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https://www.readbyqxmd.com/read/28339642/meaningful-use-of-health-information-technology-and-declines-in-in-hospital-adverse-drug-events
#1
Michael F Furukawa, William D Spector, M Rhona Limcangco, William E Encinosa
Objective: Nationwide initiatives have promoted greater adoption of health information technology as a means to reduce adverse drug events (ADEs). Hospital adoption of electronic health records with Meaningful Use (MU) capabilities expected to improve medication safety has grown rapidly. However, evidence that MU capabilities are associated with declines in in-hospital ADEs is lacking. Methods: Data came from the 2010-2013 Medicare Patient Safety Monitoring System and the 2008-2013 Healthcare Information and Management Systems Society (HIMSS) Analytics Database...
February 16, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28336104/serum-25-hydroxyvitamin-d-and-metabolic-syndrome-in-a-japanese-working-population-the-furukawa-nutrition-and-health-study
#2
Shamima Akter, Masafumi Eguchi, Kayo Kurotani, Takeshi Kochi, Ikuko Kashino, Rie Ito, Keisuke Kuwahara, Hiroko Tsuruoka, Isamu Kabe, Tetsuya Mizoue
OBJECTIVE: Increasing evidence has suggested a protective role of vitamin D on metabolic syndrome (MetS). However, studies addressing this issue are limited in Asia and it remains unclear whether calcium could modify the association. We examined the association of serum 25-hydroxyvitamin D (25(OH)D) status with MetS, and the potential effect modification by calcium intake in a Japanese working population. METHODS: Study subjects were 1790 workers, ages 18 to 69 y, who participated in a health survey at the time of periodic checkup...
April 2017: Nutrition
https://www.readbyqxmd.com/read/28335291/multispectral-emissions-of-lanthanide-doped-gadolinium-oxide-nanophosphors-for-cathodoluminescence-and-near-infrared-upconversion-downconversion-imaging
#3
Doan Thi Kim Dung, Shoichiro Fukushima, Taichi Furukawa, Hirohiko Niioka, Takumi Sannomiya, Kaori Kobayashi, Hiroshi Yukawa, Yoshinobu Baba, Mamoru Hashimoto, Jun Miyake
Comprehensive imaging of a biological individual can be achieved by utilizing the variation in spatial resolution, the scale of cathodoluminescence (CL), and near-infrared (NIR), as favored by imaging probe Gd₂O₃ co-doped lanthanide nanophosphors (NPPs). A series of Gd₂O₃:Ln(3+)/Yb(3+) (Ln(3+): Tm(3+), Ho(3+), Er(3+)) NPPs with multispectral emission are prepared by the sol-gel method. The NPPs show a wide range of emissions spanning from the visible to the NIR region under 980 nm excitation. The dependence of the upconverting (UC)/downconverting (DC) emission intensity on the dopant ratio is investigated...
September 6, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28331373/decrease-of-the-foveal-avascular-zone-area-after-internal-limiting-membrane-peeling-single-case-study
#4
Kazuyuki Kumagai, Akinori Uemura, Mariko Furukawa, Tetsuyuki Suetsugu, Nobuchika Ogino
PURPOSE: To report a patient whose foveal avascular zone (FAZ) decreased after vitrectomy with internal limiting membrane (ILM) peeling. METHODS: A 58-year-old woman underwent successful phacovitrectomy with ILM peeling for a thin epiretinal membrane in an eye with a normal foveal contour. Optical coherence tomography angiographic en face images of the 3 mm×3 mm superficial and deep inner retinal vascular plexuses were examined preoperatively, and on days 1, 2, 9, and 37 postoperatively...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28328709/the-clinical-and-histological-effect-of-a-low-fluence-q-switched-1-064-nm-neodymium-yttrium-aluminum-garnet-laser-for-the-treatment-of-melasma-and-solar-lentigo-in-asians-prospective-randomized-and-split-face-comparative-study
#5
Chikako Kaminaka, Fukumi Furukawa, Yuki Yamamoto
BACKGROUND: The low-fluence Q-switched 1,064-nm neodymium:yttrium-aluminum-garnet laser (QSNYL) is popular for melasma treatment among Asians. OBJECTIVE: This study was to evaluate the clinical and histological effects of the low-fluence QSNYL for treatment of melasma and solar lentigo. MATERIALS AND METHODS: In this randomized split-face clinical study, 22 patients with melasma or solar lentigo received low-fluence QSNYL weekly for 10 sessions on one cheek...
March 21, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28327357/the-ternary-complex-structure-of-d-mandelate-dehydrogenase-with-nadh-and-anilino-oxo-acetate
#6
Nayuta Furukawa, Akimasa Miyanaga, Masahiro Nakajima, Hayao Taguchi
Enterococcus faecium NAD-dependent d-mandelate dehydrogenase (D-ManDH) belongs to a ketopantoate reductase (KPR)-related D-2-hydroxyacid dehydrogenase family, and exhibits broad substrate specificity toward bulky hydrophobic 2-ketoacids, preferring C3-branched substrates. The ternary complex structure of D-ManDH with NADH and anilino(oxo)acetate (AOA) revealed that the substrate binding induces a shear motion of the N-terminal domain along the C-terminal domain, following the hinge motion induced by the NADH binding, and allows the bound NADH molecule to form favorable interactions with a 2-ketoacid substrate...
March 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28326934/activations-of-muscarinic-m1-receptors-in-the-anterior-cingulate-cortex-contribute-to-the-antinociceptive-effect-via-gabaergic-transmission
#7
Kohei Koga, Yu Matsuzaki, Kenji Honda, Fumihiro Eto, Tomonori Furukawa, Keisuke Migita, Keiichi Irie, Kenichi Mishima, Shinya Ueno
Background Cholinergic systems regulate the synaptic transmission resulting in the contribution of the nociceptive behaviors. Anterior cingulate cortex is a key cortical area to play roles in nociception and chronic pain. However, the effect of the activation of cholinergic system for nociception is still unknown in the cortical area. Here, we tested whether the activation of cholinergic receptors can regulate nociceptive behaviors in adult rat anterior cingulate cortex by integrative methods including behavior, immunohistochemical, and electrophysiological methods...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28324487/mitophagy-in-yeast-a-screen-of-mitophagy-deficient-mutants
#8
Kentaro Furukawa, Tomotake Kanki
Mitochondrial autophagy (mitophagy) is a process that selectively degrades mitochondria via autophagy. Recent studies have shown that mitophagy plays an important role in mitochondrial homeostasis by degrading damaged or excess mitochondria. The budding yeast Saccharomyces cerevisiae is a powerful model organism that has been employed to study several biological phenomena. Recently, there has been significant progress in the understanding of mitophagy in yeast following the identification of Atg32, a mitochondrial outer membrane receptor protein for mitophagy...
March 22, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28323019/comparison-of-perceptual-properties-of-auditory-streaming-between-spectral-and-amplitude-modulation-domains
#9
Shimpei Yamagishi, Sho Otsuka, Shigeto Furukawa, Makio Kashino
The two-tone sequence (ABA_), which comprises two different sounds (A and B) and a silent gap, has been used to investigate how the auditory system organizes sequential sounds depending on various stimulus conditions or brain states. Auditory streaming can be evoked by differences not only in the tone frequency ("spectral cue": ΔFTONE, TONE condition) but also in the amplitude modulation rate ("AM cue": ΔFAM, AM condition). The aim of the present study was to explore the relationship between the perceptual properties of auditory streaming for the TONE and AM conditions...
March 17, 2017: Hearing Research
https://www.readbyqxmd.com/read/28319430/finegoldia-magna-myometritis-with-uterine-necrosis-after-uterine-artery-embolisation
#10
Kei Tanaka, Yuma Muraoka, Yumi Toda, Chikage Kiyomoto, Yasuhiro Okubo, Takashi Nagashima, Seishi Furukawa, Masachika Fujiwara, Makoto Mochizuki, Yoichi Kobayashi, Mitsutoshi Iwashita
No abstract text is available yet for this article.
March 20, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28314753/transethnic-meta-analysis-identifies-gsdma-and-prdm1-as-susceptibility-genes-to-systemic-sclerosis
#11
Chikashi Terao, Takahisa Kawaguchi, Philippe Dieude, John Varga, Masataka Kuwana, Marie Hudson, Yasushi Kawaguchi, Marco Matucci-Cerinic, Koichiro Ohmura, Gabriela Riemekasten, Aya Kawasaki, Paolo Airo, Tetsuya Horita, Akira Oka, Eric Hachulla, Hajime Yoshifuji, Paola Caramaschi, Nicolas Hunzelmann, Murray Baron, Tatsuya Atsumi, Paul Hassoun, Takeshi Torii, Meiko Takahashi, Yasuharu Tabara, Masakazu Shimizu, Akiko Tochimoto, Naho Ayuzawa, Hidetoshi Yanagida, Hiroshi Furukawa, Shigeto Tohma, Minoru Hasegawa, Manabu Fujimoto, Osamu Ishikawa, Toshiyuki Yamamoto, Daisuke Goto, Yoshihide Asano, Masatoshi Jinnin, Hirahito Endo, Hiroki Takahashi, Kazuhiko Takehara, Shinichi Sato, Hironobu Ihn, Soumya Raychaudhuri, Katherine Liao, Peter Gregersen, Naoyuki Tsuchiya, Valeria Riccieri, Inga Melchers, Gabriele Valentini, Anne Cauvet, Maria Martinez, Tsuneyo Mimori, Fumihiko Matsuda, Yannick Allanore
OBJECTIVES: Systemic sclerosis (SSc) is an autoimmune disease characterised by skin and systemic fibrosis culminating in organ damage. Previous genetic studies including genome-wide association studies (GWAS) have identified 12 susceptibility loci satisfying genome-wide significance. Transethnic meta-analyses have successfully expanded the list of susceptibility genes and deepened biological insights for other autoimmune diseases. METHODS: We performed transethnic meta-analysis of GWAS in the Japanese and European populations, followed by a two-staged replication study comprising a total of 4436 cases and 14 751 controls...
March 17, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28295603/rapid-abo-genotyping-by-high-speed-droplet-allele-specific-pcr-using-crude-samples
#12
Chiaki Taira, Kazuyuki Matsuda, Naoya Takeichi, Satomi Furukawa, Mitsutoshi Sugano, Takeshi Uehara, Nobuo Okumura, Takayuki Honda
BACKGROUND: ABO genotyping has common tools for personal identification of forensic and transplantation field. We developed a new method based on a droplet allele-specific PCR (droplet-AS-PCR) that enabled rapid PCR amplification. We attempted rapid ABO genotyping using crude DNA isolated from dried blood and buccal cells. METHODS: We designed allele-specific primers for three SNPs (at nucleotides 261, 526, and 803) in exons 6 and 7 of the ABO gene. We pretreated dried blood and buccal cells with proteinase K, and obtained crude DNAs without DNA purification...
March 13, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28295516/twelve-week-multicenter-placebo-controlled-randomized-double-blind-parallel-group-comparative-phase-ii-iii-study-of-benzoyl-peroxide-gel-in-patients-with-acne-vulgaris-a-secondary-publication
#13
Makoto Kawashima, Shinichi Sato, Fukumi Furukawa, Kayoko Matsunaga, Hirohiko Akamatsu, Atsuyuki Igarashi, Yuichiro Tsunemi, Nobukazu Hayashi, Yuki Yamamoto, Toshitaka Nagare, Tsuneo Katsuramaki
A placebo-controlled, randomized, double-blind, parallel-group, comparative, multicenter study was conducted to investigate the efficacy and safety of benzoyl peroxide (BPO) gel, administrated once daily for 12 weeks to Japanese patients with acne vulgaris. Efficacy was evaluated by counting all inflammatory and non-inflammatory lesions. Safety was evaluated based on adverse events, local skin tolerability scores and laboratory test values. All 609 subjects were randomly assigned to receive the study products (2...
March 11, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28291159/67cu-radiolabeling-of-a-multimeric-rgd-peptide-for-%C3%AE-v%C3%AE-3-integrin-targeted-radionuclide-therapy-stability-therapeutic-efficacy-and-safety-studies-in-mice
#14
Zhao-Hui Jin, Takako Furukawa, Tomoyuki Ohya, Mélissa Degardin, Aya Sugyo, Atsushi B Tsuji, Yasuhisa Fujibayashi, Ming-Rong Zhang, Tatsuya Higashi, Didier Boturyn, Pascal Dumy, Tsuneo Saga
OBJECTIVE: Copper-67 (Cu) is one of the most promising radionuclides for internal radiation therapy. Globally, several projects have recently been initiated for developing innovative approaches for the large-scale production of Cu. Encouraged by these, we performed Cu-radiolabeling of a tetrameric cyclic Arg-Gly-Asp (cRGD) peptide conjugate, cyclam-RAFT-c(-RGDfK-)4, which selectively targets αVβ3 integrin (αVβ3), the transmembrane receptor involved in tumor invasion, angiogenesis, and metastasis...
April 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28290167/simple-interrupted-suturing-for-redo-mitral-valve-replacement
#15
Hiroshi Furukawa, Taishi Tamura, Takeshi Honda, Hiroki Takiuchi, Masahiko Kuinose, Kazuo Tanemoto
BACKGROUND: An evaluation was made of the early clinical outcomes and efficacies of simple interrupted suturing (SIS) for redo mitral valve replacement (MVR). METHODS: Among 336 mitral valve surgery patients at the authors' institution between April 2000 and May 2014, a total of 21 redo MVR using SIS (12 women, nine men; mean age 67±11 years; range 32-80 years) participated in the study. Surgical indications for redo MVR were paravalvular leakage (PVL) in 10 patients, prosthetic valve endocarditis in five, mechanical valve thrombosis in three, and structural valve deterioration (SVD) of the bioprosthesis in three...
November 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28289560/pattern-analysis-of-total-item-score-and-item-response-of-the-kessler-screening-scale-for-psychological-distress-k6-in-a-nationally-representative-sample-of-us-adults
#16
Shinichiro Tomitaka, Yohei Kawasaki, Kazuki Ide, Maiko Akutagawa, Hiroshi Yamada, Ono Yutaka, Toshiaki A Furukawa
BACKGROUND: Several recent studies have shown that total scores on depressive symptom measures in a general population approximate an exponential pattern except for the lower end of the distribution. Furthermore, we confirmed that the exponential pattern is present for the individual item responses on the Center for Epidemiologic Studies Depression Scale (CES-D). To confirm the reproducibility of such findings, we investigated the total score distribution and item responses of the Kessler Screening Scale for Psychological Distress (K6) in a nationally representative study...
2017: PeerJ
https://www.readbyqxmd.com/read/28285338/a-study-of-computer-aided-diagnosis-for-pulmonary-nodule-comparison-between-classification-accuracies-using-calculated-image-features-and-imaging-findings-annotated-by-radiologists
#17
Masami Kawagishi, Bin Chen, Daisuke Furukawa, Hiroyuki Sekiguchi, Koji Sakai, Takeshi Kubo, Masahiro Yakami, Koji Fujimoto, Ryo Sakamoto, Yutaka Emoto, Gakuto Aoyama, Yoshio Iizuka, Keita Nakagomi, Hiroyuki Yamamoto, Kaori Togashi
PURPOSE: In our previous study, we developed a computer-aided diagnosis (CADx) system using imaging findings annotated by radiologists. The system, however, requires radiologists to input many imaging findings. In order to reduce such an interaction of radiologists, we further developed a CADx system using derived imaging findings based on calculated image features, in which the system only requires few user operations. The purpose of this study is to check whether calculated image features (CFT) or derived imaging findings (DFD) can represent information in imaging findings annotated by radiologists (AFD)...
March 11, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28284066/successful-treatment-of-proton-pump-inhibitor-induced-sporadic-fundic-gland-polyps-with-an-argon-plasma-coagulator-in-a-patient-with-polycythaemia-vera
#18
Kazuya Kato, Yoshiaki Iwasaki, Masahiko Taniguchi, Kazuhiko Onodera, Takako Kawakami, Minoru Matsuda, Mineko Higuchi, Kimitaka Kato, Yurina Kato, Susumu Tamakawa, Hiroyuki Furukawa
INTRODUCTION: Proton pump inhibitor (PPI) use is associated with the development of fundic gland polyps (FGPs); discontinuing PPIs is associated with regression of FGPs. Here, we report a rare case of non-respondent FGPs after discontinuation of PPI that were successfully treated using an argon plasma coagulator (APC). PRESENTATION OF CASE: We present the case of a 68-year-old woman with a history of polycytheamia vera. She also had gastroesophageal reflux disease (GERD) and had been taking 10 mg of omeprazole daily for the past three years...
February 24, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28283736/phase-1b-study-of-pembrolizumab-mk-3475-anti-pd-1-monoclonal-antibody-in-japanese-patients-with-advanced-melanoma-keynote-041
#19
Naoya Yamazaki, Tatsuya Takenouchi, Manabu Fujimoto, Hironobu Ihn, Hiroshi Uchi, Takashi Inozume, Yoshio Kiyohara, Hisashi Uhara, Kazuhiko Nakagawa, Hiroshi Furukawa, Hidefumi Wada, Kazuo Noguchi, Takashi Shimamoto, Kenji Yokota
PURPOSE: This phase I b study evaluated the safety and anti-tumor activity of pembrolizumab in Japanese patients with advanced melanoma. METHODS: Pembrolizumab (2 mg/kg) was given every 3 weeks (Q3W) for up to 2 years or until confirmed progression or unacceptable toxicity. The tumor response was assessed as per the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) by both investigator review and central review. RESULTS: Forty-two patients with advanced melanoma received pembrolizumab...
March 11, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28280029/complete-chloroplast-genome-sequence-of-the-early-diverging-green-alga-palmophyllum-crassum
#20
Ryo Furukawa, Motoshi Kunugi, Kunio Ihara, Atsushi Takabayashi, Ayumi Tanaka
Palmophyllum crassum is a little-known green alga, with a unique evolutionary position and distinctive photosynthetic features. Here, we present the complete chloroplast genome sequence of Palmophyllum crassum.
March 9, 2017: Genome Announcements
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