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https://www.readbyqxmd.com/read/28350803/pharmacogenomic-identification-of-small-molecules-for-lineage-specific-manipulation-of-subventricular-zone-germinal-activity
#1
Kasum Azim, Diane Angonin, Guillaume Marcy, Francesca Pieropan, Andrea Rivera, Vanessa Donega, Claudio Cantù, Gareth Williams, Benedikt Berninger, Arthur M Butt, Olivier Raineteau
Strategies for promoting neural regeneration are hindered by the difficulty of manipulating desired neural fates in the brain without complex genetic methods. The subventricular zone (SVZ) is the largest germinal zone of the forebrain and is responsible for the lifelong generation of interneuron subtypes and oligodendrocytes. Here, we have performed a bioinformatics analysis of the transcriptome of dorsal and lateral SVZ in early postnatal mice, including neural stem cells (NSCs) and their immediate progenies, which generate distinct neural lineages...
March 2017: PLoS Biology
https://www.readbyqxmd.com/read/28340130/falling-down-on-the-job-evaluation-and-treatment-of-fall-risk-among-older-adults-with-upper-extremity-fragility-fractures
#2
Christine M McDonough, Carrie H Colla, Donald Carmichael, Anna N A Tosteson, Tor D Tosteson, John-Erik Bell, Robert V Cantu, Jonathan D Lurie, Julie P W Bynum
Background: Clinical practice guidelines recommend fall risk assessment and intervention for older adults who sustain a fall-related injury to prevent future injury and mobility decline. Objective: To describe how often Medicare beneficiaries with upper extremity fracture receive evaluation and treatment for fall risk. Design: Observational cohort. Methods Subjects: Fee-for-service beneficiaries age 66 to 99 treated as outpatients for proximal humerus or distal radius/ulna ("wrist") fragility fractures were studied using Carrier and Outpatient Hospital files...
March 2, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28338755/red-blotch-disease-alters-grape-berry-development-and-metabolism-by-interfering-with-the-transcriptional-and-hormonal-regulation-of-ripening
#3
Barbara Blanco-Ulate, Helene Hopfer, Rosa Figueroa-Balderas, Zirou Ye, Rosa M Rivero, Alfonso Albacete, Francisco Pérez-Alfocea, Renata Koyama, Michael M Anderson, Rhonda J Smith, Susan E Ebeler, Dario Cantu
Grapevine red blotch-associated virus (GRBaV) is a major threat to the wine industry in the USA. GRBaV infections (aka red blotch disease) compromise crop yield and berry chemical composition, affecting the flavor and aroma properties of must and wine. In this study, we combined genome-wide transcriptional profiling with targeted metabolite analyses and biochemical assays to characterize the impact of the disease on red-skinned berry ripening and metabolism. Using naturally infected berries collected from two vineyards, we were able to identify consistent berry responses to GRBaV across different environmental and cultural conditions...
January 27, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28318180/comparison-of-an-increased-waist-circumference-with-a-positive-hydrogen-breath-test-as-a-clinical-predictor-of-lactose-intolerance
#4
Carlos A Zapata-Castilleja, Fernando F Montes-Tapia, Consuelo Treviño-Garza, María C Martínez-Cobos, Jesús García-Cantú, Vincenzo Arenas-Fabbri, Norma de la O-Escamilla, Manuel de la O-Cavazos
INTRODUCTION: Lactose intolerance is a common disease in pediatrics, and its wrong diagnosis will lead to morbidity. The primary objective of this study was to assess the usefulness of an increased waist circumference during the hydrogen breath test as a predictor of lactose intolerance. The secondary objective was to analyze the impact of body mass index, waist circumference measurement, and age on the abdominal distension of patients with lactose intolerance. POPULATION AND METHODS: A total of 138 subjects aged 3 to 15 years were included...
April 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28315410/is-lymphadenectomy-necessary-in-mucinous-ovarian-cancer-a-single-institution-experience
#5
Ivan Salgado-Ceballos, Jazmín Ríos, Delia Pérez-Montiel, Lenny Gallardo, Salim Barquet-Muñoz, Rosa Salcedo-Hernández, Carlos Pérez-Plasencia, Luis Alonso Herrera, David Francisco Cantú de León
BACKGROUND: According to the International Federation of Gynecology and Obstetrics (FIGO) guidelines, every patient diagnosed with ovarian cancer (OC) should undergo a complete staging procedure to adequately assess tumor spread. The role of lymphadenectomy in the initial management of primary early mucinous ovarian cancer (MOC) remains unclear. OBJECTIVE: To describe the prevalence of pelvic and para-aortic node metastases in MOC. MATERIALS AND METHODS: The records of patients with MOC treated at our Institute during January 2005 to December 2011 were assessed...
March 14, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28302527/multiple-plastic-stents-versus-covered-metal-stent-for-treatment-of-anastomotic-biliary-strictures-after-liver-transplantation-a-prospective-randomized-multicenter-trial
#6
Andrea Oliver Tal, Fabian Finkelmeier, Natalie Filmann, Leena Kylänpää, Marianne Udd, Ilaria Parzanese, Paolo Cantù, Alexander Dechêne, Volker Penndorf, Andreas Schnitzbauer, Mireen Friedrich-Rust, Stefan Zeuzem, Jörg G Albert
BACKGROUND AND AIMS: Treatment of anastomotic biliary strictures (ABSs) after orthotopic liver transplantation (OLT) by endoscopic insertion of multiple plastic stents (MPSs) is well-established. The use of covered self-expandable metal stents (cSEMSs) for this indication is less investigated. METHODS: In an open-label, multicenter, randomized trial, patients with confirmed ABSs were randomly assigned 1:1 to receive either an MPS or a cSEMS. Primary endpoint was the number of endoscopic interventions until ABS resolution...
March 13, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28302345/newborn-screening-for-six-lysosomal-storage-disorders-in-a-cohort-of-mexican-patients-three-year-findings-from-a-screening-program-in-a-closed-mexican-health-system
#7
Juana Inés Navarrete-Martínez, Ana Elena Limón-Rojas, Maria de Jesús Gaytán-García, Jesús Reyna-Figueroa, Guillermo Wakida-Kusunoki, Ma Del Rocío Delgado-Calvillo, Consuelo Cantú-Reyna, Héctor Cruz-Camino, David Eduardo Cervantes-Barragán
OBJECTIVE: To evaluate the results of a lysosomal newborn screening (NBS) program in a cohort of 20,018 Mexican patients over the course of 3years in a closed Mexican Health System (Petróleos Mexicanos [PEMEX] Health Services). STUDY DESIGN: Using dried blood spots (DBS), we performed a multiplex tandem mass spectrometry enzymatic assay for six lysosomal storage disorders (LSDs) including Pompe disease, Fabry disease, Gaucher disease, mucopolysaccharidosis type I (MPS-I), Niemann-Pick type A/B, and Krabbe disease...
March 9, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28279597/inferior-vena-cava-filters-in-pulmonary-embolism-a-historic-controversy
#8
Carlos Jerjes-Sanchez, David Rodriguez, Aline Navarrete, Carolina Parra-Cantu, Jorge Joya-Harrison, Eduardo Vazquez, Alicia Ramirez-Rivera
OBJECTIVE: Rationale for non-routine use of inferior venous cava filters (IVCF) in pulmonary embolism (PE) patients. METHODS: Thrombosis mechanisms involved with IVCF placement and removal, the blood-contacting medical device inducing clotting, and the inorganic polyphosphate in the contact activation pathway were analyzed. In addition, we analyzed clinical evidence from randomized trials, including patients with and without cancer. Furthermore, we estimated the absolute risk reduction (ARR), the relative risk reduction (RRR), and the number needed to treat (NNT) based on the results of each study using a frequency table...
March 6, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28276751/development-of-a-laser-controlled-device-to-modulate-intraocular-pressure
#9
REVIEW
Jeffrey L Olson, Ramanath Bhandari, Sergio Groman-Lupa, Daniela Santos-Cantu, Raul Velez-Montoya
The current standard of treatment for glaucoma is trabeculectomy. The use of glaucoma drainage devices has increased in recent years since its efficacy and safety was established as it provides an alternative surgical option. A downfall of these devices is the lack of proper flow rate control. Areas covered: In this paper we describe a glaucoma drainage device regulator that has already been protoyped and undergone initial testing. It consists of an implantable device with a semipermeable membrane that is used during glaucoma surgery and can be opened with either thermal or photodisruptive laser to adjust the amount of flow precisely and non-invasively, addressing the current difficulties of glaucoma surgeries...
March 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28270348/myelodysplasia-and-acute-myeloid-leukemia-fifteen-years-after-high-dose-cyclophosphamide-in-a-child-with-severe-aplastic-anemia
#10
José Carlos Jaime-Pérez, Liliana Nataly Guerra-Leal, Olga Graciela Cantú-Rodríguez, David Gómez-Almaguer
No abstract text is available yet for this article.
January 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/28269630/simulating-the-activation-contraction-and-movement-of-skeletal-muscles-using-the-bidomain-model
#11
A Lopez Rincon, C Cantu, R Soto, S Shimoda
A simulation of the muscle activation, contraction and movement is here presented. This system was developed based on the Bidomain mathematical model of the electrical propagation in muscles. This study shows an electrical stimuli input to a muscle and how this behave. The comparison between healthy subject and patient with muscle activation impairment is depicted, depending on whether the signal reaches a threshold. A 3D model of a bicep muscle and a forearm bone connected was constructed using OpenGL. This platform could be used for development of controllers for biomechatronic systems in future works...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267463/early-inpatient-calculation-of-laboratory-based-30-day-readmission-risk-scores-empowers-clinical-risk-modification-during-index-hospitalization
#12
Benjamin D Horne, Deborah Budge, Andrew L Masica, Lucy A Savitz, José Benuzillo, Gabriela Cantu, Alejandra Bradshaw, Raymond O McCubrey, Tami L Bair, Colleen A Roberts, Kismet D Rasmusson, Rami Alharethi, Abdallah G Kfoury, Brent C James, Donald L Lappé
Improving 30-day readmission continues to be problematic for most hospitals. This study reports the creation and validation of sex-specific inpatient (i) heart failure (HF) risk scores using electronic data from the beginning of inpatient care for effective and efficient prediction of 30-day readmission risk. METHODS: HF patients hospitalized at Intermountain Healthcare from 2005 to 2012 (derivation: n=6079; validation: n=2663) and Baylor Scott & White Health (North Region) from 2005 to 2013 (validation: n=5162) were studied...
March 2017: American Heart Journal
https://www.readbyqxmd.com/read/28266849/palladium-ii-catalyzed-directed-anti-hydrochlorination-of-unactivated-alkynes-with-hcl
#13
Joseph Derosa, Annabelle L Cantu, Mark N Boulous, Miriam L O'Duill, Joshua L Turnbull, Zhen Liu, Daizy M De La Torre, Keary M Engle
A regioselective anti-hydrochlorination of unactivated alkynes is reported. The reaction utilizes in situ generated HCl as the source of both the Cl(-) and H(+) and is catalyzed by palladium(II) acetate, with loadings as low as 25 ppm. Removable picolinamide and 8-aminoquinoline bidentate directing groups are used to control the regioselectivity of the chloropalladation step and stabilize the resulting vinylpalladium(II) intermediate for subsequent protodepalladation. This method provides access to a broad array of substituted vinyl chlorides in excellent yields and with high regioselectivity...
March 7, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28264907/increased-pilus-production-conferred-by-a-naturally-occurring-mutation-alters-host-pathogen-interaction-in-favor-of-carriage-in-streptococcus-pyogenes
#14
Anthony R Flores, Randall J Olsen, Concepcion Cantu, Kyler B Pallister, Fermin E Guerra, Jovanka M Voyich, James M Musser
Studies of the human pathogen group A Streptococcus (GAS) define the carrier phenotype as increased ability to adhere to and persist on epithelial surfaces and decreased ability to cause disease. We tested the hypothesis that a single amino acid change (Arg135Gly) in a highly conserved sensor kinase (LiaS) of a poorly defined GAS regulatory system contributes to a carrier phenotype through increased pilus production. When introduced into an emm serotype-matched invasive strain, the carrier allele (liaS(R135G)) recapitulated a carrier phenotype defined by increased ability to adhere to mucosal surfaces and decreased ability to cause disease...
March 6, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28261884/modulation-of-antimalarial-activity-at-a-putative-bisquinoline-receptor-in-vivo-using-fluorinated-bisquinolines
#15
Alistar John Fielding, Valentina Lukinovic, Philip Evans, Said Alizadeh, Roger Bisby, Mike Drew, Alessio Del Casino, James Dunn, Laura Randle, Nicola Dempster, Nahar Lutfun, Sarker Satyajit, Fabián G Cantú Reinhard, Sam P de Visser, Mike Dascombe, Fyaz Ismail
Antimalarials can interact with heme covalently, by - interactions or hydrogen bonding. Consequently, the prototropy of 4-aminoquinolines and quinoline methanols was investigated using quantum mechanics. Calculations showed mefloquine protonated preferentially at the piperidine and was impeded at the endocyclic nitrogen due to electronic rather than steric factors. In gas phase calculations, 7-substituted mono- and bis-4-aminoquinolines were preferentially protonated at the endocyclic quinoline nitrogen...
March 6, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28242077/ex%C3%A2-vivo-lung-perfusion-model-to-study-pulmonary-tissue-extracellular-microvesicle-profiles
#16
Prashanth Vallabhajosyula, Laxminarayana Korutla, Andreas Habertheuer, Sanjana Reddy, Christian Schaufler, Jared Lasky, Joshua Diamond, Edward Cantu
BACKGROUND: Extracellular microvesicles (EVs) are being increasingly studied for their diagnostic potential. We investigated the feasibility of studying the kinetics and tissue-specific profiles of pulmonary EVs in the context of ex vivo lung perfusion (EVLP) used for salvaging marginal lungs for transplantation. METHODS: Perfusate from six marginal donor lungs placed on EVLP was collected at the following time points: 0, 10, and 60 minutes after and after perfusate exchange with Steen Solution; 120 and 180 minutes...
February 24, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28229128/repetitive-head-impact-exposure-and-later-life-plasma-total-tau-in-former-national-football-league-players
#17
Michael L Alosco, Yorghos Tripodis, Johnny Jarnagin, Christine M Baugh, Brett Martin, Christine E Chaisson, Nate Estochen, Linan Song, Robert C Cantu, Andreas Jeromin, Robert A Stern
INTRODUCTION: Blood protein analysis of total tau (t-tau) may be a practical screening biomarker for chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy associated with repetitive head impact (RHI) exposure. We examined plasma t-tau in symptomatic former National Football League (NFL) players compared with controls and the relationship between RHI exposure and later-life plasma t-tau. METHODS: Ninety-six former NFL players (age 40-69) and 25 same-age controls underwent blood draw to determine plasma t-tau levels...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28227888/simulating-the-activation-contraction-and-movement-of-skeletal-muscles-using-the-bidomain-model
#18
A Lopez Rincon, C Cantu, R Soto, S Shimoda, A Lopez Rincon, C Cantu, R Soto, S Shimoda, A Lopez Rincon, R Soto, C Cantu, S Shimoda
A simulation of the muscle activation, contraction and movement is here presented. This system was developed based on the Bidomain mathematical model of the electrical propagation in muscles. This study shows an electrical stimuli input to a muscle and how this behave. The comparison between healthy subject and patient with muscle activation impairment is depicted, depending on whether the signal reaches a threshold. A 3D model of a bicep muscle and a forearm bone connected was constructed using OpenGL. This platform could be used for development of controllers for biomechatronic systems in future works...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226327/measurements-of-catheter-venous-and-capillary-cyclosporine-a-blood-are-comparable-and-useful-in-pediatric-hematopoietic-stem-cell-transplant-recipients
#19
Oscar González-Llano, Consuelo Mancías-Guerra, Carmen Magdalena Gamboa-Alonso, Andrés Gómez-De León, José Carlos Jaime-Pérez, César Homero Gutiérrez-Aguirre, Olga Cantú-Rodríguez, Laura Villarreal-Martínez, Ricardo García-Sepulveda, Miguel Angel Herrera-Rojas, David Gómez-Almaguer
No abstract text is available yet for this article.
2017: Acta Haematologica
https://www.readbyqxmd.com/read/28223967/secretome-prediction-of-two-m-tuberculosis-clinical-isolates-reveals-their-high-antigenic-density-and-potential-drug-targets
#20
Fernanda Cornejo-Granados, Zyanya L Zatarain-Barrón, Vito A Cantu-Robles, Alfredo Mendoza-Vargas, Camilo Molina-Romero, Filiberto Sánchez, Luis Del Pozo-Yauner, Rogelio Hernández-Pando, Adrián Ochoa-Leyva
The Excreted/Secreted (ES) proteins play important roles during Mycobacterium tuberculosis invasion, virulence, and survival inside the host and they are a major source of immunogenic proteins. However, the molecular complexity of the bacillus cell wall has made difficult the experimental isolation of the total bacterial ES proteins. Here, we reported the genomes of two Beijing genotype M. tuberculosis clinical isolates obtained from patients from Vietnam (isolate 46) and South Africa (isolate 48). We developed a bioinformatics pipeline to predict their secretomes and observed that ~12% of the genome-encoded proteins are ES, being PE, PE-PGRS, and PPE the most abundant protein domains...
2017: Frontiers in Microbiology
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