTIVES: The aim of this study is to evaluate a functional correlation between the pancreas and the small intestine and the association of this relationship with nutritional status, using magnifying enteroscopy. METHODS: The subjects were adults aged 20 years or older who underwent upper gastrointestinal endoscopy. An endoscope was inserted into the jejunum, and 10% glucose was sprayed under magnifying observation to evaluate changes in blood flow in the villous capillary network...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29681826/frontal-phonological-agraphia-and-acalculia-with-impaired-verbal-short-term-memory-due-to-left-inferior-precentral-gyrus-lesion
#5
Yasuhisa Sakurai, Emi Furukawa, Masanori Kurihara, Izumi Sugimoto
We report a patient with phonological agraphia (selective impairment of kana [Japanese phonetic writing] nonwords) and acalculia (mental arithmetic difficulties) with impaired verbal short-term memory after a cerebral hemorrhage in the opercular part of the left precentral gyrus (Brodmann area 6) and the adjacent postcentral gyrus. The patient showed phonemic paragraphia in five-character kana nonword writing, minimal acalculia, and reduced digit and letter span. Mental arithmetic normalized after 8 months and agraphia recovered to the normal range at 1 year after onset, in parallel with an improvement of the auditory letter span score from 4 to 6 over a period of 14 months and in the digit span score from 6 to 7 over 24 months...
January 2018: Case Reports in Neurology
https://www.readbyqxmd.com/read/29664906/cigarette-smoking-is-a-risk-factor-for-the-onset-of-fatty-liver-disease-in-nondrinkers-a-longitudinal-cohort-study
#6
Masashi Okamoto, Teruki Miyake, Kohichiro Kitai, Shinya Furukawa, Shin Yamamoto, Hidenori Senba, Sayaka Kanzaki, Akiko Deguchi, Mitsuhito Koizumi, Toru Ishihara, Hiroaki Miyaoka, Osamu Yoshida, Masashi Hirooka, Teru Kumagi, Masanori Abe, Bunzo Matsuura, Yoichi Hiasa
BACKGROUND: The effect of cigarette smoking on the onset of nonalcoholic fatty liver disease (NAFLD) is unclear, especially that associated with drinking small amounts of alcohol. We conducted a longitudinal study to investigate the relationship between cigarette smoking and NAFLD onset, which was stratified according to the amount of alcohol consumed. METHODS: We enrolled 7,905 Japanese subjects who had received annual health checkups more than twice between April 2003 and August 2013, 4,045 of whom met at least one of the following exclusion criteria and were excluded: (a) fatty liver at baseline; (b) hepatitis B or hepatitis C; (c) alcohol consumption (men: ≥210 g/wk; women: ≥140 g/wk); (d) change in alcohol drinking status between baseline and the study's endpoint; (e) change in cigarette smoking habits between baseline and the study's endpoint; or (f) current treatment with antidiabetic agents, antihypertensive agents, and/or lipid-lowering agents...
2018: PloS One
https://www.readbyqxmd.com/read/29662239/elimination-of-tdp-43-inclusions-linked-to-amyotrophic-lateral-sclerosis-by-a-misfolding-specific-intrabody-with-dual-proteolytic-signals
#7
Yoshitaka Tamaki, Akemi Shodai, Toshifumi Morimura, Ryota Hikiami, Sumio Minamiyama, Takashi Ayaki, Ikuo Tooyama, Yoshiaki Furukawa, Ryosuke Takahashi, Makoto Urushitani
Aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) is implicated in the pathogenesis of sporadic and certain familial forms of amyotrophic lateral sclerosis (ALS), suggesting elimination of TDP-43 aggregates as a possible therapeutic strategy. Here we generated and investigated a single-chain variable fragment (scFv) derived from the 3B12A monoclonal antibody (MAb) that recognises D247 of the TDP-43 nuclear export signal, an epitope masked in the physiological state. In transfected HEK293A cells, 3B12A scFv recapitulated the affinity of the full-length MAb to mislocalised TDP-43 with a defective nuclear localising signal and to a TDP-43 inclusion mimic with cysteine-to-serine substitution at RRM1...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29656875/structural-mechanism-of-functional-modulation-by-gene-splicing-in-nmda-receptors
#8
Michael C Regan, Timothy Grant, Miranda J McDaniel, Erkan Karakas, Jing Zhang, Stephen F Traynelis, Nikolaus Grigorieff, Hiro Furukawa
Alternative gene splicing gives rise to N-methyl-D-aspartate (NMDA) receptor ion channels with defined functional properties and unique contributions to calcium signaling in a given chemical environment in the mammalian brain. Splice variants possessing the exon-5-encoded motif at the amino-terminal domain (ATD) of the GluN1 subunit are known to display robustly altered deactivation rates and pH sensitivity, but the underlying mechanism for this functional modification is largely unknown. Here, we show through cryoelectron microscopy (cryo-EM) that the presence of the exon 5 motif in GluN1 alters the local architecture of heterotetrameric GluN1-GluN2 NMDA receptors and creates contacts with the ligand-binding domains (LBDs) of the GluN1 and GluN2 subunits, which are absent in NMDA receptors lacking the exon 5 motif...
April 10, 2018: Neuron
https://www.readbyqxmd.com/read/29653020/developmental-toxicity-of-flucytosine-following-administration-to-pregnant-rats-at-a-specific-time-point-of-organogenesis
#9
Sakiko Fujii, Kaoru Yabe, Yuki Kariwano-Kimura, Masatoshi Furukawa, Kouta Itoh, Masao Matsuura, Masao Horimoto
To investigate the abnormalities that are specific to administration of flucytosine at one time point during embryonic organogenesis, flucytosine was administered orally to pregnant SD rats in a single dose on day 11 of pregnancy at 25 or 35 mg/kg. Fetuses on day 20 of pregnancy were externally, viscerally and skeletally examined. Maternal body weight gain and food consumption were suppressed the day after administration of a 35 mg/kg. Fetal examinations revealed various alterations in both dose groups: externally preaxial polydactyly in the hind limb; skeletally fused lumbar centrum, absent sacral centrum, supernumerary sacral vertebra, and absent ribs...
April 13, 2018: Congenital Anomalies
https://www.readbyqxmd.com/read/29650862/-caregivers-working-in-a-nursing-home-facility-utilizing-a-simulation-program-as-an-effective-preventative-measure-for-pressure-ulcers
#10
Chie Furukawa
The purpose of this study was to clarify if a simulation program utilized by caregivers working in a nursing home is an effective preventative measure for pressure ulcers. The study sample consists of 35caregivers working in a nursing home in Osaka, Japan. The results show that knowledge and practice of preventive measures were significantly higher after using the simulation program for preventive care of pressure ulcers. Nurses and care workers need to cooperate with each other to improve quality of care.
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29629905/presurgical-pazopanib-for-renal-cell-carcinoma-with-inferior-vena-caval-thrombus-a-single-institution-study
#11
Tomoaki Terakawa, Ahmed A Hussein, Yukari Bando, Khurshid A Guru, Junya Furukawa, Katsumi Shigemura, Kenichi Harada, Nobuyuki Hinata, Yuzou Nakano, Masato Fujisawa
The aim of this study was to investigate the clinical benefit of presurgical therapy with pazopanib in renal cell carcinoma (RCC) patients with a tumor thrombus extending to a high level in the vena cava. A retrospective review was performed for seven consecutive patients with RCC and tumor thrombus involving the vena cava above the hepatic vein (level 3-4, Mayo Clinic classification) treated with pazopanib without initial cytoreductive nephrectomy at our institution. The effect of pazopanib was assessed in terms of the primary site response, thrombus diameter, and height (before and after treatment) on computed tomography or MRI...
April 6, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29628364/antidepressants-might-work-for-people-with-major-depression-where-do-we-go-from-here
#12
Andrea Cipriani, Georgia Salanti, Toshi A Furukawa, Matthias Egger, Stefan Leucht, Henricus G Ruhe, Erick H Turner, Lauren Z Atkinson, Anna Chaimani, Julian P T Higgins, Yusuke Ogawa, Nozomi Takeshima, Yu Hayasaka, Hissei Imai, Kiyomi Shinohara, Aran Tajika, John P A Ioannidis, John R Geddes
No abstract text is available yet for this article.
April 5, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29627596/omega-3-fatty-acids-for-a-better-mental-state-in-working-populations-happy-nurse-project-a-52-week-randomized-controlled-trial
#13
Norio Watanabe, Yutaka Matsuoka, Mie Kumachi, Kei Hamazaki, Masaru Horikoshi, Toshi A Furukawa
The efficacy of omega-3 fatty acids for maintaining a better mental state has not been examined among working populations. We aimed to explore the effectiveness of omega-3 fatty acids for hospital nurses. In a multi-center randomized trial, 80 junior nurses were randomly allocated to either omega-3 fatty acids (1200 mg/day of eicosapentaenoic acid and 600 mg/day of docosahexaenoic acid) or identical placebo pills for 13 weeks. The primary outcome was the total score of the Hospital Anxiety and Depression Scale (HADS), determined by a blinded rater at week 26 from the study enrolment...
April 3, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29624381/disodium-benzodipyrrole-sulfonate-as-neutral-hole-transporting-materials-for-perovskite-solar-cells
#14
Rui Shang, Zhongmin Zhou, Hiroki Nishioka, Henry Halim, Shunsuke Furukawa, Izuru Takei, Naoya Ninomiya, Eiichi Nakamura
Hole-transporting material (HTM) is an indispensable constituent in organic electronic devices, generally comprising a donor/dopant combination. We report that a disodium salt of substituted benzo[1,2- b:4,5- b']dipyrrole bearing two racemic alkanediylsulfonate anion side chains (BDPSOs) serves as a neutral, nonhygroscopic, dopant-free HTM for lead perovskite (MAPbI3 ) solar cells. These organic/inorganic hybrid molecules are useful for tunable orbital level and controllable solubility. A fluorinated BDPSO has an energy level matched with MAPbI3 , affording an inverted-structure solar cell that performs with 17...
April 6, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29621987/distribution-of-ossified-spinal-lesions-in-patients-with-severe-ossification-of-the-posterior-longitudinal-ligament-and-prediction-of-ossification-at-each-segment-based-on-the-cervical-op-index-classification-a-multicenter-study-josl-ct-study
#15
Takashi Hirai, Toshitaka Yoshii, Narihito Nagoshi, Kazuhiro Takeuchi, Kanji Mori, Shuta Ushio, Akio Iwanami, Tsuyoshi Yamada, Shoji Seki, Takashi Tsuji, Kanehiro Fujiyoshi, Mitsuru Furukawa, Soraya Nishimura, Kanichiro Wada, Takeo Furuya, Yukihiro Matsuyama, Tomohiko Hasegawa, Katsushi Takeshita, Atsushi Kimura, Masahiko Abematsu, Hirotaka Haro, Tetsuro Ohba, Masahiko Watanabe, Hiroyuki Katoh, Kei Watanabe, Hiroshi Ozawa, Haruo Kanno, Shiro Imagama, Kei Ando, Shunsuke Fujibayashi, Masao Koda, Masashi Yamazaki, Morio Matsumoto, Masaya Nakamura, Atsushi Okawa, Yoshiharu Kawaguchi
BACKGROUND: In patients with ossification of the posterior longitudinal ligament (OPLL) in the cervical spine, it is well known that the thoracic ossified lesions often coexist with the cervical lesions and can cause severe myelopathy. However, the prevalence of OPLL at each level of the thoracic and lumbar spinal segments is unknown. The aims of this study were to investigate how often OPLL occurs at each level in the thoracolumbar spine in patients with a radiological diagnosis of cervical OPLL and to identify the spinal levels most likely to develop ossification...
April 5, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29620793/antidepressants-versus-placebo-for-panic-disorder-in-adults
#16
REVIEW
Irene Bighelli, Mariasole Castellazzi, Andrea Cipriani, Francesca Girlanda, Giuseppe Guaiana, Markus Koesters, Giulia Turrini, Toshi A Furukawa, Corrado Barbui
BACKGROUND: Panic disorder is characterised by repeated, unexpected panic attacks, which represent a discrete period of fear or anxiety that has a rapid onset, reaches a peak within 10 minutes, and in which at least four of 13 characteristic symptoms are experienced, including racing heart, chest pain, sweating, shaking, dizziness, flushing, stomach churning, faintness and breathlessness. It is common in the general population with a lifetime prevalence of 1% to 4%. The treatment of panic disorder includes psychological and pharmacological interventions...
April 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29619778/daikenchuto-for-reducing-postoperative-ileus-in-patients-undergoing-elective-abdominal-surgery
#17
REVIEW
Nobuaki Hoshino, Toshihiko Takada, Koya Hida, Suguru Hasegawa, Toshi A Furukawa, Yoshiharu Sakai
BACKGROUND: Postoperative ileus is a major complication for persons undergoing abdominal surgery. Daikenchuto, a Japanese traditional medicine (Kampo), is a drug that may reduce postoperative ileus. OBJECTIVES: To assess the efficacy and safety of Daikenchuto for reducing prolonged postoperative ileus in persons undergoing elective abdominal surgery. SEARCH METHODS: We searched the following databases on 3 July 2017: CENTRAL, MEDLINE, Embase, ICHUSHI, WHO (World Health Organization) International Clinical Trials Registry Platform (ICTRP), EU Crinical Trials registry (EU-CTR), UMIN Clinical Trials Registry (UMIN-CTR), ClinicalTrials...
April 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29619235/imethyl-an-integrative-database-of-human-dna-methylation-gene-expression-and-genomic-variation
#18
Shohei Komaki, Yuh Shiwa, Ryohei Furukawa, Tsuyoshi Hachiya, Hideki Ohmomo, Ryo Otomo, Mamoru Satoh, Jiro Hitomi, Kenji Sobue, Makoto Sasaki, Atsushi Shimizu
We launched an integrative multi-omics database, iMETHYL (http://imethyl.iwate-megabank.org). iMETHYL provides whole-DNA methylation (~24 million autosomal CpG sites), whole-genome (~9 million single-nucleotide variants), and whole-transcriptome (>14 000 genes) data for CD4+ T-lymphocytes, monocytes, and neutrophils collected from approximately 100 subjects. These data were obtained from whole-genome bisulfite sequencing, whole-genome sequencing, and whole-transcriptome sequencing, making iMETHYL a comprehensive database...
2018: Human Genome Variation
https://www.readbyqxmd.com/read/29618669/identification-of-two-phenanthrene-derivatives-from-australasian-allied-species-in-genus-dendrobium
#19
Tomoko Takamiya, Saki Kitamura, Shunichiro Suzuki, Nao Shioda, Yoshifumi Matsuo, Kento Murase, Yuka Kaiho, Yurika Tsurumaki, Yukiko Fujiwara, Mayumi Sone, Tomomi Machida, Ryohei Matsumoto, Aoi Miyamoto, Dai Hirose, Megumi Furukawa, Mitsuko Makino, Keiichi Matsuzaki, Susumu Kitanaka, Tomohisa Yukawa, Hiroshi Iijima
Genus Dendrobium (Orchidaceae) contains numerous species. Phylogenetic analyses based on morphological characteristics and DNA sequences indicated that this genus is divided into two major groups: Asian and Australasian clades. On the other hand, little is known about the phytochemical differences and similarities among the species in each clade. In this study, we selected 18 Dendrobium species (11 from the Asian clade and 7 from the Australasian clade) and constructed HPLC profiles, arrays composed of relative intensity of the chromatographic peaks...
April 5, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29618282/neuroprotective-effect-of-citrus-kawachiensis-kawachi-bankan-peels-a-rich-source-of-naringin-against-global-cerebral-ischemia-reperfusion-injury-in-mice
#20
Satoshi Okuyama, Kana Yamamoto, Hirotomo Mori, Atsushi Sawamoto, Yoshiaki Amakura, Morio Yoshimura, Arisa Tamanaha, Yuu Ohkubo, Kuniaki Sugawara, Masahiko Sudo, Mitsunari Nakajima, Yoshiko Furukawa
Cerebral ischemia/reperfusion is known to induce the generation of reactive oxygen species and inflammatory responses. Numerous studies have demonstrated that naringin (NGIN) has anti-oxidant and anti-inflammatory properties. We previously reported that Citrus kawachiensis contains a large quantity of NGIN in its peel. In the present study, we orally (p.o.) administered dried peel powder of C. kawachiensis to mice of a transient global ischemia model and found in the hippocampus region that it 1) suppressed neuronal cell death, 2) reversed the reduction in the level of phosphorylated calcium-calmodulin-dependent protein kinase II, 3) had the tendency to reverse the reduction in the level of glutathione, and 4) blocked excessive activation of microglia and astrocytes...
April 4, 2018: Bioscience, Biotechnology, and Biochemistry
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