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https://www.readbyqxmd.com/read/29345192/cross-validation-of-the-dot-counting-test-in-a-large-sample-of-credible-and-non-credible-patients-referred-for-neuropsychological-testing
#1
Courtney McCaul, Kyle B Boone, Annette Ermshar, Maria Cottingham, Tara L Victor, Elizabeth Ziegler, Michelle A Zeller, Matthew Wright
OBJECTIVE: To cross-validate the Dot Counting Test in a large neuropsychological sample. METHOD: Dot Counting Test scores were compared in credible (n = 142) and non-credible (n = 335) neuropsychology referrals. RESULTS: Non-credible patients scored significantly higher than credible patients on all Dot Counting Test scores. While the original E-score cut-off of ≥17 achieved excellent specificity (96.5%), it was associated with mediocre sensitivity (52...
January 18, 2018: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29343203/cognition-health-related-quality-of-life-and-depression-ten-years-after-moderate-to-severe-traumatic-brain-injury-a-prospective-cohort-study
#2
Erik Grauwmeijer, Majanka Heijenbrok-Kal, Lianne Peppel, Chantal Hartjes, Iain Haitsma, Inge de Koning, Gerard Ribbers
The aim of this study was to evaluate cognitive function ten years after moderate-severe TBI and to investigate the associations between cognitive function, depression and Health-Related Quality of Life (HRQoL). In this prospective cohort study, with measurements at 3, 6, 12, 18, 24, 36, and 120 months post-TBI, patients aged 18-67 years (N=113) with moderate-severe TBI were recruited. Main outcome measures were depression (CES-D), subjective cognitive functioning (CFQ), objective cognitive functioning, and HRQoL (SF-36)...
January 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29341793/platelet-transfusion-does-not-improve-outcomes-in-patients-with-brain-injury-on-antiplatelet-therapy
#3
Jeremy L Holzmacher, Cassandra Reynolds, Mayur Patel, Patrick Maluso, Seth Holland, Nathaniel Gamsky, Henry Moore, Elizabeth Acquista, Matthew Carrick, Richard Amdur, Heather Hancock, Michael Metzler, Julie Dunn, Babak Sarani
INTRODUCTION: Platelet dysfunction following traumatic brain injury (TBI) is associated with worse outcomes. The efficacy of platelet transfusion to reverse antiplatelet medication (APM) remains unknown. Thrombelastography platelet mapping (TEG-PM) assesses platelet function. We hypothesize that platelet transfusion can reverse the effects of APM but does not improve outcomes following TBI. METHODS: An observational study at six US trauma centres was performed. Adult patients on APM with CT evident TBI after blunt injury were enrolled...
January 17, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29338452/an-update-on-diagnostic-and-prognostic-biomarkers-for-traumatic-brain-injury
#4
Kevin K Wang, Zhihui Yang, Tian Zhu, Yuan Shi, Richard Rubenstein, J Adrian Tyndall, Geoff T Manley
Traumatic brain injury (TBI) is a major worldwide neurological disorder of epidemic proportions. To date, there are still no FDA-approved therapies to treat any forms of TBI. Encouragingly, there are emerging data showing that biofluid-based TBI biomarker tests have the potential to diagnose the presence of TBI of different severities including concussion, and to predict outcome. Area covered: The authors provide an update on the current knowledge of TBI biomarkers, including protein biomarkers for neuronal cell body injury (UCH-L1, NSE), astroglial injury (GFAP, S100B), neuronal cell death (αII-spectrin breakdown products), axonal injury (NF proteins), white matter injury (MBP), post-injury neurodegeneration (total Tau and phospho-Tau), post-injury autoimmune response (brain antigen-targeting autoantibodies), and other emerging non-protein biomarkers...
January 17, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29337920/acute-traumatic-endotheliopathy-in-isolated-severe-brain-injury-and-its-impact-on-clinical-outcome
#5
Venencia Albert, Arulselvi Subramanian, Deepak Agrawal, Hara Prasad Pati, Siddhartha Datta Gupta, Asok Kumar Mukhopadhyay
STUDY DESIGN: Prospective observational cohort. OBJECTIVE: To investigate the difference in plasma levels of syndecan-1 (due to glycocalyx degradation) and soluble thrombomodulin (due to endothelial damage) in isolated severe traumatic brain injury (TBI) patients with/without early coagulopathy. A secondary objective was to compare the effects of the degree of TBI endotheliopathy on hospital mortality among patients with TBI-associated coagulopathy (TBI-AC). METHODS: Data was prospectively collected on isolated severe TBI (sTBI) patients with Glasgow Coma Scale (GCS) ≤8 less than 12 h after injury admitted to a level I trauma centre...
January 16, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29334996/italian-guidelines-on-the-assessment-and-management-of-pediatric-head-injury-in-the-emergency-department
#6
REVIEW
Liviana Da Dalt, Niccolo' Parri, Angela Amigoni, Agostino Nocerino, Francesca Selmin, Renzo Manara, Paola Perretta, Maria Paola Vardeu, Silvia Bressan
OBJECTIVE: We aim to formulate evidence-based recommendations to assist physicians decision-making in the assessment and management of children younger than 16 years presenting to the emergency department (ED) following a blunt head trauma with no suspicion of non-accidental injury. METHODS: These guidelines were commissioned by the Italian Society of Pediatric Emergency Medicine and include a systematic review and analysis of the literature published since 2005...
January 15, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29332084/thalamic-deep-brain-stimulation
#7
Benjamin B Whiting, Alexander C Whiting, Donald M Whiting
The use of deep brain stimulation (DBS) of the thalamus has been proven to be a safe and efficacious treatment for the management of many diseases. The most common indication for thalamic DBS remains essential tremor (ET), one of the most common movement disorders in the world. ET patients should be considered for surgical intervention when their tremor has demonstrated to be refractory to medication, a characteristic estimated to be present in roughly 50% of ET cases. Advantages of DBS over thalamotomy include its reversibility, the ability to adjust stimulation settings to optimize efficacy and minimize side effects, the ability to perform bilateral procedures safely, and an association with a lower risk of postoperative cognitive problems...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29329548/the-cost-of-a-pediatric-neurocritical-care-program-for-traumatic-brain-injury-a-retrospective-cohort-study
#8
Steven W Howard, Zidong Zhang, Paula Buchanan, Stephanie L Bernell, Christine Williams, Lindsey Pearson, Michael Huetsch, Jeff Gill, Jose A Pineda
BACKGROUND: Inpatient care for children with severe traumatic brain injury (sTBI) is expensive, with inpatient charges averaging over $70,000 per case (Hospital Inpatient, Children Only, National Statistics. Diagnoses- clinical classification software (CCS) principal diagnosis category 85 coma, stupor, and brain damage, and 233 intracranial injury. Diagnoses by Aggregate charges [ https://hcupnet.ahrq.gov/#setup ]). This ranks sTBI in the top quartile of pediatric conditions with the greatest inpatient costs (Hospital Inpatient, Children Only, National Statistics...
January 12, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29328681/seizures-among-active-component-service-members-u-s-armed-forces-2007-2016
#9
Julie A Bytnar, Shauna Stahlman, Saixia Ying
Traumatic brain injury (TBI) is a known risk factor for seizures. Evidence also shows that post-traumatic stress disorder (PTSD) is associated with seizures, but the relationship in the absence of TBI remains unclear. This retrospective study spanning 2007-2016 separately quantifies the rates of seizures diagnosed among deployed and non-deployed active component military service members to understand the factors associated with seizures and whether they differ in deployed settings. Higher rates of seizures were associated with service members who were in the Army or Marine Corps; female; black; younger; lower enlisted; in a combat-specific, armor/motor transport, or healthcare occupation; and who had no more than one previous deployment...
December 2017: MSMR
https://www.readbyqxmd.com/read/29325484/risk-of-erectile-dysfunction-after-traumatic-brain-injury-a-nationwide-population-based-cohort-study-in-taiwan
#10
Yun-Ju Yang, Wu-Chien Chien, Chi-Hsiang Chung, Kun-Ting Hong, Yi-Lin Yu, Dueng-Yuan Hueng, Yuan-Hao Chen, Hsin-I Ma, Hsin-An Chang, Yu-Chen Kao, Hui-Wen Yeh, Nian-Sheng Tzeng
INTRODUCTION: In our study, we aimed to investigate the association between a traumatic brain injury (TBI) and subsequent erectile dysfunction (ED). This is a population-based study using the claims dataset from The National Health Insurance Research Database. METHODS: We included 72,642 patients with TBI aged over 20 years, retrospectively, selected from the longitudinal health insurance database during 2000-2010, according to the ICD-9-CM. The control group consisted of 217,872 patients without TBI that were randomly chosen from the database at a ratio of 1:3, with age- and index year matched...
January 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29316843/diagnosis-threat-and-underperformance-the-threat-must-be-relevant-and-implicit
#11
Megan Fresson, Benoit Dardenne, Thierry Meulemans
INTRODUCTION: The diagnosis threat (DT) phenomenon shows that, in some cases, reminding people with mild traumatic brain injury (mTBI) about their past neurological history diminishes subsequent cognitive performance. The aim of the present study was to investigate the role of personal relevance (i.e., domain identification) and type of threat (i.e., implicit vs. explicit) as moderating variables. We investigated intrusive thoughts as a potential mediator. METHOD: Control (non-mTBI) and mTBI participants were recruited and completed a domain identification questionnaire...
January 10, 2018: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/29315422/dietary-therapy-restores-glutamatergic-input-to-orexin-hypocretin-neurons-after-traumatic-brain-injury-in-mice
#12
Jonathan E Elliott, Samuel E De Luche, Madeline J Churchill, Cindy Moore, Akiva S Cohen, Charles K Meshul, Miranda M Lim
Study Objectives: In previous work, dietary branched chain amino acid (BCAA) supplementation, precursors to de novo glutamate and gamma-aminobutyric acid (GABA) synthesis, restored impaired sleep-wake regulation and orexin neuronal activity post-traumatic brain injury (TBI) in mice. TBI was speculated to reduce orexin neuronal activity through decreased regional excitatory (glutamate) and/or increased inhibitory (GABA) input. Therefore, we hypothesized TBI would decrease synaptic glutamate and/or increase synaptic GABA in nerve terminals contacting orexin neurons, and BCAA supplementation would restore TBI-induced changes in synaptic glutamate and/or GABA...
January 5, 2018: Sleep
https://www.readbyqxmd.com/read/29311754/correlation-between-cerebral-hemodynamic-and-perfusion-pressure-changes-in-non-human-primates
#13
A Ruesch, M A Smith, G Wollstein, I A Sigal, S Nelson, J M Kainerstorfer
The mechanism that maintains a stable blood flow in the brain despite changes in cerebral perfusion pressure (CPP), and therefore guaranties a constant supply of oxygen and nutrients to the neurons, is known as cerebral autoregulation (CA). In a certain range of CPP, blood flow is mediated by a vasomotor adjustment in vascular resistance through dilation of blood vessels. CA is known to be impaired in diseases like traumatic brain injury, Parkinson's disease, stroke, hydrocephalus and others. If CA is impaired, blood flow and pressure changes are coupled and the oxygen supply might be unstable...
February 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29306988/acute-phase-response-after-fatal-traumatic-brain-injury
#14
Benjamin Ondruschka, Sandra Schuch, Dirk Pohlers, Heike Franke, Jan Dreßler
An inflammatory response occurring after fatal traumatic brain injury (TBI) initiates time-dependent cascades of acute phase response. This may offer the potential to monitor postmortem biomarker levels of several pro-inflammatory cytokines to gain information about the cause of death and the trauma survival time. Cerebrospinal fluid (CSF) and serum samples were collected from forensic autopsies of 95 adult cadavers after postmortem intervals up to 6 days. The cases were divided according to their cause of death into fatal TBI (n = 46) with different survival times and age- and gender-matching non-TBI fatalities as controls (n = 49)...
January 6, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29305336/circulating-osteogentic-precursor-cells-in-non-hereditary-heterotopic-ossification
#15
REVIEW
Kevin P Egan, Gustavo Duque, Mary Ann Keenan, Robert J Pignolo
Non-hereditary heterotopic ossification (NHHO) may occur after musculoskeletal trauma, central nervous system (CNS) injury, or surgery. We previously described circulating osteogenic precursor (COP) cells as a bone marrow-derived type 1 collagen+CD45+subpopulation of mononuclear adherent cells that are able of producing extraskeletal ossification in a murine in vivo implantation assay. In the current study, we performed a tissue analysis of COP cells in NHHO secondary to defined conditions, including traumatic brain injury, spinal cord injury, cerebrovascular accident, trauma without neurologic injury, and joint arthroplasty...
January 2, 2018: Bone
https://www.readbyqxmd.com/read/29286534/fitness-training-for-cardiorespiratory-conditioning-after-traumatic-brain-injury
#16
REVIEW
Leanne Hassett, Anne M Moseley, Alison R Harmer
BACKGROUND: Reduced cardiorespiratory fitness (cardiorespiratory deconditioning) is a common consequence of traumatic brain injury (TBI). Fitness training may be implemented to address this impairment. OBJECTIVES: The primary objective of this updated review was to evaluate whether fitness training improves cardiorespiratory fitness in people who have sustained a TBI. The secondary objectives were to evaluate whether fitness training improves body function and structure (physical and cognitive impairments, psychological responses resulting from the injury), activity limitations and participation restrictions in people who have sustained a TBI as well as to evaluate its safety, acceptance, feasibility and suitability...
December 29, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29283307/using-the-california-verbal-learning-test-second-edition-as-an-embedded-performance-validity-measure-among-individuals-with-tbi-and-individuals-with-psychiatric-disorders
#17
Virginia C Persinger, Douglas M Whiteside, Lyuba Bobova, Seema D Saigal, Marla J Vannucci, Michael R Basso
OBJECTIVE: Among embedded performance validity tests (PVTs), little research addresses the use of Total Hits and Total False Positives from the California Verbal Learning Test, Second Edition (CVLT-II) in spite of low sensitivity, particularly in psychiatric samples. METHOD: This study examined the classification accuracy of these two measures in individuals with psychiatric disorders or mild traumatic brain injury (MTBI). These samples were separated into two groups using the criteria of passing all PVTs versus failing 2 or more PVTs...
December 28, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29281046/cross-cultural-adaptation-and-psychometric-properties-of-the-audit-and-cage-questionnaires-in-tanzanian-swahili-for-a-traumatic-brain-injury-population
#18
Joao Ricardo Nickenig Vissoci, Julian Hertz, Deena El-Gabri, José Roberto Andrade Do Nascimento, Leonardo Pestillo De Oliveira, Blandina Theophil Mmbaga, Mark Mvungi, Catherine A Staton
Aims: To develop Swahili versions of the Alcohol Use Disorders Identification Test (AUDIT) and CAGE questionnaires and evaluate their psychometric properties in a traumatic brain injury (TBI) population in Tanzania. Methods: Swahili versions of the AUDIT and CAGE were developed through translation and back-translation by a panel of native speakers of both English and Swahili. The translated instruments were administered to a sample of Tanzanian adults from a TBI registry...
January 1, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29277588/sport-related-traumatic-brain-injury-with-and-without-helmets-in-children
#19
Angela Bandte, Friederike-Sophie Fritzsche, Pedram Emami, Getrud Kammler, Klaus Püschel, Kara Krajewski
BACKGROUND: Soccer, bicycling and horseback riding are sports most commonly associated with traumatic brain injury (TBI) in Germany. The latter are commonly practiced with helmets and data on helmet use and usefulness vary widely. METHODS: After ethics approval, retrospective analysis was performed for patients ages 5-17 from 01/2009- 08/2014 based on the diagnosis TBI using the electronic patient file for both university hospital locations. Descriptive data analysis, multi- and univariate logistic regression were employed to calculate the odds ratio...
December 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29259144/antidepressants-for-depression-associated-with-traumatic-brain-injury-a-meta-analytical-study-of-randomised-controlled-trials
#20
A Paraschakis, A H Katsanos
INTRODUCTION: Depression following traumatic brain injury is experienced by 16% to 60% of affected patients. The present study aimed to update the best evidence-based pharmacological treatments for tackling such chronic and debilitating disorders. METHODS: We systematically reviewed and meta-analysed randomised controlled trials published from 1990 until August 2017 that compared the efficacy of antidepressants with placebo in the treatment of post-traumatic brain injury depression...
December 2017: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
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