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https://www.readbyqxmd.com/read/28063981/macrophage-activation-status-determines-the-internalization-of-mesoporous-silica-particles-of-different-sizes-exploring-the-role-of-different-pattern-recognition-receptors
#1
Audrey Gallud, Olesja Bondarenko, Neus Feliu, Natalia Kupferschmidt, Rambabu Atluri, Alfonso Garcia-Bennett, Bengt Fadeel
Mesoporous silica-based particles are promising candidates for biomedical applications. Here, we address the importance of macrophage activation status for internalization of AMS6 (approx. 200 nm in diameter) versus AMS8 (approx. 2 μm) mesoporous silica particles and the role of different phagocytosis receptors for particle uptake. To this end, FITC-conjugated silica particles were used. AMS8 were found to be non-cytotoxic both for M-CSF-stimulated (anti-inflammatory) and GM-CSF-stimulated (pro-inflammatory) macrophages, whereas AMS6 exhibited cytotoxicity towards M-CSF-stimulated, but not GM-CSF-stimulated macrophages; this toxicity was, however, mitigated in the presence of serum...
December 27, 2016: Biomaterials
https://www.readbyqxmd.com/read/28003575/higher-body-mass-index-increases-risk-of-heartmate-ii-pump-thrombosis-but-does-not-adversely-affect-long-term-survival
#2
Jason J Han, Renganaden Sooppan, Adam P Johnson, Carol W Chen, Ann C Gaffey, Emily C Phillips, Jessica Howard, J Eduardo Rame, Michael A Acker, Pavan Atluri
BACKGROUND: Obesity has been correlated with various adverse events in patients who receive left ventricular assist devices (LVAD). In this study, we sought to further characterize the role of obesity in this patient population.Methods and Results:We performed a retrospective analysis of 164 patients implanted with a HeartMate II from August 2008 to December 2014. Patients were categorized into 2 BMI groups based on WHO guidelines: BMI 18.5-30 kg/m(2)(n=99) and BMI >30 kg/m(2)(n=65)...
December 22, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27997133/injectable-guest-host-assembled-polyethylenimine-hydrogel-for-sirna-delivery
#3
Leo L Wang, Janna N Sloand, Ann C Gaffey, Chantel M Venkataraman, Zhichun Wang, Alen Trubelja, Daniel A Hammer, Pavan Atluri, Jason A Burdick
While siRNA has tremendous potential for therapeutic applications, advancement is limited by poor delivery systems. Systemically, siRNAs are rapidly degraded, may have off-target silencing, and necessitate high working concentrations. To overcome this, we developed an injectable, guest-host assembled hydrogel between polyethylenimine (PEI) and polyethylene glycol (PEG) for local siRNA delivery. Guest-host modified polymers assembled with siRNAs to form polyplexes that had improved transfection and viability compared to PEI...
December 20, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/27990501/mcrave-continuous-estimation-of-craving-during-smoking-cessation
#4
Soujanya Chatterjee, Karen Hovsepian, Hillol Sarker, Nazir Saleheen, Mustafa al'Absi, Gowtham Atluri, Emre Ertin, Cho Lam, Andrine Lemieux, Motohiro Nakajima, Bonnie Spring, David W Wetter, Santosh Kumar
Craving usually precedes a lapse for impulsive behaviors such as overeating, drinking, smoking, and drug use. Passive estimation of craving from sensor data in the natural environment can be used to assist users in coping with craving. In this paper, we take the first steps towards developing a computational model to estimate cigarette craving (during smoking abstinence) at the minute-level using mobile sensor data. We use 2,012 hours of sensor data and 1,812 craving self-reports from 61 participants in a smoking cessation study...
September 2016: Proceedings of the ACM International Conference on Ubiquitous Computing
https://www.readbyqxmd.com/read/27774054/tmseeg-a-matlab-based-graphical-user-interface-for-processing-electrophysiological-signals-during-transcranial-magnetic-stimulation
#5
Sravya Atluri, Matthew Frehlich, Ye Mei, Luis Garcia Dominguez, Nigel C Rogasch, Willy Wong, Zafiris J Daskalakis, Faranak Farzan
Concurrent recording of electroencephalography (EEG) during transcranial magnetic stimulation (TMS) is an emerging and powerful tool for studying brain health and function. Despite a growing interest in adaptation of TMS-EEG across neuroscience disciplines, its widespread utility is limited by signal processing challenges. These challenges arise due to the nature of TMS and the sensitivity of EEG to artifacts that often mask TMS-evoked potentials (TEP)s. With an increase in the complexity of data processing methods and a growing interest in multi-site data integration, analysis of TMS-EEG data requires the development of a standardized method to recover TEPs from various sources of artifacts...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27756463/off-pump-ventricular-assist-device-implantation-easy-as-1-2-3
#6
EDITORIAL
Arman Kilic, Pavan Atluri
No abstract text is available yet for this article.
January 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27726874/transdifferentiation-a-new-frontier-in-cardiovascular-cell-therapy
#7
EDITORIAL
Michael Ibrahim, Pavan Atluri
No abstract text is available yet for this article.
January 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27717422/left-ventricular-assist-device-design-reduces-von-willebrand-factor-degradation-a-comparative-study-between-the-heartmate-ii-and-the-evaheart-left-ventricular-assist-system
#8
Carlo R Bartoli, Jooeun Kang, David Zhang, Jessica Howard, Michael Acker, Pavan Atluri, Tadashi Motomura
BACKGROUND: Supraphysiologic shear stress from continuous-flow left ventricular assist devices (LVADs) accelerates von Willebrand factor (vWF) degradation and predisposes patients to nonsurgical bleeding. It is unknown whether unique design characteristics of LVADs differentially affect vWF degradation. We tested the hypothesis that the centrifugal-flow EVAHEART (Evaheart, Houston, TX) left ventricular assist system (LVAS), which was designed to minimize shear stress (low operational revolutions per minute [rpm], larger flow gaps, low shear stress, flat H-Q curve), reduced vWF degradation versus the axial-flow HeartMate II (Thoratec, Pleasanton, CA) LVAD...
October 4, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27706263/gene-activated-titanium-surfaces-promote-in-vitro-osteogenesis
#9
Keerthi Atluri, Joun Lee, Denise Seabold, Satheesh Elangovan, Aliasger K Salem
PURPOSE: Commercially pure titanium (CpTi) and its alloys possess favorable mechanical and biologic properties for use as implants in orthopedics and dentistry. However, failures in osseointegration still exist and are common in select individuals with risk factors such as smoking. Therefore, in this study, a proposal was made to enhance the potential for osseointegration of CpTi discs by coating their surfaces with nanoplexes comprising polyethylenimine (PEI) and plasmid DNA (pDNA) encoding bone morphogenetic protein-2 (pBMP-2)...
October 5, 2016: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/27621622/development-of-timp1-magnetic-nanoformulation-for-regulation-of-synaptic-plasticity-in-hiv-1-infection
#10
Venkata Subba Rao Atluri, Rahul Dev Jayant, Sudheesh Pilakka-Kanthikeel, Gabriella Garcia, Thangavel Samikkannu, Adriana Yndart, Ajeet Kaushik, Madhavan Nair
Although the introduction of antiretroviral therapy has reduced the prevalence of severe forms of neurocognitive disorders, human immunodeficiency virus (HIV)-1-associated neurocognitive disorders were observed in 50% of HIV-infected patients globally. The blood-brain barrier is known to be impermeable to most of antiretroviral drugs. Successful delivery of antiretroviral drugs into the brain may induce an inflammatory response, which may further induce neurotoxicity. Therefore, alternate options to antiretroviral drugs for decreasing the HIV infection and neurotoxicity may help in reducing neurocognitive impairments observed in HIV-infected patients...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27583217/evaluation-of-surface-detail-reproduction-dimensional-stability-and-gypsum-compatibility-of-monophase-polyvinyl-siloxane-and-polyether-elastomeric-impression-materials-under-dry-and-moist-conditions
#11
Sriharsha Babu Vadapalli, Kaleswararao Atluri, Madhu Sudhan Putcha, Sirisha Kondreddi, N Suman Kumar, Durga Prasad Tadi
OBJECTIVES: This in vitro study was designed to compare polyvinyl-siloxane (PVS) monophase and polyether (PE) monophase materials under dry and moist conditions for properties such as surface detail reproduction, dimensional stability, and gypsum compatibility. MATERIALS AND METHODS: Surface detail reproduction was evaluated using two criteria. Dimensional stability was evaluated according to American Dental Association (ADA) specification no. 19. Gypsum compatibility was assessed by two criteria...
July 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/27544289/valve-selection-in-end-stage-renal-disease-should-it-always-be-biological
#12
Matthew L Williams, Joseph E Bavaria, Michael A Acker, Nimesh D Desai, Prashanth Vallabhajosyula, W Clark Hargrove, Pavan Atluri, Wilson Y Szeto
BACKGROUND: When valve replacement is required in patients with end-stage renal disease (ESRD), it is not clear if mechanical or bioprosthetic valve selection is better. We compared outcomes between ESRD patients who underwent either mechanical or biologic valve replacements at our institution. METHODS: All patients with ESRD who underwent either mitral or aortic valve replacement from 2002 to 2014 at our institution were reviewed (n = 215; mechanical = 64, biological = 151)...
August 17, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27535703/hiv-and-cocaine-impact-glial-metabolism-energy-sensor-amp-activated-protein-kinase-role-in-mitochondrial-biogenesis-and-epigenetic-remodeling
#13
Thangavel Samikkannu, Venkata S R Atluri, Madhavan P N Nair
HIV infection and cocaine use have been identified as risk factors for triggering neuronal dysfunction. In the central nervous system (CNS), energy resource and metabolic function are regulated by astroglia. Glia is the major reservoir of HIV infection and disease progression in CNS. However, the role of cocaine in accelerating HIV associated energy deficit and its impact on neuronal dysfunction has not been elucidated yet. The aim of this study is to elucidate the molecular mechanism of HIV associated neuropathogenesis in cocaine abuse and how it accelerates the energy sensor AMPKs and its subsequent effect on mitochondrial oxidative phosphorylation (OXPHOS), BRSKs, CDC25B/C, MAP/Tau, Wee1 and epigenetics remodeling complex SWI/SNF...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27498902/left-ventricular-assist-devices-and-small-body-surface-area%C3%A3-a-clinical-concern
#14
Michael Ibrahim, Arman Kilic, Pavan Atluri
No abstract text is available yet for this article.
August 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27485679/stapled-aortic-graft-to-graft-anastomoses-is-automation-optimization
#15
EDITORIAL
Arman Kilic, Pavan Atluri
No abstract text is available yet for this article.
October 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27476028/nonfunctional-pacemaker-leads-to-remove-or-not-to-remove-that-is-the-multifactorial-question
#16
EDITORIAL
Carol W Chen, Pavan Atluri
No abstract text is available yet for this article.
October 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27469015/right-ventricular-response-to-pulsatile-load-is-associated-with-early-right-heart-failure-and-mortality-after-left-ventricular-assist-device
#17
E Wilson Grandin, Payman Zamani, Jeremy A Mazurek, Gregory S Troutman, Edo Y Birati, Esther Vorovich, Julio A Chirinos, Ryan J Tedford, Kenneth B Margulies, Pavan Atluri, J Eduardo Rame
BACKGROUND: Right ventricular (RV) adaptation to afterload is crucial for patients undergoing continuous-flow left ventricular assist device (cf-LVAD) implantation. We hypothesized that stratifying patients by RV pulsatile load, using pulmonary arterial compliance (PAC), and RV response to load, using the ratio of central venous to pulmonary capillary wedge pressure (CVP:PCWP), would identify patients at high risk for early right heart failure (RHF) and 6-month mortality after cf-LVAD...
June 24, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27465276/coupling-of-transient-near-infrared-photonic-with-magnetic-nanoparticle-for-potential-dissipation-free-biomedical-application-in-brain
#18
Vidya Sagar, V S R Atluri, A Tomitaka, P Shah, A Nagasetti, S Pilakka-Kanthikeel, N El-Hage, A McGoron, Y Takemura, M Nair
Combined treatment strategies based on magnetic nanoparticles (MNPs) with near infrared ray (NIR) biophotonic possess tremendous potential for non-invasive therapeutic approach. Nonetheless, investigations in this direction have been limited to peripheral body region and little is known about the potential biomedical application of this approach for brain. Here we report that transient NIR exposure is dissipation-free and has no adverse effect on the viability and plasticity of major brain cells in the presence or absence superparamagnetic nanoparticles...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27419908/electrochemical-monitoring-on-chip-e-moc-of-hiv-infection-in-presence-of-cocaine-and-therapeutics
#19
Ajeet Kaushik, Phani Kiran Vabbina, Venkata Atluri, Pratikkumar Shah, Arti Vashist, Rahul Dev Jayant, Adriana Yandart, Madhavan Nair
Electrochemical monitoring-on-chip (E-MoC)-based approach for rapid assessment of human immunodeficiency virus (HIV)-infection in the presence of cocaine (Coc) and specific drugs namely i.e., tenofovir (Tef), rimcazole (RA) is demonstrated here, for the first time, using electrochemical impedance spectroscopy (EIS). An in-vitro primary human astrocytes (HA) model was developed using a cultureware chip (CC, used for E-MoC) for HIV-infection, Coc exposure and treatment with anti-HIV drug i.e., Tef, and Coc antagonist i...
December 15, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27389383/ecg-of-the-month-sepsis-ards-and-tracheal-intubation
#20
D Luke Glancy, Prashanthi Atluri
A furuncle on the leg of a 23-year-old woman led to methicillin-resistant staphylococcus aureus sepsis and adult respiratory distress syndrome (ARDS) requiring tracheal intubation in the intensive care unit (ICU). Initially her electrocardiograms (ECGs) showed sinus tachycardia, but otherwise were unchanged from prior ECGs. A week into her ICU stay a different rhythm occurred.
May 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
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