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https://www.readbyqxmd.com/read/28088221/role-of-pelvic-and-para-aortic-lymphadenectomy-in-abandoned-radical-hysterectomy-in-cervical-cancer
#1
Salim Abraham Barquet-Muñoz, Gabriel Jaime Rendón-Pereira, Denise Acuña-González, Monica Vanessa Heymann Peñate, Luis Alonso Herrera-Montalvo, Lenny Nadia Gallardo-Alvarado, David Francisco Cantú-de León, René Pareja
BACKGROUND: Cervical cancer (CC) occupies fourth place in cancer incidence and mortality worldwide in women, with 560,505 new cases and 284,923 deaths per year. Approximately, nine of every ten (87%) take place in developing countries. When a macroscopic nodal involvement is discovered during a radical hysterectomy (RH), there is controversy in the literature between resect macroscopic lymph node compromise or abandonment of the surgery and sending the patient for standard chemo-radiotherapy treatment...
January 14, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28087363/membrane-restructuring-following-in-situ-sialidase-digestion-of-gangliosides-complex-model-bilayers-by-synchrotron-radiation-reflectivity
#2
Valeria Rondelli, Paola Brocca, Giovanna Fragneto, Jean Daillant, Cristina Tringali, Laura Cantu', Elena Del Favero
Synchrotron radiation reflectometry was used to access the transverse structure of model membranes under the action of the human sialidase NEU2, down to the Ångström length scale. Model membranes were designed to mimic the lipid composition of so-called Glycosphingolipids Enriched Microdomains (GEMs), which are membrane platforms specifically enriched in cholesterol and sphingolipids, where also typical signalling molecules are hosted. Gangliosides, glycosphingolipids containing one or more sialic acid residues, are asymmetrically embedded in GEMs, in the outer membrane leaflet...
January 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28077015/atypical-femoral-fractures-mimicking-metastatic-lesions-in-2-patients-taking-denosumab
#3
Daniel C Austin, Michael T Torchia, Christian M Klare, Robert V Cantu
No abstract text is available yet for this article.
January 12, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28076648/latent-class-profile-of-psychiatric-symptoms-and-treatment-utilization-in-a-sample-of-patients-with-co-occurring-disorders
#4
Luis Villalobos-Gallegos, Rodrigo Marín-Navarrete, Calos Roncero, Hugo González-Cantú
Objective: To identify symptom-based subgroups within a sample of patients with co-occurring disorders (CODs) and to analyze intersubgroup differences in mental health services utilization. Methods: Two hundred and fifteen patients with COD from an addiction clinic completed the Symptom Checklist 90-Revised. Subgroups were determined using latent class profile analysis. Services utilization data were collected from electronic records during a 3-year span. Results: The five-class model obtained the best fit (Bayesian information criteria [BIC] = 3,546...
January 9, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28073574/massive-donor-transfusion-potentially-increases-recipient-mortality-after-lung-transplantation
#5
Catherine F Borders, Yoshikazu Suzuki, Jared Lasky, Christian Schaufler, Djamila Mallem, James Lee, Kevin Carney, Scarlett L Bellamy, Christian A Bermudez, A Russell Localio, Jason D Christie, Joshua M Diamond, Edward Cantu
OBJECTIVE: Donor blood transfusion has been identified as a potential risk factor for primary graft dysfunction and by extension early mortality. We sought to define the contributing risk of donor transfusion on early mortality for lung transplant. METHODS: Donor and recipient data were abstracted from the Organ Procurement and Transplantation Network database updated through June 30, 2014, which included 86,398 potential donors and 16,255 transplants. Using the United Network for Organ Sharing 4-level designation of transfusion (no blood, 1-5 units, 6-10 units, and >10 units, massive), we analyzed all-cause mortality at 30-days with the use of logistic regression adjusted for confounders (ischemic time, donor age, recipient diagnosis, lung allocation score and recipient age, and recipient body mass index)...
December 15, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28063606/-assessment-of-antibiotic-use-and-impact-of-an-intervention-intended-to-modify-the-prescribing-behavior-in-surgical-prophylaxis-in-6hospitals-in-the-metropolitan-area-of-monterrey-mexico
#6
Gerardo Del Carmen Palacios-Saucedo, Mauricio de la Garza-Camargo, Evangelina Briones-Lara, Sandra Carmona-González, Ricardo García-Cabello, Luis Arturo Islas-Esparza, Gustavo Saldaña-Flores, Juan Roberto González-Cano, Román González-Ruvalcaba, Francisco Javier Valadez-Botello, Gerardo Enrique Muñoz-Maldonado, Carlos Alberto Montero-Cantú, Rita Delia Díaz-Ramos, Fortino Solórzano-Santos
BACKGROUND: Improper use of antibiotics increases antimicrobial resistance. OBJECTIVE: Evaluate the use of antibiotics and the impact of an intervention designed to improve antibiotic prescription for surgical prophylaxis in 6 hospitals of Monterrey, Mexico. MATERIAL AND METHODS: Design: A prospective multicenter survey and a pretest-postest experimental study. Phase 1: Survey to evaluate the use of antibiotics through an especially designed guide...
January 4, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28056008/traumatic-brain-and-spinal-cord-fatalities-among-high-school-and-college-football-players-united-states-2005-2014
#7
Kristen L Kucera, Rebecca K Yau, Johna Register-Mihalik, Stephen W Marshall, Leah C Thomas, Susanne Wolf, Robert C Cantu, Frederick O Mueller, Kevin M Guskiewicz
An estimated 1.1 million high school and 75,000 college athletes participate in tackle football annually in the United States. Football is a collision sport; traumatic injuries are frequent (1,2), and can be fatal (3). This report updates the incidence and characteristics of deaths caused by traumatic brain injury and spinal cord injury (4) in high school and college football and presents illustrative case descriptions. Information was analyzed from the National Center for Catastrophic Sport Injury Research (NCCSIR)...
January 6, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28052598/oxygen-atom-transfer-using-an-iron-iv-oxo-embedded-in-a-tetracyclic-n-heterocyclic-carbene-system-how-does-the-reactivity-compare-to-cytochrome-p450-compound
#8
Samuel de Visser, Fabian Cantu Reinhard
N-heterocyclic carbenes (NHC) are common catalyst features in transition metal chemistry. Recently, a cyclic system containing four NHC groups with a central iron atom was synthesized and its iron(IV)-oxo characterized, [FeIV(O)(cNHC4)]2+. This tetra-cyclic NHC ligand system may give the iron(IV)-oxo species unique catalytic properties as compared to traditional nonheme iron and heme iron ligand systems. Therefore, we performed a computational study on the structure and reactivity of the [FeIV(O)(cNHC4)]2+ complex in substrate hydroxylation and epoxidation reactions...
January 4, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28051078/clinical-utility-gene-card-for-cant%C3%A3%C2%BA-syndrome
#9
Edwin P Kirk, Ingrid Scurr, Gijs van Haaften, Mieke M van Haelst, Colin G Nichols, Maggie Williams, Sarah F Smithson, Dorothy K Grange
No abstract text is available yet for this article.
January 4, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28038736/-bone-cement-implant-as-an-alternative-for-orbital-floor-reconstruction-a-case-report
#10
Enrique Vargas-Solalinde, Marisol E Huichapa-Padilla, Daniel Garza-Cantú, Víctor H Reyna-Martínez, Julio Alatorre-Ricardo, Juan Luis González-Treviño
BACKGROUND: The management of orbitary fractures is one of the most challenging in facial trauma; the variety of reconstruction materials for its treatment is broad and is constantly improving, but despite this there is no consensus for its use or literature that sustains it. OBJECTIVE: To present the use and design of a preformed bone implant as an alternative for the reconstruction of orbital floor fractures in the pediatric age group. CLINICAL CASE: A 7-year old male who suffered a right hemifacial contusion trauma with clinical and tomographic diagnosis of right pure blowout type orbital floor fracture with inferior rectus muscle entrapment and right post-traumatic palpebral ptosis...
December 27, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28030871/obesity-and-neonatal-cord-blood-gas-results-at-cesarean-effect-of-intraoperative-blood-pressure
#11
Mark F Powell, Charity J Morgan, Jessica A Cantu, Yasser Sakawi, Joseph R Biggio, Alan T N Tita, Jeff M Szychowski, Rodney K Edwards
Objective Our aims were to evaluate whether there is an inverse association between body mass index (BMI) and umbilical artery pH and to investigate the contribution of intraoperative hypotension on the umbilical artery pH. Study Design We conducted a retrospective cohort study of all women with a nonanomalous singleton at 37 to 41 weeks who underwent a scheduled cesarean delivery under spinal anesthesia at our facility from January 2006 to March 2012. The primary outcome was the proportion of patients in each BMI category with arterial cord pH < 7...
December 28, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/28024540/extraction-and-characterization-of-pectins-from-primary-cell-walls-of-edible-a%C3%A3-a%C3%A3-euterpe-oleraceae-berries-fruits-of-a-monocotyledon-palm
#12
Thaisa Moro Cantu-Jungles, Marcello Iacomini, Thales R Cipriani, Lucimara M C Cordeiro
Açaí berries (Euterpe oleracea) are greatly consumed in Brazil and exported to other countries as a nutritional supplement, due to health benefits attributed to its consumption. However, the complete chemical structure of bioactive polysaccharides was not fully elucidated yet. In this work, we characterize pectic polysaccharides from açaí berries through monosaccharide composition, HPSEC, methylation and (13)C and (1)H/(13)C HSQC-DEPT-NMR analyses. A highly methoxylated homogalacturonan with a DM of 88% and Mw of 22kDa together with small amounts of a mannoglucan were found...
February 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28004518/reinventing-design-principles-for-developing-low-viscosity-carbon-dioxide-binding-organic-liquids-co2bols-for-flue-gas-clean-up
#13
Phillip Koech, Deepika Malhotra, David J Heldebrant, David C Cantu, Feng Zheng, Vassiliki-Alexandra Glezakou, Roger Rousseau
Anthropogenic carbon dioxide (CO2) emissions from point sources account for the majority of greenhouse gases in the atmosphere. Capture and storage are required to mitigate adverse environmental effects. Aqueous amine-based solvents are currently considered the industry standard, but deployment to market is limited by their high regeneration energy. In that context, water-lean solvent systems such as CO2 binding organic liquids (CO2BOLs) are being developed to reduce this energy requirement for CO2 capture...
December 21, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27994459/the-nasal-delivery-of-nanoencapsulated-statins-an-approach-for-brain-delivery
#14
Adryana Clementino, Mellissa Batger, Gabriela Garrastazu, Michele Pozzoli, Elena Del Favero, Valeria Rondelli, Bianca Gutfilen, Thiago Barboza, Maria B Sukkar, Sergio A L Souza, Laura Cantù, Fabio Sonvico
PURPOSE: Along with their cholesterol-lowering effect, statins have shown a wide range of pleiotropic effects potentially beneficial to neurodegenerative diseases. However, such effects are extremely elusive via the conventional oral administration. The purpose of the present study was to prepare and characterize the physicochemical properties and the in vivo biodistribution of simvastatin-loaded lecithin/chitosan nanoparticles (SVT-LCNs) suitable for nasal administration in view of an improved delivery of the statins to the brain...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27989783/the-binding-effectiveness-of-anti-rdisintegrin-polyclonal-antibodies-against-disintegrins-and-pii-and-piii-metalloproteases-an-immunological-survey-of-type-a-b-and-a-b-venoms-from-mohave-rattlesnakes
#15
Esteban Cantú, Sahiti Mallela, Matthew Nyguen, Raúl Báez, Victoria Parra, Rachel Johnson, Kyle Wilson, Montamas Suntravat, Sara Lucena, Alexis Rodríguez-Acosta, Elda E Sánchez
Snake venoms are known to have different venom compositions and toxicity, but differences can also be found within populations of the same species contributing to the complexity of treatment of envenomated victims. One of the first well-documented intraspecies venom variations comes from the Mohave rattlesnake (Crotalus scutulatus scutulatus). Initially, three types of venoms were described; type A venom is the most toxic as a result of ~45% Mojave toxin in the venom composition, type B lacks the Mojave toxin but contains over 50% of snake venom metalloproteases (SVMP)...
October 27, 2016: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/27989765/chitosan-coupled-solid-lipid-nanoparticles-tuning-nanostructure-and-mucoadhesion
#16
Giuseppina Sandri, Simona Motta, Maria Cristina Bonferoni, Paola Brocca, Silvia Rossi, Franca Ferrari, Valeria Rondelli, Laura Cantù, Carla Caramella, Elena Del Favero
Solid Lipid Nanoparticles (SLNs) composed of biodegradable physiological lipids have been widely proposed as efficient drug delivery systems, also for ophthalmic administration. Recently, chitosan-associated-SLNs have been developed to further improve the residence time of these colloidal systems in the precorneal area by means of mucoadhesive interaction. In the present study, a one-step preparation protocol was used aiming both at scale-up ease and at stronger coupling between chitosan and SLNs. The resulting particles were chitosan associated-SLNs (CS-SLNs)...
January 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27983789/feasibility-of-spatially-offset-raman-spectroscopy-for-in-vitro-and-in-vivo-monitoring-mineralization-of-bone-tissue-engineering-scaffolds
#17
Zhiyu Liao, Faris Sinjab, Amy Nommeots-Nomm, Julian Jones, Laura Ruiz-Cantu, Jing Yang, Felicity Rose, Ioan Notingher
We investigated the feasibility of using spatially offset Raman spectroscopy (SORS) for nondestructive characterization of bone tissue engineering scaffolds. The deep regions of these scaffolds, or scaffolds implanted subcutaneously in live animals, are typically difficult to measure by confocal Raman spectroscopy techniques because of the limited depth penetration of light caused by the high level of light scattering. Layered samples consisting of bioactive glass foams (IEIC16), three-dimensional (3D)-printed biodegradable poly(lactic-co-glycolic acid) scaffolds (PLGA), and hydroxyapatite powder (HA) were used to mimic nondestructive detection of biomineralization for intact real-size 3D tissue engineering constructs...
December 16, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27979133/isolation-and-characterization-of-a-xylan-with-industrial-and-biomedical-applications-from-edible-a%C3%A3-a%C3%A3-berries-euterpe-oleraceae
#18
Thaisa Moro Cantu-Jungles, Marcello Iacomini, Thales R Cipriani, Lucimara M C Cordeiro
The chemical features of xylan largely determine its physical and biological properties and its use in the industry. In this work, we describe the occurrence, purification and partial characterization of a xylan in edible açaí berries (Euterpe oleraceae), using a fairly simple and inexpensive method of purification from alkaline açaí extract. A mainly linear (1→4)-β-d-xylan was found as the majority (70%) of alkali extract and 4.2% of the dry matter açaí pulp. This represents the biggest source of xylan found so far in a fruit pulp and could be suitable for applications in the industry and biomedical field...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27973805/substrate-sulfoxidation-by-an-iron-iv-oxo-complex-benchmarking-computationally-calculated-barrier-heights-to-experiment
#19
Fabián G Cantú Reinhard, Abayomi S Faponle, Sam P de Visser
High-valent metal-oxo oxidants are common reactive species in synthetic catalysts as well as heme and nonheme iron enzymes. In general, they efficiently react with substrates through oxygen atom transfer, and for a number of cases, experimental rate constants have been determined. However, because these rate constants are generally measured in a polar solution, it has been found difficult to find computational methodologies to reproduce experimental trends and reactivities. In this work, we present a detailed computational study into para-substituted thioanisole sulfoxidation by a nonheme iron(IV)-oxo complex...
December 15, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27958762/cd47-and-nox1-mediate-dynamic-fluid-phase-macropinocytosis-of-native-ldl
#20
Gabor Csanyi, Douglas M Feck, Pushpankur Ghoshal, Bhupesh Singla, Hui-Ping Lin, Shanmugam Nagarajan, Daniel N Meijles, Imad Al Ghouleh, Nadiezhda Cantu-Medellin Cantu-Medellin, Eric E Kelley, Lukasz Mateuszuk Mateuszuk, Jeffrey S Isenberg, Simon C Watkins, Patrick J Pagano
AIMS: Macropinocytosis has been implicated in cardiovascular and other disorders yet the physiological factors that initiate fluid-phase internalization and the signaling mechanisms involved remain poorly identified. The present study was designed to examine whether matrix protein thrombospondin-1 (TSP1) stimulates macrophage macropinocytosis and, if so, to investigate the potential signaling mechanism involved. RESULTS: TSP1 treatment of human and murine macrophages stimulated membrane ruffle formation and pericellular solute internalization by macropinocytosis...
December 13, 2016: Antioxidants & Redox Signaling
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