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https://www.readbyqxmd.com/read/28097783/type-iii-pleuropulmonary-blastoma-in-a-dicer1-germline-mutation-carrier-the-management-of-residual-lung-cystic-lesions
#1
Ana M Fita, Esther Llinares-Riestra, Ernesto Doménech-Abellán, Mar Bermúdez-Cortés, Ana M Galera-Miñarro, Agueda Bas-Bernal, José L Fuster-Soler
Pleuropulmonary blastoma (PPB) is a rare malignancy of childhood. It often represents a manifestation of a hereditary tumor predisposition syndrome (DICER1 syndrome). Because of its malignant potential, surgical resection of cystic lung lesions is recommended in germline DICER1 mutation carriers. We present a case of a 3-year-old male child with type III PPB successfully managed with ifosfamide, vincristine, actinomycin-D, and doxorubicin (IVADo) chemotherapy and surgery. A heterozygous germline pR688X mutation of DICER1 gene was demonstrated...
January 18, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28097526/improved-measurement-of-elastic-properties-of-cells-by-micropipette-aspiration-and-its-application-to-lymphocytes
#2
Gustavo Esteban-Manzanares, Blanca González-Bermúdez, Julia Cruces, Mónica De la Fuente, Qingxuan Li, Gustavo V Guinea, José Pérez-Rigueiro, Manuel Elices, Gustavo R Plaza
Mechanical deformability of cells is an important property for their function and development, as well as a useful marker of cell state. The classical technique of micropipette aspiration allows single-cell studies and we provide here a method to measure the two basic mechanical parameters, elastic modulus and Poisson's ratio. The proposed method, developed from finite-element analysis of micropipette aspiration experiments, may be implemented in future technologies for the automated measurement of mechanical properties of cells, based on the micropipette aspiration technique or on the cell transit through flow constrictions...
January 17, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28094025/mechanical-and-microbiological-properties-and-drug-release-modeling-of-an-etch-and-rinse-adhesive-containing-copper-nanoparticles
#3
M F Gutiérrez, P Malaquias, T P Matos, A Szesz, S Souza, J Bermudez, A Reis, A D Loguercio, P V Farago
OBJECTIVES: To evaluate the effect of addition of copper nanoparticles (CN) at different concentrations into a two-step etch-and-rinse (2-ER) adhesive on antimicrobial activity (AMA), copper release (CR), ultimate tensile strength (UTS), degree of conversion (DC), water sorption (WS), solubility (SO), as well as the immediate (IM) and 1-year resin-dentin bond strength (μTBS) and nanoleakage (NL). METHODS: Seven adhesives were formulated according to the addition of CN (0, 0...
January 13, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28086995/-evidence-based-public-health-in-gaceta-sanitaria-a-nod-to-latin-america
#4
EDITORIAL
Mercedes Carrasco-Portiño, Laura González Zapata, Leila Posenato García, Clara Bermúdez-Tamayo, Carlos Álvarez-Dardet
No abstract text is available yet for this article.
January 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28078169/a-survey-of-energy-drink-consumption-patterns-among-college-students-at-a-mostly-hispanic-university
#5
Ernesto Cabezas-Bou, Jeidiel De León-Arbucias, Nikol Matos-Vergara, Yocasta Álvarez-Bagnarol, Jesús Ortega-Guzmán, Karla Narváez-Pérez, Nelson D Cruz-Bermúdez, Manuel Díaz-Ríos
Background: The purpose of this study was to determine energy drink (ED) consumption patterns among Hispanic college students. We measured the prevalence and frequency of ED consumption according to gender, degree programs, and specific university-related and social situations. In addition, we assessed the frequency of consumption of EDs mixed with alcoholic beverages. Methods: A total of 508 college students from the University of Puerto Rico, the largest Hispanic institution of higher education statewide, completed an online questionnaire...
December 1, 2016: Journal of Caffeine Research
https://www.readbyqxmd.com/read/28077329/body-schema-plasticity-after-stroke-subjective-and-neurophysiological-correlates-of-the-rubber-hand-illusion
#6
Roberto Llorens, Adrián Borrego, Priscila Palomo, Ausiàs Cebolla, Enrique Noé, Sergi Bermúdez I Badia, Rosa Baños
Stroke can lead to motor impairments that can affect the body structure and restraint mobility. We hypothesize that brain lesions and their motor sequelae can distort the body schema, a sensorimotor map of body parts and elements in the peripersonal space through which human beings embody the reachable space and ready the body for forthcoming movements. Two main constructs have been identified in the embodiment mechanism: body-ownership, the sense that the body that one inhabits is his/her own, and agency, the sense that one can move and control his/her body...
January 8, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28076581/-social-determinants-of-health-and-convergence-in-health-agendas-of-regional-agencies-in-south-america
#7
Ximena Pamela Díaz-Bermúdez, Flavia Bueno, Luis Francisco Sánchez Otero, Annela Jean Auer
Objective: Characterize areas of interinstitutional cooperation and converging health agendas of the Pan American Health Organization/World Health Organization (PAHO/WHO), the Health Council of the Union of South American Nations (UNASUR), and the Amazon Cooperation Treaty Organization (ACTO) in South America based on social determinants of health. Methods: A qualitative study based on official documentary sources from the three organizations, using a comparative analysis of the health agendas of these agencies and the Rio Political Declaration on Social Determinants of Health (2011)...
November 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28073574/massive-donor-transfusion-potentially-increases-recipient-mortality-after-lung-transplantation
#8
Catherine F Borders, Yoshikazu Suzuki, Jared Lasky, Christian Schaufler, Djamila Mallem, James Lee, Kevin Carney, Scarlett L Bellamy, Christian A Bermudez, A Russell Localio, Jason D Christie, Joshua M Diamond, Edward Cantu
OBJECTIVE: Donor blood transfusion has been identified as a potential risk factor for primary graft dysfunction and by extension early mortality. We sought to define the contributing risk of donor transfusion on early mortality for lung transplant. METHODS: Donor and recipient data were abstracted from the Organ Procurement and Transplantation Network database updated through June 30, 2014, which included 86,398 potential donors and 16,255 transplants. Using the United Network for Organ Sharing 4-level designation of transfusion (no blood, 1-5 units, 6-10 units, and >10 units, massive), we analyzed all-cause mortality at 30-days with the use of logistic regression adjusted for confounders (ischemic time, donor age, recipient diagnosis, lung allocation score and recipient age, and recipient body mass index)...
December 15, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28068412/a-comparison-of-gene-expression-profiles-between-glucocorticoid-responder-and-non-responder-bovine-trabecular-meshwork-cells-using-rna-sequencing
#9
Jaclyn Y Bermudez, Hannah C Webber, Bartley Brown, Terry A Braun, Abbot F Clark, Weiming Mao
The most common ocular side effect of glucocorticoid (GC) therapy is GC-induced ocular hypertension (OHT) and GC-induced glaucoma (GIG). GC-induced OHT occurs in about 40% of the general population, while the other 60% are resistant. This study aims to determine the genes and pathways involved in differential GC responsiveness in the trabecular meshwork (TM). Using paired bovine eyes, one eye was perfusion-cultured with 100nM dexamethasone (DEX), while the fellow eye was used to establish a bovine TM (BTM) cell strain...
2017: PloS One
https://www.readbyqxmd.com/read/28060928/synanthropic-mammals-as-potential-hosts-of-tick-borne-pathogens-in-panama
#10
Sergio E Bermúdez, Nicole Gottdenker, Aparna Krishnvajhala, Amy Fox, Hannah K Wilder, Kadir González, Diorene Smith, Marielena López, Milixa Perea, Chystrie Rigg, Santiago Montilla, José E Calzada, Azael Saldaña, Carlos M Caballero, Job E Lopez
Synanthropic wild mammals can be important hosts for many vector-borne zoonotic pathogens. The aim of this study was determine the exposure of synanthropic mammals to two types of tick-borne pathogens in Panama, spotted fever group Rickettsia (SFGR) and Borrelia relapsing fever (RF) spirochetes. One hundred and thirty-one wild mammals were evaluated, including two gray foxes, two crab-eating foxes (from zoos), four coyotes, 62 opossum and 63 spiny rats captured close to rural towns. To evaluate exposure to SFGR, serum samples from the animals were tested by indirect immunofluorescence assay (IFA) using Rickettsia rickettsii and Candidatus Rickettsia amblyommii antigen...
2017: PloS One
https://www.readbyqxmd.com/read/28057539/effects-of-ibuprofen-on-cognition-and-nmda-receptor-subunit-expression-across-aging
#11
Alejandra Márquez Loza, Valerie Elias, Carmen P Wong, Emily Ho, Michelle Bermudez, Kathy R Magnusson
Age-related declines in long- and short-term memory show relationships to decreases in N-methyl-d-aspartate (NMDA) receptor expression, which may involve inflammation. This study was designed to determine effects of an anti-inflammatory drug, ibuprofen, on cognitive function and NMDA receptor expression across aging. Male C57BL/6 mice (ages 5, 14, 20, and 26months) were fed ibuprofen (375ppm) in NIH31 diet or diet alone for 6weeks prior to testing. Behavioral testing using the Morris water maze showed that older mice performed significantly worse than younger in spatial long-term memory, reversal, and short-term memory tasks...
January 3, 2017: Neuroscience
https://www.readbyqxmd.com/read/28045536/plasmonic-waveguide-integrated-nanowire-laser
#12
Esteban Bermúdez-Ureña, Gozde Tutuncuoglu, Javier Cuerda, Cameron L C Smith, Jorge Bravo-Abad, Sergey I Bozhevolnyi, Anna Fontcuberta I Morral, Francisco J García-Vidal, Romain Quidant
Next-generation optoelectronic devices and photonic circuitry will have to incorporate on-chip compatible nanolaser sources. Semiconductor nanowire lasers have emerged as strong candidates for integrated systems with applications ranging from ultrasensitive sensing to data communication technologies. Despite significant advances in their fundamental aspects, the integration within scalable photonic circuitry remains challenging. Here we report on the realization of hybrid photonic devices consisting of nanowire lasers integrated with wafer-scale lithographically designed V-groove plasmonic waveguides...
January 9, 2017: Nano Letters
https://www.readbyqxmd.com/read/28031459/%C3%AE-4%C3%AE-2-nicotinic-acetylcholine-receptors-relationships-between-subunit-stoichiometry-and-function-at-the-single-channel-level
#13
Simone Mazzaferro, Isabel Bermudez, Steven M Sine
Acetylcholine receptors (AChRs) comprised of α4 and β2 subunits are the most abundant class of nicotinic AChR in the brain. They contribute to cognition, reward, mood and nociception, and are implicated in a range of neurological disorders. Previous measurements of whole-cell macroscopic currents showed that α4 and β2 subunits assemble in two predominant pentameric stoichiometries, which differ in their sensitivity to agonists, antagonists and allosteric modulators. Here we compare agonist-elicited single channel currents from receptors assembled with an excess of either the α4 or β2 subunit, forming receptor populations biased toward one or the other stoichiometry, with currents from receptors composed of five concatemeric subunits in which the subunit stoichiometry is predetermined...
December 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28018010/uveal-melanoma-cell-lines-where-do-they-come-from-an-american-ophthalmological-society-thesis
#14
Martine J Jager, J Antonio Bermudez Magner, Bruce R Ksander, Sander R Dubovy
PURPOSE: To determine whether some of the most often used uveal melanoma cell lines resemble their original tumor. METHODS: Analysis of the literature, patient charts, histopathology, mutations, chromosome status, HLA type, and expression of melanocyte markers on cell lines and their primary tumors. We examined five cell lines and the primary tumors from which they were derived. RESULTS: Four of the five examined primary tumors were unusual: one occupied the orbit, two were recurrences after prior irradiation, and one developed in an eye with a nevus of Ota...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/28012727/diagnosis-of-gynecological-pseudoaneurysms-and-embolization-with-cyanoacrylate
#15
M J Fernández Bermúdez, A M Fernández Martínez, L A Domitrovic, Ó Balboa Arregui
Pseudoaneurysms of the uterine artery are an uncommon cause of severe gynecological bleeding secondary to surgical manipulation of the pelvis or to instrumental delivery. The different imaging techniques are of vital importance in the diagnosis. Angiography is the technique used for confirmation and also for treatment in many cases. Endovascular treatment by embolizing the pseudoaneurysm has become established as the treatment of choice, making it possible to avoid hysterectomy in women of childbearing age...
December 21, 2016: Radiología
https://www.readbyqxmd.com/read/28011191/determinants-to-trigger-memory-reconsolidation-the-role-of-retrieval-and-updating-information
#16
Carlos J Rodriguez-Ortiz, Federico Bermúdez-Rattoni
Long-term memories can undergo destabilization/restabilization processes, collectively called reconsolidation. However, the parameters that trigger memory reconsolidation are poorly understood and are a matter of intense investigation. Particularly, memory retrieval is widely held as requisite to initiate reconsolidation. This assumption makes sense since only relevant cues will induce reconsolidation of a specific memory. However, recent studies show that pharmacological inhibition of retrieval does not avoid memory from undergoing reconsolidation, indicating that memory reconsolidation occurs through a process that can be dissociated from retrieval...
December 21, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28005446/the-effect-of-agave-tequilana-weber-inulin-on-postprandial-ghrelin-concentration-in-obese-patients
#17
Betsabe Contreras-Haro, Jose A Robles-Cervantes, Manuel Gonzalez-Ortiz, Esperanza Martinez-Abundis, Claudia Espinel-Bermudez, Martha P Gallegos-Arreola, Karina C Morgado-Castillo
This study was performed to investigate the effect of Agave tequilana Weber inulin on postprandial ghrelin levels in obese patients. A randomized, double-blind, cross-over design was performed. A total of 14 patients were allocated into two groups: one group received a drink that contained 500 mL lemon water, 24 g of A. tequilana Weber inulin, and 75 g glucose and the other group received a placebo drink with 500 mL lemon drink and 75 g of glucose. After a 7-day washout period, the groups were crossed...
December 22, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28002359/safety-and-immunogenicity-of-the-quadrivalent-meningococcal-serogroups-a-c-w-and-y-tetanus-toxoid-conjugate-vaccine-co-administered-with-routine-childhood-vaccines-in-european-infants-an-open-randomized-trial
#18
Jose Manuel Merino Arribas, Alfonso Carmona Martínez, Michael Horn, Xavier Maria Perez Porcuna, Maria Del Carmen Otero Reigada, Josep Marès Bermúdez, Fernando Centeno Malfaz, Mariano Miranda, Maria Mendez, Miguel Angel Garcia Cabezas, Christoph Wittermann, Gerhard Bleckmann, Thomas Fischbach, Devayani Kolhe, Marie van der Wielen, Yaela Baine
BACKGROUND: This was the first study evaluating the immunogenicity and safety of the quadrivalent meningococcal tetanus toxoid conjugate vaccine (MenACWY-TT) co-administered with routine childhood vaccines in young infants. METHODS: In this open, randomized, controlled, phase III study (NCT01144663), 2095 infants (aged 6-12 weeks) were randomized (1:1:1:1) into 4 groups to receive MenACWY-TT at 2, 3, 4 and 12 months of age, or MenACWY-TT, MenC-CRM197 or MenC-TT at 2, 4 and 12 months of age...
December 19, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27994659/interferon-tau-has-antiproliferative-effects-represses-the-expression-of-e6-and-e7-oncogenes-induces-apoptosis-in-cell-lines-transformed-with-hpv16-and-inhibits-tumor-growth-in-vivo
#19
Herbey Oswaldo Padilla-Quirarte, Cesar Trejo-Moreno, Geny Fierros-Zarate, Jhoseline Carnalla Castañeda, Marie Palma-Irizarry, Eva Hernández-Márquez, Ana Isabel Burguete-Garcia, Oscar Peralta-Zaragoza, Vicente Madrid-Marina, Kirvis Torres-Poveda, Victor Hugo Bermúdez-Morales
Interferon tau (IFN-τ) is a promising alternative antiviral and immunotherapeutic agent in a wide variety of diseases including infectious, neurodegenerative, autoimmune and cancer due to its low toxicity in comparison with other type I interferon´s. The objective of our study was established the effect of the bovine IFN-τ on human (SiHa) and murine (BMK-16/myc) cells transformed with HPV 16 and evaluates the antitumor effect in a murine tumor model HPV 16 positive. We determine that bovine IFN-τ has antiproliferative effects, pro-apoptotic activity and induces repression of viral E6 and E7 oncogenes (time- and dose-dependent) on human and murine cells transformed with HPV 16 similar to the effects of IFN-β...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27994510/pathological-characterization-of-ifnar-mice-infected-with-bluetongue-virus-serotype-4
#20
Alejandro Marín-López, Roberto Bermúdez, Eva Calvo-Pinilla, Sandra Moreno, Alejandro Brun, Javier Ortego
Bluetongue virus (BTV) replicates in lymphoid tissues where infected mononuclear leukocytes secrete proinflammatory and vasoactive mediators that can contribute to bluetongue (BT) pathogenesis. Using the well-characterized IFNAR(-/-) mice animal model, we have now studied the histopathology and dynamics of leukocyte populations in different target tissues (spleen, thymus, and lung) during BTV-4 infection by histological and immunohistochemical techniques. The spleen and thymus of BTV-4 infected mice showed severe lymphoid depletion on H&E stained sections...
2016: International Journal of Biological Sciences
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