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https://www.readbyqxmd.com/read/28174279/a-cytoplasmic-role-of-wnt-%C3%AE-catenin-transcriptional-cofactors-bcl9-bcl9l-and-pygopus-in-tooth-enamel-formation
#1
Claudio Cantù, Pierfrancesco Pagella, Tania D Shajiei, Dario Zimmerli, Tomas Valenta, George Hausmann, Konrad Basler, Thimios A Mitsiadis
Wnt-stimulated β-catenin transcriptional regulation is necessary for the development of most organs, including teeth. Bcl9 and Bcl9l are tissue-specific transcriptional cofactors that cooperate with β-catenin. In the nucleus, Bcl9 and Bcl9l simultaneously bind β-catenin and the transcriptional activator Pygo2 to promote the transcription of a subset of Wnt target genes. We showed that Bcl9 and Bcl9l function in the cytoplasm during tooth enamel formation in a manner that is independent of Wnt-stimulated β-catenin-dependent transcription...
February 7, 2017: Science Signaling
https://www.readbyqxmd.com/read/28167493/smad4-regulates-growth-plate-matrix-production-and-chondrocyte-polarity
#2
Amanda T Whitaker, Ellora Berthet, Andrea Cantu, Diana J Laird, Tamara Alliston
Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints. The TGFβ pathway also plays a critical role in the development, organization and proliferation of the growth plate, although the exact mechanisms remain unclear. Skeletal phenotypes in Myhre syndrome overlap with processes regulated by the TGFβ pathway, including organization and proliferation of the growth plate and polarity of the chondrocyte...
February 6, 2017: Biology Open
https://www.readbyqxmd.com/read/28156645/perception-of-helpfulness-of-a-question-prompt-sheet-among-cancer-patients-attending-outpatient-palliative-care
#3
Sriram Yennu, Kresnier Perez Zapata, Hilda Cantu, Diane D Liu, Jimin Wu, Eduardo Bruera
: 25 Background: Data on the use of question prompt sheets (QPS) in palliative care is limited. Our team previously developed a single page QPS using a Delphi process. The main objective of this study was to determine the perception of helpfulness of a QPS in patient-physician communication among advanced cancer outpatients. METHODS: 104 eligible patients received the QPS for use during their first palliative care clinic. Patient and physician perceptions about the QPS were assessed at the end of the visit...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156531/spirituality-religiosity-spiritual-pain-and-quality-of-life-among-caregivers-of-latin-american-patients-with-advanced-cancer-a-multicenter-study
#4
Alejandra Palma, Eva Rossina Duarte, Monica Grez, Laura Tupper, Diane D Liu, Andrea Octavia Ferguson, Hilda Cantu, Jewel Ochoa, Janet L Williams, Eduardo Bruera
: 245 Background: Caregivers of cancer patients often face physical, and psychosocial hardship. The association between spirituality (S), religiosity (R), spiritual pain (SP), coping, and quality of life (QOL) have not been well characterized. The main purpose of this multicenter study was to determine these associations among LACs. METHODS: We interviewed 319 LACs at palliative care clinics in Chile, Guatemala, and the US. LACs completed FICA (S/R assessment), ESAS-FS, PSWQ (worry), B-COPE/B-R-COPE (coping), and FACIT-Sp (spiritual well-being)...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28144143/conductive-polymer-based-nanoparticles-for-laser-mediated-photothermal-ablation-of-cancer-synthesis-characterization-and-in-vitro-evaluation
#5
Travis Cantu, Kyle Walsh, Varun P Pattani, Austin J Moy, James W Tunnell, Jennifer A Irvin, Tania Betancourt
Laser-mediated photothermal ablation of cancer cells aided by photothermal agents is a promising strategy for localized, externally controlled cancer treatment. We report the synthesis, characterization, and in vitro evaluation of conductive polymeric nanoparticles (CPNPs) of poly(diethyl-4,4'-{[2,5-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-1,4-phenylene] bis(oxy)}dibutanoate) (P1) and poly(3,4-ethylenedioxythiophene) (PEDOT) stabilized with 4-dodecylbenzenesulfonic acid and poly(4-styrenesulfonic acid-co-maleic acid) as photothermal ablation agents...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28121422/structural-rearrangement-of-au-pd-nanoparticles-under-reaction-conditions-an-ab-initio-molecular-dynamics-study
#6
Cong-Qiao Xu, Mal-Soon Lee, Yang-Gang Wang, David C Cantu, Jun Li, Vassiliki-Alexandra Glezakou, Roger Rousseau
The structure, composition, and atomic distribution of nanoalloys under operating conditions are of significant importance for their catalytic activity. In the present work, we use ab initio molecular dynamics simulations to understand the structural behavior of Au-Pd nanoalloys supported on rutile TiO2 under different conditions. We find that the Au-Pd structure is strongly dependent on the redox properties of the support, originating from strong metal-support interactions. Under reducing conditions, Pd atoms are inclined to move toward the metal/oxide interface, as indicated by a significant increase of Pd-Ti bonds...
January 31, 2017: ACS Nano
https://www.readbyqxmd.com/read/28117940/peripheral-blood-gene-expression-changes-associated-with-primary-graft-dysfunction-after-lung-transplantation
#7
J M Diamond, E Cantu, M K Porteous, Y Suzuki, K C Meyer, D J Lederer, R K Milewski, S Arcasoy, F D'Ovidio, M Bacchetta, J R Sonett, G Singh, J Costa, J W Tobias, H Rodriguez, V M Van Deerlin, K M Olthoff, A Shaked, B-L Chang, J D Christie
Recipient responses to primary graft dysfunction (PGD) after lung transplantation may have important implications to the fate of the allograft. We therefore evaluated longitudinal differences in peripheral blood gene expression in subjects with PGD. RNA expression was measured throughout the first transplant year in 106 subjects enrolled in the Clinical Trials in Organ Transplantation-03 study using a panel of 100 hypothesis-driven genes. PGD was defined as grade 3 in the first 72 posttransplant hours. Eighteen genes were differentially expressed over the first year based on PGD development, with significant representation from innate and adaptive immunity genes, with most differences identified very early after transplant...
January 24, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28117443/symmetry-protected-collisions-between-strongly-interacting-photons
#8
Jeff D Thompson, Travis L Nicholson, Qi-Yu Liang, Sergio H Cantu, Aditya V Venkatramani, Soonwon Choi, Ilya A Fedorov, Daniel Viscor, Thomas Pohl, Mikhail D Lukin, Vladan Vuletić
Realizing robust quantum phenomena in strongly interacting systems is one of the central challenges in modern physical science. Approaches ranging from topological protection to quantum error correction are currently being explored across many different experimental platforms, including electrons in condensed-matter systems, trapped atoms and photons. Although photon-photon interactions are typically negligible in conventional optical media, strong interactions between individual photons have recently been engineered in several systems...
February 9, 2017: Nature
https://www.readbyqxmd.com/read/28088221/role-of-pelvic-and-para-aortic-lymphadenectomy-in-abandoned-radical-hysterectomy-in-cervical-cancer
#9
Salim Abraham Barquet-Muñoz, Gabriel Jaime Rendón-Pereira, Denise Acuña-González, Monica Vanessa Heymann Peñate, Luis Alonso Herrera-Montalvo, Lenny Nadia Gallardo-Alvarado, David Francisco Cantú-de León, René Pareja
BACKGROUND: Cervical cancer (CC) occupies fourth place in cancer incidence and mortality worldwide in women, with 560,505 new cases and 284,923 deaths per year. Approximately, nine of every ten (87%) take place in developing countries. When a macroscopic nodal involvement is discovered during a radical hysterectomy (RH), there is controversy in the literature between resect macroscopic lymph node compromise or abandonment of the surgery and sending the patient for standard chemo-radiotherapy treatment...
January 14, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28087363/membrane-restructuring-following-in-situ-sialidase-digestion-of-gangliosides-complex-model-bilayers-by-synchrotron-radiation-reflectivity
#10
Valeria Rondelli, Paola Brocca, Giovanna Fragneto, Jean Daillant, Cristina Tringali, Laura Cantu', Elena Del Favero
Synchrotron radiation reflectometry was used to access the transverse structure of model membranes under the action of the human sialidase NEU2, down to the Ångström length scale. Model membranes were designed to mimic the lipid composition of so-called Glycosphingolipids Enriched Microdomains (GEMs), which are membrane platforms specifically enriched in cholesterol and sphingolipids, and where also typical signalling molecules are hosted. Gangliosides, glycosphingolipids containing one or more sialic acid residues, are asymmetrically embedded in GEMs, in the outer membrane leaflet where gangliosides are claimed to interact directly with growth-factor receptors, modulating their activation and then the downstream intracellular signalling pathways...
January 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28077015/atypical-femoral-fractures-mimicking-metastatic-lesions-in-2-patients-taking-denosumab
#11
Daniel C Austin, Michael T Torchia, Christian M Klare, Robert V Cantu
No abstract text is available yet for this article.
January 12, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28076648/latent-class-profile-of-psychiatric-symptoms-and-treatment-utilization-in-a-sample-of-patients-with-co-occurring-disorders
#12
Luis Villalobos-Gallegos, Rodrigo Marín-Navarrete, Calos Roncero, Hugo González-Cantú
Objective: To identify symptom-based subgroups within a sample of patients with co-occurring disorders (CODs) and to analyze intersubgroup differences in mental health services utilization. Methods: Two hundred and fifteen patients with COD from an addiction clinic completed the Symptom Checklist 90-Revised. Subgroups were determined using latent class profile analysis. Services utilization data were collected from electronic records during a 3-year span. Results: The five-class model obtained the best fit (Bayesian information criteria [BIC] = 3,546...
January 9, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28073574/massive-donor-transfusion-potentially-increases-recipient-mortality-after-lung-transplantation
#13
Catherine F Borders, Yoshikazu Suzuki, Jared Lasky, Christian Schaufler, Djamila Mallem, James Lee, Kevin Carney, Scarlett L Bellamy, Christian A Bermudez, A Russell Localio, Jason D Christie, Joshua M Diamond, Edward Cantu
OBJECTIVE: Donor blood transfusion has been identified as a potential risk factor for primary graft dysfunction and by extension early mortality. We sought to define the contributing risk of donor transfusion on early mortality for lung transplant. METHODS: Donor and recipient data were abstracted from the Organ Procurement and Transplantation Network database updated through June 30, 2014, which included 86,398 potential donors and 16,255 transplants. Using the United Network for Organ Sharing 4-level designation of transfusion (no blood, 1-5 units, 6-10 units, and >10 units, massive), we analyzed all-cause mortality at 30-days with the use of logistic regression adjusted for confounders (ischemic time, donor age, recipient diagnosis, lung allocation score and recipient age, and recipient body mass index)...
December 15, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28063606/-assessment-of-antibiotic-use-and-impact-of-an-intervention-intended-to-modify-the-prescribing-behavior-in-surgical-prophylaxis-in-6hospitals-in-the-metropolitan-area-of-monterrey-mexico
#14
Gerardo Del Carmen Palacios-Saucedo, Mauricio de la Garza-Camargo, Evangelina Briones-Lara, Sandra Carmona-González, Ricardo García-Cabello, Luis Arturo Islas-Esparza, Gustavo Saldaña-Flores, Juan Roberto González-Cano, Román González-Ruvalcaba, Francisco Javier Valadez-Botello, Gerardo Enrique Muñoz-Maldonado, Carlos Alberto Montero-Cantú, Rita Delia Díaz-Ramos, Fortino Solórzano-Santos
BACKGROUND: Improper use of antibiotics increases antimicrobial resistance. OBJECTIVE: Evaluate the use of antibiotics and the impact of an intervention designed to improve antibiotic prescription for surgical prophylaxis in 6 hospitals of Monterrey, Mexico. MATERIAL AND METHODS: Design: A prospective multicenter survey and a pretest-postest experimental study. Phase 1: Survey to evaluate the use of antibiotics through an especially designed guide...
January 4, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28056008/traumatic-brain-and-spinal-cord-fatalities-among-high-school-and-college-football-players-united-states-2005-2014
#15
Kristen L Kucera, Rebecca K Yau, Johna Register-Mihalik, Stephen W Marshall, Leah C Thomas, Susanne Wolf, Robert C Cantu, Frederick O Mueller, Kevin M Guskiewicz
An estimated 1.1 million high school and 75,000 college athletes participate in tackle football annually in the United States. Football is a collision sport; traumatic injuries are frequent (1,2), and can be fatal (3). This report updates the incidence and characteristics of deaths caused by traumatic brain injury and spinal cord injury (4) in high school and college football and presents illustrative case descriptions. Information was analyzed from the National Center for Catastrophic Sport Injury Research (NCCSIR)...
January 6, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28052598/oxygen-atom-transfer-using-an-iron-iv-oxo-embedded-in-a-tetracyclic-n-heterocyclic-carbene-system-how-does-the-reactivity-compare-to-cytochrome-p450-compound%C3%A2-i
#16
Fabián G Cantú Reinhard, Sam P de Visser
N-Heterocyclic carbenes (NHC) are commonly featured as ligands in transition metal catalysis. Recently, a cyclic system containing four NHC groups with a central iron atom was synthesized and its iron(IV)-oxo species, [Fe(IV) (O)(cNHC4 )](2+) , was characterized. This tetracyclic NHC ligand system may give the iron(IV)-oxo species unique catalytic properties as compared to traditional non-heme and heme iron ligand systems. Therefore, we performed a computational study on the structure and reactivity of the [Fe(IV) (O)(cNHC4 )](2+) complex in substrate hydroxylation and epoxidation reactions...
January 4, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28051078/clinical-utility-gene-card-for-cant%C3%A3%C2%BA-syndrome
#17
Edwin P Kirk, Ingrid Scurr, Gijs van Haaften, Mieke M van Haelst, Colin G Nichols, Maggie Williams, Sarah F Smithson, Dorothy K Grange
No abstract text is available yet for this article.
January 4, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28038736/-bone-cement-implant-as-an-alternative-for-orbital-floor-reconstruction-a-case-report
#18
Enrique Vargas-Solalinde, Marisol E Huichapa-Padilla, Daniel Garza-Cantú, Víctor H Reyna-Martínez, Julio Alatorre-Ricardo, Juan Luis González-Treviño
BACKGROUND: The management of orbitary fractures is one of the most challenging in facial trauma; the variety of reconstruction materials for its treatment is broad and is constantly improving, but despite this there is no consensus for its use or literature that sustains it. OBJECTIVE: To present the use and design of a preformed bone implant as an alternative for the reconstruction of orbital floor fractures in the pediatric age group. CLINICAL CASE: A 7-year old male who suffered a right hemifacial contusion trauma with clinical and tomographic diagnosis of right pure blowout type orbital floor fracture with inferior rectus muscle entrapment and right post-traumatic palpebral ptosis...
December 27, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28030871/obesity-and-neonatal-cord-blood-gas-results-at-cesarean-effect-of-intraoperative-blood-pressure
#19
Mark F Powell, Charity J Morgan, Jessica A Cantu, Yasser Sakawi, Joseph R Biggio, Alan T N Tita, Jeff M Szychowski, Rodney K Edwards
Objective Our aims were to evaluate whether there is an inverse association between body mass index (BMI) and umbilical artery pH and to investigate the contribution of intraoperative hypotension on the umbilical artery pH. Study Design We conducted a retrospective cohort study of all women with a nonanomalous singleton at 37 to 41 weeks who underwent a scheduled cesarean delivery under spinal anesthesia at our facility from January 2006 to March 2012. The primary outcome was the proportion of patients in each BMI category with arterial cord pH < 7...
December 28, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/28024540/extraction-and-characterization-of-pectins-from-primary-cell-walls-of-edible-a%C3%A3-a%C3%A3-euterpe-oleraceae-berries-fruits-of-a-monocotyledon-palm
#20
Thaisa Moro Cantu-Jungles, Marcello Iacomini, Thales R Cipriani, Lucimara M C Cordeiro
Açaí berries (Euterpe oleracea) are greatly consumed in Brazil and exported to other countries as a nutritional supplement, due to health benefits attributed to its consumption. However, the complete chemical structure of bioactive polysaccharides was not fully elucidated yet. In this work, we characterize pectic polysaccharides from açaí berries through monosaccharide composition, HPSEC, methylation and (13)C and (1)H/(13)C HSQC-DEPT-NMR analyses. A highly methoxylated homogalacturonan with a DM of 88% and Mw of 22kDa together with small amounts of a mannoglucan were found...
February 20, 2017: Carbohydrate Polymers
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