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https://www.readbyqxmd.com/read/28325654/the-year-in-cardiothoracic-critical-care-selected-highlights-from-2016
#1
REVIEW
Jacob T Gutsche, Kamrouz Ghadimi, John G T Augoustides, Adam Evans, Hanjo Ko, Menachem Weiner, Jesse Raiten, Meghan Lane-Fall, Emily Gordon, Pavan Atluri, Rita Milewski, Jiri Horak, Prakash Patel, Harish Ramakrishna
No abstract text is available yet for this article.
January 10, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28314504/low-ejection-fraction-in-donor-hearts-is-not-directly-associated-with-increased-recipient-mortality
#2
Carol W Chen, Michael H Sprys, Ann C Gaffey, Jennifer J Chung, Kenneth B Margulies, Michael A Acker, Pavan Atluri
BACKGROUND: Reduced left ventricular ejection fraction (EF) in the donor heart is often a contraindication for transplant. However, small studies have validated the use of hearts with evidence of myocardial dysfunction to boost the number of organs available for transplant. We hypothesize that donor hearts with reduced EF undergo myocardial recovery after transplant and result in equivalent recipient survival compared with grafts with normal function. METHODS: We examined post-operative outcomes of heart recipients in the database of the United Network for Organ Sharing...
February 4, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28258242/successful-cardiac-transplantation-outcomes-in-patients-with-adult-congenital-heart-disease
#3
Jonathan N Menachem, Jessica R Golbus, Maria Molina, Jeremy A Mazurek, Nicole Hornsby, Pavan Atluri, Stephanie Fuller, Edo Y Birati, Yuli Y Kim, Lee R Goldberg, Joyce W Wald
OBJECTIVES: The purpose of our study is (1) to characterise patients with congenital heart disease undergoing heart transplantation by adult cardiac surgeons in a large academic medical centre and (2) to describe successful outcomes associated with our multidisciplinary approach to the evaluation and treatment of adults with congenital heart disease (ACHD) undergoing orthotopic heart transplantation (OHT). BACKGROUND: Heart failure is the leading cause of death in patients with ACHD leading to increasing referrals for OHT...
March 3, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28242019/gone-fishing-looking-to-catch-some-answers-for-differing-mortality-in-the-corevalve-high-risk-trial
#4
EDITORIAL
Arman Kilic, Pavan Atluri
No abstract text is available yet for this article.
February 3, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28226332/responsible-safe-and-effective-prescription-of-opioids-for-chronic-non-cancer-pain-american-society-of-interventional-pain-physicians-asipp-guidelines
#5
Laxmaiah Manchikanti, Adam M Kaye, Nebojsa Nick Knezevic, Heath McAnally, Konstantin Slavin, Andrea M Trescot, Susan Blank, Vidyasagar Pampati, Salahadin Abdi, Jay S Grider, Alan D Kaye, Kavita N Manchikanti, Harold Cordner, Christopher G Gharibo, Michael E Harned, Sheri L Albers, Sairam Atluri, Steve M Aydin, Sanjay Bakshi, Robert L Barkin, Ramsin M Benyamin, Mark V Boswell, Ricardo M Buenaventura, Aaron K Calodney, David L Cedeno, Sukdeb Datta, Timothy R Deer, Bert Fellows, Vincent Galan, Vahid Grami, Hans Hansen, Standiford Helm Ii, Rafael Justiz, Dhanalakshmi Koyyalagunta, Yogesh Malla, Annu Navani, Kent H Nouri, Ramarao Pasupuleti, Nalini Sehgal, Sanford M Silverman, Thomas T Simopoulos, Vijay Singh, Daneshvari R Solanki, Peter S Staats, Ricardo Vallejo, Bradley W Wargo, Arthur Watanabe, Joshua A Hirsch
BACKGROUND: Opioid use, abuse, and adverse consequences, including death, have escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse, numerous regulations and guidelines for responsible opioid prescribing have been developed by various organizations. However, the US opioid epidemic is continuing and drug dose deaths tripled during 1999 to 2015. Recent data show a continuing increase in deaths due to natural and semisynthetic opioids, a decline in methadone deaths, and an explosive increase in the rates of deaths involving other opioids, specifically heroin and illicit synthetic fentanyl...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28176387/bridge-with-a-left-ventricular-assist-device-to-a-simultaneous-heart-and-kidney-transplant-review-of-the-united-network-for-organ-sharing-database
#6
Ann C Gaffey, Carol W Chen, Jennifer Chung, Edward Wilson Grandin, Paige M Porrett, Michael A Acker, Pavan Atluri
BACKGROUND: Left ventricular assist device (LVAD) implantation as a bridge to cardiac transplantation (BTT) is an effective treatment for end-stage heart failure patients. Currently, there is an increasing number of patients with a LVAD who need a heart and kidney transplant (HKT). Little is known of the prognostic outcomes in these patients. This study was undertaken to determine whether an equivalent outcome would be present in HKTs as compared to a non-LVAD primary HKT cohort. METHODS: We reviewed the United Network for Organ Sharing database from 2004 to 2013...
February 8, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28168663/engineered-nanomaterials-their-physicochemical-characteristics-and-how-to-measure-them
#7
Rambabu Atluri, Keld Alstrup Jensen
Numerous types of engineered nanomaterials (ENMs) are commercially available and developments move towards producing more advanced nanomaterials with tailored properties. Such advanced nanomaterials may include chemically doped or modified derivatives with specific surface chemistries; also called higher generation or multiconstituent nanomaterials. To fully enjoy the benefits of nanomaterials, appropriate characterisation of ENMs is necessary for many aspects of their production, use, testing and reporting to regulatory bodies...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28063981/macrophage-activation-status-determines-the-internalization-of-mesoporous-silica-particles-of-different-sizes-exploring-the-role-of-different-pattern-recognition-receptors
#8
Audrey Gallud, Olesja Bondarenko, Neus Feliu, Natalia Kupferschmidt, Rambabu Atluri, Alfonso Garcia-Bennett, Bengt Fadeel
Mesoporous silica-based particles are promising candidates for biomedical applications. Here, we address the importance of macrophage activation status for internalization of AMS6 (approx. 200 nm in diameter) versus AMS8 (approx. 2 μm) mesoporous silica particles and the role of different phagocytosis receptors for particle uptake. To this end, FITC-conjugated silica particles were used. AMS8 were found to be non-cytotoxic both for M-CSF-stimulated (anti-inflammatory) and GM-CSF-stimulated (pro-inflammatory) macrophages, whereas AMS6 exhibited cytotoxicity towards M-CSF-stimulated, but not GM-CSF-stimulated macrophages; this toxicity was, however, mitigated in the presence of serum...
March 2017: Biomaterials
https://www.readbyqxmd.com/read/28003575/higher-body-mass-index-increases-risk-of-heartmate-ii-pump-thrombosis-but-does-not-adversely-affect-long-term-survival
#9
Jason J Han, Renganaden Sooppan, Adam P Johnson, Carol W Chen, Ann C Gaffey, Emily C Phillips, Jessica Howard, J Eduardo Rame, Michael A Acker, Pavan Atluri
BACKGROUND: Obesity has been correlated with various adverse events in patients who receive left ventricular assist devices (LVAD). In this study, we sought to further characterize the role of obesity in this patient population.Methods and Results:We performed a retrospective analysis of 164 patients implanted with a HeartMate II from August 2008 to December 2014. Patients were categorized into 2 BMI groups based on WHO guidelines: BMI 18.5-30 kg/m(2)(n=99) and BMI >30 kg/m(2)(n=65)...
January 25, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27997133/injectable-guest-host-assembled-polyethylenimine-hydrogel-for-sirna-delivery
#10
Leo L Wang, Janna N Sloand, Ann C Gaffey, Chantel M Venkataraman, Zhichun Wang, Alen Trubelja, Daniel A Hammer, Pavan Atluri, Jason A Burdick
While siRNA has tremendous potential for therapeutic applications, advancement is limited by poor delivery systems. Systemically, siRNAs are rapidly degraded, may have off-target silencing, and necessitate high working concentrations. To overcome this, we developed an injectable, guest-host assembled hydrogel between polyethylenimine (PEI) and polyethylene glycol (PEG) for local siRNA delivery. Guest-host modified polymers assembled with siRNAs to form polyplexes that had improved transfection and viability compared to PEI...
December 20, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/27990501/mcrave-continuous-estimation-of-craving-during-smoking-cessation
#11
Soujanya Chatterjee, Karen Hovsepian, Hillol Sarker, Nazir Saleheen, Mustafa al'Absi, Gowtham Atluri, Emre Ertin, Cho Lam, Andrine Lemieux, Motohiro Nakajima, Bonnie Spring, David W Wetter, Santosh Kumar
Craving usually precedes a lapse for impulsive behaviors such as overeating, drinking, smoking, and drug use. Passive estimation of craving from sensor data in the natural environment can be used to assist users in coping with craving. In this paper, we take the first steps towards developing a computational model to estimate cigarette craving (during smoking abstinence) at the minute-level using mobile sensor data. We use 2,012 hours of sensor data and 1,812 craving self-reports from 61 participants in a smoking cessation study...
September 2016: Proceedings of the ACM International Conference on Ubiquitous Computing
https://www.readbyqxmd.com/read/27774054/tmseeg-a-matlab-based-graphical-user-interface-for-processing-electrophysiological-signals-during-transcranial-magnetic-stimulation
#12
Sravya Atluri, Matthew Frehlich, Ye Mei, Luis Garcia Dominguez, Nigel C Rogasch, Willy Wong, Zafiris J Daskalakis, Faranak Farzan
Concurrent recording of electroencephalography (EEG) during transcranial magnetic stimulation (TMS) is an emerging and powerful tool for studying brain health and function. Despite a growing interest in adaptation of TMS-EEG across neuroscience disciplines, its widespread utility is limited by signal processing challenges. These challenges arise due to the nature of TMS and the sensitivity of EEG to artifacts that often mask TMS-evoked potentials (TEP)s. With an increase in the complexity of data processing methods and a growing interest in multi-site data integration, analysis of TMS-EEG data requires the development of a standardized method to recover TEPs from various sources of artifacts...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27756463/off-pump-ventricular-assist-device-implantation-easy-as-1-2-3
#13
EDITORIAL
Arman Kilic, Pavan Atluri
No abstract text is available yet for this article.
January 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27726874/transdifferentiation-a-new-frontier-in-cardiovascular-cell-therapy
#14
EDITORIAL
Michael Ibrahim, Pavan Atluri
No abstract text is available yet for this article.
January 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27717422/left-ventricular-assist-device-design-reduces-von-willebrand-factor-degradation-a-comparative-study-between-the-heartmate-ii-and-the-evaheart-left-ventricular-assist-system
#15
Carlo R Bartoli, Jooeun Kang, David Zhang, Jessica Howard, Michael Acker, Pavan Atluri, Tadashi Motomura
BACKGROUND: Supraphysiologic shear stress from continuous-flow left ventricular assist devices (LVADs) accelerates von Willebrand factor (vWF) degradation and predisposes patients to nonsurgical bleeding. It is unknown whether unique design characteristics of LVADs differentially affect vWF degradation. We tested the hypothesis that the centrifugal-flow EVAHEART (Evaheart, Houston, TX) left ventricular assist system (LVAS), which was designed to minimize shear stress (low operational revolutions per minute [rpm], larger flow gaps, low shear stress, flat H-Q curve), reduced vWF degradation versus the axial-flow HeartMate II (Thoratec, Pleasanton, CA) LVAD...
October 4, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27706263/gene-activated-titanium-surfaces-promote-in-vitro-osteogenesis
#16
Keerthi Atluri, Joun Lee, Denise Seabold, Satheesh Elangovan, Aliasger K Salem
PURPOSE: Commercially pure titanium (CpTi) and its alloys possess favorable mechanical and biologic properties for use as implants in orthopedics and dentistry. However, failures in osseointegration still exist and are common in select individuals with risk factors such as smoking. Therefore, in this study, a proposal was made to enhance the potential for osseointegration of CpTi discs by coating their surfaces with nanoplexes comprising polyethylenimine (PEI) and plasmid DNA (pDNA) encoding bone morphogenetic protein-2 (pBMP-2)...
March 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/27621622/development-of-timp1-magnetic-nanoformulation-for-regulation-of-synaptic-plasticity-in-hiv-1-infection
#17
Venkata Subba Rao Atluri, Rahul Dev Jayant, Sudheesh Pilakka-Kanthikeel, Gabriella Garcia, Thangavel Samikkannu, Adriana Yndart, Ajeet Kaushik, Madhavan Nair
Although the introduction of antiretroviral therapy has reduced the prevalence of severe forms of neurocognitive disorders, human immunodeficiency virus (HIV)-1-associated neurocognitive disorders were observed in 50% of HIV-infected patients globally. The blood-brain barrier is known to be impermeable to most of antiretroviral drugs. Successful delivery of antiretroviral drugs into the brain may induce an inflammatory response, which may further induce neurotoxicity. Therefore, alternate options to antiretroviral drugs for decreasing the HIV infection and neurotoxicity may help in reducing neurocognitive impairments observed in HIV-infected patients...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27583217/evaluation-of-surface-detail-reproduction-dimensional-stability-and-gypsum-compatibility-of-monophase-polyvinyl-siloxane-and-polyether-elastomeric-impression-materials-under-dry-and-moist-conditions
#18
Sriharsha Babu Vadapalli, Kaleswararao Atluri, Madhu Sudhan Putcha, Sirisha Kondreddi, N Suman Kumar, Durga Prasad Tadi
OBJECTIVES: This in vitro study was designed to compare polyvinyl-siloxane (PVS) monophase and polyether (PE) monophase materials under dry and moist conditions for properties such as surface detail reproduction, dimensional stability, and gypsum compatibility. MATERIALS AND METHODS: Surface detail reproduction was evaluated using two criteria. Dimensional stability was evaluated according to American Dental Association (ADA) specification no. 19. Gypsum compatibility was assessed by two criteria...
July 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/27544289/valve-selection-in-end-stage-renal-disease-should-it-always-be-biological
#19
Matthew L Williams, Joseph E Bavaria, Michael A Acker, Nimesh D Desai, Prashanth Vallabhajosyula, W Clark Hargrove, Pavan Atluri, Wilson Y Szeto
BACKGROUND: When valve replacement is required in patients with end-stage renal disease (ESRD), it is not clear if mechanical or bioprosthetic valve selection is better. We compared outcomes between ESRD patients who underwent either mechanical or biologic valve replacements at our institution. METHODS: All patients with ESRD who underwent either mitral or aortic valve replacement from 2002 to 2014 at our institution were reviewed (n = 215; mechanical = 64, biological = 151)...
November 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27535703/hiv-and-cocaine-impact-glial-metabolism-energy-sensor-amp-activated-protein-kinase-role-in-mitochondrial-biogenesis-and-epigenetic-remodeling
#20
Thangavel Samikkannu, Venkata S R Atluri, Madhavan P N Nair
HIV infection and cocaine use have been identified as risk factors for triggering neuronal dysfunction. In the central nervous system (CNS), energy resource and metabolic function are regulated by astroglia. Glia is the major reservoir of HIV infection and disease progression in CNS. However, the role of cocaine in accelerating HIV associated energy deficit and its impact on neuronal dysfunction has not been elucidated yet. The aim of this study is to elucidate the molecular mechanism of HIV associated neuropathogenesis in cocaine abuse and how it accelerates the energy sensor AMPKs and its subsequent effect on mitochondrial oxidative phosphorylation (OXPHOS), BRSKs, CDC25B/C, MAP/Tau, Wee1 and epigenetics remodeling complex SWI/SNF...
2016: Scientific Reports
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