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https://www.readbyqxmd.com/read/29050386/brain-monoamine-oxidase-b-and-a-in-human-parkinsonian-dopamine-deficiency-disorders
#1
Junchao Tong, Gausiha Rathitharan, Jeffrey H Meyer, Yoshiaki Furukawa, Lee-Cyn Ang, Isabelle Boileau, Mark Guttman, Oleh Hornykiewicz, Stephen J Kish
See Jellinger (doi:10.1093/awx190) for a scientific commentary on this article. The enzyme monoamine oxidases (B and A subtypes, encoded by MAOB and MAOA, respectively) are drug targets in the treatment of Parkinson's disease. Inhibitors of MAOB are used clinically in Parkinson's disease for symptomatic purposes whereas the potential disease-modifying effect of monoamine oxidase inhibitors is debated. As astroglial cells express high levels of MAOB, the enzyme has been proposed as a brain imaging marker of astrogliosis, a cellular process possibly involved in Parkinson's disease pathogenesis as elevation of MAOB in astrocytes might be harmful...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29046924/liquid-chromatography-mass-spectrometry-with-triazole-bonded-stationary-phase-for-n-methyl-d-aspartate-receptor-related-amino-acids-development-and-application-in-microdialysis-studies
#2
Tatsuya Sakamoto, Riho Onuma, Shoko Furukawa, Akane Hayasaka, Mayu Onozato, Hiromi Nakazawa, Hideaki Iizuka, Hideaki Ichiba, Takeshi Fukushima
We aimed to monitor changes in the levels of amino acid neurotransmitters or neuromodulators simultaneously at the synaptic clefts of experimental animals. We developed a method for the simultaneous determination of the levels of amino acids, such as D-Ser, Gly, and L-Glu, which were involved in neurotransmission via the N-methyl-D-aspartate (NMDA) receptor, and other protein-constituted amino acids in a rat brain microdialysis (MD) sample. We used a liquid chromatography-mass spectrometry (LC-MS)/MS device equipped with a triazole-bonded column...
October 18, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29046507/subretinal-implantation-of-okayama-university-type-retinal-prosthesis-ourep-tm-in-canine-eyes-by-vitrectomy
#3
Toshihiko Matsuo, Tetsuya Uchida, Makoto Nitta, Koichiro Yamashita, Shigiko Takei, Daisuke Ido, Mamoru Tanaka, Masao Oguchi, Toshinori Furukawa
Okayama University-type retinal prosthesis (OUReP(TM)) is a photoelectric dye-coupled polyethylene film which generates electric potential in response to light and stimulates nearby neurons. This study aims to test surgical feasibility of subretinal implantation and functional durability of dye-coupled films in the subretinal space. The dye-coupled films were implanted subretinally by 25-gauge vitrectomy in the right eye of 11 normal beagle dogs: 2 dogs served for film removal after 5-month film implantation, 3 dogs for film removal after 3-month film implantation, 3 dogs for 3-month film implantation and pathological examination, and 3 dogs for sham surgery...
October 18, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29046357/structural-and-thermodynamic-analyses-reveal-critical-features-of-glycopeptide-recognition-by-the-human-pilr%C3%AE-immune-cell-receptor
#4
Atsushi Furukawa, Kosuke Kakita, Tomoki Yamada, Mikihiro Ishizuka, Jiro Sakamoto, Nanao Hatori, Naoyoshi Maeda, Fumina Ohsaka, Takashi Saitoh, Takao Nomura, Kimiko Kuroki, Hisanori Nambu, Hisashi Arase, Shigeki Matsunaga, Masahiro Anada, Toyoyuki Ose, Shunichi Hashimoto, Katsumi Maenaka
Before entering host cells, herpes simplex virus-1 (HSV-1) uses its envelope glycoprotein B (gB) to bind paired immunoglobulin-like type 2 receptor α (PILRα) on immune cells. PILRα belongs to the Siglec (sialic acid (SA)-binding immunoglobulin-like lectin)-like family, members of which bind SA. PILRα is the only Siglec member to recognize not only the sialylated O-linked sugar T antigen (sTn) but also its attached peptide region. We previously determined the crystal structure of PILRα complexed with the sTn-linked glycopeptide of gB, revealing the simultaneous recognition of sTn and peptide by the receptor...
October 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29044129/priming-with-fgf2-stimulates-human-dental-pulp-cells-to-promote-axonal-regeneration-and-locomotor-function-recovery-after-spinal-cord-injury
#5
Kosuke Nagashima, Takahiro Miwa, Hitomi Soumiya, Daisuke Ushiro, Tomoko Takeda-Kawaguchi, Naritaka Tamaoki, Saho Ishiguro, Yumi Sato, Kei Miyamoto, Takatoshi Ohno, Masatake Osawa, Takahiro Kunisada, Toshiyuki Shibata, Ken-Ichi Tezuka, Shoei Furukawa, Hidefumi Fukumitsu
Human dental pulp cells (DPCs), adherent cells derived from dental pulp tissues, are potential tools for cell transplantation therapy. However, little work has been done to optimize such transplantation. In this study, DPCs were treated with fibroblast growth factor-2 (FGF2) for 5-6 consecutive serial passages and were transplanted into the injury site immediately after complete transection of the rat spinal cord. FGF2 priming facilitated the DPCs to promote axonal regeneration and to improve locomotor function in the rat with spinal cord injury (SCI)...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038458/observation-of-current-induced-bulk-magnetization-in-elemental-tellurium
#6
Tetsuya Furukawa, Yuri Shimokawa, Kaya Kobayashi, Tetsuaki Itou
The magnetoelectric effect in bulk matter is of growing interest both fundamentally and technologically. Since the beginning of the century, the magnetoelectric effect has been studied intensively in multiferroic materials. However, magnetoelectric phenomena in materials without any (anti-)ferroic order remain almost unexplored. Here we show the observation of a new class of bulk magnetoelectric effect, by revisiting elemental trigonal tellurium. We demonstrate that elemental tellurium, which is a nonmagnetic semiconductor, exhibits current-induced magnetization...
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29033014/clinicopathologic-features-of-submucosal-esophageal-squamous-cell-carcinoma
#7
Manabu Emi, Jun Hihara, Yoichi Hamai, Takaoki Furukawa, Yuta Ibuki, Morihito Okada
BACKGROUND: The prognoses of submucosal esophageal squamous cell carcinoma patients vary. Patients with favorable prognoses may receive less invasive or nonsurgical interventions, whereas patients with poor prognoses or advanced esophageal cancer may require aggressive treatments. We sought to identify prognostic factors for patients with submucosal esophageal squamous cell carcinoma, focusing on lymph node metastasis and recurrence. METHODS: We included 137 submucosal esophageal squamous cell carcinoma patients who had undergone transthoracic esophagectomy with systematic extended lymph node dissection...
October 12, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29030675/evaluation-of-prognostic-factors-for-esophageal-squamous-cell-carcinoma-treated-with-neoadjuvant-chemoradiotherapy-followed-by-surgery
#8
Yoichi Hamai, Jun Hihara, Manabu Emi, Takaoki Furukawa, Yuji Murakami, Ikuno Nishibuchi, Yuta Ibuki, Ichiko Yamakita, Tomoaki Kurokawa, Yasushi Nagata, Morihito Okada
BACKGROUND: Intensive trimodality therapy is needed for locally advanced esophageal squamous cell carcinoma (ESCC). However, some patients develop recurrence and die of cancer even after trimodality therapy. METHODS: We evaluated prognostic factors based on data from 125 patients with ESCC who underwent neoadjuvant chemoradiotherapy (NCRT) comprising concurrent chemotherapy and 40 Gy of radiation, followed by curative-intent esophagectomy. RESULTS: Thirty-four (27...
October 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29029495/metadherin-promotes-metastasis-by-supporting-putative-cancer-stem-cell-properties-and-epithelial-plasticity-in-pancreatic-cancer
#9
Kensuke Suzuki, Shigetsugu Takano, Hideyuki Yoshitomi, Hitoe Nishino, Shingo Kagawa, Hiroaki Shimizu, Katsunori Furukawa, Masaru Miyazaki, Masayuki Ohtsuka
Pancreatic ductal adenocarcinoma (PDAC) has a high metastatic potential. However, the mechanism of metastatic colonization in PDAC remains poorly understood. Metadherin (MTDH) has emerged in recent years as a crucial mediator of metastasis in several cancer types, although the biological role of MTDH in PDAC has not been investigated. Here, we demonstrated the functional roles of MTDH in PDAC progression, especially focusing on the metastatic cascade. In vitro studies showed that MTDH provides cancer stem cell (CSC) properties in metastatic PDAC cells and contributes to anoikis resistance with epithelial characteristics in PDAC cells...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029036/intracellular-superoxide-level-controlled-by-manganese-superoxide-dismutases-affects-trichothecene-production-in-fusarium-graminearum
#10
Tomohiro Furukawa, Tomoya Yoshinari, Shohei Sakuda
The intracellular superoxide level is a clue to clarification of the regulatory mechanism for mycotoxin production in Fusarium graminearum. In this study, we focused on two manganese superoxide dismutases (SODs) of the fungus, FgSOD2 and FgSOD3, to investigate the relationship of the superoxide level to trichothecene production. Recombinant FgSOD2 and FgSOD3 showed SOD activity, and they were localized mainly in the mitochondria and cytoplasm, respectively. Trichothecene production and mRNA levels of Tri5 and Tri6, which encode a trichothecene biosynthetic enzyme and a key regulator of trichothecene production, respectively, were greatly reduced in gene-deletion mutants of FgSod2 and FgSod3 (ΔFgSod2 and ΔFgSod3)...
October 5, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29027303/increased-maternal-insulin-resistance-promotes-placental-growth-and-decreases-placental-efficiency-in-pregnancies-with-obesity-and-gestational-diabetes-mellitus
#11
Kei Tanaka, Kenji Yamada, Miho Matsushima, Tomoko Izawa, Seishi Furukawa, Yoichi Kobayashi, Mitsutoshi Iwashita
AIM: Homeostasis model assessment for insulin resistance (HOMA-IR) was measured during pregnancy to analyze placental weight and efficiency in relation to maternal insulin resistance. METHODS: A retrospective study of 510 pregnant women (130 with gestational diabetes mellitus [GDM], 380 with normal glucose tolerance) was conducted. We reviewed the patients' demographic data (age, parity, pre-pregnancy body mass index [BMI]) and perinatal outcomes (birth weight, placental weight, BMI at delivery, maternal weight gain, HOMA-IR)...
October 13, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29026578/spontaneous-dissection-limited-to-left-gastric-artery
#12
Masaki Tago, Yoshimasa Oda, Naoko E Furukawa, Shu-Ichi Yamashita
Spontaneous dissection without an aneurysm limited to left gastric artery is fairly rare. Physicians should be alert to the possibility of this condition in patients with sudden-onset abdominal pain.
October 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29023512/the-ultrastructural-characteristics-of-porcine-hepatocytes-donated-after-cardiac-death-and-preserved-with-warm-machine-perfusion-preservation
#13
Hiroki Bochimoto, Naoto Matsuno, Yo Ishihara, Tatsuya Shonaka, Daisuke Koga, Yoshiki Hira, Yuji Nishikawa, Hiroyuki Furukawa, Tsuyoshi Watanabe
The effects of warm machine perfusion preservation of liver grafts donated after cardiac death on the intracellular three-dimensional ultrastructure of the organelles in hepatocytes remain unclear. Here we analyzed comparatively the ultrastructure of the endomembrane systems in porcine hepatocytes under warm ischemia and successive hypothermic and midthermic machine perfusion preservation, a type of the warm machine perfusion. Porcine liver grafts which had a warm ischemia time of 60 minutes were perfused for 4 hours with modified University of Wisconsin gluconate solution...
2017: PloS One
https://www.readbyqxmd.com/read/29023414/3-5-6-7-8-3-4-heptamethoxyflavone-ameliorates-depressive-like-behavior-and-hippocampal-neurochemical-changes-in-chronic-unpredictable-mild-stressed-mice-by-regulating-the-brain-derived-neurotrophic-factor-requirement-for-erk-activation
#14
Atsushi Sawamoto, Satoshi Okuyama, Yoshiaki Amakura, Morio Yoshimura, Takashi Yamada, Hidehiko Yokogoshi, Mitsunari Nakajima, Yoshiko Furukawa
We previously reported that the subcutaneous administration of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), a citrus polymethoxyflavone, attenuated depressive-like behavior and increased the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of a corticosterone-induced depression-like mouse model. We herein demonstrated that (1) HMF was detectable in the brain 10 and 30 min after its oral administration, (2) orally administered HMF improved chronic unpredictable mild stress (CUMS)-induced pathological conditions, including body weight loss and depressive-like behavior, and CUMS-induced neurochemical changes, such as reduction in BDNF expression, decrease in neurogenesis, and decreased level of phosphorylated calcium-calmodulin-dependent protein kinase II in the hippocampus, and (3) these effects of HMF were inhibited by the pre-administration of U0126, a mitogen-activated protein (MAP) kinase inhibitor...
October 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29022200/high-expression-of-the-mitophagy-related-protein-pink1-is-associated-with-a-poor-response-to-chemotherapy-and-a-poor-prognosis-for-patients-treated-with-neoadjuvant-chemotherapy-for-esophageal-squamous-cell-carcinoma
#15
Kotaro Yamashita, Hiroshi Miyata, Tomoki Makino, Yasunori Masuike, Haruna Furukawa, Koji Tanaka, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Makoto Yamasaki, Kiyokazu Nakajima, Shuji Takiguchi, Eiichi Morii, Masaki Mori, Yuichiro Doki
BACKGROUND: Autophagy plays a major role in cellular homeostasis and is implicated in cancer progression. Damaged mitochondria are scavenged and eliminated by mitochondrial autophagy, referred to as mitophagy, which can promote cancer cell survival. This study investigated the expression and effects of the autophagy-related protein LC3 and the mitophagy-related protein Pink1 in human esophageal squamous cell carcinoma (ESCC). METHODS: Both LC3 and Pink1 were analyzed by immunohistochemistry in tissues from 217 ESCC patients, including 159 patients undergoing neoadjuvant chemotherapy...
October 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29021239/an-rna-binding-protein-qki5-regulates-embryonic-neural-stem-cells-through-pre-mrna-processing-in-cell-adhesion-signaling
#16
Yoshika Hayakawa-Yano, Satoshi Suyama, Masahiro Nogami, Masato Yugami, Ikuko Koya, Takako Furukawa, Li Zhou, Manabu Abe, Kenji Sakimura, Hirohide Takebayashi, Atsushi Nakanishi, Hideyuki Okano, Masato Yano
Cell type-specific transcriptomes are enabled by the action of multiple regulators, which are frequently expressed within restricted tissue regions. In the present study, we identify one such regulator, Quaking 5 (Qki5), as an RNA-binding protein (RNABP) that is expressed in early embryonic neural stem cells and subsequently down-regulated during neurogenesis. mRNA sequencing analysis in neural stem cell culture indicates that Qki proteins play supporting roles in the neural stem cell transcriptome and various forms of mRNA processing that may result from regionally restricted expression and subcellular localization...
October 11, 2017: Genes & Development
https://www.readbyqxmd.com/read/28993595/optimization-of-analytical-conditions-for-a-rapid-determination-of-aniline-in-environmental-water-by-liquid-chromatography-tandem-mass-spectrometry
#17
Koji Furukawa, Makoto Hashimoto, Satoshi Kaneco
A rapid determination of aniline in environmental water was examined based on liquid chromatography/tandem mass spectrometry (LC/MS/MS). Environmental water samples were diluted 20-fold with Mill-Q water and measured by LC/MS/MS after adding a surrogate substance (aniline-d5). In the results of the present study, the calibration curve of aniline showed good linearity in the range of 0.05 - 2.0 μg/L. Since the RSD (repeatability) by measuring repeatedly an aniline standard solution (0.05 μg/L, n = 7) was 3...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28992181/requirement-of-glycosylation-machinery-in-toll-like-receptor-responses-revealed-by-crispr-cas9-screening
#18
Ryota Sato, Takuma Shibata, Yu Tanaka, Chiharu Kato, Kiyoshi Yamaguchi, Yoichi Furukawa, Eigo Shimizu, Rui Yamaguchi, Seiya Imoto, Satoru Miyano, Kensuke Miyake
The Toll family of receptors sense microbial products and activate a defense response. The molecular machinery required for the Toll-like receptor (TLR) response is not yet fully understood. In the present study, we used a CRISPR/CAS9 screening system to study TLR responses. We employed a cell line expressing TLR with an NF-κB-driven GFP reporter. The cell line was transduced with a guide RNA library and stimulated with TLR ligands. The cells impaired in GFP induction were sorted, and gRNAs were sequenced...
July 28, 2017: International Immunology
https://www.readbyqxmd.com/read/28984791/sex-determining-region-y-box-9-induces-chemoresistance-in-pancreatic-cancer-cells-by-induction-of-putative-cancer-stem-cell-characteristics-and-its-high-expression-predicts-poor-prognosis
#19
Taku Higashihara, Hideyuki Yoshitomi, Yasuyuki Nakata, Shingo Kagawa, Shigetsugu Takano, Hiroaki Shimizu, Atsushi Kato, Katsunori Furukawa, Masayuki Ohtsuka, Masaru Miyazaki
OBJECTIVES: Pancreatic cancer is a highly chemoresistant tumor and underlying mechanisms are not well understood. Sex determining region Y box 9 (Sox9) is a transcription factor playing important roles on maintenance of pluripotent cells during pancreatic organogenesis. The purpose of this study is to evaluate the roles of Sox9 in pancreatic cancer. METHODS: The Sox9 expression was evaluated by immunohistochemical analysis. Effects of Sox9 inhibition by siRNA or shRNA on chemosensitivity, sphere formation, stem cell markers expression, and in vivo tumor formation rate were examined using pancreatic cancer cell lines...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28984290/role-of-autophagy-in-oncolytic-herpes-simplex-virus-type-1-induced-cell-death-in-squamous-cell-carcinoma-cells
#20
Y Furukawa, A Takasu, Y Yura
Herpes simplex virus type 1 (HSV-1) is one of the most widely studied viruses for oncolytic virotherapy. In squamous cell carcinoma (SCC) cells, the role of autophagy induced by neurovirulence gene-deficient HSV-1s in programmed cell death has not yet been elucidated. The oncolytic HSV-1 strain RH2, which lacks the γ34.5 gene and induces the fusion of human SCC cells, was used. RH2 replicated and induced cell death in SCC cells. RH2 infection was accompanied by the aggregation of microtubule-associated protein 1 light chain 3 (LC3) in the cytoplasm, the conversion of LC3-I to LC3-II and the formation of double-membrane vacuoles containing cell contents...
October 6, 2017: Cancer Gene Therapy
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