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JOURNAL ARTICLE
John C Greenwood, Fatima M Talebi, David H Jang, Audrey E Spelde, Emily K Gordon, Jiri Horak, Michael A Acker, Todd J Kilbaugh, Frances S Shofer, John G T Augoustides, Jacob S Brenner, Vladimir R Muzykantov, Jan Bakker, Benjamin S Abella
OBJECTIVES: Quantify the relationship between perioperative anaerobic lactate production, microcirculatory blood flow, and mitochondrial respiration in patients after cardiovascular surgery with cardiopulmonary bypass. DESIGN: Serial measurements of lactate-pyruvate ratio (LPR), microcirculatory blood flow, plasma tricarboxylic acid cycle cycle intermediates, and mitochondrial respiration were compared between patients with a normal peak lactate (≤ 2 mmol/L) and a high peak lactate (≥ 4 mmol/L) in the first 6 hours after surgery...
April 5, 2024: Critical Care Medicine
#2
JOURNAL ARTICLE
Ashley E Kim, Julia C Bennett, Kyle Luiten, Jessica A O'Hanlon, Caitlin R Wolf, Ariana Magedson, Peter D Han, Zack Acker, Lani Regelbrugge, Kathryn M McCaffrey, Jeremey Stone, David Reinhart, Benjamin J Capodanno, Stephen S Morse, Trevor Bedford, Janet A Englund, Michael Boeckh, Lea M Starita, Timothy M Uyeki, Marco Carone, Ana Weil, Helen Y Chu
BACKGROUND: SARS-CoV-2 antigen-detection rapid diagnostic tests (Ag-RDTs) have become widely utilized but longitudinal characterization of their community-based performance remains incompletely understood. METHODS: This prospective longitudinal study at a large public university in Seattle, WA utilized remote enrollment, online surveys, and self-collected nasal swab specimens to evaluate Ag-RDT performance against real-time reverse transcription polymerase chain reaction (rRT-PCR) in the context of SARS-CoV-2 Omicron...
March 26, 2024: Journal of Infectious Diseases
#3
JOURNAL ARTICLE
Caroline Melhado, Rachelle Durand, Katie W Russell, Natalya E Polukoff, John Rampton, Rajiv R Iyer, Shannon N Acker, Richele Koehler, Connor Prendergast, Nicholas Stence, Brent O'Neill, Benjamin E Padilla, Ramin Jamshidi, Jennifer A Vaughn, Jennifer S Ronecker, Leigh Selesner, Katrine Lofberg, Michael Regner, Jaclyn Thiessen, Christine Sayama, Ryan G Spurrier, Erin E Ross, Chia-Shang Jason Liu, Jason Chu, Kathryn McNevin, Catherine Beni, Bryce R H Robinson, Ken Linnau, Robert T Buckley, Stephanie D Chao, Akanksha Sabapaty, Elizabeth Tong, Laura M Prolo, Romeo Ignacio, Gretchen Floan Sachs, Peter Kruk, David Gonda, Mark Ryan, Samir Pandya, Korgun Koral, Bruno P Braga, Kurtis Auguste, Aaron R Jensen
INTRODUCTION: Clinical clearance of a child's cervical spine after trauma is often challenging due to impaired mental status or an unreliable neurologic examination. Magnetic resonance imaging (MRI) is the gold standard for excluding ligamentous injury in children but is constrained by long image acquisition times and frequent need for anesthesia. Limited-sequence MRI (LSMRI) is used in evaluating the evolution of traumatic brain injury and may also be useful for cervical spine clearance while potentially avoiding the need for anesthesia...
March 25, 2024: Journal of Trauma and Acute Care Surgery
#4
JOURNAL ARTICLE
Ziya Isiksacan, Angelo D'Alessandro, David H McKenna, Shannon N Tessier, Erdem Kucukal, A Aslihan Gokaltun, Nishaka William, Rebecca D Sandlin, John Bischof, Narla Mohandas, Michael P Busch, Caglar Elbuken, Umut A Gurkan, Mehmet Toner, Jason P Acker, Martin L Yarmush, O Berk Usta
No abstract text is available yet for this article.
March 12, 2024: Proceedings of the National Academy of Sciences of the United States of America
#5
JOURNAL ARTICLE
Lili Liu, Wanqing Wen, Martha J Shrubsole, Loren E Lipworth, Michael T Mumma, Brooke A Ackerly, Xiao-Ou Shu, William J Blot, Wei Zheng
INTRODUCTION: Low socioeconomic status has been linked to increased mortality. However, the impacts of poverty, alone or combined with health behaviors, on mortality and life expectancy have not been adequately investigated. METHODS: Data from the Southern Community Cohort Study was used, including nearly 86,000 participants recruited during 2002-2009 across 12 US southeastern states. Analysis was conducted from February 2022 to January 2023. RESULTS: During a median follow-up of 12...
February 26, 2024: American Journal of Preventive Medicine
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REVIEW
Nicole P Juffermans, Tarik Gözden, Karim Brohi, Ross Davenport, Jason P Acker, Michael C Reade, Marc Maegele, Matthew D Neal, Philip C Spinella
Improvements have been made in optimizing initial care of trauma patients, both in prehospital systems as well as in the emergency department, and these have also favorably affected longer term outcomes. However, as specific treatments for bleeding are largely lacking, many patients continue to die from hemorrhage. Also, major knowledge gaps remain on the impact of tissue injury on the host immune and coagulation response, which hampers the development of interventions to treat or prevent organ failure, thrombosis, infections or other complications of trauma...
February 13, 2024: Critical Care: the Official Journal of the Critical Care Forum
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JOURNAL ARTICLE
Laxminarayana Korutla, Jessica R Hoffman, Susan Rostami, Robert Hu, Varun Korutla, Caroline Markmann, Clancy Mullan, Alex Sotolongo, Andreas Habertheuer, Connie Romano, Michael Acker, Sounok Sen, Divyansh Agarwal, Arun Jayaraman, Bo Li, Michael E Davis, Ali Naji, Prashanth Vallabhajosyula
There is a critical need for biomarkers of acute cellular rejection (ACR) in organ transplantation. We hypothesized that ACR leads to changes in donor-reactive T cell small extracellular vesicle (sEV) profiles in transplant recipient circulation that match the kinetics of alloreactive T cell activation. In rodent heart transplantation, circulating T cell sEV quantities (P < .0001) and their protein and mRNA cargoes showed time-specific expression of alloreactive and regulatory markers heralding early ACR in allogeneic transplant recipients but not in syngeneic transplant recipients...
October 30, 2023: American Journal of Transplantation
#8
Fotios Pitoulis, Blanca Pamias-Lopez, Charlie Fraser, Akhil Rao, Lisa Mangino-Blanchard, William Vernick, Ronak Shah, Jeremy Kukafka, Audrey Spelde, Michael Acker, Wilson Szeto, Michael Ibrahim
Vascular and valvular calcifications, commonly seen in renal patients, increase operative mortality and can preclude conventional valvular management. We show a novel approach to treat aortic stenosis and degenerative mitral regurgitation under hypothermic circulatory arrest in a hemodialysis patient with aortic, mitral disease and porcelain aorta with surgical and transcatheter contraindications.
January 3, 2024: JACC. Case reports
#9
RANDOMIZED CONTROLLED TRIAL
Infarct-related structural disconnection and delirium in surgical aortic valve replacement patients.
Jeffrey N Browndyke, Lewis E Tomalin, Guray Erus, Jessica R Overbey, Amy Kuceyeski, Alan J Moskowitz, Emilia Bagiella, Alexander Iribarne, Michael Acker, Michael Mack, Joseph Mathew, Patrick O'Gara, Annetine C Gelijns, Mayte Suarez-Farinas, Steven R Messé
OBJECTIVE: Although acute brain infarcts are common after surgical aortic valve replacement (SAVR), they are often unassociated with clinical stroke symptoms. The relationship between clinically "silent" infarcts and in-hospital delirium remains uncertain; obscured, in part, by how infarcts have been traditionally summarized as global metrics, independent of location or structural consequence. We sought to determine if infarct location and related structural connectivity changes were associated with postoperative delirium after SAVR...
February 2024: Annals of Clinical and Translational Neurology
#10
JOURNAL ARTICLE
Leah Acker, Megan K Wong, Mary C Wright, Melody Reese, Charles M Giattino, Kenneth C Roberts, Sandra Au, Cathleen Colon-Emeric, Lewis A Lipsitz, Michael J Devinney, Jeffrey Browndyke, Sarada Eleswarpu, Eugene Moretti, Heather E Whitson, Miles Berger, Marty G Woldorff
BACKGROUND: In the eyes-closed, awake condition, EEG oscillatory power in the alpha band (7-13 Hz) dominates human spectral activity. With eyes open, however, EEG alpha power substantially decreases. Less alpha attenuation with eyes opening has been associated with inattention; thus, we analysed whether reduced preoperative alpha attenuation with eyes opening is associated with postoperative inattention, a delirium-defining feature. METHODS: Preoperative awake 32-channel EEG was recorded with eyes open and eyes closed in 71 non-neurological, noncardiac surgery patients aged ≥ 60 years...
January 2024: British Journal of Anaesthesia
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JOURNAL ARTICLE
Utsav M Patwardhan, Gretchen M Floan, Richard Y Calvo, Shannon N Acker, Pamela M Choi, James M Prieto, Vishal Bansal, Michael J Sise, Hari Thangarajah, Timothy J Fairbanks, David A Lazar, Romeo C Ignacio
INTRODUCTION: There is limited literature on the optimal approach to treat adhesive small bowel obstruction (ASBO) in children. We sought to compare rates and outcomes of laparoscopic (LAP) and open (OPEN) surgery for pediatric ASBO. METHODS: A California statewide database was used to identify children (<18 years old) with an index ASBO from 2007 to 2020. The primary outcome was the type of operative management: LAP or OPEN. Secondary outcomes were hospital characteristics, patient demographics, and postoperative complications...
October 21, 2023: Journal of Pediatric Surgery
#12
Mariko Takahashi, Harrison B Chong, Siwen Zhang, Matthew J Lazarov, Stefan Harry, Michelle Maynard, Ryan White, Heather E Murrey, Brendan Hilbert, Jason R Neil, Magdy Gohar, Maolin Ge, Junbing Zhang, Benedikt R Durr, Gregory Kryukov, Chih-Chiang Tsou, Natasja Brooijmans, Aliyu Sidi Omar Alghali, Karla Rubio, Antonio Vilanueva, Drew Harrison, Ann-Sophie Koglin, Samuel Ojeda, Barbara Karakyriakou, Alexander Healy, Jonathan Assaad, Farah Makram, Inbal Rachman, Neha Khandelwal, Pei-Chieh Tien, George Popoola, Nicholas Chen, Kira Vordermark, Marianne Richter, Himani Patel, Tzu-Yi Yang, Hanna Griesshaber, Tobias Hosp, Sanne van den Ouweland, Toshiro Hara, Lily Bussema, Rui Dong, Lei Shi, Martin Q Rasmussen, Ana Carolina Domingues, Aleigha Lawless, Jacy Fang, Satoshi Yoda, Linh Phuong Nguyen, Sarah Marie Reeves, Farrah Nicole Wakefield, Adam Acker, Sarah Elizabeth Clark, Taronish Dubash, David E Fisher, Shyamala Maheswaran, Daniel A Haber, Genevieve Boland, Moshe Sade-Feldman, Russel Jenkins, Aaron Hata, Nabeel Bardeesy, Mario L Suva, Brent Martin, Brian Liau, Christopher Ott, Miguel N Rivera, Michael S Lawrence, Liron Bar-Peled
Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors of a wide-range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To address this question, we have developed DrugMap , an atlas of cysteine ligandability compiled across 416 cancer cell lines. We unexpectedly find that cysteine ligandability varies across cancer cell lines, and we attribute this to differences in cellular redox states, protein conformational changes, and genetic mutations...
October 23, 2023: bioRxiv
#13
JOURNAL ARTICLE
Kévin Cortacero, Brienne McKenzie, Sabina Müller, Roxana Khazen, Fanny Lafouresse, Gaëlle Corsaut, Nathalie Van Acker, François-Xavier Frenois, Laurence Lamant, Nicolas Meyer, Béatrice Vergier, Dennis G Wilson, Hervé Luga, Oskar Staufer, Michael L Dustin, Salvatore Valitutti, Sylvain Cussat-Blanc
An unresolved issue in contemporary biomedicine is the overwhelming number and diversity of complex images that require annotation, analysis and interpretation. Recent advances in Deep Learning have revolutionized the field of computer vision, creating algorithms that compete with human experts in image segmentation tasks. However, these frameworks require large human-annotated datasets for training and the resulting "black box" models are difficult to interpret. In this study, we introduce Kartezio, a modular Cartesian Genetic Programming-based computational strategy that generates fully transparent and easily interpretable image processing pipelines by iteratively assembling and parameterizing computer vision functions...
November 6, 2023: Nature Communications
#14
JOURNAL ARTICLE
Utsav M Patwardhan, Gretchen M Floan, Richard Y Calvo, Shannon N Acker, James M Prieto, Hari Thangarajah, Vishal Bansal, Michael J Sise, Timothy J Fairbanks, David A Lazar, Romeo C Ignacio
INTRODUCTION: To examine practice patterns and surgical outcomes of nonoperative versus operative management (OPM) of children presenting with an index adhesive small bowel obstruction (ASBO). METHODS: A California statewide health discharge database was used to identify children (<18 y old) with an index ASBO from 2007 to 2020. The primary study outcome was evaluating initial management patterns (nonoperative versus OPM and early [≤3 d] versus late surgery [>3 d]) of ASBO...
September 1, 2023: Journal of Surgical Research
#15
JOURNAL ARTICLE
John C Greenwood, Fatima M Talebi, David H Jang, Audrey E Spelde, Emily K Gordon, Jiri Horak, Michael A Acker, Todd J Kilbaugh, Frances S Shofer, John G T Augoustides, Jan Bakker, Jacob S Brenner, Vladimir R Muzykantov, Benjamin S Abella
INTRODUCTION: Microcirculatory dysfunction after cardiovascular surgery is associated with significant morbidity and worse clinical outcomes. Abnormal capillary blood flow can occur from multiple causes, including cytokine-mediated vascular endothelial injury, microthrombosis, and an inadequate balance between vasoconstriction and vasodilation. In response to proinflammatory cytokines, endothelial cells produce cellular adhesion molecules (CAMs) which regulate leukocyte adhesion, vascular permeability, and thus can mediate tissue injury...
August 22, 2023: Microvascular Research
#16
JOURNAL ARTICLE
James W Schurr, Ian Sigal, Asad Usman, Prakash Patel, Benedicte Lefebvre, Kristy Kurcik, Pavan Atluri, Michael Acker, Christian Bermudez, J Eduardo Rame, Thomas Hanff, Marisa Cevasco, Joyce Wald
Right ventricular (RV) dysfunction is common after left ventricular assist device (LVAD) implantation leading to clinical right heart failure (RHF) associated with worsened survival and quality of life. It is likely that intraoperative events such as anesthesia induction play a role in the development or unmasking of RV dysfunction in addition to known effects from hemodynamic changes that occur after LVAD implantation. The EACH-LVAD Study is a prospective, single-center, single-arm, observational cohort study of adult patients with advanced heart failure undergoing durable LVAD implantation with standard anesthesia induction...
October 1, 2023: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
#17
JOURNAL ARTICLE
Michael P D'Erasmo, Nicholas S Akins, Peipei Ma, Yao Jing, Sharon A Swanger, Savita K Sharma, Perry W Bartsch, David S Menaldino, Paul J Arcoria, Thi-Thien Bui, Alexandre Pons-Bennaceur, Phuong Le, James P Allen, Elijah Z Ullman, Kelsey A Nocilla, Jing Zhang, Riley E Perszyk, Sukhan Kim, Timothy M Acker, Azmain Taz, Samantha L Burton, Kevin Coe, Russell G Fritzemeier, Nail Burnashev, Hongjie Yuan, Dennis C Liotta, Stephen F Traynelis
Subunit-selective inhibition of N -methyl-d-aspartate receptors (NMDARs) is a promising therapeutic strategy for several neurological disorders, including epilepsy, Alzheimer's and Parkinson's disease, depression, and acute brain injury. We previously described the dihydroquinoline-pyrazoline (DQP) analogue 2a ( DQP-26 ) as a potent NMDAR negative allosteric modulator with selectivity for GluN2C/D over GluN2A/B. However, moderate (<100-fold) subunit selectivity, inadequate cell-membrane permeability, and poor brain penetration complicated the use of 2a as an in vivo probe...
August 11, 2023: ACS Chemical Neuroscience
#18
JOURNAL ARTICLE
Ziya Isiksacan, Angelo D'Alessandro, Susan M Wolf, David H McKenna, Shannon N Tessier, Erdem Kucukal, A Aslihan Gokaltun, Nishaka William, Rebecca D Sandlin, John Bischof, Narla Mohandas, Michael P Busch, Caglar Elbuken, Umut A Gurkan, Mehmet Toner, Jason P Acker, Martin L Yarmush, O Berk Usta
Transfusion of red blood cells (RBCs) is one of the most valuable and widespread treatments in modern medicine. Lifesaving RBC transfusions are facilitated by the cold storage of RBC units in blood banks worldwide. Currently, RBC storage and subsequent transfusion practices are performed using simplistic workflows. More specifically, most blood banks follow the "first-in-first-out" principle to avoid wastage, whereas most healthcare providers prefer the "last-in-first-out" approach simply favoring chronologically younger RBCs...
August 8, 2023: Proceedings of the National Academy of Sciences of the United States of America
#19
JOURNAL ARTICLE
Paul Acker, Francis Daunt, Sarah Wanless, Sarah J Burthe, Mark A Newell, Michael P Harris, Robert L Swann, Carrie Gunn, Tim I Morley, Jane M Reid
Dissecting joint micro-evolutionary and plastic responses to environmental perturbations requires quantifying interacting components of genetic and environmental variation underlying expression of key traits. This ambition is particularly challenging for phenotypically discrete traits where multiscale decompositions are required to reveal non-linear transformations of underlying genetic and environmental variation into phenotypic variation, and when effects must be estimated from incomplete field observations...
June 21, 2023: Evolution; International Journal of Organic Evolution
#20
JOURNAL ARTICLE
Maria Waltenberger, Marco M E Vogel, Denise Bernhardt, Stefan Münch, Sophie Dobiasch, Kristin J Redmond, Simon S Lo, Güliz Acker, Michael G Fehlings, Florian Ringel, Peter Vajkoczy, Bernhard Meyer, Stephanie E Combs
PURPOSE: Spinal metastases (SM) are a common radiotherapy (RT) indication. There is limited level I data to drive decision making regarding dose regimen (DR) and target volume definition (TVD). We aim to depict the patterns of care for RT of SM among German Society for Radiation Oncology (DEGRO) members. METHODS: An online survey on conventional RT and Stereotactic Body Radiation Therapy (SBRT) for SM, distributed via e‑mail to all DEGRO members, was completed by 80 radiation oncologists between February 24 and April 29, 2022...
June 5, 2023: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
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