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https://www.readbyqxmd.com/read/29909026/towards-using-fnirs-recordings-of-mental-arithmetic-for-the-detection-of-residual-cognitive-activity-in-patients-with-disorders-of-consciousness-doc
#1
Eva-Maria Kurz, Guilherme Wood, Silvia Erika Kober, Walter Schippinger, Gerald Pichler, Gernot Müller-Putz, Günther Bauernfeind
BACKGROUND: Recently, fNIRS has been proposed as a promising approach for awareness detection, and a possible method to establish basic communication in patients with disorders of consciousness (DOC). AIM: Using fNIRS, the present study evaluated the applicability of auditory presented mental-arithmetic tasks in this respect. METHODS: We investigated the applicability of active attention to serial subtractions for awareness detection in ten healthy controls (HC, 21-32 y/o), by comparing the measured patterns to patterns induced by self-performance of the same task...
June 14, 2018: Brain and Cognition
https://www.readbyqxmd.com/read/29908235/the-effect-of-antibiotics-on-social-aversion-following-early-life-inflammation
#2
Amanda C Kentner, Urma Khan, M MacRae, Scot E Dowd, Siyang Yan
Epidemiological evidence suggests that exposure to infection during early development increases the risk for neurodevelopmental disorders associated with symptoms such as a decreased desire to engage in social interactions. This disruption in social behavior can be modelled in animals by administering bacterial mimetics such as liposaccharide (LPS). However, when evaluating social interactions in the laboratory, attention is rarely directed on the reciprocal relationship as a whole, which is important as peers may drive social withdrawal...
June 13, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29908232/the-association-of-spinophilin-with-disks-large-associated-protein-3-sapap3-is-regulated-by-metabotropic-glutamate-receptor-mglur-5
#3
Cameron W Morris, Darryl S Watkins, Asma B Salek, Michael C Edler, Anthony J Baucum
Spinophilin is the most abundant protein phosphatase 1 targeting protein in the postsynaptic density of dendritic spines. Spinophilin associates with myriad synaptic proteins to regulate normal synaptic communication; however, the full complement of spinophilin interacting proteins and mechanisms regulating spinophilin interactions are unclear. Here we validate an association between spinophilin and the scaffolding protein, disks large-associated protein 3 (SAP90/PSD-95 associated protein 3; SAPAP3). Loss of SAPAP3 leads to obsessive-compulsive disorder (OCD)-like behaviors due to alterations in metabotropic glutamate receptor (mGluR) signaling...
June 13, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29907953/effectiveness-of-a-scerts-model-based-intervention-for-children-with-autism-spectrum-disorder-asd-in-hong-kong-a-pilot-study
#4
Lu Yu, Xiaoqin Zhu
A SCERTS model-based intervention with different durations (5-month vs. 10-month) was provided to 122 children with autism spectrum disorder (ASD) (age = 53.43 ± 9.05 months) in Hong Kong. Before and after the intervention, the children were assessed with the Chinese Psychoeducational Profile-Third Edition (CPEP-3) and the Developmental Assessment Chart (DAC). Educators and parents expressed their views toward the intervention in focus groups. Results showed that participating children improved significantly in their social communication and emotional behavior after the intervention, as measured by DAC and CPEP-3...
June 15, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29907890/impact-of-mast-cells-in-depression-disorder-inhibitory-effect-of-il-37-new-frontiers
#5
REVIEW
Pio Conti, Alessandro Caraffa, Gianpaolo Ronconi, Chiara M Conti, Spiros K Kritas, Filiberto Mastrangelo, Lucia Tettamanti, Theoharis C Theoharides
The purpose of this article is to study the involvement of inflammatory mast cells (MCs) in depression which may be inhibited by IL-37. We evaluate mast cells in depression on the basis of our previous experimental data, and using the most relevant studies reported in the literature. Dysfunction of mood, feelings, and thoughts is a major risk factor for several metabolic diseases and may influence the physiology of the body leading to depression. Depression, present in mastocytosis, is an important endogenous process that promotes the activation of meningeal cell receptors through a low-grade neurogenic chronic inflammation, and MCs...
June 16, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29906401/school-nurses-increasing-the-compliance-of-hygiene-routines-for-students-with-autism-spectrum-disorder
#6
Constance E McIntosh, Jessica Gundlach, Pamela Brelage, Storey Snyder
School nurses are essential healthcare providers to children with autism spectrum disorder (ASD). In providing this care, school nurses may need to accommodate the unique challenges that children with ASD may face, including but not limited to sensory sensitivities, communicative and social difficulties, difficulties remembering event sequencing and directions, and poor time management skills. The aim of this article is to provide school nurses and healthcare providers evidence-based interventions and strategies that they may use to increase the compliance of hygiene behaviors and routines for children with ASD...
June 1, 2018: NASN School Nurse
https://www.readbyqxmd.com/read/29905970/neurexin-superfamily-cell-membrane-receptor-contactin-associated-protein-like-4-cntnap4-is-involved-in-neural-egfl-like-1-nell-1-responsive-osteogenesis
#7
Chenshuang Li, Zhong Zheng, Pin Ha, Xiaoyan Chen, Wenlu Jiang, Shan Sun, Feng Chen, Greg Asatrian, Emily A Berthiaume, Jong Kil Kim, Eric C Chen, Shen Pang, Xinli Zhang, Kang Ting, Chia Soo
Contactin-associated protein-like 4 (Cntnap4) is a member of the neurexin superfamily of transmembrane molecules that have critical functions in neuronal cell communication. Cntnap4 knockout mice display decreased presynaptic gamma-aminobutyric acid (GABA) and increased dopamine release that is associated with severe, highly penetrant, repetitive, and perseverative movements commonly found in human autism spectrum disorder patients. However, no known function of Cntnap4 has been revealed besides the nervous system...
June 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29905912/oxidation-resistance-1-modulates-glycolytic-pathways-in-the-cerebellum-via-an-interaction-with-glucose-6-phosphate-isomerase
#8
Mattéa J Finelli, Teresa Paramo, Elisabete Pires, Brent J Ryan, Richard Wade-Martins, Philip C Biggin, James McCullagh, Peter L Oliver
Glucose metabolism is essential for the brain: it not only provides the required energy for cellular function and communication but also participates in balancing the levels of oxidative stress in neurons. Defects in glucose metabolism have been described in neurodegenerative disease; however, it remains unclear how this fundamental process contributes to neuronal cell death in these disorders. Here, we investigated the molecular mechanisms driving the selective neurodegeneration in an ataxic mouse model lacking oxidation resistance 1 (Oxr1) and discovered an unexpected function for this protein as a regulator of the glycolytic enzyme, glucose-6-phosphate isomerase (GPI/Gpi1)...
June 15, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29904907/systematic-review-and-guide-to-management-of-core-and-psychiatric-symptoms-in-youth-with-autism
#9
REVIEW
S H Ameis, C Kassee, P Corbett-Dick, L Cole, S Dadhwal, M-C Lai, J Veenstra-VanderWeele, C U Correll
OBJECTIVE: Evidence-based guidance of clinical decision-making for the management of Autism Spectrum Disorder (ASD) is lacking, particularly for co-occurring psychiatric symptoms. This review evaluates treatment evidence for six common symptom targets in children/adolescents with ASD and provides a resource to facilitate application of the evidence to clinical practice. METHOD: A systematic search identified randomized controlled trials (RCTs) and high-quality systematic reviews published between 2007 and 2016, focused on: social interaction/communication impairment, stereotypic/repetitive behaviours, irritability/agitation, attention-deficit/hyperactivity disorder symptoms, mood or anxiety symptoms, and sleep difficulties...
June 14, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29903615/neurotransmitter-modulation-by-the-gut-microbiota
#10
Philip Strandwitz
The gut microbiota - the trillions of bacteria that reside within the gastrointestinal tract - has been found to not only be an essential component immune and metabolic health, but also seems to influence development and diseases of the enteric and central nervous system, including motility disorders, behavioral disorders, neurodegenerative disease, cerebrovascular accidents, and neuroimmune-mediated disorders. By leveraging animal models, several different pathways of communication have been identified along the "gut-brain-axis" including those driven by the immune system, the vagus nerve, or by modulation of neuroactive compounds by the microbiota...
August 15, 2018: Brain Research
https://www.readbyqxmd.com/read/29903536/evaluation-of-psychometric-properties-of-voice-activity-and-participation-profile-vapp-a-spanish-version
#11
Rosa M Bermúdez-de-Alvear, Pablo Gálvez-Ruiz, A Ginés Martínez-Arquero, Sara Rando-Márquez, Elena Fernández-Contreras
OBJECTIVES: This study aimed to analyze the psychometric properties of the Spanish version of the Voice Activity and Participation Profile (SVAPP) questionnaire. STUDY DESIGN: A randomized, cross-sectional sampling strategy with controls was used. METHODS: Two samples with a total of 169 participants were analyzed, specifically 61 men (mean age 37.02) and 108 women (mean age 37.78). Of these participants, 112 were patients and 57 were controls...
June 11, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29902995/how-is-a-specialist-depression-service-effective-for-persistent-moderate-to-severe-depressive-disorder-a-qualitative-study-of-service-user-experience
#12
Louise Thomson, Marcus Barker, Catherine Kaylor-Hughes, Anne Garland, Rajini Ramana, Richard Morriss, Emily Hammond, Gail Hopkins, Sandra Simpson
BACKGROUND: A specialist depression service (SDS) offering collaborative pharmacological and cognitive behaviour therapy treatment for persistent depressive disorder showed effectiveness against depression symptoms versus usual community based multidisciplinary care in a randomised controlled trial (RCT) in specialist mental health services in England. However, there is uncertainty concerning how specialist depression services effect such change. The current study aimed to evaluate the factors which may explain the greater effectiveness of SDS compared to Treatment as Usual (TAU) by exploring the experience of the RCT participants...
June 15, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29902778/toxic-metal-loid-based-pollutants-and-their-possible-role-in-autism-spectrum-disorder
#13
REVIEW
Geir Bjørklund, Anatoly V Skalny, Md Mostafizur Rahman, Maryam Dadar, Heba A Yassa, Jan Aaseth, Salvatore Chirumbolo, Margarita G Skalnaya, Alexey A Tinkov
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction, verbal and non-verbal communication, and stereotypic behaviors. Many studies support a significant relationship between many different environmental factors in ASD etiology. These factors include increased daily exposure to various toxic metal-based environmental pollutants, which represent a cause for concern in public health. This article reviews the most relevant toxic metals, commonly found, environmental pollutants, i...
June 11, 2018: Environmental Research
https://www.readbyqxmd.com/read/29902634/interferon-gamma-transcript-detection-on-t-cells-based-on-magnetic-actuation-and-multiplex-double-tagging-electrochemical-genosensing
#14
Soledad Carinelli, Cristina Xufré, Mercè Martí, María Isabel Pividori
Interferon-γ is a proinflammatory cytokine, and its production is related with effective host defense against intracellular pathogens. Therefore, the level of interferon-γ is considered a good biomarker for intracellular infections. It is also useful for the assessment, treatment progression and follow-up of non-communicable diseases, including cancer and autoimmune disorders, among others. This work addresses the development of a novel interferon-γ release assay (IGRA) to evaluate the expression of interferon-γ transcripts as biomarker produced by isolated T cells, as a main advantage...
May 22, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29902351/validation-of-the-caregiver-skills-cask-scale-in-catalonia-concordance-between-caregivers-in-attitudes-and-behaviours
#15
Cristina Vintró-Alcaraz, Gemma Mestre-Bach, Trevor Steward, María Lozano-Madrid, Zaida Agüera, Susana Jiménez-Murcia, Anna M Pedraza, Eduardo Serrano-Troncoso, Ana E Ortiz García, Teresa Rangil, Eulalia Lorán, Jose Soriano-Pacheco, Laura Medrano-Puigdollers, Sara Bujalance-Arguijo, Gina Badia, Maria Luque, Gloria Tràfach, Osane Gómez, Joan Peña, Carme Fabra, Maria Teresa Plana, Reyes Raspall, Isabel Sánchez, Nadine Riesco, Roser Granero, Cristina Carretero-Jardí, Janet Treasure, Fernando Fernández-Aranda
OBJECTIVE: The aim of this study was to validate a Spanish version of the Caregiver Skills scale (CASK) in a sample of eating disorder (ED) caregivers. A further aim was to examine the concordance/discrepancy between them (namely, between the mothers and fathers of ED patients). METHOD: Two hundred sixty-five ED caregivers were recruited from ED centers in Catalonia, Spain. Confirmatory factor analyses was used to test the factorial structure of the CASK scale. Cronbach's α was used to measure internal consistency of the CASK scales...
July 2018: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29900549/using-patient-cases-to-educate-health-professionals-patients-institutions-and-society-the-swallowing-disorder-example
#16
Michaela Wagner-Menghin, Alexander Hirsch, Peter Pokieser
The problems and symptoms of patients are at the heart of medicine and pertinent to information, communication, and education. Patients present their problems to health professionals looking for relief and a cure, while institutions collect data about symptoms of patients and the way health professionals treated them to support society's care providers in administrating and managing care. The information on the problems of patients and the way health professionals treated them, which is gathered and stored in patient files, is valuable as educational material in the field of medicine...
June 13, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29899405/pharmacological-modulation-of-ampa-receptor-rescues-social-impairments-in-animal-models-of-autism
#17
Ji-Woon Kim, Kwanghoon Park, Ri Jin Kang, Edson Luck T Gonzales, Do Gyeong Kim, Hyun Ah Oh, Hana Seung, Mee Jung Ko, Kyoung Ja Kwon, Ki Chan Kim, Sung Hoon Lee, ChiHye Chung, Chan Young Shin
Autism spectrum disorder (ASD) is a neurodevelopmental disorder, featuring social communication deficit and repetitive/restricted behaviors as common symptoms. Its prevalence has continuously increased, but, till now, there are no therapeutic approaches to relieve the core symptoms, particularly social deficit. In previous studies, abnormal function of the glutamatergic neural system has been proposed as a critical mediator and therapeutic target of ASD-associated symptoms. Here, we investigated the possible roles of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) in autism symptoms using two well-known autistic animal models, Cntnap2 knockout (KO) mice and in utero valproic acid-exposed ICR (VPA) mice...
May 22, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29898212/association-of-autistic-traits-with-depression-from-childhood-to-age-18-years
#18
Dheeraj Rai, Iryna Culpin, Hein Heuvelman, Cecilia M K Magnusson, Peter Carpenter, Hannah J Jones, Alan M Emond, Stanley Zammit, Jean Golding, Rebecca M Pearson
Importance: Population-based studies following trajectories of depression in autism spectrum disorders (ASD) from childhood into early adulthood are rare. The role of genetic confounding and of potential environmental intermediaries, such as bullying, in any associations is unclear. Objectives: To compare trajectories of depressive symptoms from ages 10 to 18 years for children with or without ASD and autistic traits, to assess associations between ASD and autistic traits and an International Statistical Classification of Diseases, 10th Revision (ICD-10) depression diagnosis at age 18 years, and to explore the importance of genetic confounding and bullying...
June 13, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29897506/incidence-of-overwork-related-mental-disorders-and-suicide-in-japan
#19
T Yamauchi, T Sasaki, T Yoshikawa, S Matsumoto, M Takahashi
Background: Mental disorders and suicide resulting from overwork or work-related stress have become major occupational health issues worldwide, particularly in Asian countries. However, no studies have reported incidence rates of mental disorders and suicide by sex, age group and industry, using a national database containing all cases involving compensation in Asian countries. Aims: The present study examined incidence rates of occupational mental disorders and suicide by sex, age group and industry using a database containing all cases involving compensation for mental disorders and suicide in Japan over a 5-year period...
June 12, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29897166/effectiveness-of-information-and-communication-technologies-interventions-to-increase-mental-health-literacy-a-systematic-review
#20
REVIEW
Jing Ling Tay, Yi Fen Tay, Piyanee Klainin-Yobas
AIM: Most mental health conditions affect adolescent and young adults. The onset of many mental disorders occurs in the young age. This is a critical period to implement interventions to enhance mental health literacy (MHL) and to prevent the occurrence of mental health problems. This systematic review examined the effectiveness of information and communication technologies interventions on MHL (recognition of conditions, stigma and help-seeking). METHODS: The authors searched for both published and unpublished studies...
June 13, 2018: Early Intervention in Psychiatry
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