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Synovial sarcoma foot

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https://www.readbyqxmd.com/read/27751846/safety-and-efficacy-of-regorafenib-in-patients-with-advanced-soft-tissue-sarcoma-regosarc-a-randomised-double-blind-placebo-controlled-phase-2-trial
#1
Olivier Mir, Thomas Brodowicz, Antoine Italiano, Jennifer Wallet, Jean-Yves Blay, François Bertucci, Christine Chevreau, Sophie Piperno-Neumann, Emmanuelle Bompas, Sébastien Salas, Christophe Perrin, Corinne Delcambre, Bernadette Liegl-Atzwanger, Maud Toulmonde, Sarah Dumont, Isabelle Ray-Coquard, Stéphanie Clisant, Sophie Taieb, Cécile Guillemet, Maria Rios, Olivier Collard, Laurence Bozec, Didier Cupissol, Esma Saada-Bouzid, Christine Lemaignan, Wolfgang Eisterer, Nicolas Isambert, Loïc Chaigneau, Axel Le Cesne, Nicolas Penel
BACKGROUND: Regorafenib is a multikinase inhibitor with proven activity in refractory gastrointestinal stromal tumours and chemotherapy-refractory advanced colorectal cancers. We assessed this agent's efficacy and safety in patients with metastatic soft tissue sarcomas previously treated with anthracycline. METHODS: In this randomised, double-blind, phase 2 trial undertaken in France and Austria, we enrolled patients aged 18 years and older with advanced soft tissue sarcomas who had received previous doxorubicin or other anthracycline treatment...
October 14, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27587379/what-factors-are-predictive-of-outcome-in-the-treatment-of-soft-tissue-sarcomas-of-the-foot-and-ankle
#2
Matthew T Houdek, Taylor R Beahrs, Cody C Wyles, Peter S Rose, Franklin H Sim, Norman S Turner
: Soft tissue sarcomas of the foot and ankle are common. Currently, there exist limited data on prognostic variables. The aim of this study was to review our institution's experience with soft tissue sarcomas of the foot and ankle to identify factors affecting outcomes and survivorship. We reviewed the records of 62 foot and ankle soft tissue sarcomas treated with definitive surgery at our institution between 1992 and 2013. The cohort consisted of 35 males and 27 females with a mean age at diagnosis of 45 years and a mean follow-up of 7 years...
September 1, 2016: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/27489968/synovial-sarcoma-in-the-foot-of-a-5-year-old-childa-case-report
#3
Gary M Lepow, Daniel L Grimmer, Onya V Lemar, Evan A Bridges
The purpose of this case report is to present a rare finding of synovial sarcoma in a 5-year-old child. Most soft-tissue masses of the foot are too often presumed to be small and benign; therefore, compared with soft-tissue sarcomas, they are difficult to clinically differentiate and treat. A 5-year-old girl presented with a painful lesion that was diagnosed as synovial sarcoma after an excisional biopsy was performed. This was an unexpected finding of synovial sarcoma involving the tibialis posterior tendon of her right foot...
July 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/25838161/midfoot-reconstruction-with-serratus-anterior-rib-osteomuscular-free-flap-following-oncological-resection-of-synovial-sarcoma
#4
Bruno Battiston, Stefano Artiaco, Raimondo Piana, Elena Boux, Pierluigi Tos
During recent decades, the concept of surgical treatment of malignant bone and soft tissue sarcomas has evolved, with the aim of preserving limb function. In this paper we report a case of metatarsal reconstruction by means of serratus and rib free flap after excision of a synovial sarcoma located in the dorsal aspect of the midfoot. Five years after the operation, the patient was free from recurrence and recovered full foot function. Amputation has been widely used in the past and this procedure still remains a valuable option when limb salvage is not possible...
December 2015: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/25207328/prevalence-of-malignant-soft-tissue-tumors-in-extremities-an-epidemiological-study-in-syria
#5
Habib Reshadi, Alireza Rouhani, Saeid Mohajerzadeh, Marvan Moosa, Asghar Elmi
BACKGROUND: Although the majority of soft tissue masses are benign, it is important to consider malignancy in differential diagnoses. Because most soft tissue sarcomas present as a painless mass, clinicians must watch for signs suggestive of malignancy, including large size, rapid growth, and site deep into the deep fascia. The purpose of this study was to determine the relative prevalence according to sex and age, site of tumor, skeletal distribution, and treatment (surgery, chemotherapy and radiotherapy) before and after surgery, and ascertain the relative frequency of these tumors in specific anatomic sites and age groups based on pathological studies...
June 2014: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/25031505/clinicopathological-features-diagnosis-and-treatment-of-clear-cell-sarcoma-melanoma-of-soft-parts
#6
REVIEW
Af Mavrogenis, G Bianchi, Na Stavropoulos, Pj Papagelopoulos, P Ruggieri
Clear cell sarcoma of tendons and aponeuroses is a rare, high grade malignant soft tissue tumor resembling melanoma and soft tissue sarcomas. Clinical and Imaging Presentation: The median age at presentation is 27 years and the most common location are the foot and the ankle. MR imaging typically shows a benign looking, well defined, homogenous mass; on T1-weighted MR images, it is usually homogeneous and isointense or slight hyperintense to muscle, whereas on T2-weighted MR images, it is usually more heterogeneous with variable signal intensity...
October 2013: Hippokratia
https://www.readbyqxmd.com/read/24957508/reverse-sural-fasciocutaneous-flap-with-a-cutaneous-pedicle-to-cover-distal-lower-limb-soft-tissue-defects-experience-of-109-clinical-cases
#7
Anoop C Dhamangaonkar, Hemant S Patankar
BACKGROUND: Soft tissue defects over the mid- and distal third tibia, heel, dorsum and plantar aspect of the foot and over the medial, lateral and posterior aspect of the ankle are a common scenario in clinical orthopaedic practice. In this article, we describe the utility of the reverse sural fasciocutaneous flap with a cutaneous pedicle in 109 clinical cases with distal lower limb soft tissue defects. MATERIALS AND METHODS: A total of 109 patients were operated on for moderate (5-15 cm) and large (more than 15 cm) soft tissue defects at various sites along the lower limb including foot, heel and sole with the reverse sural fasciocutaneous flap...
September 2014: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/23657049/the-split-radial-forearm-flap-for-lower-leg-defects
#8
Robert J van Kampen, Eveline M L Corten, Pascal P A Schellekens
The conventional free radial forearm flap is a very reliable, long-pedicled flap with thin, pliable skin. These properties make it an excellent choice for high-risk reconstructions or defects requiring only a thin cover. The split radial forearm flap allows primary closure of the donor site and has a large variability in shape and size. In this report, the cutaneous perforators of the radial artery were investigated in fresh cadavers and we present our clinical experience with the split radial artery flap in 9 patients with lower leg defects...
November 2014: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/23632071/synovial-sarcoma-of-the-foot
#9
Mikhail Bekarev, Elisabeth C Elsinger, Esperanza Villanueva-Siles, Ross M Borzykowski, David S Geller
We report the case of a 75-year-old male who underwent lung lobectomy for presumed lung cancer. Thereafter, he presented with a painful mass between the third and fourth metatarsal heads in the foot that was assumed to be Morton's neuroma. After extensive oncologic evaluation, the foot mass was diagnosed as a synovial sarcoma. In retrospect, his lung lesion was understood to be metastatic disease.
July 2013: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/22802558/giant-cell-tumour-of-peroneus-brevis-tendon-sheath-a-case-report-and-review-of-literature
#10
REVIEW
Vijay Goni, Nirmal Raj Gopinathan, B D Radotra, Vibhu Krishnan Viswanathan, Rajesh Kumar Logithasan, Balaji S
Giant cell tumour of tendon sheath is a benign soft tissue lesion most commonly found in the flexor aspect of hand and wrist. Being rare in foot and ankle, the unusual presentation of this lesion may sometimes mimic other lesions like lipoma, synovial sarcoma, malignant fibrous histiocytoma, synovial cyst and ganglion. Hence it is important to include this lesion in differential diagnoses especially if the lesion is found to be anchored to any of the surrounding tendons. This article describes the unusual occurrence of giant cell tumour of the tendon sheath of peroneus brevis which is rarely described in literature...
2012: BMJ Case Reports
https://www.readbyqxmd.com/read/22530463/synovial-sarcoma-of-the-foot-enlightening-etiology-a-case-report
#11
Nanze Yu, Feng Cheng, Luwei Xiao, Peijan Tong, Changxing Wang
Synovial sarcoma which mainly affects the periarticular tissues of the extremities in young adults is an uncommon seen soft tissue sarcoma with uncertain causative factors. We report a long-course primary synovial sarcoma of the left foot in a 46-year-old man. The initial symptom occurred when he was 26-year-old. During these 20 years, he underwent two operations, with the diagnosis of synovial cyst and nodular synovitis. This time, a lobulated 7 x 5.5 x 6 cm mass was found on computed tomography, and a final diagnosis of synovial sarcoma was made by histological study...
December 2010: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/22216384/soft-tissue-chondroma-a-case-report-and-literature-review
#12
Moosa Bahnassy, Hala Abdul-Khalik
Extra skeletal soft tissue chondroma is a very rare, slow progressing, benign tumor. It has a specific tendency for hands and feet. It can sometimes be misdiagnosed as a synovial cyst or a more serious condition such as synovial sarcoma. Moreover, it can exhibit worrying radiologic and histological features mimicking chondrosarcomas. This study presents a very rare case of soft tissue chondroma of the foot.
October 2009: Oman Medical Journal
https://www.readbyqxmd.com/read/22187851/midfoot-reconstruction-with-free-vascularized-fibular-graft-after-wide-resection-a-case-report
#13
Harzem Ozger, Turgut Akgül, Ilker Eren, Murat Topalan
Malignant foot tumours are often treated with amputations due to anatomical difficulties. Limb salvage techniques are difficult to perform, as a stable, sensible and plantigrade foot should be obtained to prevent further problems.In this report, we present a midfoot reconstruction with a vascularized free fibula, osteomized in a V-shape after wide resection of a midfoot synovial sarcoma. We describe the reconstruction of both longitudinal arches in which using a vascularized autograft facilitated union, remodeling of the bone, and obtaining a functional foot...
October 2011: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/22142486/the-adverse-effect-of-an-unplanned-surgical-excision-of-foot-soft-tissue-sarcoma
#14
Akinobu Nishimura, Akihiko Matsumine, Kunihiro Asanuma, Takao Matsubara, Tomoki Nakamura, Atsumasa Uchida, Ko Kato, Akihiro Sudo
BACKGROUND: Malignant soft tissue tumors of the foot are extremely rare and thus can be prematurely excised without appropriate preoperative evaluation. The present study compares adverse effects between unplanned and planned surgical excisions. METHODS: We retrospectively reviewed the clinical records, radiographs, pathology reports and pathological specimens of 14 consecutive patients with soft tissue sarcoma of the foot among 592 with sarcomas between 1973 and 2009...
2011: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/22055401/inhibin-%C3%AE-and-synaptophysin-immunoreactivity-in-synovial-sarcoma-with-granular-cell-features
#15
Nokitaka Setsu, Kenichi Kohashi, Makoto Endo, Hidetaka Yamamoto, Yoshihiro Ohishi, Kazunobu Sueyoshi, Yukihide Iwamoto, Masazumi Tsuneyoshi, Toru Motoi, Arisa Kumagai, Yoshinao Oda
We recognized immunoreactivity for the α subset of inhibin and synaptophysin in synovial sarcomas with granular cell features. Histologic findings of 90 cases of synovial sarcoma were reviewed. Two (2.2%) of the 90 cases had granular cell features, showing sheet or nested proliferation of characteristic epithelioid cells with abundant eosinophilic and granular cytoplasm, in addition to the typical spindle cell component. The 2 cases were both female (aged 86 and 76 years). The tumors were located in the foot and the retroperitoneum and measured 3...
June 2012: Human Pathology
https://www.readbyqxmd.com/read/22009971/synovial-sarcoma-of-the-foot-a-case-report
#16
Nan-Ze Yu, Feng Cheng, Hong-Ting Jin, Lu-Wei Xiao, Pei-Jian Tong, Chang-Xing Wang
No abstract text is available yet for this article.
November 2010: Orthopaedic Surgery
https://www.readbyqxmd.com/read/21817009/small-blue-round-cell-tumor-an-unusual-case-presentation-in-the-foot
#17
REVIEW
J Marshall Devall, Katherine M Frush, Lori Steiner
Small blue round cell tumors of childhood rarely present in the foot or ankle. The following is a case presentation of an 18-year-old male with a large soft-tissue mass of the foot with associated lung metastasis. A definitive diagnosis could not be fully made, even with immunohistochemical and genetic testing. Diagnosis favored poorly differentiated synovial sarcoma.
July 2011: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/21616683/mycetoma-or-synovial-sarcoma-a-case-report-with-review-of-the-literature
#18
REVIEW
A Louis Jimenez, Nichol L Salvo
Mycetoma, also commonly referred to as Madura foot, is statistically rare in the United States. However, it is endemic to other parts of the world. It is a pseudotumor characterized by a triad of tumefaction, draining sinuses, and grains. Two types exist, with each caused by different groups of organisms that require different treatment approaches. Therefore, the exact diagnosis and culture of the organism is vital to successful treatment outcomes. Synovial sarcoma, in contrast, is a malignancy much more commonly seen in the United States...
September 2011: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/21172645/synovial-sarcoma-arising-in-the-foot-case-report
#19
Steven F Boc, Sharmila Das-Wattley, Eric Roberts
Synovial sarcomas occur primarily in the soft tissue structures adjacent to the joints and tendons of the extremities. A diagnostic dilemma exists when the clinical presentation is similar to that of an infection or soft tissue trauma. We report a case of soft tissue sarcoma of the foot in a previously healthy 19-year-old male who presented after hitting his right foot against a refrigerator. Initial radiographs were negative; however, 6 weeks later plain radiographs revealed destruction of the metatarsals...
January 2011: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/21092437/case-series-soft-tissue-sarcoma-of-the-foot
#20
L Daniel Latt, Robert E Turcotte, Marc H Isler, Cynthia Wong
BACKGROUND: We reviewed cases of soft-tissue sarcoma of the foot to gain insight into the presentation, treatments and outcomes for this rare disease and to determine whether limb-salvage surgery yields reasonable functional and oncological outcomes. METHODS: We reviewed the cases of 16 patients treated by 2 of us (R.T. and M.I.) for soft-tissue sarcoma of the foot over a 15-year period. We extracted the following information from each patient's medical record: disease status at presentation, prior treatment, histological diagnosis, American Joint Committee on Cancer (AJCC) stage, details of treatment, oncological outcome and functional outcome...
December 2010: Canadian Journal of Surgery. Journal Canadien de Chirurgie
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