keyword
https://read.qxmd.com/read/38478804/csf-%C3%AE-amyloid-and-tau-biomarker-changes-in-veterans-with-mild-traumatic-brain-injury
#21
JOURNAL ARTICLE
Ge Li, Jeffrey Iliff, Jane Shofer, Cynthia L Mayer, James Meabon, David Cook, Kathleen F Pagulayan, Murray A Raskind, Henrik Zetterberg, Kaj Blennow, Elaine R Peskind
BACKGROUND AND OBJECTIVES: Moderate-to-severe traumatic brain injuries (TBI) have been reported to increase the risk of Alzheimer disease (AD). Whether mild TBI (mTBI) in veterans confers a similar increased risk of AD is less known. This study investigated early AD changes using CSF biomarkers in veterans with blast mTBI. METHODS: This was a cross-sectional case-control study of veterans with mTBI and non-mTBI veterans and civilians from 2 study sources. Blast-mTBI veterans had at least 1 war zone blast or combined blast/impact mTBI meeting Veterans Affairs (VA) and Department of Defense (DoD) criteria for mTBI...
April 9, 2024: Neurology
https://read.qxmd.com/read/38476068/bedside-ultrasonographic-evaluation-of-optic-nerve-sheath-diameter-for-monitoring-of-intracranial-pressure-in-traumatic-brain-injury-patients-a-cross-sectional-study-in-level-ii-trauma-care-center-in-india
#22
JOURNAL ARTICLE
Sujit J Kshirsagar, Anandkumar H Pande, Sanyogita V Naik, Alok Yadav, Ruchira M Sakhala, Sangharsh M Salve, Aysath Nuhaimah, Priyanka Desai
BACKGROUND: Optic nerve sheath diameter (ONSD) is an emerging non-invasive, easily accessible, and possibly useful measurement for evaluating changes in intracranial pressure (ICP). The utilization of bedside ultrasonography (USG) to measure ONSD has garnered increased attention due to its portability, real-time capability, and lack of ionizing radiation. The primary aim of the study was to assess whether bedside USG-guided ONSD measurement can reliably predict increased ICP in traumatic brain injury (TBI) patients...
February 2024: Acute and critical care
https://read.qxmd.com/read/38475766/non-stem-cell-derived-exosomes-a-novel-therapeutics-for-neurotrauma
#23
REVIEW
Xinyu Nie, Tianyang Yuan, Tong Yu, Zhihe Yun, Tao Yu, Qinyi Liu
Neurotrauma, encompassing traumatic brain injuries (TBI) and spinal cord injuries (SCI) impacts a significant portion of the global population. While spontaneous recovery post-TBI or SCI is possible, recent advancements in cell-based therapies aim to bolster these natural reparative mechanisms. Emerging research indicates that the beneficial outcomes of such therapies might be largely mediated by exosomes secreted from the administered cells. While stem cells have garnered much attention, exosomes derived from non-stem cells, including neurons, Schwann cells, microglia, and vascular endothelial cells, have shown notable therapeutic potential...
March 12, 2024: Journal of Nanobiotechnology
https://read.qxmd.com/read/38474990/time-series-modeling-and-forecasting-of-cerebral-pressure-flow-physiology-a-scoping-systematic-review-of-the-human-and-animal-literature
#24
REVIEW
Nuray Vakitbilir, Logan Froese, Alwyn Gomez, Amanjyot Singh Sainbhi, Kevin Y Stein, Abrar Islam, Tobias J G Bergmann, Izabella Marquez, Fiorella Amenta, Younis Ibrahim, Frederick A Zeiler
The modeling and forecasting of cerebral pressure-flow dynamics in the time-frequency domain have promising implications for veterinary and human life sciences research, enhancing clinical care by predicting cerebral blood flow (CBF)/perfusion, nutrient delivery, and intracranial pressure (ICP)/compliance behavior in advance. Despite its potential, the literature lacks coherence regarding the optimal model type, structure, data streams, and performance. This systematic scoping review comprehensively examines the current landscape of cerebral physiological time-series modeling and forecasting...
February 23, 2024: Sensors
https://read.qxmd.com/read/38469411/on-propagation-in-networks-promising-models-beyond-network-diffusion-to-describe-degenerative-brain-diseases-and-traumatic-brain-injuries
#25
JOURNAL ARTICLE
Davide Vergni, Paola Stolfi, Annalisa Pascarella
Introduction: Connections among neurons form one of the most amazing and effective network in nature. At higher level, also the functional structures of the brain is organized as a network. It is therefore natural to use modern techniques of network analysis to describe the structures of networks in the brain. Many studies have been conducted in this area, showing that the structure of the neuronal network is complex, with a small-world topology, modularity and the presence of hubs. Other studies have been conducted to investigate the dynamical processes occurring in brain networks, analyzing local and large-scale network dynamics...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38469139/brain-derived-neuerotrophic-factor-and-related-mechanisms-that-mediate-and-influence-progesterone-induced-neuroprotection
#26
REVIEW
Meharvan Singh, Vignesh R Krishnamoorthy, Seongcheol Kim, Saira Khurana, Heather M LaPorte
Historically, progesterone has been studied significantly within the context of reproductive biology. However, there is now an abundance of evidence for its role in regions of the central nervous system (CNS) associated with such non-reproductive functions that include cognition and affect. Here, we describe mechanisms of progesterone action that support its brain-protective effects, and focus particularly on the role of neurotrophins (such as brain-derived neurotrophic factor, BDNF), the receptors that are critical for their regulation, and the role of certain microRNA in influencing the brain-protective effects of progesterone...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38468559/transcranial-doppler-ultrasound-and-concussion-supplemental-symptoms-with-physiology-a-systematic-review
#27
JOURNAL ARTICLE
Matthew Neill, Joel Burma, Lauren N Miutz, Courtney Kennedy, Linden Penner, Kailey Newel, Jonathan Smirl
Sport-related concussion (SRC) can impair the cerebrovasculature both acutely and chronically. Transcranial Doppler (TCD) ultrasound assessment has the potential to illuminate the mechanisms of impairment and provide an objective evaluation of SRC. The current systematic review investigated studies employing TCD ultrasound assessment of intracranial arteries across three broad categories of cerebrovascular regulation: neurovascular coupling (NVC), cerebrovascular reactivity (CVR), and dynamic cerebral autoregulation (dCA)...
March 12, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38468502/characterizing-diffusion-from-microdialysis-catheters-in-the-human-brain-a-magnetic-resonance-imaging-study-with-gadobutrol
#28
JOURNAL ARTICLE
Matthew George Stovell, Pascal P R Ruetten, Daniel J Tozer, Yoann Launey, Chisomo Zimphango, Eric Peter Thelin, Victoria C Lupson, Susan Giorgi-Coll, Thomas Adrian Carpenter, Marius O Mada, Ibrahim Jalloh, Adel Helmy, Mark H Wilson, Martin J Graves, David Menon, Keri L H Carpenter, Peter John Hutchinson
Cerebral microdialysis (CMD) catheters allow continuous monitoring of patients' cerebral metabolism in severe traumatic brain injury (TBI). The catheters consist of a terminal semi-permeable membrane that is inserted into the brain's interstitium to allow perfusion fluid to equalize with the surrounding cerebral extracellular environment before being recovered through a central non-porous channel. However, it is unclear how far recovered fluid and suspended metabolites have diffused from within the brain, and therefore what volume or region of brain tissue the analyses of metabolism represent...
March 12, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38464893/the-neurological-wake-up-test-in-severe-pediatric-traumatic-brain-injury-a-long-term-single-center-experience
#29
JOURNAL ARTICLE
Hilde D Mulder, Jelte Helfferich, Martin C J Kneyber
OBJECTIVES: To describe the use and outcomes of the neurological wake-up test (NWT) in pediatric severe traumatic brain injury (pTBI). DESIGN: Retrospective single-center observational cohort study. SETTING: Medical-surgical tertiary pediatric intensive care unit (PICU) in a university medical center and Level 1 Trauma Center. PATIENTS: Children younger than 18 years with severe TBI [i.e., Glasgow Coma Scale (GCS) of ≤8] admitted between January 2010 and December 2020...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38463419/investigating-the-association-between-extended-participation-in-collision-sports-and-fluid-biomarkers-among-masters-athletes
#30
JOURNAL ARTICLE
Lauren P Giesler, William T O'Brien, Georgia F Symons, Sabrina Salberg, Gershon Spitz, Robb Wesselingh, Terence J O'Brien, Richelle Mychasiuk, Sandy R Shultz, Stuart J McDonald
Traumatic brain injuries (TBIs) and concussions are prevalent in collision sports, and there is evidence that levels of exposure to such sports may increase the risk of neurological abnormalities. Elevated levels of fluid-based biomarkers have been observed after concussions or among athletes with a history of participating in collision sports, and certain biomarkers exhibit sensitivity toward neurodegeneration. This study investigated a cohort of 28 male amateur athletes competing in "Masters" competitions for persons >35 years of age...
2024: Neurotrauma reports
https://read.qxmd.com/read/38463415/life-after-traumatic-brain-injury-effects-on-the-lifestyle-and-quality-of-life-of-community-dwelling-patients
#31
JOURNAL ARTICLE
Yi-Chia Wei, Chih-Ken Chen, Chemin Lin, Yu-Chiau Shyu, Pin-Yuan Chen
Persons who have experienced traumatic brain injury (TBI) may encounter a range of changes in their physical, mental, and cognitive functions as well as high fatigue levels. To gain a comprehensive understanding of the challenges faced by persons after TBI, we conducted multi-domain assessments among community-dwelling persons with a history of TBI and compared them with age- and sex-matched controls from the Northeastern Taiwan Community Medicine Research Cohort between 2019 and 2021. A total of 168 persons with TBI and 672 non-TBI controls were not different in terms of demographics, comorbidities, and physiological features...
2024: Neurotrauma reports
https://read.qxmd.com/read/38462573/ventriculostomy-associated-infection-vai-in-patients-with-acute-brain-injury-a-retrospective-study
#32
JOURNAL ARTICLE
Pernille Nielsen, Markus Harboe Olsen, Rasmus Stanley Willer-Hansen, John Hauerberg, Helle Krogh Johansen, Aase Bengaard Andersen, Jenny Dahl Knudsen, Kirsten Møller
BACKGROUND: Ventriculostomy-associated infection (VAI) is common after external ventricular drains (EVD) insertion but is difficult to diagnose in patients with acute brain injury. Previously, we proposed a set of criteria for ruling out VAI in traumatic brain injury. This study aimed to validate these criteria. For exploratory purposes, we sought to develop and validate a score for VAI risk assessment in patients with different types of severe acute brain injury. METHODS: This retrospective cohort study included adults with acute brain injury who received an EVD and in whom CSF samples were taken over a period of 57 months...
March 11, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38458896/risk-factors-and-predictive-model-of-cerebral-edema-after-road-traffic-accidents-related-traumatic-brain-injury
#33
JOURNAL ARTICLE
Di-You Chen, Peng-Fei Wu, Xi-Yan Zhu, Wen-Bing Zhao, Shi-Feng Shao, Jing-Ru Xie, Dan-Feng Yuan, Liang Zhang, Kui Li, Shu-Nan Wang, Hui Zhao
PURPOSE: Cerebral edema (CE) is the main secondary injury following traumatic brain injury (TBI) caused by road traffic accidents (RTAs). It is challenging to be predicted timely. In this study, we aimed to develop a prediction model for CE by identifying its risk factors and comparing the timing of edema occurrence in TBI patients with varying levels of injuries. METHODS: This case control study included 218 patients with TBI caused by RTAs. The cohort was divided into CE and non-CE groups, according to CT results within 7 days...
February 23, 2024: Chinese Journal of Traumatology
https://read.qxmd.com/read/38458253/assessing-patients-perception-analyzing-the-quality-reliability-comprehensibility-and-the-mentioned-medical-concepts-of-traumatic-brain-injury-videos-on-youtube
#34
JOURNAL ARTICLE
Mustafa Hüseyin Temel, Yakup Erden, Fatih Bağcıer
AIM: The aim of this study is to analyze the quality, reliability, comprehensibility, and the mentioned medical concepts of traumatic brain injury (TBI) related videos on YouTube. MATERIAL - METHODS: "Traumatic brain injury" and related Google Trends queries were used and 328 videos included. Categorization, quality assessment via a 5-point Global Quality Scale, reliability evaluation using a modified DISCERN scale, comprehensibility assessment using Flesch-Kincaid Reading Ease and Flesch-Kincaid Grade Level, and consensus-based classification for usefulness were performed...
March 6, 2024: World Neurosurgery
https://read.qxmd.com/read/38455629/plasma-interleukin-6-as-an-outcome-predictor-of-traumatic-brain-injury-patients
#35
JOURNAL ARTICLE
Khairunnisa Ichwan, Syahrul Gazali, Suherman Suherman, Desiana Desiana, Nurjannah Nurjannah
Traumatic brain injury is one of the leading causes of death and disability in young adults. Previous studies have suggested that neuroinflammatory process involves the overexpression of interleukin 6 (IL-6); however, data on the predictive ability of IL-6 is limited and conflicting in traumatic head injury patients. The aim of this study was to assess the ability of plasma IL-6 as a predictor of outcome in head injury patients. A cross-sectional study was conducted between June and December 2020 among traumatic head injury patients admitted to Dr...
December 2023: Narra J
https://read.qxmd.com/read/38453632/symptoms-associated-with-exercise-intolerance-and-resting-heart-rate-following-mild-traumatic-brain-injury
#36
JOURNAL ARTICLE
Jacinta Thorne, Sarah C Hellewell, Gill Cowen, Alexander Ring, Amanda Jefferson, HuiJun Chih, Aleksandra K Gozt, Francesca Buhagiar, Elizabeth Thomas, Melissa Papini, Michael Bynevelt, Antonio Celenza, Dan Xu, Stephen Honeybul, Carmela F Pestell, Daniel Fatovich, Melinda Fitzgerald
OBJECTIVES: People may experience a myriad of symptoms after mild traumatic brain injury (mTBI), but the relationship between symptoms and objective assessments is poorly characterized. This study sought to investigate the association between symptoms, resting heart rate (HR), and exercise tolerance in individuals following mTBI, with a secondary aim to examine the relationship between symptom-based clinical profiles and recovery. METHODS: Prospective observational study of adults aged 18 to 65 years who had sustained mTBI within the previous 7 days...
February 27, 2024: Journal of Head Trauma Rehabilitation
https://read.qxmd.com/read/38452968/peculiarities-of-ion-homeostasis-in-neurons-containing-calcium-permeable-ampa-receptors
#37
JOURNAL ARTICLE
Sergei A Maiorov, Bakhytzhan K Kairat, Alexey V Berezhnov, Valery P Zinchenko, Sergei G Gaidin, Artem M Kosenkov
Glutamate excitotoxicity accompanies numerous brain pathologies, including traumatic brain injury, ischemic stroke, and epilepsy. Disturbances of the ion homeostasis, mitochondria dysfunction, and further cell death are considered the main detrimental consequences of excitotoxicity. It is well known that neurons demonstrate different vulnerability to pathological exposures. In this regard, neurons containing calcium-permeable AMPA receptors (CP-AMPARs) may show higher susceptibility to excitotoxicity due to an additional pathway of Ca2+ influx...
March 5, 2024: Archives of Biochemistry and Biophysics
https://read.qxmd.com/read/38450266/oxygen-saturation-profile-in-traumatic-brain-injury-animal-model-after-propofol-administration
#38
JOURNAL ARTICLE
Kulsum Kulsum, Syahrul Syahrul, Kartini Hasbalah, Ummu Balqis, Taufik Suryadi
Traumatic brain injury (TBI) is a traumatic that often leads to death due to untreatable cerebral hypoxia, indicated by oxygen saturation of <90%. Cerebral hypoxia is rarely monitored and thereby often overlooked as a cause of mortality and monitoring oxygen saturation is an accurate method to detect the condition. Propofol, an anesthetic agent, is commonly used in the management of TBI; however, its effect on brain tissue and cerebral hypoxia in TBI cases is not well understood. The aim of this study was to evaluate the profile of oxygen saturation in TBI animal model after propofol administration...
August 2023: Narra J
https://read.qxmd.com/read/38448704/the-relationship-between-blast-related-mild-traumatic-brain-injury-and-executive-function-is-moderated-by-white-matter-integrity
#39
JOURNAL ARTICLE
Molly C O'Brien, Seth G Disner, Nicholas D Davenport, Scott R Sponheim
Blast-related mild traumatic brain injury (BR mTBI) is a critical research area in recent combat veterans due to increased prevalence of survived blasts. Post-BR mTBI outcomes are highly heterogeneous and defining neurological differences may help in discrimination and prediction of cognitive outcomes. This study investigates whether white matter integrity, measured with diffusion tensor imaging (DTI), could influence how remote BR mTBI history is associated with executive control. The sample included 151 Veterans from the Minneapolis Veterans Affairs Medical Center who were administered a clinical/TBI assessment, neuropsychological battery, and DTI scan as part of a larger battery...
March 6, 2024: Brain Imaging and Behavior
https://read.qxmd.com/read/38445975/evaluation-of-chatgpt-in-predicting-6-month-outcomes-after-traumatic-brain-injury
#40
JOURNAL ARTICLE
Clement Gakuba, Charlene Le Barbey, Alexandre Sar, Gregory Bonnet, Damiano Cerasuolo, Mikhael Giabicani, Jean-Denis Moyer
OBJECTIVES: To evaluate the capacity of ChatGPT, a widely accessible and uniquely popular artificial intelligence-based chatbot, in predicting the 6-month outcome following moderate-to-severe traumatic brain injury (TBI). DESIGN: Single-center observational retrospective study. SETTING: Data are from a neuro-ICU from a level 1 trauma center. PATIENTS: All TBI patients admitted to ICU between September 2021 and October 2022 were included in a prospective database...
March 6, 2024: Critical Care Medicine
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