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https://www.readbyqxmd.com/read/29760917/factors-associated-with-glycemic-status-and-ability-to-adapt-to-changing-demands-in-people-with-and-without-type-2-diabetes-mellitus-a-cross-sectional-study
#1
Bertha Cecilia Salazar-González, Esther C Gallegos-Cabriales, Alicia Rivera-Castillo, Arnulfo González-Cantú, Marco Vinicio Gómez-Meza, Jesús Zacarías Villarreal-Pérez
Objectives: Type 2 diabetes mellitus studies focus on metabolic indicators and different self-reported lifestyle or care behaviors. Self-reported instruments involve conscious process therefore responses might not reflect reality. Meanwhile implicit responses involve automatic, unconscious processes underlying social judgments and behavior. No studies have explored the combined influence of both metabolic indicators and implicit responses on lifestyle practices in type 2 diabetes mellitus patients...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29753114/directional-k-channel-insertion-in-a-single-phospholipid-bilayer-neutron-reflectometry-and-electrophysiology-in-the-joint-exploration-of-a-model-membrane-functional-platform
#2
V Rondelli, E Del Favero, P Brocca, G Fragneto, M Trapp, L Mauri, M G Ciampa, G Romani, C J Braun, L Winterstein, I Schroeder, G Thiel, A Moroni, L Cantu'
We investigated the insertion of small potassium (K+ ) channel proteins (KcvMA-1D and KcvNTS ) into model membranes and the lipid-protein structural interference, combining neutron reflectometry and electrophysiology. Neutron reflectometry experiments showed how the transverse structure and mechanical properties of the bilayer were modified, upon insertion of the proteins in single model-membranes, either supported on solid substrate or floating. Parallel electrophysiology experiments were performed on the same channels reconstituted in free-standing planar lipid bilayers, of both typical composition and matched to the neutron reflectometry experiment, assessing their electrical features...
May 9, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29747066/spontaneous-dna-damage-to-the-nuclear-genome-promotes-senescence-redox-imbalance-and-aging
#3
Andria R Robinson, Matthew J Yousefzadeh, Tania A Rozgaja, Jin Wang, Xuesen Li, Jeremy S Tilstra, Chelsea H Feldman, Siobhán Q Gregg, Caroline H Johnson, Erin M Skoda, Marie-Céline Frantz, Harris Bell-Temin, Hannah Pope-Varsalona, Aditi U Gurkar, Luigi A Nasto, Renã A S Robinson, Heike Fuhrmann-Stroissnigg, Jolanta Czerwinska, Sara J McGowan, Nadiezhda Cantu-Medellin, Jamie B Harris, Salony Maniar, Mark A Ross, Christy E Trussoni, Nicholas F LaRusso, Eugenia Cifuentes-Pagano, Patrick J Pagano, Barbara Tudek, Nam V Vo, Lora H Rigatti, Patricia L Opresko, Donna B Stolz, Simon C Watkins, Christin E Burd, Claudette M St Croix, Gary Siuzdak, Nathan A Yates, Paul D Robbins, Yinsheng Wang, Peter Wipf, Eric E Kelley, Laura J Niedernhofer
Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach to determine if spontaneous nuclear DNA damage is sufficient to initiate senescence in mammals. Ercc1-/∆ mice with reduced expression of ERCC1-XPF endonuclease have impaired capacity to repair the nuclear genome. Ercc1-/∆ mice accumulated spontaneous, oxidative DNA damage more rapidly than wild-type (WT) mice. As a consequence, senescent cells accumulated more rapidly in Ercc1-/∆ mice compared to repair-competent animals...
April 13, 2018: Redox Biology
https://www.readbyqxmd.com/read/29741914/barriers-to-breastfeeding-in-female-physicians
#4
Rebecca M Cantu, Marie S Gowen, Xinyu Tang, Kristin Mitchell
BACKGROUND: Breast milk is considered the normative nutrition for human infants, and exclusive breastfeeding for the first 6 months of life is recommended by several national and global societies. Female physicians are a high-risk group for early unintended weaning. We aimed to assess and compare the most common barriers to successful breastfeeding perceived by female physicians in various stages of training and practice. MATERIALS AND METHODS: Female faculty physicians and trainees (medical students, resident physicians, and fellows) affiliated with a large medical university in 2016 were surveyed via an anonymous web-based survey distributed through institutional e-mail lists...
May 9, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29737834/ph-controlled-liposomes-for-enhanced-cell-penetration-in-tumor-environment
#5
Michela Barattin, Andrea Mattarei, Anna Balasso, Cristina Paradisi, Laura Cantù, Elena Del Favero, Tapani Viitala, Francesca Mastrotto, Paolo Caliceti, Stefano Salmaso
An innovative pH-switchable colloidal system that can be exploited for site-selective anticancer drug delivery has been generated by liposomes decoration with a new novel synthetic non-peptidic oligo-Arginine cell-penetration enhancer (CPE) and a quenching PEGylated counterpart that detaches from the vesicle surface under the acidic conditions of tumors. The CPE module (Arg4-DAG) is formed by four arginine units conjugated to a first generation (G1) 2,2-bis(hydroxymethyl)propionic acid (bis-MPA)/2,2-bis(aminomethyl)propionic acid (bis-AMPA) polyester dendron terminating with 1,2-distearoyl-3-azidopropane for liposome bilayer insertion...
May 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29735086/understanding-microoxygenation-effect-of-viable-yeasts-and-sulfur-dioxide-levels-on-the-sensory-properties-of-a-merlot-red-wine
#6
María-Pilar Sáenz-Navajas, Charlie Henschen, Annegret Cantu, Aude A Watrelot, Andrew L Waterhouse
No abstract text is available yet for this article.
June 2018: Food Research International
https://www.readbyqxmd.com/read/29732727/cytomorphology-of-epithelioid-gastrointestinal-stromal-tumor
#7
Miguel Dario Cantu, Abha Goyal
No abstract text is available yet for this article.
May 6, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29727140/a-retrospective-study-on-sperm-banking-a-uruguayan-experience
#8
Rosina Ordoqui, Natalibeth Barrera, José María Montes, Mariel Canepa, Carla Bonelli, Carolina Surka, Andrea Torrens, Lidia Cantú, Stefan S du Plessis
OBJECTIVE: The purpose of this study was to investigate the status of homologous sperm banking in Uruguay. METHODS: A retrospective investigation was performed on data collected between 2013 and 2015. Reasons for sperm banking, patient age, pre-freeze and post-thaw semen parameters, and recovery rates were analyzed. RESULTS: 623 samples were cryobanked between 2013 and 2015. Only 324 samples were considered for analysis after selection based on inclusion criteria...
May 4, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29717643/the-national-institute-of-neurological-disorders-and-stroke-and-department-of-defense-sport-related-concussion-common-data-elements-version-1-0-recommendations
#9
Steven P Broglio, Anthony P Kontos, Harvey Levin, Kathryn Schneider, Elisabeth A Wilde, Robert C Cantu, Nina Feddermann-Demont, Gordon Fuller, Isabelle Gagnon, Gerry Gioia, Christopher C Giza, Grace Sophia Griesbach, John J Leddy, Michael L Lipton, Andrew Mayer, Thomas McAllister, Michael McCrea, Lara McKenzie, Margot Putukian, Stefano Signoretti, Stacy J Suskauer, Robert Tamburro, Michael Turner, Keith Owen Yeates, Roger Zemek, Sherita Ala'i, Joy Esterlitz, Katelyn Gay, Patrick S F Bellgowan, Kristen Joseph
AIM: Through a partnership with the National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), and Department of Defense (DoD), the development of Sport-Related Concussion (SRC) Common Data Elements (CDEs) was initiated. The aim of this collaboration was to increase the efficiency and effectiveness of clinical research studies and clinical treatment outcomes, increase data quality, facilitate data sharing across studies, reduce study start-up time, more effectively aggregate information into metadata results, and educate new clinical investigators...
May 2, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29710395/age-of-first-exposure-to-tackle-football-and-chronic-traumatic-encephalopathy
#10
Michael L Alosco, Jesse Mez, Yorghos Tripodis, Patrick T Kiernan, Bobak Abdolmohammadi, Lauren Murphy, Neil W Kowall, Thor D Stein, Bertrand Russell Huber, Lee E Goldstein, Robert C Cantu, Douglas I Katz, Christine E Chaisson, Brett Martin, Todd M Solomon, Michael D McClean, Daniel H Daneshvar, Christopher J Nowinski, Robert A Stern, Ann C McKee
OBJECTIVE: To examine the effect of age of first exposure to tackle football on CTE pathological severity and age of neurobehavioral symptom onset in tackle football players with neuropathologically-confirmed CTE. METHODS: The sample included 246 tackle football players who donated their brains for neuropathological examination. 211 were diagnosed with CTE (126/211 were without comorbid neurodegenerative diseases) and 35 were without CTE. Informant interviews ascertained age of first exposure and age of cognitive and behavioral/mood symptom onset...
April 30, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29701996/an-alternative-approach-for-the-analysis-of-time-to-event-and-survival-outcomes-in-pulmonary-medicine
#11
Michael O Harhay, Raphaël Porcher, Edward Cantu, Michael J Crowther, Jason D Christie, Gabriel Thabut, Gavin C Donaldson
No abstract text is available yet for this article.
April 27, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29682202/ctcf-kdm4a-complex-correlates-with-histone-modifications-that-negatively-regulate-chd5-gene-expression-in-cancer-cell-lines
#12
Lissania Guerra-Calderas, Rodrigo González-Barrios, Carlos César Patiño, Nicolás Alcaraz, Marisol Salgado-Albarrán, David Cantú de León, Clementina Castro Hernández, Yesennia Sánchez-Pérez, Héctor Aquiles Maldonado-Martínez, Inti A De la Rosa-Velazquez, Fernanda Vargas-Romero, Luis A Herrera, Alejandro García-Carrancá, Ernesto Soto-Reyes
Histone demethylase KDM4A is involved in H3K9me3 and H3K36me3 demethylation, which are epigenetic modifications associated with gene silencing and RNA Polymerase II elongation, respectively. KDM4A is abnormally expressed in cancer, affecting the expression of multiple targets, such as the CHD5 gene. This enzyme localizes at the first intron of CHD5 , and the dissociation of KDM4A increases gene expression. In vitro assays showed that KDM4A-mediated demethylation is enhanced in the presence of CTCF, suggesting that CTCF could increase its enzymatic activity in vivo, however the specific mechanism by which CTCF and KDM4A might be involved in the CHD5 gene repression is poorly understood...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29670570/mexican-national-institute-of-neurology-and-neurosurgery-stroke-registry-results-of-a-25-year-hospital-based-study
#13
Antonio Arauz, Juan Manuel Marquez-Romero, Miguel A Barboza, Fabiola Serrano, Carol Artigas, Luis Manuel Murillo-Bonilla, Carlos Cantú-Brito, José Luis Ruiz-Sandoval, Fernando Barinagarrementeria
Background and purpose: Stroke has been scarcely studied in Latin America (LA). The Mexican Institute of Neurology Stroke Registry was established in 1990 as a prospective computer-based database to register data obtained from patients admitted with stroke. Using this data, we attempted to define the profile of risk factors and outcomes. Methods: The demographic data, stroke description, ancillary tests, vascular risk factors, and modified Rankin scale (mRs) were registered...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29667786/frailty-phenotypes-and-mortality-after-lung-transplantation-a-prospective-cohort-study
#14
Jonathan P Singer, Joshua M Diamond, Michaela R Anderson, Patricia P Katz, Ken Covinsky, Michelle Oyster, Tatiana Blue, Allison Soong, Laurel Kalman, Pavan Shrestha, Selim M Arcasoy, John R Greenland, Lori Shah, Jasleen Kukreja, Nancy P Blumenthal, Imaani Easthausen, Jeffrey A Golden, Amika McBurnie, Ed Cantu, Joshua Sonett, Steven Hays, Hilary Robbins, Kashif Raza, Matthew Bacchetta, Rupal J Shah, Frank D'Ovidio, Aida Venado, Jason D Christie, David J Lederer
Frailty is associated with increased mortality among lung transplant candidates. We sought to determine the association between frailty, as measured by the Short Physical Performance Battery (SPPB), and mortality after lung transplantation. In a multicenter prospective cohort study of adults who underwent lung transplantation, preoperative frailty was assessed with the SPPB (n = 318) and, in a secondary analysis, the Fried Frailty Phenotype (FFP; n = 299). We tested the association between preoperative frailty and mortality following lung transplantation with propensity score-adjusted Cox models...
April 18, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29662191/wnt-ligands-control-initiation-and-progression-of-human-papillomavirus-driven-squamous-cell-carcinoma
#15
Dario Zimmerli, Virginia Cecconi, Tomas Valenta, George Hausmann, Claudio Cantù, Gaetana Restivo, Jürg Hafner, Konrad Basler, Maries van den Broek
Human papillomavirus (HPV)-driven cutaneous squamous cell carcinoma (cSCC) is the most common cancer in immunosuppressed patients. Despite indications suggesting that HPV promotes genomic instability during cSCC development, the molecular pathways underpinning HPV-driven cSCC development remain unknown. We compared the transcriptome of HPV-driven mouse cSCC with normal skin and observed higher amounts of transcripts for Porcupine and WNT ligands in cSCC, suggesting a role for WNT signaling in cSCC progression...
April 17, 2018: Oncogene
https://www.readbyqxmd.com/read/29658945/experience-with-ok-432-in-lymphatic-vascular-malformations-in-a-hospital-from-northern-mexico
#16
Jorge Alberto Cantú Reyes, Erik Antonio Mier Escurra, Joel Cázares Rangel, Julieta Rodríguez De Ita, Jan Lammel Lindemann, Luis Francisco Rendón García, Boris José Chacón López
Background: Lymphatic vascular malformations (LVM) or formerly called lymphangiomas are congenital malformations present in about 1 out of 6000 to -16000 births. The most relevant classification system for lymphangioma management is based on the size of the cysts. Spontaneous resolution is uncommon; thus, expectant management is not recommended. The classic treatment is excisional surgery, but it can affect adjacent structures or have relapses, so, sclerosing substances like OK-432 are being studied...
2018: Boletín Médico del Hospital Infantil de México
https://www.readbyqxmd.com/read/29621320/medication-and-trial-duration-influence-postural-and-pointing-parameters-during-a-standing-repetitive-pointing-task-in-individuals-with-parkinson-s-disease
#17
Deborah A Jehu, Hiram Cantù, Allen Hill, Caroline Paquette, Julie N Côté, Julie Nantel
We aimed to determine the effects of levodopa medication on the performance of a repetitive pointing task while standing, and to investigate the optimal trial duration in individuals with Parkinson's disease, and older adults. Seventeen individuals with Parkinson's disease (5 freezers) and 9 older adults stood on force platforms for 30 s and 120 s while performing a bilateral repetitive pointing task, tracked by motion capture. Participants with Parkinson's disease were assessed on and off medication and older adults were also assessed on separate days...
2018: PloS One
https://www.readbyqxmd.com/read/29615845/novel-mutation-in-abbc9-gene-associated-with-congenital-hypertrichosis-and-acromegaloid-facial-features-without-cardiac-or-skeletal-anomalies-a-new-phenotype
#18
Harry Pachajoa, William López-Quintero, Sara Vanegas, Claudia L Montoya, Diana Ramírez-Montaño
Introduction: Mutations in ABCC9 are associated with Cantú syndrome (CS), a very rare genetic disorder characterized by congenital hypertrichosis, acromegaloid facial appearance (AFA), cardiomegaly, and skeletal anomalies. Case report: We report an 8-year-old female patient with congenital generalized hypertrichosis and coarse facial appearance but without cardiovascular or skeletal compromise. Whole exome sequencing revealed a novel de novo heterozygous mutation in ABCC9 ...
2018: Application of Clinical Genetics
https://www.readbyqxmd.com/read/29601224/physical-therapists-perception-of-workplace-ethics-in-an-evolving-health-care-delivery-environment-a-cross-sectional-survey
#19
Roberto Cantu
Physical therapists are trained and obligated to deliver optimal health care and put patients first above all else. In the changing health-care environment, health-care organizations are grappling with controlling cost and increasing revenues. Moral distress may be created when physical therapists' desire to provide optimal care conflicts with their organization's goals to remain financially viable or profitable. Moral distress has been associated with low perception of ethical environment, professional burnout, and high turnover in organizations...
March 30, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29595750/cant%C3%A3%C2%BA-syndrome-the-changing-phenotype-a-report-of-the-two-oldest-dutch-patients
#20
Helen I Roessler, Catharina M L Volker-Touw, Paulien A Terhal, Gijs van Haaften, Mieke M van Haelst
No abstract text is available yet for this article.
March 27, 2018: Clinical Dysmorphology
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