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https://www.readbyqxmd.com/read/29346256/causes-preventability-and-cost-of-unplanned-rehospitalizations-within-30-days-of-discharge-following-lung-transplantation
#1
Andrew M Courtwright, Derek Zaleski, Lisa Gardo, Vivek N Ahya, Jason D Christie, Maria Crespo, Denis Hadjiliadis, James Lee, Maria Molina, Namrata Patel, Mary Porteous, Edward E Cantu, Christian Bermudez, Joshua M Diamond
BACKGROUND: Unplanned rehospitalizations (UR) within 30 days of discharge are common following lung transplantation. It is unknown whether UR represent preventable gaps in care or necessary interventions for complex patients. The objective of this study was to assess the incidence, causes, risk factors, and preventability of UR following initial discharge after lung transplantation. METHODS: This was a single-center prospective cohort study. Subjects completed a modified Short Physical Performance Battery (SPPB) to assess frailty at listing and at initial hospital discharge after transplantation and the State-Trait Anxiety Inventory (STAI) at discharge...
January 18, 2018: Transplantation
https://www.readbyqxmd.com/read/29331960/pregnancy-loss-and-carotid-intima-media-thickness-in-mexican-women
#2
Sandra A Hartasanchez, Mario Flores-Torres, Adriana Monge, Elsa Yunes, Beatriz Rodriguez, Carlos Cantu-Brito, Daniela Colaci, Hector Lamadrid-Figueroa, Ruy Lopez-Ridaura, Martin Lajous
BACKGROUND: Cardiovascular disease in women often develops without conventional risk factors. Prenatal loss is a common pregnancy outcome that may result in physiological changes can increase the potential future risk of cardiovascular disease. Insufficient information exists regarding the impact of pregnancy loss on early markers of cardiovascular disease risk. METHODS AND RESULTS: Cross-sectional analysis of 1767 disease-free women from the MTC (Mexican Teachers' Cohort) who had been pregnant was used to evaluate the relationship between pregnancy loss and carotid intima-media thickness (IMT)...
January 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29331861/synthesis-of-colloidal-silver-nanoparticle-clusters-and-their-application-in-ascorbic-acid-detection-by-sers
#3
Jorge L Cholula-Díaz, Diana Lomelí-Marroquín, Bidhan Pramanick, Alfonso Nieto-Argüello, Luis A Cantú-Castillo, Hyundoo Hwang
Ascorbic acid (vitamin C) has an essential role in the human body mainly due to its antioxidant function. In this work, metallic silver nanoparticle (AgNP) colloids were used in SERS experiments to detect ascorbic acid in aqueous solution. The AgNPs were synthesized by a green method using potato starch as reducing and stabilizing agent, and water as the solvent. The optical properties of the yellowish as-synthesized silver colloids were characterized by UV-vis spectroscopy, in which besides a typical band at 410 nm related to the localized surface plasmon resonance of the silver nanoparticles, a shoulder band around 500 nm, due to silver nanoparticle cluster formation, is presented when relatively higher concentrations of starch are used in the synthesis...
December 29, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29327300/cant%C3%A3%C2%BA-syndrome-with-coexisting-familial-pituitary-adenoma
#4
Pedro Marques, Rupert Spencer, Patrick J Morrison, Ian M Carr, Mary N Dang, David T Bonthron, Steven Hunter, Márta Korbonits
CONTEXT: Pseudoacromegaly describes conditions with an acromegaly related physical appearance without abnormalities in the growth hormone (GH) axis. Acromegaloid facies, together with hypertrichosis, are typical manifestations of Cantú syndrome. CASE DESCRIPTION: We present a three-generation family with 5 affected members, with marked acromegaloid facies and prominent hypertrichosis, due to a novel missense variant in the ABCC9 gene. The proband, a 2-year-old girl, was referred due to marked hypertrichosis, noticed soon after birth, associated with coarsening of her facial appearance...
January 11, 2018: Endocrine
https://www.readbyqxmd.com/read/29322768/identification-of-novel-inks-for-3d-printing-using-high-throughput-screening-bioresorbable-photocurable-polymers-for-controlled-drug-delivery
#5
Iria Louzao, Britta Koch, Vincenzo Taresco, Laura Ruiz Cantu, Derek J Irvine, Clive J Roberts, Christopher J Tuck, Cameron Alexander, Richard J M Hague, Ricky D Wildman, Morgan Russell Alexander
A robust discovery methodology is presented to identify novel biomaterials suitable for 3D printing. Currently the application of Additive Manufacturing is limited by the availability of functional inks, especially in the area of biomaterials-this method tackles this problem for the first time allowing hundreds of formulations to be readily assessed. Several functional properties, including the release of an antidepressive drug (paroxetine), cytotoxicity and printability are screened for 253 new ink formulations in a high-throughput format as well as mechanical properties...
January 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29313600/dna-damage-in-acute-myeloid-leukemia-patients-of-northern-mexico
#6
Martha I Dávila-Rodríguez, Elva I Cortés-Gutiérrez, Roberto Hernández-Valdés, Karla Guzmán-Cortés, Rosa E De León-Cantú, Ricardo M Cerda-Flores, Enrique Báez-De la Fuente
The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage detected in patients with newly diagnosed AML was similar to that observed for the controls; this might be explained by the stimulation of a repair pathway by the pathogenesis itself. These findings indicate that inhibiting the repair pathway could be proposed to enhance the efficacy of chemotherapy...
December 11, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29275331/cantu-syndrome-associated-sur2-abcc9-mutations-in-distinct-structural-domains-result-in-katp-channel-gain-of-function-by-differential-mechanisms
#7
Conor McClenaghan, Alex Hanson, Monica Sala-Rabanal, Helen I Roessler, Dragana Josifova, Dorothy K Grange, Gijs van Haaften, Colin G Nichols
The complex cardiovascular disorder Cantu syndrome (CS) arises from gain-of-function mutations in either KCNJ8 or ABCC9, the genes encoding the Kir6.1 and SUR2 subunits of ATP-sensitive potassium (KATP) channels, respectively. Recent reports indicate that such mutations can increase channel activity by multiple molecular mechanisms. In this study, we determined the mechanism by which KATP function is altered by several substitutions in distinct structural domains of SUR2: D207E in the intracellular L0-linker and Y985S, G989E, M1060I, and R1154Q/W in TMD2...
December 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29246718/lower-extremity-arterial-calcification-on-preoperative-knee-radiographs-as-a-predictor-of-postoperative-cardiovascular-events-after-primary-total-knee-arthroplasty
#8
David Cantu Morales, Justin de Beer, Danielle Petruccelli, Conrad Kabali, Mitch Winemaker
BACKGROUND: A cross-sectional study of total knee arthroplasty (TKA) patients was conducted to determine the association of lower-extremity arterial calcification (LEAC) with acute perioperative cardiovascular events (CVEs). METHODS: Regression modeling was used to examine the association of radiographic presence of LEAC and acute myocardial infarction (MI), perioperative CVE, 30-day CVE readmit, and 30-day and 1-year mortality. RESULTS: Of 900 TKA patients, LEAC was identified in 21...
November 29, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29245891/linking-dental-pathologies-and-cancer-via-wnt-signalling
#9
EDITORIAL
Pierfrancesco Pagella, Claudio Cantù, Thimios A Mitsiadis
No abstract text is available yet for this article.
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29241970/identification-of-a-folate-receptor-targeted-near-infrared-molecular-contrast-agent-to-localize-pulmonary-adenocarcinomas
#10
Jarrod D Predina, Andrew D Newton, Courtney Connolly, Ashley Dunbar, Michael Baldassari, Charuhas Deshpande, Edward Cantu, Jason Stadanlick, Sumith A Kularatne, Philip S Low, Sunil Singhal
Non-small cell lung cancer (NSCLC) is the number one cancer killer in the United States. Despite attempted curative surgical resection, nearly 40% of patients succumb to recurrent disease. High recurrence rates may be partially explained by data suggesting that 20% of NSCLC patients harbor synchronous disease that is missed during resection. In this report, we describe the use of a novel folate receptor-targeted near-infrared contrast agent (OTL38) to improve the intraoperative localization of NSCLC during pulmonary resection...
October 26, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29235415/decisional-control-preferences-among-patients-with-advanced-cancer-an-international-multicenter-cross-sectional-survey
#11
Sriram Yennurajalingam, Luis Fernando Rodrigues, Omar M Shamieh, Colombe Tricou, Marilène Filbet, Kyaw Naing, Akhileshwaran Ramaswamy, Pedro Emilio Perez-Cruz, Mary Jocylyn S Bautista, Sofia Bunge, Mary Ann Muckaden, Sarah Fakrooden, Vikash Sewram, Antonio Noguera Tejedor, Shobha S Rao, Janet L Williams, Diane D Liu, Minjeong Park, Zhanni Lu, Hilda Cantu, David Hui, Suresh K Reddy, Eduardo Bruera
BACKGROUND: Understanding patients' decision control preferences is important in providing quality cancer care. Patients' decisional control preference can be either active (patients prefer to make decisions themselves), shared (collaborative between patient, their physician, and/or family), or passive (patients prefer that the decisions are made by either the physician and/or their family). AIM: To determine the frequency and predictors of passive decision control preferences among advanced cancer patients...
December 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29229172/self-management-and-health-care-transition-among-adolescents-and-young-adults-with-chronic-kidney-disease-medical-and-psychosocial-considerations
#12
REVIEW
Maria E Díaz-González de Ferris, Marta Del Villar-Vilchis, Ricardo Guerrero, Victor M Barajas-Valencia, Emily B Vander-Schaaf, Alexandre de Pomposo, Mara Medeiros, Eniko Rak, Guillermo Cantu-Quintanilla, Rupesh Raina, Ana C Alvarez-Elias
Health care transition (HCT) is a process that requires preparation as a continuum from pediatric- to adult-focused services. For adolescents and young adults with chronic or ESRD, this process can be prolonged due to their physical, psychological, family, or ecological factors. HCT preparation is a matter of patient safety and patient rights as the consequences of poor preparation at the time of transfer to adult-focused services are great, including rejection of organs, disease relapse, or even death. We present a case to illustrate important points of HCT preparation, with suggestions for intervention by the interdisciplinary team members who serve (and will serve) these survivors of pediatric-onset health conditions...
November 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29229162/-erratum-of-optimizing-post-operative-pain-management-in-latin-america
#13
João Batista Santos Garcia, Patricia Bonilla, Durval Campos Kraychete, Fernando Cantú Flores, Elizabeth Diaz Perez de Valtolina, Carlos Guerrero
No abstract text is available yet for this article.
January 2018: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/29226140/prevalence-of-helicobacter-pylori-vaca-genotypes-and-caga-gene-in-dental-plaque-of-asymptomatic-mexican-children
#14
Alejandra Mendoza-Cantú, Víctor Hugo Urrutia-Baca, Cynthia Sofía Urbina-Ríos, Myriam Angélica De la Garza-Ramos, Martha Elena García-Martínez, Hilda H H Torre-Martínez
The variability in Helicobacter pylori vacA and cagA genes has been related to the progression of the gastrointestinal disease; also the presence of H. pylori in the oral cavity has been associated with periodontal disease in adults, but, in children without dyspeptic symptoms, little is known about this. We evaluated the prevalence of H. pylori and the presence of vacA/cagA genotypes in the oral cavity of Mexican children without dyspeptic symptoms. The gingival status was measured, and dental plaque samples (n = 100) were taken...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29222914/fibrolamellar-carcinoma-in-the-carney-complex-prkar1a-loss-instead-of-the-classic-dnajb1-prkaca-fusion
#15
P Graham Rondell, Karoline Lackner, Luigi Terracciano, Yessica González-Cantú, Joseph J Maleszewski, Patricia T Greipp, Sanford M Simon, Michael S Torbenson
Fibrolamellar carcinomas are characterized by activation of protein kinase A, a kinase composed of catalytic and regulatory subunits. PRKACA encodes a catalytic subunit of protein kinase A and almost all fibrolamellar carcinomas have a heterozygous 400kb deletion that leads to the fusion of DNAJB1 and PRKACA. The resulting DNAJB1-PRKACA fusion transcript is believed to activate protein kinase A by dysregulation of the catalytic portion of the protein. In contrast, PRKAR1A encodes one of the regulatory subunits of protein kinase A...
December 9, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29221319/lung-transplantation-in-elderly-patients
#16
REVIEW
Andrew Courtwright, Edward Cantu
Consensus statements on the selection of lung transplant candidates have consistently identified older age as a relative contraindication to transplantation. A combination of population-level demographic changes, revision of the lung allocation score (LAS), and clearer data on outcomes in elderly transplant recipients has, however, driven a steady increase in the threshold at which age is taken into consideration. This article reviews the current state of lung transplantation in elderly patients with an emphasis on the factors that have increased lung transplantation in older age groups, their expected outcomes including survival and health-related quality of life, and the factors that go in to appropriate candidate and procedure selection in this population...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29209231/early-determination-of-the-periodontal-domain-by-the-wnt-antagonist-frzb-sfrp3
#17
Thimios A Mitsiadis, Pierfrancesco Pagella, Claudio Cantù
Odontogenesis results from the continuous and reciprocal interaction between cells of the oral epithelium and cranial neural crest-derived mesenchyme. The canonical Wnt signaling pathway plays a fundamental role in mediating these interactions from the earliest stages of tooth development. Here we analyze by in situ hybridization the expression patterns of the extracellular Wnt antagonist Frzb/Sfrp3. Although Frzb is expressed in dental mesenchymal cells from the earliest stages of odontogenesis, its expression is absent from a tiny population of mesenchymal cells immediately adjacent to the invaginating dental epithelium...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29201991/white-matter-signal-abnormalities-in-former-national-football-league-players
#18
Michael L Alosco, Inga K Koerte, Yorghos Tripodis, Megan Mariani, Alicia S Chua, Johnny Jarnagin, Yashar Rahimpour, Christian Puzo, Rose C Healy, Brett Martin, Christine E Chaisson, Robert C Cantu, Rhoda Au, Michael McClean, Ann C McKee, Alexander P Lin, Martha E Shenton, Ronald J Killiany, Robert A Stern
Introduction: Later-life brain alterations in former tackle football players are poorly understood, particularly regarding their relationship with repetitive head impacts (RHIs) and clinical function. We examined white matter signal abnormalities (WMSAs) and their association with RHIs and clinical function in former National Football League (NFL) players. Methods: Eighty-six clinically symptomatic former NFL players and 23 same-age reportedly asymptomatic controls without head trauma exposure underwent magnetic resonance imaging and neuropsychological testing...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29191316/tissue-distribution-of-perfluoroalkyl-acids-and-health-status-in-wild-mozambique-tilapia-oreochromis-mossambicus-from-loskop-dam-mpumalanga-south-africa
#19
Jacqueline T Bangma, Jessica L Reiner, Hannes Botha, Theresa M Cantu, Marco A Gouws, Matthew P Guillette, Jeremy P Koelmel, Wilmien J Luus-Powell, Jan Myburgh, Olivia Rynders, Joseph R Sara, Willem J Smit, John A Bowden
This study examined concentrations of 15 perfluoroalkyl acids (PFAAs) in tissues from male Mozambique tilapia (Oreochromis mossambicus) collected at Loskop Dam, Mpumalanga, South Africa in 2014 and 2016. Nine of the 15 PFAAs were detected frequently and were included in statistical analysis and included two of the most commonly known PFAAs, perfluorooctanesulfonic acid (PFOS) (median, 41.6ng/g) and perfluorooctanoic acid (PFOA) (median, 0.0825ng/g). Of the tissues measured, plasma (2016 and 2014 median, 22...
November 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29190870/-recommendations-for-the-use-of-ranibizumab-in-diabetic-macular-edema-at-imss
#20
Roberto Ortiz-Lerma, Carlos Pedro González-Cervantes, Fabiola HernándezNúñez, Irene Ancona-Durán, Rodolfo Gregorio Barragán-Hervella, Gerardo López-Cázares, Isaac Betesh-Rodríguez, Noé Méndez, Daniel Garza-Cantú, Óscar López-Martínez, Adriana Marcela Martínez-Ruiz, Luis Miguel López-Montero, Armando Muñoz, Jorge Alberto Blancas-Ontiveros, Carlos Mariano Fernández-Trejo, Juan Carlos Mayorga-Rubalcava, Silvia Elizabeth Flores-Góngora, Jorge Luis Gómez-Galván, Patricia Armida Domínguez-Álvarez, Erik Sánchez-Hernández, Homero Cantú-Yeverinon
Diabetic macular edema can occur at any stage of diabetic retinopathy. It represents the main cause of vision loss in diabetes type I and II with a prevalence of 3-10% in diabetic patients of the Instituto Mexicano del Seguro Social (IMSS). Our aim is to elaborate treatment guidelines and provide recommendations for the use of intravitreal ranibizumab for diabetic medical edema at IMSS. Nine retina specialists and 10 ophthalmologists from IMSS high specialty medical units gathered to discuss the bibliographic evidence for the safety and efficacy of ranibizumab for this disease, in order to create consensus on its use in the institution...
November 2017: Revista Médica del Instituto Mexicano del Seguro Social
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