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https://www.readbyqxmd.com/read/28880907/comparison-of-electrochemical-skin-conductance-and-vibration-perception-threshold-measurement-in-the-detection-of-early-diabetic-neuropathy
#1
Amit Goel, Channabasappa Shivaprasad, Anish Kolly, Vijaya Sarathi H A, Sridevi Atluri
The early diagnosis of diabetic peripheral neuropathy (DPN) is challenging. Sudomotor dysfunction is one of the earliest detectable abnormalities in DPN. The present study aimed to determine the diagnostic performance of the electrochemical skin conductance (ESC) test in detecting early DPN, compared with the vibration perception threshold (VPT) test and diabetic neuropathy symptom (DNS) score, using the modified neuropathy disability score (NDS) as the reference standard. Five hundred and twenty-three patients with type 2 diabetes underwent an NDS-based clinical assessment for neuropathy...
2017: PloS One
https://www.readbyqxmd.com/read/28864381/cardiac-metastasis-as-initial-site-of-recurrence-in-rectal-cancer
#2
Praveen Namireddy, Prashanti Atluri, Hazaim Alwair, John Cahill, Mahvish Muzaffar
No abstract text is available yet for this article.
August 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28840469/early-exposure-to-ketamine-impairs-axonal-pruning-in-developing-mouse-hippocampus
#3
Aleksandar Lj Obradovic, Navya Atluri, Lorenza Dalla Massara, Azra Oklopcic, Nikola S Todorovic, Gaurav Katta, Hari P Osuru, Vesna Jevtovic-Todorovic
Mounting evidence suggests that prolonged exposure to general anesthesia (GA) during brain synaptogenesis damages the immature neurons and results in long-term neurocognitive impairments. Importantly, synaptogenesis relies on timely axon pruning to select axons that participate in active neural circuit formation. This process is in part dependent on proper homeostasis of neurotrophic factors, in particular brain-derived neurotrophic factor (BDNF). We set out to examine how GA may modulate axon maintenance and pruning and focused on the role of BDNF...
August 24, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28816726/acute-inflammatory-demyelinating-polyradiculoneuropathy-secondary-to-ifosfamide
#4
Mahvish Muzaffar, Prashanti M Atluri, Darla Liles
No abstract text is available yet for this article.
August 8, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/28792504/common-gene-network-signature-of-different-neurological-disorders-and-their-potential-implications-to-neuroaids
#5
Vidya Sagar, S Pilakka-Kanthikeel, Paola C Martinez, V S R Atluri, M Nair
The neurological complications of AIDS (neuroAIDS) during the infection of human immunodeficiency virus (HIV) are symptomized by non-specific, multifaceted neurological conditions and therefore, defining a specific diagnosis/treatment mechanism(s) for this neuro-complexity at the molecular level remains elusive. Using an in silico based integrated gene network analysis we discovered that HIV infection shares convergent gene networks with each of twelve neurological disorders selected in this study. Importantly, a common gene network was identified among HIV infection, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and age macular degeneration...
2017: PloS One
https://www.readbyqxmd.com/read/28762183/novel-nanoformulation-to-mitigate-co-effects-of-drugs-of-abuse-and-hiv-1-infection-towards-the-treatment-of-neuroaids
#6
Rahul Dev Jayant, Venkata S R Atluri, Sneham Tiwari, Sudheesh Pilakka-Kanthikeel, Ajeet Kaushik, Adriana Yndart, Madhavan Nair
Drug abuse (e.g., methamphetamine-Meth or cocaine-Coc) is one of the major risk factors for becoming infected with HIV-1, and studies show that in combination, drug abuse and HIV-1 lead to significantly greater damage to CNS. To overcome these issues, we have developed a novel nanoformulation (NF) for drug-abusing population infected with HIV-1. In this work, a novel approach was developed for the co-encapsulation of Nelfinavir (Nel) and Rimcazole (Rico) using layer-by-layer (LbL) assembled magnetic nanoformulation for the cure of neuroAIDS...
July 31, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28760470/improved-approach-with-subcostal-exchange-of-the-heartmate-ii-left-ventricular-assist-device-difference-in-on-and-off-pump
#7
Ann C Gaffey, Carol W Chen, Jennifer J Chung, Emily Phillips, Joyce Wald, Matthew L Williams, David W Low, Michael A Acker, Pavan Atluri
BACKGROUND: The HeartMate II (St. Jude Medical, Inc, St. Paul, MN [previously Thoratec]) left ventricular assist device (LVAD) exchange has traditionally involved a redo sternotomy. Alternate minimally invasive subcostal approaches have the advantage of avoiding sternal reentry, excessive bleeding, and prolonged recovery. METHODS: This retrospective review included patients who underwent an exchange from May 2009 to March 2016. The patients were divided into three cohorts: (1) redo sternotomy, (2) subcostal approach involving cardiopulmonary bypass (CPB) (ON-CPB SC), and (3) subcostal approach off the CPB pump (OFF-CPB SC)...
July 28, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28729354/continuous-flow-lvad-support-causes-a-distinct-form-of-intestinal-angiodysplasia
#8
Jooeun Kang, Samson Hennessy-Strahs, Pawel Kwiatkowski, Christian Bermudez, Michael A Acker, Pavan Atluri, Patrick McConnell, Carlo R Bartoli
Rationale: The objective of this autopsy study was to determine whether abnormal gastrointestinal vascularity develops during continuous-flow LVAD support. Objective: Left ventricular assist device (LVAD) support causes pathologic degradation of von Willebrand factor (vWF) and bleeding from gastrointestinal angiodysplasia at an alarming rate. It has been speculated that LVAD support, itself may cause angiodysplasia. The relationship to abnormal vWF metabolism is unknown. We tested the hypothesis that abnormal gastrointestinal vascularity develops during continuous-flow LVAD support...
July 20, 2017: Circulation Research
https://www.readbyqxmd.com/read/28728782/novel-nonresectional-mitral-valve-repair-another-tool-in-the-mitral-surgeon-s-armamentarium
#9
EDITORIAL
Malini Daniel, Pavan Atluri
No abstract text is available yet for this article.
June 20, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28697122/the-emerging-role-of-endoscopists-in-treating-unresectable-pancreatic-cancer
#10
Adrianne Tsen, Matthew Van Norman, Sreedevi Atluri, Laura Rosenkranz
Pancreatic adenocarcinoma is the eighth leading cause of cancer deaths worldwide in men and ninth leading cause in women. Surgical resection offers the only chance of potential cure; however, only 9.4% of patients present at the localized, resectable stage, whereas the rest present at the locally advanced or metastatic, unresectable stages. Because of the guarded outcomes following systemic chemoradiation and the associated systemic toxicities, locoregional therapies have recently gained popularity. Various endoscopic techniques (endoscopic ultrasound [EUS]-guided ablative therapies, fine-needle instillation of antitumor agents, stereotactic body radiation therapy with EUS-guided fiducial marker placement, and EUS-guided brachytherapy) have been explored over the past several years...
August 2017: Pancreas
https://www.readbyqxmd.com/read/28683999/new-and-improved-implications-of-a-cardiac-support-device-composed-of-biodegradable-materials
#11
EDITORIAL
Jennifer J Chung, Rahul Kanade, Pavan Atluri
No abstract text is available yet for this article.
2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28670531/high-prevalence-of-serine-protease-inhibitor-kazal-type-1-gene-variations-detected-by-whole-gene-sequencing-in-patients-with-fibrocalculous-pancreatic-diabetes
#12
Anish Kolly, C Shivaprasad, Annie A Pulikkal, Sridevi Atluri, Vijaya Sarathi, C S Dwarakanath
AIM OF STUDY: The aim is to study the prevalence and pattern of serine protease inhibitor Kazal type 1 (SPINK1) gene variations in patients with fibrocalculous pancreatic diabetes (FCPD) using whole gene sequencing. MATERIALS AND METHODS: A total of 56 consecutive patients of FCPD were recruited for the study. Diagnosis of FCPD was based on the presence of diabetes mellitus in patients having chronic pancreatitis with radiological evidence of ductal calcifications, in the absence of other known causes for pancreatitis...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28648332/turn-up-the-pump-or-fix-the-leak
#13
EDITORIAL
Mark Helmers, Pavan Atluri
No abstract text is available yet for this article.
May 18, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28647097/type-a-dissections-in-patients-with-marfan-syndrome-when-less-is-not-more
#14
EDITORIAL
Jennifer J Chung, Jonathan Gordon, Pavan Atluri
No abstract text is available yet for this article.
May 31, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28549697/passing-needle-through-stone-a-novel-surgical-technique-for-porcelain-aorta
#15
EDITORIAL
Mark Helmers, Pavan Atluri
No abstract text is available yet for this article.
August 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28459740/engineering-the-future-one-cell-at-a-time-advancements-in-cell-based-techniques-from-novel-three-dimensional-cell-culture-to-a-bionic-kidney
#16
Jennifer J Chung, Maria F Arisi, Samir Zaman, Pavan Atluri
No abstract text is available yet for this article.
May 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28457697/extended-distance-cardiac-allograft-can-successfully-be-utilized-without-impacting-long-term-survival
#17
Ann C Gaffey, Carol W Chen, Jennifer J Chung, Jason Han, Anjali Owens, Michael A Acker, Pavan Atluri
BACKGROUND: Despite the severe shortage of donor cardiac allografts, the general belief in worse outcomes with donors from prolonged distances has resulted in many centers greatly limiting the acceptable geographic distance of acceptable donors. However, with improvements in allograft preservation, it is likely that distance may be extended without compromising graft integrity. We hypothesized that recipients of appropriately selected allografts from greater distances would have equivalent long-term survival compared with recipients from closer geographic regions...
September 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28431737/examining-the-dark-recesses-of-the-heart-technology-drives-innovation
#18
EDITORIAL
Malini Daniel, Pavan Atluri
No abstract text is available yet for this article.
July 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28374799/investigation-of-ac-magnetic-field-stimulated-nanoelectroporation-of-magneto-electric-nano-drug-carrier-inside-cns-cells
#19
Ajeet Kaushik, Roozbeh Nikkhah-Moshaie, Raju Sinha, Vinay Bhardwaj, Venkata Atluri, Rahul Dev Jayant, Adriana Yndart, Babak Kateb, Nezih Pala, Madhavan Nair
In this research, we demonstrate cell uptake of magneto-electric nanoparticles (MENPs) through nanoelectroporation (NEP) using alternating current (ac)-magnetic field stimulation. Uptake of MENPs was confirmed using focused-ion-beam assisted transmission electron microscopy (FIB-TEM) and validated by a numerical simulation model. The NEP was performed in microglial (MG) brain cells, which are highly sensitive for neuro-viral infection and were selected as target for nano-neuro-therapeutics. When the ac-magnetic field optimized (60 Oe at 1 kHz), MENPs were taken up by MG cells without affecting cell health (viability > 92%)...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28341625/non-cardiac-surgery-in-patients-with-continuous-flow-left-ventricular-assist-devices-a-single-institutional-experience
#20
Carol W Chen, Kristoffel R Dumon, Oren Shaked, Michael A Acker, Pavan Atluri, Daniel T Dempsey
With improvements in life expectancy for patients with continuous-flow left ventricular assist devices (LVADs), non-cardiac surgeons will increasingly encounter surgical problems in this population. 209 patients underwent LVAD placement between 10/1/2007 and 6/1/2015 at a single institution. Survival was compared between patients who had non-cardiac surgery (NCS) during the initial LVAD implantation hospitalization (n=36) and those who had NCS only in subsequent hospitalizations (n=33). Postoperative complication rates were examined...
June 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
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