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https://www.readbyqxmd.com/read/27912148/anti-cancer-effect-of-lactic-acid-bacteria-expressing-antioxidant-enzymes-or-il-10-in-a-colorectal-cancer-mouse-model
#1
Silvina Del Carmen, Alejandra de Moreno de LeBlanc, Romina Levit, Vasco Azevedo, Philippe Langella, Luis G Bermúdez-Humarán, Jean Guy LeBlanc
The association between inflammatory bowel diseases and colorectal cancer is well documented. The genetic modification of lactic acid bacteria as a tool to increase the anti-inflammatory potential of these microorganisms has also been demonstrated. Thus the aim of the present work was to evaluate the anti-cancer potential of different genetically modified lactic acid bacteria (GM-LAB) producing antioxidant enzymes (catalase or superoxide dismutase) or the anti-inflammatory cytokine IL-10 (protein or DNA delivery) using a chemical induced colon cancer murine model...
November 29, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27912096/drugging-acat1-for-cancer-therapy
#2
Javier Garcia-Bermudez, Kivanç Birsoy
In this issue, Fan et al. (2016) show that oncogenic tyrosine kinases can promote glycolysis by phosphorylating and stabilizing the tetrameric form of mitochondrial acetyl-coA acetyltransferase 1 (ACAT1). The authors further identify a small molecule ACAT1 inhibitor that displays anti-cancer effects.
December 1, 2016: Molecular Cell
https://www.readbyqxmd.com/read/27903305/priorities-and-needs-for-research-on-urban-interventions-targeting-vector-borne-diseases-rapid-review-of-scoping-and-systematic-reviews
#3
EDITORIAL
Clara Bermudez-Tamayo, Olive Mukamana, Mabel Carabali, Lyda Osorio, Florence Fournet, Kounbobr Roch Dabiré, Celina Turchi Marteli, Adolfo Contreras, Valéry Ridde
This paper highlights the critical importance of evidence on vector-borne diseases (VBD) prevention and control interventions in urban settings when assessing current and future needs, with a view to setting policy priorities that promote inclusive and equitable urban health services. Research should produce knowledge about policies and interventions that are intended to control and prevent VBDs at the population level and to reduce inequities. Such interventions include policy, program, and resource distribution approaches that address the social determinants of health and exert influence at organizational and system levels...
December 1, 2016: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/27897435/-evaluation-of-an-immunochromatographic-test-for-the-detection-of-oxa-48-carbapenemase
#4
C Mediavilla-Gradolph, R Sáinz-Rodriguez, M Valverde-Troya, I de Toro-Peinado, M P Bermudez-Ruíz, B Palop-Borrás
OBJECTIVE: Detection and differentiation of various types of carbapenemases is crucial to their control and dissemination. OXA-48 is the most common carbapenemase in Spain and in our environment. The aim of this study is the evaluation of a new immunochromatographic test OXA-48 Card letitest (Coris, BioConcept Belgium) to detect this carbapenemase from solid media. METHODS: During the last year 151 strains of carbapenemase producing bacteria have been isolated, of which 136 were OXA-48 (126 Klebsiella pneumoniae, 1 Klebsiella oxytoca, 5 Escherichia coli, 4 Enterobacter cloacae), and 15 producing other carbapenemases ...
November 25, 2016: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/27896413/endovascular-revascularization-of-hemodialysis-thrombosed-grafts-with-the-hydrodynamic-thrombectomy-catheter-our-7-year-experience
#5
Patrícia Bermudez, Nestor Fontseré, Gaspar Mestres, Andres García-Gámez, Marta Barrufet, Marta Burrel, Rosa Gilabert, Fernando Gómez, Juan Macho
PURPOSE: To evaluate the efficacy and safety of the hydrodynamic thrombectomy catheter (AngioJet DVX) in the salvage of thrombosed hemodialysis vascular grafts. MATERIALS AND METHODS: A retrospective study was designed, including all patients with occluded arteriovenous grafts treated with the AngioJet system between 2007 and 2014 in our institution. Outcomes included technical success, clinical success, complications, and primary and secondary patencies. Procedural success was defined as angiographic confirmation of flow restoration, the presence of a pulsatile thrill along the graft, and successful resumption of at least one hemodialysis session...
November 28, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27892502/mitochondrial-fat-oxidation-is-essential-for-lipid-induced-inflammation-in-skeletal-muscle-in-mice
#6
Jaycob D Warfel, Estrellita M Bermudez, Tamra M Mendoza, Sujoy Ghosh, Jingying Zhang, Carrie M Elks, Randall Mynatt, Bolormaa Vandanmagsar
Inflammation, lipotoxicity and mitochondrial dysfunction have been implicated in the pathogenesis of obesity-induced insulin resistance and type 2 diabetes. However, how these factors are intertwined in the development of obesity/insulin resistance remains unclear. Here, we examine the role of mitochondrial fat oxidation on lipid-induced inflammation in skeletal muscle. We used skeletal muscle-specific Cpt1b knockout mouse model where the inhibition of mitochondrial fatty acid oxidation results in accumulation of lipid metabolites in muscle and elevated circulating free fatty acids...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27885367/olive-oil-and-postprandial-hyperlipidemia-implications-for-atherosclerosis-and-metabolic-syndrome
#7
REVIEW
Sergio Montserrat-de la Paz, Beatriz Bermudez, Magdalena P Cardelo, Sergio Lopez, Rocio Abia, Francisco J G Muriana
Olive oil is the primary source of fat in the Mediterranean diet, which is associated with a significant improvement in health status, as measured by reduced mortality from several chronic diseases. The current pandemic of obesity, metabolic syndrome, and type 2 diabetes is intimately associated with an atherogenic dyslipidemic phenotype. The core components of the dyslipidemia of the metabolic syndrome, which most likely initiate atherosclerosis, are the "lipid triad" consisting of high plasma triglycerides, low levels of high-density lipoproteins, and a preponderance of small, dense low-density lipoproteins at fasting...
November 25, 2016: Food & Function
https://www.readbyqxmd.com/read/27877210/in-vivo-antitumor-effect-of-an-hpv-specific-promoter-driving-il-12-expression-in-an-hpv-16-positive-murine-model-of-cervical-cancer
#8
Victor Hugo Bermúdez-Morales, Geny Fierros-Zarate, Celina García-Meléndrez, Juan Manuel Alcocer-Gonzalez, Ausencio Morales-Ortega, Oscar Peralta-Zaragoza, Kirvis Torres-Poveda, Ana Isabel Burguete-García, Eva Hernández-Márquez, Vicente Madrid-Marina
Human papillomavirus (HPV) is a DNA virus that infects epithelial cells and has been implicated in the development of cervical cancer. Few therapeutic strategies have been designed for the treatment of cervical intraepithelial neoplasia, a precursor of cervical cancer. In these early stages, the HPV E2 protein is the most important viral factor involved in viral gene expression and plays crucial roles during the vegetative viral cycle in epithelial cells. Papillomavirus E2 binds specifically to palindromic ACCN6GGT sequences, referred to as the E2 binding sites (E2BS), which are concentrated within the viral long control region, and which are responsible for regulation of the HPV protein's expression...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27876851/the-genome-transcriptome-and-proteome-of-the-nematode-steinernema-carpocapsae-evolutionary-signatures-of-a-pathogenic-lifestyle
#9
Alejandra Rougon-Cardoso, Mitzi Flores-Ponce, Hilda Eréndira Ramos-Aboites, Christian Eduardo Martínez-Guerrero, You-Jin Hao, Luis Cunha, Jonathan Alejandro Rodríguez-Martínez, Cesaré Ovando-Vázquez, José Roberto Bermúdez-Barrientos, Cei Abreu-Goodger, Norberto Chavarría-Hernández, Nelson Simões, Rafael Montiel
The entomopathogenic nematode Steinernema carpocapsae has been widely used for the biological control of insect pests. It shares a symbiotic relationship with the bacterium Xenorhabdus nematophila, and is emerging as a genetic model to study symbiosis and pathogenesis. We obtained a high-quality draft of the nematode's genome comprising 84,613,633 bp in 347 scaffolds, with an N50 of 1.24 Mb. To improve annotation, we sequenced both short and long RNA and conducted shotgun proteomic analyses. S. carpocapsae shares orthologous genes with other parasitic nematodes that are absent in the free-living nematode C...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27869385/-phenotypic-and-molecular-characterization-of-a-colombian-family-with-phenylketonuria
#10
Nancy Gélvez, Johana Acosta, Greizy López, Derly Castro, Juan Carlos Prieto, Martha Bermúdez, Marta L Tamayo
Phenylketonuria is a metabolic disorder characterized by severe neurological involvement and behavioral disorder, whose early diagnosis enables an effective treatment to avoid disease sequelae, thus changing the prognosis. Objective: To characterize a family with phenylketonuria in Colombia at clinical, biochemical and molecular levels. Materials and methods: The population consisted of seven individuals of a consanguineous family with four children with suggestive symptoms of phenylketonuria. After signing an informed consent, blood and urine samples were taken for colorimetric tests and high performance liquid and thin layer chromatographies...
September 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27864368/role-of-the-cys-loop-and-transmembrane-domain-in-the-allosteric-modulation-of-%C3%AE-4%C3%AE-2-nicotinic-acetylcholine-receptors
#11
Constanza Alcaino, Maria Musgaard, Teresa Minguez, Simone Mazzaferro, Manuel Faundez, Patricio Iturriaga-Vasquez, Philip C Biggin, Isabel Bermudez
Allosteric modulators of pentameric ligand gated ion channels (pLGICs) are thought to act on elements of the pathways that couple agonist binding to channel gating. Using α4β2 nicotinic acetylcholine receptors (nAChRs) and the α4β2-selective positive modulators 17β-estradiol (βEST) and desformylflustrabromine (dFBr), we have identified pathways that link the binding sites for these modulators to the Cys loop, a region that is critical for channel gating in all pLGICs. Previous studies have shown that the binding site for potentiating βEST is in the C-terminal (post-M4 region) of the α4 subunit...
November 18, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27864089/anaphylaxis-induced-by-ingested-molds
#12
Ricardo Moreno-Borque, Teresa Collazo-Lorduy, Mariangélica Bermúdez-Martínez, Pilar Gajate-Fernández, Paula Sánchez-López, María Moreno-Geada, Nuria Plaza-Sánchez
No abstract text is available yet for this article.
November 15, 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27859114/on-the-dual-nature-of-lichen-induced-rock-surface-weathering-in-contrasting-micro-environments
#13
Joana Marques, João Gonçalves, Cláudia Oliveira, Sergio E Favero-Longo, Graciela Paz-Bermúdez, Rubim Almeida, Beatriz Prieto
Contradictory evidence from biogeomorphological studies has increased the debate on the extent of lichen contribution to differential rock surface weathering in both natural and cultural settings. This study, undertaken in Côa Valley Archaeological Park, aimed at evaluating the effect of rock surface orientation on the weathering ability of dominant lichens. Hyphal penetration and oxalate formation at the lichen-rock interface were evaluated as proxies of physical and chemical weathering, respectively. A new protocol of pixel-based supervised image classification for the analysis of periodic acid-Schiff stained cross-sections of colonized schist revealed that hyphal spread of individual species was not influenced by surface orientation...
October 2016: Ecology
https://www.readbyqxmd.com/read/27856021/interdisciplinary-development-of-an-improved-emergency-department-procedural-work-surface-through-iterative-design-and-use-testing-in-simulated-and-clinical-environments
#14
Xiao C Zhang, Ana M Bermudez, Pranav M Reddy, Ravi R Sarpatwari, Darin B Chheng, Taylor J Mezoian, Victoria R Schwartz, Quinneil J Simmons, Gregory D Jay, Leo Kobayashi
STUDY OBJECTIVE: A stable and readily accessible work surface for bedside medical procedures represents a valuable tool for acute care providers. In emergency department (ED) settings, the design and implementation of traditional Mayo stands and related surface devices often limit their availability, portability, and usability, which can lead to suboptimal clinical practice conditions that may affect the safe and effective performance of medical procedures and delivery of patient care...
November 14, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27847083/incomplete-double-aortic-arch-in-an-adult-presenting-with-bilateral-pneumonia
#15
Luis Gorospe, Sandra Bermúdez-Nieto, Ernesto García-Santana, Paola Arrieta, Javier Gaudó-Navarro, Ana Paz Valdebenito-Montecino, Javier Miguelena-Hycka
No abstract text is available yet for this article.
December 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27845018/is-lack-of-antibiotic-usage-affecting-udder-health-status-of-organic-dairy-cattle
#16
Inmaculada Orjales, Marta López-Alonso, Ruth Rodríguez-Bermúdez, Francisco Rey-Crespo, Ana Villar, Marta Miranda
This research communication aimed to compare somatic cell count (SCC), the main marker of udder health status, in organic farms not using antibiotics (O, n = 6), organic farms using antibiotics (OA, n = 7) and conventional farms (CA, n = 5) using antibiotic treatments, all of them at pasture. SCC was statistically significantly higher in O (173780) compared to CA (93325) and OA (107152). Milk yield had a significant diluting effect on SCC and differences between groups increased with parities. Stratified analysis of SCC depending on lactation number and % of monthly SCC test with different linear scores (LS) indicated that there is no difference in udder health in the primiparous heifers from the three groups of farms, but it deteriorates in older cows because of chronic infections in O (possibly due to lack of antibiotic use)...
November 2016: Journal of Dairy Research
https://www.readbyqxmd.com/read/27842947/extracorporeal-support-during-bilateral-sequential-lung-transplantation-in-patients-with-pulmonary-hypertension-risk-factors-and-outcomes
#17
Pranav R Shah, Michael L Boisen, Daniel G Winger, Jose Marquez, Christian A Bermudez, Jay K Bhama, Norihisa Shigemura, Jonathan D'Cuhna, Kathirvel Subramaniam
OBJECTIVE: To identify preoperative predictors of extracorporeal support in patients with pulmonary hypertension (PH) undergoing bilateral sequential lung transplantation (LTx), and to examine outcomes associated with the use of extracorporeal support. DESIGN: Retrospective, observational study. SETTING: Single organ transplantation and tertiary care university medical center. PARTICIPANTS: Adults with PH (preoperative mean pulmonary artery pressure (mPAP)≥25 mmHg) who underwent primary bilateral sequential LTx during 2007 to 2013...
August 18, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27835835/effect-of-natural-antioxidants-in-spanish-salchich%C3%A3-n-elaborated-with-encapsulated-n-3-long-chain-fatty-acids-in-konjac-glucomannan-matrix
#18
P E S Munekata, R Domínguez, D Franco, R Bermúdez, M A Trindade, Jose M Lorenzo
The effect of natural antioxidants on physicochemical properties, lipid and protein oxidation, volatile compounds and free fatty acids (FFA) were determined in Spanish salchichón enriched with n-3 fatty acids encapsulated and stabilized in konjac matrix. Phenolic compounds of beer residue extract (BRE), chestnut leaves extract (CLE) and peanut skin extract (PSE) were also identified and quantified. Five batches of salchichón were prepared: control (CON, without antioxidants), butylated hydroxytoluene (BHT), BRE, CLE and PSE...
November 5, 2016: Meat Science
https://www.readbyqxmd.com/read/27832790/erratum-to-protective-effect-of-tslp-delivered-at-the-gut-mucosa-level-by-recombinant-lactic-acid-bacteria-in-dss-induced-colitis-mouse-model
#19
Camille Aubry, Christophe Michon, Florian Chain, Yolande Chvatchko, Laurence Goffin, Simone C Zimmerli, Sylvia Leguin, Philippe Langella, Luis Bermudez-Humaran, Jean-Marc Chatel
No abstract text is available yet for this article.
November 10, 2016: Microbial Cell Factories
https://www.readbyqxmd.com/read/27829372/identification-of-mycobacterium-avium-subsp-hominissuis-secreted-proteins-using-an-in-vitro-system-mimicking-the-phagosomal-environment
#20
Jessica J Chinison, Lia Danelishvili, Rashmi Gupta, Sasha J Rose, Lmar M Babrak, Luiz E Bermudez
BACKGROUND: Mycobacterium avium subsp. hominissuis is a common intracellular pathogen that infects patients with HIV/AIDS and cause lung infection in patients with underlying lung pathology. M.avium preferably infects macrophages and uses diverse mechanisms to alter phagosome maturation. Once in the macrophage, the pathogen can alter the host cellular defenses by secreting proteins into the cytosol of host cells, but despite considerable research, only a few secreted effector proteins have been identified...
November 9, 2016: BMC Microbiology
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