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https://www.readbyqxmd.com/read/29164806/enhanced-cytotoxicity-and-apoptosis-by-raloxifene-in-combination-with-estrogen-and-methotrexate-in-human-endometrial-stromal-thesc-cells
#1
Ivana Nikolic, Marija Andjelkovic, Milan Zaric, Ivanka Zelen, Zoran Milosavljevic, Petar Canovic, Marina Mitrovic
Endometrial hyperplasia is a condition that may lead to the development of endometrial carcinoma. Initially, changes of the endometrium are caused by the estrogen's hyperstimulation that may lead to the development of an irregular bleeding and the infertility problems. Therapy of endometrial hyperplasia's is limited to medical and surgical approaches. During the past decade, the new types of drugs were developed for the treatment of the endometrial hyperplasia. Here, for the first time, we investigated the cytotoxic effects of the various combinations of estrogen, raloxifene and methotrexate in human ThESC cell line as a possible potential treatment of the endometrial hyperplasia...
November 22, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29161347/pharmacological-blockage-of-the-cxcr4-cxcl12-axis-in-endometriosis-leads-to-contrasting-effects-in-proliferation-migration-and-invasion
#2
Abigail Ruiz, Lynnette Ruiz, Mariano Colón-Caraballo, Bryan J Torres-Collazo, Janice B Monteiro, Manuel Bayona, Asgerally T Fazleabas, Idhaliz Flores
High levels of inflammatory factors including chemokines have been reported in peritoneal fluid and blood of women with endometriosis. CXCL12 mediates its action by interaction with its specific receptor, CXCR4, which has been reported to be elevated in human endometriosis lesions and in the rat model of endometriosis. Activation of the CXCR4-CXCL12 axis increases cell proliferation, migration and invasion of cancer cells. To obtain insights into the CXCR4 expression profile in lesions and endometrium, as well as functionality of the CXCR4-CXCL12 axis in endometriosis we analysed the expression of CXCR4 in tissues on a human tissue array and studied CXCL12-mediated activation of proliferation, invasion, and migration in vitro...
November 17, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29160590/corrigendum-expression-of-nad-p-h-quinone-dehydrogenase-1-nqo1-is-increased-in-the-endometrium-of-women-with-endometrial-cancer-and-women-with-polycystic-ovary-syndrome
#3
William Atiomo, Mohamad Nasir Shafiee, Caroline Chapman, Veronika M Metzler, Jad Abouzeid, Ayşe Latif, Amy Chadwick, Sarah Kitson, Vanitha N Sivalingam, Ian J Stratford, Catrin S Rutland, Jenny L Persson, Niels Ødum, Pablo Fuentes-Utrilla, Jennie N Jeyapalan, David M Heery, Emma J Crosbie, Nigel P Mongan
No abstract text is available yet for this article.
December 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29159661/safety-of-clomiphene-citrate-a-literature-review
#4
REVIEW
Serkan Yilmaz, Neslihan Yilmaz Sezer, İlknur Münevver Gönenç, Sibel Erkal İlhan, Ebru Yilmaz
Clomiphene citrate (CC) is a nonsteroidal compound and induces ovulation indirectly. The wide usage of the CC raises a question; is it safe or not? In the light of this question, this review aimed to highlight all researches and insights into the association between the use of CC and risk of genotoxicity, cytotoxicity, embryotoxicity, teratogenicity and risk of different cancer types. We conducted a MEDLINE/PubMed, Scopus, Web of Science, Google Scholar search. After a careful screening process of all authors, 32 of these articles were considered as appropriate, and reviewed...
November 20, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29156750/somatic-mutations-in-cdh1-and-ctnnb1-in-primary-carcinomas-at-13-anatomic-sites
#5
Evan L Busch, Jason L Hornick, Renato Umeton, Adem Albayrak, Neal I Lindeman, Laura E MacConaill, Elizabeth P Garcia, Matthew Ducar, Timothy R Rebbeck
Metastases are involved in most cancer deaths. Evidence has suggested that cancer cell detachment from primary tumors might occur largely via the mechanism of epithelial-mesenchymal transition (EMT) activated by epigenetic events, but data addressing other possible triggers of detachment, particularly genetic mutations, have been limited. Using the Profile study of cancer genomics at Dana-Farber Cancer Institute, we examined somatic mutations in the EMT genes CDH1 in 5,106 primary carcinomas and CTNNB1 in 7,578 primary carcinomas across 13 anatomic sites: urinary bladder, breast, colon/rectum, endometrium, esophagus, kidney, lung, ovary, pancreas, prostate, skin (non-melanoma), stomach, and thyroid...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29146391/small-diameter-hysteroscopic-metroplasty-for-a-septate-uterus-after-open-assisted-laparoscopic-radical-trachelectomy
#6
Akimasa Takahashi, Hiroyuki Kanao, Nobuhiro Takeshima
STUDY OBJECTIVE: To describe a two-step fertility preservation technique for early-stage cervical cancer of a patient with a complete septate uterus. DESIGN: A step-by-step demonstration and explanation of the technique in a surgical video (Canadian Task Force Classification III). SETTING: Center for cancer, a tertiary referral center. The patient provided informed consent to use images and videos of the procedure. Institutional Review Board approval was not required for this kind of procedure...
November 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29140883/mage-a4-and-mage-a1-immunohistochemical-expression-in-high-grade-endometrial-cancer
#7
Sanja Srdelić, Ivana Kuzmić-Prusac, Giulio C Spagnoli, Antonio Juretić, Vesna Čapkun
The aim was to investigate MAGE-A4 and MAGE-A1 protein expression in high-grade endometrial cancer and determine its correlation with histologic subtype, FIGO stage, presence of vascular invasion, disease free, and overall survival. Immunohistochemical staining was performed by using 77B (MAGE-A1) and 57B (MAGE-A4) monoclonal antibodies on paraffin-embedded sections from high-grade endometrial cancers diagnosed in University Hospital Split between 1998 and 2011 (n=77). Median follow-up time for survivors was 48 mo...
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29137657/p53-aberrations-in-low-grade-endometrioid-carcinoma-of-the-endometrium-with-nodal-metastases-possible-insights-on-pathogenesis-discerned-from-immunohistochemistry
#8
Oluwole Fadare, Vinita Parkash
BACKGROUND: TP53 mutations are rarely identified in low grade endometrioid carcinoma of the endometrium, and their pathogenic significance in such tumors is evidenced by the fact that TP53 aberrations have been associated with reduced recurrence-free survival in this subset of tumors. However, TP53 aberrations may not always represent a driving molecular event in a given endometrial cancer with a mutation. In this case study, the immunophenotype of a distinctive low grade endometrioid adenocarcinoma with an unusual pattern of lymph node metastases is used to explore the possible roles for underlying TP53-related molecular events in its pathogenesis...
November 14, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/29134301/prostaglandin-e2-receptor-ep1-in-healthy-and-diseased-human-endometrium
#9
Junyan Zhu, Doris Mayr, Christina Kuhn, Sven Mahner, Udo Jeschke, Viktoria von Schönfeldt
Prostaglandin E2 (PGE2) is well described to be associated with both endometrial functions and disorders. The primary aim of this study was to explore the underlying mechanisms that affect the growth and function of endometrial epithelium and stroma by assessing the staining intensity of PGE2 receptors (EP) in healthy endometrium across the menstrual cycle and in pathological endometrium, such as ovarian endometriosis and endometrial cancer. We retrospectively analyzed the EPs staining intensity in human nonpregnant endometrium throughout the menstrual cycle by immunohistochemistry and further focused on EP1 (n = 42)...
November 13, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29133384/estrogen-and-high-fat-diet-induced-alterations-in-c57bl-6-mice-endometrial-transcriptome-profile
#10
Yali Cheng, Qiaoying Lv, Bingying Xie, Bingyi Yang, Weiwei Shan, Chengcheng Ning, Bing Li, Liying Xie, Chao Gu, Xuezhen Luo, Xiaojun Chen, Qin Zhu
Unopposed estrogen stimulation and insulin resistance are known to play important roles in endometrial cancer (EC), but the interaction between these two factors and how they contribute to endometrial lesions are not completely elucidated. To investigate the endometrial transcriptome profile and the associated molecular pathway alterations, we established an ovariectomized C57BL/6 mouse model treated with subcutaneous implantation of 17-β estradiol (E2) pellet and/or high-fat diet (HFD) for 12 weeks to mimic sustained estrogen stimulation and insulin resistance...
November 13, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29132343/diet-and-endometrial-cancer-a-focus-on-the-role-of-fruit-and-vegetable-intake-mediterranean-diet-and-dietary-inflammatory-index-in-the-endometrial-cancer-risk
#11
Fulvio Ricceri, Maria Teresa Giraudo, Francesca Fasanelli, Dario Milanese, Veronica Sciannameo, Laura Fiorini, Carlotta Sacerdote
BACKGROUND: Endometrial cancer is the fourth most common cancer in European women. The major risk factors for endometrial cancer are related to the exposure of endometrium to estrogens not opposed to progestogens, that can lead to a chronic endometrial inflammation. Diet may play a role in cancer risk by modulating chronic inflammation. METHODS: In the framework of a case-control study, we recruited 297 women with newly diagnosed endometrial cancer and 307 controls from Northern Italy...
November 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29123347/referral-patterns-of-gynecological-cancer-patients-to-a-palliative-medicine-unit-a-2-years-retrospective-analysis
#12
Shrikant Atreya
Introduction: Patients with advanced gynecological malignancies often present with a high burden of symptoms endangering their quality of life. Objective: This study aims at assessing the symptom prevalence in patients with gynecological malignancies referred to palliative care and identify factors that predict high symptom burden. Methodology: This was a retrospective data analysis of gynecological cancer patients referred to palliative medicine department...
October 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29113269/the-expression-and-significance-of-histone-lysine-methylation-in-endometrial-cancer
#13
Qing Li, Nan Jia, Xiang Tao, Keqin Hua, Weiwei Feng
Histone modifications of lysine residues have been implicated as having diagnostic and/or prognostic significance in numerous types of cancer. In the present study, the significance of the histone H3 methylation of lysine 4 (H3K4) and lysine 27 (H3K27) were investigated in endometrial cancer. Specifically, immunohistochemical analysis was used to detect the cellular expression levels of H3K27 trimethylation (H3K27me3), H3K4 trimethylation (H3K4me3) and H3K4 dimethylation (H3K4me2) in glandular epithelial tissues and stromal tissues...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29108246/mrp4-regulates-enac-dependent-creb-cox-2-pge2-signaling-during-embryo-implantation
#14
Jun-Jiang Chen, Yan Wang, Xiaojing Meng, Ye Chun Ruan, Fei Zou, Hsiao Chang Chan
Multi-drug resistance protein 4 (MRP4), a potential chemotherapeutic target as well as a transporter for endogenous signaling molecules (e.g. prostaglandins), is known to be expressed in the endometrium, although its possible role(s) in the physiology of the endometrium remains unknown. Here, we show that MRP4 is upregulated at implantation window and localized to the basolateral membrane of the endometrial epithelium, the interface between the epithelium and stroma in mice. In human endometrial epithelial cells, MRP4 expression is upregulated by ENaC activation and the inhibition of MRP4 blocks ENaC-dependent PGE2 release as well as phosphorylation of CREB...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29106744/germ-cell-tumor-growth-patterns-originating-from-clear-cell-carcinomas-of-the-ovary-and-endometrium-a-comparative-immunohistochemical-study-favouring-their-origin-from-somatic-stem-cells
#15
F F Nogales, J Prat, M Schuldt, N Cruz-Viruel, B Kau, E D'Angelo, X Matias-Guiu, A Vidal, W G McCluggage, J W Oosterhuis
AIMS: To report a series of 11 ovarian and one endometrial neoplasm in elderly patients with mixed clear cell tumour and germ cell tumour (GCT) components, to compare their immunohistochemical and demonstrate a putative stem cell population. METHODS AND RESULTS: The clear cell tumours included 11 clear cell carcinomas (CCC) and 1 borderline clear cell tumour, while the GCT always included glandular yolk sac tumour (YST). In 4 cases, there were also foci of teratoma with immature neuroepithelial and endodermal tissues, and undifferentiated areas showing true embryoids...
November 6, 2017: Histopathology
https://www.readbyqxmd.com/read/29096350/endometrioid-adenocarcinoma-originating-simultaneously-from-endometrium-sites-of-adenomyosis-and-ovarian-endometriosis-a-case-report-and-review-of-our-cancer-database
#16
Lena Tashima, Kensuke Hori, Hitomi Ono, Teruaki Nagano, Shin-Ichi Nakatsuka, Kimihiko Ito
INTRODUCTION: Although adenomyosis is a common disease, it is a relatively rare site for cancer origin. On the other hand, chocolate cysts have the potential to develop into cancer. We report a case of endometrioid adenocarcinoma occurred at three sites simultaneously; uterine endometrium, adenomyosis and ovarian endometriosis. PRESENTATION OF CASE: A 51-year-old woman underwent total hysterectomy and bilateral salpingo-oophorectomy after a diagnosis of corpus cancer (endometrioid adenocarcinoma, G1) stage IA...
October 30, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29081412/mir-101-reduces-cell-proliferation-and-invasion-and-enhances-apoptosis-in-endometrial-cancer-via-regulating-pi3k-akt-mtor
#17
Suxia Zhang, Min Wang, Qirong Li, Ping Zhu
PI3K/Akt/mTOR signaling pathway plays an important role in tumor development. mTOR overexpression and PI3K/ Akt/mTOR signaling pathway enhancement were found in endometrial cancer (EC). MiR-101 was found downregulated in EC. Bioinformatics analysis showed the binding site between miR-101 and the 3'-UTR of mTOR mRNA. This study investigated the role of miR-101 in affecting EC proliferation, apoptosis, and invasion, and mediating mTOR expression. EC tumor tissue and normal endometrial tissue were collected from Jinan maternity and child care hospital...
October 13, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29072180/clinicopathologic-and-survival-results-in-serous-endometrium-carcinoma-and-subgroup-analysis-for-mixed-serous-and-pure-serous-histology
#18
Alpaslan Kaban, Samet Topuz, Hamdullah Sözen, Yağmur Minareci, Yavuz Salihoğlu
OBJECTIVE: To review theclinicopathologic and survival outcomes of the patients with serous endometrial cancer (EC) andto investigate subgroup analysis based on pure serous and mixed serous EC subtypes Material and Methods: Patients who had undergone EC surgery between 2002 and 2014 and who were reported as serous EC were enrolled in the study. All patients were diagnosed with serous endometrial cancer or mixed serous endometrial cancer with serous component higher than 10% based on the postoperative pathology report Results: A total of 93 patients were analyzed...
October 26, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29069006/malignant-changes-in-adenomyosis-in-patients-with-endometrial-adenocarcinoma-a-case-series
#19
Xuemei Mao, Wei Zheng, Weibo Mao
The aim of the study is to describe the clinical characteristics and prognosis of malignant transformation of adenomyosis in patients with endometrial cancer.In this retrospective descriptive study, the clinical data of patients with endometrial cancer (n = 127) who were admitted at our hospital between January 2006 and December 2013 were evaluated.Among the 127 patients with endometrial cancer, 24 patients had endometrial cancer concurrently with adenomyosis. Among these 24 patients, 3 were diagnosed with malignant transformation of adenomyosis...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29050779/transcriptome-landscape-of-long-intergenic-non-coding-rnas-in-endometrial-cancer
#20
Bei Jun Chen, Frances L Byrne, Konii Takenaka, Susan C Modesitt, Ellen M Olzomer, James D Mills, Rhonda Farrell, Kyle L Hoehn, Michael Janitz
Endometrial cancer is the most common gynecological malignancy in the developed world. It is the fifth most common cancer and accounts for 4.8% of all cancers in women. Long intergenic non-coding RNAs (lincRNAs), a subclass of long non-coding RNAs, are pervasively transcribed throughout the human genome. OBJECTIVE: LincRNA expression patterns in endometrial cancer compared to normal healthy tissue are poorly characterised. In this study, the lincRNA transcriptome of endometrial cancers and adjacent normal endometrium from the same patients was sequenced and compared with transcriptomes of other gynaecologic malignancies including ovarian and cervical cancers...
October 16, 2017: Gynecologic Oncology
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