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https://www.readbyqxmd.com/read/28641814/an-interferometric-technique-to-study-capillary-waves
#1
REVIEW
Laura Cantu', Antonio Raudino, Mario Corti
We describe a new interferometric technique to study gas-liquid and liquid-liquid interfaces. Bubbles and drops are subjected to an alternating electric field which excites capillary oscillations at the interface, if charged. Bubble or drop deformation is detected by the change of the internal optical path of a laser beam crossing perpendicular to the oscillation axis. Due to the closed geometry, a discrete spectrum of stationary oscillation frequencies (normal modes) is excited. The interferometric nature of the measurement and the resonant nature of the oscillation modes concur in allowing for high sensitivity, in the sub-nanometric region...
June 15, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28639897/gene-signature-based-on-degradome-related-genes-can-predict-distal-metastasis-in-cervical-cancer-patients
#2
Jorge Fernandez-Retana, Horacio Zamudio-Meza, Miguel Rodriguez-Morales, Abraham Pedroza-Torres, David Isla-Ortiz, Luis Herrera, Nadia Jacobo-Herrera, Oscar Peralta-Zaragoza, César López-Camarillo, Fermin Morales-Gonzalez, David Cantu de Leon, Carlos Pérez-Plasencia
Cervical cancer is one of the leading causes of death in women worldwide, which mainly affects developing countries. The patients who suffer a recurrence and/or progression disease have a higher risk of developing distal metastases. Proteases comprising the degradome given its ability to promote cell growth, migration, and invasion of tissues play an important role during tumor development and progression. In this study, we used high-density microarrays and quantitative reverse transcriptase polymerase chain reaction to evaluate the degradome profile and their inhibitors in 112 samples of patients diagnosed with locally advanced cervical cancer...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28637176/dissociation-of-striatal-dopamine-and-tyrosine-hydroxylase-expression-from-aging-related-motor-decline-evidence-from-calorie-restriction-intervention
#3
Michael F Salvatore, Jennifer Terrebonne, Mark A Cantu, Tamara R McInnis, Katy Venable, Parker Kelley, Ella A Kasanga, Brian Latimer, Catherine L Owens, Brandon S Pruett, Yongmei Yu, Robert Luedtke, Michael J Forster, Nathalie Sumien, Donald K Ingram
The escalating increase in retirees living beyond their 8th decade brings increased prevalence of aging-related impairments, including locomotor impairment (Parkinsonism) which may affect ~50% of those reaching age 80, but has no confirmed neurobiological mechanism. Lifestyle strategies that attenuate motor decline, and its allied mechanisms, must be identified. Aging studies report little to moderate loss of striatal dopamine (DA) or tyrosine hydroxylase (TH) in nigrostriatal terminals, in contrast to ~70-80% loss associated with bradykinesia onset in Parkinson's disease...
June 20, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28631864/ceftriaxone-reduces-l-dopa-induced-dyskinesia-severity-in-6-hydroxydopamine-parkinson-s-disease-model
#4
Tanya Chotibut, Samantha Meadows, Ella A Kasanga, Tamara McInnis, Mark A Cantu, Christopher Bishop, Michael F Salvatore
BACKGROUND: Increased extracellular glutamate may contribute to l-dopa induced dyskinesia, a debilitating side effect faced by Parkinson's disease patients 5 to 10 years after l-dopa treatment. Therapeutic strategies targeting postsynaptic glutamate receptors to mitigate dyskinesia may have limited success because of significant side effects. Increasing glutamate uptake may be another approach to attenuate excess glutamatergic neurotransmission to mitigate dyskinesia severity or prolong the time prior to onset...
June 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28627835/clinical-and-molecular-delineation-of-a-novel-cys1050phe-missense-mutation-in-the-abcc9-gene-in-a-korean-patient-with-cant%C3%A3%C2%BA-syndrome
#5
HyoIn Kim, SeongWoo Kim, HaRa Jeon, JiYong Kim, JongHa Yoo, MoonWoo Seong, SungSup Park
Cantú syndrome is characterized by congenital hypertrichosis, cardiomegaly, and osteochondrodysplasia and is recognized as a rare syndrome. Although it has previously been reported that the majority of affected individuals have a relatively good prognosis, there are no reports on long-term follow up. Here we report the first case of Cantú syndrome in Korea and the associated changes in overall development with rehabilitation over several months.
May 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28627179/water-lean-solvents-for-post-combustion-co2-capture-fundamentals-uncertainties-opportunities-and-outlook
#6
David J Heldebrant, Phillip K Koech, Vassiliki-Alexandra Glezakou, Roger Rousseau, Deepika Malhotra, David C Cantu
This review is designed to foster the discussion regarding the viability of postcombustion CO2 capture by water-lean solvents, by separating fact from fiction for both skeptics and advocates. We highlight the unique physical and thermodynamic properties of notable water-lean solvents, with a discussion of how such properties could translate to efficiency gains compared to aqueous amines. The scope of this review ranges from the purely fundamental molecular-level processes that govern solvent behavior to bench-scale testing, through process engineering and projections of process performance and cost...
June 19, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28624384/a-giant-coronary-artery-aneurysm-treated-using-multiple-overlapping-covered-stents
#7
Alberto F Cereda, Gianluca Tiberti, Isidoro G Pera, Edoardo Cantù, Luca A Ferri, Stefano Savonitto, Luigi Piatti
No abstract text is available yet for this article.
June 7, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28621447/metformin-prevents-vascular-prostanoid-release-alterations-induced-by-a-high-fat-diet-in-rats
#8
H J Lee, S M Cantú, A S Donoso, M R Choi, H A Peredo, A M Puyó
Perivascular adipose tissue dysfunction induced by high-fat feeding leads to alterations in the modulation of inflammation, contractile activity of the vascular smooth muscle and endothelial function, all risk factors in the development of hypertension. Metformin, an activator of AMP-activated protein kinase (AMPK), is currently the first-line drug treatment for type 2 diabetes (T2DM) and metabolic syndrome. Besides its glucose-lowering effect, there is an interest in actions of this drug with potential relevance in cardiovascular diseases...
June 16, 2017: Autonomic & Autacoid Pharmacology
https://www.readbyqxmd.com/read/28607173/tactile-defensiveness-and-impaired-adaptation-of-neuronal-activity-in-the-fmr1-knockout-mouse-model-of-autism
#9
Cynthia X He, Daniel A Cantu, Shilpa S Mantri, William A Zeiger, Anubhuti Goel, Carlos Portera-Cailliau
Sensory hypersensitivity is a common symptom in autism spectrum disorders (ASDs), including Fragile X Syndrome (FXS), and frequently leads to tactile defensiveness. In mouse models of ASDs, there is mounting evidence of neuronal and circuit hyperexcitability in several brain regions, which could contribute to sensory hypersensitivity. However, it is not yet known whether or how sensory stimulation might trigger abnormal sensory processing at the circuit level or abnormal behavioral responses in ASD mouse models, especially during an early developmental time when experience-dependent plasticity shapes such circuits...
June 12, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28602902/case-report-a-durable-open-repair-of-a-rare-profunda-aneurysm
#10
Pouria Parsa, Anthony Rios, Kristha Cantu, John Eidt, Dennis Gable, Gregory Pearl
Profunda femoris artery aneurysms (PFAAs) are rare and difficult to diagnose in the early stages of development due to location and encasement in the deep thigh musculature. We report the case of a 74-year-old male who was discovered to have a right PFAA during evaluation for progressively worsening short distance claudication. He had undergone an angioplasty of the left iliofemoral system several months ago with no improvement of his symptoms. The PFAA was diagnosed through CT angiography and repaired via syndactylization of profunda femoris branches and interposition grafting with a polytetrafluoroethylene stretch graft...
June 7, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28598347/ingestion-of-swimming-pool-water-by-recreational-swimmers
#11
A P Dufour, T D Behymer, R Cantú, M Magnuson, L J Wymer
The volume of water ingested by swimmers while swimming is of great interest to individuals who develop risk assessments using quantitative microbial risk assessment or epidemiological approaches. We have used chloroisocyanurate disinfected swimming pool waters to determine the amount of water swallowed by swimmers during swimming activity. The chloroisocyanurate, which is in equilibrium with chlorine and cyanuric acid in the pool water, provides a biomarker, cyanuric acid, that once swallowed passes through the body into the urine unchanged...
June 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/28590243/detection-of-actinomyces-spp-in-cervical-exudates-from-women-with-cervical-intraepithelial-neoplasia-or-cervical-cancer
#12
Alejandra García-García, Jaime Coronel-Martínez, David Cantú-de Leon, María Del Socorro Romero-Figueroa, Yolanda Elizabeth Caballero-Pantoja, Gauddy Lizeth Manzanares-Leal, Miguel Rodriguez-Morales, Horacio Sandoval-Trujillo, Ninfa Ramírez-Durán
PURPOSE: Under certain circumstances, Actinomyces behaves as an opportunistic microorganism and can cause actinomycosis, a chronic and inflammatory granulomatous infection. The purpose of this project was to detect the presence of Actinomyces in cervical exudates from women with cervical intraepithelial neoplasia (CIN) and women with cervical cancer. METHODOLOGY: Cervical samples from 92 women were divided into three groups: CIN, cervical cancer and healthy women...
June 8, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28584062/cytochrome-b5-reductase-3-modulates-soluble-guanylate-cyclase-redox-state-and-cgmp-signaling
#13
Mizanur M Rahaman, Anh T Nguyen, Megan P Miller, Scott A Hahn, Courtney Sparacino-Watkins, Soma Jobbagy, Nolan T Carew, Nadiezhda Cantu-Medellin, Katherine C Wood, Catherine Baty, Francisco J Schopfer, Eric E Kelley, Mark T Gladwin, Emil Martin, Adam C Straub
Rationale: Soluble guanylate cyclase (sGC) heme iron, in its oxidized state (Fe(3+)), is desensitized to nitric oxide (NO) and limits cyclic guanosine 3', 5'-monophosphate (cGMP) production needed for downstream activation of PKG-dependent signaling and blood vessel dilation. Objective: While reactive oxygen species are known to oxidize the sGC heme iron, the basic mechanism(s) governing sGC heme iron recycling to its NO-sensitive, reduced state, remain poorly understood. Methods and Results: Oxidant challenge studies show vascular smooth muscle cells have an intrinsic ability to reduce oxidized sGC heme iron and form protein-protein complexes between cytochrome b5 reductase 3 (Cyb5R3), also known as methemoglobin reductase, and oxidized sGC...
June 5, 2017: Circulation Research
https://www.readbyqxmd.com/read/28567052/how-single-molecule-real-time-sequencing-and-haplotype-phasing-have-enabled-reference-grade-diploid-genome-assembly-of-wine-grapes
#14
Andrea Minio, Jerry Lin, Brandon S Gaut, Dario Cantu
No abstract text is available yet for this article.
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28549297/diabetes-care-provider-perceptions-on-family-challenges-of-pediatric-type-1-diabetes
#15
Maria J Redondo, Chishinga S Callender, Caroline Gonynor, Dora Cantu, Karen W Cullen, Barbara Anderson, Debbe Thompson
Pediatric healthcare providers' perspectives on barriers to diabetes self-management among youth with type 1 diabetes and strategies to overcome them were explored qualitatively. Family conflict about diabetes care was viewed as a common problem, addressable by behavioral interventions to improve communication and promote family teamwork in diabetes management responsibilities.
July 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28544340/a-high-valent-non-heme-%C3%AE-oxo-manganese-iv-dimer-generated-from-a-thiolate-bound-manganese-ii-complex-and-dioxygen
#16
Deborah Brazzolotto, Fabián G Cantú Reinhard, Julian Smith-Jones, Marius Retegan, Lucia Amidani, Abayomi S Faponle, Kallol Ray, Christian Philouze, Sam P de Visser, Marcello Gennari, Carole Duboc
This study deals with the unprecedented reactivity of dinuclear non-heme Mn(II) -thiolate complexes with O2 , which dependent on the protonation state of the initial Mn(II) dimer selectively generates either a di-μ-oxo or μ-oxo-μ-hydroxo Mn(IV) complex. Both dimers have been characterized by different techniques including single-crystal X-ray diffraction and mass spectrometry. Oxygenation reactions carried out with labeled (18) O2 unambiguously show that the oxygen atoms present in the Mn(IV) dimers originate from O2 ...
May 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28540021/minimally-invasive-surgery-for-the-removal-of-posterior-intraocular-foreign-bodies
#17
Jesus Hernan Gonzalez-Cortes, Yunuen Bages-Rousselon, Jesus Emiliano Gonzalez-Cantu, Jesus Mohamed-Hamsho
This is a prospective clinical assay that included six patients who were diagnosed with penetrating corneal injury, traumatic cataract, and posterior segment intraocular foreign body (IOFB). Following anterior segment repair and extraction of traumatic cataract by clear cornea phacoemulsification, a standard 25-gauge transconjunctival pars plana vitrectomy was performed to find and release the IOFB. With active suction using a 25-gauge silicone tipped cannula, the foreign body was retrieved and safely placed in the anterior chamber...
April 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28536097/dynamic-regulation-of-vegf-inducible-genes-by-an-erk-erg-p300-transcriptional-network
#18
Jason E Fish, Manuel Cantu Gutierrez, Lan T Dang, Nadiya Khyzha, Zhiqi Chen, Shawn Veitch, Henry S Cheng, Melvin Khor, Lina Antounians, Makon-Sébastien Njock, Emilie Boudreau, Alexander M Herman, Alexander M Rhyner, Oscar E Ruiz, George T Eisenhoffer, Alejandra Medina-Rivera, Michael D Wilson, Joshua D Wythe
The transcriptional pathways activated downstream of Vascular Endothelial Growth Factor (VEGF) signaling during angiogenesis remain incompletely characterized. By assessing the signals responsible for induction of the Notch ligand, Delta-Like 4 (DLL4) in endothelial cells we find that activation of the MAPK/ERK pathway mirrors the rapid and dynamic induction of DLL4 transcription and that this pathway is required for DLL4 expression. Furthermore, VEGF/ERK signaling induces phosphorylation and activation of the ETS transcription factor ERG, a prerequisite for DLL4 induction...
May 23, 2017: Development
https://www.readbyqxmd.com/read/28521071/pharmacological-interventions-in-the-wnt-pathway-inhibition-of-wnt-secretion-versus-disrupting-the-protein-protein-interfaces-of-nuclear-factors
#19
REVIEW
Dario Zimmerli, George Hausmann, Claudio Cantù, Konrad Basler
Mutations in components of the Wnt pathways are a frequent cause of many human diseases, particularly cancer. Despite the fact that a causative link between aberrant Wnt signaling and many types of human cancers was established more than a decade ago, no Wnt signaling inhibitors have made it into the clinic so far. One reason for this is that no pathway-specific kinase is known. Additionally targeting the protein-protein interactions needed to transduce the signal has not met with success so far. Complicating the search for and use of inhibitors is the complexity of the cascades triggered by the Wnts and their paramount biological importance...
May 18, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28502484/pathogenic-a%C3%AE-a2v-versus-protective-a%C3%AE-a2t-mutation-early-stage-aggregation-and-membrane-interaction
#20
Laura Colombo, Alessio Gamba, Laura Cantù, Mario Salmona, Fabrizio Tagliavini, Valeria Rondelli, Elena Del Favero, Paola Brocca
We investigated the effects of punctual A-to-V and A-to-T mutations in the amyloid precursor protein APP, corresponding to position 2 of Aβ1-42. Those mutations had opposite effects on the onset and progression of Alzheimer disease, the former inducing early AD pathology and the latter protecting against the onset of the disease. We applied Static and Dynamic Light Scattering and Circular Dichroism, to study the different mutants in the early stages of the aggregation process, essential for the disease. Comparative results showed that the aggregation pathways differ in the kinetics and extent of the process, in the size of the aggregates and in the evolution of the secondary structure, resulting in fibrils of different morphology, as seen by AFM...
May 6, 2017: Biophysical Chemistry
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