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https://www.readbyqxmd.com/read/28218439/the-effects-of-exogenous-fatty-acids-and-niacin-on-human-monocyte-macrophage-plasticity
#1
Sergio Montserrat-de la Paz, Dolores Rodriguez, Magdalena P Cardelo, Maria C Naranjo, Beatriz Bermudez, Rocio Abia, Francisco J G Muriana, Sergio Lopez
SCOPE: Macrophage plasticity allows adapting to different environments, having a dual activity in inflammatory-related diseases. Our hypothesis is that the type of dietary fatty acids into human postprandial triglyceride-rich lipoproteins (TRLs), alone or in combination with niacin (vitamin B3), could modulate the plasticity of monocytes-macrophages. METHODS AND RESULTS: We isolated TRLs at the postprandial peak from blood samples of healthy volunteers after the ingestion of a meal rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) or MUFAs plus omega-3 long-chain polyunsaturated fatty acids (LCPUFAs)...
February 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28210960/first-description-of-the-male-and-redescription-of-the-female-of-ixodes-tapirus-kohls-1956-acari-ixodidae-a-parasite-of-tapirs-perissodactyla-tapiridae-from-the-mountains-of-colombia-costa-rica-and-panama
#2
Dmitry A Apanaskevich, Lillian G Domínguez, Sugeys S Torres, Juan A Bernal, Victor M Montenegro, Sergio E Bermúdez
The male of Ixodes tapirus Kohls, 1956 (Acari: Ixodidae) is described for the first time and the female is redescribed in greater detail. Adults of I. tapirus are similar to those of Ixodes guatemalensis Kohls, 1956, Ixodes lasallei Méndez & Ortiz, 1958, Ixodes montoyanus Cooley, 1944 and Ixodes venezuelensis Kohls, 1953 but can be distinguished by their overall size, the amount of sclerotisation of the conscutum and accessory plates, the shape of the scutum, the number of punctations and their pattern on the conscutum and scutum, the depth of the punctations on the basis capituli dorsally, the shape and size of the porose areas and the size and shape of the auriculae...
February 15, 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28206936/independent-preoperative-predictors-of-prolonged-length-of-stay-after-laparoscopic-appendectomy-in-patients-over-30-years-of-age-experience-from-a-single-institution
#3
Eric S Wise, Stephen P Gadomski, Annette M Ilg, Camilo Bermudez, Emily W Chan, Michelle L Izmaylov, Samantha J Gridley, Jessica V Kaczmarek, Sir Norman T Melancon, Sarwat Ahmad, Kyle M Hocking, Jose J Diaz, Stephen M Kavic
Prompt discharge after laparoscopic appendectomy (LA) is a marker of quality of care, fiscally desirable and feasible in select patients. Patients over 30 comprise a more heterogeneous cohort known to experience worse outcomes after LA. We aimed to identify easily available preoperative risk factors portending a postoperative length of stay ≥2 days among patients above age 30. In this investigation, 296 included patients from a single institution who underwent LA for acute appendicitis from 2010 to 2014 were retrospectively reviewed for preoperative demographics, laboratory studies, comorbidities, presentation characteristics, radiographic finding, and other rationally selected factors for association with postoperative length of stay ≥2 days...
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28199111/parallel-comparison-of-n-linked-glycopeptide-enrichment-techniques-reveals-extensive-glycoproteomic-analysis-of-plasma-enabled-by-sax-erlic
#4
Sarah M Totten, Christa L Feasley, Abel Bermudez, Sharon J Pitteri
Protein glycosylation is of increasing interest due to its important roles in protein function and aberrant expression with disease. Characterizing protein glycosylation remains analytically challenging due to its low abundance, ion suppression issues, and microheterogeneity at glycosylation sites, especially in complex samples such as human plasma. In this study, the utility of three common N-linked glycopeptide enrichment techniques is compared using human plasma. By analysis on an LTQ-Orbitrap Elite mass spectrometer, electrostatic repulsion hydrophilic interaction liquid chromatography using strong anion exchange solid-phase extraction (SAX-ERLIC) provided the most extensive N-linked glycopeptide enrichment when compared with multilectin affinity chromatography (M-LAC) and Sepharose-HILIC enrichments...
February 15, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28196664/new-records-of-ornithodoros-puertoricensis-fox-1947-ixodida-argasidae-parasitizing-humans-in-rural-and-urban-dwellings-panama
#5
Sergio E Bermúdez, Eduardo Castillo, Tyler D Pohlenz, Alexander Kneubehl, Aparna Krishnavajhala, Lillian Domínguez, Antonio Suárez, Job E López
The presence of ticks inside human constructions was evaluated in two localities from Colon province (Charco La Piedra and Espinar) and one from Panama province (Ancon, City of Panama). In two of houses, eight people from Charco La Piedra and one from Ancón reported "insect bites," which produced blisters for several weeks. The investigation resulted in the collection of argasid ticks, which were identified by morphology and sequencing the 16s ribosomal RNA gene, and later evaluated for the presence of relapsing fever Borrelia DNA...
February 5, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28193209/secretion-of-biologically-active-pancreatitis-associated-protein-i-pap-by-genetically-modified-dairy-lactococcus-lactis-nz9000-in-the-prevention-of-intestinal-mucositis
#6
Rodrigo D Carvalho, Natalia Breyner, Zelia Menezes-Garcia, Nubia M Rodrigues, Luisa Lemos, Tatiane U Maioli, Danielle da Gloria Souza, Denise Carmona, Ana M C de Faria, Philippe Langella, Jean-Marc Chatel, Luis G Bermúdez-Humarán, Henrique C P Figueiredo, Vasco Azevedo, Marcela S de Azevedo
BACKGROUND: Mucositis is one of the most relevant gastrointestinal inflammatory conditions in humans, generated by the use of chemotherapy drugs, such as 5-fluoracil (5-FU). 5-FU-induced mucositis affects 80% of patients undergoing oncological treatment causing mucosal gut dysfunctions and great discomfort. As current therapy drugs presents limitations in alleviating mucositis symptoms, alternative strategies are being pursued. Recent studies have shown that the antimicrobial pancreatitis-associated protein (PAP) has a protective role in intestinal inflammatory processes...
February 13, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28191300/a-case-report-of-neisseria-mucosa-peritonitis-in-a-chronic-ambulatory-peritoneal-dialysis-patient
#7
Alan Awdisho, Maria Bermudez
Peritonitis is a leading complication of chronic ambulatory peritoneal dialysis. However, very rarely does Neisseria mucosa cause peritonitis. We describe an unusual case of N. mucosa peritonitis in a chronic ambulatory peritoneal dialysis patient. A 28-year-old Hispanic male presents with diffuse abdominal pain exacerbated during draining of the peritoneal fluid. Peritoneal fluid examination was remarkable for leukocytosis and gramnegative diplococci. Bacterial cultures were positive for N. mucosa growth. The patient was treated with ciprofloxacin with preservation of the dialysis catheter...
December 31, 2016: Infectious Disease Reports
https://www.readbyqxmd.com/read/28177056/social-representations-of-the-health-care-of-the-mby%C3%A3-guarani-indigenous-population-by-health-workers
#8
Mirian Benites Falkenberg, Helena Eri Shimizu, Ximena Pamela Díaz Bermudez
Objective: to analyze the social representations of health care of the Mbyá-Guarani ethnic group by multidisciplinary teams from the Special Indigenous Health District in the south coast of Rio Grande do Sul state (Distrito Sanitário Especial Indígena Litoral Sul do Rio Grande do Sul), Brazil. Method: a qualitative method based on the theory of social representations was used. Data were collected via semi-structured interviews with 20 health workers and by participant observation...
February 6, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28176408/hippocampal-release-of-dopamine-and-norepinephrine-encodes-novel-contextual-information
#9
Perla Moreno-Castilla, Rodrigo Pérez-Ortega, Valeria Violante-Soria, Israela Balderas, Federico Bermúdez-Rattoni
The detection and processing of novel information encountered in our environment is crucial for proper adaptive behavior and learning. Hippocampus is a prime structure for novelty detection that receives high-level inputs including context information. It is of our interest to understand the mechanisms by which the hippocampus processes contextual information. For this, we performed in vivo microdyalisis in order to monitor extracellular changes in neurotransmitter levels during Object Location Memory (OLM), a behavioral protocol developed to evaluate contextual information processing in recognition memory...
February 8, 2017: Hippocampus
https://www.readbyqxmd.com/read/28174624/sex-differences-in-the-aging-pattern-of-renin-angiotensin-system-serum-peptidases
#10
A Fernández-Atucha, A Izagirre, A B Fraile-Bermúdez, M Kortajarena, G Larrinaga, P Martinez-Lage, E Echevarría, J Gil
BACKGROUND: Serum peptidases, such as angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (ACE2), neutral endopeptidase (NEP), aminopeptidase N (APN), and aminopeptidase A (APA), are important elements of the renin-angiotensin system (RAS). Dysregulation of these enzymes has been associated with hypertension and cardiovascular risk. In the present study, serum activities of RAS peptidases were analyzed to evaluate the existence of sexual differences, with a possible different pattern in pre- and post-andropausal/post-menopausal participants...
2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/28169401/giardia-duodenalis-rad52-protein-biochemical-characterization-and-response-upon-dna-damage
#11
Rosa María Martínez Miguel, Antonio Sandoval Cabrera, María Luisa Bazán-Tejeda, Ana Laura Torres Huerta, Diego A Martínez Reyes, Rosa María Bermúdez Cruz
No abstract text is available yet for this article.
February 7, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28168879/head-and-neck-squamous-cell-carcinoma-metabolism-draws-on-glutaminolysis-and-stemness-is-specifically-regulated-by-glutaminolysis-via-aldehyde-dehydrogenase
#12
Pachiyappan Kamarajan, Thekkelnaycke M Rajendiran, Jason Kinchen, Mercedes Bermúdez, Theodora Danciu, Yvonne Lorraine Kapila
Cancer cells use alternate energetic pathways, however cancer stem cell (CSC) metabolic energetic pathways are unknown. The purpose of this study was to define the metabolic characteristics of head and neck cancer at different points of its pathogenesis with a focus on its CSC compartment. UPLC-MS/MS-profiling and GC-MS-validation studies of human head and neck cancer tissue, saliva, and plasma, were used in conjunction with in vitro and in vivo models to carry out this investigation. We identified metabolite biomarker panels that distinguish head and neck cancer from healthy controls, and confirmed involvement of glutamate and glutaminolysis...
February 7, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28168862/increased-systemic-cytokine-chemokine-expression-in-asthmatic-and-non-asthmatic-patients-with-bacterial-viral-or-mixed-lung-infection
#13
Maria J Giuffrida, Nereida Valero, Jesus Mosquera, Anyelo Duran, Francisco Arocha, Betulio Chacín, Luz Marina Espina, Jenifer Gotera, John Bermudez, Alibeth Mavarez, Melchor Alvarez-Mon
This study was aimed to determine the profiles of serum cytokines (IL-1β, TNF-α, IL-4, IL-5) and chemokines (MCP-1: monocyte chemoattract protein-1 and RANTES: regulated on activation normal T cell expressed and secreted) in individuals with an asthmatic versus a non-asthmatic background with bacterial, viral or mixed acute respiratory infection. Asthmatic (n=14) and non- asthmatic (n=29) patients with acute viral, bacterial or mixed (bacterial and viruses) respiratory infection were studied. Patients were also analyzed as individuals with pneumonia or bronchitis...
February 7, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28154242/efficient-and-stable-solution-processed-planar-perovskite-solar-cells-via-contact-passivation
#14
Hairen Tan, Ankit Jain, Oleksandr Voznyy, Xinzheng Lan, F Pelayo García de Arquer, James Z Fan, Rafael Quintero-Bermudez, Mingjian Yuan, Bo Zhang, Yicheng Zhao, Fengjia Fan, Peicheng Li, Li Na Quan, Yongbiao Zhao, Zheng-Hong Lu, Zhenyu Yang, Sjoerd Hoogland, Edward H Sargent
Planar perovskite solar cells made entirely via solution-processing at low temperatures (<150°C) offer promise for simple manufacturing, compatibility with flexible substrates, and perovskite-based tandem devices; however, they require an electron-selective layer that performs well with similar processing. We report a contact passivation strategy using chlorine-capped TiO2 colloidal nanocrystal (NC) film that mitigates interfacial recombination and improves interface binding in low-temperature planar solar cells...
February 2, 2017: Science
https://www.readbyqxmd.com/read/28153714/validation-of-two-point-of-care-tests-against-standard-lab-measures-of-no-in-saliva-and-in-serum
#15
Ashwin Modi, Evangelia Morou-Bermudez, Jose Vergara, Rakesh Patel, Alexandria Nichols, Kaumudi Joshipura
No abstract text is available yet for this article.
January 30, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28149479/prophylaxis-and-antibiotic-therapy-in-management-protocols-of-patients-treated-with-oral-and-intravenous-bisphosphonates
#16
REVIEW
Elena-Beatriz Bermúdez-Bejarano, María-Ángeles Serrera-Figallo, Aida Gutiérrez-Corrales, Manuel-María Romero-Ruiz, Raquel Castillo-de-Oyagüe, José-Luis Gutiérrez-Pérez, Daniel Torres-Lagares
INTRODUCTION: Osteonecrosis of the jaw (MRONJ) linked to bisphosphonate treatment has specific characteristics that render its therapeutic management challenging for clinicians. Poor response to standard treatment makes it essential to take special precautions when treating this type of disease; therefore, antibiotic prophylaxis and/or antibiotic therapy have been proposed as effective and helpful tools in these situations. OBJECTIVES: This article seeks to assess published evidence in order to evaluate the different protocols used for antibiotic prophylaxis and/or antibiotic therapy in the general context of patients treated with bisphosphonates...
January 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28132422/probing-the-biology-of-cell-boundary-conditions-through-confinement-of-xenopus-cell-free-cytoplasmic-extracts
#17
REVIEW
Jessica G Bermudez, Hui Chen, Lily C Einstein, Matthew C Good
Cell-free cytoplasmic extracts prepared from Xenopus eggs and embryos have for decades provided a biochemical system with which to interrogate complex cell biological processes in vitro. Recently, the application of microfabrication and microfluidic strategies in biology has narrowed the gap between in vitro and in vivo studies by enabling formation of cell-size compartments containing functional cytoplasm. These approaches provide numerous advantages over traditional biochemical experiments performed in a test tube...
January 2017: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/28131982/use-of-5-azacitidine-for-therapy-related-myeloid-neoplasms-in-patients-with-concomitant-active-neoplastic-disease
#18
M Annereau, C Willekens, L El Halabi, C Chahine, V Saada, N Auger, A Danu, E Bermudez, J Lazarovici, D Ghez, A Leary, B Pistilli, F Lemare, E Solary, S de Botton, R-P Desmaris, J-B Micol
BACKGROUND: Patients diagnosed with therapy-related myeloid neoplasms (TRMN) with concomitant active neoplastic disorder (CAND) are usually proposed for best supportive care (BSC). We evaluated the feasibility of using 5-azacytidine (AZA) in this setting. METHODS: All patients referred to Gustave Roussy between 2010 and 2015 for TRMN diagnosis (less than 30% blast) and eligible for AZA treatment were included. Patients with CAND proposed for BSC were also described...
January 20, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28131190/comorbid-conditions-associated-with-parkinson-s-disease-a-longitudinal-and-comparative-study-with-alzheimer-disease-and-control-subjects
#19
D Santos García, E Suárez Castro, I Expósito, T de Deus, C Tuñas, A Aneiros, M López Fernández, D Núñez Arias, M Bermúdez Torres
BACKGROUND AND OBJECTIVE: To study what comorbid conditions were present at baseline and 3years later in a cohort of Spanish Parkinson's disease (PD) patients, to compare comorbidity with both Alzheimer's disease (AD) and control groups and to analyze the role of comorbidity as predictor of mortality. METHODS: One hundred and forty-seven non-demented PD patients (57.1% males; 70.9±8.6years old) were included in this 36months follow-up (2012-2015), monocenter, evaluation study...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28129297/toxic-anterior-segment-syndrome-inadvertent-administration-of-intracameral-lidocaine-1-and-phenylephrine-2-5-preserved-with-10-benzalkonium-chloride-during-cataract-surgery
#20
Brett P Bielory, Ayesha Shariff, Rehan M Hussain, Jose Antonio Bermudez-Magner, Sander R Dubovy, Kendall E Donaldson
PURPOSE: To report 3 patients with corneal decompensation and anterior uveitis within 24 hours of cataract surgery from a single ambulatory surgery center using intracameral lidocaine HCl 1% and phenylephrine 2.5% inadvertently preserved with 10% benzalkonium chloride. METHODS: This case series describes 3 patients who underwent traditional cataract extraction with a significant decrease in visual acuity in the immediate postoperative period resulting in secondary surgical intervention for corneal decompensation in 2 patients...
January 26, 2017: Cornea
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