Lucilla Crudele, Carlo De Matteis, Giusi Graziano, Fabio Novielli, Stefano Petruzzelli, Elena Piccinin, Raffaella Maria Gadaleta, Marica Cariello, Antonio Moschetta
Non-alcoholic fatty liver disease (NAFLD), specifically liver steatosis and fibrosis with steatohepatitis (NASH), is often associated with visceral adiposopathy, whose pathogenetic features have been proposed as tumorigenic triggers. We performed a prospective analysis in 653 metabolic women to reveal any conditions that may predict and concur to cancer development during a 8-years period of follow-up. Among clinical and biochemical variables, only AST and non-invasive liver fibrosis scores (AARPRI, APRI, FIB-4, mFIB4) significantly distinguished cancer-developer women (n = 62, 9...
October 18, 2023: Scientific Reports