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https://www.readbyqxmd.com/read/28429461/deodorization-of-arthrospira-platensis-biomass-for-further-scale-up-food-applications
#1
Sara P Cuellar-Bermúdez, Bertha Barba-Davila, Sergio O Serna-Saldivar, Roberto Parra-Saldivar, José Rodriguez-Rodriguez, Sandra Morales-Davila, Koen Goiris, Koenraad Muylaert, Cristina Chuck-Hernández
BACKGROUND: Given the importance of A. platensis as a potential food protein source, we achieve an affordable deodorization process that does not significantly affect the nutritional value of algae biomass. RESULTS: Ethanol, acetone or hexane were used to deodorize algae biomass and then to identify the profile of volatile compounds associated with its distinctive odor. Sensorial characteristics were improved in the biomass cake after the proposed solvent extraction...
April 21, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28417248/ticks-and-tick-borne-pathogens-of-dogs-along-an-elevational-and-land-use-gradient-in-chiriqu%C3%A3-province-panam%C3%A3
#2
A Michelle Ferrell, R Jory Brinkerhoff, Juan Bernal, Sergio E Bermúdez
Systematic acarological surveys are useful tools in assessing risk to tick-borne infections, especially in areas where consistent clinical surveillance for tick-borne disease is lacking. Our goal was to identify environmental predictors of tick burdens on dogs and tick-borne infectious agents in dog-derived ticks in the Chiriquí Province of western Panama to draw inferences about spatio-temporal variation in human risk to tick-borne diseases. We used a model-selection approach to test the relative importance of elevation, human population size, vegetative cover, and change in landuse on patterns of tick parasitism on dogs...
April 17, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28416555/mycobacterium-tuberculosis-proteome-response-to-anti-tuberculosis-compounds-reveals-metabolic-escape-pathways-that-prolong-bacterial-survival
#3
Lia Danelishvili, Natalia Shulzhenko, Jessica J J Chinison, Lmar Babrak, Jialu Hu, Andriy Morgun, Gregory Burrows, Luiz E Bermudez
Tuberculosis (TB) continues to be one of the most common bacterial infectious diseases and the leading cause of death in many parts of the world. A major limitation of TB therapy is slow killing of infecting organism, increasing the risk for the development of tolerance phenotype and drug-resistance. Studies indicate that M. tuberculosis (Mtb) takes several days to be killed upon treatment with lethal concentrations of antibiotics both in vitro and in vivo To investigate how metabolic remodeling can enable transient bacterial survival during exposure with bactericidal concentrations of compounds, Mtb H37Rv strain was exposed to twice of the minimal inhibitory concentration of isoniazid, rifampicin, moxifloxacin, mefloquine or bedaquiline for 24h, 48h, 4 days, and 6 days, and the bacterial proteomic response was analyzed using the quantitative shotgun mass spectrometry...
April 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28414293/inherited-gins1-deficiency-underlies-growth-retardation-along-with-neutropenia-and-nk-cell-deficiency
#4
Julien Cottineau, Molly C Kottemann, Francis P Lach, Young-Hoon Kang, Frédéric Vély, Elissa K Deenick, Tomi Lazarov, Laure Gineau, Yi Wang, Andrea Farina, Marie Chansel, Lazaro Lorenzo, Christelle Piperoglou, Cindy S Ma, Patrick Nitschke, Aziz Belkadi, Yuval Itan, Bertrand Boisson, Fabienne Jabot-Hanin, Capucine Picard, Jacinta Bustamante, Céline Eidenschenk, Soraya Boucherit, Nathalie Aladjidi, Didier Lacombe, Pascal Barat, Waseem Qasim, Jane A Hurst, Andrew J Pollard, Holm H Uhlig, Claire Fieschi, Jean Michon, Vladimir P Bermudez, Laurent Abel, Jean-Pierre de Villartay, Frédéric Geissmann, Stuart G Tangye, Jerard Hurwitz, Eric Vivier, Jean-Laurent Casanova, Agata Smogorzewska, Emmanuelle Jouanguy
Inborn errors of DNA repair or replication underlie a variety of clinical phenotypes. We studied 5 patients from 4 kindreds, all of whom displayed intrauterine growth retardation, chronic neutropenia, and NK cell deficiency. Four of the 5 patients also had postnatal growth retardation. The association of neutropenia and NK cell deficiency, which is unusual among primary immunodeficiencies and bone marrow failures, was due to a blockade in the bone marrow and was mildly symptomatic. We discovered compound heterozygous rare mutations in Go-Ichi-Ni-San (GINS) complex subunit 1 (GINS1, also known as PSF1) in the 5 patients...
April 17, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28408371/leukocyte-overexpression-of-intracellular-nampt-attenuates-atherosclerosis-by-regulating-ppar%C3%AE-dependent-monocyte-differentiation-and-function
#5
Beatriz Bermudez, Tuva B Dahl, Indira Medina, Mathijs Groeneweg, Sverre Holm, Sergio Montserrat-de la Paz, Mat Rousch, Jeroen J T Otten, Veronica Herias, Lourdes M Varela, Trine Ranheim, Arne Yndestad, Almudena Ortega-Gomez, Rocio Abia, Laszlo Nagy, Pal Aukrust, Francisco J G Muriana, Bente Halvorsen, Erik A L Biessen
OBJECTIVE: Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) mediates inflammatory and potentially proatherogenic effects, whereas the role of intracellular NAMPT (iNAMPT), the rate limiting enzyme in the salvage pathway of nicotinamide adenine dinucleotide (NAD)(+) generation, in atherogenesis is largely unknown. Here we investigated the effects of iNAMPT overexpression in leukocytes on inflammation and atherosclerosis. APPROACH AND RESULTS: Low-density lipoprotein receptor-deficient mice with hematopoietic overexpression of human iNAMPT (iNAMPT(hi)), on a western type diet, showed attenuated plaque burden with features of lesion stabilization...
April 13, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28405229/epidemiologic-burden-of-hospitalisation-for-congestive-heart-failure-among-adults-aged-%C3%A2-19%C3%A2-years-in-the-philippines
#6
Bernadette A Tumanan-Mendoza, Victor L Mendoza, April Ann A Bermudez-Delos Santos, Felix Eduardo R Punzalan, Noemi S Pestaño, Rudy Boy Natividad, Louie Alfred Shiu, Renelene Macabeo
OBJECTIVES: The study determined the prevalence of hospitalisation due to congestive heart failure (CHF) among adult patients aged 19 years and above in the Philippines and its 17 regions in 2014. It also determined the demographic profile of these patients, aetiology and type of CHF, comorbidities, duration of hospitalisation and the overall in-hospital mortality rate. METHODS: Data collection was done using the hospitalisation claims database of the Philippine Health Insurance Corporation (PhilHealth)...
2017: Heart Asia
https://www.readbyqxmd.com/read/28402990/the-use-of-gmp-produced-bone-marrow-derived-stem-cells-in-combination-with-extra-corporeal-membrane-oxygenation-in-ards-an-animal-model
#7
Ergin Kocyildirim, Nayra Cárdenes, Antony Ting, Eder Cáceres, Christian Bermúdez, Mauricio Rojas
RDS is the result of a wide variety of disorders, which can be associated with different clinical disorders or systemic diseases directly affecting the lungs. Currently, the only existing therapy is limited to supportive care. In a 6-hour pilot study, we analyzed the use of the combination of both stem cell and ECMO strategies to prevent or treat severe lung injury. A total of 11 sheep were used. 5 sheep received E. coli endotoxin as a control group (Group 1). 3 sheep that received E. coli endotoxin were treated with veno-venous ECMO support in Group 2...
April 11, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28396353/the-histidine-residue-of-qsec-is-required-for-canonical-signaling-between-qseb-and-pmrb-in-uropathogenic-escherichia-coli
#8
Erin J Breland, Ellisa W Zhang, Tomas Bermudez, Charles R Martinez, Maria Hadjifrangiskou
Two-component systems are prototypically comprised of a histidine kinase (sensor) and a response regulator (responder). The sensor kinases auto-phosphorylate at a conserved histidine residue, acting as a phospho-donor for subsequent phosphotransfer to and activation of a cognate response regulator. In rare cases, the histidine residue is also essential for response regulator de-phosphorylation via a reverse-phosphotransfer reaction. In this work, we present an example of a kinase that relies on reverse-phosphotransfer to catalyze the de-phosphorylation of its cognate partner...
April 10, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28396076/assessment-of-port-sustainability-through-synthetic-indexes-application-to-the-spanish-case
#9
Fernando González Laxe, Federico Martín Bermúdez, Federico Martín Palmero, Isabel Novo-Corti
In general, Synthetic Indexes of sustainability have been applied to specific countries and regions. With some variations, the ones considered simple, such as the case of the Ecological Footprint (EF), have been applied to port areas. The same has not happened with those of a multidimensional nature (Global Synthetics) that still have a minimal and partial presence in the analysis of port sustainability. Understanding that this type of index represents an interesting and novel avenue of research applied to port systems, this contribution analyses and ranks a sample of 16 Spanish Port Authorities that group 23 ports of general interest using a Global Synthetic Index of Sustainability (developed using the four dimensions of sustainable development: economic, institutional, environmental and social)...
April 8, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28385183/vitamin-d-receptor-gene-polymorphisms-are-associated-with-multiple-sclerosis-in-mexican-adults
#10
Víctor Hugo Bermúdez-Morales, Geny Fierros, Roberto Lopez Lopez, Gaby Martínez-Nava, Mario Flores-Aldana, José Flores-Rivera, Carlos Hernández-Girón
BACKGROUND: Multiple sclerosis (MS) is the most prevalent autoimmune inflammatory demyelinating disease of the central nervous system (CNS) in young adults. More than 50 genomic regions have been associated with MS susceptibility. Due the important immune-modulating properties of Vitamin D, Vitamin D receptor (VDR) gene polymorphisms - which interfere with the actions of Vitamin D- could be related to increased risk of MS. METHODS: We studied 120 patients fulfilling the McDonald criteria for MS (81 females and 39 males) and 180 healthy unrelated controls, nested in a case-Control study, and were recruited from the National Institute of Neurology and Neurosurgery, Manuel Velasco Suárez in Mexico City...
May 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28375611/phase-transition-dielectric-properties-and-ionic-transport-in-the-ch3-2nh2-pbi3-organic-inorganic-hybrid-with-2h-hexagonal-perovskite-structure
#11
A García-Fernández, J M Bermúdez-García, S Castro-García, A L Llamas-Saiz, R Artiaga, J López-Beceiro, S Hu, W Ren, A Stroppa, M Sánchez-Andújar, M A Señarís-Rodríguez
In this work, we focus on [(CH3)2NH2]PbI3, a member of the [AmineH]PbI3 series of hybrid organic-inorganic compounds, reporting a very easy mechanosynthesis route for its preparation at room temperature. We report that this [(CH3)2NH2]PbI3 compound with 2H-perovskite structure experiences a first-order transition at ≈250 K from hexagonal symmetry P63/mmc (HT phase) to monoclinic symmetry P21/c (LT phase), which involves two cooperative processes: an off-center shift of the Pb(2+) cations and an order-disorder process of the N atoms of the DMA cations...
April 4, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28375341/stent-optical-inspection-system-calibration-and-performance
#12
Carlos Bermudez, Ferran Laguarta, Cristina Cadevall, Aitor Matilla, Sergi Ibañez, Roger Artigas
Implantable medical devices, such as stents, have to be inspected 100% so no defective ones are implanted into a human body. In this paper, a novel optical stent inspection system is presented. By the combination of a high numerical aperture microscope, a triple illumination system, a rotational stage, and a CMOS camera, unrolled sections of the outer and inner surfaces of the stent are obtained with high resolution at high speed with a line-scan approach. In this paper, a comparison between the conventional microscope image formation and this new approach is shown...
March 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28372159/a-sequential-determination-of-90-sr-and-210-po-in-food-samples
#13
S Hurtado-Bermudez, J L Mas, M Villa-Alfageme
The latest EU Council Regulation 2016/52/Euratom updates the emergency limits on radionuclides in foods including (210)Po and (90)Sr, two of the most important radionuclides for radiological dose from the ingestion pathway. A novel and straightforward method has been developed for sequential determination of (90)Sr and (210)Po in food samples using ultra low-level liquid scintillation counting and alpha-particle spectrometry. For (90)Sr analysis, the method makes use of stable strontium as yield tracer, and (210)Po is determined through self-deposition using (209)Po as a yield tracer...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28370565/highly-emissive-green-perovskite-nanocrystals-in-a-solid-state-crystalline-matrix
#14
Li Na Quan, Rafael Quintero-Bermudez, Oleksandr Voznyy, Grant Walters, Ankit Jain, James Zhangming Fan, Xueli Zheng, Zhenyu Yang, Edward H Sargent
Perovskite nanocrystals (NCs) have attracted attention due to their high photoluminescence quantum yield (PLQY) in solution; however, maintaining high emission efficiency in the solid state remains a challenge. This study presents a solution-phase synthesis of efficient green-emitting perovskite NCs (CsPbBr3 ) embedded in robust and air-stable rhombic prism hexabromide (Cs4 PbBr6 ) microcrystals, reaching a PLQY of 90%. Theoretical modeling and experimental characterization suggest that lattice matching between the NCs and the matrix contribute to improved passivation, while spatial confinement enhances the radiative rate of the NCs...
March 29, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28370133/isobolographic-analyses-of-proglumide-celecoxib-interaction-in-rats-with-painful-diabetic-neuropathy
#15
Samuel Suarez-Mendez, Carlos A Tovilla-Zarate, Luis F Ortega-Varela, Deysi Y Bermudez-Ocaña, Jorge L Blé-Castillo, Thelma B González-Castro, Alma M Zetina-Esquivel, Juan C Diaz-Zagoya, Isela Esther Juárez-Rojop
Preclinical Research The aim of the present study was to analyze the antihyperalgesic and antiallodynic interaction between the non-selective cholecystokinin (CCK) antagonist receptor, proglumide, and the selective cyclooxygenase-2 inhibitor, celecoxib in streptozotocin (STZ)-induced diabetic rats. Hyperalgesia was evaluated in the formalin test and tactile allodynia using von Frey filaments. Isobolographic analyses were employed to define the nature of the compound interactions, using a fixed dose ratio (0...
April 3, 2017: Drug Development Research
https://www.readbyqxmd.com/read/28369662/early-pleistocene-hominin-deciduous-teeth-from-the-homo-antecessor-gran-dolina-td6-bearing-level-sierra-de-atapuerca-spain
#16
José María Bermúdez de Castro, María Martinón-Torres, Laura Martín-Francés, Marina Martínez de Pinillos, Mario Modesto-Mata, Cecilia García-Campos, Xiujie Wu, Song Xing, Wu Liu
OBJECTIVES: During the last 13 years, the late Early Pleistocene Gran Dolina-TD6-2 level (Sierra de Atapuerca, northern Spain) has yielded an additional sample of 26 dental specimens attributed to Homo antecessor. In this report, we present a descriptive and comparative study of the six deciduous teeth. METHODS: We provide external and internal morphological descriptions following classical terminology, as well as the mesiodistal and buccolingual measurements of the teeth...
March 31, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28366202/human-predatory-behavior-and-the-social-implications-of-communal-hunting-based-on-evidence-from-the-td10-2-bison-bone-bed-at-gran-dolina-atapuerca-spain
#17
Antonio Rodríguez-Hidalgo, Palmira Saladié, Andreu Ollé, Juan Luis Arsuaga, José María Bermúdez de Castro, Eudald Carbonell
Zooarcheological research is an important tool in reconstructing subsistence, as well as for inferring relevant aspects regarding social behavior in the past. The organization of hunting parties, forms of predation (number and rate of animals slaughtered), and the technology used (tactics and tools) must be taken into account in the identification and classification of hunting methods in prehistory. The archeological recognition of communal hunting reflects an interest in evolutionary terms and their inherent implications for anticipatory capacities, social complexity, and the development of cognitive tools, such as articulated language...
April 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28361526/ceftolozane-tazobactam-for-the-treatment-of-ventilator-associated-infections-by-colistin-resistant-pseudomonas-aeruginosa
#18
F Álvarez Lerma, R Muñoz Bermudez, S Grau, M P Gracia Arnillas, L Sorli, L Recasens, M Mico García
The use of colistin for the treatment of multiresistant bacteria has led to the emergence of colistin-resistant strains of Gram-negative bacilli. Treatment of infections caused by these pan-drug-resistant bacteria is difficult owing to the paucity of effective antibiotics. We report two cases of ventilator-associated respiratory infection caused by pan-drug-resistant, colistin-resistant Pseudomonas aeruginosa that were successfully treated with ceftolozane-tazobactam.
March 29, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28360217/bilateral-lung-transplantation-for-bleomycin-associated-lung-injury
#19
Vivek Narayan, Charuhas Deshpande, Christian A Bermudez, Jaclyn M Golato, James C Lee, Joshua Diamond, David J Vaughn
This report details the successful use of bilateral lung transplantation for the management of severe postoperative bleomycin-associated lung injury. This case highlights that the extremely favorable prognosis of advanced testicular germ cell tumors after systemic chemotherapy (>90% cure rate) should not preclude lung transplant consideration in all cases, despite current guidance that considers an advanced malignancy to be a contraindication for lung transplant listing. The Oncologist 2017;22:1-3.
March 30, 2017: Oncologist
https://www.readbyqxmd.com/read/28359376/living-without-lungs-bilateral-pneumonectomy-and-dual-circulatory-support-a-step-forward-in-the-search-for-a-total-artificial-lung
#20
EDITORIAL
Christian A Bermudez, Maria M Crespo
No abstract text is available yet for this article.
April 2017: Journal of Thoracic and Cardiovascular Surgery
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