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Prostate cancer mortality epidemiology

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https://www.readbyqxmd.com/read/27908234/sustained-early-disruption-of-mitochondrial-function-contributes-to-arsenic-induced-prostate-tumorigenesis
#1
B Singh, M Kulawiec, K M Owens, A Singh, K K Singh
Arsenic is a well-known human carcinogen that affects millions of people worldwide, but the underlying mechanisms of carcinogenesis are unclear. Several epidemiological studies have suggested increased prostate cancer incidence and mortality due to exposure to arsenic. Due to lack of an animal model of arsenic-induced carcinogenesis, we used a prostate epithelial cell culture model to identify a role for mitochondria in arsenic-induced prostate cancer. Mitochondrial morphology and membrane potential was impacted within a few hours of arsenic exposure of non-neoplastic prostate epithelial cells...
October 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/27880795/the-association-of-fatty-acid-levels-and-gleason-grade-among-men-undergoing-radical-prostatectomy
#2
Zhiguo Zhao, Lael Reinstatler, Zachary Klaassen, Yi Xu, Xiaoyu Yang, Rabii Madi, Martha K Terris, Steven Y Qian, Uddhav Kelavkar, Kelvin A Moses
BACKGROUND: Epidemiological data suggest that omega-6 (ω-6) fatty acids (FAs) may be associated with cancer incidence and/or cancer mortality, whereas ω-3 FAs are potentially protective. We examined the association of the ratio of ω-6 to ω-3 FA (ω-6:ω-3) and individual FA components with pathological results among men with prostate cancer (PCa) undergoing radical prostatectomy. METHODS: Sixty-nine men were included in the study. Components of ω-6 (linoleic acid (LA), arachidonic acid (AA), and dihomo-γ-linolenic acid (DGLA)) and ω-3 (docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)) were analyzed by liquid chromatography/mass selective detector separation...
2016: PloS One
https://www.readbyqxmd.com/read/27859019/the-impact-of-health-insurance-on-cancer-care-in-disadvantaged-communities
#3
Zaid M Abdelsattar, Samantha Hendren, Sandra L Wong
BACKGROUND: Individuals from disadvantaged communities are among the millions of uninsured Americans gaining insurance under the Affordable Care Act. The extent to which health insurance can mitigate the effects of the social determinants of health on cancer care is unknown. METHODS: This study linked the Surveillance, Epidemiology, and End Results registries to US Census data to study patients diagnosed with the 4 leading causes of cancer deaths between 2007 and 2011...
November 14, 2016: Cancer
https://www.readbyqxmd.com/read/27836248/a-review-for-clinicians-prostate-cancer-and-the-antineoplastic-properties-of-metformin
#4
REVIEW
Stephen J Hankinson, Mina Fam, Nitin N Patel
OBJECTIVES: Metformin has numerous antineoplastic effects including an AMP-activated protein kinase-dependent mechanism, AMP-activated protein kinase-independent mechanisms, alteration of insulin and insulin-like growth factor signaling pathways, and suppression of androgen signaling pathways that trigger prostate cancer growth and proliferation. In contrast to other malignancies that are associated with increased incidence among patients with obesity and type II diabetes mellitus (T2DM), epidemiological studies suggest that obesity and T2DM may impart a protective effect on prostate cancer incidence by creating a set of metabolic conditions that lower androgen levels...
November 8, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27738762/molecular-pathological-epidemiology-new-developing-frontiers-of-big-data-science-to-study-etiologies-and-pathogenesis
#5
Tsuyoshi Hamada, NaNa Keum, Reiko Nishihara, Shuji Ogino
Molecular pathological epidemiology (MPE) is an integrative field that utilizes molecular pathology to incorporate interpersonal heterogeneity of a disease process into epidemiology. In each individual, the development and progression of a disease are determined by a unique combination of exogenous and endogenous factors, resulting in different molecular and pathological subtypes of the disease. Based on "the unique disease principle," the primary aim of MPE is to uncover an interactive relationship between a specific environmental exposure and disease subtypes in determining disease incidence and mortality...
October 13, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27734240/sleep-disruption-chronotype-shift-work-and-prostate-cancer-risk-and-mortality-a-30-year-prospective-cohort-study-of-finnish-twins
#6
Barbra A Dickerman, Sarah C Markt, Markku Koskenvuo, Christer Hublin, Eero Pukkala, Lorelei A Mucci, Jaakko Kaprio
PURPOSE: Sleep disruption and shift work have been associated with cancer risk, but epidemiologic evidence for prostate cancer remains limited. We aimed to prospectively investigate the association between midlife sleep- and circadian-related parameters and later prostate cancer risk and mortality in a population-based cohort of Finnish twins. METHODS: Data were drawn from the Older Finnish Twin Cohort and included 11,370 twins followed from 1981 to 2012. Over the study period, 602 incident cases of prostate cancer and 110 deaths from prostate cancer occurred...
November 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27720782/comparative-effectiveness-of-cancer-control-and-survival-after-robot-assisted-versus-open-radical-prostatectomy
#7
Jim C Hu, Padraic O'Malley, Bilal Chughtai, Abby Isaacs, Jialin Mao, Jason D Wright, Dawn Hershman, Art Sedrakyan
PURPOSE: Robot-assisted surgery has been rapidly adopted in the U.S. for prostate cancer. Its adoption has been driven by market forces and patient preference, and debate continues regarding whether it offers improved outcomes to justify the higher cost relative to open surgery. We examined the comparative effectiveness of robot-assisted vs open radical prostatectomy in cancer control and survival in a nationally representative population. MATERIALS AND METHODS: This population based observational cohort study of patients with prostate cancer undergoing robot-assisted radical prostatectomy and open radical prostatectomy during 2003 to 2012 used data captured in the SEER (Surveillance, Epidemiology, and End Results)-Medicare linked database...
October 5, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27685925/incidence-mortality-and-epidemiological-aspects-of-cancers-in-iran-differences-with-the-world-data
#8
Zeinab Almasi, Abdollah Mohammadian-Hafshejani, Hamid Salehiniya
PURPOSE: No comprehensive study of cancer incidence and mortality exists in Iran. This study aimed to evaluate the incidence, mortality and epidemiological aspects of cancers in our country. METHODS: In this study, information of cancer incidence and mortality in Iran was retrieved from International Cancer Registry data and reported by numbers, crude and standardized incidence and mortality rates. Cancer incidence and mortality in Iran were mapped and compared with neighboring countries and the world...
July 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27666299/therapeutic-management-of-bone-metastasis-in-prostate-cancer-an-update
#9
Fable Zustovich, Davide Pastorelli
Bone metastases affect the majority of patients with castration-resistant prostate cancer (CRPC), resulting in significant morbidity and mortality. This review describes the current therapies available for the management of CRPC patients with bone metastases. Areas covered: Studies on the use of currently available therapeutic approaches for palliating pain, delaying skeletal-related events (SREs) and prolonging survival in CRPC patients with bone metastases have been examined. PubMed database was searched in May 2016 starting with the following keywords: ('castration-resistant prostate cancer' OR 'CRPC') AND 'bone metastases', and approximately 270 results were retrieved...
October 6, 2016: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/27644231/prostate-cancer-trends-in-asia
#10
Hideyuki Akaza, Mizuki Onozawa, Shiro Hinotsu
INTRODUCTION: Differences in the incidence and mortality rates for prostate cancer between East and West are clearly defined, with higher rates in the West and lower rates in the East. Treatment methods are generally selected in accordance with general practice guidelines, but the current reality in Asia is that there is not sufficient clinical data to set Asia-specific guidelines for treatment. This leads to a situation whereby for the large part guidelines based on scientific evidence accumulated in Western countries are followed, but from time to time cases are encountered when such guidelines may not be considered to be the most appropriate for the case at hand...
September 19, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27622278/prostate-cancer-in-brazil-and-latin-america-epidemiology-and-screening
#11
REVIEW
Rafael Rocha Tourinho-Barbosa, Antonio Carlos Lima Pompeo, Sidney Glina
INTRODUCTION: Prostate cancer is one of the tumors with higher incidence and mortality among men in the World. Epidemiological data are influenced by life expectancy of population, available diagnostic methods, correct collection of data and quality of health services. Screening of the disease is not standardized around the World. Up till now there is no consensus about the risks versus benefits of early detection. There are still missing data about this pathology in Latin America. OBJECTIVE: to revise current epidemiologic situation and early diagnosis policies of prostate cancer in Brazil and Latin America...
November 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27619665/prostate-cancer-screening-in-brazil-should-it-be-done-or-not
#12
REVIEW
Wilson F S Busato, Gilberto L Almeida
The use of PSA in the screening, detection and prognosis of prostate cancer (PCa) has revolutionized the diagnosis and treatment of this disorder with an increase in detection rates and PCa organ-confined. Despite these benefits and ease of implementation, tracking PCa remains a matter of great controversy. We conducted a literature review and demographic and epidemiological data in Brazil feeling to assess the current state of screening and whether there is justification for population programs. the diferences are valued between developed and underdeveloped countries as the incidence, mortality, screening and access to health...
November 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27582605/epidemiology-of-prostate-and-testicular-cancer
#13
REVIEW
Pauline Filippou, James E Ferguson, Matthew E Nielsen
Prostate and testicular cancers account for a large percentage of cancer morbidity in men in the United States and worldwide due to high prevalence rates that continue to grow. Patterns of incidence and mortality vary greatly in both cancers among men of different age groups, ethnicities, and geographic locations. This article summarizes the incidence, prognosis, and risk factors of both prostate and testicular cancers, globally and in the United States.
September 2016: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/27557370/the-burden-of-cancer-in-mexico-1990-2013
#14
Héctor Gómez-Dantés, Héctor Lamadrid-Figueroa, Lucero Cahuana-Hurtado, Omar Silverman-Retana, Pablo Montero, María Cecilia González-Robledo, Christina Fitzmaurice, Amanda Pain, Christine Allen, Daniel J Dicker, Hannah Hamavid, Alan López, Christopher Murray, Mohsen Naghavi, Rafael Lozano
OBJECTIVE: To analyze mortality and incidence for 28 cancers by deprivation status, age and sex from 1990 to 2013. MATERIALS AND METHODS: The data and methodological approaches provided by the Global Burden of Disease (GBD 2013) were used. RESULTS: Trends from 1990 to 2013 show important changes in cancer epidemiology in Mexico. While some cancers show a decreasing trend in incidence and mortality (lung, cervical) others emerge as relevant health priorities (prostate, breast, stomach, colorectal and liver cancer)...
April 2016: Salud Pública de México
https://www.readbyqxmd.com/read/27551550/vitamin-d-and-urological-cancers
#15
REVIEW
Wojciech Krajewski, Mateusz Dzięgała, Anna Kołodziej, Janusz Dembowski, Romuald Zdrojowy
INTRODUCTION: Vitamin D controls calcium and phosphate homeostasis. Additionally, it has been proven that vitamin D is an important modulator of cellular differentiation and proliferation in a number of normal and malignant cells. Vitamin D can regulate proliferation, apoptosis, and cell adhesion at the tumor cell level. It also modifies tumor angiogenesis, invasion, and metastasis and also decreases oxidative DNA damage. MATERIAL AND METHODS: The Medline and Web of Science databases were searched without time limit on October 2015 using the terms 'vitamin D' in conjunction with 'kidney cancer', 'bladder cancer', 'prostate cancer', and 'testis cancer'...
2016: Central European Journal of Urology
https://www.readbyqxmd.com/read/27518576/prostate-cancer-progression-and-mortality-a-review-of-diet-and-lifestyle-factors
#16
Sam F Peisch, Erin L Van Blarigan, June M Chan, Meir J Stampfer, Stacey A Kenfield
PURPOSE: To review and summarize evidence on the role of diet and lifestyle factors and prostate cancer progression, with a specific focus on habits after diagnosis and the risk of subsequent disease recurrence, progression, or death. METHODS: Given the well-documented heterogeneity of prostate cancer and the long survivorship of the majority of diagnoses, our goal was to summarize and describe modifiable risk factors for clinically relevant prostate cancer. We focused where possible on epidemiologic studies of post-diagnostic habits and prostate cancer progression, defined as recurrence (e...
August 12, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27478167/survival-after-conservative-management-versus-external-beam-radiation-therapy-in-elderly-patients-with-localized-prostate-cancer
#17
Paolo Dell'Oglio, Katharina Boehm, Vincent Trudeau, Zhe Tian, Alessandro Larcher, Sami-Ramzi Leyh-Bannurah, Marco Moschini, Umberto Capitanio, Shahrokh F Shariat, Alberto Briganti, Francesco Montorsi, Fred Saad, Pierre I Karakiewicz
PURPOSE: To compare survival in elderly men with clinically localized prostate cancer (PCa) according to treatment type, defined as radiation therapy (RT) with or without androgen deprivation therapy (ADT) versus conservative management (observation). METHODS AND MATERIALS: In the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database, we identified 23,790 patients aged 80 years or more with clinically localized PCa treated with either RT or observation between 1991 and 2009...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27407093/physical-activity-and-cancer-outcomes-a-precision-medicine-approach
#18
Christine M Friedenreich, Heather K Neilson, Megan S Farris, Kerry S Courneya
There is increasing interest in applying a precision medicine approach to understanding exercise as a potential treatment for cancer. We aimed to inform this new approach by appraising epidemiologic literature relating post-diagnosis physical activity to cancer outcomes overall and by molecular/genetic subgroups. Across 26 studies of breast, colorectal and prostate cancer patients, there was a 37% reduction in risk of cancer-specific mortality, comparing the most versus the least active patients (pooled relative risk=0...
July 12, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27397504/food-based-natural-products-for-cancer-management-is-the-whole-greater-than-the-sum-of-the-parts
#19
REVIEW
Suleman S Hussain, Addanki P Kumar, Rita Ghosh
The rise in cancer incidence and mortality in developing countries together with the human and financial cost of current cancer therapy mandates a closer look at alternative ways to overcome this burgeoning global healthcare problem. Epidemiological evidence for the association between cancer and diet and the long latency of most cancer progression have led to active exploration of whole and isolated natural chemicals from different naturally occurring substances in various preclinical and clinical settings...
October 2016: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/27377470/risk-of-second-primary-malignancies-among-cancer-survivors-in-the-united-states-1992-through-2008
#20
Nicholas Donin, Christopher Filson, Alexandra Drakaki, Hung-Jui Tan, Alex Castillo, Lorna Kwan, Mark Litwin, Karim Chamie
BACKGROUND: In the current study, the authors attempted to describe the incidence, most common sites, and mortality of second primary malignancies among survivors of common cancers. METHODS: The authors identified patients aged ≥18 years who were diagnosed with a primary malignancy from the 10 most common cancer sites (prostate, breast, lung, colon, rectum, bladder, uterus, kidney, melanoma, and non-Hodgkin lymphoma) between 1992 and 2008 from Surveillance, Epidemiology, and End Results data...
October 2016: Cancer
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