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https://www.readbyqxmd.com/read/27894098/impact-of-mediterranean-diet-on-metabolic-syndrome-cancer-and-longevity
#1
Nicola Di Daniele, Annalisa Noce, Maria Francesca Vidiri, Eleonora Moriconi, Giulia Marrone, Margherita Annicchiarico-Petruzzelli, Gabriele D'Urso, Manfredi Tesauro, Valentina Rovella, Antonino De Lorenzo
Obesity symbolizes a major public health problem. Overweight and obesity are associated to the occurrence of the metabolic syndrome and to adipose tissue dysfunction. The adipose tissue is metabolically active and an endocrine organ, whose dysregulation causes a low-grade inflammatory state and ectopic fat depositions. The Mediterranean Diet represents a possible therapy for metabolic syndrome, preventing adiposopathy or "sick fat" formation.The Mediterranean Diet exerts protective effects in elderly subjects with and without baseline of chronic diseases...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27683789/tendinopathy-and-obesity
#2
Adham do Amaral E Castro, Thelma Larocca Skare, Paulo Afonso Nunes Nassif, Alexandre Kaue Sakuma, Wagner Haese Barros
Introduction: Tendinopathies and tendon tears account for over 30% of all musculoskeletal consultations. Obesity, which is becoming one of the world´s most prevalent public health issues, may be associated with this condition. Objective: To review the literature about tendinopathies and obesity association. Methods: This is a descriptive exploratory study using the portal Medline. Literature in English language from 2006 to 2014 were reviewed...
2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27490249/the-homa-adiponectin-homa-ad-closely-mirrors-the-homa-ir-index-in-the-screening-of-insulin-resistance-in-the-brazilian-metabolic-syndrome-study-brams
#3
Brunna Sullara Vilela, Ana Carolina Junqueira Vasques, Roberta Soares Lara Cassani, Adriana Costa E Forti, José Carlos Pareja, Marcos Antonio Tambascia, Bruno Geloneze
BACKGROUND: The major adverse consequences of obesity are associated with the development of insulin resistance (IR) and adiposopathy. The Homeostasis Model Assessment-Adiponectin (HOMA-AD) was proposed as a modified version of the HOMA1-IR, which incorporates adiponectin in the denominator of the index. OBJECTIVES: To evaluate the performance of the HOMA-AD index compared with the HOMA1-IR index as a surrogate marker of IR in women, and to establish the cutoff value of the HOMA-AD...
2016: PloS One
https://www.readbyqxmd.com/read/27487522/secretory-function-of-adipose-tissue
#4
J Kuryszko, P Sławuta, G Sapikowski
There are two kinds of adipose tissue in mammals: white adipose tissue - WAT and brown adipose tissue - BAT. The main function of WAT is accumulation of triacylglycerols whereas the function of BAT is heat generation. At present, WAT is also considered to be an endocrine gland that produces bioactive adipokines, which take part in glucose and lipid metabolism. Considering its endocrine function, the adipose tissue is not a homogeneous gland but a group of a few glands which act differently. Studies on the secretory function of WAT began in 1994 after discovery of leptin known as the satiation hormone, which regulates body energy homeostasis and maintainence of body mass...
2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27375553/the-role-of-gut-microflora-and-the-cholinergic-anti-inflammatory-neuroendocrine-system-in-diabetes-mellitus
#5
REVIEW
Parth J Parekh, Vipul R Nayi, David A Johnson, Aaron I Vinik
The obesity epidemic has drastically impacted the state of health care in the United States. Paralleling this epidemic is the incidence of diabetes mellitus, with a notable shift toward a much younger age of onset. While central to the pathogenesis of diabetes associated with obesity is the role of inflammation attributed to "adiposopathy." Emerging data suggest that changes in sympathetic/parasympathetic balance regulated by the brain precede changes in the inflammatory cascade. It has now been established that the gut microflora contributes significantly to the activation and inhibition of autonomic control and impact the set of the neuroinflammatory inhibitory reflex mediated by the cholinergic nervous system...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27139423/fitness-adiposopathy-and-adiposity-are-independent-predictors-of-insulin-sensitivity-in-middle-aged-men-without-diabetes
#6
Claire Huth, Étienne Pigeon, Marie-Ève Riou, Josée St-Onge, Hélène Arguin, Erick Couillard, Marie-Julie Dubois, André Marette, Angelo Tremblay, S John Weisnagel, Michel Lacaille, Pascale Mauriège, Denis R Joanisse
Adiposopathy, or sick fat, refers to adipose tissue dysfunction that can lead to several complications such as dyslipidemia, insulin resistance, and hyperglycemia. The relative contribution of adiposopathy in predicting insulin resistance remains unclear. We investigated the relationship between adiposopathy, as assessed as a low plasma adiponectin/leptin ratio, with anthropometry, body composition (hydrostatic weighing), insulin sensitivity (hyperinsulinemic-euglycemic clamp), inflammation, and fitness level (ergocycle VO2max, mL/kgFFM/min) in 53 men (aged 34-53 years) from four groups: sedentary controls without obesity (body mass index [BMI] <25 kg/m(2)), sedentary with obesity (BMI > 30 kg/m(2)), sedentary with obesity and glucose intolerance, and endurance trained active without obesity...
September 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27043550/diet-microbiota-obesity-and-nafld-a-dangerous-quartet
#7
REVIEW
Mariana Verdelho Machado, Helena Cortez-Pinto
Recently, the importance of the gut-liver-adipose tissue axis has become evident. Nonalcoholic fatty liver disease (NAFLD) is the hepatic disease of a systemic metabolic disorder that radiates from energy-surplus induced adiposopathy. The gut microbiota has tremendous influences in our whole-body metabolism, and is crucial for our well-being and health. Microorganisms precede humans in more than 400 million years and our guest flora evolved with us in order to help us face aggressor microorganisms, to help us maximize the energy that can be extracted from nutrients, and to produce essential nutrients/vitamins that we are not equipped to produce...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26891998/national-lipid-association-annual-summary-of-clinical-lipidology-2016
#8
REVIEW
Harold E Bays, Peter H Jones, Carl E Orringer, W Virgil Brown, Terry A Jacobson
The National Lipid Association (NLA) Annual Summary of Clinical Lipidology is a yearly updated summary of principles important to the patient-centered evaluation, management, and care of patients with dyslipidemia. This summary is intended to be a "living document," with future annual updates based on emerging science, clinical considerations, and new NLA Position, Consensus, and Scientific Statements, thus providing an ongoing resource that applies the latest in medical science towards the clinical management of patients with dyslipidemia...
January 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/26811617/new-obesity-classification-criteria-as-a-tool-for-bariatric-surgery-indication
#9
REVIEW
Antonino De Lorenzo, Laura Soldati, Francesca Sarlo, Menotti Calvani, Nicola Di Lorenzo, Laura Di Renzo
Obesity plays relevant pathophysiological role in the development of health problems, arising as result of complex interaction of genetic, nutritional, and metabolic factors. Due to the role of adipose tissue in lipid and glucose metabolism, and low grade inflammation, it is necessary to classify obesity on the basis of body fat composition and distribution, rather than the simply increase of body weight, and the Body Mass Index. The new term of adiposopathy (''sick fat'') clearly defines the pathogenic role of adipose tissue...
January 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26353175/preface-to-special-issue-on-adiposopathy-in-cancer-and-cardio-metabolic-diseases-an-endocrine-approach-part-4
#10
EDITORIAL
Gérard S Chetrite, Bruno Fève
No abstract text is available yet for this article.
July 2015: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/26331354/adiposopathy-and-epigenetics-an-introduction-to-obesity-as-a-transgenerational-disease
#11
REVIEW
Harold Bays, Wendy Scinta
BACKGROUND: To examine the contribution of generational epigenetic dysregulation to the inception of obesity and its adiposopathic consequences. METHODS: Sources for this review included searches of PubMed, Google Scholar, and international government/major association websites using terms including adiposity, adiposopathy, epigenetics, genetics, and obesity. RESULTS: Excessive energy storage in adipose tissue often results in fat cell and fat organ dysfunction, which may cause metabolic and fat mass disorders...
November 2015: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/26154196/when-fat-becomes-an-ally-of-the-enemy-adipose-tissue-as-collaborator-in-human-breast-cancer
#12
REVIEW
Lore Lapeire, Hannelore Denys, Véronique Cocquyt, Olivier De Wever
Since the discovery of leptin in 1994, our vision of adipose tissue as a static organ regulating mainly lipid storage and release has been completely overthrown, and adipose tissue is now seen as an active and integral organ in human physiology. In the past years, extensive research has tremendously given us more insights in the mechanisms and pathways involved not only in normal but also in 'sick' adipose tissue, for example, in obesity and lipodystrophy. With growing evidence of a link between obesity and several types of cancer, research focusing on the interaction between adipose tissue and cancer has begun to unravel the interesting but complex multi-lateral communication between the different players...
July 2015: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/26057219/adiponectin-as-a-biomarker-linking-obesity-and-adiposopathy-to-hematologic-malignancies
#13
REVIEW
Maria Dalamaga, Gerasimos S Christodoulatos
Higher body mass index and adiposopathy have been associated with increased risk of hematologic malignancies such as leukemia, multiple myeloma, myeloproliferative disorders, Hodgkin's and non-Hodgkin's lymphoma, and myelodysplastic syndromes. Adiponectin is a multimeric protein of the white adipose tissue presenting anti-inflammatory, insulin-sensitizing, anti-atherogenic, cardioprotective, and anti-neoplastic properties. Its anti-neoplastic actions are manifested via two mechanisms: (i) direct action on tumor cells by enhancing receptor-mediated signaling pathways and (ii) indirect action by regulating inflammatory responses, influencing cancer angiogenesis, and modulating insulin sensitivity at the target tissue site...
July 2015: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/26041698/intermuscular-and-perimuscular-fat-expansion-in-obesity-correlates-with-skeletal-muscle-t-cell-and-macrophage-infiltration-and-insulin-resistance
#14
I M Khan, X Yd Perrard, G Brunner, H Lui, L M Sparks, S R Smith, X Wang, Z-Z Shi, D E Lewis, H Wu, C M Ballantyne
BACKGROUND/OBJECTIVES: Limited numbers of studies demonstrated obesity-induced macrophage infiltration in skeletal muscle (SM), but dynamics of immune cell accumulation and contribution of T cells to SM insulin resistance are understudied. SUBJECTS/METHODS: T cells and macrophage markers were examined in SM of obese humans by reverse transcription-PCR (RT-PCR). Mice were fed high-fat diet (HFD) for 2-24 weeks, and time course of macrophage and T-cell accumulation was assessed by flow cytometry and quantitative RT-PCR...
November 2015: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/26011938/preface-to-special-issue-on-adiposopathy-in-cancer-and-cardio-metabolic-diseases-an-endocrine-approach-part-3
#15
EDITORIAL
Gérard S Chetrite, Bruno Fève
No abstract text is available yet for this article.
April 2015: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/25816312/not-all-fats-are-created-equal-adipose-vs-ectopic-fat-implication-in-cardiometabolic-diseases
#16
REVIEW
Melania Gaggini, Chiara Saponaro, Amalia Gastaldelli
Adipose tissue is a recognized endocrine organ that acts not only as a fuel storage but also is able to secrete adipokines that can modulate inflammation. Most of the fat is composed of white adipocytes (WAT), although also brown/beige adipocytes (BAT/BeAT) have been found in humans. BAT is located close to the neck but also among WAT in the epicardial fat and perivascular fat. Adipocyte hypertrophy and infiltration of macrophages impair adipose tissue metabolism determining "adiposopathy" (i.e., sick fat) and increasing the risk to develop metabolic and cardiovascular diseases...
April 2015: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/25781557/visceral-adiposopathy-a-vascular-perspective
#17
REVIEW
Melissa G Farb, Noyan Gokce
Obesity has emerged as one of the most critical health care problems globally that is associated with the development of insulin resistance, type 2 diabetes mellitus, metabolic dysfunction and cardiovascular disease. Central adiposity with intra-abdominal deposition of visceral fat, in particular, has been closely linked to cardiometabolic consequences of obesity. Increasing epidemiological, clinical and experimental data suggest that both adipose tissue quantity and perturbations in its quality termed "adiposopathy" contribute to mechanisms of cardiometabolic disease...
February 2015: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/25781552/adipose-tissue-obesity-and-adipokines-role-in-cancer-promotion
#18
REVIEW
Andrea Booth, Aaron Magnuson, Josephine Fouts, Michelle Foster
Adipose tissue is a complex organ with endocrine, metabolic and immune regulatory roles. Adipose depots have been characterized to release several adipocytokines that work locally in an autocrine and paracrine fashion or peripherally in an endocrine fashion. Adipocyte hypertrophy and excessive adipose tissue accumulation, as occurs during obesity, dysregulates the microenvironment within adipose depots and systemically alters peripheral tissue metabolism. The term "adiposopathy" is used to describe this promotion of pathogenic adipocytes and associated adipose - elated disorders...
January 2015: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/25781551/local-adipocyte-cancer-cell-paracrine-loop-can-sick-fat-be-more-detrimental
#19
REVIEW
Marie-Christine Rio, Nassim Dali-Youcef, Catherine Tomasetto
This review article focuses on the emerging role of tumor resident adipocytes. It provides in vitro and in vivo evidence that they are essential for cancer development/progression. In addition to systemic effects, their tumor-promoting impact is dependent on local functions, notably via a complex adipocyte cancer cell paracrine loop (ACCPL). Indeed, this event leads to dramatic phenotypic and/or functional modifications of both cell types as well as of the extracellular matrix. Adipocytes undergo delipidation leading to adipocytes/cancer-associated adipocytes/cancer-associated fibroblasts de-differentiation processes...
January 2015: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/25781549/adiposopathy-in-cancer-and-cardio-metabolic-diseases-an-endocrine-approach-%C3%A2-part-2
#20
EDITORIAL
Gérard S Chetrite, Bruno Fève
No abstract text is available yet for this article.
January 2015: Hormone Molecular Biology and Clinical Investigation
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