keyword
MENU ▼
Read by QxMD icon Read
search

Prostate cancer mortality epidemiology

keyword
https://www.readbyqxmd.com/read/29339806/tumor-characteristics-treatments-and-oncological-outcomes-of-prostate-cancer-in-men-aged-%C3%A2-50-years-a-population-based-study
#1
Raisa S Pompe, Ariane Smith, Marco Bandini, Michele Marchioni, Tristan Martel, Felix Preisser, Sami-Ramzi Leyh-Bannurah, Jonas Schiffmann, Fred Saad, Hartwig Huland, Markus Graefen, Shahrokh F Shariat, Derya Tilki, Pierre I Karakiewicz
BACKGROUND: To examine clinical characteristics, treatment modalities and oncological outcomes of prostate cancer (PCa) according to young (≤50) vs. old age. METHODS: Of 407,599 men with primary adenocarcinoma of the prostate within the Surveillance, Epidemiology and End Results (SEER)-database (2004 to 2013), 18,387 were aged ≤50 years (4.5%). Time trends, cumulative incidence, and competing risks regression (CRR) analyses tested for differences between young and old patients...
January 16, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29311132/the-epidemiology-of-prostate-cancer
#2
Claire H Pernar, Ericka M Ebot, Kathryn M Wilson, Lorelei A Mucci
Prostate cancer is a major cause of disease and mortality among men, and each year 1.6 million men are diagnosed with and 366,000 men die of prostate cancer. In this review, we discuss the state of evidence for specific genetic, lifestyle, and dietary factors associated with prostate cancer risk. Given the biological heterogeneity of this cancer, we focus on risk factors for advanced or fatal prostate cancer. First, we provide descriptive epidemiology statistics and patterns for prostate cancer incidence and mortality around the world...
January 8, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29311051/relationship-between-state-level-google-online-search-volume-and-cancer-incidence-in-the-united-states-retrospective-study
#3
Charles A Phillips, Allison Barz Leahy, Yimei Li, Marilyn M Schapira, L Charles Bailey, Raina M Merchant
BACKGROUND: In the United States, cancer is common, with high morbidity and mortality; cancer incidence varies between states. Online searches reflect public awareness, which could be driven by the underlying regional cancer epidemiology. OBJECTIVE: The objective of our study was to characterize the relationship between cancer incidence and online Google search volumes in the United States for 6 common cancers. A secondary objective was to evaluate the association of search activity with cancer-related public events and celebrity news coverage...
January 8, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29306731/the-impact-of-lymph-node-metastases-burden-at-radical-prostatectomy
#4
Felix Preisser, Michele Marchioni, Sebastiano Nazzani, Marco Bandini, Zhe Tian, Raisa S Pompe, Francesco Montorsi, Fred Saad, Firas Abdollah, Thomas Steuber, Hans Heinzer, Hartwig Huland, Markus Graefen, Derya Tilki, Pierre I Karakiewicz
BACKGROUND: We hypothesized that a cut-off in positive lymph node (LN) counts may discriminate between cancer-specific mortality (CSM) rates in clinically localized prostate cancer patients treated with radical prostatectomy (RP). OBJECTIVE: To test this relationship, we relied on different LN count cut-offs, as well as the continuously coded number of positive LNs (NPN). METHODS: Within the Surveillance, Epidemiology, and End Results database (2004-2014), we identified patients with D'Amico intermediate- or high-risk characteristics who underwent RP and pelvic LN dissection, regardless of pathologic LN stage...
January 3, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29288121/contemporary-incidence-outcomes-of-prostate-cancer-lymph-node-metastases
#5
Adrien N Bernstein, Jonathan E Shoag, Ron Golan, Joshua A Halpern, Edward M Schaeffer, Wei-Chun Hsu, Paul L Nguyen, Art Sedrakyan, Ronald C Chen, Scott E Eggener, Jim C Hu
PURPOSE: The incidence of localized prostate cancer has declined with shifts in prostate cancer screening. While recent population-based studies demonstrate a stable incidence of loco-regional prostate cancer, this categorized organ-confined, extra-prostatic and lymph node positive disease together. The contemporary incidence of prostate cancer with pelvic lymph node metastases (PLNM) however, remains unknown. METHODS: We used Surveillance, Epidemiology and End Results (SEER) from 2004 to 2014 to identify men diagnosed with prostate cancer...
December 26, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29204518/the-pervasive-crisis-of-diminishing-radiation-therapy-access-for-vulnerable-populations-in-the-united-states-part-1-african-american-patients
#6
Shearwood McClelland, Brandi R Page, Jerry J Jaboin, Christina H Chapman, Curtiland Deville, Charles R Thomas
Introduction: African Americans experience the highest burden of cancer incidence and mortality in the United States and have been persistently less likely to receive interventional care, even when such care has been proven superior to conservative management by randomized controlled trials. The presence of disparities in access to radiation therapy (RT) for African American cancer patients has rarely been examined in an expansive fashion. Methods and materials: An extensive literature search was performed using the PubMed database to examine studies investigating disparities in RT access for African Americans...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29163372/hyperglycemia-promotes-tmprss2-erg-gene-fusion-in-prostate-cancer-cells-via-upregulating-insulin-like-growth-factor-binding-protein-2
#7
Jeff M P Holly, Jessica Broadhurst, Rehanna Mansor, Amit Bahl, Claire M Perks
Background: Epidemiologic evidence shows that obesity is associated with a greater risk of aggressive prostate cancer (PCa) and PCa-specific mortality and this is observed mainly in men with the TMPRSS2-ERG gene fusion. Obesity is often associated with comorbid conditions such as type 2 diabetes and hyperglycemia: we investigated whether some of the exposures associated with disturbed metabolism can also affect the frequency of this gene fusion. Methods: Fusion was induced in LNCaP PCa cells in normal or high levels of glucose, with or without insulin-like growth factor binding protein-2 (IGFBP-2) silenced or the presence of insulin-like growth factor-1 (IGF-I), insulin, or epidermal growth factor (EGF)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29149887/prostate-cancer-in-firefighting-and-police-work-a-systematic-review-and-meta-analysis-of-epidemiologic-studies
#8
REVIEW
Jeavana Sritharan, Manisha Pahwa, Paul A Demers, Shelley A Harris, Donald C Cole, Marie-Elise Parent
OBJECTIVES: We conducted a systematic review and meta-analysis to evaluate potential associations between firefighting and police occupations, and prostate cancer incidence and mortality. METHODS: Original epidemiological studies published from 1980 to 2017 were identified through PubMed and Web of Science. Studies were included if they contained specific job titles for ever/never firefighting and police work and associated prostate cancer risk estimates with 95% confidence intervals (CI)...
November 17, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29129028/improved-cancer-specific-free-survival-and-overall-free-survival-in-contemporary-metastatic-prostate-cancer-patients-a-population-based-study
#9
Marco Bandini, Raisa S Pompe, Michele Marchioni, Emanuele Zaffuto, Giorgio Gandaglia, Nicola Fossati, Luca Cindolo, Francesco Montorsi, Alberto Briganti, Fred Saad, Pierre I Karakiewicz
OBJECTIVES: Over the past decade, several systemic agents as docetaxel, cabazitaxel, sipuleucel-T, abiraterone and enzalutamide have improved overall survival (OS) in metastatic prostate cancer (mPCa) patients. However, to date the OS benefit was not demonstrated in population-based analysis. METHODS: Between 2004 and 2014, 19,047 men with de novo mPCa were identified within the Surveillance Epidemiology and End Results database. Median year of diagnosis resulted in two groups: historical (2004-2008) and contemporary (2009-2014)...
November 11, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29084350/prostate-cancer-outcomes-for-men-aged-younger-than-65-years-with-medicaid-versus-private-insurance
#10
Amandeep R Mahal, Brandon A Mahal, Paul L Nguyen, James B Yu
BACKGROUND: In the current national debate regarding private insurance versus Medicaid expansion, understanding how insurance is associated with racial disparities in prostate cancer (CaP) outcomes has broad policy implications. In the current study, the authors examined the association between insurance status, race, and CaP outcomes. METHODS: The Surveillance, Epidemiology, and End Results program identified 155,524 men aged < 65 years who were diagnosed with CaP from 2007 through 2014...
October 30, 2017: Cancer
https://www.readbyqxmd.com/read/29063853/lack-of-benefit-from-the-addition-of-external-beam-radiation-therapy-to-brachytherapy-for-intermediate-and-high-risk-prostate-cancer
#11
David D Yang, Vinayak Muralidhar, Paul L Nguyen, Ivan Buzurovic, Neil E Martin, Kent W Mouw, Phillip M Devlin, Quoc-Dien Trinh, Peter F Orio, Martin T King
PURPOSE: A recent randomized controlled trial demonstrated that the addition of external beam radiation therapy (EBRT) to brachytherapy did not improve progression-free survival in select patients with intermediate-risk prostate cancer. We evaluated whether the addition of EBRT to brachytherapy improves prostate cancer-specific mortality (PCSM) for intermediate- and high-risk disease using a large national database. METHODS AND MATERIALS: We identified 5836 patients in the Surveillance, Epidemiology, and End Results-Medicare linked database with a diagnosis of National Comprehensive Cancer Network intermediate-risk (Gleason score 7, prostate-specific antigen 10-20 ng/mL, or stage cT2b-T2c) or high-risk (Gleason score 8-10 or prostate-specific antigen >20 ng/mL and stage ≤cT3a) prostate cancer who had undergone brachytherapy, with or without EBRT and androgen deprivation therapy (ADT)...
November 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28971824/cancer-patterns-trends-and-transitions-in-peru-a-regional-perspective
#12
REVIEW
Marion Piñeros, Willy Ramos, Sébastien Antoni, Graciela Abriata, Luis E Medina, J Jaime Miranda, Eduardo Payet, Freddie Bray
Peru, like several other South American countries, is experiencing remarkable population growth, ageing, and urbanisation, which has given rise to profound changes in its epidemiological profile. Prostate and breast cancer are the most frequent cancers in men and women, respectively, in Lima and Arequipa, the two areas with population-based cancer registries. However, infection-associated cancers (cervix and stomach) are also common, and rank highest in the national cancer mortality profile. Although a foundation of surveillance informs cancer-control initiatives in Peru, improvements in the vital statistics system, and the quality and use of incidence data for the planning and assessment of cancer prevention and control actions, are needed...
October 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28946846/descriptive-characteristics-of-prostate-cancer-in-patients-with-a-history-of-primary-male-breast-cancer-a-seer-analysis
#13
Nikita Abhyankar, Kent F Hoskins, Michael R Abern, Gregory S Calip
BACKGROUND: Current evidence on risk of prostate cancer following a diagnosis of male breast cancer is limited and guidance for screening in this potentially higher-risk population remainsunclear. Our objective was to quantify prostate cancer risk in men diagnosed with breast cancer. METHODS: We identified men diagnosed with first primary breast cancer between 1988 and 2012 using the Surveillance, Epidemiology and End Results Program registry databases. Men were followed for occurrence of a second primary prostate cancer and secondary outcomes of cancer-specific and overall survival...
September 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28929037/risk-of-death-from-prostate-cancer-with-and-without-definitive-local-therapy-when-gleason-pattern-5-is-present-a-surveillance-epidemiology-and-end-results-analysis
#14
Jonathan Frandsen, Andrew Orton, Dennis Shrieve, Jonathan Tward
Purpose The purpose is to evaluate the patterns of care and comparative effectiveness for cause-specific and overall survival of definitive local treatments versus conservatively managed men with a primary or secondary Gleason pattern of 5. Methods and materials Patients diagnosed from 2004 to 2012 with a primary or secondary Gleason pattern of 5 N0M0 prostate cancer were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier and Cox regression analyses were used to estimate the survival...
July 10, 2017: Curēus
https://www.readbyqxmd.com/read/28919182/population-based-study-of-the-incidence-and-survival-for-intraductal-carcinoma-of-the-prostate
#15
Brian F Dinerman, Francesca Khani, Ron Golan, Adrien N Bernstein, Michael F Cosiano, Daniel J Margolis, Jim C Hu
PURPOSE: The degree to which intraductal carcinoma of the prostate (IDC-P) affects clinical course remains poorly understood owing to small sample sizes from single-center studies. We sought to determine prognostic factors and outcomes associated with IDC-P in radical prostatectomy (RP) specimens. MATERIALS AND METHODS: This is a retrospective study of RP during 2004 to 2013 using Surveillance, Epidemiology, and End Results to compare IDC-P with non-IDC-P. The effect of IDC-P on overall and disease-specific survival was assessed using Cox regression with a median follow-up of 4...
September 14, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28889025/industrial-pollution-and-cancer-in-spain-an-important-public-health-issue
#16
Pablo Fernández-Navarro, Javier García-Pérez, Rebeca Ramis, Elena Boldo, Gonzalo López-Abente
Cancer can be caused by exposure to air pollution released by industrial facilities. The European Pollutant Release and Transfer Register (E-PRTR) has made it possible to study exposure to industrial pollution. This study seeks to describe the industrial emissions in the vicinity of Spanish towns and their temporal changes, and review our experience studying industrial pollution and cancer. Data on industrial pollutant sources (2007-2010) were obtained from the E-PRTR registries. Population exposure was estimated by the distance from towns to industrial facilities...
November 2017: Environmental Research
https://www.readbyqxmd.com/read/28822996/examining-bias-in-studies-of-statin-treatment-and-survival-in-patients-with-cancer
#17
Louise Emilsson, Xabier García-Albéniz, Roger W Logan, Ellen C Caniglia, Mette Kalager, Miguel A Hernán
Importance: Patients with cancer who use statins appear to have a substantially better survival than nonusers in observational studies. However, this inverse association between statin use and mortality may be due to selection bias and immortal-time bias. Objective: To emulate a randomized trial of statin therapy initiation that is free of selection bias and immortal-time bias. Design, Setting, and Participants: We used observational data on 17 372 patients with cancer from the Surveillance, Epidemiology, and End Results (SEER)-Medicare database (2007-2009) with complete follow-up until 2011...
August 20, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28753893/contemporary-trends-in-the-incidence-of-metastatic-prostate-cancer-among-us-men-results-from-nationwide-analyses
#18
Deepansh Dalela, Maxine Sun, Mireya Diaz, Patrick Karabon, Thomas Seisen, Quoc-Dien Trinh, Mani Menon, Firas Abdollah
Studies have noted contrasting findings with regard to the contemporary incidence of metastatic prostate cancer (PCa) in the USA, especially in light of the United States Preventive Services Task Force (USPSTF) recommendations against prostate-specific antigen (PSA) screening in recent years. We used data from the 18 population- based tumor registries of the Surveillance, Epidemiology and End Results (SEER) 2004-2013 database to study trends in the incidence of metastatic PCa among men stratified by age and race...
May 12, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28753853/survival-outcomes-in-octogenarian-and-nonagenarian-patients-treated-with-first-line-androgen-deprivation-therapy-for-organ-confined-prostate-cancer
#19
Paolo Dell'Oglio, Mohamed Bishr, Katharina Boehm, Vincent Trudeau, Alessandro Larcher, Zhe Tian, Josè Sosa, Marco Moschini, Fred Saad, Umberto Capitanio, Alberto Briganti, Markus Graefen, Francesco Montorsi, Pierre I Karakiewicz
BACKGROUND: The use of primary androgen deprivation therapy (PADT) is common in elderly men with early-stage prostate cancer (PCa), despite the absence of guideline recommendations. OBJECTIVE: To examine survival patterns of octo- and nonagenarian men with organ-confined PCa exposed to PADT, to assess whether their life expectancy warrants androgen deprivation therapy use. DESIGN, SETTING, AND PARTICIPANTS: In the Surveillance, Epidemiology, and End Results-Medicare-linked database, we identified 14 785 octo- and nonagenarian organ-confined PCa patients treated with PADT between 1991 and 2009...
February 11, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28721887/external-beam-radiation-therapy-with-a-brachytherapy-boost-versus-radical-prostatectomy-in-gleason-pattern-5-prostate-cancer-a-population-based-cohort-study
#20
COMPARATIVE STUDY
Chenyang Wang, Amar U Kishan, Mitchell Kamrava, Michael L Steinberg, Christopher R King
PURPOSE: Patients with prostate cancer (PCa) containing Gleason pattern (GP) 5 disease experience a greater and earlier incidence of prostate cancer-specific mortality (PCSM) than general PCa patients. This affords the statistical power to compare PCSM outcomes among different treatment modalities even when restricting the analysis to patients treated in the modern era. The purpose of the present study was to compare the survival outcomes among patients with GP 5 PCa on needle core biopsy or transurethral resection of the prostate who underwent extremely dose-escalated radiation therapy (RT; exemplified by external beam RT with a brachytherapy boost [EBRT + BT]) versus radical prostatectomy (RP) in the modern era...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
keyword
keyword
74132
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"