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https://www.readbyqxmd.com/read/29782989/nadph-oxidase-2-deletion-enhances-neurogenesis-following-traumatic-brain-injury
#1
Jing Wang, Merry W Ma, Krishnan M Dhandapani, Darrell W Brann
The NADPH oxidase (NOX) enzyme family is a major source of reactive oxygen species (ROS) and contributor to the secondary pathology underlying traumatic brain injury (TBI). However, little is known about how NOX-derived ROS influences the proliferation and cell-fate determination of neural stem/progenitor cells (NSCs/NPCs) following TBI. In the current study, we found that deletion of NOX2 (NOX2-KO) significantly decreases the population of radial glia-like NSCs and neuroblasts but maintains the population of non-radial Sox2 expressing stem cells under physiological (non-injury) conditions...
May 18, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29774825/dietary-zinc-modulates-matrix-metalloproteinases-in-traumatic-brain-injury
#2
Angus Scrimgeour, Christopher Carrigan, Michelle Lynn Condlin, Maria L Urso, Roland M van den Berg, Herman P M van Helden, Scott J Montain, Marloes J A Joosen
Animal models of mild traumatic brain injury (mTBI) provide opportunity to examine the extent to which dietary interventions can be used to improve recovery after injury. Animal studies also suggest that matrix metalloproteinases (MMPs) play a role in tissue remodeling post-TBI. Because dietary zinc (Zn) improved recovery in non-blast mTBI models, and the MMPs are Zn-requiring enzymes, we evaluated the effects of low- and adequate Zn diets on MMP expression and behavioral responses, following exposure to a single blast...
May 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29769541/modchimera-a-novel-murine-closed-head-model-of-moderate-traumatic-brain-injury
#3
A D Sauerbeck, C Fanizzi, J H Kim, M Gangolli, P V Bayly, C L Wellington, D L Brody, T T Kummer
Traumatic brain injury is a major source of global disability and mortality. Preclinical TBI models are a crucial component of therapeutic investigation. We report a tunable, monitored model of murine non-surgical, diffuse closed-head injury-modCHIMERA-characterized by impact as well as linear and rotational acceleration. modCHIMERA is based on the Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA) platform. We tested this model at 2 energy levels: 1.7 and 2.1 Joules-substantially higher than previously reported for this system...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768537/the-protection-effect-and-mechanism-of-hyperbaric-oxygen-therapy-in-rat-brain-with-traumatic-injury
#4
Pengcheng Xing, Ke Ma, Lijuan Li, Donglian Wang, Guoyong Hu, Wei Long
PURPOSE: To investigate the effect of hyperbaric oxygen therapy (HBOT) on traumatic brain injury (TBI) outcome. METHODS: The modified Marmarou's weight drop device was used to generate non-lethal moderate TBI rat model, and further developed in vitro astrocytes culturing system. Then, we analyzed the expression changes of interested genes and protein by quantitative PCR and western blot. RESULTS: Multiple HBO treatments significantly reduced the expression of apoptosis promoting genes, such as c-fos, c-jun, Bax and weakened the activation of Caspase-3 in model rats...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29766124/routine-repeat-head-ct-may-not-be-necessary-for-patients-with-mild-tbi
#5
Claire B Rosen, Diego D Luy, Molly R Deane, Thomas M Scalea, Deborah M Stein
Background: Routine repeat cranial CT (RHCT) is standard of care for CT-verified traumatic brain injury (TBI). Despite mixed evidence, those with mild TBI are subject to radiation and expense from serial CT scans. Thus, we investigated the necessity and utility of RHCT for patients with mild TBI. We hypothesized that repeat head CT in these patients would not alter patient care or outcomes. Methods: We retrospectively studied patients suffering from mild TBI (Glasgow Coma Scale (GCS) score 13-15) and treated at the R Adams Cowley Shock Trauma Center from November 2014 through January 2015...
2018: Trauma surgery & acute care open
https://www.readbyqxmd.com/read/29763809/the-impact-of-methamphetamines-in-patients-with-traumatic-brain-injury-a-retrospective-review
#6
Jason Duong, Christopher Elia, Ariel Takayanagi, Taylor Lanzilotta, Ajay Ananda, Dan Miulli
OBJECTIVE: Both neurotoxic and neuroprotective effects of methamphetamines (METH) are being studied. There are few studies evaluating the effects of METH on patients with traumatic brain injury (TBI). The objective of this study is to compare clinical outcomes after TBI in METH users versus non-METH users. PATIENT AND METHODS: A retrospective review of 304 patients with severe traumatic head injury were performed. Patients were evaluated and stratified based on toxicology screening for methamphetamines (METH) or none...
April 27, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29756525/the-effectiveness-of-physical-exercise-as-an-intervention-to-reduce-depressive-symptoms-following-traumatic-brain-injury-a-meta-analysis-and-systematic-review
#7
Sophie A Perry, Rudi Coetzer, Christopher W N Saville
Alongside the obvious health benefits, physical exercise has been shown to have a modest anti-depressant effect for people in the general population. To the authors' knowledge, there are no current literature reviews or meta-analyses available exploring this effect for people with a traumatic brain injury (TBI). A systematic review of intervention studies utilising physical exercise and mood outcome measures for a TBI population was performed in November 2016. Baseline and outcome data were extracted for the nine studies which met the inclusion criteria...
May 13, 2018: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29752909/systematic-review-of-caregiver-and-dyad-interventions-following-adult-traumatic-brain-injury
#8
REVIEW
Natalie Kreitzer, Brad G Kurowski, Tamilyn Bakas
OBJECTIVE: To describe and synthesize the existing literature of published adult TBI family caregiver and dyad intervention studies. Traumatic brain injuries (TBIs) are common and have a significant long-term impact, with some characterizing TBI as a chronic condition. Informal family caregivers of adults with TBI suffer from high rates of burnout, depression, fatigue, anxiety, lower subjective well-being, and poorer levels of physical health compared to non-caregivers. There is a critical gap in the understanding of interventions designed to address the impact of TBI on adult patients and their family caregivers...
May 9, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29751189/risk-factors-predicting-posttraumatic-hydrocephalus-after-decompressive-craniectomy-in-traumatic-brain-injury
#9
Guangfu Di, Qianxin Hu, Dongming Liu, Xiaochun Jiang, Jiu Chen, Hongyi Liu
OBJECTIVE: To identify the risk factors for predicting posttraumatic hydrocephalus (PTH) development after traumatic brain injury (TBI) in patients who underwent decompressive craniectomy (DC). METHODS: This retrospective study included 121 patients who underwent DC after TBI between January 2013 and December 2016 at Yijishan Hospital by 6 different neurosurgeons and were still alive at 6-month follow-up. They were divided into PTH group and non-PTH group according to the presence of PTH...
May 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29748207/use-of-diffusional-kurtosis-imaging-and-dynamic-contrast-enhanced-mr-imaging-to-predict-posttraumatic-epilepsy-in-rabbits
#10
W Li, X Wang, X Wei, M Wang
BACKGROUND AND PURPOSE: Finding a reliable biomarker to thoroughly assess the brain structure changes in posttraumatic epilepsy is of great importance. Our aim was to explore the value of diffusional kurtosis imaging combined with dynamic contrast-enhanced MR imaging in the evaluation of posttraumatic epilepsy. MATERIALS AND METHODS: A modified weight-drop device was used to induce traumatic brain injury. Rabbits were exposed to traumatic brain injury or sham injury...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29744222/chest-wall-stabilization-in-trauma-patients-why-when-and-how
#11
REVIEW
Jose Ribas Milanez de Campos, Thomas W White
Blunt trauma to the chest wall and rib fractures are remarkably frequent and are the basis of considerable morbidity and possible mortality. Surgical remedies for highly displaced rib fractures, especially in cases of flail chest, have been undertaken intermittently for more than 50 years. Rib-specific plating systems have started to be used in the last 10 years. These have ushered in the modern era of rib repair with chest wall stabilization (CWS) techniques that are safer, easier to perform, and more efficient...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29744119/levetiracetam-induced-transaminitis-in-a-young-male-with-traumatic-brain-injury
#12
Vivekananda Rachamallu, Michael M Song, Jace M Reed, Manish Aligeti
Levetiracetam is a commonly prescribed antiepileptic drug for seizure prophylaxis in patients with traumatic brain injury (TBI). Levetiracetam metabolism has been reported to be non-dependent on hepatic cytochrome P450 (CYP450) isoenzyme system. Furthermore, levetiracetam and its metabolites are reported to be eliminated from systemic circulation via renal excretion. Therefore, due to its well-known renal clearance mechanism with no dosage adjustments recommended for hepatic impairment, levetiracetam is often chosen as the drug of choice in patients with suspected or ongoing hepatic dysfunction...
November 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29737870/the-effect-of-donepezil-on-the-cognitive-ability-early-in-the-course-of-recovery-from-traumatic-brain-injury
#13
Kelsey A Campbell, Richard E Kennedy, Robert C Brunner, Sean D Hollis, Ross A Lumsden, Thomas A Novack
OBJECTIVE: To investigate the effect of donepezil on cognitive ability in patients who have sustained a traumatic brain injury (TBI). We hypothesized that donepezil, an acetylcholinesterase inhibitor, would enhance cognitive recovery beyond that of usual care in an acute rehabilitation facility. METHODS: This retrospective, longitudinal analysis included 55 patients who were non-randomly prescribed donepezil during acute care and compared them to 74 patients who received usual rehabilitation treatment...
May 8, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29735513/a-unifying-theory-for-cognitive-abnormalities-in-functional-neurological-disorders-fibromyalgia-and-chronic-fatigue-syndrome-systematic-review
#14
REVIEW
Tiago Teodoro, Mark J Edwards, Jeremy D Isaacs
BACKGROUND: Functional cognitive disorder (FCD) describes cognitive dysfunction in the absence of an organic cause. It is increasingly prevalent in healthcare settings yet its key neuropsychological features have not been reported in large patient cohorts. We hypothesised that cognitive profiles in fibromyalgia (FM), chronic fatigue syndrome (CFS) and functional neurological disorders (FNDs) would provide a template for characterising FCD. METHODS: We conducted a systematic review of studies with cognition-related outcomes in FM, CFS and FND...
May 7, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29732941/measurement-of-cerebral-biomarkers-proving-traumatic-brain-injuries-in-post-mortem-body-fluids
#15
Benjamin Ondruschka, Monique Sieber, Holger Kirsten, Heike Franke, Jan Dressler
Until now, it is impossible to identify a fatal traumatic brain injury (TBI) before post-mortem radiological investigations or an autopsy take place. It would be preferable to have an additional diagnostic tool like post-mortem biochemistry to get greater insight into the pathological pathways and survival times after sustaining TBI. Cerebrospinal fluid (CSF) and serum samples of 84 autopsy cases were collected from forensic autopsies with post-mortem intervals (PMI) of up to 148 h. The cases were categorized into a fatal TBI case group (n=42) and non-TBI controls (n=42)...
May 5, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29732476/critical-thresholds-for-intracranial-pressure-vary-over-time-in-non-craniectomised-traumatic-brain-injury-patients
#16
Basil Nourallah, Frederick A Zeiler, Leanne Calviello, Peter Smielewski, Marek Czosnyka, David K Menon
BACKGROUND: Intracranial pressure (ICP)- and cerebral perfusion pressure (CPP)-guided therapy is central to neurocritical care for traumatic brain injury (TBI) patients. We sought to identify time-dependent critical thresholds for mortality and unfavourable outcome for ICP and CPP in non-craniectomised TBI patients. METHODS: This is a retrospective cohort study of 355 patients with moderate-to-severe TBI who received ICP monitoring and were managed without decompressive craniectomy in a tertiary hospital neurocritical care unit...
May 7, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29730351/traumatically-brain-injured-donors-and-the-impact-on-lung-transplant-survival
#17
Todd C Crawford, Cecillia Lui, J Trent Magruder, Alejandro Suarez-Pierre, Jinny S Ha, Robert S Higgins, Stephen R Broderick, Christian A Merlo, Bo S Kim, Errol L Bush
BACKGROUND: Concern has been raised over inferior lung transplant survival associated with traumatic brain injury (TBI) organ donors. Our purpose was to explore the relationship between TBI donors and lung transplant survival in the lung allocation score (LAS) era. METHODS: We queried the UNOS Scientific Registry of Transplant Recipients and identified all adult (≥18 years) lung transplants performed from May 4, 2005 to December 31, 2015. Recipients were dichotomized based on donor cause of death, TBI versus non-TBI, propensity scored across eight variables (final LAS, pre-transplant ICU admission, pre-transplant ECMO, donor age ≥50 years, CMV antibody recipient-/donor+, ischemia time, annual center transplant volume, single versus double lung transplant), and matched 1:1 without replacement...
May 3, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29720544/advantages-of-virtual-reality-in-the-rehabilitation-of-balance-and-gait-systematic-review
#18
REVIEW
Desiderio Cano Porras, Petra Siemonsma, Rivka Inzelberg, Gabriel Zeilig, Meir Plotnik
BACKGROUND: Virtual reality (VR) has emerged as a therapeutic tool facilitating motor learning for balance and gait rehabilitation. The evidence, however, has not yet resulted in standardized guidelines. The aim of this study was to systematically review the application of VR-based rehabilitation of balance and gait in 6 neurologic cohorts, describing methodologic quality, intervention programs, and reported efficacy. METHODS: This study follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses...
May 2, 2018: Neurology
https://www.readbyqxmd.com/read/29717626/the-moderating-effect-of-ankk1-on-the-association-of-family-environment-with-longitudinal-executive-function-following-traumatic-brain-injury-in-early-childhood-a-preliminary-study
#19
Julia Smith-Paine, Shari L Wade, Amery Treble-Barna, Nanhua Zhang, Huaiyu Zang, Lisa J Martin, Keith Owen Yeates, H Gerry Taylor, Brad G Kurowski
This study examined whether the ankyrin repeat and kinase domain containing 1 gene (ANKK1) C/T single-nucleotide polymorphism (SNP) rs1800497 moderated the association of family environment with long-term executive function (EF) following traumatic injury in early childhood. Caregivers of children with traumatic brain injury (TBI) and children with orthopedic injury (OI) completed the Behavior Rating Inventory of Executive Function (BRIEF) at post injury visits. DNA was collected to identify the rs1800497 genotype in the ANKK1 gene...
May 2, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29708447/prevalence-and-predictors-of-tobacco-smoking-in-veterans-and-service-members-following-traumatic-brain-injury-rehabilitation-a-va-tbims-study
#20
Marc A Silva, Heather G Belanger, Kristen Dams-O'Connor, Xinyu Tang, Tamara McKenzie-Hartman, Risa Nakase-Richardson
OBJECTIVE: To identify prevalence and predictors of tobacco smoking among veterans and military service members (V/SM) with traumatic brain injury (TBI) admitted for rehabilitation. METHODS: Participants were drawn from the VA TBI Model Systems multicentre longitudinal research study. Tobacco smoking was assessed both preinjury and at 1- or 2-year post-TBI follow-up for 336 participants. RESULTS: Smoking prevalence was 32% preinjury and 28% at follow-up...
April 30, 2018: Brain Injury: [BI]
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