keyword
MENU ▼
Read by QxMD icon Read
search

Muscle building

keyword
https://www.readbyqxmd.com/read/29144742/successful-identification-of-cardiac-troponin-calcium-sensitizers-using-a-combination-of-virtual-screening-and-roc-analysis-of-known-troponin-c-binders
#1
Melanie L Aprahamian, Svetlana B Tikunova, Morgan V Price, Andres F Cuesta, Jonathan P Davis, Steffen Lindert
Calcium-dependent cardiac muscle contraction is regulated by the protein complex troponin. Calcium binds to the N-terminal domain of troponin C (cNTnC) which initiates the process of contraction. Heart failure is a consequence of a disruption of this process. With the prevalence of this condition, a strong need exists to find novel compounds to increase the calcium sensitivity of cNTnC. Desirable are small chemical molecules that bind to the interface between cTnC and the cTnI switch peptide and exhibit calcium sensitizing properties by possibly stabilizing cTnC in an open conformation...
November 16, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29144584/3d-printed-anchoring-sutures-for-permanent-shaping-of-tissues
#2
Wei Wei, Yuxiao Li, Huazhe Yang, Reza Nassab, Fatemeh Shahriyari, Ali Akpek, Xiaofei Guan, Yanhui Liu, Shahrouz Taranejoo, Ali Tamayol, Yu Shrike Zhang, Ali Khademhosseini, Hae Lin Jang
Sutures are one of the most widely used devices for adhering separated tissues after injury or surgery. However, most sutures require knotting, which can create a risk of inflammation, and can act as mechanically weak points that often result in breakage and slipping. Here, an anchoring suture is presented with a design that facilitates its propagation parallel to the suturing direction, while maximizing its resistive force against the opposite direction of external force to lock its position in tissues. Different microstructures of suture anchors are systematically designed using orthogonal arrays, and selected based on shape factors associated with mechanical strength...
November 16, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29140269/the-prevalence-of-dietary-supplement-use-among-college-students-a-nationwide-survey-in-japan
#3
Etsuko Kobayashi, Yoko Sato, Keizo Umegaki, Tsuyoshi Chiba
To clarify the prevalence of dietary supplement use among college students, we conducted Internet-based nationwide questionnaire surveys with 157,595 Japanese college students aged between 18 to 24 years old who were registrants of Macromill Inc. (Tokyo, Japan). Among the 9066 respondents (response rate 5.8%), 16.8% were currently using dietary supplements. The prevalence of dietary supplement use did not differ significantly between males (17.1%) and females (16.7%). However, it increased according to their grade (13...
November 15, 2017: Nutrients
https://www.readbyqxmd.com/read/29140146/awareness-and-attitude-towards-use-of-dietary-supplements-and-the-perceived-outcomes-among-saudi-adult-male-members-of-fitness-centers-in-saudi-arabia
#4
Hanan A Alfawaz, Soundararajan Krishnaswamy, Latifah Al-Faifi, Halima Ali Bin Atta, Mohammad Al-Shayaa, Saad A Alghanim, Nasser M Al-Daghri
Dietary supplements are believed to enhance athletic performance and/or prevent/reverse pathological states. Despite the increasing use of dietary supplements in Saudi Arabia, systematic studies in this field are lacking. This study aims to assess the relation between demographic and social characteristics and dietary supplement use among adult males in Saudi Arabia. Demographic and dietary supplements data from fitness club participants were collected through a questionnaire and Pearson Chi-square test was used to determine associations...
November 15, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29138687/analysis-of-the-biceps-brachii-muscle-by-varying-the-arm-movement-level-and-load-resistance-band
#5
Nuradebah Burhan, Mohammad 'Afif Kasno, Rozaimi Ghazali, Md Radzai Said, Shahrum Shah Abdullah, Mohd Hafiz Jali
Biceps brachii muscle illness is one of the common physical disabilities that requires rehabilitation exercises in order to build up the strength of the muscle after surgery. It is also important to monitor the condition of the muscle during the rehabilitation exercise through electromyography (EMG) signals. The purpose of this study was to analyse and investigate the selection of the best mother wavelet (MWT) function and depth of the decomposition level in the wavelet denoising EMG signals through the discrete wavelet transform (DWT) method at each decomposition level...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29133824/comparison-and-evaluation-of-two-different-methods-to-establish-the-cigarette-smoke-exposure-mouse-model-of-copd
#6
Jiaze Shu, Defu Li, Haiping Ouyang, Junyi Huang, Zhen Long, Zhihao Liang, Yuqin Chen, Yiguan Chen, Qiuyu Zheng, Meidan Kuang, Haiyang Tang, Jian Wang, Wenju Lu
Animal model of cigarette smoke (CS) -induced chronic obstructive pulmonary disease (COPD) is the primary testing methodology for drug therapies and studies on pathogenic mechanisms of disease. However, researchers have rarely run simultaneous or side-by-side tests of whole-body and nose-only CS exposure in building their mouse models of COPD. We compared and evaluated these two different methods of CS exposure, plus airway Lipopolysaccharides (LPS) inhalation, in building our COPD mouse model. Compared with the control group, CS exposed mice showed significant increased inspiratory resistance, functional residual capacity, right ventricular hypertrophy index, and total cell count in BALF...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29127005/the-pleckstrin-homology-like-domain-family-member-tdag51-is-temporally-regulated-during-skeletal-muscle-regeneration
#7
Samantha K Coleman, Andrew W Cao, Irena A Rebalka, Gabriel Gyulay, Paige J Chambers, A Russell Tupling, Richard C Austin, Thomas J Hawke
The capacity for skeletal muscle to repair from daily insults as well as larger injuries is a vital component to maintaining muscle health over our lifetime. Given the importance of skeletal muscle for our physical and metabolic well-being, identifying novel factors mediating the growth and repair of skeletal muscle will thus build our foundational knowledge and help lead to potential therapeutic avenues for muscle wasting disorders. To that end, we investigated the expression of T-cell death associated gene 51 (TDAG51) during skeletal muscle repair and studied the response of TDAG51 deficient (TDAG51(-/-)) mice to chemically-induced muscle damage...
November 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29126250/diabetic-microvascular-disease-an-endocrine-society-scientific-statement
#8
Eugene J Barrett, Zhenqi Liu, Mogher Khamaisi, George L King, Ronald Klein, Barbara E K Klein, Timothy M Hughes, Suzanne Craft, Barry I Freedman, Donald W Bowden, Aaron I Vinik, Carolina M Casellini
Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our understanding of the genesis of this injury and of potential interventions to prevent, limit, or reverse injury/dysfunction is continuously evolving. This statement reviews biochemical/cellular pathways involved in facilitating and abrogating microvascular injury. The statement summarizes the types of injury/dysfunction that occur in the three classical diabetes microvascular target tissues, the eye, the kidney, and the peripheral nervous system; the statement also reviews information on the effects of diabetes and insulin resistance on the microvasculature of skin, brain, adipose tissue, and cardiac and skeletal muscle...
November 8, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29119105/a-rare-variant-in-pgap2-causes-autosomal-recessive-hyperphosphatasia-with-mental-retardation-syndrome-with-a-mild-phenotype-in-heterozygous-carriers
#9
Yonatan Perez, Ohad Wormser, Yair Sadaka, Ruth Birk, Ginat Narkis, Ohad S Birk
Mutations in genes involved in the biosynthesis of the glycosylphosphatidylinositol (GPI) anchor cause autosomal recessive glycosylation defects, with a wide phenotypic spectrum of intellectual disability, seizures, minor facial dysmorphism, hypotonia, and elevated serum alkaline phosphatase. We now describe consanguineous Bedouin kindred presenting with an autosomal recessive syndrome of intellectual disability and elevated serum alkaline phosphatase. Genome-wide linkage analysis identified 6 possible disease-associated loci...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29108034/genetic-evaluation-for-birth-and-conformation-traits-in-dual-purpose-belgian-blue-cattle-using-a-mixed-inheritance-model
#10
R R Mota, P Mayeres, C Bastin, G Glorieux, C Bertozzi, S Vanderick, H Hammami, F G Colinet, N Gengler
The segregation of the causal mutation () in the muscular hypertrophy gene in dual-purpose Belgian Blue (dpBB) cattle is considered to result in greater calving difficulty (dystocia). Establishing adapted genetic evaluations might overcome this situation through efficient selection. However, the heterogeneity of dpBB populations at the locus implies separating the major gene and other polygenic effects in complex modeling. The use of mixed inheritance models may be an interesting option because they simultaneously assume both influences...
October 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/29080065/effects-of-respiratory-muscle-training-rmt-in-patients-with-mild-to-moderate-obstructive-sleep-apnea-osa
#11
Simon Dominik Herkenrath, Marcel Treml, Christina Priegnitz, Wolfgang Galetke, Winfried J Randerath
PURPOSE: Different forms of training focusing on the muscles of the upper airways showed limited effects on obstructive sleep apnea (OSA) and/or snoring. We investigated the effect of generalized respiratory muscle training (RMT) in lean patients with mild to moderate OSA. METHODS: Nine male subjects (52.0 ± 10.8 years, BMI 29.1 ± 2.1 kg/m(2)) with obstructive sleep apnea (apnea-hypopnea index (AHI) 9-29) participated in an open, single-arm pilot study. After a 1-week build-up phase, patients underwent 4 weeks of normocapnic hyperpnea RMT five times a week for 30 min each...
October 28, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29073175/dissociation-between-behavior-and-motor-cortical-excitability-before-and-during-ballistic-wrist-flexion-and-extension-in-young-and-old-adults
#12
Tibor Hortobágyi, Adinda Mieras, John Rothwell, Miguel Fernandez Del Olmo
PURPOSE: Aging is associated with slow reactive movement generation and poor termination. OBJECTIVE: We examined the hypothesis that the build-up of excitability in the primary motor cortex in the agonist muscle to generate ballistic wrist flexion and extension and in the antagonist to stop the movement, is lower and slower in old compared with young adults. METHODS: We measured the size of the motor potentials evoked (MEP) produced by transcranial magnetic stimulation (TMS), background integrated EMG (iEMG), and the MEP:iEMG ratio in healthy young (23 y, n = 14) and old adults' (73 y, n = 14) wrist flexors and extensors as they rapidly flexed or extended the wrist in response to an auditory cue...
2017: PloS One
https://www.readbyqxmd.com/read/29070590/modelling-the-effects-of-short-and-random-proto-neural-elongations
#13
Oltman O de Wiljes, R A J van Elburg, Fred A Keijzer
To understand how neurons and nervous systems first evolved, we need an account of the origins of neural elongations: why did neural elongations (axons and dendrites) first originate, such that they could become the central component of both neurons and nervous systems? Two contrasting conceptual accounts provide different answers to this question. Braitenberg's vehicles provide the iconic illustration of the dominant input-output (IO) view. Here, the basic role of neural elongations is to connect sensors to effectors, both situated at different positions within the body...
October 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29069985/neural-autoantibodies-in-patients-with-neurological-symptoms-and-histories-of-chemical-mold-exposures
#14
Mohamed Bahie Abou-Donia, Allan Lieberman, Luke Curtis
A number of studies have linked exposures to industrial and household chemicals and biological toxins to increased risk of autoimmunity in general and elevated levels of autoantibodies to neural antigens specifically. Elevated neural autoantibodies are biomarkers for many diseases such as multiple sclerosis and Parkinson's disease. Our study reports levels of six types of neural autoantibodies in a group of 24 toxicant-exposed patients. The patients were exposed to a variety of toxicants including contaminated drinking water (four patients), building water/mold damage (eight patients), pesticides (four patients), and other assorted toxic chemicals (eight patients)...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29067089/is-biological-repair-of-heart-on-the-horizon
#15
REVIEW
H R Ahmad, Satwat Hashmi
The stem cells keep us young by endogenously repairing us upon need. They do so bysmartly one step forward towards differentiation while another step backward to nurturethe undifferentiated stem cells. They are building blocks for every organ witha differential rate of repair of worn out tissues. Since stem cells can be cultured with a normal karyo type, they could be the ideal source for heart repair after myocardial infarction. As opposed to lower vertebrates and neonatal mice, cardiac regeneration in adult mammalian heart seems to be difficult to assess with a solid evidence of cytokinesis...
July 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29060408/features-selection-for-bayes-classification-of-prolonged-fatigue-on-rectus-femoris-muscle
#16
Fauzani N Jamaluddin, Siti A Ahmad, Samsul Bahari Mohd Noor, Wan Zuha Wan Hassan, Y Azhar
Sports training is very important to athletes in improving and maintaining their performances. It commonly involves high intensity exercise and requires longer time for fatigue to recover, compares to normal activity. During training, adequate rest is essential to allow recuperation and build body strength. Unfortunately, inadequate rest exposes the body to prolonged fatigue (PF). Hence, this condition needs to be managed accordingly to avoid chronic fatigue syndrome. Recent findings indicate that there are strong characteristics on surface EMG under PF conditions...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060198/subject-specific-shoulder-muscle-attachment-region-prediction-using-statistical-shape-models-a-validity-study
#17
Asma Salhi, Valerie Burdin, Tinashe Mutsvangwa, Sudesh Sivarasu, Sylvain Brochard, Bhushan Borotikar
Subject-specific musculoskeletal models can predict accurate joint and muscle biomechanics thereby helping clinicians and surgeons. Current modeling strategies do not incorporate accurate subject-specific muscle parameters. This study reports a statistical shape model (SSM) based method to predict subject-specific muscle attachment regions on shoulder bones and illustrates the concurrent validity of the predictions. Augmented SSMs of scapula and humerus bones were built using bone meshes and five muscle attachment (origin/insertion) regions which play important role in the shoulder motion and function...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059902/on-the-impact-of-spike-segmentation-on-motor-unit-identification-in-dynamic-surface-electromyograms
#18
V Glaser, A Holobar
We discuss the adaptation of preexisting Convolution Kernel Compensation (CKC) surface electromyogram (EMG) decomposition technique to dynamic muscle contractions. In particular, three different algorithms for segmentation of motor unit (MU) spike trains into MU firings are discussed and mutually compared on synthetic dynamic surface EMG. The first segmentation algorithm employs a priori knowledge of the regularity of MU firings. The second one builds on K-means classification of MU spikes, whereas the third one combines both the regularity of MU firings and the previously introduced Pulse-to-Noise Ratio (PNR)...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29030959/ipsc-derived-vascular-cell-spheroids-as-building-blocks-for-scaffold-free-biofabrication
#19
Leni Moldovan, April Barnard, Chang-Hyun Gil, Yang Lin, Maria B Grant, Mervin C Yoder, Nutan Prasain, Nicanor I Moldovan
Recently a protocol is established to obtain large quantities of human induced pluripotent stem cells (iPSC)-derived endothelial progenitors, called endothelial colony forming cells (ECFC), and of candidate smooth-muscle forming cells (SMFC). Here, the suitability for assembling in spheroids, and in larger 3D cell constructs is tested. iPSC-derived ECFC and SMFC are labeled with tdTomato and eGFP, respectively. Spheroids are formed in ultra-low adhesive wells, and their dynamic proprieties are studied by time-lapse microscopy, or by confocal microscopy...
October 14, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29021167/high-density-lipoprotein-delivered-after-myocardial-infarction-increases-cardiac-glucose-uptake-and-function-in-mice
#20
Sarah E Heywood, Adele L Richart, Darren C Henstridge, Karen Alt, Helen Kiriazis, Claire Zammit, Andrew L Carey, Helene L Kammoun, Lea M Delbridge, Medini Reddy, Yi-Ching Chen, Xiao-Jun Du, Christoph E Hagemeyer, Mark A Febbraio, Andrew L Siebel, Bronwyn A Kingwell
Protecting the heart after an acute coronary syndrome is a key therapeutic goal to support cardiac recovery and prevent progression to heart failure. A potential strategy is to target cardiac glucose metabolism at the early stages after ischemia when glycolysis is critical for myocyte survival. Building on our discovery that high-density lipoprotein (HDL) modulates skeletal muscle glucose metabolism, we now demonstrate that a single dose of reconstituted HDL (rHDL) delivered after myocardial ischemia increases cardiac glucose uptake, reduces infarct size, and improves cardiac remodeling in association with enhanced functional recovery in mice...
October 11, 2017: Science Translational Medicine
keyword
keyword
74174
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"