Enrica Federti, Francesca Vinchi, Iana Iatcenko, Alessandra Ghigo, Alessandro Matte, Serge Cedrick Mbiandjeu Toya, Angela Siciliano, Deborah Chiabrando, Emanuela Tolosano, Steven Zebulon Vance, Veronica Riccardi, Immacolata Andolfo, Manuela Iezzi, Alessia Lamolinara, Achille Iolascon, Lucia De Franceschi
Cardiomyopathy deeply affects quality of life and mortality of patients with β-thalassemia or with transfusion dependent myelodysplastic syndromes. Recently, a link between Nrf2 activity and iron metabolism has been reported in liver ironoverload murine models. Here, we studied C57B6 as healthy control and Nrf2-/- male mice aged 4- and 12-months.11-months old wild-type (WT) and Nrf2-/- mice were fed with either standard diet or a diet containing 2.5% carbonyl-iron (IO) for 4 weeks. We show that Nrf2-/- mice develop an age dependent cardiomyopathy, characterized by severe oxidation, degradation of SERCA2A and iron accumulation...
January 26, 2023: Haematologica