Yendubé T Kantati, Magloire K Kodjo, Benjamin Lefranc, Magali Basille-Dugay, Sébastien Hupin, Isabelle Schmitz, Jérôme Leprince, Messanvi Gbeassor, David Vaudry
Plants are a valuable source of information for pharmacological research and new drug discovery. The present study aimed to evaluate the neuroprotective potential of the leaves of the medicinal plant Sterculia setigera. In vitro, the effect of Sterculia setigera leaves dry hydroethanolic extract (SSE) was tested on cultured cerebellar granule neurons (CGN) survival when exposed to hydrogen peroxide (H2 O2 ) or 6-hydroxydopamine (6-OHDA), using the viability probe fluorescein diacetate (FDA), a lactate dehydrogenase (LDH) activity assay, an immunocytochemical staining against Gap 43, and the quantification of the expression of genes involved in apoptosis, necrosis, or oxidative stress...
April 17, 2024: Journal of Molecular Neuroscience: MN