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https://www.readbyqxmd.com/read/29220541/yoga-for-stroke-rehabilitation
#1
REVIEW
Maggie Lawrence, Francisco T Celestino Junior, Hemilianna Hs Matozinho, Lindsay Govan, Jo Booth, Jane Beecher
BACKGROUND: Stroke is a major health issue and cause of long-term disability and has a major emotional and socioeconomic impact. There is a need to explore options for long-term sustainable interventions that support stroke survivors to engage in meaningful activities to address life challenges after stroke. Rehabilitation focuses on recovery of function and cognition to the maximum level achievable, and may include a wide range of complementary strategies including yoga.Yoga is a mind-body practice that originated in India, and which has become increasingly widespread in the Western world...
December 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29216607/frequency-of-risk-factors-and-coexisting-abnormalities-in-a-population-of-egyptian-children-with-autism-spectrum-disorder
#2
Nagwa Abdel Meguid, Neveen Hassan Nashaat, Heba S Hashem, Mai M Khalil
BACKGROUND: Many risk factors interact together during the critical period of development and govern the future phenotype of autism spectrum disorder (ASD). Furthermore, co-occurring abnormalities among individuals with ASD vary a lot so as their abilities. AIM OF WORK: To investigate possible risk factors and to determine the prevalence of coexisting abnormalities in a sample of Egyptian ASD children and their influence on the severity and their communication performance...
December 1, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29215326/the-role-of-fabp5-in-radiation-induced-human-skin-fibrosis
#3
Jianyuan Song, Huojun Zhang, Zhenyu Wang, Wanglei Xu, Li Zhong, Jinming Cao, Jianfeng Yang, Ye Tian, Daojiang Yu, Jiang Ji, Jianping Cao, Shuyu Zhang
Radiation-induced skin fibrosis is a detrimental and chronic disorder that occurs after radiation exposure. The molecular changes underlying the pathogenesis of radiation-induced fibrosis of human skin have not been extensively reported. Technical advances in proteomics have enabled exploration of the biomarkers and molecular pathogenesis of radiation-induced skin fibrosis, with the potential to broaden our understanding of this disease. In this study, we compared protein expression in radiation-induced fibrotic human skin and adjacent normal tissues using iTRAQ-based proteomics technology...
December 7, 2017: Radiation Research
https://www.readbyqxmd.com/read/29214153/alzheimer-s-disease-diagnosis-discrepancy-between-clinical-neuroimaging-and-cerebrospinal-fluid-biomarkers-criteria-in-an-italian-cohort-of-geriatric-outpatients-a-retrospective-cross-sectional-study
#4
Giulia A M Dolci, Sarah Damanti, Valeria Scortichini, Alessandro Galli, Paolo D Rossi, Carlo Abbate, Beatrice Arosio, Daniela Mari, Andrea Arighi, Giorgio G Fumagalli, Elio Scarpini, Silvia Inglese, Maura Marcucci
Background: The role of cerebrospinal fluid (CSF) biomarkers, and neuroimaging in the diagnostic process of Alzheimer's disease (AD) is not clear, in particular in the older patients. Objective: The aim of this study was to compare the clinical diagnosis of AD with CSF biomarkers and with cerebrovascular damage at neuroimaging in a cohort of geriatric patients. Methods: Retrospective analysis of medical records of ≥65-year-old patients with cognitive impairment referred to an Italian geriatric outpatient clinic, for whom the CSF concentration of amyloid-β (Aβ), total Tau (Tau), and phosphorylated Tau (p-Tau) was available...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29213525/motor-learning-characterization-in-people-with-autism-spectrum-disorder-a-systematic-review
#5
Íbis Ariana Peña de Moraes, Thais Massetti, Tânia Brusque Crocetta, Talita Dias da Silva, Lilian Del Ciello de Menezes, Carlos Bandeira de Mello Monteiro, Fernando Henrique Magalhães
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder primarily characterized by deficits in social interaction, communication and implicit skill learning. OBJECTIVE: To analyse the results of research on "motor learning" and the means used for measuring "autistic disorder". METHODS: A systematic literature search was done using Medline/PubMed, Web of Science, BVS (virtual health library), and PsycINFO. We included articles that contained the keywords "autism" and "motor learning"...
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29212345/a-pilot-investigation-of-an-ios-based-app-for-toilet-training-children-with-autism-spectrum-disorder
#6
Daniel W Mruzek, Stephen McAleavey, Whitney A Loring, Eric Butter, Tristram Smith, Erin McDonnell, Lynne Levato, Courtney Aponte, Rebekah P Travis, Rachel E Aiello, Cora M Taylor, Jonathan W Wilkins, Patricia Corbett-Dick, Dianne M Finkelstein, Alyssa M York, Katherine Zanibbi
We developed an iOS-based app with a transmitter/disposable sensor and corresponding manualized intervention for children with autism spectrum disorder. The app signaled the onset of urination, time-stamped accidents for analysis, reminded parents to reinforce intervals of continence, provided a visual outlet for parents to communicate reinforcement, and afforded opportunity for timely feedback from clinicians. We compared this intervention with an intervention that uses standard behavioral treatment in a pilot randomized controlled trial of 33 children with autism spectrum disorder aged 3-6 years with urinary incontinence...
December 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29212005/desmoglein-3-order-and-dynamics-in-desmosomes-determined-by-fluorescence-polarization-microscopy
#7
Emily I Bartle, Tara M Urner, Siddharth S Raju, Alexa L Mattheyses
Desmosomes are macromolecular cell-cell junctions that provide adhesive strength in epithelial tissue. Desmosome function is inseparably linked to structure, and it is hypothesized that the arrangement, or order, of desmosomal cadherins in the intercellular space is critical for adhesive strength. However, due to desmosome size, molecular complexity, and dynamics, the role that order plays in adhesion is challenging to study. Herein, we present an excitation resolved fluorescence polarization microscopy approach to measure the spatiotemporal dynamics of order and disorder of the desmosomal cadherin desmoglein 3 (Dsg3) in living cells...
December 5, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29211740/a-systematic-review-and-meta-analysis-of-comprehensive-interventions-for-pre-school-children-with-autism-spectrum-disorder-asd
#8
Yoshiyuki Tachibana, Celine Miyazaki, Erika Ota, Rintaro Mori, Yeonhee Hwang, Eriko Kobayashi, Akiko Terasaka, Julian Tang, Yoko Kamio
BACKGROUND: There has an increasing number of published trials on psychosocial intervention programmes for pre-school children with autism spectrum disorder (ASD). To achieve better quality of unbiased evidence for the effectiveness of ASD interventions, it is necessary to conduct a comprehensive review that covers studies with adequate quality standards, such as randomised controlled trials (RCTs), and different types of intervention In this study, we categorize interventions for ASD as behavioural, social-communication focused, and multimodal developmental based on Howlin's classification of early interventions for children with ASD...
2017: PloS One
https://www.readbyqxmd.com/read/29210643/adipokines-and-myokines-a-pivotal-role-in-metabolic-and-cardiovascular-disorders
#9
Hye Soo Chung, Kyung Mook Choi
Obesity induces an imbalance in the expression and secretion of several cytokines, which contributes to the development of metabolic and cardiovascular disorders. On the contrary, skeletal muscle is known to have a role in reversing the detrimental impact of obesity. It has been established that adipose tissue acts as an endocrine organ that secretes proinflammatory and anti-inflammatory adipokines. Similarly, skeletal muscle produces secretory molecules, called myokines, from contracting muscle fibers. Myokines were recently recognized as beneficial modulators of obesity, metabolic syndrome, and type 2 diabetes...
December 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29209272/a-european-perspective-on-auditory-processing-disorder-current-knowledge-and-future-research-focus
#10
Vasiliki Vivian Iliadou, Martin Ptok, Helen Grech, Ellen Raben Pedersen, André Brechmann, Naïma Deggouj, Christiane Kiese-Himmel, Mariola Śliwińska-Kowalska, Andreas Nickisch, Laurent Demanez, Evelyne Veuillet, Hung Thai-Van, Tony Sirimanna, Marina Callimachou, Rosamaria Santarelli, Sandra Kuske, Jose Barajas, Mladen Hedjever, Ozlem Konukseven, Dorothy Veraguth, Tone Stokkereit Mattsson, Jorge Humberto Martins, Doris-Eva Bamiou
Current notions of "hearing impairment," as reflected in clinical audiological practice, do not acknowledge the needs of individuals who have normal hearing pure tone sensitivity but who experience auditory processing difficulties in everyday life that are indexed by reduced performance in other more sophisticated audiometric tests such as speech audiometry in noise or complex non-speech sound perception. This disorder, defined as "Auditory Processing Disorder" (APD) or "Central Auditory Processing Disorder" is classified in the current tenth version of the International Classification of diseases as H93...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29208729/persistent-postural-perceptual-dizziness-pppd-a-common-characteristic-and-treatable-cause-of-chronic-dizziness
#11
REVIEW
Stoyan Popkirov, Jeffrey P Staab, Jon Stone
Persistent postural-perceptual dizziness (PPPD) is a newly defined diagnostic syndrome that unifies key features of chronic subjective dizziness, phobic postural vertigo and related disorders. It describes a common chronic dysfunction of the vestibular system and brain that produces persistent dizziness, non-spinning vertigo and/or unsteadiness. The disorder constitutes a long-term maladaptation to a neuro-otological, medical or psychological event that triggered vestibular symptoms, and is usefully considered within the spectrum of other functional neurological disorders...
December 5, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29206311/the-expanding-life-and-functions-of-osteogenic-cells-from-simple-bone-making-cells-to-multifunctional-cells-and-beyond
#12
REVIEW
Pierre J Marie, Martine Cohen-Solal
During the last three decades, important progresses in bone cell biology and in human and mouse genetics led to major advances in our understanding of the life and functions of cells of the osteoblast lineage. Previously unrecognized sources of osteogenic cells have been identified. Novel cellular and molecular mechanisms controlling osteoblast differentiation and senescence have been determined. New mechanisms of communications between osteogenic cells, osteocytes, osteoclasts and chondrocytes, as well as novel links between osteogenic cells and blood vessels have been identified...
December 5, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29205605/coaching-parents-to-assess-and-treat-self-injurious-behaviour-via-telehealth
#13
S S Benson, A F Dimian, M Elmquist, J Simacek, J J McComas, F J Symons
The application of telehealth technology to conduct functional analysis (FA) and functional communication training (FCT) is emerging for children with developmental disabilities and behaviour support needs. The current study was designed to extend FA + FCT for self-injurious behaviour by using telehealth in home with parents as interventionists receiving real-time remote coaching. Two families with school-aged boys with developmental disabilities associated with intellectual disability participated, one with cerebral palsy and the other with autism spectrum disorder...
December 5, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29204811/impact-of-a-patient-facing-enhanced-genomic-results-report-to-improve-understanding-engagement-and-communication
#14
Janet L Williams, Alanna Kulchak Rahm, Doris T Zallen, Heather Stuckey, Kara Fultz, Audrey L Fan, Michele Bonhag, Lynn Feldman, Michael M Segal, Marc S Williams
"The objective of this study was to" test the effectiveness of an enhanced genomic report on patient-centered outcome domains including communication, engagement and satisfaction. "Study design utilized" a prospective, randomized, mixed-methods desctiptive study of a whole genome sequencing results report, GenomeCOMPASS™, that was accessed by providers through the electronic health record and by patients through the associated patient portal. "The study was set in" an integrated healthcare delivery system in central Pennsylvania...
December 4, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29204259/early-development-of-infants-with-neurofibromatosis-type-1-a-case-series
#15
Anna May Kolesnik, Emily Jane Harrison Jones, Shruti Garg, Jonathan Green, Tony Charman, Mark Henry Johnson
Background: Prospective studies of infants at familial risk for autism spectrum disorder (ASD) have yielded insights into the earliest signs of the disorder but represent heterogeneous samples of unclear aetiology. Complementing this approach by studying cohorts of infants with monogenic syndromes associated with high rates of ASD offers the opportunity to elucidate the factors that lead to ASD. Methods: We present the first report from a prospective study of ten 10-month-old infants with neurofibromatosis type 1 (NF1), a monogenic disorder with high prevalence of ASD or ASD symptomatology...
2017: Molecular Autism
https://www.readbyqxmd.com/read/29203828/foxp2-variation-in-great-ape-populations-offers-insight-into-the-evolution-of-communication-skills
#16
Nicky Staes, Chet C Sherwood, Katharine Wright, Marc de Manuel, Elaine E Guevara, Tomas Marques-Bonet, Michael Krützen, Michael Massiah, William D Hopkins, John J Ely, Brenda J Bradley
The gene coding for the forkhead box protein P2 (FOXP2) is associated with human language disorders. Evolutionary changes in this gene are hypothesized to have contributed to the emergence of speech and language in the human lineage. Although FOXP2 is highly conserved across most mammals, humans differ at two functional amino acid substitutions from chimpanzees, bonobos and gorillas, with an additional fixed substitution found in orangutans. However, FOXP2 has been characterized in only a small number of apes and no publication to date has examined the degree of natural variation in large samples of unrelated great apes...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29203706/heat-shock-proteins-as-modulators-and-therapeutic-targets-of-chronic-disease-an-integrated-perspective
#17
Adrienne L Edkins, John T Price, A Graham Pockley, Gregory L Blatch
Many heat shock proteins (HSPs) are essential to survival as a consequence of their role as molecular chaperones, and play a critical role in maintaining cellular proteostasis by integrating the fundamental processes of protein folding and degradation. HSPs are arguably among the most prominent classes of proteins that have been broadly linked to many human disorders, with changes in their expression profile and/or intracellular/extracellular location now being described as contributing to the pathogenesis of a number of different diseases...
January 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29203509/protocol-for-a-feasibility-study-and-randomised-pilot-trial-of-a-low-intensity-psychological-intervention-for-depression-in-adults-with-autism-the-autism-depression-trial-adept
#18
Ailsa Russell, Kate Cooper, Stephen Barton, Ian Ensum, Daisy Gaunt, Jeremy Horwood, Barry Ingham, David Kessler, Chris Metcalfe, Jeremy Parr, Dheeraj Rai, Nicola Wiles
INTRODUCTION: High rates of co-occurring depression are reported in autism spectrum disorder (ASD), a neurodevelopmental condition characterised by social communication impairments and repetitive behaviours. Cognitive-behavioural interventions adapted for ASD have been effective for anxiety problems. There have been evaluation studies of group cognitive-behavioural therapy for co-occurring depression, but no randomised trials investigating low-intensity psychological interventions as recommended in clinical guidelines for mild-moderate depression...
December 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29203377/proposed-terminology-and-classification-of-pre-malignant-neoplastic-conditions-a-consensus-proposal
#19
REVIEW
Peter Valent, Cem Akin, Michel Arock, Christoph Bock, Tracy I George, Stephen J Galli, Jason Gotlib, Torsten Haferlach, Gregor Hoermann, Olivier Hermine, Ulrich Jäger, Lukas Kenner, Hans Kreipe, Ravindra Majeti, Dean D Metcalfe, Alberto Orfao, Andreas Reiter, Wolfgang R Sperr, Philipp B Staber, Karl Sotlar, Charles Schiffer, Giulio Superti-Furga, Hans-Peter Horny
Cancer evolution is a step-wise non-linear process that may start early in life or later in adulthood, and includes pre-malignant (indolent) and malignant phases. Early somatic changes may not be detectable or are found by chance in apparently healthy individuals. The same lesions may be detected in pre-malignant clonal conditions. In some patients, these lesions may never become relevant clinically whereas in others, they act together with additional pro-oncogenic hits and thereby contribute to the formation of an overt malignancy...
November 26, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29202172/interprofessional-collaboration-of-dental-hygiene-and-communication-sciences-disorders-students-to-meet-oral-health-needs-of-children-with-autism
#20
Kelly L Anderson, Trisha L Self, Brandi N Carlson
PURPOSE: This pilot project was intended to introduce an authentic interprofessional education experience with students from Communication Sciences & Disorders (CSD) and Dental Hygiene (DH) to develop and apply strategies to assist children diagnosed with autism spectrum disorder (ASD) to decrease their anxiety and improve their ability to participate in an oral screening and prophylaxis appointment. The second purpose was for students to learn each other's scope of practice. METHODS: Four children diagnosed with ASD were identified as having dental anxiety and unmet dental needs...
2017: Journal of Allied Health
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