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https://www.readbyqxmd.com/read/29457559/functional-outcomes-of-inpatient-rehabilitation-in-very-elderly-patients-with-stroke-differences-across-three-age-groups
#1
Hitoshi Mutai, Tomomi Furukawa, Ayumi Wakabayashi, Akihito Suzuki, Tokiji Hanihara
Background As the population continues to age rapidly, clarifying the factors affecting the prognosis in very elderly stroke patients is essential to enhance the quality of their rehabilitation. Objectives To compare the functional recovery of elderly stroke patients classified into three age groups and to identify the predictors of functional recovery in the very elderly following acute inpatient rehabilitation. Methods Observational study: We collected data on 461 stroke patients in the neurology and neurosurgery ward and classified them into three age groups (65-74, 75-84, and ≥ 85 years)...
February 19, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29457178/enantioselective-aza-friedel-crafts-reaction-of-cyclic-ketimines-with-indoles-using-chiral-imidazoline-phosphoric-acid-catalysts
#2
Shuichi Nakamura, Takashi Furukawa, Tsubasa Hatanaka, Yasuhiro Funahashi
An enantioselective aza-Friedel Crafts reaction of cyclic 4-aryl-3-oxo-1,2,5-thiadiazol-1,1-oxides as cyclic ketimines with indoles was developed. High enantioselectivities were observed for the reaction of various cyclic ketimines with indoles using chiral imidazoline-phosphoric acid catalysts. The obtained products can be converted to chiral α-amino amide and hydantoin.
February 19, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29454358/surgical-resection-for-clinical-stage-i-high-grade-neuroendocrine-carcinoma-of-the-lung
#3
Eisuke Mochizuki, Shun Matsuura, Kyohei Oishi, Koichi Miyashita, Koshiro Ichijyo, Syunya Furukawa, Miyuki Nagaoka, Shinichiro Mikura, Masaru Tsukui, Naoki Koshimizu, Shogo Sakurai, Kazuhiro Asada, Toshihiro Shirai
BACKGROUND: There are few reports about the factor influencing the prognosis of high-grade neuroendocrine carcinoma. In this study, we evaluated surgical outcome of clinical stage I high-grade neuroendocrine carcinoma. METHODS: Patients who underwent curative surgery for high-grade neuroendocrine tumors of the lung in clinical stage I were included in this study. We retrospectively analyzed 27 consecutive patients. The aim of this study was to clarify the clinical course of the disease after surgery and what factors influence the prognosis...
February 17, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29446042/the-clinical-features-of-squamous-cell-lung-carcinoma-with-sensitive-egfr-mutations
#4
Yuri Taniguchi, Yoko Matsumoto, Ryutaro Furukawa, Sayaka Ohara, Kazuhiro Usui
BACKGROUND: The process of selecting patients on the basis of epidermal growth factor receptor (EGFR) mutations would likely result in a patient population with greater sensitivity to EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, EGFR mutation status is not routinely examined in patients with squamous cell lung cancer (Sq) because of the low incidence of EGFR mutations and the poor clinical response to EGFR-TKIs. METHODS: We retrospectively reviewed the clinical features of patients at our hospital with Sq who carried EGFR-TKI-sensitive EGFR mutations and assessed their responses to EGFR-TKIs...
February 14, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29445052/increase-in-breath-hydrogen-concentration-was-correlated-with-the-main-pancreatic-duct-stenosis
#5
Daisuke Sakai, Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Hiroki Suhara, Tomoaki Takeyama, Toshinari Koya, Hiroyuki Tanaka, Tadashi Iida, Ryo Nishio, Hirotaka Suzuki, Kota Uetsuki, Masanobu Matsushita, Takeshi Yamamura, Kazuhiro Furukawa, Kohei Funasaka, Masanao Nakamura, Ryoji Miyahara, Osamu Watanabe, Masatoshi Ishigami, Akihiro Tsuruta, Woosuck Shin, Hidemi Goto
Hydrogen is produced from unabsorbed carbohydrates in the intestine through degradation and metabolism by hydrogenase of intestinal bacteria. The hydrogen is then partially diffused into blood flow and released and detected in exhaled breath. Pancreatic juice production is decreased in patients with reduced pancreatic exocrine function, including those with pancreatic cancer, thus decreasing digestion and absorption of nutrients including carbohydrates, which may increase undigested carbohydrates in the intestine and increase breath hydrogen concentration (BHC)...
February 15, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29443771/endoscopic-bronchial-occlusion-for-postoperative-persistent-bronchopleural-fistula-with-computed-tomography-fluoroscopy-guidance-and-virtual-bronchoscopic-navigation-a-case-report
#6
Masahiro Yanagiya, Jun Matsumoto, Masaaki Nagano, Masashi Kusakabe, Yoko Matsumoto, Ryutaro Furukawa, Sayaka Ohara, Kazuhiro Usui
RATIONALE: The development of postoperative bronchopleural fistula (BPF) remains a challenge in thoracic surgery. We herein report a case of BPF successfully treated with endoscopic bronchial occlusion under computed tomography (CT) fluoroscopy and virtual bronchoscopic navigation (VBN). PATIENT CONCERNS: A 63-year-old man underwent right upper lobectomy with concomitant S6a subsegmentectomy for lung adenocarcinoma. On postoperative day 24, he complained of shaking chills with high fever...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29440276/accurate-depth-of-radiofrequency-induced-lesions-in-renal-sympathetic-denervation-based-on-a-fine-histological-sectioning-approach-in-a-porcine-model
#7
Atsushi Sakaoka, Hisako Terao, Shintaro Nakamura, Hitomi Hagiwara, Toshihito Furukawa, Kiyoshi Matsumura, Kenichi Sakakura
BACKGROUND: Ablation lesion depth caused by radiofrequency-based renal denervation (RDN) was limited to <4 mm in previous animal studies, suggesting that radiofrequency-RDN cannot ablate a substantial percentage of renal sympathetic nerves. We aimed to define the true lesion depth achieved with radiofrequency-RDN using a fine sectioning method and to investigate biophysical parameters that could predict lesion depth. METHODS AND RESULTS: Radiofrequency was delivered to 87 sites in 14 renal arteries from 9 farm pigs at various ablation settings: 2, 4, 6, and 9 W for 60 seconds and 6 W for 120 seconds...
February 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29436609/enhancement-of-malignant-properties-of-human-glioma-cells-by-ganglioside-gd3-gd2
#8
Taiji Iwasawa, Pu Zhang, Yuki Ohkawa, Hiroyuki Momota, Toshihiko Wakabayashi, Yuhsuke Ohmi, Robiul H Bhuiyan, Keiko Furukawa, Koichi Furukawa
Sialic acid-containing glycosphingolipids, gangliosides, are considered as cancer associated antigens in neuro-ectoderm-derived tumors such as melanomas and neuroblastomas. In particular, gangliosides GD3 and GD2 are expressed in human gliomas. It has been reported that their expression levels increase along with increased malignant properties. However, the implication of GD3/GD2 in human glioma cells has never been clarified, at least to the best of our knowledge. In this study, we introduced the cDNA of GD3 synthase (GD3S)(ST8SIA1) into a glioma cell line, U-251MG, that expresses neither GD3 nor GD2, thereby establishing transfectant cells U-251MG-GD3S(+) expressing high levels of GD3 and GD2 on the cell surface...
February 7, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29434290/induction-of-differentiation-of-intrahepatic-cholangiocarcinoma-cells-to-functional-hepatocytes-using-an-organoid-culture-system
#9
Yoshimasa Saito, Toshiaki Nakaoka, Toshihide Muramatsu, Hidenori Ojima, Aoi Sukeda, Yuko Sugiyama, Ryoei Uchida, Ryo Furukawa, Aya Kitahara, Toshiro Sato, Yae Kanai, Hidetsugu Saito
Intrahepatic cholangiocarcinoma (IHCC) is a highly aggressive malignancy with a poor prognosis. It is thought to originate from cholangiocytes, which are the component cells of intrahepatic bile ducts. However, as patients with viral hepatitis often develop IHCC, it has been suggested that transformed hepatocytes may play a role in IHCC development. To investigate whether IHCC cells can be converted to functional hepatocytes, we established organoids derived from human IHCC and cultured them under conditions suitable for hepatocyte differentiation...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29424280/the-peel-of-citrus-kawachiensis-kawachi-bankan-ameliorates-microglial-activation-tau-hyper-phosphorylation-and-suppression-of-neurogenesis-in-the-hippocampus-of-senescence-accelerated-mice
#10
Satoshi Okuyama, Yoshimi Kotani, Kana Yamamoto, Atsushi Sawamoto, Kuniaki Sugawara, Masahiko Sudo, Yuu Ohkubo, Arisa Tamanaha, Mitsunari Nakajima, Yoshiko Furukawa
We previously reported that the dried peel powder of Citrus kawachiensis, one of the citrus products of Ehime, Japan, exerted anti-inflammatory effects in the brain of a lipopolysaccharide-injected systemic inflammation animal model. Inflammation is one of the main mechanisms underlying aging in the brain; therefore, we herein evaluated the anti-inflammatory and other effects of the dried peel powder of C. kawachiensis in the senescence-accelerated mouse-prone 8 (SAMP8) model. The C. kawachiensis treatment inhibited microglial activation in the hippocampus, the hyper-phosphorylation of tau at 231 of threonine in hippocampal neurons, and ameliorated the suppression of neurogenesis in the dentate gyrus of the hippocampus...
February 9, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29423155/successful-surgical-treatment-for-huge-retroperitoneal-liposarcoma-involving-the-pancreas-right-kidney-abdominal-aorta-and-inferior-vena-cava
#11
Mariko Tanaka, Toshiyasu Kawahara, Takahiro Nishikoshi, Masahiro Hagiwara, Koji Imai, Kimiharu Hasegawa, Atsuhiro Koya, Naoto Matsuno, Hidehiro Takei, Nobuyoshi Azuma, Hiroyuki Furukawa
Retroperitoneal liposarcoma is a rare neoplasm that often involves other organs and major blood vessels. Complete surgical resection with negative margins is the only potential curative treatment. Here, we report the case of a patient with a large retroperitoneum liposarcoma that was removed by resection of the descending abdominal aorta and infrahepatic inferior vena cava, right nephrectomy and pancreatoduodenectomy following creation of an extra anatomical femoro-femoral crossover bypass after left axillo-left femoral bypass...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29422450/effect-of-recruitment-methods-on-response-rate-in-a-web-based-study-for-primary-care-physicians-factorial-randomized-controlled-trial
#12
Ryuhei So, Kiyomi Shinohara, Takuya Aoki, Yasushi Tsujimoto, Aya M Suganuma, Toshi A Furukawa
BACKGROUND: Low participation rates are one of the most serious disadvantages of Web-based studies. It is necessary to develop effective strategies to improve participation rates to obtain sufficient data. OBJECTIVE: The objective of this trial was to investigate the effect of emphasizing the incentive in the subject line of the invitation email and the day of the week of sending the invitation email on the participation rate in a Web-based trial. METHODS: We conducted a 2×2 factorial design randomized controlled trial...
February 8, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29417196/engineering-of-the-trichoderma-reesei-xylanase3-promoter-for-efficient-enzyme-expression
#13
Hiroki Hirasawa, Koki Shioya, Takanori Furukawa, Shuji Tani, Jun-Ichi Sumitani, Takashi Kawaguchi, Yasushi Morikawa, Yosuke Shida, Wataru Ogasawara
The GH10 xylanase XYNIII is expressed in the hyper-cellulase-producing mutant PC-3-7, but not in the standard strain QM9414 of Trichoderma reesei. The GH11 xylanase gene xyn1 is induced by cellulosic and xylanosic carbon sources while xyn3 is induced only by cellulosic carbon sources in the PC-3-7 strain. In this study, we constructed a modified xyn3 promoter in which we replaced the cis-acting region of the xyn3 promoter by the cis-acting region of the xyn1 promoter. The resulting xyn3 chimeric promoter exhibited improved inductivity against cellulosic carbon over the wild-type promoter and acquired inductivity against xylanosic carbon...
February 7, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29404501/effect-of-combined-farnesoid-x-receptor-agonist-and-angiotensin-ii-type-1-receptor-blocker-on-hepatic-fibrosis
#14
Tadashi Namisaki, Kei Moriya, Mitsuteru Kitade, Kosuke Takeda, Kosuke Kaji, Yasushi Okura, Naotaka Shimozato, Shinya Sato, Norihisa Nishimura, Kenichiro Seki, Hideto Kawaratani, Hiroaki Takaya, Yasuhiko Sawada, Takemi Akahane, Soichiro Saikawa, Keisuke Nakanishi, Takuya Kubo, Masanori Furukawa, Ryuichi Noguchi, Kiyoshi Asada, Koh Kitagawa, Takahiro Ozutsumi, Yuki Tsuji, Daisuke Kaya, Yukihisa Fujinaga, Hitoshi Yoshiji
The farnesoid X receptor (FXR) agonist, a bile acid-activated nuclear receptor, has been shown to improve the histologic features of nonalcoholic steatohepatitis (NASH); however, a satisfactory effect on hepatic fibrosis has not been achieved. We aimed to investigate the combined effect of FXR agonist and angiotensin II type 1 receptor blocker on hepatic fibrogenesis in rat models of NASH. For 8 weeks, two rat models of NASH were developed. Otsuka Long-Evans Tokushima Fatty (OLETF) rats were administered intraperitoneal injections of 1 mL/kg pig serum (PS) twice a week, whereas Fischer-344 rats were fed a choline-deficient, L-amino acid-defined diet (CDAA)...
November 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29404483/characteristics-of-hepatic-insulin-sensitive-nonalcoholic-fatty-liver-disease
#15
Fumika Shigiyama, Naoki Kumashiro, Yasuhiko Furukawa, Takashi Funayama, Kageumi Takeno, Noritaka Wakui, Takashi Ikehara, Hidenari Nagai, Hikari Taka, Tsutomu Fujimura, Hiroshi Uchino, Yoshifumi Tamura, Hirotaka Watada, Tetsuo Nemoto, Nobuyuki Shiraga, Yasukiyo Sumino, Takahisa Hirose
Nonalcoholic fatty liver disease (NAFLD) plays a crucial role in type 2 diabetes and hepatocellular carcinoma. The major underlying pathogenesis is hepatic insulin resistance. The aim of the present study was to characterize patients with NAFLD with paradoxically normal hepatic insulin sensitivity relative to patients with NAFLD with hepatic insulin resistance. We recruited 26 patients with NAFLD and divided them into three groups ranked by the level of hepatic insulin sensitivity (HIS; high-HIS, mid-HIS, low-HIS), as assessed by the hyperinsulinemic-euglycemic clamp studies using stable isotope...
September 2017: Hepatology communications
https://www.readbyqxmd.com/read/29401490/propionibacterium-acnes-derived-insoluble-immune-complexes-in-sinus-macrophages-of-lymph-nodes-affected-by-sarcoidosis
#16
Yoshimi Suzuki, Keisuke Uchida, Tamiko Takemura, Masaki Sekine, Tomoki Tamura, Asuka Furukawa, Akira Hebisawa, Yumi Sakakibara, Nobuyasu Awano, Tomonari Amano, Daisuke Kobayashi, Mariko Negi, Tomoya Kakegawa, Yuriko Wada, Takashi Ito, Takashige Suzuki, Takumi Akashi, Yoshinobu Eishi
BACKGROUND: Propionibacterium acnes is thought to be a causative agent of sarcoidosis. Patients with sarcoidosis have circulating immune complexes. We attempted to detect P. acnes-derived immune complexes in sarcoid lesions. METHODS: We evaluated formalin-fixed and paraffin-embedded lymph node samples from 38 sarcoidosis patients and 90 non-sarcoidosis patients (27 patients with necrotizing lymphadenitis, 28 patients with reactive lymphadenitis, 16 patients with colon cancer, 19 patients with gastric cancer) by immunohistochemistry using anti-human immunoglobulins (IgG, IgA, and IgM) and complement (C1q and C3c) antibodies, and a P...
2018: PloS One
https://www.readbyqxmd.com/read/29398686/combined-analysis-of-human-and-experimental-murine-samples-identified-novel-circulating-micrornas-as-biomarkers-for-atrial-fibrillation
#17
Yu Natsume, Kasumi Oaku, Kentaro Takahashi, Wakana Nakamura, Ai Oono, Satomi Hamada, Masahiro Yamazoe, Kensuke Ihara, Takeshi Sasaki, Masahiko Goya, Kenzo Hirao, Tetsushi Furukawa, Tetsuo Sasano
BACKGROUND: Recent experimental studies have demonstrated that several microRNAs (miRNAs) expressed in atrial tissue promote a substrate of atrial fibrillation (AF). However, because it has not been fully elucidated whether these experimental data contribute to identifying circulating miRNAs as biomarkers for AF, we used a combined analysis of human serum and murine atrial samples with the aim of identifying these biomarkers for predicting AF.Methods and Results:Comprehensive analyses were performed to screen 733 miRNAs in serum from 10 AF patients and 5 controls, and 672 miRNAs in atrial tissue from 6 inducible atrial tachycardia model mice and 3 controls...
February 5, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29398591/raman-imaging-of-carrier-distribution-in-the-channel-of-an-ionic-liquid-gated-transistor-fabricated-with-regioregular-poly-3-hexylthiophene
#18
Y Wada, I Enokida, J Yamamoto, Y Furukawa
Raman images of carriers (positive polarons) at the channel of an ionic liquid-gated transistor (ILGT) fabricated with regioregular poly(3-hexylthiophene) (P3HT) have been measured with excitation at 785 nm. The observed spectra indicate that carriers generated are positive polarons. The intensities of the 1415 cm-1 band attributed to polarons in the P3HT channel were plotted as Raman images; they showed the carrier density distribution. When the source-drain voltage VD is lower than the source-gate voltage VG (linear region), the carrier density was uniform...
February 2, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29398525/remote-coupled-drastic-%C3%AE-barrel-to-%C3%AE-sheet-transition-of-the-protein-translocation-motor
#19
Arata Furukawa, Shintaro Nakayama, Kunihito Yoshikaie, Yoshiki Tanaka, Tomoya Tsukazaki
The membrane protein SecDF, belonging to the RND superfamily, enhances protein translocation at the extracytoplasmic side using a proton gradient. Here, we report the crystal structure of SecDF in a form we named Super-membrane-facing (Super F) form, demonstrating a β-barrel architecture instead of the previously reported β-sheet structure. Through this structural insight and supporting results of an in vivo crosslinking experiment, we propose a remote coupling model in which a structural change of the transmembrane region drives a functional, extracytoplasmic conformational transition...
January 26, 2018: Structure
https://www.readbyqxmd.com/read/29395450/reconstruction-after-resection-of-carcinoma-of-the-lower-lip
#20
H Imura, H Furukawa, C Sakuma, M Yoshida, N Natsume
No abstract text is available yet for this article.
January 26, 2018: British Journal of Oral & Maxillofacial Surgery
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