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https://www.readbyqxmd.com/read/29349446/ameliorative-role-of-camel-whey-protein-and-rosuvastatin-on-induced-dyslipidemia-in-mice
#1
Nashwa Ahmed El-Shinnawy, Sahar Sobhy Abd Elhalem, Nawal Zakaria Haggag, Gamal Badr
The incidence of obesity is rapidly increasing throughout the world. Dyslipidemia is a major risk factor for a number of chronic diseases, including diabetes and cardiovascular diseases. This work presents a novel approach to study the activity of camel whey protein (WP) with antioxidant and anti-inflammatory properties as a cheap dietary protein substance extracted from camel milk to produce satiety and help in building muscles. Mice model suffering from dyslipidemia as a result of feeding on high fat-cholesterol diet for 8 weeks were administrated with either camel WP and/or rosuvastatin for 4 weeks...
January 19, 2018: Food & Function
https://www.readbyqxmd.com/read/29290819/identification-of-type-iv-collagen-exposure-as-a-molecular-imaging-target-for-early-detection-of-thoracic-aortic-dissection
#2
Ke Xu, Chen Xu, Yanzhenzi Zhang, Feiran Qi, Bingran Yu, Ping Li, Lixin Jia, Yulin Li, Fu-Jian Xu, Jie Du
Thoracic aortic dissection (TAD) is an aggressive and life-threatening vascular disease and there is no effective means of early diagnosis of dissection. Type IV collagen (Col-IV) is a major component of the sub-endothelial basement membrane, which is initially exposed followed by endothelial injury as early-stage event of TAD. So, we want to build a noninvasive diagnostic method to detect early dissection by identifying the exposed Col-IV via MRI. METHODS: Col-IV-targeted magnetic resonance/ fluorescence dual probe (Col-IV-DOTA-Gd-rhodamine B; CDR) was synthesized by amide reaction and coordination reaction...
2018: Theranostics
https://www.readbyqxmd.com/read/29283933/a-preventive-model-for-muscle-injuries-a-novel-approach-based-on-learning-algorithms
#3
Alejandro López-Valenciano, Francisco Ayala, José Miguel Puerta, Mark De Ste Croix, Francisco Vera-García, Sergio Hernández-Sánchez, Iñaki Ruiz-Pérez, Gregory Myer
INTRODUCTION: The application of contemporary statistical approaches coming from Machine Learning and Data Mining environments to build more robust predictive models to identify athletes at high risk of injury might support injury prevention strategies of the future. PURPOSE: The purpose was to analyse and compare the behaviour of numerous machine learning methods in order to select the best performing injury risk factor model to identify athlete at risk of lower extremity muscle injuries (MUSINJ)...
December 28, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29242821/regulation-of-regeneration-by-heparan-sulfate-proteoglycans-in-the-extracellular-matrix
#4
David M Gardiner
Just as the building of a house requires a blueprint, the rebuilding of lost or damaged body parts through regeneration requires a set of instructions for the assembly of the various tissues into the right places. Much progress has been made in understanding how to control the differentiation of different cell types to provide the building blocks for regeneration, such as bone, muscle, blood vessels and nerves/Schwann cells. These are the cells that follow the blueprint (the pattern-following cells) and end up in the right places relative to each other in order to restore the lost function...
September 2017: Regenerative Engineering and Translational Medicine
https://www.readbyqxmd.com/read/29240529/cross-sectional-associations-between-gender-linked-personality-traits-and-use-of-weight-loss-and-muscle-building-products-among-u-s-young-adults
#5
Vivienne M Hazzard, Kelley A Borton, Katherine W Bauer, Kendrin R Sonneville
This study examined the cross-sectional associations between gender-linked personality traits and use of products for weight loss and muscle building using data from young adults participating in Wave III of the National Longitudinal Study of Adolescent to Adult Health who completed the short-form Bem Sex-Role Inventory (n = 3,343). Among men, a higher score on the masculinity scale was associated with greater odds of diet pill use, legal performance-enhancing substance (PES) use, and illicit PES use, while a higher score on the femininity scale was associated with lower odds of illicit PES use...
December 14, 2017: Eating Disorders
https://www.readbyqxmd.com/read/29227919/a-subject-specific-biomechanical-control-model-for-the-prediction-of-cervical-spine-muscle-forces
#6
Maxim Van den Abbeele, Fan Li, Vincent Pomero, Dominique Bonneau, Baptiste Sandoz, Sébastien Laporte, Wafa Skalli
BACKGROUND: The aim of the present study is to propose a subject-specific biomechanical control model for the estimation of active cervical spine muscle forces. METHODS: The proprioception-based regulation model developed by Pomero et al. (2004) for the lumbar spine was adapted to the cervical spine. The model assumption is that the control strategy drives muscular activation to maintain the spinal joint load below the physiological threshold, thus avoiding excessive intervertebral displacements...
December 6, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29227103/a-robust-molecular-network-motif-for-period-doubling-devices
#7
Christian Cuba Samaniego, Elisa Franco
Life is sustained by a variety of cyclic processes such as cell division, muscle contraction, and neuron firing. The periodic signals powering these processes often direct a variety of other downstream systems, which operate at different time scales and must have the capacity to divide or multiply the period of the master clock. Period modulation is also an important challenge in synthetic molecular systems, where slow and fast components may have to be coordinated simultaneously by a single oscillator whose frequency is often difficult to tune...
December 11, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29197960/sarcopenia-during-neoadjuvant-therapy-for-oesophageal-cancer-characterising-the-impact-on-muscle-strength-and-physical-performance
#8
Emer M Guinan, S L Doyle, A E Bennett, L O'Neill, J Gannon, J A Elliott, J O'Sullivan, J V Reynolds, J Hussey
PURPOSE: Preoperative chemo(radio)therapy for oesophageal cancer (OC) may have an attritional impact on body composition and functional status, impacting postoperative outcome. Physical decline with skeletal muscle loss has not been previously characterised in OC and may be amenable to physical rehabilitation. This study characterises skeletal muscle mass and physical performance from diagnosis to post-neoadjuvant therapy in patients undergoing preoperative chemo(radio)therapy for OC...
December 2, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29186308/predicting-forearm-physical-exposures-during-computer-work-using-self-reports-software-recorded-computer-usage-patterns-and-anthropometric-and-workstation-measurements
#9
Maaike A Huysmans, Belinda H W Eijckelhof, Jennifer L Bruno Garza, Pieter Coenen, Birgitte M Blatter, Peter W Johnson, Jaap H van Dieën, Allard J van der Beek, Jack T Dennerlein
Objectives: Alternative techniques to assess physical exposures, such as prediction models, could facilitate more efficient epidemiological assessments in future large cohort studies examining physical exposures in relation to work-related musculoskeletal symptoms. The aim of this study was to evaluate two types of models that predict arm-wrist-hand physical exposures (i.e. muscle activity, wrist postures and kinematics, and keyboard and mouse forces) during computer use, which only differed with respect to the candidate predicting variables; (i) a full set of predicting variables, including self-reported factors, software-recorded computer usage patterns, and worksite measurements of anthropometrics and workstation set-up (full models); and (ii) a practical set of predicting variables, only including the self-reported factors and software-recorded computer usage patterns, that are relatively easy to assess (practical models)...
November 25, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29179631/bulimic-symptomatology-among-male-collegiate-athletes-a-test-of-an-etiological-model
#10
Justine Chatterton, Trent A Petrie, Keke L Schuler, Camilo Ruggero
We tested Petrie and Greenleaf's psychosocial model in relation to male athletes' bulimic symptomatology. Through structural equation modeling, we cross-sectionally examined the direct and indirect effects of general and sport-specific appearance pressures, internalization, body satisfaction, drive for muscularity, negative affect, and dietary restraint on bulimic symptomatology. Participants were U.S. male collegiate athletes (N = 698; Mage = 19.87 years) representing 17 sports. With minor respecifications, the model had acceptable fit, and the psychosocial variables explained 48% of the bulimic symptomatology variance...
November 28, 2017: Journal of Sport & Exercise Psychology
https://www.readbyqxmd.com/read/29163111/association-between-slip-severity-and-muscle-synergies-of-slipping
#11
Mohammad Moein Nazifi, Kurt E Beschorner, Pilwon Hur
Falls impose significant negative impacts to the US population and economy. A significant number of falls may be prevented via appropriate slip-responses since a strong relation exists between slips and falls. More importantly, as severe slips are more prone to result in a fall, identifying severe slippers along with the responsible factors for their adverse motor control and severe slipping should be the highest priority in fall prevention process. Previous studies have suggested that muscle synergies may be building blocks of the central nervous system in controlling motor tasks...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29160161/serum-from-differently-exercised-subjects-induces-myogenic-differentiation-in-lhcn-m2-human-myoblasts
#12
D Vitucci, E Imperlini, R Arcone, A Alfieri, A Canciello, L Russomando, D Martone, A Cola, G Labruna, S Orrù, D Tafuri, A Mancini, P Buono
Myogenesis is the formation of muscle tissue from muscle precursor cells. Physical exercise induces satellite cell activation in muscle. Currently, C2C12 murine myoblast cells are used to study myogenic differentiation. Herein, we evaluated whether human LHCN-M2 myoblasts can differentiate into mature myotubes and express early (myotube formation, creatine kinase activity and myogenin) and late (MyHC-β) muscle-specific markers when cultured in differentiation medium (DM) for 2, 4 and 7 days. We demonstrate that treatment of LHCN-M2 cells with DM supplemented with 0...
November 21, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29144742/successful-identification-of-cardiac-troponin-calcium-sensitizers-using-a-combination-of-virtual-screening-and-roc-analysis-of-known-troponin-c-binders
#13
Melanie L Aprahamian, Svetlana B Tikunova, Morgan V Price, Andres F Cuesta, Jonathan P Davis, Steffen Lindert
Calcium-dependent cardiac muscle contraction is regulated by the protein complex troponin. Calcium binds to the N-terminal domain of troponin C (cNTnC) which initiates the process of contraction. Heart failure is a consequence of a disruption of this process. With the prevalence of this condition, a strong need exists to find novel compounds to increase the calcium sensitivity of cNTnC. Desirable are small chemical molecules that bind to the interface between cTnC and the cTnI switch peptide and exhibit calcium sensitizing properties by possibly stabilizing cTnC in an open conformation...
November 16, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29144584/3d-printed-anchoring-sutures-for-permanent-shaping-of-tissues
#14
Wei Wei, Yuxiao Li, Huazhe Yang, Reza Nassab, Fatemeh Shahriyari, Ali Akpek, Xiaofei Guan, Yanhui Liu, Shahrouz Taranejoo, Ali Tamayol, Yu Shrike Zhang, Ali Khademhosseini, Hae Lin Jang
Sutures are one of the most widely used devices for adhering separated tissues after injury or surgery. However, most sutures require knotting, which can create a risk of inflammation, and can act as mechanically weak points that often result in breakage and slipping. Here, an anchoring suture is presented with a design that facilitates its propagation parallel to the suturing direction, while maximizing its resistive force against the opposite direction of external force to lock its position in tissues. Different microstructures of suture anchors are systematically designed using orthogonal arrays, and selected based on shape factors associated with mechanical strength...
November 16, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29140269/the-prevalence-of-dietary-supplement-use-among-college-students-a-nationwide-survey-in-japan
#15
Etsuko Kobayashi, Yoko Sato, Keizo Umegaki, Tsuyoshi Chiba
To clarify the prevalence of dietary supplement use among college students, we conducted Internet-based nationwide questionnaire surveys with 157,595 Japanese college students aged between 18 to 24 years old who were registrants of Macromill Inc. (Tokyo, Japan). Among the 9066 respondents (response rate 5.8%), 16.8% were currently using dietary supplements. The prevalence of dietary supplement use did not differ significantly between males (17.1%) and females (16.7%). However, it increased according to their grade (13...
November 15, 2017: Nutrients
https://www.readbyqxmd.com/read/29140146/awareness-and-attitude-towards-use-of-dietary-supplements-and-the-perceived-outcomes-among-saudi-adult-male-members-of-fitness-centers-in-saudi-arabia
#16
Hanan A Alfawaz, Soundararajan Krishnaswamy, Latifah Al-Faifi, Halima Ali Bin Atta, Mohammad Al-Shayaa, Saad A Alghanim, Nasser M Al-Daghri
Dietary supplements are believed to enhance athletic performance and/or prevent/reverse pathological states. Despite the increasing use of dietary supplements in Saudi Arabia, systematic studies in this field are lacking. This study aims to assess the relation between demographic and social characteristics and dietary supplement use among adult males in Saudi Arabia. Demographic and dietary supplements data from fitness club participants were collected through a questionnaire and Pearson Chi-square test was used to determine associations...
November 15, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29138687/analysis-of-the-biceps-brachii-muscle-by-varying-the-arm-movement-level-and-load-resistance-band
#17
Nuradebah Burhan, Mohammad 'Afif Kasno, Rozaimi Ghazali, Md Radzai Said, Shahrum Shah Abdullah, Mohd Hafiz Jali
Biceps brachii muscle illness is one of the common physical disabilities that requires rehabilitation exercises in order to build up the strength of the muscle after surgery. It is also important to monitor the condition of the muscle during the rehabilitation exercise through electromyography (EMG) signals. The purpose of this study was to analyse and investigate the selection of the best mother wavelet (MWT) function and depth of the decomposition level in the wavelet denoising EMG signals through the discrete wavelet transform (DWT) method at each decomposition level...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29133824/comparison-and-evaluation-of-two-different-methods-to-establish-the-cigarette-smoke-exposure-mouse-model-of-copd
#18
Jiaze Shu, Defu Li, Haiping Ouyang, Junyi Huang, Zhen Long, Zhihao Liang, Yuqin Chen, Yiguan Chen, Qiuyu Zheng, Meidan Kuang, Haiyang Tang, Jian Wang, Wenju Lu
Animal model of cigarette smoke (CS) -induced chronic obstructive pulmonary disease (COPD) is the primary testing methodology for drug therapies and studies on pathogenic mechanisms of disease. However, researchers have rarely run simultaneous or side-by-side tests of whole-body and nose-only CS exposure in building their mouse models of COPD. We compared and evaluated these two different methods of CS exposure, plus airway Lipopolysaccharides (LPS) inhalation, in building our COPD mouse model. Compared with the control group, CS exposed mice showed significant increased inspiratory resistance, functional residual capacity, right ventricular hypertrophy index, and total cell count in BALF...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29127005/the-pleckstrin-homology-like-domain-family-member-tdag51-is-temporally-regulated-during-skeletal-muscle-regeneration
#19
Samantha K Coleman, Andrew W Cao, Irena A Rebalka, Gabriel Gyulay, Paige J Chambers, A Russell Tupling, Richard C Austin, Thomas J Hawke
The capacity for skeletal muscle to repair from daily insults as well as larger injuries is a vital component to maintaining muscle health over our lifetime. Given the importance of skeletal muscle for our physical and metabolic well-being, identifying novel factors mediating the growth and repair of skeletal muscle will thus build our foundational knowledge and help lead to potential therapeutic avenues for muscle wasting disorders. To that end, we investigated the expression of T-cell death associated gene 51 (TDAG51) during skeletal muscle repair and studied the response of TDAG51 deficient (TDAG51(-/-)) mice to chemically-induced muscle damage...
November 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29126250/diabetic-microvascular-disease-an-endocrine-society-scientific-statement
#20
Eugene J Barrett, Zhenqi Liu, Mogher Khamaisi, George L King, Ronald Klein, Barbara E K Klein, Timothy M Hughes, Suzanne Craft, Barry I Freedman, Donald W Bowden, Aaron I Vinik, Carolina M Casellini
Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our understanding of the genesis of this injury and of potential interventions to prevent, limit, or reverse injury/dysfunction is continuously evolving. This statement reviews biochemical/cellular pathways involved in facilitating and abrogating microvascular injury. The statement summarizes the types of injury/dysfunction that occur in the three classical diabetes microvascular target tissues, the eye, the kidney, and the peripheral nervous system; the statement also reviews information on the effects of diabetes and insulin resistance on the microvasculature of skin, brain, adipose tissue, and cardiac and skeletal muscle...
November 8, 2017: Journal of Clinical Endocrinology and Metabolism
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