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https://www.readbyqxmd.com/read/29225583/item-response-patterns-on-the-patient-health-questionnaire-8-in-a-nationally-representative-sample-of-us-adults
#1
Shinichiro Tomitaka, Yohei Kawasaki, Kazuki Ide, Maiko Akutagawa, Hiroshi Yamada, Ono Yutaka, Toshiaki A Furukawa
Recent studies have shown that item responses on the Center for Epidemiologic Studies Depression Scale (CES-D) and Kessler Screening Scale for Psychological Distress (K6) exhibit the same characteristic item response patterns among the general population. However, the distributional patterns of responses on the Patient Health Questionnaire-8 (PHQ-8) among the general population have not been adequately studied. Thus, we conducted a pattern analysis of PHQ-8 item responses among US adults. Data (18,446 individuals) were obtained from the 2015 Behavioral Risk Factor Surveillance Survey (BRFSS)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29225245/oral-methotrexate-related-lymphoproliferative-disease-presenting-with-severe-osteonecrosis-of-the-jaw-a-case-report-and-literature-review
#2
Sachiko Furukawa, Kazunari Oobu, Masafumi Moriyama, Shintaro Kawano, Saori Sako, Jun-Nosuke Hayashida, Ryota Matsubara, Ken-Ichi Ogata, Tamotsu Kiyoshima, Seiji Nakamura
Long-term methotrexate (MTX) treatment can cause MTX-related lymphoproliferative disorder (MTX-LPD). We experienced a case of MTX-LPD that was associated with severe osteonecrosis of the jaw mimicking medication-related osteonecrosis of the jaw. The patient was an 81-year-old woman with rheumatoid arthritis (RA) who was treated with MTX and bisphosphonate. After 7 years, she was referred to our department for the assessment of giant ulcer and exposure of the alveolar bone of the left maxilla. Histopathological and immunological analyses confirmed a diagnosis of MTX-LPD...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29222951/neuronal-pas-domain-protein-4-npas4-controls-neuronal-homeostasis-in-pentylenetetrazole-induced-epilepsy-through-the-induction-of-homer1a
#3
Wei Shan, Taku Nagai, Motoki Tanaka, Norimichi Itoh, Yoko Furukawa-Hibi, Toshitaka Nabeshima, Masahiro Sokabe, Kiyofumi Yamada
Neuronal intrinsic homeostatic scaling-down of excitatory synapse has been implicated in epilepsy pathogenesis to prevent the neuronal circuits from hyper-excitability. Recent findings suggest a role for neuronal PAS domain protein 4 (Npas4), an activity-dependent neuron-specific transcription factor in epileptogenesis, however, the underlying mechanism by which Npas4 regulates epilepsy remains unclear. We herein propose that limbic seizure activity up-regulates Npas4-homer1a signaling in the hippocampus, thereby contributing to epileptogenesis in mice...
December 9, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29219046/molecular-cloning-and-functional-characterization-of-antimicrobial-peptides-brevinin-1ulf-and-ulmin-1ula-in-the-skin-of-the-newly-classified-ryukyu-brown-frog-rana-ulma
#4
Daisuke Ogawa, Maki Mochitate, Maho Furukawa, Itaru Hasunuma, Tetsuya Kobayashi, Sakae Kikuyama, Shawichi Iwamuro
Antimicrobial peptides (AMPs) were previously isolated from the skin of the Ryukyu brown frog Rana okinavana. However, this species has recently been reclassified as two species, i.e., Rana kobai and Rana ulma. As a result, it was determined that AMPs isolated from R. okinavana were in fact products of R. kobai, but not of R. ulma. In the present study, we collected skin samples from the species R. ulma and cloned twelve cDNAs encoding AMP precursors for the acyclic brevinin-1ULa--1ULf, the temporin-ULa-ULc, ranatuerin-2ULa, japonicin-1ULa, and a novel peptide using reverse-transcription polymerase chain reaction techniques...
December 2017: Zoological Science
https://www.readbyqxmd.com/read/29215088/charcot-marie-tooth-disease-type-2a-with-an-autosomal-recessive-inheritance-the-first-report-of-an-adult-onset-disease
#5
Ryota Hikiami, Hirofumi Yamashita, Natsuko Koita, Naoto Jingami, Nobukatsu Sawamoto, Kaoru Furukawa, Hiromichi Kawai, Tomoya Terashima, Nobuyuki Oka, Akihiro Hashiguchi, Hiroshi Takashima, Makoto Urushitani, Ryosuke Takahashi
Axonal Charcot-Marie-Tooth disease (CMT) is most frequently caused by mutations in the MFN2 gene (CMT2A) that can lead to various clinical phenotypes. The age at disease onset varies, but most cases occur before adolescence. We report two Japanese sisters who presented with middle-age-onset peripheral neuropathy with distinct clinical features. In the affected sisters, a homozygous missense mutation, c.1894C>T, p.R632W, corresponding to the transmembrane domain of MFN2 was identified; this mutation was heterozygous in another non-affected sibling, demonstrating co-segregation of the genotype and phenotype...
November 13, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/29214557/laparoscopic-intraperitoneal-onlay-mesh-for-pediatric-incisional-hernia-a-case-report
#6
Maho Inoue, Shigeyoshi Aoi, Akihiro Taniguchi, Kohei Sakai, Mayumi Higashi, Shigehisa Fumino, Taizo Furukawa, Tatsuro Tajiri
BACKGROUND: The incidence of incisional hernia in pediatric patients is low in comparison with that reported in adults. In the pediatric population, primary closure has generally been favored. However, synthetic or biomedical mesh offers advantages in the repair of larger defects when primary closure is difficult. The use of laparoscopic intraperitoneal onlay mesh (IPOM) in the adult population has been well documented. In the pediatric population, a few laparoscopic approaches with direct suturing have been proposed; however, there are no reports of laparoscopic repair with the use of IPOM...
December 7, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29210629/development-of-a-substrate-identification-method-for-human-scp1-phosphatase-using-phosphorylation-mimic-phage-display
#7
Kodai Otsubo, Takashi Yoneda, Atsushi Kaneko, Seiya Yagi, Kazuhiro Furukawa, Yoshiro Chuman
Protein phosphorylation is strictly regulated by protein kinases and protein phosphatases, and disordered regulation of protein phosphorylation often causes serious diseases, such as cancer. Protein phosphatases are divided into two major groups: tyrosine (Tyr) phosphatases and serine/threonine (Ser/Thr) phosphatases. Substrate trapping mutants are frequently used to characterize Tyr phosphatases and identify their substrates; however, a rapid and simple method to identify substrates for Ser/Thr phosphatases has yet to be developed...
December 5, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29208852/extremely-high-serum-ferritin-an-instrumental-marker-of-masquerading-adult-onset-still-s-disease-with-hemophagocytic-syndrome
#8
Shun Yamashita, Naoko E Furukawa, Tomoyo Matsunaga, Yuka Hirakawa, Masaki Tago, Shu-Ichi Yamashita
BACKGROUND Adult-onset Still's disease (AOSD) is a rare multi-systemic inflammatory disorder of unknown etiology characterized by spiking fever, characteristic rash, and arthritis. It often associates with high serum ferritin levels. CASE REPORT An 88-year-old woman had fever of over 39°C without response to extended-spectrum antibiotics for 6 days. She had non-specific erythema with infiltration on her trunk. She had leukocytosis with neutrophilia of 80%, mild hepatic dysfunction, normal level of rheumatoid factor and antinuclear antibody, thrombocytopenia, elevated d-dimer and soluble interleukin2 receptor, extremely high serum ferritin (78 662 ng/mL), and splenomegaly...
December 6, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29205334/sodium-glucose-cotransporter-2-inhibitor-canagliflozin-attenuates-liver-cancer-cell-growth-and-angiogenic-activity-by-inhibiting-glucose-uptake
#9
Kosuke Kaji, Norihisa Nishimura, Kenichiro Seki, Shinya Sato, Soichiro Saikawa, Keisuke Nakanishi, Masanori Furukawa, Hideto Kawaratani, Mitsuteru Kitade, Kei Moriya, Tadashi Namisaki, Hitoshi Yoshiji
Sodium-glucose cotransporter 2 inhibitors (SGLT2-Is) comprise a new class of antidiabetic agents that inhibit glucose reabsorption in the renal proximal tubules. Although a recent report demonstrated the potential ability of SGLT2-Is to attenuate cancer growth of SGLT2-expressing cancer cells, little is known about the effects of SGLT2-Is on hepatocellular carcinoma (HCC). Here, we investigate the anti-cancer properties of a SGLT2-I, canagliflozin, against human liver cancer cells. SGTL2 mRNA and protein expression were detected in Huh7 and HepG2 cells, although not in HLE as well as primary human hepatocytes and hepatic stellate cells...
December 4, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29204670/polymyxin-b-immobilized-hemoperfusion-and-mortality-in-critically-ill-adult-patients-with-sepsis-septic-shock-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#10
REVIEW
Tomoko Fujii, Riki Ganeko, Yuki Kataoka, Toshi A Furukawa, Robin Featherstone, Kent Doi, Jean-Louis Vincent, Daniela Pasero, René Robert, Claudio Ronco, Sean M Bagshaw
PURPOSE: Polymyxin B-immobilized hemoperfusion (PMX-HP) is an adjuvant therapy for sepsis or septic shock that clears circulating endotoxin. Prior trials have shown that PMX-HP improves surrogate endpoints. We aimed to conduct an evidence synthesis to evaluate the efficacy and safety of PMX-HP in critically ill adult patients with sepsis or septic shock. METHODS: We searched for randomized controlled trials (RCTs) in MEDLINE, EMBASE, the Cochrane Library, the Health Technology Assessment Database, CINAHL, "Igaku Chuo Zasshi", the National Institute of Health Clinical Trials Register, the World Health Organization International Clinical Trials Registry Platform, the University Hospital Medical Information Network Clinical Trials Registry, the reference lists of retrieved articles, and publications by manufacturers of PMX-HP...
December 4, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29204055/combined-treatment-of-pancreatic-cancer-xenograft-with-90y-itga6b4-mediated-radioimmunotherapy-and-pi3k-mtor-inhibitor
#11
Winn Aung, Atsushi B Tsuji, Hitomi Sudo, Aya Sugyo, Yoshinori Ukai, Katsushi Kouda, Yoshikazu Kurosawa, Takako Furukawa, Tsuneo Saga, Tatsuya Higashi
AIM: To investigate the therapeutic effect of combined integrin α6β4-targeted radioimmunotherapy (RIT) and PI3K/mTOR inhibitor BEZ235 in a pancreatic cancer model. METHODS: Phosphorylation of Akt, mTOR, the downstream effectors eukaryotic initiation factor 4E binding protein 1 (4EBP1) and S6 ribosomal protein (S6) were evaluated in BxPC-3 human pancreatic cancer cells treated with Yttrium-90 (90Y) labeled anti-integrin α6β4 antibody (ITGA6B4) and BEZ235 by western blotting...
November 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29203794/behavioral-impairment-in-shati-nat8l-knockout-mice-via-dysfunction-of-myelination-development
#12
Kazuyuki Sumi, Kyosuke Uno, Hiroshi Noike, Takenori Tomohiro, Yasumaru Hatanaka, Yoko Furukawa-Hibi, Toshitaka Nabeshima, Yoshiaki Miyamoto, Atsumi Nitta
We have identified SHATI/NAT8L in the brain of mice treated with methamphetamine. Recently, it has been reported that SHATI is N-acetyltransferase 8-like protein (NAT8L) that produces N-acetylaspatate (NAA) from aspartate and acetyl-CoA. We have generated SHATI/NAT8L knockout (Shati -/-) mouse which demonstrates behavioral deficits that are not rescued by single NAA supplementation, although the reason for which is still not clarified. It is possible that the developmental impairment results from deletion of SHATI/NAT8L in the mouse brain, because NAA is involved in myelination through lipid synthesis in oligodendrocytes...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29200154/rhinocerebral-mucormycosis-with-temporal-artery-thrombosis-in-an-adolescent-following-hla-haploidentical-stem-cell-transplantation
#13
Yuta Kawahara, Shoya Wada, Hitomi Nijima, Tomomi Hayase, Rieko Furukawa, Kentaro Ashizawa, Akira Morimoto
Rhinocerebral mucormycosis (RCM) can lead to internal carotid artery thrombosis. Here, we report the first case of RCM with temporal artery thrombosis following HLA-haploidentical stem cell transplantation in an adolescent presenting with low-grade fever, right mandibular pain, and right jaw claudication. This case suggests that RCM can cause temporal artery thrombosis and should be considered as a differential diagnosis in severely immunocompromised patients with maxillary sinusitis presenting with jaw claudication...
December 1, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29195110/brachial-artery-diameter-as-a-marker-for-cardiovascular-risk-assessment-fmd-j-study
#14
Tatsuya Maruhashi, Junko Soga, Noritaka Fujimura, Naomi Idei, Shinsuke Mikami, Yumiko Iwamoto, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Nozomu Oda, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yoshiki Aibara, Farina Mohamad Yusoff, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Ayumu Nakashima, Chikara Goto, Hirofumi Tomiyama, Bonpei Takase, Takahide Kohro, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Kentaro Watanabe, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Ito, Hisao Ikeda, Akira Yamashina, Yukihito Higashi
BACKGROUND AND AIMS: Baseline brachial artery (BBA) diameter has been reported to be a potential confounding factor of flow-mediated vasodilation (FMD). The purpose of this study was to evaluate the relationships between BBA diameter and cardiovascular risk factors and compare the diagnostic accuracy of BBA diameter in subjects without cardiovascular risk factors and patients with cardiovascular disease (CVD) with that of FMD. METHODS: We measured BBA diameter and FMD in 5695 male subjects...
November 22, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29194985/a-multiplex-reverse-transcription-pcr-and-automated-electronic-microarray-assay-for-detection-and-differentiation-of-seven-viruses-affecting-swine
#15
A Erickson, M Fisher, T Furukawa-Stoffer, A Ambagala, D Hodko, J Pasick, D P King, C Nfon, R Ortega Polo, O Lung
Microarray technology can be useful for pathogen detection as it allows simultaneous interrogation of the presence or absence of a large number of genetic signatures. However, most microarray assays are labour-intensive and time-consuming to perform. This study describes the development and initial evaluation of a multiplex reverse transcription (RT)-PCR and novel accompanying automated electronic microarray assay for simultaneous detection and differentiation of seven important viruses that affect swine (foot-and-mouth disease virus [FMDV], swine vesicular disease virus [SVDV], vesicular exanthema of swine virus [VESV], African swine fever virus [ASFV], classical swine fever virus [CSFV], porcine respiratory and reproductive syndrome virus [PRRSV] and porcine circovirus type 2 [PCV2])...
November 30, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29194817/porphyrin-based-air-stable-helical-radicals
#16
Atsuhiro Osuka, Kenichi Kato, Ko Furukawa, Tadashi Mori
Stable helical radicals are promising multi-functional molecules in light of intriguing magnetic and chiroptical properties. Attempts were made to extend diphenylmethyl-fused NiII porphyrin radical to helical system as the first air-stable organic neutral helical radicals. Intramolecular Pd-catalyzed twofold C-H arylation of methyl- or methoxy-introduced meso-diphenylmethyl NiII porphyrins gave a mixture of the target and rearranged radicals. Oxidative fusion reaction of meso-(bis(1-naphthyl)methyl) NiII porphyrins provided doubly fused NiII porphyrin radicals...
November 30, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29191877/response-to-comment-on-water-harvesting-from-air-with-metal-organic-frameworks-powered-by-natural-sunlight
#17
Hyunho Kim, Sameer R Rao, Shankar Narayanan, Eugene A Kapustin, Sungwoo Yang, Hiroyasu Furukawa, Ari S Umans, Omar M Yaghi, Evelyn N Wang
In their comment, Bui et al argue that the approach we described in our report is vastly inferior in efficiency to alternative off-the-shelf technologies. Their conclusion is invalid, as they compare efficiencies in completely different operating conditions. Here, using heat transfer and thermodynamics principles, we show how Bui et al's conclusions about the efficiencies of off-the-shelf technologies are fundamentally flawed and inaccurate for the operating conditions described in our study.
December 1, 2017: Science
https://www.readbyqxmd.com/read/29184117/context-dependent-effect-of-reverberation-on-material-perception-from-impact-sound
#18
Takuya Koumura, Shigeto Furukawa
Our hearing is usually robust against reverberation. This study asked how such robustness to daily sound is realized, and what kinds of acoustic cues contribute to the robustness. We focused on the perception of materials based on impact sounds, which is a common daily experience, and for which the responsible acoustic features have already been identified in the absence of reverberation. In our experiment, we instructed the participants to identify materials from impact sounds with and without reverberation...
November 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29183343/primary-and-metastatic-cardiac-tumors-echocardiographic-diagnosis-treatment-and-prognosis-in-a-15-years-single-center-study
#19
Natsumi Nomoto, Tomoko Tani, Toshiko Konda, Kitae Kim, Takeshi Kitai, Mitsuhiko Ota, Shuichiro Kaji, Yukihiro Imai, Yukikatsu Okada, Yutaka Furukawa
BACKGROUND: The frequency of primary cardiac tumors is rare at about 0.3% by autopsy. Our objective was to investigate the characteristics and locations of cardiac tumors and to provide a prognostic analysis in our hospital. METHODS: We collected data on 95 patients with echocardiographic diagnosis or detection of cardiac tumors in a prospective analysis from 1999 to 2014. The median follow-up period was 43 months (0.5-183 months). RESULTS: The subjects included 56 men and 39 women with a mean age of 65 years...
November 28, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29183133/distribution-of-human-papillomavirus-genotype-in-anal-condyloma-acuminatum-among-japanese-men-the-higher-prevalence-of-high-risk-human-papillomavirus-in-men-who-have-sex-with-men-with-hiv-infection
#20
Satomi Furukawa, Shin Uota, Tetsuo Yamana, Rikisaburo Sahara, Kuniko Iihara, Yoshiyuki Yokomaku, Yasumasa Iwatani, Wataru Sugiura
Human papillomavirus (HPV) infection is known to cause anal condyloma acuminatum (CA) and squamous cell carcinoma. Men who have sex with men (MSM) with human immunodeficiency virus (HIV) infection are frequently co-infected with HPV, especially high risk HPV (HR-HPV) that causes anal squamous cell carcinoma. However, there are few reports of HPV genotype studies in anal lesion of Japanese men. We tried to estimate the distribution of HPV genotypes in anal CA tissue specimens from the Japanese men in order to elucidate the risk of anal cancer...
November 28, 2017: AIDS Research and Human Retroviruses
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